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Chakraborty, Soham, Akhil Boddul, Vivek Patil, Ganesh Raje und Prof Ujwala Gaikwad. „E-KYC System Using Blockchain“. International Journal for Research in Applied Science and Engineering Technology 11, Nr. 7 (31.07.2023): 1174–81. http://dx.doi.org/10.22214/ijraset.2023.54834.
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Abstract: Know your client or simply KYC, is a process utilized by businesses and financial institutions to identify their clients and evaluate any potential risks associated with illegal intentions and unethical behavior. The term KYC often refers to bank regulations and anti-money laundering regulations aimed at governing these activities. Due to concerns over bribery and unethical behavior, companies of all sizes are required to implement KYC to ensure their agents, consultants, and distributors comply with anti-bribery regulations. Despite the use of traditional KYC systems, there are limitations to their effectiveness. To address these limitations, a proposed system has been developed that uses the immutable nature of Distributed Ledger Technology (DLT) to create a tamper-proof system. This system enables customers and financial institutions to verify and record KYC documents on the DLT, providing greater efficiency, cost reduction, improved customer experience, and end-to-end transparency in integrating customer documents into the bank's database. Additionally, this system eliminates the need for repeated KYC checks performed by banks through the creation of a secure and common blockchain database. The blockchain's secure nature ensures that unauthorized changes to the data are immediately invalidated and the use of a proof-of-reputation concept makes the verification process more robust.
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Auti, Mr Suryakant. „Trustworthy E-KYC Systems Using Blockchain“. INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT 08, Nr. 04 (30.04.2024): 1–5. http://dx.doi.org/10.55041/ijsrem31582.
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In today’s world, Leveraging technological advancements, such as digital identity verification and biometric authentication, has streamlined and modernized KYC processes. These innovations not only enhance efficiency but also contribute to a more user-friendly experience for customers. In this contemporary landscape, staying informed about evolving regulations and industry-specific practices is indispensable for effective KYC implementation. Financial institutions must continuously adapt to the changing regulatory environment and leverage technological solutions to maintain the integrity of their KYC processes. This proactive approach is crucial not only for compliance but also for building trust between customers and stakeholders in an era where financial security and transparency are paramount. KYC procedures have been simplified and brought up to date by utilizing technology innovations like biometric authentication and digital identity verification. These advancements contribute to a more user-friendly experience for customers in addition to increasing efficiency. Keeping up with changing laws and sector-specific procedures is essential for implementing KYC successfully in the modern world. It is imperative for financial institutions to consistently adjust to the dynamic regulatory landscape and utilize technological advancements to uphold the integrity of their KYC procedures. This proactive strategy is essential for both compliance and fostering stakeholder and customer trust in a time when financial stability and openness are critical. Index Terms – KYC - know your customer, AML - anti-money laundering, CTF - counter-terrorism financing Keywords – KYC, blockchain, etherium, encryption, compression
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Elinzano, Gerand Boy O., und Michelle Renee D. Ching. „Factors that leads to Adoption and Use of Online Bank Account Opening through e-KYC using UTAUT and its Extensions“. RSF Conference Series: Engineering and Technology 2, Nr. 1 (22.04.2022): 85–94. http://dx.doi.org/10.31098/cset.v2i1.508.
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Financial Inclusion has been determined as one of the factors affecting national development. Bank account opening provides opportunity to more banking services and as such central banks have been supporting the use of Electronic-Know-Your-Customer (e-KYC) even before COVID-19 pandemic. While the benefits of e-KYC for the banks and its customers are clear, the widespread use of such process for account opening is still in its early adoption stage. This research employed a quantitative method by adopting the Unified Theory of Acceptance and Use of Technology as as theoretical foundation and extension constructs and determined the factors affecting the use and adoption of e-KYC for online bank account opening. As a result, facilitating conditions and perceived security were found to be significant factors affecting the intension to use e-KYC. Through this research, it was able to validate the use of the research model in studying e-KYC adoption and provided management key areas leading to e-KYC use that they may focus on.
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Shinde, Tejas, Devanshi Wadkar, Tanuj Gupta, Samarjeet Kunjeer und Anuradha Deokar. „Decentralized E-KYC Blockchain Network for Central Bank“. International Journal for Research in Applied Science and Engineering Technology 11, Nr. 3 (31.03.2023): 2003–13. http://dx.doi.org/10.22214/ijraset.2023.49860.
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Abstract: Know Your Customer or KYC processes are the backbones of a financial institution’s anti-money laundering efforts. KYC processes are mandatory in most of Europe and India. Almost all countries have their own process for identifying and keeping a record of their citizens like the USA has Social Security Protocol. According to current estimates, the amount of KYC spending rose to up to $1.8 Billion in 2021 on a global level. Despite the importance of the process, KYC continues to operate inefficiently. KYC processes are labor-intensive and time-consuming tasks. It is estimated that 80% of KYC efforts go in gathering information and processing while only 20% of efforts are evaluating and monitoring focused. This centralization of data is causing an inefficient KYC process and creating issues like :- Misidentification of fraudulent data , Inability of tracking customers, customers entering fake data(address, age etc) , delayed processing time and very high cost of processing. Reimagining KYC Using Blockchain Technology will enable seamless and secure data exchange at a fraction of the cost. A decentralized blockchain network will Facilitate near real-time data exchange. Blockchain when used with other technologies can indicate great potential to help organizations reduce the cost and time linked with the KYC process. The introduction of blockchain in KYC brings data on a decentralized network which also has its own pros like distributed data collection ,higher operational efficiency , validation of accuracy of the information. The customer will build their profile on the DCT KYC network. There are multiple options to store the data like Centralized encrypted servers, DCT platforms like IPFS(Interplanetary File System). Customers will perform transactions with Financial Institutions by giving them access to users profile( restricted non-appendable access),Using hashing and cryptographic processes the data would safely be called and returned to the DCT network . Thus making sure the whole process is immutable .
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Putra, Diego Belva, M. Abd Malik Hakim und Bambang Nurdewanto. „Implementasi Electronic-Know Your Customer pada aplikasi Fintech untuk meningkatkan keamanan akun user“. Journal of Information System and Application Development 1, Nr. 2 (30.09.2023): 111–20. http://dx.doi.org/10.26905/jisad.v1i2.11112.
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The information technology development can make financial transactions easier, but the security of Fintech applications such as Bangbeli is a critical issue that can be addressed through the implementation of the Electronic-Know Your Customer (E-KYC) feature to increase user trust. The aim of this research is to apply E-KYC technology as an additional feature in the Bangbeli application at PT. Doa Anak Digital. The approach used is the agile development method which consists of six stages, including requirements, design, development, testing, implementation and review. This research uses a qualitative approach, involving interviews with selected sources to ensure that the E-KYC feature can improve user account security. Implementation includes coding and implementing E-KYC in the Bangbeli application, followed by testing using the black box method to identify errors or bugs in the E-KYC system. The results of the research show conformity with the initial design, with features that run according to their function. As a result of interviews with users and Bangbeli regarding the implementation of the E-KYC feature, a number of feedback were obtained including an easy to understand flow, innovations that increase security, confidence in sending personal data, and the impression that this platform cares about user security.
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Gadhave, Miss Arati, und Prof Megha M. Bhogawar. „Review Paper- Study on Central Know Your Customer (CKYC)“. INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT 08, Nr. 01 (08.01.2024): 1–13. http://dx.doi.org/10.55041/ijsrem27980.
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To Know Your Customer (CKYC) Policy is introduced in financial industry to prevent the Bank from being used by criminal elements for money laundering activities and to understand the customer and their financial dealings to manage their risks prudently. Know your customer policies are very important for identity theft fraud, Anti money laundering and terrorist financing. In order to reduce the risk of identity fraud document forgery and have paperless KYC verification UIDAI has launched its E-KYC service. In order to help investors and customers CKYC is introduced by Government of India in Feb 2017. Government of India has authorized a central Registry of Securitization of Asset Reconstruction and Security Interest of India (CERSAI) to act as, and perform the function of CKYC. KEYWORDS – Unified Customer Number, Block chain in KYC, Increase Global KYC Standard, Maintain Secrecy, Know your customer.
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HARIS RISKI RAKHMAN und FAYRUZ RAHMA. „PENGEMBANGAN UI/UX MOBILE PADA PEMBUKAAN REKENING DIGITAL SAVING SECARA E-KYC DENGAN PENDEKATAN DESIGN THINKING“. Jurnal INSTEK (Informatika Sains dan Teknologi) 7, Nr. 2 (03.08.2022): 164–73. http://dx.doi.org/10.24252/instek.v7i2.30961.
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Pandemi COVID-19 menjadi salah satu tantangan bagi perusahaan perbankan untuk dapat berevolusi demi mencapai target. Pembuatan tabungan secara online bagi para partisipan dimulai selama masa pandemi COVID-19. Hal ini dilakukan untuk menghindari kerumunan orang dan menghindari proses pengantrian yang pada umumnya terjadi apabila menggunakan metode offline. Aplikasi Digital Saving adalah aplikasi yang menyediakan wadah kepada nasabah untuk melakukan pembukaan rekening secara online tanpa harus datang ke bank dan unduh aplikasi. Sistem yang digunakan pada aplikasi ini adalah e-KYC. e-KYC (electronic Know Your Customer) merupakan pengenalan pelanggan secara elektronik atau digital yang melibatkan sistem. Sehingga proses tersebut dapat dilakukan dengan mudah tanpa melibatkan kontak fisik. Proses pengembangan penelitian ini menggunakan pendekatan design thinking yang memiliki beberapa tahap yaitu: emphatize, define, ideate, prototype, dan testing. Dalam penelitian ini, penulis mengharapkan di masa pandemi COVID-19 dapat membantu masyarakat agar lebih mudah untuk membuka rekening secara online.
Kata kunci: Design Thinking, Digital Saving, e-KYC, User Experience, User Interface.
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Khafialima Zahra, Rally Nufi, und Kukuh Tejomurti. „PENERAPAN PRINSIP KYC PADA FINANCIAL TECHNOLOGY P2P LENDING YANG AKOMODATIF BAGI PERLINDUNGAN KONSUMEN“. Jurnal Privat Law 11, Nr. 2 (24.11.2023): 238. http://dx.doi.org/10.20961/privat.v11i2.49016.
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<p align="center"><em>Abstract</em></p><p><em>This article aims to know the legal problem and solution for FinTech P2P Lending Company that is not doing verification or rechecking their Borrowers. This type of article is normative legal research that is prescriptive to find a new concept for resolving the legal problem by using the statute approach. This article uses secondary data with primary legal material and library research. The data analysis technique used by the author is a deduction and syllogism analysis. The result of this research is a Borrower who committing fraud by using other person’s identity or fake account can be found because of personal data leaks dan sells personal data by social media. Moreover, fake account on P2P Lending also caused by FinTech P2P Lending Company who is not using KYC Principles as appropriate in the bank or not rechecking their Borrowers. A solution for FinTech P2P Lending Company who wants to apply KYC Principles in their P2P Lending platform is using e-KYC.</em></p><p><em>Keywords: Fake accounts; e-KYC; P2P Lending</em></p><p align="center">Abstrak</p><p>Artikel ini bertujuan untuk mengetahui akibat hukum serta solusi bagi Penyelenggara <em>FinTech P2P Lending</em> yang tidak melakukan verifikasi atau pemeriksaan ulang terhadap Penerima Pinjamannya. Artikel ini termasuk ke dalam jenis penelitian normatif yang bersifat preskriptif untuk menemukan konsep baru guna menjawab isu hukum yang dihadapi dengan menggunakan pendekatan perundang-undangan. Data yang digunakan dalam artikel ini merupakan data sekunder dengan bahan hukum primer yang menggunakan teknik pengumpulan data hukum kepustakaan. Teknik analisis data yang digunakan oleh penulis adalah teknik analisis data yang bersifat deduksi dengan metode silogisme. Hasil penelitian menunjukkan bahwa terdapat Penerima Pinajaman yang melakukan penipuan identitas atau munculnya akun palsu yang disebabkan adanya kebocoran data pribadi dan praktik jual-beli data pribadi pada media sosial. Selain itu, munculnya akun palsu pada <em>P2P Lending</em> juga disebabkan karena Penyelenggara <em>FinTech P2P Lending</em> tidak menerapkan prinsip KYC layaknya perbankan atau melakukan pemeriksaan ulang terhadap Penerima Pinjamannya. Solusi bagi Penyelenggara <em>FinTech P2P Lending</em> yang ingin menerapkan prinsip KYC pada <em>platform P2P Lending</em> miliknya adalah dengan menggunakan <em>e-KYC</em>.</p><p>Kata Kunci: Akun palsu; <em>e-KYC</em>; <em>P2P Lending</em></p>
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Tahe, Mr Fitree, und Maria Ulfah Siregar. „Perbandingan Faktor-Faktor Yang Mempengaruhi Penggunaan Electronic-Know Your Customer (e-Kyc)“. JISKA (Jurnal Informatika Sunan Kalijaga) 6, Nr. 3 (22.09.2021): 189–200. http://dx.doi.org/10.14421/jiska.2021.6.3.189-200.
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There are many technological developments in banks, one of which is online transactions. To get these transactions, an account should be opened using the electronic know you customer (e-KYC) verification system at banks. This research wants to know the differences in the factors that influence behavioral intentions to use e-KYC to open a bank account for SCB (The Siam Commercial Bank) Thailand and Bank Mandiri Indonesia. This is quantitative research using a survey. We have prepared a questionnaire of 160 respondents: 80 for Bank Mandiri and 80 for SCB. The results indicate that the willingness to use electronic identity verification services influence by the availability of technology, the external impact of the network, safety awareness, perception of trust, and perception of security. The perception of security affects the perception of trust, and technical protection, also the transaction procedure does not affect the perception of trust.
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Utami, Alivia Meyrizka, und Mega Dwi Septivani. „Regulatory Technology (RegTech): The Solution to Prevent Money Laundering in Indonesia“. Telaah Bisnis 23, Nr. 1 (24.07.2022): 86. http://dx.doi.org/10.35917/tb.v23i1.288.
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Since the 2008 financial crisis, the complexity of regulations and the use of technology and innovation in the financial sector have increased. This makes banks as financial institutions starting to adapt to financial technology very vulnerable to technological risks, one of which is money laundering. Regulatory Technology (RegTech) is a technology trend to assist bank management in supporting regulatory compliance efforts and offering money laundering prevention solutions. Based on this, this study aims to examine the relationship of RegTech, which is represented by three independent variables: Electronic Know Your Customer (e-KYC), Transaction Monitoring, and Time and Cost Efficiency, on Money Laundering Prevention. This study shows that transaction monitoring, as well as cost and time efficiency, have a significant effect on money laundering prevention. In contrast, e-KYC does not affect money laundering prevention. This research is intended to provide valuable insights to Financial Institutions to increase awareness of the importance of adopting new technologies and maintaining good relations with regulators to prevent money laundering in Indonesia.
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Ghozi, Ahmad. „THE URGENCY OF ELECTRONIC KNOW YOUR CUSTOMER (E-KYC): HOW ELECTRONIC CUSTOMER IDENTIFICATION WORKS TO PREVENT MONEY LAUNDERING IN THE FINTECH INDUSTRY“. Diponegoro Law Review 7, Nr. 1 (28.04.2022): 34–52. http://dx.doi.org/10.14710/dilrev.7.1.2022.34-52.
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The development of the Financial Technology (FinTech) Industry in Indonesia is very rapid. Financial Technology (FinTech) can generally be defined as an industry that combines technology and financial features as its business model. One of the advantages FinTech business is the speed and convenience for parties to conduct transactions. The speed and simplicity of transactions in the FinTech business are due to the use of technology in the financial services provided. Furthermore, the FinTech industry facilitates parties to conduct non-face-to-face transactions. The advantages offered by the FinTech industry raise concerns that this business could be used by criminals to commit money laundering crimes. This research tries to see the vital role of using Know Your Customer (KYC) customer principles which are carried out electronically to be applicable in preventing FinTech businesses from being used as a means of committing money laundering crimes.
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Kasim, Raja Suzana Raja, Nurul Afiqah Zulazli und Wan Fariza Azima Che Azman. „Do Islamic Fintech Leadership and Technology Adoption Predict Sustainable Entrepreneurship Values among Fintech Organizations?“ International Journal of Religion 5, Nr. 3 (22.03.2024): 466–75. http://dx.doi.org/10.61707/9e0gfj82.
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The primary objectives of this paper are to examine if Islamic Fintech leadership (IFL) and technology adoption (TA) can predict Sustainable Entrepreneurship Values (SEV) among Malaysian Fintech organizations. A survey was self-administered to 294 organisations involved in payment, e-wallet, prop-tech, digital bank, blockchain, cryptocurrency, remittance, AI/data, marketplace, crowdfunding, insurtech, wealthtech, Know Your Customer (KYC), and reg-tech services offerings. Partial Least Square Structural Equation Modelling is used to analyze 121 responses. The results show that IFL has a positive and significant relationship with SEV. TA, however, does not moderate the relationship between IFL and SEV. This paper contributed to developing the extended Technology Acceptance Model and Resource-Based Theory. The SEV model explains the leadership concern for socio-economy, environment, and values by creating a game changer for Islamic digital transformation that enables micro and small enterprises to access faster socio-economic well-being and financial health.
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PICINI, ANGÉLICA GIAROLLA, MARCELO BENTO PAES DE CAMARGO, ALTINO ALDO ORTOLANI, LUIZ CARLOS FAZUOLI und PAULO BOLLER GALLO. „Desenvolvimento e teste de modelos agrometeorológicos para a estimativa de produtividade do cafeeiro“. Bragantia 58, Nr. 1 (1999): 157–70. http://dx.doi.org/10.1590/s0006-87051999000100015.
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Modelos matemáticos agrometeorológicos que relacionam a fenologia, a bienalidade e a produtividade do cafeeiro, foram desenvolvidos e testados para Mococa (SP), a partir de série de dados de produtividade de cafeeiros adultos, variedade Mundo Novo, correspondente ao período de 1966/67 a 1973/74. Os modelos baseiam-se na penalização da produtividade potencial, em função da produtividade do ano anterior e das relações ER/EP (evapotranspiração real e potencial), derivados de balanços hídricos decendiais seqüenciais durante os estádios fenológicos, considerando 16 combinações diferentes. A penalização é feita à medida que haja restrição hídrica para a planta durante os diferentes estádios fenológicos, considerando coeficientes de resposta da cultura ao suprimento hídrico, incorporados numa função aditiva ou multiplicativa. O modelo com penalização aditiva apresentou melhor desempenho na parametrização dos coeficientes em relação ao multiplicativo. Os melhores ajustes entre dados observados e estimados foram obtidos com modelo aditivo que relaciona o fator hídrico durante os trimestres (combinação D1) jun./jul./ag.; set./out./nov. e dez./jan./fev., os quais apresentaram coeficientes de resposta da cultura ao suprimento hídrico (ky) de +0,38 (ky1), +0,61 (ky2) e +0,18 (ky3), respectivamente, para os estádios fenológicos da dormência das gemas/início do florescimento, florescimento/formação do grão e formação do grão/maturação. As magnitudes dos valores de ky1 e ky2 revelam que a produtividade do cafeeiro é particularmente sensível ao estresse hídrico durante os estádios fenológicos do florescimento e formação do grão. O teste do modelo apresentou boas estimativas, com coeficientes de determinação de 0,93 e índice de concordância (d) de 0,98.
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Agusinta, Lira, und Peppy Fachrial. „Human Resource Management Competencies in Banking Organizations in Indonesia“. Syntax Literate ; Jurnal Ilmiah Indonesia 7, Nr. 2 (21.02.2022): 830. http://dx.doi.org/10.36418/syntax-literate.v7i1.6099.
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Background and purpose: In its development, fintech has entered the 4.0 era where it has developed by facilitating the financial system and it is feared that it could become a threat to the world of conventional banking. Therefore, this study aims to develop competency strategies needed by banks in facing the disruption of the fintech 4.0 era. Design/Methodology/Approach: In this study the research approach used is a quantitative approach (post positivist). Data collection is carried out using research instruments, statistical or quantitative analysis, with the aim of testing predetermined hypotheses. Results: The results show that competency-based practice contributes positively to the bottom line, and that contributions to organizations are related to the roles of individuals not to their jobs. Additionally, efforts designed for employee commitment have the potential to generate positive returns, and that training and development are seen as drivers of future success. Conclusion: Even though banking has similar products with fintech companies, it has a different character where banks have a higher prudential principle. Competency is needed for bank employees in dealing with fintech 4.0, namely E-KYC, Payment Gateway, Big Data, Cloud Infrastructure, Artificial Intelligence and digital signatures besides that it also requires the ability to innovate, a willingness to learn and change, and be able to provide creative encouragement where they work
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Putra, Rio Vernika. „UPAYA PENCEGAHAN FRAUD PADA BANK BERPLAT MERAH YANG MERUGIKAN KEUANGAN NEGARA“. Jurnal Magister Hukum Perspektif 12, Nr. 1 (01.05.2022): 13–24. http://dx.doi.org/10.37303/magister.v12i1.54.
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Fraud can occur anywhere and anytime including in red-plated banks (State-Owned Banks). As a place of money turnover, banking cannot be separated from criminal acts both general, civil, and corruption crimes because the Bank has a position that is vulnerable to abuse of authority either by employees on the front line such as tellers, costumer services, loan services or by branch heads even on the Board of Directors. The formulation of the issue raised is how the form of fraud prevention efforts, especially in State-Owned Banks related to the rescue of assets and wealth, is indicated to be detrimental to the country's finances. The type of research used is juridical-normative which is one of the legal research methods obtained by analyzing a legal problem through laws and regulations and related literature. The results found prevention efforts consist of technical and moral aspects and integrity. Technical aspects can be through (1) Double-check customer data, (2) Rewarding Loophole Inventors, (3) Creating good internal controls, (4) Transparency to Customers, (5) Increasing Personnel Supervision, (6) Implementing e-KYC, (7) Whistleblowers. Moral and integrity aspects must be owned by every party involved in activities in the bank. In addition, Law Enforcement Officials (APH) must also comply with the implementation of the commercial bank anti-fraud strategy that has been regulated in the POJK for the Rescue of State Finances and State Assets and National Economic Recovery.
Keywords: Prevention, fraud, bank.
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Karthikeyan, K., und M. Dinesh Kumar. „A Comparative Analysis Study on Mobile Banking and Mobile Wallet Services in India“. ComFin Research 9, Nr. 4 (01.10.2021): 17–23. http://dx.doi.org/10.34293/commerce.v9i4.4307.
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Banking sectors are fully focused on Mobile Banking and Mobile wallets and engage in electronic device and apps initiatives by reducing physical activities in banking operations. Mobile Banking and Mobile Wallet practices perceived various electronic products and services to measures supporting private companies, public and private banking sector procedures to electronic management systems and reduction of fuel and cost proper utilization. They are the best performance and efficiency of Mobile Banking and Mobile Wallet in the key of elements in the financial system. The most important mobile banking services have been mentioned through Account Access, Balance Enquiry, E-Passbook, Account Statement, Fund Transfer, Bill Payment, Branch Locator, ATM Locator and Requests, etc. Mobile wallet’s procedure is to open a zero account to submit KYC for address proof rather than submit a mobile number—payment using a one-time password, pin code, or bar code. The funds are limited to transactions only. Most private companies, public and private sector banks are; Airtel Money, Axis Bank Lime, Citrus Pay, Freecharge, ICICI Pockets, Itz Cash, Jio Money, Mobikwik, Oxigen, mRuppee, Paytm, SBI Buddy, SpeedPay, Vodafone M-Pesa, etc. The awareness of mobile banking and mobile wallet products and services is ready for all people using modern banking activities. Mobile banking and mobile wallets reduce physical activities and use information technology devices for proper handling of banking websites and private company mobile apps etc. This relative study of Mobile Banking and Mobile Wallet shows that there are significant differences in the transactions of Mobile Banking and Mobile Wallet volume and value. Analysis simple percentages have been used to analyze and interpret the data on Mobile Banking and Mobile Wallet volume and value made in India during the study period of 2012-13 to 2018-19 (7 years).
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Omoola, Sodiq, und Hafsat Kamal Ibrahim. „The Legal Implications of Abandoned Digital Assets in Sharīʿah-Compliant Fintech Platforms“. ISRA International Journal of Islamic Finance 15, Nr. 2 (23.05.2023): 60–76. http://dx.doi.org/10.55188/ijif.v15i2.542.
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Purpose — The recent surge in Sharīʿah-compliant fintech platforms has created an increasing volume of intangible digital assets of increasing value across emerging technological platforms. This phenomenon has generated a significant number of digital assets left behind after the demise of their owners. This paper provides a legal analysis of the implications of abandoned digital assets in Sharīʿah-compliant fintech platforms. It seeks answers to two central research questions: what are the Sharīʿah and legal implications of digital assets after the passing of the owner? How can the existing Sharīʿah-compliant fintech platforms prevent uncertainty over digital assets? Design/Methodology/Approach — This is a conceptual paper which adopts a qualitative analysis of both primary and secondary sources from existing journals and regulatory instruments in Islamic finance jurisdictions to explore the gaps in the law regarding digital assets and regulations regarding unclaimed money. The paper further compares the approaches adopted in Malaysia and Saudi Arabia in regulating digital assets and unclaimed moneys. Findings — The paper finds that there is scope for the administration of digital assets in both regulated and unregulated Sharīʿah-compliant fintech platforms. Similarly, the adoption of e-KYC that complies with the Sharīʿah ethos is essential to ensure that digital assets are not lost upon the account holder’s demise. The legal right and title of the account holder and legal heirs can only be protected through the operation of digital assets regulation in a Sharīʿah-compliant fintech environment. Originality — This paper is of value to administrators and legal heirs of account holders in fintech environments. It recommends measures to prevent intestacy and uphold the account holders’ and legal heirs’ intergenerational property rights and financial benefits. Research Limitations/Implications — As a conceptual paper, the attitude of digital asset users is not examined due to the absence of quantitative or qualitative data on devolution of digital assets. Practical Implications — Although this study focuses on the implication of digital assets for Sharīʿah-compliant fintech platforms, the findings may well have a bearing on policymakers, legal practitioners, and administrators of estates in the management of emerging asset classes. Article Classification — Conceptual paper
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Nasompag, Sawinee, Pawinee Siritongsuk, Saengrawee Thammawithan, Oranee Srichaiyapol, Panchika Prangkio, Terri A. Camesano, Chomdao Sinthuvanich und Rina Patramanon. „AFM Study of Nanoscale Membrane Perturbation Induced by Antimicrobial Lipopeptide C14 KYR“. Membranes 11, Nr. 7 (30.06.2021): 495. http://dx.doi.org/10.3390/membranes11070495.
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Lipopeptides have been extensively studied as potential antimicrobial agents. In this study, we focused on the C14-KYR lipopeptide, a modified version of the KYR tripeptide with myristic acid at the N-terminus. Here, membrane perturbation of live E. coli treated with the parent KYR and C14-KYR peptides was compared at the nanoscale level using AFM imaging. AFM analyses, including average cellular roughness and force spectroscopy, revealed the severe surface disruption mechanism of C14-KYR. A loss of surface roughness and changes in topographic features included membrane shrinkage, periplasmic membrane separation from the cell wall, and cytosolic leakage. Additional evidence from synchrotron radiation FTIR microspectroscopy (SR-FTIR) revealed a marked structural change in the membrane component after lipopeptide attack. The average roughness of the E. coli cell before and after treatment with C14-KYR was 129.2 ± 51.4 and 223.5 ± 14.1 nm, respectively. The average rupture force of the cell treated with C14-KYR was 0.16 nN, four times higher than that of the untreated cell. Our study demonstrates that the mechanistic effect of the lipopeptide against bacterial cells can be quantified through surface imaging and adhesion force using AFM.
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Krippes, Karl A. „Review of Kang (1988): Hankwuk-e Kye Thong Non“. Diachronica 6, Nr. 1 (01.01.1989): 141–50. http://dx.doi.org/10.1075/dia.6.1.11kri.
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Marongiu, Cinzia. „Cartografie di appartenenza: Igiaba Scego e Kym Ragusa l'affermazione di identità plurali“. Italica 99, Nr. 1 (01.03.2022): 106–18. http://dx.doi.org/10.5406/23256672.99.1.08.
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Abstract La traiettoria biografica di Kym Ragusa e Igiaba Scego e delle loro rispettive famiglie non è la stessa: mentre i nonni dell'autrice italo-afroamericana Kym Ragusa si sono spostati dall'Italia in America, i genitori di Igiaba Scego sono scappati dalla Somalia per raggiungere l'Italia. Ciò nonostante, le due autrici e le loro narrazioni hanno diversi punti in comune: entrambe sono di origine africana, entrambe parlano di una generazione di confine ed entrambe mostrano fiere un'identità multipla che mette in crisi le linee di demarcazione tracciate dal discorso dominante che vuole l'appartenenza identitaria come qualcosa di circoscritto e fisso. Ragusa e Scego mettono in discussione il vecchio dibattito sull'appartenenza nei loro racconti polietnici, evidenziando come non esista un unico paradigma attraverso cui definire la loro identità, perché le loro molteplici appartenenze identitarie non si possono descrivere con un carattere e/o fissare in una posizione stabile. Scego e Ragusa sono autrici dall'identità liquida che non tollerano distinzioni e separazioni. Questo è evidente in modo particolare nel romanzo di Igiaba Scego La mia casa è dove sono e nel memoir di Kym RagusaLa pelle che ci separa, dove le protagoniste sono delle creature doppie, delle “equilibriste in bilico” (termine usato da entrambe le autrici) fra due mondi (Scego 2010: 55). L'obiettivo di Kym Ragusa e Igiaba Scego in queste due opere è quello di resuscitare il “cadavere” di un passato dimenticato per “rimettere la carne sulle ossa” (Ragusa 95), ossia riempire i buchi della loro storia riscoprendo la ricchezza nella diversità delle loro origini. Le protagoniste di La mia casa è dove sono e di La pelle che ci separa tracciano una sorta di mappa, attraverso le storie dei loro antenati, che riflette il percorso geografico degli spostamenti della loro famiglia: percorso che permette loro di ricostruire la propria identità arricchendola di punti di vista, memorie e immagini. In questo articolo mi concentrerò principalmente sui temi e le trame di questi due libri, analizzandone le similarità e le differenze. Mostrerò come le protagoniste riescano a fondere la loro cultura d'origine e la cultura d'arrivo facendo delle loro eredità etniche un ponte (Igiaba Scego) / un crocevia (Kym Ragusa) che unisce e non separa. Durante la mia analisi, mi soffermerò in particolar modo sulla memoria coloniale e quella di immigrazione, sui sentimenti di appartenenza, sulla nozione di doppia coscienza (quella italiana e quella africana), il concetto di identità interstiziale (a metà tra la cultura di partenza e quella di arrivo, mitad y mitad per usare le parole della Anzaldúa) e di luoghi interstiziali (in between dirla come Homi Bhabba) dove l'ibridazione diviene possibile e immaginabile, come la Sicilia per Kym Ragusa e Roma per Igiaba Scego. Concluderò dimostrando come, in entrambi i memoir, l'ibridità, che appare inizialmente come una spaccatura tra due sfere culturali incompatibili, si sana attraverso la ricomposizione i ricordi e la conciliazione delle diverse componenti identitarie delle due protagoniste.
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Ogihara, Cristiana A., Gerhardus H. M. Schoorlemmer, Maria de Fátima M. Lazari, Gisele Giannocco, Oswaldo U. Lopes, Eduardo Colombari und Monica A. Sato. „Swimming Exercise Changes Hemodynamic Responses Evoked by Blockade of Excitatory Amino Receptors in the Rostral Ventrolateral Medulla in Spontaneously Hypertensive Rats“. BioMed Research International 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/487129.
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Exercise training reduces sympathetic activity in hypertensive humans and rats. We hypothesized that the swimming exercise would change the neurotransmission in the rostral ventrolateral medulla (RVLM), a key region involved in sympathetic outflow, and hemodynamic control in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats. Bilateral injections of kynurenic acid (KYN) were carried out in the RVLM in sedentary- (S-) or exercised- (E-) SHR and WKY rats submitted to swimming for 6 weeks. Rats wereα-chloralose anesthetized and artificially ventilated, with Doppler flow probes around the lower abdominal aorta and superior mesenteric artery. Injections into the RVLM were made before and after i.v. L-NAME (nitric oxide synthase, NOS, inhibitor). Injections of KYN into the RVLM elicited a major vasodilation in the hindlimb more than in the mesenteric artery in E-SHR compared to S-SHR, but similar decrease in arterial pressure was observed in both groups. Injections of KYN into the RVLM after i.v. L-NAME attenuated the hindlimb vasodilation evoked by KYN and increased the mesenteric vasodilation in E-SHR. Swimming exercise can enhance the hindlimb vasodilation mediated by peripheral NO release, reducing the activation of neurons with EAA receptors in the RVLM in SHR.
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ERNE, LUKAS. „W. E. BURTON'S DRAMATIC WORKS OF THOMAS KYD OF 1848“. Notes and Queries 44, Nr. 4 (1997): 485–87. http://dx.doi.org/10.1093/nq/44.4.485.
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Erne, L. „W. E. Burton's Dramatic Works of Thomas Kyd of 1848“. Notes and Queries 44, Nr. 4 (01.12.1997): 485–87. http://dx.doi.org/10.1093/notesj/44.4.485.
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GRIMANI, CATIA. „HINTS ON PULSAR ELECTROMAGNETIC ENERGY LOSSES FROM COSMIC-RAY POSITRON OBSERVATIONS“. International Journal of Modern Physics A 20, Nr. 29 (20.11.2005): 6735–38. http://dx.doi.org/10.1142/s0217751x05029964.
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We present preliminary results of the estimate of isolated pulsar contribution to the positron and electron interstellar fluxes when a polar cap model is assumed. Pulsars of all ages outside their host remnants have been considered. Cosmic-ray positron observations above a few GeV seem to indicate that an outer gap model is favoured over a polar cap model when the contribution of young pulsars only is taken into account. Here we show that pulsars with ages ranging between 10 kyr and 600 kyr, escaped from their remnants, give a contribution to the interstellar positron flux larger than that proposed in literature for the whole sample of pulsars younger than 10 kyr. Consequently, this result also indicates that outer gap electromagnetic energy losses overcome those at the polar cap. Future, low error e+/(e+ + e-) ratio observations as well as high energy pulsed gamma-ray measurements will allow us to verify this possibility.
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Tarasov, P. E., E. V. Bezrukova und S. K. Krivonogov. „Late Glacial and Holocene changes in vegetation cover and climate in southern Siberia derived from a 15 kyr long pollen record from Lake Kotokel“. Climate of the Past 5, Nr. 3 (01.07.2009): 285–95. http://dx.doi.org/10.5194/cp-5-285-2009.
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Abstract. In this study a radiocarbon-dated pollen record from Lake Kotokel (52°47´ N, 108°07´ E, 458 m a.s.l.) located in southern Siberia east of Lake Baikal was used to derive quantitative characteristics of regional vegetation and climate from about 15 kyr BP (1 kyr=1000 cal. yr) until today. Quantitative reconstruction of the late glacial vegetation and climate dynamics suggests that open steppe and tundra communities predominated in the study area prior to ca. 13.5 kyr BP and again during the Younger Dryas interval, between 12.8 and 11.6 kyr BP. The pollen-based climate reconstruction suggests lower-than-present mean January (~−38°C) and July (~12°C) temperatures and annual precipitation (~270–300 mm) values during these time intervals. Boreal woodland replaced the primarily open landscape around Kotokel three times at about 14.8–14.7 kyr BP, during the Allerød Interstadial between 13.3–12.8 kyr BP and with the onset of the Holocene interglacial between 11.5 and 10.5 kyr BP, presumably in response to a noticeable increase in precipitation, and in July and January temperatures. The maximal spread of the boreal forest (taiga) communities in the region is associated with a warmer and wetter-than-present climate (Tw~17–18°C, Tc~−19°C, Pann~500–550 mm) that occurred ca. 10.8–7.3 kyr BP. During this time interval woody vegetation covered more than 50% of the area within a 21×21 km window around the lake. The pollen-based best modern analogue reconstruction suggests a decrease in woody cover percentages and in all climatic variables about 7–6.5 kyr BP. Our results demonstrate a gradual decrease in precipitation and mean January temperature towards their present-day values in the region around Lake Kotokel since that time.
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Tarasov, P. E., E. V. Bezrukova und S. K. Krivonogov. „Late Glacial and Holocene changes in vegetation cover and climate in southern Siberia derived from a 15 kyr long pollen record from Lake Kotokel“. Climate of the Past Discussions 5, Nr. 1 (14.01.2009): 127–51. http://dx.doi.org/10.5194/cpd-5-127-2009.
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Abstract. In this study a radiocarbon-dated pollen record from Lake Kotokel (52°47´ N, 108°07´ E, 458 m a.s.l.) located in southern Siberia east of Lake Baikal was used to derive quantitative characteristics of regional vegetation and climate since about 15 kyr BP (1 kyr=1000 cal. yr) until today. Quantitative reconstruction of the late glacial vegetation and climate dynamics suggests that open steppe and tundra communities predominated in the study area prior to ca. 13.5 kyr BP and again during the Younger Dryas interval, between 12.8 and 11.6 kyr BP. The pollen-based climate reconstruction suggests lower-than-present mean January (~–38°C) and July (~12°C) temperatures and annual precipitation (~270–300 mm) values during these time intervals. Boreal woodland replaced the primarily open landscape around Kotokel three times at about 14.8–14.7 kyr BP, during the Allerød Interstadial between 13.3–12.8 kyr BP and with the onset of the Holocene interglacial between 11.5 and 10.5 kyr BP, presumably in response to a noticeable increase in precipitation, and in July and January temperatures. The maximal spread of the boreal forest (taiga) communities in the region is associated with a warmer and wetter-than-present climate (Tw~17–18°C, Tc~–19°C, Pann~500–550 mm) occurred ca.\\ 10.8–7.3 kyr BP. During this time interval woody vegetation covered more than 50% of the area within a 21×21 km window around the lake. The pollen-based best modern analogue reconstruction suggests a decrease in woody cover percentages and in all climatic variables about 7–6.5 kyr BP. Since that time our results demonstrate gradual decrease in precipitation and mean January temperature towards their present-day values in the region around Lake Kotokel.
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Hippen, Keli L., Margaret L. MacMillan, Amanda Lemire, Asim Saha, Eric Hanse, Colin Lord, Ameeta Kelekar et al. „In Vitro Induction of Human Regulatory T-Cells (iTregs) Using Conditions of Low Tryptophan Plus Kynurenines“. Blood 128, Nr. 22 (02.12.2016): 1229. http://dx.doi.org/10.1182/blood.v128.22.1229.1229.
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Abstract Thymic regulatory T cells (tTreg) or in vitro induced Tregs (iTregs) adoptive transfer suppresses murine acute graft-versus-host disease (GVHD). Previously we demonstrated that plasmacytoid dendritic cell (pDC) indoleamine 2,3-dioxygenase (IDO) fosters the development of human iTregs through tryptophan (Trp) depletion and production of catabolites including kynurenines (Kyn). IDO is an immunosuppressive enzyme implicated in maternal-fetal acceptance, tumor immunity, and autoimmunity. IDO is highly up-regulated in the colon of mice and patients with GVHD; in rodents, the lack of IDO leads to increased colon pathology and accelerated lethality. Because pDCs are rare and difficult to purify and expand, we sought to determine whether an optimally suppressive iTreg could be generated using clinically amenable conditions that mimicked pDCs support (i.e. Low Trp+Kyn). Naïve human CD4+ T cells purified with cGMP-compatible reagents and expanded in vitro using an anti-CD3-loaded artificial APC expressing CD86 under conditions of low Trp + kynurenines suppress in vitro T cell proliferation equivalently to tTreg (A) (Fig 1). The calculated yield of Low Trp+Kyn iTreg (~1x1010) produced from an apheresis product is ~10-fold greater than similarly expanded cord blood-derived tTreg that decreased GVHD severity in the clinic (B). Low Trp+Kyn iTreg have a phenotype distinct from tTreg, including: higher CD25 expression, lower Foxp3 expression, and no Helios expression (consistent with the non-thymus origin of iTregs) (C). Since Trp depletion was important for iTreg generation, we determined whether iTregs were under metabolic stress. Surprisingly, bioenergetics profiling demonstrated that Low Trp+Kyn iTreg maintain a remarkably high metabolic rate, with both oxidative phosphorylation and glycolytic pathways higher than that observed in expanded Teffectors (Teff) and tTregs (D). High metabolic rates had functional consequences, as Low Trp+Kyn iTreg were exquisitely dependent on IL-2, which drives the expression of genes needed for glycolytic metabolism. In addition, high basal oxidative phosphorylation rates correlated with increased mitochondrial membrane potential and ROS production (not shown) and decreased viability. A xenogeneic model of GVHD was used to assess the in vivo efficacy of Low Trp+Kyn iTreg. Because Low Trp+Kyn iTreg were so sensitive to IL-2 withdrawal in vitro, mice were also treated ± low dose IL-2 for 9 days (IP, 25kU/day). While low dose IL-2 prolonged in vivo Low Trp+Kyn iTreg persistence and improved survival compared to no IL-2, survival was not significantly increased compared to GVHD mice receiving only PBMC (E). To determine whether increasing the duration of IL-2 therapy would further increase Low Trp+Kyn iTreg persistence and efficacy, the experiment was repeated (with the addition of a cohort of mice receiving PBMC + IL-2 only), and IL-2 treatment was continued indefinitely (F). However, prolonged IL-2 therapy enhanced Teff expansion, and all animals receiving exogenous IL-2 (either PBMC only or with Low Trp+Kyn iTreg) were deceased by day 18. Studies are in progress to determine whether lower doses of IL2 (i.e. 2.5 or 10k U/day) can preferentially foster iTreg expansion and efficacy in suppressing xenogeneic GVHD over Teff expansion and exacerbation of disease. Figure 1. tTreg and naïve CD4+ T-cells were purified from apheresis products using magnetic beads, stimulated with a cell line expressing CD86 and CD64 (KT64/86) to which anti-CD3 mAb is bound, and cultured for 14 days. Low Trp+Kyn iTreg (and Teff) were re-stimulated on day 7. (A) Suppressive function was determined using a CFSE-based proliferation assay at 1:16 (expanded cell:PBMC) and stimulated with anti-CD3 mAb beads for 4 days. (B) Calculated yield of tTreg and Low Trp+Kyn iTreg from a 12 billion cell apheresis product. (C) Representative expression of CD25, Foxp3, and Helios. (D) Representative metabolic analysis showing oxygen consumption rate and extracellular acidification rate for tTreg Low Trp+Kyn iTreg and Teff. (E) Kaplan-Meier survival curves for mice receiving expanded tTreg, and Low Trp+Kyn iTregs and an equal number of HLA-mismatched PBMC. Low dose IL-2 was administered to a cohort of mice receiving iTreg. Mice were bled on day 6 and tTreg and iTreg in circulation quantitated by flow. (F) As in E, but IL-2 given to cohorts of mice receiving PBMC only or PBMC + iTreg for 18 days (n=8 per cohort). Figure 1. tTreg and naïve CD4+ T-cells were purified from apheresis products using magnetic beads, stimulated with a cell line expressing CD86 and CD64 (KT64/86) to which anti-CD3 mAb is bound, and cultured for 14 days. Low Trp+Kyn iTreg (and Teff) were re-stimulated on day 7. (A) Suppressive function was determined using a CFSE-based proliferation assay at 1:16 (expanded cell:PBMC) and stimulated with anti-CD3 mAb beads for 4 days. (B) Calculated yield of tTreg and Low Trp+Kyn iTreg from a 12 billion cell apheresis product. (C) Representative expression of CD25, Foxp3, and Helios. (D) Representative metabolic analysis showing oxygen consumption rate and extracellular acidification rate for tTreg Low Trp+Kyn iTreg and Teff. (E) Kaplan-Meier survival curves for mice receiving expanded tTreg, and Low Trp+Kyn iTregs and an equal number of HLA-mismatched PBMC. Low dose IL-2 was administered to a cohort of mice receiving iTreg. Mice were bled on day 6 and tTreg and iTreg in circulation quantitated by flow. (F) As in E, but IL-2 given to cohorts of mice receiving PBMC only or PBMC + iTreg for 18 days (n=8 per cohort). Disclosures Hippen: University of Minnesota: Other: holds patents for the production and use of iTregs for clinical trials. Riley:Tmunity Therapeutics: Equity Ownership, Membership on an entity's Board of Directors or advisory committees; University of Pennsylvania: Patents & Royalties: hold patents for the production and use of iTregs for clinical trials. June:Pfizer: Honoraria; Celldex: Consultancy, Equity Ownership; Tmunity: Equity Ownership, Other: Founder, stockholder ; Johnson & Johnson: Research Funding; Novartis: Honoraria, Patents & Royalties: Immunology, Research Funding; Immune Design: Consultancy, Equity Ownership; University of Pennsylvania: Patents & Royalties. Kean:Juno Therapeutics, Inc: Research Funding. Miller:Fate Therapeutics: Consultancy, Research Funding; Oxis Biotech: Consultancy, Other: SAB.
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Müller, S., P. E. Tarasov, A. A. Andreev und B. Diekmann. „Late Glacial to Holocene environments in the present-day coldest region of the Northern Hemisphere inferred from a pollen record of Lake Billyakh, Verkhoyansk Mts, NE Siberia“. Climate of the Past Discussions 4, Nr. 6 (26.11.2008): 1237–64. http://dx.doi.org/10.5194/cpd-4-1237-2008.
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Abstract. In this study a radiocarbon-dated pollen record from Lake Billyakh (65°17'N, 126°47'E; 340 m a.s.l.) in the Verkhoyansk Mountains was used to reconstruct vegetation and climate change since about 15 kyr BP (1 kyr=1000 cal. yr). The pollen record and pollen-based biome reconstruction suggest that open cool steppe and grass and sedge tundra communities with Poaceae, Cyperaceae, Artemisia, Chenopodiaceae, Caryophyllaceae and Selaginella rupestris dominated the area from 15 to 13.5 kyr BP. On the other hand, the constant presence of Larix pollen in quantities comparable to today's values points to the constant presence of boreal deciduous conifer trees in the regional vegetation during the last glaciation. A major spread of shrub tundra communities, including birch (Betula sect. Nanae), alder (Duschekia fruticosa) and willow (Salix) species, is dated to 13.5–12.7 kyr BP, indicating a noticeable increase in precipitation toward the end of the last glaciation, particularly during the Allerød Interstadial. Between 12.7 and 11.4 kyr BP pollen percentages of herbaceous taxa rapidly increased, whereas shrub taxa percentages decreased, suggesting strengthening of the steppe communities associated with the relatively cold and dry Younger Dryas Stadial. However, the pollen data in hand indicate that Younger Dryas climate was less severe than the climate during the earlier interval from 15 to 13.5 kyr BP. The onset of the Holocene is marked in the pollen record by the highest values of shrub and lowest values of herbaceous taxa, suggesting a return of warmer and wetter conditions after 11.4 kyr BP. Percentages of tree taxa increase gradually and reach maximum values after 7 kyr BP, reflecting the spread of boreal cold deciduous and taiga forests in the region. An interval between 7 and 2 kyr BP is noticeable for the highest percentages of Scots pine (Pinus subgen. Diploxylon), spruce (Picea) and fir (Abies) pollen, indicating mid-Holocene spread of boreal forest communities in response to climate amelioration and degradation of the permafrost layer.
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Müller, S., P. E. Tarasov, A. A. Andreev und B. Diekmann. „Late Glacial to Holocene environments in the present-day coldest region of the Northern Hemisphere inferred from a pollen record of Lake Billyakh, Verkhoyansk Mts, NE Siberia“. Climate of the Past 5, Nr. 1 (06.03.2009): 73–84. http://dx.doi.org/10.5194/cp-5-73-2009.
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Abstract. In this study, a radiocarbon-dated pollen record from Lake Billyakh (65°17' N, 126°47' E; 340 m a.s.l.) in the Verkhoyansk Mountains was used to reconstruct vegetation and climate change since about 15 kyr BP. The pollen record and pollen-based biome reconstruction suggest that open cool steppe (STEP) and grass and sedge tundra (TUND) communities with Poaceae, Cyperaceae, Artemisia, Chenopodiaceae, Caryophyllaceae and Selaginella rupestris dominated the area from 15 to 13.5 kyr BP. On the other hand, the constant presence of Larix pollen in quantities comparable to today's values points to the constant presence of boreal deciduous conifer (CLDE) trees in the regional vegetation during the Late Glacial. A major spread of shrub tundra communities, including birch (Betula sect. Nanae), alder (Duschekia fruticosa) and willow (Salix) species, is dated to 13.5–12.7 kyr BP, indicating a noticeable increase in precipitation toward the end of the Last Glaciation, particularly during the Bølling-Allerød Interstadial. Between 12.7 and 11.4 kyr BP pollen percentages of herbaceous taxa rapidly increased, whereas shrub taxa percentages decreased, suggesting strengthening of the steppe communities associated with the relatively cold and dry Younger Dryas Stadial. However, the pollen data in hand indicate that Younger Dryas climate was less severe than the climate during the earlier interval from 15 to 13.5 kyr BP. The onset of the Holocene is marked in the pollen record by the highest values of shrub and lowest values of herbaceous taxa, suggesting a return of warmer and wetter conditions after 11.4 kyr BP. Percentages of tree taxa increase gradually and reach maximum values after 7 kyr BP, reflecting the spread of boreal cold deciduous and taiga forests in the region. An interval between 7 and 2 kyr BP is noticeable for the highest percentages of Scots pine (Pinus subgen. Diploxylon), spruce (Picea) and fir (Abies) pollen, indicating mid-Holocene spread of boreal forest communities in response to climate amelioration and degradation of the permafrost layer.
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Guimarães, Deborah Vogelsanger. „JOHREI E O ESPÍRITO DA PALAVRA“. Revista Relicário 8, Nr. 15 (23.09.2021): 71–85. http://dx.doi.org/10.46731/relicario-v8n15-2021-186.
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O Johrei é uma prática distintiva da Igreja Messiânica Mundial do Brasil (IMMB) que se refere ao bem-estar físico, mas especialmente ao bem-estar espiritual. Entendido e praticado pelos membros da IMMB como uma forma de cura espiritual e material, o Johrei se caracteriza pela transmissão de energia espiritual por imposição de mãos e guarda, em sua elaboração conceitual, um elemento filosófico e teológico importante: a força espiritual das palavras. É sobre isso o artigo que agora apresento.
Palavras-chave: Sekai Kyusei-Kyo, Johrei, Filosofia da Religião
Abstract: Johrei is a distinctive Igreja Messiânica Mundial do Brasil (IMMB)'s practice, which refers to physical well-being, yet especially spiritual one. Understood and practiced by IMMB members as a form of spiritual and material healing, Johrei is characterized by the transmission of spiritual energy by laying on of hands and guarding, in its conceptual elaboration, an important philosophical and theological element: the spiritual force of speech. This is the subject of the below essay.
Keywords: Sekai Kyusei-Kyo, Johrei, Philosophy of Religion
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Ji, Bing, Yuan-yuan Li, Wei-ji Yang, Li-zong Zhang, Ming-sun Fang, Hui-ying Fu und Qi-yang Shou. „Jinkui Shenqi Pills Ameliorate Asthma with “Kidney Yang Deficiency” by Enhancing the Function of the Hypothalamic-Pituitary-Adrenal Axis to Regulate T Helper 1/2 Imbalance“. Evidence-Based Complementary and Alternative Medicine 2018 (2018): 1–10. http://dx.doi.org/10.1155/2018/7253240.
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The aim of the study was to investigate the effects and underlying mechanism of JKSQP in a rat model of asthma with kidney-yang deficiency (KYD). Materials and Methods. Hydrocortisone (HYD) was used to establish the rat model of KYD; rats were then sensitized and challenged with ovalbumin (OVA). JKSQP was administered to OVA-challenged rats, and the changes in signs and symptoms of KYD were observed. The leukocyte number and subpopulations in bronchoalveolar lavage fluid (BALF) were counted and the cells were stained with Wright–Giemsa dye. Serum adrenocorticotropic hormone (ACTH), corticosterone (CORT), corticotropin-releasing hormone (CRH), total immunoglobulin E (IgE), and OVA-specific IgE levels were determined using relevant enzyme-linked immunosorbent assays (ELISA) kits. Results. JKSQP not only reversed the phenomenon of KYD but also significantly inhibited the number of leukocyte and eosinophils in the BALF, increasing the level of interferon (IFN)-γ and decreasing the levels of interleukin-4 (IL-4) and IgE in the serum compared with the OVA-challenged groups. Conclusions. Taken together, the antiasthma effects of JKSQP were likely mediated by the enhancement of the function of the hypothalamic-pituitary-adrenal axis and the reversal of T helper 1/2 imbalance.
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Brahimi, Fouad, Philippe Bertrand, Marjorie Starck, Marie-Madeleine Galteau und G�rard Siest. „Control of apolipoprotein E secretion in the human hepatoma cell line KYN-2“. Cell Biochemistry and Function 19, Nr. 1 (2001): 51–58. http://dx.doi.org/10.1002/cbf.899.
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Pye, Michael. „Refletindo sobre primos distantes: distância cultural na transplantação de religiões japonesas em outros países“. Revista de Estudos da Religião (REVER). ISSN 1677-1222 11, Nr. 2 (06.01.2012): 11. http://dx.doi.org/10.21724/rever.v11i2.8130.
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Este artigo leva em consideração a questão da “distância cultural” na transplantação de religiões japonesas em países distantes, isto é, em países que são distantes do Japão, geográfica e culturalmente. Em particular, o texto se refire a exemplos selecionados daquilo que no Japão é considerado “novas religiões”, tais como, Omotokyo, Sekai Kyuseikyo, Seicho-no-iê, Shinnyoen, Tenrikyô e Tensho Kotai Jingu Kyo, são bastante ativas no Brasil.
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Repkina, T. Yu, Y. A. Kublitsky, P. A. Leontev, A. L. Gurinov, E. A. Vakhrameeva, G. N. Losyuk, O. S. Shilova und N. N. Lugovoy. „The relative sea level changes and aeolianprocesses on the Eastern coast of the White Sea (Gorlo Strait) during the Late Glacial and Holocene (based on studies of Lake SrednyayaTret )“. Limnology and Freshwater Biology, Nr. 4 (2022): 1544–46. http://dx.doi.org/10.31951/2658-3518-2022-a-4-1544.
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Abstract. Geomorphological, ground penetration radar profiling and paleolimnological investigations were carried out in the Lake SrednyayaTret (66.014009 N, 41.086294 E; 7.3 m ASL). Bottom sediments from the three boreholes were studied. Lithologostratigraphic description, grain-size and diatom analyses were carried out, loss on ignition, Corg/Nogr was determined. Radiocarbon ages were obtained from the lower horizons of post-glacial sediments. Signs of Late Glacial transgression (earlier ~12.1 kyr. cal. BP) and Early Holocene regression (started between ~12.1 and ~10.3 kyr. cal. BP) were determined. The next filling of the lake basin can be compared with the Middle Holocene transgression. At the same time sea waters did not penetrate into the lake basin. The beginning of this stage was apparently accompanied by intensification of coastal aeolian processes.
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Shang, Qi, Wenhua Zhao, Gengyang Shen, Xiang Yu, Zhida Zhang, Xuan Huang, Weicheng Qin et al. „Jingui Shenqi Pills Regulate Bone-Fat Balance in Murine Ovariectomy-Induced Osteoporosis with Kidney Yang Deficiency“. Evidence-Based Complementary and Alternative Medicine 2020 (07.09.2020): 1–9. http://dx.doi.org/10.1155/2020/1517596.
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Jingui Shenqi Pills (JGSQP) have been a staple of traditional Chinese medicine for thousands of years, used primarily as a treatment for kidney yang deficiency (KYD). In vitro analyses of JGSQP revealed strong induction of osteogenic differentiation and inhibition of adipogenic differentiation in bone-marrow-derived mesenchymal stem/stromal cells. However, the mechanisms by which JGSQP regulate the bone-fat balance in murine ovariectomy-induced osteoporosis with KYD have not been reported. Materials and Methods. Two-month-old female C57BL/6 mice were divided randomly into three groups: those receiving a sham operation (Sham); those undergoing bilateral ovariectomy and selection of KYD syndrome (Model); and those subjected to both bilateral ovariectomy and KYD syndrome selection for 8 weeks, followed by JGSQP treatment for 4 weeks (JGSQP). In the Sham and Model groups, mice were given the same dose of distilled water orally for 4 weeks. Animals from all three groups were euthanised at the 12th week. Vertebral microarchitecture and histomorphology were examined by micro-CT and H&E staining, respectively. In addition, we examined the mRNA expression of Akt, Wnt10b, Osterix (Osx), Fndc5, PPARγ, and Fabp4, as well as the protein of AKT, phosphorylation-AKT (p-AKT), BMP2, COL1A1, and FNDC5. Results. JGSQP treatment improved bone microarchitecture and mitigated histomorphological damage relative to the Model group. The osteoblast number (Ob.N/BS) and area (Ob.S/BS) were increased, whereas adipocyte number (adipocyte/tissue area) and area (adipocyte area/tissue area) were decreased in the JGSQP group. JGSQP treatment reduced the mRNA expression of Akt and adipogenesis-related genes (Fndc5, PPARγ, and Fabp4) while promoting osteogenesis-related genes (Wnt10b and Osx) mRNA expression. Additionally, the expression of p-AKT, BMP2, and COL1A1 proteins was increased and FNDC5 protein expression was decreased after JGSQP treatment. Conclusions. JGSQP treatment reversed murine ovariectomy-induced osteoporosis with KYD by controlling bone-fat balance via AKT pathway.
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Verkulich, Sergey R., und Achim Hiller. „Holocene deglaciation of the Bunger Hills revealed by 14C measurements on stomach oil deposits in snow petrel colonies“. Antarctic Science 6, Nr. 3 (September 1994): 395–99. http://dx.doi.org/10.1017/s0954102094000593.
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Solidified stomach oil deposits in snow petrel colonies in the Antarctic proved to be suitable for 14C dating and provide important palaeobiogeographical and palaeoenvironmental information. Following earlier studies in the Untersee oasis (Central Dronning Maud Land) we present here 14C measurements on comparable deposits from the Bunger Hills (66°10′S, 101°E). The conventional 14C age of the basal layer reflects the occupation age of any particular nesting site and therefore a minimum age for the time when this area became ice-free. According to the 14C results the occupation of the southern part of the Bunger Hills by petrels started about 10000yr ago. The breeding colonies expanded continuously following local ice retreat. The most intensive phases of colonization seem to have been from 8–6 kyr BP and during the past 2 kyr.
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Shilowaras, Mahendran, und Nor Amizam Jusoh. „Implementing Artificial Intelligence Chatbot in Moodle Learning Management System“. Engineering, Agriculture, Science and Technology Journal (EAST-J) 1, Nr. 1 (02.08.2022): 70–75. http://dx.doi.org/10.37698/eastj.v1i1.122.
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Learning Management System (LMS) is a software application or web-based technology that is used to develop, implement, and evaluate a specific learning process. KYP has implemented an e-Learning Management System (e-LMS) using Moodle since early 2021. The main features already implemented in this e-LMS is course details and it should also support the communication process between lecturers and students where currently, the KYP e-LMS lack of. Usually, students will ask the same question to their lecturer in person and cause the lecturer to have to give the same answers repeatedly. This results in a waste of time for both parties in answering and receiving answers. To overcome the problem, there is a need to replace the manual way of getting answers to any kind of academic or course related questions repeatedly. The main objective of the project is to develop an intelligence Chatbot which can help students finding academic related information without the need to ask their instructors or spent more time browsing menus in e-LMS. E-LMS has been developed based on Rational Unified Process (RUP) approach. In this project, the Moodle system is fully implemented by integrating with Kommunicate, one of the Cloud software and Dialog Flow, which is a chatbot plugin system connected with Google Could Platform. An AI Chatbot able to interact with students and can provide answer to students' queries instantly despite of the place, date and time zone of the student as well as enhances interaction which provides a feel of support to the students.
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Guimarães, Deborah Vogelsanger. „ORAÇÕES E CÂNTICOS:“. Revista Relicário 9, Nr. 17 (31.08.2022): 93–112. http://dx.doi.org/10.46731/relicario-v9n17-2022-222.
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As orações Amatsu Norito e Zenguen Sandji são usadas pela Sekai Kyusei-Kyo, uma nova religião japonesa fundada no Japão na década de 1930 por Mokichi Okada. A partir da comparação entre os sentidos destas orações para japoneses (entendidos como o conjunto dos japoneses tradicionais não-cristãos) e ocidentais (no conjunto dos cristãos) fez-se uma abordagem hermenêutica de seu contexto na perspectiva da religião como dimensão da vida espiritual humana. No que diz respeito à saúde, Okada cria o conceito de Johrei como ato purificador tanto do corpo como do espírito.
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Pavlov, Pavel. „The Main Stages and Specific Features of the Initial Peopling of the Northeast of East European Plain and the Urals at the Beginning of the Upper Palaeolithic“. Stratum plus. Archaeology and Cultural Anthropology, Nr. 1 (27.02.2022): 129–49. http://dx.doi.org/10.55086/sp221129149.
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The article discusses the materials of the Early Upper Paleolithic sites of Zaozer’e, Garchi I and Byzovaya situated in the northeast of the East European plain and on the Urals (58—67°N; 50—60°E), in the Pechora and Upper Kama river basins. In this region, two episodes of initial human occupation are recognizable. The first (Zaozer’e site, 35—33 kyr BP) may represent the earliest penetration of anatomically modern humans into the north of Europe, while the second one (Garchi I and Byzovaya sites, ca. 29 kyr BP) can be associated with the migration of some Streletskian populations to the northeast of the European continent. The available ecidence seems to indicate the cultural and chronological unity in the development of Paleolithic culture in the center and the northeast of the East European plain and on the Urals in the first half of the Upper Palaeolithic.
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Arruda, Felipe. „Budismo e natureza“. Sacrilegens 17, Nr. 2 (31.12.2020): 82–96. http://dx.doi.org/10.34019/2237-6151.2020.v17.32691.
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Os ensinamentos budistas são tradicionalmente divididos em três grandes classes, comumente conhecidas como os “Três Giros da Roda do Dharma” (Tib. chos kyi ‘khor lo bskor gsum), constituindo-se como caminhos espirituais distintos, denominados “veículos” (Skt. yāna, Tib. theg). O presente artigo tem como objetivo investigar as perspectivas específicas destes três veículos acerca da natureza, suas singularidades e atribuições, assim como uma possível complementaridade entre as abordagens dos mesmos.
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Miao, Vivian, Marie-Françoise Coëffet-LeGal, Paul Brian, Renee Brost, Julia Penn, Andrew Whiting, Steven Martin et al. „Daptomycin biosynthesis in Streptomyces roseosporus: cloning and analysis of the gene cluster and revision of peptide stereochemistry“. Microbiology 151, Nr. 5 (01.05.2005): 1507–23. http://dx.doi.org/10.1099/mic.0.27757-0.
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Daptomycin is a 13 amino acid, cyclic lipopeptide produced by a non-ribosomal peptide synthetase (NRPS) mechanism in Streptomyces roseosporus. A 128 kb region of S. roseosporus DNA was cloned and verified by heterologous expression in Streptomyces lividans to contain the daptomycin biosynthetic gene cluster (dpt). The cloned region was completely sequenced and three genes (dptA, dptBC, dptD) encoding the three subunits of an NRPS were identified. The catalytic domains in the subunits, predicted to couple five, six or two amino acids, respectively, included a novel activation domain and amino-acid-binding pocket for incorporating the unusual amino acid l-kynurenine (Kyn), three types of condensation domains and an extra epimerase domain (E-domain) in the second module. Novel genes (dptE, dptF) whose products likely work in conjunction with a unique condensation domain to acylate the first amino acid, as well as other genes (dptI, dptJ) probably involved in supply of the non-proteinogenic amino acids l-3-methylglutamic acid and Kyn, were located next to the NRPS genes. The unexpected E-domain suggested that daptomycin would have d-Asn, rather than l-Asn, as originally assigned, and this was confirmed by comparing stereospecific synthetic peptides and the natural product both chemically and microbiologically.
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Resch, Dustin. „Living in Union with Christ: The Practical Theology of Thomas E Torrance, by Kye Won Lee“. Arc: The Journal of the School of Religious Studies 32 (01.05.2007): 286–88. http://dx.doi.org/10.26443/arc.v32i.1061.
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Wang, Hongchao, Yuan He, Danting Dang, Yurong Zhao, Jianxin Zhao und Wenwei Lu. „Gut Microbiota-Derived Tryptophan Metabolites Alleviate Allergic Asthma Inflammation in Ovalbumin-Induced Mice“. Foods 13, Nr. 9 (26.04.2024): 1336. http://dx.doi.org/10.3390/foods13091336.
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Asthma is a prevalent respiratory disease. The present study is designed to determine whether gut microbiota-derived tryptophan metabolites alleviate allergic asthma inflammation in ovalbumin (OVA)-induced mice and explore the effect and potential mechanism therein. Asthma model mice were constructed by OVA treatment, and kynurenine (KYN), indole-3-lactic acid (ILA), in-dole-3-carbaldehyde (I3C), and indole acetic acid (IAA) were administered by intraperitoneal injection. The percent survival, weight and asthma symptom score of mice were recorded. The total immunoglobulin E and OVA-specific (s)IgE in the serum and the inflammatory cytokines in the bronchoalveolar lavage fluid (BALF) were detected by the corresponding ELISA kits. The composition of the gut microbiota and tryptophan-targeted metabolism in mouse feces were analyzed using 16S rRNA gene sequencing and targeted metabolomics, respectively. The four tryptophan metabolites improved the percent survival, weight and asthma symptoms of mice, and reduced the inflammatory cells in lung tissues, especially I3C. I3C and IAA significantly (p < 0.05) downregulated the levels of OVA-IgE and inflammatory cytokines. KYN was observed to help restore gut microbiota diversity. Additionally, I3C, KYN, and ILA increased the relative abundance of Anaeroplasma, Akkermansia, and Ruminococcus_1, respectively, which were connected with tryptophan metabolic pathways. IAA also enhanced capability of tryptophan metabolism by the gut microbiota, restoring tryptophan metabolism and increasing production of other tryptophan metabolites. These findings suggest that tryptophan metabolites may modulate asthma through the gut microbiota, offering potential benefits for clinical asthma management.
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Corrêa Magalhães, Breno. „Igreja Messiânica Mundial: compreendendo cisões e dissidências a partir de suas características singulares“. Sacrilegens 18, Nr. 2 (30.01.2022): 288–307. http://dx.doi.org/10.34019/2237-6151.2021.v18.34897.
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Novos Movimentos Religiosos (NMR) estão presentes no campo religioso brasileiro sobretudo a partir da década de 1970. Soka Gakkai, Sekai Kyusei Kyo (Igreja Messiânica Mundial) e Seicho No Ie são exemplos de movimentos, conhecidos no Japão como Novas Religiões Japonesas (NRJ), que se desenvolveram neste período. A transplantação destas instituições foi fenômeno amplamente pesquisado, contudo, passada a crista da onda de expansão das NRJ uma classificação conceitual que as caracterize pode contribuir para melhor compreensão de um fenômeno recorrente entre elas: as cisões e formação de dissidências. Este artigo tem por objetivo apresentar elementos para esta análise tomando como referência o caso da IMM.
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Al-Husseini, Moujahed I. „Arabian Orbital Stratigraphy revisited – AROS 2015“. GeoArabia 20, Nr. 4 (01.10.2015): 183–216. http://dx.doi.org/10.2113/geoarabia2004183.
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ABSTRACT ‘Arabian Orbital Stratigraphy’ (AROS) is an R&D program aimed at dating Arabia’s transgressive-regressive (T-R) depositional sequences using the ‘Orbital Scale’ of Matthews and Al-Husseini (2010). The scale consists of time-rock units named ‘orbitons’, ‘dozons’ and ‘stratons’ that are tuned by orbital-forcing of glacio-eustasy. Orbitons have durations of 14.58 million years (Myr), and are bounded by regional sequence boundaries (SB, hiatus, unconformity, disconformity, lowstand deposits). Orbiton 1 was deposited between SB 1 at 16.166 million years before present (Ma) and SB 0 (zero) at 1.586 Ma. The interval between SB 0 and the Precambrian/Cambrian Boundary (PCB) consists of 37 orbitons; at least 30 can be identified in Arabia based on published data. SB 37 is predicted at 541.046 Ma (1.586 + 37 × 14.58 Myr), and correlates to the PCB, calibrated in Oman at 541.0 Ma. An orbiton consists of 36 stratons. Stratons are T-R sequences that tracked the long-eccentricity orbital cycle (E-cycle). The age of base Straton 1 is 0.371 Ma. Their durations can range between about 300 thousand years (Kyr) and 550 Kyr, but average 405 Kyr over several million years. The Phanerozoic Era consists of 1,336 stratons that are typically referred to as 4th-order sequences or cycle sets. Approximately 200 stratons are identified in this paper, and tentatively dated in the Orbital Scale. An orbiton also consists of three dozons, which are generally bounded by regional SBs. Dozons typically consist of 12 stratons (4.86 Myr). Examples of dozons are illustrated in this paper for the Permian–Triassic in Arabia. AROS predicts ages for Arabian and global T-R sequences that are deterministic, and they may be more accurate than those estimated by the Geological Time Scale GTS 2015. The paper proposes that the global T-R sequences should be recast in terms of stratons (E-cycles), and that stratons be used to calibrate biostratigraphy, magneto-stratigraphy and other global stratigraphic markers in future GTSs.
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Poga, Man. „Profili i një atdhetari të lënë në hije“. Diskutime 7, Nr. 23 (07.02.2023): 397–407. http://dx.doi.org/10.58923/diskutime.v7i23.592.
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Ky punim ka për qëllim të ndriçojë sadopak një nga figurat historike që kontribuoi gjatë shekullit XIX-XX për çështjen kombëtare shqiptare. Evidentimin e aktivitetit të tij atdhetar, rolin kyç në mbështetjen e kryengritjes antiosmane sidomos gjatë viteve 1900-1912, në verilindje të Shqipërisë. Hazir Kurpali kishte arritur që të themelonte e drejtonte që në moshë të re një çetë mjaft aktive e cila la gjurmë të pashlyeshme në kronikat e kohës e ku aktiviteti i dendur luftarak në koordinim me ideologët e patriotët e lëvizjen kombëtare si Hasan Prishtina, Bajram e Hysni Curri, Isa Boletini, Azem e Shote Galica, shtrihej që nga Hasi, me luftën e Qaf-Prushit, beteja e Gjakovës, Decanit, Plavë-Guci, beteja e përgjakshme e Kaçanikut e deri në Shkup. Profili i tij fatkeqësisht është pak i njohur dhe është lënë në hije, pavarësisht nga kontributi që dëshmohet nëpërmjet dokumenteve, fotove, kujtimeve e studimeve të bashkëkohësve. Nën drejtimin e tij gjetën besim e u bashkuan shumë të rinj e patriotë jo vetëm nga Hasi, prej nga ishte Hazir Kurpali por dhe nga Malësia, Deçani, Gjakova e shumë treva të tjera të Kosovës, fakt që flet për shtrirjen e gjerë të influencës së tij.
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Sahebjam, Solmaz, Jameel Muzaffar, Timothy Yap, David Hong, Olivier Rixe, Ursa Brown-Glaberman, Andreea Varga et al. „287 Safety and antitumor activity of indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor KHK2455 in combination with anti-CCR4 monoclonal antibody mogamulizumab in patients with advanced solid tumors“. Journal for ImmunoTherapy of Cancer 8, Suppl 3 (November 2020): A313—A314. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0287.
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BackgroundIDO-1 inhibitors have shown antitumor activity in combination with immunotherapeutic agents in multiple cancers. KHK2455 is a novel and selective oral IDO-1 inhibitor. KHK2455 inhibits IDO-1 apo-enzyme, with long-lasting and potent activity. Mogamulizumab is an anti-C-C chemokine receptor 4 (CCR4) monoclonal antibody that has shown synergy with KHK2455 in preclinical models. Mogamulizumab is approved in the US and EU for treatment of mycosis fungoides and Sézary syndrome.MethodsIn this first-in-human study, patients with advanced solid tumors received escalating oral doses of KHK2455 alone (0.3, 1, 3, 10, 30 and 100 mg once daily) for 4 weeks (Cycle 0), followed by combination with 1 mg/kg weekly of IV mogamulizumab for 4 weeks (Cycle 1), and then on Days 1 and 15 (from Cycle 2 onward) in a standard 3+3 Phase I design. Safety, tolerability, pharmacokinetics and IDO activity (kynurenine [Kyn] and tryptophan [Trp] levels and ex vivo Kyn production) were evaluated.ResultsThirty-six patients were enrolled across all cohorts. One patient with lower esophageal cancer in the 100 mg cohort exhibited dose-limiting toxicity (Grade 3 gastrointestinal necrosis). The most frequent (≥10%) treatment-emergent adverse events (TEAEs) are presented in table 1. Overall numbers of TEAEs, ≥Grade 3 TEAEs, and serious TEAEs related to KHK2455 and mogamulizumab are presented in table 2. Serious KHK2455-related TEAEs included gastrointestinal necrosis (KHK2455 monotherapy), and nausea and drug eruption (combination therapy). In addition, five drug-related TEAEs in combination therapy led to discontinuation; there were no fatal outcomes related to either study drug. Plasma KHK2455 concentrations reached steady state by Day 8 (Cycle 0) and increased dose-dependently. Potent dose-dependent inhibition of IDO activity was demonstrated by plasma Kyn concentration and Kyn/Trp ratio (median inhibition 70.5% and 70.8%, respectively, at 100 mg dose on Day 15, compared to baseline) and ex vivo Kyn production (>95% inhibition at ≥10 mg KHK2455), confirming target modulation. Six of 26 evaluable patients from all dosing groups achieved durable disease stabilization (≥6 months, RECIST 1.1), and one patient with bevacizumab-resistant glioblastoma demonstrated confirmed partial response (43.5% tumor reduction over a 2-year observation period). Median overall survival was 13.4 months, with 30% of subjects surviving for 2 years or longer (figure 1).Abstract 287 Table 1Study 2455-001: Treatment-Emergent Adverse Events (≥10% by Preferred Term)Abstract 287 Table 2Abstract 287 Figure 1Study 2455-001: Overall SurvivalConclusionsKHK2455 in combination with mogamulizumab was well-tolerated and manageable at all doses tested, suppressed Kyn production in a dose-dependent and sustained manner, and demonstrated signals of antitumor activity. These data support the continued development of this combination.AcknowledgementsMedical writing assistance was provided by Susan E. Johnson, PhD, S.E. Johnson Consulting, LLC, New Hope, PA, USA.Trial RegistrationNCT02867007 (www.clinicaltrials.gov)Ethics ApprovalThis study was approved by Ethics Committees at all participating study institutions.
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Homei, Aya. „Tempos modernos, novos partos e novas parteiras: o parto no Japão de 1868 aos Anos 1930“. Revista Estudos Feministas 10, Nr. 2 (Juli 2002): 429–40. http://dx.doi.org/10.1590/s0104-026x2002000200012.
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As shin-sanba, ou 'novas parteiras' medicalizadas, que apareceram durante o período Meiji (1868-1912) no Japão, parecem ter, aos olhos atuais, substituído rapidamente e sem conflito as 'velhas parteiras' (kyû-sanba) e as cada vez mais criminalizadas 'parteiras não licenciadas' (mumenkyo-sanba), enquanto a profissão de parteira foi se desenvolvendo progressivamente como profissão médica moderna. Este artigo sugere que a história das parteiras na era moderna foi mais complexa do que aquilo que se imagina atualmente. Primeiro, o surgimento e a prosperidade das shin-sanba estiveram intrinsecamente ligados às contingências do Japão moderno e ao inter-relacionamento de vários grupos de atores históricos - autoridades da higiene, sankai (ginecologistas-obstetras), outras parteiras e 'clientes'. Segundo, ao longo da era moderna, as shin-sanba não substituíram outros tipos de parteiras; na verdade, os diferentes tipos co-existiram. Por fim, a existência e o status das parteiras dependeram em grande parte de um mercado de serviços de saúde marcado pelo laissez-faire, e as realidades desse mercado muitas vezes contradiziam a retórica médica que favorecia as shin-sanba em relação a outros tipos de parteiras.
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Nika, Ermir. „Roli patriotik e intelektual i Mehmet Pashë Derallës“. Diskutime 7, Nr. 23 (03.02.2023): 218–24. http://dx.doi.org/10.58923/diskutime.v7i23.541.
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Studimeve shqiptare, kohë pas kohe, i janë bashkëlidhur vepra dhe punime të cilat hedhin dritë dhe trajtojnë në këndvështrime të ndryshme, rolin dhe kontributin e protagonistëve të ndryshëm në dobi të çështjes kombëtare. Parë në këtë këndvështrim, shumë studiues i janë rikthyer më shumë se njëherë trajtimit të disa prej momenteve më të rëndësishme të historiografisë kombëtare. Pikërisht ky aspekt, është edhe motivi i organizimit të kësaj veprimtarie, e cila ka në qendër të objektit të saj, vlerësimin për njërin prej personaliteteve më të spikatur dhe të rëndësishëm të historisë sonë kombëtare, Mehmet Pashë Deralla. Lëvizja Kombëtare, para së gjithash duhet parë jo thjesht si një organizim mbarë shoqëror dhe si një mobilizim e strategji ushtarake, për të garantuar mbrojtjen e tërësisë territoriale në ruajtjen e integritetit të vendit, por edhe si një përpjekje intelektuale për ndërgjegjësimin mbarëshoqëror, me qëllim shpalosjen dhe konsolidimin e mëtejshëm të identitetit tonë kombëtar. E padyshim, në këtë kauzë të përbashkët, roli dhe kontributi i Mehmet Pashë Derallës ishte një faktor kyç që ndikonte drejtpërsëdrejti në përmbushjen e këtij misioni madhor për realitetin dhe ardhmërinë e ekzistencës së shqiptarëve, kulturës, historisë dhe shtetit të tyre, si pjesë përbërëse e bashkësisë ballkanike dhe evropiane.
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Burgess, Daniel A., Kaya Mori, Joseph D. Gelfand, Charles J. Hailey, Yarone M. Tokayer, Jooyun Woo, Hongjun An et al. „The Eel Pulsar Wind Nebula: A PeVatron-candidate Origin for HAWC J1826−128 and HESS J1826−130“. Astrophysical Journal 930, Nr. 2 (01.05.2022): 148. http://dx.doi.org/10.3847/1538-4357/ac650a.
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Abstract HAWC J1826−128 is one of the brightest Galactic TeV γ-ray sources detected by the High Altitude Water Cherenkov (HAWC) observatory, with photon energies extending up to nearly ∼100 TeV. This HAWC source spatially coincides with the H.E.S.S. TeV source HESS J1826−130 and the “Eel” pulsar wind nebula (PWN), which is associated with the GeV pulsar PSR J1826−1256. In the X-ray band, Chandra and XMM-Newton revealed that the Eel PWN is composed of both a compact nebula (∼15″) and diffuse X-ray emission (∼6′ × 2′) extending away from the pulsar. Our NuSTAR observation detected hard X-ray emission from the compact PWN up to ∼20 keV and evidence of the synchrotron burn-off effect. In addition to the spatial coincidence between HESS J1826−130 and the diffuse X-ray PWN, our multiwavelength spectral energy distribution (SED) analysis using X-ray and γ-ray data establishes a leptonic origin of the TeV emission associated with the Eel PWN. Furthermore, our evolutionary PWN SED model suggests (1) a low PWN B-field of ∼1 μG, (2) a significantly younger pulsar age (t ∼ 5.7 kyr) than the characteristic age (τ = 14.4 kyr), and (3) a maximum electron energy of E max = 2 PeV. The low B-field, as well as the putative supersonic motion of the pulsar, may account for the asymmetric morphology of the diffuse X-ray emission. Our results suggest that the Eel PWN may be a leptonic PeVatron particle accelerator powered by the ∼6 kyr old pulsar PSR J1826−1256 with a spin-down power of 3.6 × 1036 erg s−1.