Thematische Bibliographien / Dotlak

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Auswahl der wissenschaftlichen Literatur zum Thema „Dotlak“

Autor: Grafiati

Veröffentlicht am 28. Juni 2021

Zuletzt aktualisiert am 1. Februar 2022

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Zeitschriftenartikel zum Thema "Dotlak"

Zhang, Long, Lihe Chen, Chao Gao, Enuo Chen, Andrea R. Lightle, Llewellyn Foulke, Bihong Zhao, Paul J. Higgins und Wenzheng Zhang. „Loss of Histone H3 K79 Methyltransferase Dot1l Facilitates Kidney Fibrosis by Upregulating Endothelin 1 through Histone Deacetylase 2“. Journal of the American Society of Nephrology 31, Nr. 2 (16.12.2019): 337–49. http://dx.doi.org/10.1681/asn.2019070739.

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BackgroundThe progression rate of CKD varies substantially among patients. The genetic and epigenetic contributions that modify how individual patients respond to kidney injury are largely unknown. Emerging evidence has suggested that histone H3 K79 methyltransferase Dot1l has an antifibrotic effect by repressing Edn1, which encodes endothelin 1 in the connecting tubule/collecting duct.MethodsTo determine if deletion of the Dot1l gene is a genetic and epigenetic risk factor through regulating Edn1, we studied four groups of mice: wild-type mice, connecting tubule/collecting duct–specific Dot1l conditional knockout mice (Dot1lAC), Dot1l and Edn1 double-knockout mice (DEAC), and Edn1 connecting tubule/collecting duct–specific conditional knockout mice (Edn1AC), under three experimental conditions (streptozotocin-induced diabetes, during normal aging, and after unilateral ureteral obstruction). We used several approaches (colocalization, glutathione S-transferase pulldown, coimmunoprecipitation, yeast two-hybrid, gel shift, and chromatin immunoprecipitation assays) to identify and confirm interaction of Dot1a (the major Dot1l splicing variant in the mouse kidney) with histone deacetylase 2 (HDAC2), as well as the function of the Dot1a-HDAC2 complex in regulating Edn1 transcription.ResultsIn each case, Dot1lAC mice developed more pronounced kidney fibrosis and kidney malfunction compared with wild-type mice. These Dot1lAC phenotypes were ameliorated in the double-knockout DEAC mice. The interaction between Dot1a and HDAC2 prevents the Dot1a-HDAC2 complex from association with DNA, providing a counterbalancing mechanism governing Edn1 transcription by modulating H3 K79 dimethylation and H3 acetylation at the Edn1 promoter.ConclusionsOur study confirms Dot1l to be a genetic and epigenetic modifier of kidney fibrosis, reveals a new mechanism regulating Edn1 transcription by Dot1a and HDAC2, and reinforces endothelin 1 as a therapeutic target of kidney fibrosis.

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Meikle, Thomas G., Calum J. Drummond und Charlotte E. Conn. „Microfluidic Synthesis of Rifampicin Loaded PLGA Nanoparticles and the Effect of Formulation on their Physical and Antibacterial Properties“. Australian Journal of Chemistry 73, Nr. 3 (2020): 151. http://dx.doi.org/10.1071/ch19359.

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The encapsulation of drugs in nanoparticles serves as an effective way to modify pharmacokinetics and therapeutic efficacy. Nanoparticles comprised of poly(d,l-lactide-co-glycolide) (PLGA) are well suited for this purpose; they are accessible using multiple synthesis methods, are highly biocompatible and biodegradable, and possess desirable drug release properties. In the present study, we have explored the effects of various formulation parameters on the physical properties of PLGA nanoparticles synthesised using a microfluidic assisted nanoprecipitation method and loaded with a model drug. PLGA nanoparticles, with diameters ranging from 165–364nm, were produced using three alternate stabilisers; poly(vinyl alcohol) (PVA), d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS), and didodecyldimethylammonium bromide (DMAB). Three additional formulations used PVA in addition to 20wt-% 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP), 1,2-di-O-octadecenyl-3-trimethylammonium propane (DOTMA), and oleic acid. Spectrophotometric analysis demonstrated that the use of PVA increased the loading efficiency over that of TPGS and DMAB formulations, while the inclusion of oleic acid in the PVA formulation resulted in a further 3-fold increase in loading efficiency. Invitro release studies demonstrate that the inclusion of lipid additives significantly alters release kinetics; release was most rapid and complete in the formulation containing oleic acid, while the addition of DOTAP and DOTMA significantly reduced release rates. Finally, the antimicrobial activity of each formulation was tested against Staphylococcus aureus and Bacillus cereus, with minimum inhibitory concentrations nearing or exceeding that of free rifampicin.

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Garda, Zoltán, Tamara Kócs, István Bányai, José A. Martins, Ferenc Krisztián Kálmán, Imre Tóth, Carlos F. G. C. Geraldes und Gyula Tircsó. „Complexes of Bifunctional DO3A-N-(α-amino)propinate Ligands with Mg(II), Ca(II), Cu(II), Zn(II), and Lanthanide(III) Ions: Thermodynamic Stability, Formation and Dissociation Kinetics, and Solution Dynamic NMR Studies“. Molecules 26, Nr. 16 (16.08.2021): 4956. http://dx.doi.org/10.3390/molecules26164956.

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The thermodynamic, kinetic, and structural properties of Ln3+ complexes with the bifunctional DO3A-ACE4− ligand and its amide derivative DO3A-BACE4− (modelling the case where DO3A-ACE4− ligand binds to vector molecules) have been studied in order to confirm the usefulness of the corresponding Gd3+ complexes as relaxation labels of targeted MRI contrast agents. The stability constants of the Mg2+ and Ca2+ complexes of DO3A-ACE4− and DO3A-BACE4− complexes are lower than for DOTA4− and DO3A3−, while the Zn2+ and Cu2+ complexes have similar and higher stability than for DOTA4− and DO3A3− complexes. The stability constants of the Ln(DO3A-BACE)− complexes increase from Ce3+ to Gd3+ but remain practically constant for the late Ln3+ ions (represented by Yb3+). The stability constants of the Ln(DO3A-ACE)4− and Ln(DO3A-BACE)4− complexes are several orders of magnitude lower than those of the corresponding DOTA4− and DO3A3− complexes. The formation rate of Eu(DO3A-ACE)− is one order of magnitude slower than for Eu(DOTA)−, due to the presence of the protonated amine group, which destabilizes the protonated intermediate complex. This protonated group causes the Ln(DO3A-ACE)− complexes to dissociate several orders of magnitude faster than Ln(DOTA)− and its absence in the Ln(DO3A-BACE)− complexes results in inertness similar to Ln(DOTA)− (as judged by the rate constants of acid assisted dissociation). The 1H NMR spectra of the diamagnetic Y(DO3A-ACE)− and Y(DO3A-BACE)− reflect the slow dynamics at low temperatures of the intramolecular isomerization process between the SA pair of enantiomers, R-Λ(λλλλ) and S-Δ(δδδδ). The conformation of the Cα-substituted pendant arm is different in the two complexes, where the bulky substituent is further away from the macrocyclic ring in Y(DO3A-BACE)− than the amino group in Y(DO3A-ACE)− to minimize steric hindrance. The temperature dependence of the spectra reflects slower ring motions than pendant arms rearrangements in both complexes. Although losing some thermodynamic stability relative to Gd(DOTA)−, Gd(DO3A-BACE)− is still quite inert, indicating the usefulness of the bifunctional DO3A-ACE4− in the design of GBCAs and Ln3+-based tags for protein structural NMR analysis.

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Guerra, Cecília, Patrícia Sá, Rebeca Teja und Jaime Ribeiro. „A Permeabilidade entre as Fronteiras das Ciências Sociais e Humanas: A interação de conhecimentos na investigação qualitativa“. Fronteiras: Journal of Social, Technological and Environmental Science 6, Nr. 4 (01.01.2018): 11. http://dx.doi.org/10.21664/2238-8869.2017v6i4.p11-17.

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A abordagem qualitativa nas ciências sociais e humanas enriquece a perspetiva daquele procura saber mais, ir mais fundo, ao amago dos comportamentos e da sua etiologia, na implexa rede que é o Homem e as suas relações. Estes campos da Ciência dotam, ou procuram dotar, o investigador com os instrumentos e do conhecimento para anatomizar o ser social, o Homem, o indivíduo. Não é descurado afirmar que não se pode investigar adequadamente o ser humano, sem a utilização de uma perspetiva multidisciplinar e/ou interdisciplinar, intrínseca às ciências sociais e humanas, bem como às ciências da natureza e da saúde (Chizotti 2006).

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del Olmo-García, Maria Isabel, Maria Angustias Muros, Martín López-de-la-Torre, Marc Agudelo, Pilar Bello, Jose M. Soriano und Juan-Francisco Merino-Torres. „Prevention and Management of Hormonal Crisis during Theragnosis with LU-DOTA-TATE in Neuroendocrine Tumors. A Systematic Review and Approach Proposal“. Journal of Clinical Medicine 9, Nr. 7 (12.07.2020): 2203. http://dx.doi.org/10.3390/jcm9072203.

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Neuroendocrine tumors (NETs) frequently overexpress somatostatin receptors (SSTR) on their cell surface. The first-line pharmacological treatment for inoperable metastatic functioning well-differentiated NETs are somatostatin analogs. On second line, Lu-DOTA-TATE (177Lu-DOTA0 Tyr 3 octreotate) has shown stabilization of the disease and an increase in progression free survival, as well as effectiveness in controlling symptoms and increasing quality of life. The management of functional NETs before and during LU-DOTA-TATE treatment is specially challenging, as several complications such as severe carcinoid and catecholamine crisis have been described. The aim of this review is to establish practical guidance for the management and prevention of the most common hormonal crises during radionuclide treatment with Lu-DOTA-TATE: carcinoid syndrome (CS) and catecholamine hypersecretion, as well as to provide a brief commentary on other infrequent metabolic complications. To establish a practical approach, a systematic review was performed. This systematic review was developed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and conducted using MEDLINE (accessed from PubMed), Google Scholar and ClinicalTrials.gov. Literature searches found 449 citations, and finally nine were considered for this systematic review.

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Kovács, Attila, und Zoltán Varga. „Metal–ligand interactions in complexes of cyclen-based ligands with Bi and Ac“. Structural Chemistry 32, Nr. 5 (18.08.2021): 1719–31. http://dx.doi.org/10.1007/s11224-021-01816-9.

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AbstractThe structural and bonding properties of Bi and Ac complexes with cyclen-based chelating ligands have been studied using relativistic DFT calculations in conjunction with TZ2P all-electron basis sets. Besides the parent cyclen ligand, the study has covered its extensions with pyridine-type (Lpy), carboxylate (DOTA, DOTPA), picolinate (MeDO2PA) and phosphonate (DOTMP) pendant arms. The effect of the cyclen ring size has been probed by increasing it from [12]aneN4 to [16]aneN4. Additional extensions in the DOTA complexes included the H2O ligand at the 9th coordination site as well as the p-SCN-Bn substituent (a popular linker to the targeting vector). The study focuses on the complex stability, the nature of bonding and the differences between Ac and Bi in the complexes. The metal–ligand interactions have been analysed by the Extended Transition State method combined with Natural Orbitals of Chemical Valence theory and Quantum Theory of Atoms in Molecules models.

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García Dávila, Rocío Elizabeth, Sergio Díaz Bello, Raúl Villanueva Rodríguez, René López León und Luis Valencia Vázquez. „Utilidad de la tomografía por emisión de positrones/tomografía computada (PET/CT) en pacientes con diagnóstico de meduloblastoma“. Revista de la Facultad de Medicina 63, Nr. 1 (10.01.2020): 34–41. http://dx.doi.org/10.22201/fm.24484865e.2020.63.1.06.

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"PET/CT (positron emission tomography/computed tomography, for its acronym in English) is a unique imaging method that provides in vivo evidence of both biochemical and physiological activities of the brain, spinal cord and tumors that involve these structures. Medulloblastoma is the most common malignant tumor of the central nervous system (CNS) in pediatric patients, so PET/CT plays an important role as it provides information on the grade and extent of the tumor as well as to determine the appropriate site for the biopsy, assessing the response to the treatment and the patient’s prognosis. There are different radiopharmaceuticals for the evaluation of central nervous system tumors, but 18F FDG (Fluor-2-fluoro-2-desoxy-D-glucose) and 68Ga-DOTA-NOC (68Ga-DOTA0-1NaI3-octreotide) have been studied to help us evaluate and follow up patients diagnosed with medulloblastoma. Medulloblastoma has an overexpression of glucose transporters, mainly type 1, and an overexpression of predominantly type 2 somatostatin receptors, which allows a high affinity for these radiopharmaceuticals. Key words: Medulloblastoma; positron emission tomography; PET/C; 18F-FDG; 68Ga-DOTA-NOC; brain tumor.

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Stępkowska, Agnieszka. „CHARAKTER ZAKAZU ALIENACJI NIERUCHOMOŚCI POSAGOWYCH W RZYMSKIM PRAWIE KLASYCZNYM“. Zeszyty Prawnicze 11, Nr. 1 (21.12.2016): 295. http://dx.doi.org/10.21697/zp.2011.11.1.16.

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LEGAL CHARACTER OF THE PROHIBITION AGAINST ALIENATION OF DOWRY IMMOVABLES IN THE CLASSICAL ROMAN LAWSummary The well known lex Iulia de fundo dotali prohibited alienation of a Italian land being part of a dowry without women’s consent. The very meaning of this prohibition attracted very much attention of the Roman law scholars in the 20th century. The problem was as follows: was the disposition in breach of the lex Julia null and void (absolute nullity), or was it only voidable by the woman (respective nullity) after the dissolution of her marriage. The later opinion seems to be dominating in 20th century writings on Roman law, since Pierre Noailles had advocated it in his book L’inaliénabilité dotale et la Novelle 61 (Grenoble, 1919). It was subsequently affirmated by such emminent authors like Fritz Pringsheim or Paul Koschaker and became ‘canonic’ oppinion among Roman law scholars. The problem in itself was alien to Romans knowing no difference between absoluteand respective nullity of a disposition, but it looks like, virtual position of Romanlaw in this respect, was not the most attractive to modern scholars. The present paper re-considers the issue taking slightly different departurepoint to that of Noailles and his followers. In the first instance, the category of leges – as regards sanctio of their prohibitory provisions – to which the lex Iulia de fundo dotali belongs is settled. Than the issue, who is entitled to vindicate the land alienated in breach of the lex Iulia, is analysed as well as possibility of convalidation of the invalid disposition. Finally it is considered, whether the statutory provision affected only real transfer of property or it frustrated already husband’s very ability to make a valid contract of sale. In effect, the argument of the present paper is as follows: alienation fundi dotalis without wife’s consent, was beyond any reasonable doubt null and void. Being still the owner of illegally alienated immovables, the husband was bound to vindicate them. For that very reason, he was not able to transfer free and unimpeded possession of the land to the unfortunate purchaser. Consequently, it was not only alienation of the land in dowry, which was null and void by virtue of the lex Iulia de fundo dotali, but also the very contract of it’s sale. Above findings require, the theory of “relative nullity” (i.e. voidability or rescindibility), as advocated by Noailles, Prinzheim and Koschaker, is to be rejected.

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Nussinov, Shmuel. „Yossef Dothan“. Physics Today 44, Nr. 7 (Juli 1991): 73–74. http://dx.doi.org/10.1063/1.2810186.

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Kenoyer, Aimee L., Yukang Lin, Johnnie J. Orozco, Ethan Balkin, Don Hamlin, Alexandra H. Hernandez, Chen Fang et al. „Pre-Targeted Radioimmunotherapy Employing a Recombinant Bispecific Antibody Using a Murine Xenograft Model of Human Leukemia“. Blood 124, Nr. 21 (06.12.2014): 3749. http://dx.doi.org/10.1182/blood.v124.21.3749.3749.

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Abstract Introduction: Acute Myeloid Leukemia (AML) has a high rate of relapse despite hematopoietic cell transplantation (HCT). Pre-targeted radioimmunotherapy (PRIT) prior to HCT offers a promising approach to reduce relapse for high-risk patients. PRIT studies with antibody-streptavidin (Ab-SAV) conjugates have shown promise, but may be limited by SAV immunogenicity. We have developed a recombinant anti-human CD45 bispecific Ab with picomolar affinity to radiolabeled DOTA chelates for targeting AML xenografts in a preclinical model. Methods: We engineered a bispecific Ab recognizing CD45 and DOTA-metal chelates. The light chain sequence from anti-human CD45 Ab (BC8) was cloned into a pFUSE vector along with a single-chain variable region developed to bind to DOTA chelates of multiple radionuclides. Ab was co-transfected into HEK 293 F cells with a pFUSE vector containing heavy chain sequence from Rituximab. Cultures were grown to extinction, and Ab purified via Protein A ion-exchange chromatography. Ab was characterized by SDS-PAGE, HPLC, and flow cytometry to determine specificity and integrity of material. Ab was tested for in vivo targeting in a xenograft model of human AML. Athymic mice bearing flank HEL tumors (30 to 100 µg) were injected with 280 µg bispecific Ab or 300 µg Ab-SAV. Twenty two hours later mice were treated with or without clearing agent (5 µg DOTAY-dextran for bispecific Ab and 50 µg NAGB for Ab-SAV groups). Two hours later mice were given Yttrium-90 (90Y)-DOTA-biotin. Blood was taken at time points over 22 hours post-injection for pharmacokinetic study; xenografts and normal tissues were taken 4, 24, and 48 hours after DOTA-biotin injection for gamma counts. Results: Bispecific Ab targeting CD45 bound to human AML cells in vitro with an increase in mean fluorescence intensity >2 logs compared to control. SDS-PAGE and HPLC demonstrated a construct of expected size. Blood clearance of 90Y-DOTA-biotin was assessed following injection of bispecific Ab with or without clearing agent and compared to mice that received BC8-SAV as the first-step reagent. Even without clearing agent, mice that had received bispecific Ab showed rapid blood clearance of 90Y-DOTA-biotin similar to that of Ab-SAV-injected mice that had received clearing agent, with 8.15 ± 0.56 % ID/g in the blood 5 minutes post-DOTA-biotin injection falling to 1.02 ± 0.62% ID/g within 4 hours and 0.40 ± 0.16 % ID/g at 20 hours. Mice that received BC8-SAV followed by clearing agent had 7.32 ± 2.0 % ID/g in the blood 5 minutes post-injection, falling to 1.13 ± 0.77 % within 4 hours and 0.73 ± 0.46 % at 20 hours. Mice receiving bispecific Ab followed by DOTAY-dextran clearing agent and 90Y-DOTA-biotin showed a rapid blood clearance with a radioactivity concentration of 8.07 ± 3.0% ID/g at 5 minutes and falling to 0.14 ± 0.03 % within 4 hours post-injection. In vivo targeting of the bispecific Ab was similar to Ab-SAV groups; within 4 hours 3.62 ± 0.91 % ID/g was detected in the tumor compared to 0.12 ± 0.05 % in the blood for mice receiving bispecific Ab, while Ab-SAV mice had a tumor value of 3.85 ± 2.5 % and blood was 1.17 ± 0.63 %. Uptake in non-target tissues was low at 4 hours post-injection compared to tumor, with liver and kidney values of 0.05 ± 0.014 % ID/g and 0.518 ± 0.09 % ID/g, respectively. Tumor retention remained steady at 24 and 48 hours with values of 4.13 ± 1.0% ID/g and 4.14 ± 2.47% ID/g respectively. Groups that received bispecific Ab as the first-step agent followed by clearing agent and then 90Y-DOTA-biotin showed slightly higher uptake in normal organs early on, but displayed higher uptake in target tissue. Tumor values at 4, 24, and 48 hours post-injection were 4.65 ± 2.4, 5.89 ± 4.2, and 3.95 ± 2.3 % ID/g, respectively. Conclusion: Recombinant bispecific Ab targeting both human CD45 and radiometal-labeled DOTA is promising as a novel therapeutic approach for AML prior to HCT. Bispecific Ab targets human AML cells in vitro and in vivo with favorable biodistribution showing specific uptake in tumors while normal organs displayed minimal uptake. Blood clearance of the bispecific Ab is rapid and comparable to that of Ab-SAV, even without the addition of a clearing agent. Future studies will assess therapeutic potential of this bispecific Ab PRIT approach in a murine model of AML. Funding Source Acknowledgment: Research reported in this publication was supported by the National Cancer Institute under award numbers R01CA109663, R01CA136639, and R01CA138720. Disclosures No relevant conflicts of interest to declare.

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Dissertationen zum Thema "Dotlak"

Havel, Jiří. „Hodnocení porezity u tlakově litých odlitků z Al slitin“. Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2012. http://www.nusl.cz/ntk/nusl-230266.

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The aim of this diploma thesis is to analyse the porosity of die - cast cast that were made of the alloy AISi9u3 in iron-foundry Skoda Car Mlada Boleslav. The analysis and the sample comparisons are based on my own measurements and are also connected with previous diploma thesis which deals with that issue and was drawn up at Technical University in Brno. All measurements were statistically tested.

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Lefner, Jiří. „Hodnocení mechanických a strukturních vlastností nového bloku“. Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2009. http://www.nusl.cz/ntk/nusl-228721.

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The purpose of this dilploma thesis is to evaluate mechanical and structural properties of two types casts of Al-alloy (components of the engine block) which were made by different technologies. Die casting with local squeeze casting and without local squeeze casting. First of them is used in lot manufacture of the current engine block. The aim of the foundry is to change the technology and start to produce new block by the die casting without local squeeze casting. The samples were taken from the both parts (lower and upper part) of the current and the new engine block which are made in foundry of Skoda Auto a.c. in Mladá Boleslav. Sets of mechanical and structural properties were selected, evaluated and tested by statistical programs. It was used fifty casts of the engine blocks for the experiment.

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Khamzin, Yersin. „Technologie vstřikování zkušebních těles z termoplastů“. Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2021. http://www.nusl.cz/ntk/nusl-444217.

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The diploma thesis focuses on the optimization of technological parameters of plastic injection molding and the study of the influence of technological parameters on the quality of molded test specimens’ type 1A. The quality of molded parts for 3 types of polypropylene (PP) with different melt flow rate (Mosten GB 002, Mosten GB 218, Mosten MA 230) and 1 type of polystyrene (PS) (Krasten PS GP 154) was evaluated in terms of dimensional stability and weight. The contribution of software for modeling the plastic injection molding process was evaluated in this work. SOLIDWORKS Plastics software was used to optimize technological parameters. The construction of the bodies, mold and cooling system was constructed, and test bodies were produced on the basis of parameters obtained from the simulation of the injection molding process. Their quality parameters were compared with a 3D model and for each of the studied materials the optimal technological parameters were selected in terms of quality and the degree of influence of individual injection parameters on the quality of moldings was evaluated. The accordance of the results of the theoretical simulation with the real experiment was proved and a computational module independent of the optimized quality parameters, generally suitable for optimizing the quality parameters of the injected parts, was developed.

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Lewis, W. Charles. „Selected ministry factors that may contribute to the interracial status of Dothan Community Church a case study /“. Online full text .pdf document, available to Fuller patrons only, 2000. http://www.tren.com.

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Svenblad, Hampus, und Josefin Bengtsson. „Ideation through visualization : – The use of Storyboard as a preparing tool“. Thesis, Mälardalens högskola, Akademin för innovation, design och teknik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-24270.

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Problem Ideation in group is used by many, often as a tool for creating new and innovative ways to solve problems and creating change. Groups may have difficulties to move from the phase of inspiration to the phase of ideation, if information and ideas aren’t defined in the team. The authors claim that this process can be helped by providing practical tools that are adapted and tested for the purpose. The reason is to foster concretization of volatile thoughts in form of inspiration and information. Purpose The study aims to investigate how Storyboard as a tool can be used to concretize thoughts and inspiration in a group before ideation. Method In order to collect empirical data the authors along with four other facilitators, conducted 24 DO TANK:s for the innovation contest Smart Lunch. The empirical data where then analyzed using theories related to the topic. To obtain further empirical information the authors conducted a open dialogue with the other facilitators. Conclusions The study shows that it’s possible to use Storyboard as a tool for specifying and collect a group’s thoughts before ideation. Furthermore the authors consider that the use of Storyboard enables a more efficient ideation as the groups becomes more focused when they’ve defined their thoughts.
Problemformulering Idégenerering i grupp används idag av många, ofta som ett verktyg för att kunna skapa nya och innovativa sätt för att lösa problem och skapa förändring. Det finns svårigheter för grupper att gå från det som författarna kallar inspirationsfasen vidare till idégenereringsfasen, då information och tankar fortfarande inte är fastställda. Författarna menar att denna process går att underlätta genom att tillföra konkreta verktyg anpassade och testade för idéutvecklingsprocessernas olika faser. Anledningen är att främja konkretisering av flyktiga och svårtolkade tankar i form av inspiration och information. Syfte Studiens syfte är att undersöka hur verktyget Storyboard, tidigare använt inom filmindustrin kan användas som konkretiseringsverktyg inför en idégenerering i en gruppkonstellation? Metod För att samla in empirisk data har författarna, tillsammans med fyra andra facilitatorer, genomfört 24 st. DO TANK:s för innovationstävlingen Smart Lunch. Detta empiriska material har sedan analyserats med hjälp av teorier kopplade till ämnet. För att få ytterligare empirisk information har författarna utfört en öppen dialogintervju med facilitatorerna. Slutsatser Studien visar att det med fördel går att använda verktyget Storyboard för att konkretisera och samla en grupps tankar inför en idégenrering. Vidare anser författarna att detta möjliggör en effektivisering av idégenrereringsprocessen då denna blir mer fokuserad när gruppen är enig.

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Cockerham, Catherine L. „Burial practice at Tell Dothan was Tomb 1 a "byt mrzḥ"? /“. Theological Research Exchange Network (TREN), 1995. http://www.tren.com.

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Bengtsson, Linda. „Spin-coatade dispersioner på glasytor : en studie av aggregationen mellan latex och DoTAB med AFM“. Thesis, Karlstads universitet, Fakulteten för teknik- och naturvetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-14568.

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Zhou, Chan Dante. „Reputación del streamer peruano de Dota 2: la perspectiva del jugador de Dota 2 peruano“. Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2020. http://hdl.handle.net/10757/654794.

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La industria gamer ha llevado a la posibilidad de subsistir económicamente del streaming. Dado que los streamers generan ingresos en relación con su audiencia, mientras mayor sea esta y esté más conectada con ella mayor probabilidad habrá de que genere mayores ingresos. Por ende, surge un nuevo modelo de negocio que requiere de una gestión reputacional para construir esta audiencia. Para ello, se necesita un primer análisis del contexto peruano desde la percepción que mantienen los jugadores de Dota 2 peruanos frente a los streamers peruanos de Dota 2. Por ello, este trabajo utiliza el paradigma naturalista/interpretativo que estudia al público en su contexto natural, es decir los gamers y el Dota 2. El diseño para este sería fenomenológico pues se busca entender la percepción (reputación) del streamer peruano desde el punto de vista de los jugadores de Dota 2 en general. Finalmente, se usa un enfoque cualitativo para obtener las opiniones de los usuarios que juegan Dota 2 sobre los streamers peruanos, con el uso de entrevistas semiestructuradas para alinearlas en los 3 aspectos para medir reputación: sólida dimensión axiológica, comportamiento comprometido y calidad de servicio.
The gaming industry has led to the possibility of economically subsisting on streaming. Since streamers generate income in relation to their audience, the larger their audience and the more connected they are, the greater probability of generating more income will exist. Therefore, a new business model emerges that requires reputational management to build this audience. To do this, a first analysis of the Peruvian context is needed from the perception that Peruvian Dota 2 players maintain compared to Peruvian Dota 2 streamers. That’s why, this work uses the naturalistic paradigm /interpretive that studies the public in its natural context, that is, the gamers in their gameplay and the design for this would be phenomenological because it seeks to understand the perception (reputation) of the Peruvian streamer from the point of view of Dota 2 players in general. Finally, a qualitative approach is used to obtain the opinions of the users who play Dota 2 on the Peruvian streamers, with the use of semi-structured interviews to align them in the 3 aspects to measure reputation: solid axiological dimension, committed behavior and quality of service.
Trabajo de investigación

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VARGAS, GARCIA ERNESTO 502720, und GARCIA ERNESTO VARGAS. „Dotar a la acción penal privada de un procedimiento que haga eficaz la impartición de justicia penal“. Tesis de doctorado, Universidad Autónoma del Estado de México, 2016. http://hdl.handle.net/20.500.11799/58242.

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En el capítulo primero se desarrolló con apego al método histórico, el cual permitió conocer el trato que se le dio a la víctima u ofendido en el procedimiento penal, en el siglo V (procedimiento no jurisdiccional). La investigación utiliza el método analítico, con el cual se examina el papel de la víctima sancionando al infractor con la autorización de su comunidad, la cual legitimaba su actuar, debido a que la víctima era considerada parte central en el sistema de justicia penal, esta forma de impartir justicia es el antecedente de la acción penal privada, tema en estudio, por esta razón, se retrotrae la investigación a la etapa histórica, lo que justifica que la justicia en manos de la víctima no es una novedad, es el origen del derecho penal.

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Terp, Megan Cavanaugh. „Improved Nanoparticle Preparation and Delivery Technology for DOTAP and Oligonucleotide Based Lipoplexes“. The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1338301430.

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Bücher zum Thema "Dotlak"

Anders, Bodelsen. Dotla: Roman = Borte borte : roman. Moskva: Raduga, 1985.

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Bodelsen, Anders. Dotla: Roman = Borte borte : roman. Moskva: Raduga, 1985.

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Komel, Mirt. Pokus nekega dotika. Ljubljana: Fakulteta za družbene vede, Založba FDV, 2008.

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Yamanouchi, Reiko. Jitsuzaishita Ina Ōkoku. Ibaraki-shi: Fujita Tomoji, 1996.

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Tronkar, Francka. Dotik mavrice. Kranj: Lotos, 1999.

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Komel, Mirt. Pianistov dotik. Novo mesto: Goga, 2015.

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Donev, Kamen. Vsichko dotuk. Veliko Tŭrnovo: Abagar, 2006.

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Jensterle, Miha. Na oni strani dotika. [S.l.]: M. Jensterle, 1999.

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Jensterle, Miha. Na oni strani dotika. [Ljubljana?]: M. Jensterle, 1999.

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Bedirxan, Celadet Ali. Were dotmam: Şiîrên Hawarê. Beyoğlu, İstanbul: Avesta, 1998.

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Buchteile zum Thema "Dotlak"

Zondergeld, Rein A. „Vondel, Joost van den: Joseph in Dothan“. In Kindlers Literatur Lexikon (KLL), 1–2. Stuttgart: J.B. Metzler, 2020. http://dx.doi.org/10.1007/978-3-476-05728-0_20478-1.

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Zuo, Long, Shuo Xiong und Hiroyuki Iida. „An Analysis of DOTA2 Using Game Refinement Measure“. In Entertainment Computing – ICEC 2017, 270–76. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-66715-7_29.

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Hirsch-Lerner, Danielle, Nicolaas J. Zuidam und Yechezkel Barenholz. „Physicochemical Characterization of DOTAP-Containing Lipoplexes by Fluorescent Probes: Relevance to Lipofection“. In Targeting of Drugs 6, 169–83. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-1-4899-0127-9_16.

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Falsini, Sara, und Sandra Ristori. „Lipoplexes from Non-viral Cationic Vectors: DOTAP-DOPE Liposomes and Gemini Micelles“. In Methods in Molecular Biology, 33–43. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3718-9_3.

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Sauer, Annika. „Crowdfunding und der Contributed Prize Pool in Dota 2“. In eSport, Netzwerkeffekte und Lindahl-Preise, 71–80. Wiesbaden: Springer Fachmedien Wiesbaden, 2019. http://dx.doi.org/10.1007/978-3-658-26210-5_6.

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Cunha, José C., Pedro Medeiros, João Lourenço, Vitor Duarte, João Vieira, Bruno Moscão, Daniel Pereira und Rui Vaz. „The DOTPAR project: Towards a framework supporting domain oriented tools for parallel and distributed processing“. In High-Performance Computing and Networking, 952–54. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/bfb0037241.

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Eidherr, Harald, Friedrich Girschele, Markus Mitterhauser und Wolfgang Wadsak. „Synthesis of [68Ga]Gallium Dota-(Tyr3)-Octreotide Acetate ([68Ga]-Dotatoc)“. In Radiochemical Syntheses, 321–34. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118140345.ch32.

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Ambrosini, Valentina, und Stefano Fanti. „68Ga-DOTA PET-CT in Treatment Response Evaluation: Neuroendocrine Tumours“. In Atlas of Clinical PET-CT in Treatment Response Evaluation in Oncology, 453–70. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-68858-5_27.

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Zairil Aznin, Mohammad Zaki Azim, Norizan Mat Diah und Nur Atiqah Sia Abdullah. „Expert System for Dota 2 Character Selection Using Rule-Based Technique“. In Advances in Visual Informatics, 318–26. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-34032-2_29.

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Smith, Robert J., und Malcolm I. Heywood. „Evolving a Dota 2 Hero Bot with a Probabilistic Shared Memory Model“. In Genetic Programming Theory and Practice XVII, 345–66. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-39958-0_17.

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Konferenzberichte zum Thema "Dotlak"

Pesquera, Alberto, Raul Morales, Rafael Pastor, Salvador Ros, Roberto Hernandez, Elio Sancristobal und Manuel Castro. „dotLAB: Integrating remote labs in dotLRN“. In 2011 IEEE Global Engineering Education Conference (EDUCON). IEEE, 2011. http://dx.doi.org/10.1109/educon.2011.5773123.

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Jensvold, Lars. „Dota 2 teaser“. In ACM SIGGRAPH 2012 Computer Animation Festival. New York, New York, USA: ACM Press, 2012. http://dx.doi.org/10.1145/2341836.2341848.

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Wang, Nanzhi, Lin Li, Linlong Xiao, Guocai Yang und Yue Zhou. „Outcome prediction of DOTA2 using machine learning methods“. In ICMAI '18: 2018 International Conference on Mathematics and Artificial Intelligence. New York, NY, USA: ACM, 2018. http://dx.doi.org/10.1145/3208788.3208800.

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Cavalli, Ana, Stephane Maag und Gerardo Morales. „Regression and Performance Testing of an e-Learning Web Application: dotLRN“. In 2007 Third International IEEE Conference on Signal-Image Technologies and Internet-Based System SITIS. IEEE, 2007. http://dx.doi.org/10.1109/sitis.2007.129.

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Wang, Kaixiang, und Wenqian Shang. „Outcome prediction of DOTA2 based on Naïve Bayes classifier“. In 2017 IEEE/ACIS 16th International Conference on Computer and Information Science (ICIS). IEEE, 2017. http://dx.doi.org/10.1109/icis.2017.7960061.

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Hereyah, Y., und S. Darmawan. „Construction of Emotional Intelligence Gamers in Win Game DOTA2“. In Proceedings of the First Brawijaya International Conference on Social and Political Sciences, BSPACE, 26-28 November, 2019, Malang, East Java, Indonesia. EAI, 2020. http://dx.doi.org/10.4108/eai.26-11-2019.2295210.

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Huerva, David, Jeimy Velez, Silvia Baldiris, Ramón Fabregat und David Merida. „Adaption of Courses and Learning Environment to the User Context in dotLRN“. In 2008 International Conference on Computational Intelligence for Modelling Control & Automation. IEEE, 2008. http://dx.doi.org/10.1109/cimca.2008.140.

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Gomez, Fabinton Sotelo, Armando Ordonez und Mario Fernando Solarte. „Evaluation of the reference framework for integration of web resources in DotLRN“. In 2015 10th Computing Colombian Conference (10CCC). IEEE, 2015. http://dx.doi.org/10.1109/columbiancc.2015.7333463.

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Hänscheid, H., P. Hartrampf, A. Schirbel, AK Buck und C. Lapa. „Lu-177-DOTA-EBTATE vs. Lu-177-DOTA-TOC - ein intraindividueller Vergleich der Biokinetik“. In NuklearMedizin 2020. © Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0040-1708253.

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Ryan, Brandon, und Chandana Mitra. „ANALYSIS OF FUTURE URBAN GROWTH OF THE COLUMBUS-DOTHAN-PANAMA CITY URBAN CLIMATE ARCHIPELAGO“. In Southeastern Section-70th Annual Meeting-2021. Geological Society of America, 2021. http://dx.doi.org/10.1130/abs/2021se-362316.

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Berichte der Organisationen zum Thema "Dotlak"

Ketusky, E. T., C. Brandjes und T. J. Benoit. Test report dot7A type A liquid packaging. Office of Scientific and Technical Information (OSTI), September 2017. http://dx.doi.org/10.2172/1392912.

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Mortimer, Joanne. 64Cu-DOTA-Trastuzumab PET Imaging in Women with HER2-Overexpressing Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, Oktober 2013. http://dx.doi.org/10.21236/ada598708.

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Webber, Benjamin. Investigation of the Structure and Dynamics of Regioisomeric Eu³⁺ and Gd³⁺ Chelates of NB-DOTMA: Implications for MRI Contrast Agent Design. Portland State University Library, Januar 2000. http://dx.doi.org/10.15760/etd.1497.

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Espinosa, Carlos. Provisión de agua potable a las poblaciones sin acceso a redes durante la emergencia por COVID-19: Experiencias en Latinoamérica y el Caribe. Herausgegeben von Tania Páez und Cesarina Quintana. Inter-American Development Bank, Januar 2021. http://dx.doi.org/10.18235/0003007.

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El documento contiene el relevamiento de las soluciones implementadas por treinta entidades de servicios de agua potable y saneamiento de once países de LAC, respecto a soluciones implementadas para dotar de agua potable a poblaciones vulnerables sin acceso a redes y de prácticas para recolección y desecho de aguas residuales domésticas durante la pandemia por COVID-19. El relevamiento además de incluir las soluciones implementadas, relevó las características de la solución, características geográficas de actuación del prestador, tamaño de la población atendida, y los desafíos y lecciones aprendidas que los diferentes prestadores indicaron sobre la implementación de soluciones de provisión del servicio de agua potable a poblaciones vulnerables.

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