Dissertationen zum Thema „Dopamine type I receptor“
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Hatcher-Solis, Candice N. „PHARMACOLOGICAL IMPLICATIONS OF ADENOSINE 2A RECEPTOR- DOPAMINE TYPE 2 RECEPTOR HETEROMERIZATION“. VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4458.
Der volle Inhalt der QuelleZANINOVICH, OREL ANTHONY. „THE CLONING OF AN INDR-TYPE DOPAMINE RECEPTOR IN MANDUCA SEXTA“. Thesis, The University of Arizona, 2008. http://hdl.handle.net/10150/192256.
Der volle Inhalt der QuelleMann, Miranda Jane. „A neuropsychological investigation of dopamine receptor 4 differences among attention deficit hyperactivity disorder-combined type and control children /“. Digital version accessible at:, 2000. http://wwwlib.umi.com/cr/utexas/main.
Der volle Inhalt der QuelleGorji, Hassan. „Role of adenylyl cyclase type 5 in the regulation of the dopamine D3 receptor phosphorylation“. Thesis, University of Ottawa (Canada), 2006. http://hdl.handle.net/10393/27364.
Der volle Inhalt der QuelleMaier, Annette Louise. „Comparative regional ontogeny of dopamine D₁ receptor binding and mRNA expression in pre- and postnatal rat brain /“. Zürich, 1994. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=10902.
Der volle Inhalt der QuelleEtchepare, Laetitia. „Role of glutamate N-Methyl-D-Aspartate receptor surface trafficking in the firing pattern of midbrain dopaminergic neurons“. Thesis, Bordeaux, 2017. http://www.theses.fr/2017BORD0849/document.
Der volle Inhalt der QuelleMidbrain dopaminergic (DA) neurons play several key functions in the brain such as the processing of salient information but are also associated with the emergence of pathologies including Parkinson’s disease and drug addiction. Because these processes have in common to modify the firing activity of midbrain DA neurons, it is of crucial importance to understand the mechanisms underlying this activity. Among the various ions channels and receptors involved in the generation of the firing activity of midbrain DA neurons, glutamate N-methyl-D-aspartate receptors (NMDAR) and calciumdependent potassium SK channels strongly modulate the firing pattern and functionally interact in several neuronal types including DA neurons. However, the mechanisms by which they regulate the firing pattern are poorly understood. Since the functional coupling between NMDAR and SK channels depends on their relative membrane distribution, we hypothesized that the lateral diffusion of NMDAR, which regulates the surface localization of the receptor, could play a role in the firing pattern of midbrain DA neurons through the modulation of SK channel function. We showed first that membrane NMDAR was highly mobile in cultured DA neurons. Alteration of its surface trafficking by a crosslink with NMDAR antibodies profoundly modified the regularity of the firing pattern of DA neurons in midbrain slices, whereas pharmacological blockade of NMDAR did not affect it. Furthermore, a SK channel blocker, which induces a similar change in the firing regularity in control conditions, was less effective when NMDAR surface trafficking was altered. Taken together, these results demonstrate that NMDAR surface dynamics modulate the firing pattern of midbrain DA neurons by regulating SK channel function
Roberts-Crowley, Mandy L. „Modulation of Cav1.3 L-Type Calcium Channels by Arachidonic Acid and Muscarinic M1 Receptors: A Dissertation“. eScholarship@UMMS, 2007. https://escholarship.umassmed.edu/gsbs_diss/348.
Der volle Inhalt der QuelleLucas, Guillaume. „Etude in vivo des modalités d'intervention de la sérotonine et des récepteurs sérotoninergiques de type 5-HT/2A/2C, 5-HT3 et 5-HT4 dans le contrôle de la transmission dopaminergique nigro-striée et mésoaccumbale chez le rat“. Bordeaux 2, 1999. http://www.theses.fr/1999BOR28692.
Der volle Inhalt der QuelleHegron, Alan. „Implication des récepteurs de la mélatonine dans les troubles neurologiques et le diabète de type 2 et identification de régions clés du récepteur MT1 responsables de sa sélectivité fonctionnelle“. Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS555/document.
Der volle Inhalt der QuelleMelatonin is a neurohormone mainly released from the pineal gland in a circadian manner acting through two G protein-coupled receptors (GPCRs) called MT1 and MT2. Melatonin regulates many important physiological functions. Regulation of dopamine (DA) and glucose levels are two of them but how they do this is not clear.Extracellular DA levels are mainly regulated by its transporter (DAT) which mediates DA re-uptake into presynaptic nerve termini to prevent DA receptor hyperactivation in the presynaptic cleft. Consequently, we verified the role of DAT in the regulation of the DA system by melatonin. We showed that MT1 and MT2, by interacting with the immature non-glycosylated form of DAT retain DAT in the endoplasmic reticulum thus regulating DAT cell surface expression and DA reuptake. Consistently, mice with targeted deletion of MT1 and MT2 show markedly enhanced DA uptake in striatal synaptosomes and decreased amphetamine-induced locomotor activity. Collectively, we revealed here a molecular link between the melatonin and DA systems, which is based on the formation of a molecular complex between melatonin receptors and DAT.To better understand the role of melatonin on the regulation of glucose levels, we studied the involvement of genetic variants of MT2 in the development of type 2 diabetes (T2D). Previous studies showed that natural loss-of-function variants of MT2 associate with T2D risk. To determine more precisely the defective properties linked to T2D risk we monitored spontaneous and melatonin-induced activation of different signaling pathways by 40 MT2 variants. We show that defects in melatonin-induced Gαi and Gαz activation and spontaneous βarrestin-2 recruitment are most significantly associated to T2D risk. Experimental results correlated well with those predicted by evolutionary lineage analysis. This work will help to propose personalized treatments for MT2 variant carriers to recover their defective responses.Sequencing of 9393 individuals resulted in the identification of 32 natural MT1 variants. MT1 wild-type and variants were functionally characterized in bioluminescence resonance energy transfer (BRET) assays. We showed that MT1 activates Gαi/o, Gα12 and Gα15 proteins and recruits βarrestin-2. Analyzes of results by non-linear matrix factorization revealed the existence of 5 clusters characterized by different signaling profiles. Computational homology modeling of the 3D model of MT1 helped to determine the impact of each variant on receptor activation and interaction with G proteins and βarrestin-2. Collectively, our data illustrate that natural variants are powerful tools to understand the molecular basis of GPCR function. Overall, this work contributes to our understanding of the function of melatonin receptors and highlights their importance in the regulation of the DA system and glucose homeostasis. Our results will open new, personalized therapeutic options for patient suffering from a defective DA system or T2D
Thirtamara, Rajamani Keerthi Krishnan. „Animal Models of Drug Addiction and Autism Spectrum Disorders“. The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1386011455.
Der volle Inhalt der QuelleDomingo, Rodriguez Laura 1992. „Neurobiological mechanisms involved in the loss of control over food intake“. Doctoral thesis, Universitat Pompeu Fabra, 2020. http://hdl.handle.net/10803/668410.
Der volle Inhalt der QuelleEl fàcil accés a aliments altament saborosos és un factor important que contribueix a la ingesta compulsiva i al desenvolupament de l’addicció al menjar. Aquest trastorn està molt vinculat a l’obesitat i al trastorn per afartament. El concepte d’addicció al menjar és controvertit, però l’aparició d’una eina diagnòstica valida, el Yale food addiction scale (YFAS 2.0), ha sigut àmpliament acceptada. Tot i això, la naturalesa complexa i multifactorial d’aquest trastorn i la desconeguda correlació neurobiològica expliquen la manca actual de tractaments efectius. En aquesta tesi, hem utilitzat un model d’addicció al menjar en ratolins per descobrir el paper crucial de les vies cortico‐estriatals glutamatergiques modulades pels sistemes endocannabinoid i dopaminèrgic com a mecanisme clau per a la pèrdua del control inhibitori en la cerca d’aliments saborosos. Aquest resultat, amb el suport d’estudis electrofisiològics, seqüenciació d’ARN i d’ADN de tot el genoma i tècniques de “chemogenetics” ens donen una comprensió del trastorn a nivell genètic, epigenètic, cel·lular, de circuit i de comportament. Aquesta tesi revela un nou mecanisme neurobiològic subjacent a la resiliència i a la vulnerabilitat a desenvolupar addicció al menjar. S’espera que obri noves vies eficients d’intervenció per combatre el comportament d’ingesta compulsiva i altres trastorns relacionats.
Benac, Nathan. „Molecular mechanisms underlying the surface organization of the NMDA receptors during development“. Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0185.
Der volle Inhalt der QuelleUnderstanding how neurons develop to form the organized pattern of synaptic connections remains a central question in neuroscience. The vast majority of excitatory synapses are formed early in development during a synaptogenesis window. N-methyl-D-aspartate receptors (NMDAR) have long been a strong candidate to drive synaptogenesis as both in vivo and in vitro data show a key role for NMDARs during that phase. Furthermore, the facts that NMDARs are found in the developmentally immature “silent” synapses and among the first receptors to accumulate at the site of nascent synapses together lead to the assumption that NMDAR’s clustering is a nucleation point. Yet, the mechanisms underpinning the early clustering of NMDARs into synaptogenic assemblies remain enigmatic. Evidences that NMDARs can directly interact with other surface proteins, including receptors, has promoted the possibility that surface protein-protein interaction (PPI) represents a potent way to cluster receptors. Using a combination of live imaging and super-resolution microscopy, we observed that the interaction between D1R-GluN1-NMDARs were promoted in immature neurons, during the synaptogenesis phase. We showed that the D1R-GluN1-NMDAR interaction directly shapes the organization of NMDARs, allowing their functional clustering and synaptogenesis. Indeed, preventing the interaction in immature neurons, and not in mature neurons, altered the formation of excitatory post-synapses. We then focused on the intracellular and extracellular regulatory mechanisms of the interaction. We demonstrated a role of metabotropic glutamate receptors (mGluR) and casein kinase 1 (CK1) in promoting the interaction between D1Rs and GluN1-NMDARs. On the other hand, both the fact that the hyaluronic acid (HA), one of the main components of the extracellular matrix (ECM), is enriched early in the immature brain and regulates the surface diffusion of macromolecules opens the hypothesis that the ECM regulates the ability of NMDARs to interact with other surface macromolecules, including D1R. Yet, classical approaches have mainly focused on degrading the ECM. Herein, we aimed at increasing the ECM content in HA by over-expressing both the wild-type form of the rat hyaluronan synthase 2 (HAS2) or one bearing the two point-mutations present in the naked mole rat (NMR; N178S and N301S) which produces very high molecular weight HA (vHMW-HA). We observed that increasing the matrix impaired the development of the neuron and modified both the surface organization and trafficking of NMDARs. These findings validate our strategy, and open new paths for investigating the role of the ECM on neuronal development
Sugamori, Kim S. „The dopamine D1C receptor, expansion and origin of the dopamine D1 receptor family“. Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0001/NQ41320.pdf.
Der volle Inhalt der QuelleTorvinen, Maria. „Adenosine receptor/dopamine receptor interactions : molecular and biochemical aspects /“. Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-298-1/.
Der volle Inhalt der QuelleMiddleton, Lisa Sue. „Nicotine receptor modulation of dopamine transporters“. Lexington, Ky. : [University of Kentucky Libraries], 2005. http://lib.uky.edu/ETD/ukyphsc2006d00383/Middleton.pdf.
Der volle Inhalt der QuelleTitle from document title page (viewed on March 2, 2006). Document formatted into pages; contains vii, 264 p. : ill. Includes abstract and vita. Includes bibliographical references (p. 196-260).
Middleton, Lisa Sue. „NICOTINIC RECEPTOR MODULATION OF DOPAMINE TRANSPORTERS“. UKnowledge, 2006. http://uknowledge.uky.edu/gradschool_diss/412.
Der volle Inhalt der QuelleGenn, Rachel F. „Dopamine receptor subtypes and ingestive behaviour“. Thesis, Durham University, 1999. http://etheses.dur.ac.uk/4303/.
Der volle Inhalt der QuelleRimondini-Giorgini, Roberto. „Behavioural and biochemical pharmacology of adenosine/dopamine receptor/receptor interaction /“. Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3617-X/.
Der volle Inhalt der QuelleKim, Douglas S. „Dopamine and adenosine receptor function in adult and developing dopamine-deficient mice /“. Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/5063.
Der volle Inhalt der QuelleKnapp, Mark. „Development of dopamine receptor-expressing adenoviral vectors“. Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0001/MQ28801.pdf.
Der volle Inhalt der QuelleD'Souza, Ursula M. „Structure of the Dâ†2 dopamine receptor“. Thesis, University of Kent, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259680.
Der volle Inhalt der QuelleSalmi, Peter. „Clozapine as a dopamine D1 receptor agonist /“. Stockolm : Universitet Stockholms, 1998. http://catalogue.bnf.fr/ark:/12148/cb401175060.
Der volle Inhalt der QuelleSatchell, Rupert. „Signalling and regulation of the D1 dopamine receptor“. Thesis, University of Leicester, 2013. http://hdl.handle.net/2381/38068.
Der volle Inhalt der QuelleOldenhof, John. „SH3 binding domains in the dopamine D4 receptor“. Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0017/NQ45764.pdf.
Der volle Inhalt der Quelle謝志恒 und Chi-hang Tse. „Molecular cloning of the goldfish dopamine D2 receptor“. Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B42128511.
Der volle Inhalt der QuelleTse, Chi-hang. „Molecular cloning of the goldfish dopamine D2 receptor“. Click to view the E-thesis via HKUTO, 1998. http://sunzi.lib.hku.hk/hkuto/record/B42128511.
Der volle Inhalt der QuelleKarper, Patrick Eugene. „Role of the Dopamine D₁-like receptor in amphetamine-induced behavioral sensitization: A study using Dopamine D₁A-receptor deficient mice“. CSUSB ScholarWorks, 2000. https://scholarworks.lib.csusb.edu/etd-project/1682.
Der volle Inhalt der QuelleSheppard, Ashley Brianna. „Sex Differences in Nicotine-Conditioned Hyperactivity in a Model of Dopamine D2 Receptor Priming: Roles of Dopamine D2 and D3 Receptor Subtypes“. Digital Commons @ East Tennessee State University, 2008. https://dc.etsu.edu/etd/1978.
Der volle Inhalt der QuelleKotowski, Sarah. „Regulation of dopamine signaling by D1 receptor membrane trafficking“. Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3390053.
Der volle Inhalt der QuelleRay, Avi Andrew. „SH3 binding domains in the dopamine D¦3 receptor“. Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0018/MQ45843.pdf.
Der volle Inhalt der QuelleZawarynski, Paul. „Dopamine D2 receptor monomers, dimers and higher order oligomers“. Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0025/MQ40852.pdf.
Der volle Inhalt der QuelleTerasmaa, Anton. „Dopamine D2 receptor G protein coupling and its regulation /“. Stockholm, 2003. http://diss.kib.ki.se/2004/91-7349-788-6/.
Der volle Inhalt der QuellePesek, Erin Fae Newland M. Christopher. „The role of dopamine receptor subtypes in reinforced variability“. Auburn, Ala, 2008. http://repo.lib.auburn.edu/EtdRoot/2008/SUMMER/Psychology/Thesis/Pesek_Erin_41.pdf.
Der volle Inhalt der QuelleShaikh, Sanober. „Molecular genetic studies of dopamine receptor genes in schizophrenia“. Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243332.
Der volle Inhalt der QuelleKostrzewa, Richard M., John P. Kostrzewa, Russell W. Brown, Przemyslaw Nowak und University of Silesia Ryszard Brus Medical. „Dopamine Receptor Supersensitivity: Development, Mechanisms, Presentation, and Clinical Applicability“. Digital Commons @ East Tennessee State University, 2008. https://doi.org/10.1007/BF03033804.
Der volle Inhalt der QuelleMarcott, Pamela F. „Mechanisms of dopamine D2-receptor activation across the striatum“. Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1502719812531202.
Der volle Inhalt der QuelleGallagher, Edward Jude. „Targeted disruption of the neurotensin receptor gene“. Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241741.
Der volle Inhalt der QuelleXiang, Lianbin, Katalin Szebeni, Attila Szebeni, Violetta Klimek, Craig A. Stockmeier, Beata Karolewicz, John Kalbfleisch und Gregory A. Ordway. „Dopamine Receptor Gene Expression in Human Amygdaloid Nuclei: Elevated D4 Receptor mRNA in Major Depression“. Digital Commons @ East Tennessee State University, 2008. https://dc.etsu.edu/etsu-works/8608.
Der volle Inhalt der QuelleTumova, Katerina. „Uncovering the molecular interplays of dopamine D1-like receptor activation“. Thesis, University of Ottawa (Canada), 2003. http://hdl.handle.net/10393/26347.
Der volle Inhalt der QuelleKruse, Maria Sol. „Plasticity of the dopamine 1 receptor and its signaling pathway /“. Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-652-9/.
Der volle Inhalt der QuelleJohnson, Christopher Norbert. „The design and synthesis of subtype-selective dopamine receptor antagonists“. Thesis, University of Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266875.
Der volle Inhalt der QuelleCostanza, Rino Michelangelo. „Dopamine receptor subtype involvement in the behavioural effects of cocaine“. Thesis, University of Birmingham, 2000. http://etheses.bham.ac.uk//id/eprint/5890/.
Der volle Inhalt der QuelleKant, Andrew Charles Mailman Richard B. „Functional selectivity at the D1 dopamine receptor studies using SKF83959 /“. Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,2006.
Der volle Inhalt der QuelleTitle from electronic title page (viewed Feb. 17, 2009). "... in partial fulfillment of the requirements for the degree of Master of Science in the Curriculum in Toxicology." Discipline: Toxicology; Department/School: Medicine.
Stott, Lisa Alice. „Determination of agonist intrinsic efficacies at the dopamine D2 receptor“. Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/39305/.
Der volle Inhalt der QuelleEtter, Guillaume. „Role of retinoid X receptor gamma and dopamine receptor D2 in hippocampal and memory functions“. Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAJ055.
Der volle Inhalt der QuelleThe present thesis work is an attempt to understand the mechanisms of Rxrγ control of memory functions, as well as the potential involvement of dopaminergic signaling in these mecanisms. In this context, I focused my research on hippocampal functions at several distinct levels. The first part of my work (1) aimed at defining the hippocampal cell populations expressing Rxrγ using various histological techniques (immunohistochemistry, in situhybridization) in order to (2) study the electrophysiological functions of these cells using invitro patch-clamp.To identify the role of Rxrγ in the control of cell autonomous functions, as well as the consequences on the surrounding network, I have studied the effects of its loss of function in Rxrγ/mice.As the different subregions of the hippocampus are implicated indistinct aspects of learning and memory, and in particular the dentate gyrus being associated with pattern separation (Leutgeb et al., 2007), I have also tried to dissect the mnemonic processes that rely on Rxrγ activity by performing behavioral analyses of Rxrγ/mice. Considering the transcriptional activities of Rxrγ on Drd2, I have also (4) studied dopaminergic signaling in the hippocampus of wild type and Rxrγ null mutant mice. Finally, to demonstrate the neuroanatomical and homeostatic specificity of Rxrγ control on memory, I performed (5) specific inactivations of Rxrγ in hippocampi of conditional mutant mice that possessed floxed Rxrγ, using AAV vectors expressing recombinase Cre
Voicu, Cristian, und n/a. „Electrophysiological effects in the rat basal ganglia following systemic adenosine A2A receptor stimulation and dopamine D2 receptor blockade“. University of Otago. Department of Physiology, 2008. http://adt.otago.ac.nz./public/adt-NZDU20080811.155439.
Der volle Inhalt der QuelleAl-Ali, Asmaa M. H. „Understanding the role of dopamine D4 receptor regulation of mesolimbic dopamine function in a rat model of schizophrenia“. Thesis, University of Leicester, 2018. http://hdl.handle.net/2381/43047.
Der volle Inhalt der QuelleJaworski, Jason Noel. „Effect of dopamine D2/D3 receptor antagonist sulpiride on changes in mesolimbic dopamine produced by amphetamine and ethanol /“. Full text (PDF) from UMI/Dissertation Abstracts International, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3008360.
Der volle Inhalt der QuelleWorrall, S. „The purification of D2̲ dopamine receptors from bovine striatum“. Thesis, University of Nottingham, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377448.
Der volle Inhalt der QuelleFowler, Justin Corey Mailman Richard B. „Mechanisms of ligand-receptor interactions of the dopamine D2L receptor and their relation to functional selectivity“. Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2006. http://dc.lib.unc.edu/u?/etd,698.
Der volle Inhalt der QuelleTitle from electronic title page (viewed Oct. 10, 2007). " ... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Division of Medicinal Chemistry & Natural Products." Discipline: Medicinal Chemistry and Natural Products; Department/School: Pharmacy. On title page "2L" appears as subscript.