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Thematische Bibliographien / DNA topoisomerasa II beta

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Auswahl der wissenschaftlichen Literatur zum Thema „DNA topoisomerasa II beta“

Autor: Grafiati

Veröffentlicht am 28. Juni 2021

Zuletzt aktualisiert am 29. Juli 2025

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Zeitschriftenartikel zum Thema "DNA topoisomerasa II beta"

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Cowell, Ian G., John W. Casement, and Caroline A. Austin. "To Break or Not to Break: The Role of TOP2B in Transcription." International Journal of Molecular Sciences 24, no. 19 (2023): 14806. http://dx.doi.org/10.3390/ijms241914806.

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Transcription and its regulation pose challenges related to DNA torsion and supercoiling of the DNA template. RNA polymerase tracking the helical groove of the DNA introduces positive helical torsion and supercoiling upstream and negative torsion and supercoiling behind its direction of travel. This can inhibit transcriptional elongation and other processes essential to transcription. In addition, chromatin remodeling associated with gene activation can generate or be hindered by excess DNA torsional stress in gene regulatory regions. These topological challenges are solved by DNA topoisomeras

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Sharma, Kaushal K., Brijendra Singh, Somdutt Mujwar та Prakash S. Bisen. "Molecular Docking Based Analysis to Elucidate the DNA Topoisomerase IIβ as the Potential Target for the Ganoderic Acid; A Natural Therapeutic Agent in Cancer Therapy". Current Computer-Aided Drug Design 16, № 2 (2020): 176–89. http://dx.doi.org/10.2174/1573409915666190820144759.

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Introduction: Intermediate covalent complex of DNA-Topoisomerase II enzyme is the most promising target of the anticancer drugs to induce apoptosis in cancer cells. Currently, anticancer drug and chemotherapy are facing major challenges i.e., drug resistance, chemical instability and, dose-limiting side effect. Therefore, in this study, natural therapeutic agents (series of Ganoderic acids) were used for the molecular docking simulation against Human DNATopoisomerase II beta complex (PDB ID:3QX3). Methods: Molecular docking studies were performed on a 50 series of ganoderic acids reported in t

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Bernard, F. X., S. Sablé, B. Cameron, et al. "Glycosylated flavones as selective inhibitors of topoisomerase IV." Antimicrobial Agents and Chemotherapy 41, no. 5 (1997): 992–98. http://dx.doi.org/10.1128/aac.41.5.992.

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Three flavonoids which promoted Escherichia coli topoisomerase IV-dependent DNA cleavage were isolated from cottonseed flour and identified as quercetin 3-O-beta-D-glucose-[1,6]-O-alpha-L-rhamnose (rutin), quercetin 3-O-beta-D-galactose-[1,6]-O-alpha-L-rhamnose, and quercetin 3-O-beta-D-glucose (isoquercitrin). The most active one (rutin) also inhibited topoisomerase IV-dependent decatenation activity (50% inhibitory concentration, 64 microg/ml) and induced the SOS response of a permeable E. coli strain. Derivatives of quercetin glycosylated at position C-3 were shown to induce two site-specif

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Nitiss, Karin C., Brigid Conroy, Maureen N. McCoy, and John L. Nitiss. "Abstract 2838: Modeling putative oncogenic variants of human topoisomerase II by genome editing of a near haploid cell line." Cancer Research 85, no. 8_Supplement_1 (2025): 2838. https://doi.org/10.1158/1538-7445.am2025-2838.

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DNA topoisomerases (Topos) carry out changes in DNA structure by introducing transient breaks in DNA. These breaks are needed to change DNA conformation, and the enzyme mechanisms minimize possible genome instability from a failure to resolve the cleaved DNA intermediates. Nonetheless, small molecules can interfere with the Topo reaction, leading to elevated DNA cleavage, genome instability and cell death, and this property is the basis of the action of important anti-cancer drugs. Recent work has led to the identification of mutations in eukaryotic Top2 that also result in high levels of Top2

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Jenkins, J. R., M. J. Pocklington, and E. Orr. "The F1 ATP synthetase beta-subunit: a major yeast novobiocin binding protein." Journal of Cell Science 96, no. 4 (1990): 675–82. http://dx.doi.org/10.1242/jcs.96.4.675.

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Novobiocin affects DNA metabolism in both prokaryotes and eukaryotes, resulting in cell death. In prokaryotes, the drug is a specific inhibitor of DNA gyrase, a type II topoisomerase that can be purified on a novobiocin-Sepharose column. The yeast type II topoisomerase is neither the biochemical, nor the genetic target of the antibiotic. We have purified the major yeast novobiocin binding proteins and identified one of them as the beta-subunit of the yeast mitochondrial F1 ATP synthetase, a protein highly conserved throughout evolution. The inactivation of this protein might explain the toxic

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Strehl, Sabine, Karin Nebral, Helmut H. Schmidt, and Oskar A. Haas. "Topoisomerase (DNA) II Beta 180 kDa TOP2B) - A New NUP98 Fusion Partner." Blood 106, no. 11 (2005): 2849. http://dx.doi.org/10.1182/blood.v106.11.2849.2849.

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Abstract The nucleoporin 98 kDa (NUP98) gene has been reported to be fused to 18 different partner genes in various hematological malignancies with 11p15 aberrations. The most frequently observed fusion partners of NUP98 belong to the homeobox family of transcription factors, whereas the non-HOX NUP98 fusion partners comprise a heterogeneous group of genes that are associated with a wide range of biological functions. Cytogenetic analysis of an adult de novo acute myeloid leukemia (AML-M5a) revealed a t(3;11)(p24;p15) indicating fusion of NUP98 with a novel partner gene. Fluorescence in situ h

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Biersack, H., S. Jensen, I. Gromova, I. S. Nielsen, O. Westergaard, and A. H. Andersen. "Active heterodimers are formed from human DNA topoisomerase II alpha and II beta isoforms." Proceedings of the National Academy of Sciences 93, no. 16 (1996): 8288–93. http://dx.doi.org/10.1073/pnas.93.16.8288.

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Muller, M. T., and V. B. Mehta. "DNase I hypersensitivity is independent of endogenous topoisomerase II activity during chicken erythrocyte differentiation." Molecular and Cellular Biology 8, no. 9 (1988): 3661–69. http://dx.doi.org/10.1128/mcb.8.9.3661-3669.1988.

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Endogenous topoisomerase II cleavage sites were mapped in the chicken beta A-globin gene of 12- to 14-day embryonic erythrocytes. A major topoisomerase II catalytic site was mapped to the 5' end of the globin gene which contained a nucleosome-free and DNase I-hypersensitive site and additional but minor sites were mapped to the second intron and 3' of the gene to a tissue-specific enhancer. Cleavage sites, mapped in situ by indirect end labeling, were aligned to single-base-pair resolution by comparison to a consensus sequence derived for vertebrate topoisomerase II catalytic sites. In contras

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Muller, M. T., and V. B. Mehta. "DNase I hypersensitivity is independent of endogenous topoisomerase II activity during chicken erythrocyte differentiation." Molecular and Cellular Biology 8, no. 9 (1988): 3661–69. http://dx.doi.org/10.1128/mcb.8.9.3661.

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Endogenous topoisomerase II cleavage sites were mapped in the chicken beta A-globin gene of 12- to 14-day embryonic erythrocytes. A major topoisomerase II catalytic site was mapped to the 5' end of the globin gene which contained a nucleosome-free and DNase I-hypersensitive site and additional but minor sites were mapped to the second intron and 3' of the gene to a tissue-specific enhancer. Cleavage sites, mapped in situ by indirect end labeling, were aligned to single-base-pair resolution by comparison to a consensus sequence derived for vertebrate topoisomerase II catalytic sites. In contras

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Vassetzky, Y. S., Q. Dang, P. Benedetti, and S. M. Gasser. "Topoisomerase II forms multimers in vitro: effects of metals, beta-glycerophosphate, and phosphorylation of its C-terminal domain." Molecular and Cellular Biology 14, no. 10 (1994): 6962–74. http://dx.doi.org/10.1128/mcb.14.10.6962-6974.1994.

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We present a novel assay for the study of protein-protein interactions involving DNA topoisomerase II. Under various conditions of incubation we observe that topoisomerase II forms complexes at least tetrameric in size, which can be sedimented by centrifugation through glycerol. The multimers are enzymatically active and can be visualized by electron microscopy. Dephosphorylation of topoisomerase II inhibits its multimerization, which can be restored at least partially by rephosphorylation of multiple sites within its 200 C-terminal amino acids by casein kinase II. Truncation of topoisomerase

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Dissertationen zum Thema "DNA topoisomerasa II beta"

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Errington, Fiona. "An investigation into the cytotoxic mechanisms of DNA topoisomerase II poisons and catalytic inhibitors : the role of DNA topoisomerase II alpha and beta." Thesis, University of Newcastle Upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340718.

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Padget, Kay. "Quantitative analysis and drug sensitivity of human DNA topoisomerase II alpha and beta." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246093.

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McNamara, Suzan. "Topoisomerase II beta negatively modulates retinoic acid receptor alpha function : a novel mechanism of retinoic acid resistance in acute promyelocytic leukemia." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115693.

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Interactions between the retinoic acid receptor alpha (RARalpha) and coregulators play a key role in coordinating gene transcription and myeloid differentiation. In acute promyelocytic leukemia (APL), RARalpha is fused with the promyelocytic leukemia (PML) gene, resulting in the expression of the fusion protein PML/RARalpha. Here, I report that topoisomerase II beta (topoIIbeta) associates with and negatively modulates PML/RARalpha and RARalpha transcriptional activity, and increased levels and association of topoIIbeta cause resistance to retinoic acid (RA) in APL cell lines. Knock down of to

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Xue, Yu Lord Susan T. "Study protein-protein interaction in methyl-directed DNA mismatch repair in E. coli exonuclease I Exo I and DNA helicas II UvrD; A minimal exonuclease domain of WRN forms a hexamer on DNA and possesses both 3'-5' exonuclease and 5'-protruding strand endonuclease activities; Solving the structure of the ligand-binding domain of the pregnane-xenobiotic-receptor with 17[beta] estradiol and T1317 /." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,2015.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2008.<br>Title from electronic title page (viewed Feb. 17, 2009). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Chemistry." Discipline: Chemistry; Department/School: Chemistry.

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Burns, Kristi Lee. "An exploration of biochemistry including biotechnology, structural characterization, drug design, and chromatographic analyses." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2006. http://hdl.handle.net/1853/29593.

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Thesis (Ph. D.)--Chemistry and Biochemistry, Georgia Institute of Technology, 2007.<br>Committee Chair: Sheldon W. May ; Committee Members: Donald F. Doyle, Leslie T. Gelbaum, Stanley H. Pollock, and James Powers. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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Jaščevská, Nikola. "Vliv topoisomerasy II beta na citlivost nádorových buněk k protinádorové terapii." Master's thesis, 2021. http://www.nusl.cz/ntk/nusl-446116.

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Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Nikola Jaščevská Supervisor: PharmDr. Anna Jirkovská, Ph.D. Title of diploma thesis: The effects of topoisomerase II beta on the sensitivity of the cancer cells to the antineoplastics Topoisomerase II (TOP II) is a cellular enzyme responsible for solving topological problems of double-stranded DNA. Alpha and beta isoforms of TOP II are different gene products having similar catalytic activities. The expression of TOP IIα is cell-cycle dependent, peaking in G2/M phase, while TOP II isoform is

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Schmidt, Uta [Verfasser]. "Das multifunktionelle Signalprotein Topoisomerase-IIβ-Bindeprotein-1 [Topoisomerase-II-Beta-Bindeprotein-1] (TopBP1) und seine Funktion in der DNA-Schadenserkennung und Replikation / von Uta Schmidt". 2008. http://d-nb.info/990000516/34.

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Karešová, Aneta. "Detekce kovalentních komplexů DNA s proteiny jako metoda stanovení poškození DNA topoizomerázovými jedy." Master's thesis, 2016. http://www.nusl.cz/ntk/nusl-345331.

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Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Aneta Karešová Supervisor: PharmDr. Anna Jirkovská, PhD. Title of diploma thesis: DNA-protein covalent complexes detection as the means for the assessment of the DNA damage induced by topoisomerase poisons. Topoisomerase II is essential cellular enzyme, which modifies the secondary structure of DNA. By introducing a temporary double strand break to DNA it relieves a structural tension raised during transcription and translation. Absolutely indispensable is the role of topoisomerase

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Klieber, Robin. "Použití RNA interference pro ovlivnění hladin DNA topoisomerasy II v nádorových buňkách a její vliv na protinádorový účinek antracyklinových cytostatik." Master's thesis, 2019. http://www.nusl.cz/ntk/nusl-396819.

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Charles University Faculty of Pharmacy in Hradec Králové Department od Biochemical Sciences Candidate: Bc. Robin Klieber Supervisor: PharmDr. Anna Jirkovská, Ph.D. Title of thesis: The use of RNA interference for the modification of DNA topoisomerase II levels in cancer cells and its influence on the antineoplastic effect of anthracyclines. Topoisomerase II (TOP II) is an enzyme that alters the topological state of the DNA double helix during physiological processes through the formation of transient DNA double strand breaks. Two TOP II isoforms are known: TOP IIα is essential for proper separ

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萩原, 和美. "Prox 1 overexpression of Hela cells inhibits PKC beta II transcription through promoter DNA methylation." Thesis, 2012. http://hdl.handle.net/2237/16914.

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Buchteile zum Thema "DNA topoisomerasa II beta"

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Miller, Charles B. "Beta Taxonomy II: Copepods in the Stream of Time." In Oar Feet and Opal Teeth. Oxford University PressNew York, 2023. http://dx.doi.org/10.1093/oso/9780197637326.003.0020.

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Abstract Chapter 20 considers recent reconstructions of arthropod and copepod phylogeny (evolutionary tree branching). Results from DNA and protein amino-acid sequences place the origin of Crustacea early in the Cambrian Period, with divergence of Copepoda at about 500 million years ago. Bios of Rony Huys and Geoffrey Boxshall introduce their work on the definition of copepod orders based on morphological distinctions. Orders are listed with the characters distinguishing them and our present understanding of their divergence sequence. The logics of current algorithms for reconstruction of phyl

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Mohammed Ali Jassim, Marwa, Majid Mohammed Mahmood, and Murtada Hafedh Hussein. "Human Herpetic Viruses and Immune Profiles." In Innate Immunity in Health and Disease. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.96340.

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Herpesviruses are large, spherical, enveloped viral particles with linear double-stranded DNA genome. Herpesvirus virion consists of an icosahedral capsid containing viral DNA, surrounded by a protein layer called tegument, and enclosed by an envelope consisting of a lipid bilayer with various glycoproteins. Herpesviruses persist lifelong in their hosts after primary infection by establishing a latent infection interrupted recurrently by reactivations. The Herpesviridae family is divided into three subfamilies; α-herpesviruses, β-herpesviruses, and γ-herpesviruses based on the genome organizat

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Konferenzberichte zum Thema "DNA topoisomerasa II beta"

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Távora, Fabiano Touzdjian Pinheiro Kohlrausch, Eduardo Andrade Franco Severo, and Ivonaldo Reis Santos. "APLICAÇÃO DA TECNOLOGIA DE SILENCIAMENTO GÊNICO BASEADA EM DNA ANTISENSO VISANDO O AUMENTO DA RESISTÊNCIA EM TOMATEIRO (SOLANUM LYCOPERSICUM L.) À MANCHA BACTERIANA." In II Congresso Brasileiro de Biologia Molecular On-line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/2322.

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Introdução: o tomateiro representa uma das principais hortaliças cultivadas no mundo. Além de sua relevância socioeconômica, seu cultivo é também importante do ponto de vista da segurança alimentar, fornecendo nutrientes essenciais como a vitamina C, pró-vitamina A (i.e., beta-caroteno) e antioxidantes (e.g., licopeno). Dentre as diversas doenças que acometem a cultivo do tomate, a mancha bacteriana do tomateiro (MBT), causada por bactérias do gênero Xanthomonas (com grande destaque para a espécie X. euvesicatoria pv. perforans - Xep), consiste em um fator limitante para a expansão dessa cultu

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Silva, Nicoly Ferreira, JULIA DINIZ DE SOUZA, MELISSA GIOVANNA GOMES RIBEIRO -, SARA DIÓGENES PEIXOTO DE MEDEIROS, and VICTÓRIA RODRIGUES DURAND. "A SEGURANÇA DO MECANISMO DE AÇÃO DAS VACINAS DE RNA MENSAGEIRO CONTRA A COVID-19." In II Congresso Brasileiro de Imunologia On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/ii-conbrai/5987.

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Introdução: A infecção por COVID-19 tem significativo impacto epidemiológico, principalmente pelas taxas de morbimortalidade. Entre as estratégias de prevenção e controle, destaca-se a imunização ativa pelo uso de vacinas, em especial as de RNA mensageiro. Elas possibilitam que as células sintetizam uma proteína S da espícula viral que estimula a resposta imunológica. Porém, associado ao uso desse mecanismo, surgem eventos adversos de hipersensibilidade imediata e tardia. Objetivo: Identificar e ponderar riscos e benefícios associados ao uso de vacinas desenvolvidas a partir de RNA mensageiro

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