Thematische Bibliographien / DNA-Encoded Chemical Library

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  2. Dissertationen
  3. Bücher
  4. Buchteile

Auswahl der wissenschaftlichen Literatur zum Thema „DNA-Encoded Chemical Library“

Autor: Grafiati
Veröffentlicht am 30. Juni 2021
Zuletzt aktualisiert am 29. Juli 2025

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Zeitschriftenartikel zum Thema "DNA-Encoded Chemical Library"

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Dawadi, Surendra, Nicholas Simmons, Gabriella Miklossy, et al. "Discovery of potent thrombin inhibitors from a protease-focused DNA-encoded chemical library." Proceedings of the National Academy of Sciences 117, no. 29 (2020): 16782–89. http://dx.doi.org/10.1073/pnas.2005447117.

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DNA-encoded chemical libraries are collections of compounds individually coupled to unique DNA tags serving as amplifiable identification barcodes. By bridging split-and-pool combinatorial synthesis with the ligation of unique encoding DNA oligomers, million- to billion-member libraries can be synthesized for use in hundreds of healthcare target screens. Although structural diversity and desirable molecular property ranges generally guide DNA-encoded chemical library design, recent reports have highlighted the utility of focused DNA-encoded chemical libraries that are structurally biased for a
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Onda, Yuichi, Gabriele Bassi, Abdullah Elsayed, et al. "A DNA‐Encoded Chemical Library Based on Peptide Macrocycles." Chemistry – A European Journal 27, no. 24 (2021): 7160–67. http://dx.doi.org/10.1002/chem.202005423.

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3

Reddavide, Francesco V., Meiying Cui, Weilin Lin, et al. "Second generation DNA-encoded dynamic combinatorial chemical libraries." Chemical Communications 55, no. 26 (2019): 3753–56. http://dx.doi.org/10.1039/c9cc01429b.

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4

Dumelin, Christoph E., Jörg Scheuermann, Samu Melkko, and Dario Neri. "Selection of Streptavidin Binders from a DNA-Encoded Chemical Library." Bioconjugate Chemistry 17, no. 2 (2006): 366–70. http://dx.doi.org/10.1021/bc050282y.

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5

Faver, John C., Kevin Riehle, David R. Lancia, et al. "Quantitative Comparison of Enrichment from DNA-Encoded Chemical Library Selections." ACS Combinatorial Science 21, no. 2 (2019): 75–82. http://dx.doi.org/10.1021/acscombsci.8b00116.

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6

Stress, Cedric J., Basilius Sauter, Lukas A. Schneider, Timothy Sharpe, and Dennis Gillingham. "A DNA‐Encoded Chemical Library Incorporating Elements of Natural Macrocycles." Angewandte Chemie International Edition 58, no. 28 (2019): 9570–74. http://dx.doi.org/10.1002/anie.201902513.

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7

Edwards, Paul. "Design and synthesis of a novel DNA-encoded chemical library." Drug Discovery Today 15, no. 15-16 (2010): 690–91. http://dx.doi.org/10.1016/j.drudis.2010.06.013.

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8

Dumelin, Christoph E, Sabrina Trüssel, Fabian Buller, et al. "A Portable Albumin Binder from a DNA-Encoded Chemical Library." Angewandte Chemie International Edition 47, no. 17 (2008): 3196–201. http://dx.doi.org/10.1002/anie.200704936.

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9

Dumelin, Christoph E, Sabrina Trüssel, Fabian Buller, et al. "A Portable Albumin Binder from a DNA-Encoded Chemical Library." Angewandte Chemie 120, no. 17 (2008): 3240–45. http://dx.doi.org/10.1002/ange.200704936.

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10

Shi, Ying, Yan-ran Wu, Jian-qiang Yu, Wan-nian Zhang, and Chun-lin Zhuang. "DNA-encoded libraries (DELs): a review of on-DNA chemistries and their output." RSC Advances 11, no. 4 (2021): 2359–76. http://dx.doi.org/10.1039/d0ra09889b.

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We summarize a series of novel DNA-compatible chemistry reactions for DNA-encoded chemical library (DEL) building blocks and analyse the druggability of screened hit molecules via DELs in the past five years.
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Dissertationen zum Thema "DNA-Encoded Chemical Library"

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Geylan, Gökçe. "Training Machine Learning-based QSAR models with Conformal Prediction on Experimental Data from DNA-Encoded Chemical Libraries." Thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-447354.

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DNA-encoded chemical libraries (DEL) allows an exhaustive chemical space sampling with a large-scale data consisting of compounds produced through combinatorial synthesis. This novel technology was utilized in the early drug discovery stages for robust hit identification and lead optimization. In this project, the aim was to build a Machine Learning- based QSAR model with conformal prediction for hit identification on two different target proteins, the DEL was assayed on. An initial investigation was conducted on a pilot project with 1000 compounds and the analyses and the conclusions drawn fr
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Pikalyova, Regina. "Chémoinformatique des chimiothèques à codage ADN : design, génération in silico, gestion, analyse, et comparaison." Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAF032.

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Cette thèse est dédiée à la génération de l'espace virtuel de 2.5K chimiothèques codées par ADN et à leur analyse chémoinformatique détaillée par structures et propriétés. Des méthodologies basées sur GTM permettant de comparer rapidement et de sélectionner les chimiothèques DEL optimales parmi des milliers de possibilités en fonction de la similarité structurelle ou par propriétés par rapport à une base de données de référence ont été développées. Le problème de l'énumération combinatoire des composés a été abordé en développant un modèle d’apprentissage
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Bücher zum Thema "DNA-Encoded Chemical Library"

1

Jr, Robert A. Goodnow. A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug Discovery. Wiley, 2014.

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Buchteile zum Thema "DNA-Encoded Chemical Library"

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Yao, Gang, Xiaojie Lu, Chris Phelps, and Ghotas Evindar. "Chapter 7. DNA-encoded Library Technology (ELT)." In Chemical and Biological Synthesis. Royal Society of Chemistry, 2018. http://dx.doi.org/10.1039/9781788012805-00153.

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2

Melkko, Samu, and Johannes Ottl. "Keeping the Promise? An Outlook on DNA Chemical Library Technology." In A Handbook for DNA-Encoded Chemistry. John Wiley & Sons, Inc., 2014. http://dx.doi.org/10.1002/9781118832738.ch19.

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3

Zhu, Zhengrong. "Selection Method of DNA-Encoded Chemical Library for Irreversible Covalent Binders." In Methods in Molecular Biology. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2545-3_20.

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Reddavide, F. V., S. Heiden, M. Cui, W. Lin, M. Thompson, and Y. Zhang. "3.2.2.3 DNA-Encoded Dynamic Combinatorial Chemical Libraries." In DNA-Encoded Libraries. Georg Thieme Verlag KG, 2024. http://dx.doi.org/10.1055/sos-sd-241-00276.

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AbstractDNA-encoded dynamic combinatorial chemical library (EDCCL) technology is the application of dynamic combinatorial chemistry (DCC) in the field of DNA-encoded library (DEL) technology. EDCCL technology can be used for de novo selection as well as to convert lead compounds into high-affinity bivalent binders. EDCCL technology aims to combine the advantages of DCC and DEL, while addressing some drawbacks from both.
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Keefe, A. D., and A. Litovchick. "3.2.1.3 Chemical Ligation/Encoding." In DNA-Encoded Libraries. Georg Thieme Verlag KG, 2024. http://dx.doi.org/10.1055/sos-sd-241-00198.

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AbstractIn order to generate a library of DNA-encoded chemical compounds it is necessary to covalently attach multiple encoding tracts of DNA to each compound. The most widely practiced methodology to achieve this utilizes the enzymatic ligation of 5'-monophosphate oligodeoxynucleotide tags to 3'-hydroxyl oligodeoxynucleotide tags, typically with recombinant T4 DNA Ligase. This approach can be challenging owing to the inherent incompatibility of conditions supporting the enzymatic activity of T4 DNA Ligase with the specific conditions that are required for each chemical synthesis step. An alte
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Franzini, R. M. "2.10 Reversible Immobilization of DNA for Chemical Modification." In DNA-Encoded Libraries. Georg Thieme Verlag KG, 2024. http://dx.doi.org/10.1055/sos-sd-241-00207.

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AbstractReversible immobilization of DNA molecules on anion-exchange resins allows for stringent washing after on-DNA modification reactions. Furthermore, such an approach allows reactions to be performed under water-free conditions that are otherwise incompatible with DNA-conjugation. Amide-bond formation and coupling of SnAP reagents are presented as examples of reactions on reversibly immobilized oligonucleotides for DNA-encoded library synthesis.
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Migliorini, F., S. Puglioli, D. Neri, S. Cazzamalli, and N. Favalli. "2.2 Metal-Promoted DEL-Compatible C—C Bond Forming Reactions." In DNA-Encoded Libraries. Georg Thieme Verlag KG, 2024. http://dx.doi.org/10.1055/sos-sd-241-00025.

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AbstractDNA-encoded library (DEL) technology relies on the availability of robust and DNA-compatible chemical transformations. Metal-promoted C—C bond forming reactions are widely applied for the synthesis of fine chemicals such as pharmaceuticals. However, their application in DEL technology represents a challenge due to the use of metal catalysts, high temperatures, and organic solvents. In this chapter, we report tailored conditions for the on-DNA application of the Suzuki, Sonogashira, Heck, and Giese reactions. The conditions presented in this chapter have been systematically explored acr
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Granados, A., and G. A. Molander. "2.6 On-DNA Photoredox-Catalyzed Reactions." In DNA-Encoded Libraries. Georg Thieme Verlag KG, 2024. http://dx.doi.org/10.1055/sos-sd-241-00097.

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AbstractThe use of visible light as the driving force to trigger chemical transformations represents an attractive tool for organic synthesis, and it has been demonstrated to be an important and well-established strategy for accessing novel bond connections in a unique way via radical intermediates. This powerful synthetic tool is under continuous development and is finding ever-increasing applications in DNA-encoded library (DEL) synthesis. Since 2018, DEL chemists have new chemical space available thanks to the implementation of visible-light-mediated methods. This chapter details the state-
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Zhang, G., Q. Nie, and J. Sun. "3.1 DNA-Templated Synthesis." In DNA-Encoded Libraries. Georg Thieme Verlag KG, 2024. http://dx.doi.org/10.1055/sos-sd-241-00269.

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Abstract DNA-templated synthesis (DTS) represents a divergent strategy that harnesses the unique nature of DNA hybridization to achieve efficient library synthesis as well as encoding. By using base-pair hybridization to bring the DNA-linked reactants into intramolecular proximity and thus increase their effective local concentration for chemical reaction, DTS translates DNA sequences into the corresponding synthetic products, resembling Nature’s machinery of genetic-code translation. DTS can be applied to generate synthetic products chemically unrelated to the DNA backbone in a sequence-direc
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Su, W., B. Xia, and T. L. Foley. "5.2 On-DNA Resynthesis and Affinity Selection Mass Spectrometry (ASMS)." In DNA-Encoded Libraries. Georg Thieme Verlag KG, 2024. http://dx.doi.org/10.1055/sos-sd-241-00296.

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AbstractA limitation of the split-and-pool approach in creating DNA-encoded libraries (DELs) is that DNA-conjugated side products and starting materials generally cannot be removed during DEL production. Consequently, the same DNA barcode encodes all the products generated during library synthesis (including byproducts) rather than just a single product. In the use of off-DNA resynthesis to confirm hits after affinity selection, a “one-to-one” relationship between the DNA tag and the structure of the attached molecule it encodes is often assumed. However, because library synthesis often yields
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