Thematische Bibliographien / Distorsion product of otoacoustic emissions

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Auswahl der wissenschaftlichen Literatur zum Thema „Distorsion product of otoacoustic emissions“

Autor: Grafiati

Veröffentlicht am 12. April 2025

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Zeitschriftenartikel zum Thema "Distorsion product of otoacoustic emissions"

Stamate, Mirela Cristina, Nicolae Todor und Marcel Cosgarea. „Comparative multivariate analyses of transient otoacoustic emissions and distorsion products in normal and impaired hearing“. Medicine and Pharmacy Reports 88, Nr. 4 (06.11.2015): 500–512. http://dx.doi.org/10.15386/cjmed-467.

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ABSTRACT:Background & aim: The clinical utility of otoacoustic emissions as a noninvasive objective test of cochlear function has been long studied. Both transient otoacoustic emissions and distorsion products can be used to identify hearing loss, but the extent that they can be used as predictors for hearing loss is still debated. Most studies agree that multivariate analyses have better test performances than univariate analyses. The study aims to determine transient otoacoustic emissions and distorsion products performance in identifying normal and impaired hearing loss, using the pure tone audiogram as a gold standard procedure and different multivariate statistical approaches.Patients and methods: The study included 105 adult subjects with normal hearing and hearing loss that underwent the same test battery: pure-tone audiometry, tympanometry, otoacoustic emission tests. We chose to use the logistic regression as a multivariate statistical technique. Three logistic regression models were developped to characterize the relations between different risk factors (age, sex, tinnitus, demographic features, cochlear status defined by otoacoustic emissions) and hearing status defined by pure-tone audiometry. The multivariate analyses allow the calculation of the logistic score, which is a combination of the inputs, weighted by coefficients, calculated within the analyses. The accuracy of the each model was assessed using receiver operating characteristics curve analysis. We used the logistic score to generate receivers operating curves curves and to estimate the areas under the curves in order to compare different multivariate analyses.Results: Each of the three multivariate analyses provides high values of the area under the curves. Each otoacoustic emission test presents small differences for the value of the area under the curve, but transient otoacoustic emissions seems to be the most powerful predictive for the hearing level for the right ear and distorsion products for the left ear. Adding demographic variables, the value of the area under the curve is similar for both ears, but we found out that tinnitus is a strong predictive variable only for the left ear. Our multivariate analyses revealed that age is a predictor factor of the auditory status for both ears. In our study, gender had no predictive value for hearing level in any of the multivariate analyses. Our study also confirms that the combination of age and distorsion products can better predict hearing level than distorsion products alone. We have found out that the otoacoustic emissions tests have improved performance for both ears when using the multivariate analysis which combines transient otoacoustic emissions and distortion products data.Conclusion: Like any other audiological test, using otoacoustic emissions to identify hearing loss is not without error. Even when applying multivariate analysis, perfect test performance is never achieved. Although most studies demonstrated the benefit of using the multivariate analysis, it has not been incorporated into clinical decisions maybe because of the idiosyncratic nature of multivariate solutions or because of the lack of the validation studies.Key words: otoacoustic emissions, multivariate analyses, logistic regression, hearing loss, receiver operating curves.

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Kleinjung, Tobias. „Zusammenhang zwischen Tinnituston und Frequenzbereich des Gehörverlusts“. Laryngo-Rhino-Otologie 97, Nr. 04 (April 2018): 230–31. http://dx.doi.org/10.1055/s-0044-100277.

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Keppler H et al. The relationship between tinnitus pitch and parameters of audiometry and distortion product otoacoustic emissions. J Laryngol Otol 2017; 131: 1017–1025 Ein chronischer Tinnitus ist mit einem reduzierten akustischen Reiz assoziiert. Auf die Schädigung reagiert das zentrale Hörsystem mit Veränderungen. Den Zusammenhang zwischen Tinnituston und Parametern der Audiometrie sowie der distorsiv produzierten otoakustischen Emissionen (DPOAE) untersuchten Ärzte des Hör-Sprachzentrums der Universität der belgischen Stadt Gent.

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Biro, K., L. Noszek, P. Prekopp, K. Vehovszky, E. Nemeth, K. Nagyivanyi, L. Geczi, I. Gaudi und I. Bodrogi. „Spontaneous otoacoustic emissions (SOAE) changes in testicular cancer patients treated with cisplatin: A pilot study of whether the acute ototoxic effect of cisplatin treatment can be detected“. Journal of Clinical Oncology 25, Nr. 18_suppl (20.06.2007): 15581. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.15581.

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15581 Background: We studied the acute ototoxic effect of cisplatin in testicular cancer patients with two highly sensitive new methods for detecting high frequency hearing loss: distorsion product otoacoustic emissions (DPOAE), and spontaneous otoacoustic emissions (SOAE). Methods: Checking the acute effect, 32 (63 ears) testicular cancer patients (median age: 33 years, range: 16–59 years) were measured on the first day of their first cycle and after one week of their last cycle of cisplatin treatment. 20 mg/m2 cisplatin was administered for five days, in BEP chemotherapy regimen. The patients got on the average 2.19 cycles (2–3 cycles). We also measured the SOAE of ten healthy control persons (without chemotherapy) matching sex and age distribution of this group. A detailed medical history evaluated audiological risk factors and hearing problems. Tympanometry, DPOAE and SOAE were measured, to detect the acute changes in the inner ear after low cumulative dose of cisplatin treatment. Paired t-test, and sign test was used for statistical analysis. Results: The DPOAE did not show any changes close after cisplatin treatment (average: 2.19 cycles, 2–3 cycles), similarly to our earlier results with pure tone audiometry (PTA) and transiently evoked otoacoustic emission (TOAE). But the SOAE showed significant, early changes in incidence, shape and amplitude, in the treated group. 66% of the SOAE changed after treatment (p=0,006). In the control group (20 ears) the SOAE never changed in a three months period. (It behaves as a fingerprint) Conclusions: DPOAE did not change significantly after 2 or 3 cycles of cisplatin treatment, similarly to our earlier results with PTA, and TOAE, but the change of the SOAE-incidence, shape and amplitude close after cisplatin treatment shows acute changes in the inner ear function (first described in the literature) after administration of low cumulative dose of cisplatin. This case is the first indication of the possible clinical relevance of SOAE. Our observation has to be confirmed in further studies, with larger number of patients. No significant financial relationships to disclose.

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Negley, Candice, Bharti Katbamna, Teresa Crumpton und Gary D. Lawson. „Effects of Cigarette Smoking on Distortion Product Otoacoustic Emissions“. Journal of the American Academy of Audiology 18, Nr. 08 (September 2007): 665–74. http://dx.doi.org/10.3766/jaaa.18.8.4.

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This study measured distortion product otoacoustic emissions (DPOAEs) and DPOAE input/output (I/O) curves to assess the effects of smoking on cochlear function. Twenty-four healthy adults, 12 smokers and 12 nonsmokers in the 20–30 years age range were selected based on self-reported histories of five to eight years of smoking or no smoking, respectively. All subjects received tympanometric screening to rule out middle ear pathology. Conventional (0.25–8 kHz) and ultra high frequency (UHF; 10–20 kHz) audiometry showed normal or age-appropriate thresholds across both groups. DPOAE results showed small, but significant, decline in DPOAE levels without concomitant changes in noise floors in smokers as compared to nonsmokers. I/O detection thresholds were also significantly elevated at high frequencies in smokers as compared to their nonsmoking counterparts. These findings indicate that smokers are at greater risk for cochlear damage than nonsmokers, and that DPOAE amplitudes and I/O detection thresholds may identify early changes in cochlear function in smokers. Este estudio midió las emisiones otoacústicas por productos de distorsión (DPOAES) y las curvas de ingreso/salida (I/O) de las DPOAE para evaluar los efectos del fumado sobre la función coclear. Veinticuatro adultos, 12 fumadores y 12 no fumadores, en el rango de edad de 20 a 30 años, fueron seleccionados con base en sus historia auto-reportadas de fumado o no fumado en los últimos 5–8 años, respectivamente. Todos los sujetos se sometieron a un tamizaje timpanométrico para descartar patología del oído medio. La audiometría convencional (0.25–8 kHz) y la de ultra-alta frecuencia (UHF, 10–20 kHz) mostraron umbrales normales o apropiados para la edad en ambos grupos. Los resultados de las DPOAE mostraron una caída pequeña pero significativa en los niveles de las DPOAE en los fumadores comparado con los no fumadores, sin cambios concomitantes en el piso de ruido. Los umbrales I/O de detección también estuvieron significativamente elevados en las altas frecuencias en los fumadores, comparado con sus contrapartes no fumadores. Estos hallazgos indican que los fumadores tienen un mayor riesgo de daño coclear que los no fumadores, y que las amplitudes de las DPOAE y los umbrales I/O de detección pueden identificar cambios tempranos en la función coclear de los fumadores.

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Biro, K., L. Noszek, P. Prekopp, K. Nagyiványi, L. Géczi, I. Gaudi und I. Bodrogi. „Characteristics and Risk Factors of Cisplatin-Induced Ototoxicity in Testicular Cancer Patients Detected by Distorsion Product Otoacoustic Emission“. Oncology 70, Nr. 3 (2006): 177–84. http://dx.doi.org/10.1159/000093776.

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Beattie, Randall C. „Distortion Product Otoacoustic Emissions: Comparison of Sequential versus Simultaneous Presentation of Primary-Tone Pairs“. Journal of the American Academy of Audiology 14, Nr. 09 (Oktober 2003): 471–84. http://dx.doi.org/10.1055/s-0040-1715939.

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This Grason-Stadler GSI-60 system for measuring distortion product otoacoustic emissions (DPOAEs) allows the examiner to present one set of primary-tone pairs at a time (i.e., sequential presentation), or to present as many as four sets of primary-tone pairs at a time (i.e., simultaneous presentation). The Sequential and Simultaneous protocols were used to compare administration times, DPOAEs, and noise floors (NFs) on normal-hearing subjects at three frequencies (f2 = 1000, 2000, and 4000 Hz) and eight intensities (L1 = 40–75 dB SPL in 5 dB steps; L2 = 30–65 dB SPL). The Simultaneous protocol was completed in less than half the time (mean = 2 minutes, 21 seconds) required for the Sequential protocol (mean = 5 minutes, 13 seconds). When stimulus intensity (L1) was <60 dB SPL, the Sequential and Simultaneous protocols yielded similar DPOAEs and NFs. However, at the higher L1 intensities, the NFs for the Simultaneous protocol were larger than those for the Sequential protocol. The higher Simultaneous NFs reflect the greater system distortion/noise generated by the GSI-60 instrumentation. Reliability was assessed using the standard error of measurement of the difference between two scores. The data revealed no significant differences between protocols, and suggest that differences between two DPOAEs are statistically significant if they exceed ~7 dB (95% confidence interval). Este sistema Grason-Stadler (GSI-60) para la medición de emisiones otoacústicas por productos de distorsión (DPOAE) permite al examinador la presentación de un juego de pares de tonos primarios al mismo tiempo (p.e., presentación secuencial), o presentar hasta cuatro juegos de pares de tonos primarios a la vez (p.e., presentación simultánea). Se utilizaron los protocolos Secuencial y Simultáneo para comparar los tiempos de administración, las DPOAE y los pisos de ruido (NF) en sujetos normo-oyentes, en tres frecuencias (f2 = 1000, 2000 y 4000 Hz) y ocho intensidades (L1 = 40-75 dB en pasos de 5 dB; L2 = 30-65 dB SPL). El protocolo Simultáneo se completó en menos de la mitad del tiempo (media = 2 minutos, 21 segundos) requerido por el protocolo Secuencial (media = 5 minutos, 13 segundos). Cuando la intensidad del estímulo (L1) fue £60 dB SPL, los protocolos Secuencial y Simultáneo rindieron DPOAE y NF similares. Sin embargo, en las intensidades L1 más altas, los NF para el protocolo Simultáneo fueron mayores que aquellas para el protocolo Secuencial. Los NF Simultáneos más altos reflejan la mayor distorsión/ruido del sistema, generado por la instrumentación del GSI-60. La confiabilidad fue evaluada utilizando el error estándar de medición de la diferencia entre los dos puntajes. Los datos revelaron que no había diferencias significativas entre los protocolos, y sugieren que las diferencias entre dos DPOAE son estadísticamente significativas si exceden ~7 dB (intervalo de confianza del 95%).

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Torre, Peter, Laura E. Dreisbach, Richard Kopke, Ron Jackson und Ben Balough. „Risk Factors for Distortion Product Otoacoustic Emissions in Young Men with Normal Hearing“. Journal of the American Academy of Audiology 18, Nr. 09 (Oktober 2007): 749–59. http://dx.doi.org/10.3766/jaaa.18.9.4.

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The purpose of this study was to evaluate the possible effects of risk factors on distortion product otoacoustic emissions (DPOAEs) in young adult men with normal hearing. Four hundred thirty-six United States Marine recruit men (mean age = 19.2 years ± 1.8 years; age range = 17 - 29 years) participated in this study. Questionnaires were given to each recruit to obtain demographic data and history of noise exposure, solvent exposure, smoking history, and hearing-related histories. Otoscopy, tympanometry, pure-tone air-conduction audiometry (2.0 – 8.0 kHz) and DPOAEs (2.3 - 8.0 kHz) were measured. DPOAE levels were lower in Not Hispanic or Latino recruits, in heavy smokers, in recruits who reported loud live music exposure and ringing in their ears after noise exposure. These differences were not statistically significant at all frequencies. Recruits with multiple risk factors had the lowest DPOAEs as compared to recruits with fewer, or no, risk factors; these differences were not statistically significant. Obtaining risk factor data as part of an audiometric evaluation is important even though the individual may have normal hearing. El propósito de este estudio fue evaluar los posibles efectos de los factores de riesgo sobre las emisiones otoacústicas por productos de distorsión (DPOAE) en hombres adultos jóvenes con audición normal. Cuatrocientos cuarenta y seis reclutas masculinos de la Marina de los Estados Unidos (edad media de 19.2 años ± 1.8; rango de edad = 17 - 29 años) participaron del estudio. Los cuestionarios se entregaron a cada recluta para obtener datos demográficos e historias de exposición a ruido, exposición a solventes, historia de fumado, e historias relacionadas con la audición. Se realizaron otoscopias, timpanometrías, audiometrías de tonos puros por vía aérea (2.0 – 8.0 kHz) y DPOAE (2.3 – 8.0 kHz). Los niveles de las DPOAE fueron más bajos en reclutas no hispánicos o no latinos, en fumadores fuertes, en reclutas que reportaron exposición a música fuerte en vivo, y ruidos en los oídos después de exposición a ruido. Estas diferencias no fueron estadísticamente significativas en todas las frecuencias. Los reclutas con múltiples factores de riesgo tuvieron las DPOAEs más bajas, comparados con los reclutas con menos o ningún dato de factores de riesgo; estas diferencias no fueron estadísticamente significativas. Obtener datos de factores de riesgo como parte de una evaluación audiométrica es importante aunque los individuos tengan audición normal.

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Kossowski, Michel, Thierry Mom, Matthieu Guitton, Jean-Luc Poncet, Pierre Bonfils und Paul Avan. „Fine Alterations of Distortion-product Otoacoustic Emissions after Moderate Acoustic Overexposure in Guinea Pigs: Alteraciones moderadas de los productos de distorsion de las emisiones otoacusticas después de sobrexposición acústica moderada en cobayos“. International Journal of Audiology 40, Nr. 3 (Januar 2001): 113–22. http://dx.doi.org/10.3109/00206090109073106.

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Beattie, Randall C., O. T. Kenworthy und Christina A. Luna. „Immediate and short-term reliability of distortion-product otoacoustic emissions: Confiabilidad inmediata y a corto plazo de las emisiones otoacústicas por productos de distorsión“. International Journal of Audiology 42, Nr. 6 (Januar 2003): 348–54. http://dx.doi.org/10.3109/14992020309101328.

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O'rourke, Clare, Carlie Driscoll, Joseph Kei und Veronica Smyth. „A normative study of distortion-product otoacoustic emissions in 6-year-old schoolchildren: Estudio normativo de las emisiones otoacústicas por productos de distorsión en escolares de 6 años“. International Journal of Audiology 41, Nr. 3 (Januar 2002): 162–69. http://dx.doi.org/10.3109/14992020209077180.

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Dissertationen zum Thema "Distorsion product of otoacoustic emissions"

Rumeau, Cécile. „Évaluation de l'efficacité des réflexes de protection de l'oreille par la mesure des produits de distorsion acoustiques chez le rat : développement d'un nouvel outil clinique pour l'homme“. Thesis, Université de Lorraine, 2013. http://www.theses.fr/2013LORR0091/document.

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L'audiométrie tonale liminaire est l'outil de référence pour évaluer le fonctionnement auditif, mais c'est un outil subjectif qui mesure des élévations de seuils témoignant de dégâts irréversibles sur le système auditif. La mesure des produits de distorsions acoustiques (PDAs), reflet du fonctionnement cochléaire, permet de dépister précocement des altérations de l'oreille interne causées par le bruit ou certains solvants ototoxiques. A partir d'un paradigme de mesure basé sur un enregistrement continu du PDA cubique (2f1-f2) et une stimulation controlatérale, nous avons pu expliquer, chez le rat, les effets pharmacologiques du toluène. Ce solvant aromatique agirait en particulier sur les centres nerveux impliqués dans le réflexe de protection acoustique de l'oreille moyenne. Devant les résultats obtenus chez l'animal, un prototype d'appareil adapté à l'homme a été mis au point, baptisé EchoScan. L'EchoScan a été testé sur 50 volontaires sains normo-entendant lors d'un premier protocole de recherche clinique pour vérifier la reproductibilité des mesures. Un second protocole a ensuite été conduit pour tester l'outil chez des salariés en entreprise, selon plusieurs conditions d'exposition : témoins non exposés, salariés exposés au bruit, exposés aux solvants, exposés au bruit et aux solvants. Les résultats des deux premières conditions sont présentés dans ce mémoire. Ils confirment la pertinence de la mesure du seuil du réflexe de l'oreille moyenne pour évaluer les effets de l'exposition au bruit. Les résultats des sujets exposés aux solvants évalueront la sensibilité de l'EchoScan dans la détection, voir la caractérisation des effets pharmacologiques de substances chimiques (inclusions en cours). Si l'avenir de l'EchoScan apparaît prometteur en médecine du travail, d'autres applications sont envisagées, comme l'étude des effets pharmacologiques des anesthésiques sur le réflexe de l'oreille moyenne
The pure-tone audiometry is a reference tool to assess auditory function but it is able to measure only threshold elevations showing irreversible damages. Measurement of distortion products oto-acoustic emissions (DPOAEs), reflecting the cochlear function, allows early detection of alterations in the inner ear caused by noise or some ototoxic solvents. From paradigm based on a continuous record of cubic DPOAEs (2f1-f2) and a contralateral stimulation triggering the middle-ear reflex, we could explain, in rats, the pharmacological effects of toluene. This aromatic solvent can act on the centers involved in the middle-ear acoustic protection reflex. With the results obtained in animals, a device adapted to humans has been developed, called EchoScan. The EchoScan was tested on 50 healthy volunteers with normal hearing in a first clinical research protocol to verify in particular the reproducibility of its measurements. A second research protocol was then conducted to test this tool among company employees, according to several exposure conditions: unexposed controls, workers exposed to noise, exposed to solvents, exposed to noise and solvents. The results of the first two conditions are presented in this thesis. They confirm the relevance of the measurement of the middle ear reflex threshold in assessing the effects of noise exposure. The results of subjects exposed to solvents will further evaluate the sensitivity of EchoScan in detection of the pharmacological effects, and even in the characterization of chemical substances exposure (in progress). In the future, EchoScan should be particularly promising in occupational medicine, but other applications are already considered, such as the study of pharmacological effects of anesthetics on the middle ear reflex

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Hauchere, Marine. „Evaluation des réponses hautes fréquences des produits de distorsion des otoémissions acoustiques et développement du langage au sein d'une population pédiatrique“. Electronic Thesis or Diss., Université Clermont Auvergne (2021-...), 2024. http://www.theses.fr/2024UCFA0186.

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L'audition des hautes fréquences joue un rôle crucial dans la perception et la compréhension du langage oral. Les fréquences élevées, au-dessus de 2000 Hz, sont essentielles pour discerner les consonnes et autres sons aigus qui portent des informations phonétiques importantes, comme les sifflements et les fricatives (par exemple, les sons "s", "sh", "f", "th"). Une perte auditive dans ces hautes fréquences peut ainsi compromettre la clarté du discours et entraîner des difficultés de compréhension. Il est donc crucial de diagnostiquer et de traiter précocement les déficiences auditives pour minimiser leur impact sur les compétences linguistiques et communicationnelles. Une visite médicale obligatoire est effectuée entre cinq et six ans, en grande section de maternelle ou au CP, pour évaluer le développement de l'enfant et détecter précocement les problèmes pouvant affecter les apprentissages. Cependant, l'évaluation auditive repose sur une audiométrie et les fréquences testées couvrent généralement une plage relativement restreinte, comprise entre 1 et 4 kHz. La mesure des otoémissions acoustiques (OAE) et plus particulièrement des produits de distorsion des OAE (DPOAE) permet d'avoir une information sur l'état de l'oreille interne notamment sur la fonctionnalité des cellules ciliées externes. La plage fréquentielle d'enregistrement peut être plus étendue qu'en routine clinique puisqu'elle permet d'enregistrer des réponses pour des fréquences jusqu'à 10kHz. L'objectif de ce projet de thèse était d'enregistrer les OAE hautes fréquences au sein d'une population pédiatrique afin d'avoir un bilan plus complet de l'audition des enfants. Dans l'étude 1, il s'agissait d'évaluer les hautes fréquences au sein d'une population d'ORL pédiatrique consultant pour différents motifs et d'observer les différences de cette mesure selon le type de pathologie. Les résultats des OAE des enfants ayant un retard de langage ont ensuite été analysés et comparés avec les autres groupes afin de mieux caractériser leur profil auditif. Cependant, en l'absence de bilans orthophoniques disponibles, la classification « retard de langage » était basée sur les observations des parents, des enseignants et des professionnels de la santé, sans permettre de caractériser précisément le trouble en termes de type et de sévérité. Suite à l'étude 1, nous avons cherché à déterminer si, au sein d'une population pédiatrique caractérisée sur le plan langagier, notamment à l'aide d'une batterie d'évaluation du langage oral (ELO), il était possible d'identifier des différences auditives par rapport à une population témoin issue d'écoles maternelles et primaires (étude 2). Les résultats ont permis de montrer qu'il était possible d'enregistrer des réponses physiologiques grâce à la mesure des DPOAE malgré un tympanogramme B. Les résultats suggèrent une relation entre déclenchement du reflexe stapédien et les compétences phonologiques. Dans notre population, les enfants présentant des troubles du langage avaient des amplitudes de réponses aux DPOAE plus importantes que les témoins provenant d'école
High-frequency hearing plays a crucial role in the perception and understanding of spoken language. High frequencies, above 2000 Hz, are essential for discerning consonants and other high-pitched sounds that carry important phonetic information, such as whistles and fricatives (for example, the sounds ‘s', ‘sh', ‘f', ‘th'). Hearing loss in these high frequencies can compromise clarity of speech and lead to comprehension difficulties. It is therefore crucial to diagnose and treat hearing impairment early to minimise its impact on language and communication skills.A compulsory medical check-up is carried out between the ages of five and six, in kindergarten or first grade, to assess the child's development and detect problems that could affect learning at an early stage. However, hearing assessment is based on audiometry, and the frequencies tested generally cover a relatively narrow range, between 1 and 4 kHz.The measurement of acoustic otoemissions (OAE) and more specifically OAE distortion products (DPOAE) provides information on the state of the inner ear, in particular the functionality of the outer hair cells. The recording frequency range can be wider than in routine clinical practice, allowing responses to be recorded at frequencies up to 10 kHz.The aim of this thesis project was to record high-frequency OAEs in a paediatric population in order to obtain a more complete picture of children's hearing. In Study 1, the aim was to evaluate high-frequency hearing in a paediatric ENT population consulting for various reasons and to observe the differences in this measurement according to the type of pathology. The OAE results of children with language delay were then analysed and compared with the other groups in order to better characterise their hearing profile. However, in the absence of available speech and language assessments, the ‘language delay' classification was based on the observations of parents, teachers and health professionals, without making it possible to characterise the disorder precisely in terms of type and severity.Following on from Study 1, we set out to determine whether it was possible to identify auditory differences in a paediatric population characterised in terms of language, in particular using an oral language evaluation battery (ELO), compared with a control population drawn from nursery and primary schools (Study 2). The results showed that it was possible to record physiological responses by measuring DPOAE despite a B tympanogram. The results suggest a relationship between stapedial reflex onset and phonological skills. In our population, children with language disorder had larger amplitudes in DPOAE response than control from schools

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Wathier, Ludivine. „Modifications de l’amplitude du réflexe de l’oreille moyenne après inhalation de solvant. Conséquences physiologiques pour les expositions au bruit“. Thesis, Université de Lorraine, 2016. http://www.theses.fr/2016LORR0211/document.

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Le réflexe de l’oreille moyenne (ROM) diminue l’énergie acoustique portée par les bruits riches en basses fréquences et de fortes intensités qui pénètrent dans la cochlée. Son déclenchement bilatéral permet ainsi de protéger la cochlée. La perturbation de ce réflexe par des solvants peut accroître les effets cochléo-traumatisants du bruit, notamment chez les salariés du secteur industriel, où bruit et solvant sont souvent associés. L’objectif principal de ces travaux était d’élaborer un test de criblage capable d’identifier les substances volatiles susceptibles de modifier le réflexe. De plus, le choix des solvants nous a permis d’étudier le mode d’action des solvants sur les neurones impliqués dans l’arc réflexe. Pour cela, des rats Brown Norway anesthésiés ont été exposés par inhalation aux solvants aromatiques choisis selon leur lipophilie (log Kow) et/ou selon leur structure. L’amplitude du ROM a été déterminée grâce à la mesure de l’intensité du produit de distorsion acoustique. Les résultats montrent que les effets des solvants sur le ROM sont conditionnés par les paramètres stéréospécifiques des molécules et non par leur lipophilie. Par ailleurs, l’analyse RMN des microsomes de cerveaux de rats confirme que le toluène n’influence pas la fluidité membranaire. En conclusion, le ROM est un bon outil pour détecter des substances dangereuses pour l’audition en cas de co-exposition avec du bruit. De plus, nous pouvons dire que les solvants aromatiques ont une action neuropharmacologique et/ou cochléotoxique qui peuvent retentir de façon distincte sur l’audition des sujets co-exposés au bruit et à des solvants
The middle-ear reflex (MER) reduces acoustic energy carried by the high intensity noises rich in low frequencies at entering the cochlea. His bilateral trigger thus protects the cochlea. Disruption of this reflex by solvents can increase cochleo-traumatic effects of noise, especially among industrial workers, where noise and solvent are often associated. The main objective of this work was to develop a screening test capable of identifying the volatile substances that could modify the reflex. Moreover, the choice of solvents allowed us to study the mode of action of solvents on the neurons involved in the reflex circuit. For this purpose, Brown Norway rats were anesthetized and then exposed to aromatic solvents selected according to their lipophilicity (log Kow) and/or their structure. The amplitude of the MER is determined by measuring cubic distortion product oto-acoustic emissions. For that, aromatic solvents appear to act directly on the neuronal targets involved in the acoustic reflex circuit, rather than on membrane fluidity. The affinity of this interaction is determined by stereospecific parameters rather than lipophilocity. Additionally, NMR spectra for brain microsomes confirmed that brain lipid fluidity was unaffected by toluene exposure. In conclusion, the MER can be used to detect hazardous volatiles substances for the hearing when co-exposed to noise. Moreover, this study revealed that aromatic solvents have a neuropharmacological and/or cochleotoxic action that can act separately on the hearing of workers exposed to noise and solvents simultaneously

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Picton, Peter Evan. „Multiple tone pair distortion product otoacoustic emissions“. Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0002/MQ45426.pdf.

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Tringali, Stéphane. „Contribution de la stimulation magnétique transcranienne répétitive à l’étude de la modulation centrale du fonctionnement cochléaire chez le sujet normo-entendant“. Thesis, Lyon 1, 2011. http://www.theses.fr/2011LYO10289.

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Le système auditif ascendant est constitué d’étages multiples procédant chacun à un traitement complexe du signal, traitement qui est modulé par un système descendant, formant de multiples boucles corticales et sous-corticales de rétroaction : le système efférent auditif. La boucle la plus longue de ce système serait capable de moduler directement le fonctionnement des cellules sensorielles de l’organe périphérique de l’audition. Le but de ce travail était d’étudier pour la première fois chez le sujet sain, l’effet d’une modulation corticale expérimentale sur le fonctionnement périphérique auditif. Nous avons donc recueilli, dans le cadre d’un protocole en double aveugle contre placebo, chez 34 sujets sains, l’activité des cellules ciliées externes de l’organe de Corti (cellules sensorielles directement en contact avec les fibres nerveuses efférentes), par le recueil d’otoémissions acoustiques (OEAs), avant et après stimulation du cortex auditif par une stimulation magnétique transcrânienne répétitive (SMTr). Une diminution de l’amplitude d’un type d’OEA a été obtenue du côté controlatéral à une stimulation du cortex auditif par SMTr à 10 Hz, effet qui ne peut être expliqué seulement par une action non-spécifique liée au bruit de la SMTr mais qui reste extrêmement variable d’un sujet à un autre. De plus, nous avons montré, du côté ipsilatéral à la SMTr, une diminution de l’amplitude des OEAs immédiatement après la SMTr, et uniquement pour les fortes intensités d’utilisation de la SMTr (donc, pour des niveaux de bruit plus importants), reflétant un effet direct du bruit de la SMTr sur les mécanismes cochléaires actifs, effet présent chez nos sujets même en cas de protections auditives de bonne qualité
The ascending auditory system involves multiples stages where the auditory information is processed and modulated by a top-down influence involving multiple cortico sub-cortical loops: the efferent auditory system. It is hypothesized that the longest loop of this efferent system is able to modulate directly the sensory cells of the peripheral auditory organ. The aim of this work was to study this system, to our knowledge for the first time in healthy humans, and to show a direct cortical influence on the auditory periphery. In a double blind randomized procedure, we recorded, in 34 healthy subjects, the activity of outer hair cells of the organ of Corti (sensory cells, that are in direct synaptic contact with medial efferent fibers), by means of evoked otoacoustic emissions (OAEs), before and after auditory cortex stimulation by repetitive transcranial magnetic stimulation (rTMS). We showed an inhibitory influence of the auditory cortical stimulation by 10 Hz rTMS on OAE amplitudes, predominantly in the ear contralateral to the rTMS, effect that cannot be attributed to a non-specific effect linked to the impulse noise associated with the rTMS technique, but that remains highly variable across subjects. In addition, we showed a decrease in OAE amplitude on the ipsilateral side, immediately after the rTMS session and only for high rTMS intensities (and hence, higher noise levels), that reflect a direct influence of the rTMS noise on the auditory periphery, effect that is present even in well ear-protected subjects

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MacFarlane, Lucy. „Time domain visualisation of distortion product otoacoustic emissions“. Thesis, University of Southampton, 2016. https://eprints.soton.ac.uk/393739/.

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Distortion product otoacoustic emissions (DPOAEs) are small sounds believed to be the combination of distortion and reflection energy produced by the cochlea in response to stimulation with simultaneous pure tones. Although used clinically, the exact generation mechanisms associated with DPOAEs are not clear; this is especially the case for 2f2-f1. It is thought that 2f1-f2 and 2f2-f1 DPOAEs contain reflection (R) and distortion (D) energy; the D energy may arise from the region of overlap between the stimulus travelling waves while R energy is reflected from fixed points along the basilar membrane. Cochlear mechanics would suggest the two emissions cannot arise from the same cochlear location; current theories suggest the f2 characteristic place is important to 2f1-f2 while 2f2-f1 is generated more basally. Theories of DPOAE generation have been investigated using various techniques , including time domain investigations. Time domain investigations have often used the phase gradient latency (PGL) technique but this has inherent limitations. An alternative approach is primary tone phase variation (PTPV) - a phase rotation method described by Whitehead et al. (1996) that allows for specific DPOAEs to be extracted. This study has used PTPV to investigate DPOAEs generated by an ISVR developed cochlear model and DPOAEs recorded from 40 normal hearing ears (across two experiments); the overall aim of the study is to learn more about the generation of 2f1-f2 and 2f2-f1 emissions by viewing DPOAEs in the time domain with PTPV. Specific areas of interest are the effect of frequency ratio and primary ramping on the time course of 2f1-f2 and 2f2-f1, and how the time course of emissions varies with stimulus level and fine structure position. It is believed these areas will allow for theories of DPOAE generation to be tested. Output from simulations and recorded emissions supports what is already known and theorised about DPOAE generation. It would appear that 2f1-f2 and 2f2-f1 are the product of multiple components originating from a distributed cochlear source. Temporal behaviour of emissions is influenced by stimulus parameters including level, frequency and ratio. This investigation has contributed to knowledge by studying 2f1-f2 and 2f2-f1 emissions with the PTPV procedure and a novel onset latency estimation technique. Data was collected from a group of normal hearing participants and compared to output of a cochlear model.

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Sung, Lui, und 宋蕾. „Multifrequency tympanometry and distortion product otoacoustic emissions in neonates“. Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31251110.

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Young, Jacqueline Ann. „Modelling the cochlear origins of distortion product otoacoustic emissions“. Thesis, University of Southampton, 2011. https://eprints.soton.ac.uk/175357/.

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Distortion product otoacoustic emissions (DPOAEs) arise within the cochlea in response to two stimulus tones (f1 and f2) at frequencies such as 2f1 − f2 and 2f2 − f1. Each DPOAE derives from two contributing mechanisms within the cochlea: a distributed distortion source and a reflection source. They are used for hearing screening, but a better understanding of their cochlear origin and transmission could potentially extend their clinical application to facilitate objective hearing loss assessment, differential diagnosis of sensorineural hearing losses and improved auditory rehabilitation using hearing aids. In this thesis a numerical model of the human cochlea is developed to study the generation of DPOAEs. It is based on a pre-existing active nonlinear model, the micromechanics of which are carefully re-tuned to simulate the response of the human cochlea to single- and two- tone stimulation. Particular attention is paid to the form and position of the nonlinearity within the model to best match experimental results. The model is also reformulated to verify its stability and ensure computational convergence of the iterative frequency domain solution method. Its predictions are validated against estimated time domain simulations and documented experimental DPOAE measurements. Additionally a novel method is developed for decomposing each frequency component of the cochlear response into forward and backward travelling waves, which is applied to investigate the multiple sources of both the 2f1 − f2 and 2f2 − f1 DPOAEs. The model is used to explain and predict a variety of phenomena observed in experimental DPOAE studies. It also confirms for the 2f1 − f2 emission, that the two source mechanisms are spatially separated and that the only significant reflection contribution is associated with the 2f1 − f2 travelling wave. In contrast, it predicts that the two source mechanisms will overlap in the case of the 2f2 − f1 DPOAE, which can be influenced by reflection of both the primary and 2f2 − f1 travelling waves.

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Sung, Lui. „Multifrequency tympanometry and distortion product otoacoustic emissions in neonates /“. Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B22008342.

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Mauermann, Manfred Dieter. „Fine structure in distortion product otoacoustic emissions and auditory perception“. [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972885544.

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Bücher zum Thema "Distorsion product of otoacoustic emissions"

Picton, Peter Evan. Multiple tone pair distortion product otoacoustic emissions. Ottawa: National Library of Canada, 1999.

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Fung, George Ka-Chung. The effect of vestibular stimulation on distortion product otoacoustic emissions. Ottawa: National Library of Canada = Bibliothèque nationale du Canada, 1999.

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Jaffer, Taha. Longitudinal elasticity of the cochlear partition and distortion product otoacoustic emissions. Ottawa: National Library of Canada, 2000.

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Kulik, Robert Stanley. A synchronous averaging instrument for the measurement of distortion product otoacoustic emissions. Ottawa: National Library of Canada, 1995.

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Pienkowski, Martin. Evidence for a relationship between the suppression of distortion product otoacoustic emissions hearing threshold. Ottawa: National Library of Canada, 2000.

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Harkcom, Joanne. The relationship between smoking and hearing as measured by pure tones, transient evoked otoacoustic emissions, and distortion product otoacoustic emissions. 2001.

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Jaffer, Taha. Longitudinal elasticity of the Cochlear Partition and distortion product otoacoustic emissions. 2000, 2000.

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Jaffer, Taha. Longitudinal elasticity of the cochlear partition and distortion product otoacoustic emissions: How dead ears produce sounds. 2002.

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Tunnell, Jenne L. A study of the influence of contralateral noise on distortion product otoacoustic emissions among an aging population. 1998.

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Buchteile zum Thema "Distorsion product of otoacoustic emissions"

Dalhoff, E., D. Turcanu und A. W. Gummer. „Laserinterferometrically measured distortion product otoacoustic emissions“. In IFMBE Proceedings, 285–88. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-03891-4_76.

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Filipo, R., G. Attanasio, M. Barbaro, M. Viccaro, A. Musacchio, G. Cappelli und E. De Seta. „Distortion Product Otoacoustic Emissions in Otosclerosis: Intraoperative Findings“. In Otosclerosis and Stapes Surgery, 133–36. Basel: KARGER, 2007. http://dx.doi.org/10.1159/000098756.

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Ganz, Michael, und Hellmut von Specht. „Distortion-Product Otoacoustic Emissions Related to Physiological and Psychophysical Aspects of Hearing“. In Acoustical Signal Processing in the Central Auditory System, 555–60. Boston, MA: Springer US, 1997. http://dx.doi.org/10.1007/978-1-4419-8712-9_51.

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Harris, F. P., und R. Probst. „Growth Functions of Tone Burst Evoked and Distortion-Product Otoacoustic Emissions in Humans“. In Lecture Notes in Biomathematics, 178–85. New York, NY: Springer New York, 1990. http://dx.doi.org/10.1007/978-1-4757-4341-8_22.

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Wiederhold, Michael L. „Effects of Tympanic Membrane Modification on Distortion Product Otoacoustic Emissions in the Cat Ear Canal“. In Lecture Notes in Biomathematics, 251–58. New York, NY: Springer New York, 1990. http://dx.doi.org/10.1007/978-1-4757-4341-8_31.

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Janssen, T., und J. Müller. „Distortion product otoacoustic emissions - a tool for assessing the non-linear sound amplification of the ear“. In IFMBE Proceedings, 37–40. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-03891-4_10.

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Probst, Rudolf, und Frances P. Harris. „Chapter 9 A comparison of transiently evoked and distortion-product otoacoustic emissions in humans“. In Natural and Artificial Control of Hearing and Balance, 91–99. Elsevier, 1993. http://dx.doi.org/10.1016/s0079-6123(08)62266-9.

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Lonsbury-Martin, Brenda L., Martin L. Whitehead und Glen K. Martin. „Chapter 8 Distortion-product otoacoustic emissions in normal and impaired ears: insight into generation processes“. In Natural and Artificial Control of Hearing and Balance, 77–90. Elsevier, 1993. http://dx.doi.org/10.1016/s0079-6123(08)62265-7.

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„Noninvasive Assessment of Auditory Function in Mice: Auditory Brainstem Response and Distortion Product Otoacoustic Emissions“. In Handbook of Mouse Auditory Research, 51–72. CRC Press, 2001. http://dx.doi.org/10.1201/9781420038736-8.

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Manley, G. A., und C. Köppl. „A Quantitative Comparison of Peripheral Tuning Measures: Primary Afferent Tuning Curves Versus Suppression Tuning Curves of Spontaneous and Distortion-product Otoacoustic Emissions“. In Auditory Physiology and Perception, 151–58. Elsevier, 1992. http://dx.doi.org/10.1016/b978-0-08-041847-6.50023-x.

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Konferenzberichte zum Thema "Distorsion product of otoacoustic emissions"

VAN DIJK, PIM, und SEBASTIAAN W. F. MEENDERINK. „DISTORTION PRODUCT OTOACOUSTIC EMISSIONS IN THE AMPHIBIAN EAR“. In Proceedings of the Ninth International Symposium. WORLD SCIENTIFIC, 2006. http://dx.doi.org/10.1142/9789812773456_0055.

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MEENDERINK, SEBASTIAAN W. F., und MARCEL VAN DER HEIJDEN. „DISTORTION PRODUCT OTOACOUSTIC EMISSIONS EVOKED BY TONE COMPLEXES“. In Proceedings of the 10th International Workshop on the Mechanics of Hearing. WORLD SCIENTIFIC, 2009. http://dx.doi.org/10.1142/9789812833785_0034.

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NISHIMURA, M., K. DOI, T. HASEGAWA, A. UNO, Y. UNO, M. KAWAMOTO, H. HIBINO und T. KUBO. „DISTORTION PRODUCT OTOACOUSTIC EMISSIONS IN RODENTS WITH IMPAIRED COCHLEA“. In Proceedings of the International Symposium. WORLD SCIENTIFIC, 2000. http://dx.doi.org/10.1142/9789812793980_0066.

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Lee, Jungmee, und Glenis R. Long. „Distortion product otoacoustic emissions generated by mistuned harmonic stimuli“. In 184th Meeting of the Acoustical Society of America. ASA, 2023. http://dx.doi.org/10.1121/2.0001765.

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Keshishzadeh, Sarineh, und Sarah Verhulst. „Individualized Cochlear Models Based on Distortion Product Otoacoustic Emissions“. In 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). IEEE, 2021. http://dx.doi.org/10.1109/embc46164.2021.9629808.

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Dong, Wei, Elizabeth S. Olson, Christopher A. Shera und Elizabeth S. Olson. „Generation of Distortion Product Otoacoustic Emissions in the Gerbil Cochlea“. In WHAT FIRE IS IN MINE EARS: PROGRESS IN AUDITORY BIOMECHANICS: Proceedings of the 11th International Mechanics of Hearing Workshop. AIP, 2011. http://dx.doi.org/10.1063/1.3658097.

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Vencovský, Václav, und Aleš Vetešník. „Theoretical study on onset of cubic distortion product otoacoustic emissions“. In TO THE EAR AND BACK AGAIN - ADVANCES IN AUDITORY BIOPHYSICS: Proceedings of the 13th Mechanics of Hearing Workshop. Author(s), 2018. http://dx.doi.org/10.1063/1.5038539.

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Wu, Hongde, Jieqing Cai, Hongzheng Zhang und Fei Chen. „A Correlational Analysis between Audiometric Pure-tone Averages and Distortion Product Otoacoustic Emissions“. In 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). IEEE, 2022. http://dx.doi.org/10.1109/embc48229.2022.9871638.

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NEELY, S. T., M. P. GORGA und P. A. DORN. „GROWTH OF DISTORTION-PRODUCT OTOACOUSTIC EMISSIONS IN A NONLINEAR, ACTIVE MODEL OF COCHLEAR MECHANICS“. In Proceedings of the International Symposium. WORLD SCIENTIFIC, 2003. http://dx.doi.org/10.1142/9789812704931_0072.

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Chen, Shixiong, Lin Bian, Christopher A. Shera und Elizabeth S. Olson. „Cochlear Gain Control Estimated from Distortion Product Otoacoustic Emissions Evoked by Amplitude Modulated Tones“. In WHAT FIRE IS IN MINE EARS: PROGRESS IN AUDITORY BIOMECHANICS: Proceedings of the 11th International Mechanics of Hearing Workshop. AIP, 2011. http://dx.doi.org/10.1063/1.3658156.

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Berichte der Organisationen zum Thema "Distorsion product of otoacoustic emissions"

Head, Jodi. The Effects of Ear Canal Pressure Variation on Distortion Product Otoacoustic Emissions. Portland State University Library, Januar 2000. http://dx.doi.org/10.15760/etd.7095.

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Lavoie, Kimberly. High Frequency Pure Tone Audiometry and High Frequency Distortion Product Otoacoustic Emissions: A Correlational Analysis. Portland State University Library, Januar 2000. http://dx.doi.org/10.15760/etd.1688.

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