Auswahl der wissenschaftlichen Literatur zum Thema „Dihydroxypyrimidines“
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Zeitschriftenartikel zum Thema "Dihydroxypyrimidines"
Powdrill, Megan H., Jerome Deval, Frank Narjes, Raffaele De Francesco und Matthias Götte. „Mechanism of Hepatitis C Virus RNA Polymerase Inhibition with Dihydroxypyrimidines“. Antimicrobial Agents and Chemotherapy 54, Nr. 3 (22.12.2009): 977–83. http://dx.doi.org/10.1128/aac.01216-09.
Der volle Inhalt der QuelleGuo, Di-Liang, Xing-Jie Zhang, Rui-Rui Wang, Yu Zhou, Zeng Li, Jin-Yi Xu, Kai-Xian Chen, Yong-Tang Zheng und Hong Liu. „Structural modifications of 5,6-dihydroxypyrimidines with anti-HIV activity“. Bioorganic & Medicinal Chemistry Letters 22, Nr. 23 (Dezember 2012): 7114–18. http://dx.doi.org/10.1016/j.bmcl.2012.09.070.
Der volle Inhalt der QuelleNovais, H. M., und S. Steenken. „Reactions of oxidizing radicals with 4,6-dihydroxypyrimidines as model compounds for uracil, thymine, and cytosine“. Journal of Physical Chemistry 91, Nr. 2 (Januar 1987): 426–33. http://dx.doi.org/10.1021/j100286a034.
Der volle Inhalt der QuelleTelvekar, Vikas N., und Kavitkumar N. Patel. „Pharmacophore Development and Docking Studies of the HIV-1 Integrase Inhibitors Derived from N-methylpyrimidones, Dihydroxypyrimidines, and Bicyclic Pyrimidinones“. Chemical Biology & Drug Design 78, Nr. 1 (25.05.2011): 150–60. http://dx.doi.org/10.1111/j.1747-0285.2011.01130.x.
Der volle Inhalt der QuelleAstrat'ev, A. A., D. V. Dashko, A. Yu Mershin, A. I. Stepanov und N. A. Urazgil'deev. „ChemInform Abstract: Some Specific Features of Acid Nitration of 2-Substituted 4,6-Dihydroxypyrimidines. Nucleophilic Cleavage of the Nitration Products.“ ChemInform 32, Nr. 51 (23.05.2010): no. http://dx.doi.org/10.1002/chin.200151070.
Der volle Inhalt der QuelleWinterbourn, Christine C., und Rex Munday. „Concerted Action Of Reduced Glutathione And Superoxide Dismutase In Preventing Redox Cycling Of Dihydroxypyrimidines, And Their Role In Antioxidant Defence“. Free Radical Research Communications 8, Nr. 4-6 (Januar 1990): 287–93. http://dx.doi.org/10.3109/10715769009053361.
Der volle Inhalt der QuelleJansa, Petr, Antonín Holý, Martin Dračínský, Viktor Kolman, Zlatko Janeba, Petra Kostecká, Eva Kmoníčková und Zdeněk Zídek. „5-Substituted 2-amino-4,6-dihydroxypyrimidines and 2-amino-4,6-dichloropyrimidines: synthesis and inhibitory effects on immune-activated nitric oxide production“. Medicinal Chemistry Research 23, Nr. 10 (09.05.2014): 4482–90. http://dx.doi.org/10.1007/s00044-014-1018-9.
Der volle Inhalt der QuelleShi, Daqing, Lihui Niu und Qiya Zhuang. „Clean synthesis of pyrido[2,3-d]pyrimidines in aqueous media“. Journal of Chemical Research 2005, Nr. 10 (Oktober 2005): 648–50. http://dx.doi.org/10.3184/030823405774663048.
Der volle Inhalt der QuelleKufelnicki, Aleksander, Jan Jaszczak, Urszula Kalinowska-Lis, Cecylia Wardak und Justyn Ochocki. „Complexes of Uracil (2,4-Dihydroxypyrimidine) Derivatives“. Journal of Solution Chemistry 35, Nr. 5 (Mai 2006): 739–51. http://dx.doi.org/10.1007/s10953-006-9017-1.
Der volle Inhalt der QuelleNovais, H. M., und S. Steenken. „ESR studies of electron and hydrogen adducts of thymine and uracil and their derivatives and of 4,6-dihydroxypyrimidines in aqueous solution. Comparison with data from solid state. The protonation at carbon of the electron adducts“. Journal of the American Chemical Society 108, Nr. 1 (Januar 1986): 1–6. http://dx.doi.org/10.1021/ja00261a001.
Der volle Inhalt der QuelleDissertationen zum Thema "Dihydroxypyrimidines"
Garlatti, Laura. „Development of Bunyavirales endonucleases inhibitors by in situ click chemistry“. Electronic Thesis or Diss., Aix-Marseille, 2022. http://www.theses.fr/2022AIXM0586.
Der volle Inhalt der QuelleWith a worldwide repartition and limited therapeutic options Bunyavirales viruses represent a major public health issue. The replication machinery of these viruses is governed by the intricate L-protein that displays an endonuclease activity responsible for the cap-snatching mechanism that allows viral transcription. This key enzyme was identified as a promising target to develop antivirals. Its catalytic mechanism of RNA hydrolysis mediated by Mg2+ ions enables the development of diketo acid (DKA) metal-chelating inhibitors. Target-Guided-Synthesis (TGS) is a powerful method that directly involves the therapeutic target that assembles its own inhibitors in its active site like LEGOs®. Herein, we describe the use of Bunyavirales endonucleases as reaction vessels for the In Situ generation of metal-chelating inhibitors. A library of 25 N-triazolyl-DKA (NT-DKA), C-triazolyl-DKA (CT-DKA) and C-triazolyl-DHP (CT-DHP) compounds was generated with new and original synthesis pathways via click chemistry. The compounds were biophysically characterized by Microscale Thermophoresis (MST) and Differential Scanning Fluorimetry (DSF) and their inhibitory potency was evaluated in vitro and in infected cells culture. Moreover, a fluorescein-DKA ligand was synthesized for the development of a competition Fluorescence Polarization (FP) assay to determine the activity of the compounds. High-affinity ligands that demonstrated a potent efficiency in vitro and in cellula were identified. In the context of the COVID-19 pandemic, the compounds library was repositioned against SARS-CoV-2 exonuclease which opened new possibilities for the development of metal-chelating Coronavirus inhibitors
Chen, Hui-Fang, und 陳惠芳. „Self-Assembly of dihydroxypyrimidine-based Metal Complexes“. Thesis, 2007. http://ndltd.ncl.edu.tw/handle/40715693163039617195.
Der volle Inhalt der Quelle中國文化大學
應用化學研究所
95
Abstract This thesis focuses on the preparation of novel-based metal-organic frameworks based on nucleobases via self-assembly strategy and the study of the influence of pH-values and alkali hydroxide (NaOH, KOH, CsOH). We chosen two uracil-derivatives 4,6-dihydroxypyrimidine (dhp-H2) and 2,4-dihydroxypyrimidine-5-carboxylic acid (H3L1), and 2-methyl-1H-benzo[d]imidazole-5-carboxylic acid (H2L2), as potential organic ligands. At first, assembly of Ni2+, Co2+or Zn2+ ions with dhp-H2 in water or alcohol at ambient temperature led to the formation of discrete molecules, [Ni(Hdhp)2(H2O)4] (HF-1) and [Co(Hdhp)2(H2O)4] (HF-2), and three-dimensional metal-organic frameworks [Co(dhp)(H2O)]n (HF-3) and [Zn(dhp)(H2O)]n (HF-4). It is found that pH-values has a dramatically effect for the preparation of HF-1－HF-4. The aptitude range of pH-values for HF-1 and HF-2 is from 9 to 10, while for HF-3 and HF-4, the values range from 11 to12. When Tb3+and Eu3+ is reacted with H3L in water or alcohol at ambient temperature, compound {K2[Tb(H2L1)4(OH)]．2H2O}n (HF-5), {K2[Eu(H2L1)4(OH)]．2H2O}n (HF-6) and [Tb(H2L1)(HL1)(H2O)4]．3H2O (HF-7) were obtained. In this system, the influence of pH-value to the formation of HF-5－HF-7 was also observed. The aptitude range of pH-values for HF-5－HF-7 is from 9 to 10. Finally, the self-assembly reaction of Cu2+ and 2-methyl-1H-benzo[d]imidazole-5-carboxylic acid in water or alcohol at ambient temperature gave compound {[Cu(HL2)2(H2O)]．1/2 H2O }n (HF-8) , which adopts a one-dimensional chain-like architecture. The solid-state structures of the products were characterized by single-crystal X-ray diffraction analyses and their properties were examined by TGA and PXRD, etc.
Chen, Han-Yin, und 陳函听. „Self-assembly, Structures, and Properties of Coordination Compounds Based on Dihydroxypyrimidine“. Thesis, 2013. http://ndltd.ncl.edu.tw/handle/psfr2d.
Der volle Inhalt der Quelle國立臺北科技大學
化學工程研究所
101
This thesis focuses on the preparation of based metal–organic frameworks based on nucleobases via a self-assembly strategy. Two uracil-derivatives, 4,6-dihydroxypyrimidine (H2dhp) and 2,4-dihydroxypyrimidine-5-carboxylic acid (H3dhpca), were selected for use as potential organic ligands. The assembly of CaII, NiII ions with 4,6-dihydroxypyrimidine (H2dhp) in water or alcohol at ambient temperature led to the formation of the discrete molecule [Ni(Hdhp)2(H2O)4] (1) and a 2D metal–organic frameworks {[Ca(Hdhp)2(H2O2)]•THF}n (2). When MnII, MgII and ZnII were reacted with 2,4-dihydroxypyrimidine-5-carboxylic acid (H3dhpca) in water or alcohol at ambient temperature, the discrete compounds [Mn(H2dhpca)2(H2O)2] (3), {[Mg(H2-dhpca)2(H2O)2]•2H2O} (4) , and {[K2(H2O)6][Zn(H2dhpca)2(H2O)2]} (5) were produced. The solid-state structures of the products were characterized by single-crystal X-ray diffraction analyses and their thermal stabilities were examined by TGA method.
Buchteile zum Thema "Dihydroxypyrimidines"
Ishikawa, T. „From 5-Amino-2,6-dihydroxypyrimidine-4-carboxylic Acid“. In Six-Membered Hetarenes with Two Identical Heteroatoms, 1. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-016-01777.
Der volle Inhalt der QuelleKonferenzberichte zum Thema "Dihydroxypyrimidines"
Vu, Tuan, Xuan Nguyen, Nikolai Yudin und Alexander Kushtaev. „KINETICS AND NITRATION MECHANISM OF 4,6-DIHYDROXYPYRIMIDINE AND ITS DERIVATIVES IN THE PRESENCE OF NITROUS ACID“. In Chemistry of nitro compounds and related nitrogen-oxygen systems. LLC MAKS Press, 2019. http://dx.doi.org/10.29003/m752.aks-2019/199-205.
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