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1

Mohammad, Jamshidi, Hrsg. Time-delay systems: Analysis, optimization, and applications. Amsterdam: North-Holland, 1987.

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2

Jiri, Kvasnicka, Hrsg. A novel approach to optimization of paced AV delay using atrial contribution index. New York: Nova Science Publishers, 2008.

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3

Optimal periodic control. Berlin: Springer-Verlag, 1988.

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4

Optimization in public transportation: Stop location, delay management and tariff zone design in a public transportation network. New York: Springer, 2006.

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5

Lu, Ko Ke. Design of group-delay equalizers and linear-phase filters using minimax optimization. 1986.

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6

Schöbel, Anita. Optimization in Public Transportation: Stop Location, Delay Management and Tariff Zone Design in a Public Transportation Network (Springer Optimization and Its Applications). Springer, 2006.

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7

United States. National Aeronautics and Space Administration., Hrsg. Process product integrity audits: A hardware auditing technique for the "90s". [Washington, DC: National Aeronautics and Space Administration, 1997.

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8

Schöbel, Anita. Optimization in Public Transportation: Stop Location, Delay Management and Tariff Zone Design in a Public Transportation Network (Springer Optimization and Its Applications Book 3). Springer, 2007.

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9

Schöbel, Anita. Optimization in Public Transportation: Stop Location, Delay Management and Tariff Zone Design in a Public Transportation Network. Springer, 2010.

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10

Modell, Jerome H., und Sean Kiley. Pathophysiology and management of drowning. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0348.

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Drowning is a process beginning with airway submergence under a fluid medium, progressing to aspiration, and ultimately death in the absence of intervention. Aspiration of both fresh- and saltwater can cause pulmonary oedema, decreased compliance, intrapulmonary shunting, and severe hypoxia. Devastating neurological injury resulting from prolonged cerebral hypoxia is proportional to the duration of submersion and delay in effective resuscitation and oxygenation. Victims presenting to the emergency department awake and alert, or even stuporous, are likely to have a good neurological outcome with follow-up intensive care. Those presenting comatose are much more likely to have severe neurological deficits. Keys to survival are: timely rescue from the water, immediate initiation of aggressive supportive care regarding airway, cardiovascular and pulmonary function, and optimization of tissue oxygenation.
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11

Dodds, Chris, Chandra M. Kumar und Frédérique Servin. Emergency anaesthesia in the elderly. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198735571.003.0006.

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Emergency surgery in the elderly is needed even if elective surgery would not be considered. Often, it is due to trauma or to intra-abdominal, vascular, or neurosurgical emergencies. The time from onset of the cause of the emergency to operative treatment is directly related to complications and death. Delay to accurate diagnosis is common and may be masked by delirium. Sepsis, pain hypotension, and metabolic disorders may all trigger delirium. Resuscitation and optimization should be concurrent with operative management. Important factors considered include the possible cause of a fall (cardiac/neurologic), likelihood of severe hypovolaemia, electrolyte disorders, and ischaemic vascular disease (occlusive and embolic). Emergency laparotomy is reviewed with the possible reasons behind the appalling outcome data, such as delayed diagnosis and poor nutritional state.
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12

Tadayon, Masoud. Computer simulation of signalized highway intersections: Vehicular and pedestrian movements at signal controlled intersections are modelled and delay minimizing and cycle time optimization procedures developed by computer simulation for different signal control strategies. Bradford, 1985.

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13

Dodds, Chris, Chandra M. Kumar und Frédérique Servin. Day-case anaesthesia in the elderly. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198735571.003.0005.

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Successful outcome from day surgery depends on good preoperative preparation, education of patients, day-surgery pathways, informed decisions regarding planned procedures, and postoperative care. Day surgery is widely accepted as the default position for the vast majority of patients requiring surgery, with inpatient stay chosen only by exclusion. Day surgery remains a good choice in the elderly, subject to appropriate home care after surgery. Patients should be assessed sufficiently ahead of the surgery to allow preparation, management of associated chronic diseases, and optimization. General anaesthesia may be associated with higher incidence of postoperative cognitive dysfunction, and it should be avoided as much as possible. Regional anaesthesia is the preferred choice when applicable because it provides good postoperative analgesia. Spinal anaesthesia is useful, but it can be associated with delayed discharge. A multimodal approach to pain relief and management of postoperative nausea and vomiting (PONV) are essential because inadequate management can significantly delay discharge.
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14

Grisoli, Dominique, und Didier Raoult. Prevention and treatment of endocarditis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0161.

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Initially always lethal, the prognosis of infective endocarditis (IE) has been revolutionized by antibacterial therapy and valve surgery. Nevertheless, it remains one of the deadliest infectious diseases, with ≥30% of patients dying within a year of diagnosis. Its incidence has also remained stable at 25–50 cases per million per year, and results predominantly from a combination of bacteraemia and a predisposing cardiac condition, including endocardial lesions and/or intracardiac foreign material. While antibiotic prophylaxis is recommended by various learned societies to cover healthcare procedures with the potential of causing bacteraemia in at-risk patients, there is no evidence to support this strategy. Even though the benefits are hypothetical, national guidelines should still be followed to avoid medico-legal issues. General preventive measures, such as education of clinicians and at-risk patients appear to be more crucial. Invasive procedures, especially intravenous catheterization, should be kept to the minimum possible. The severity of IE mandates a multidisciplinary and standardized approach to treatment, with involvement of dedicated surgeons within specialist centres. Standardized antibiotic protocols have produced dramatic reductions in hospital and 1-year mortality in reference centres. Most deaths now result from complications that constitute definite surgical indications, so optimization of surgical management and avoidance of delay will clearly improve prognosis. This disease has now entered an ‘early surgery’ era, with a more aggressive surgical approach showing promising results. Conditions such as septic shock, sudden death, and vancomycin-resistant staphylococcal endocarditis still constitute therapeutic and research challenges, and justify an important role for specialist centres.
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15

Karatasakis, G., und G. D. Athanassopoulos. Cardiomyopathies. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199599639.003.0019.

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Echocardiography is a key diagnostic method in the management of patients with cardiomyopathies.The main echocardiographic findings of hypertrophic cardiomyopathy are asymmetric hypertrophy of the septum, increased echogenicity of the myocardium, systolic anterior motion, turbulent left ventricular (LV) outflow tract blood flow, intracavitary gradient of dynamic nature, mid-systolic closure of the aortic valve and mitral regurgitation. The degree of hypertrophy and the magnitude of the obstruction have prognostic meaning. Echocardiography plays a fundamental role not only in diagnostic process, but also in management of patients, prognostic stratification, and evaluation of therapeutic intervention effects.In idiopathic dilated cardiomyopathy, echocardiography reveals dilation and impaired contraction of the LV or both ventricles. The biplane Simpson’s method incorporates much of the shape of the LV in calculation of volume; currently, three-dimensional echocardiography accurately evaluates LV volumes. Deformation parameters might be used for detection of early ventricular involvement. Stress echocardiography using dobutamine or dipyridamole may contribute to risk stratification, evaluating contractile reserve and left anterior descending flow reserve. LV dyssynchrony assessment is challenging and in patients with biventricular pacing already applied, optimization of atrio-interventricular delays should be done. Specific characteristics of right ventricular dysplasia and isolated LV non-compaction can be recognized, resulting in an increasing frequency of their prevalence. Rare forms of cardiomyopathy related with neuromuscular disorders can be studied at an earlier stage of ventricular involvement.Restrictive and infiltrative cardiomyopathies are characterized by an increase in ventricular stiffness with ensuing diastolic dysfunction and heart failure. A variety of entities may produce this pathological disturbance with amyloidosis being the most prevalent. Storage diseases (Fabry, Gaucher, Hurler) are currently treatable and early detection of ventricular involvement is of paramount importance for successful treatment. Traditional differentiation between constrictive pericarditis (surgically manageable) and the rare cases of restrictive cardiomyopathy should be properly performed.
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