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Thematische Bibliographien / D Activity / Zeitschriftenartikel

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Zeitschriftenartikel zum Thema „D Activity“

Autor: Grafiati

Veröffentlicht am 24. Juni 2021

Zuletzt aktualisiert am 4. Februar 2022

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1

Garcia-Saavedra, Yair, Antonio Rivera, Fernando Hernandez-Aladana, Omar Romero-Arenas, Primo Sanchez-Morales und Silvia Giono-Cerezo. „Carbofuran, Malathion and 2,4-D Degradation by Bacterial Activity“. Journal of Pure and Applied Microbiology 12, Nr. 3 (30.09.2018): 1331–35. http://dx.doi.org/10.22207/jpam.12.3.35.

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2

Kumar, Pradeep, Kriti Arora, John R. Lloyd, Ill Y. Lee, Vinod Nair, Elizabeth Fischer, Helena I. M. Boshoff und Clifton E. Barry. „Meropenem inhibits D,D-carboxypeptidase activity inMycobacterium tuberculosis“. Molecular Microbiology 86, Nr. 2 (28.08.2012): 367–81. http://dx.doi.org/10.1111/j.1365-2958.2012.08199.x.

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3

Hurley, M. J., L. B. Larsen, A. L. Kelly und P. L. H. McSweeney. „Cathepsin D activity in quarg“. International Dairy Journal 10, Nr. 7 (Januar 2000): 453–58. http://dx.doi.org/10.1016/s0958-6946(00)00062-5.

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4

Simpson, T. D. „Phospholipase D activity in hexane“. Journal of the American Oil Chemists’ Society 68, Nr. 3 (März 1991): 176–78. http://dx.doi.org/10.1007/bf02657764.

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5

Morris, Andrew J., Michael A. Frohman und JoAnne Engebrecht. „Measurement of Phospholipase D Activity“. Analytical Biochemistry 252, Nr. 1 (Oktober 1997): 1–9. http://dx.doi.org/10.1006/abio.1997.2299.

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6

Lin, Ching-Yuang, und Betau Hwang. „Zinc can activate cellular acidic α-d-glucosidase activity“. Biochemical Genetics 26, Nr. 5-6 (Juni 1988): 323–29. http://dx.doi.org/10.1007/bf02401786.

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7

Cruz, M. „Impulsive Activity“. Science 338, Nr. 6113 (13.12.2012): 1397. http://dx.doi.org/10.1126/science.338.6113.1397-d.

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8

Hrmova, Maria, Andrew J. Harvey, Jun Wang, Neil J. Shirley, Graham P. Jones, Bruce A. Stone, Peter B. H⊘j und Geoffrey B. Fincher. „Barley β-D-Glucan Exohydrolases with β-D-Glucosidase Activity“. Journal of Biological Chemistry 271, Nr. 9 (März 1996): 5277–86. http://dx.doi.org/10.1074/jbc.271.9.5277.

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9

Cheng, Hao, und Gangliang Huang. „Synthesis and Activity of Epothilone D“. Current Drug Targets 19, Nr. 15 (26.10.2018): 1866–70. http://dx.doi.org/10.2174/1389450119666180803122118.

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10

Kokubo, Mamoru, Hiroo Kawaziri, Syulohi Kikukchi, Sakae Iwagami und Susumu Shoin. „Antitumor activity of d-morphinan derivatives“. Japanese Journal of Pharmacology 40 (1986): 270. http://dx.doi.org/10.1016/s0021-5198(19)59556-7.

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11

Ella, Krishna M., Chen Qi, Anthony F. McNair, Jin-Hyouk Park, April E. Wisehart-Johnson und Kathryn E. Meier. „Phospholipase D Activity in PC12 Cells“. Journal of Biological Chemistry 272, Nr. 20 (16.05.1997): 12909–12. http://dx.doi.org/10.1074/jbc.272.20.12909.

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12

Pawłowska-Góral, Katarzyna, Jarosław Markowski, Piotr Wardas, Ewa Kurzeja und Małgorzata Witkowska. „Cathepsin D activity in nasal polyps“. Clinical Biochemistry 45, Nr. 15 (Oktober 2012): 1251–53. http://dx.doi.org/10.1016/j.clinbiochem.2012.05.015.

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13

Szekeres-Barthó, Júlia, Eva Miko, Tímea Balassa und Vittorio Unfer. „462: Immunomodulatory activity of Vitamin D“. American Journal of Obstetrics and Gynecology 222, Nr. 1 (Januar 2020): S303. http://dx.doi.org/10.1016/j.ajog.2019.11.478.

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14

Stern, Peter. „Neuronal activity asleep“. Science 372, Nr. 6547 (10.06.2021): 1163.4–1164. http://dx.doi.org/10.1126/science.372.6547.1163-d.

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15

Zhuo, Kelei, Jianji Wang und Hanqing Wang. „Activity coefficients for NaCl–monosaccharide (d-glucose, d-galactose, d-xylose, d-arabinose)–water systems at 298.15 K“. Carbohydrate Research 325, Nr. 1 (März 2000): 46–55. http://dx.doi.org/10.1016/s0008-6215(99)00298-0.

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16

Mast, Alan E., Jason E. Stadanlick, J. Marcus Lockett und Dennis J. Dietzen. „Solvent/Detergent-Treated Plasma Has Decreased Antitrypsin Activity and Absent Antiplasmin Activity“. Blood 94, Nr. 11 (01.12.1999): 3922–27. http://dx.doi.org/10.1182/blood.v94.11.3922.

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Abstract Solvent/detergent (S/D)-treated plasma is currently marketed by the American Red Cross as a virally inactivated alternative to fresh-frozen plasma (FFP). The serpin-type serine proteinase inhibitors have a flexible reactive site loop (RSL) that can convert from the active conformation to the inactive latent or polymerized conformations when exposed to heat and/or detergents. We have compared the conformational stability and inhibitory activity of 3 plasma serpins—antithrombin, antitrypsin, and antiplasmin—in S/D plasma and FFP. In S/D plasma, virtually 100% of the antiplasmin and approximately 50% of the antitrypsin are in either the latent or polymerized conformation and lack inhibitory activity, while in FFP only the active conformation is present. Interestingly, antithrombin is not affected by S/D treatment and remains fully active. These data demonstrate that S/D plasma is not simply a virally inactivated equivalent of FFP. The lack of antiplasmin activity and decreased antitrypsin activity in S/D plasma suggest that it may not be as effective as FFP for the treatment of bleeding in patients with systemic activation of proteolytic cascades, such as disseminated intravascular coagulation and sepsis, acquired fibrinolytic states, and large-volume transfusion. Although there has been extensive use of S/D plasma in several European countries with no reports of adverse effects, clinical studies directly comparing the efficacy of these 2 plasma products are needed to directly evaluate the relative therapeutic efficacy of FFP and S/D plasma for the treatment of these diseases.

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17

Mast, Alan E., Jason E. Stadanlick, J. Marcus Lockett und Dennis J. Dietzen. „Solvent/Detergent-Treated Plasma Has Decreased Antitrypsin Activity and Absent Antiplasmin Activity“. Blood 94, Nr. 11 (01.12.1999): 3922–27. http://dx.doi.org/10.1182/blood.v94.11.3922.423k33_3922_3927.

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Solvent/detergent (S/D)-treated plasma is currently marketed by the American Red Cross as a virally inactivated alternative to fresh-frozen plasma (FFP). The serpin-type serine proteinase inhibitors have a flexible reactive site loop (RSL) that can convert from the active conformation to the inactive latent or polymerized conformations when exposed to heat and/or detergents. We have compared the conformational stability and inhibitory activity of 3 plasma serpins—antithrombin, antitrypsin, and antiplasmin—in S/D plasma and FFP. In S/D plasma, virtually 100% of the antiplasmin and approximately 50% of the antitrypsin are in either the latent or polymerized conformation and lack inhibitory activity, while in FFP only the active conformation is present. Interestingly, antithrombin is not affected by S/D treatment and remains fully active. These data demonstrate that S/D plasma is not simply a virally inactivated equivalent of FFP. The lack of antiplasmin activity and decreased antitrypsin activity in S/D plasma suggest that it may not be as effective as FFP for the treatment of bleeding in patients with systemic activation of proteolytic cascades, such as disseminated intravascular coagulation and sepsis, acquired fibrinolytic states, and large-volume transfusion. Although there has been extensive use of S/D plasma in several European countries with no reports of adverse effects, clinical studies directly comparing the efficacy of these 2 plasma products are needed to directly evaluate the relative therapeutic efficacy of FFP and S/D plasma for the treatment of these diseases.

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18

Matthews, Sharon A., Enrique Rozengurt und Doreen Cantrell. „Protein Kinase D“. Journal of Experimental Medicine 191, Nr. 12 (12.06.2000): 2075–82. http://dx.doi.org/10.1084/jem.191.12.2075.

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Protein kinase Cs (PKCs) are activated by antigen receptors in lymphocytes, but little is known about proximal targets for PKCs in antigen receptor–mediated responses. In this report, we define a role for diacylglycerol-regulated PKC isoforms in controlling the activity of the serine/threonine kinase protein kinase D (PKD; also known as PKCμ) in T cells, B cells, and mast cells. Antigen receptor activation of PKD is a rapid and sustained response that can be seen in T cells activated via the T cell antigen receptor, B cells activated via the B cell antigen receptor, and in mast cells triggered via the high-affinity receptor for IgE (FcεR1). Herein, we show that antigen receptor activation of PKD requires the activity of classical/novel PKCs. Moreover, PKC activity is sufficient to bypass the requirement for antigen receptor signals in the induction of PKD activity. These biochemical and genetic studies establish a role for antigen receptor–regulated PKC enzymes in the control of PKD activity. Regulation of PKD activity through upstream PKCs reveals a signaling network that exists between different members of the PKC superfamily of kinases that can operate to amplify and disseminate antigen receptor signals generated at the plasma membrane.

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19

SUGIHARA, Akio, Yuji SHIMADA und Yoshio TOMINAGA. „3-D Structure and Activity of Lipase“. Journal of Japan Oil Chemists' Society 44, Nr. 10 (1995): 713–20. http://dx.doi.org/10.5650/jos1956.44.713.

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20

Gruber-Bzura, Beata M. „Anticancer activity of vitamin D – molecular mechanisms“. Postępy Higieny i Medycyny Doświadczalnej 74 (09.06.2020): 191–97. http://dx.doi.org/10.5604/01.3001.0014.1882.

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A large number of studies have pointed to the relations between blood levels of 25-hydroxy vitamin D with cancer incidence and survival. The phenomenon of the multidirectional activity of vitamin D is possibly due to the presence of VDR in most nonskeletal human cells, including cancer cells. A wide range of the genes regulated by VDR are related with cell proliferation, apoptosis, differentiation, angiogenesis and metastasis. In some preclinical studies, colon, lung and BC have all demonstrated downregulation of VDR expression as compared to normal cells, and well-differentiated tumors have shown more VDR expression when compared to their poorly differentiated counterparts. Generally, higher tumor VDR expression has been noted as correlating with better prognosis in cancer patients. However, vitamin D pathway genetic polymorphisms also may influence cancer risk. VDR polymorphisms have received the most attention, but this influence has also been observed in genes related to vitamin D metabolism or signalling, such as: CYP27B1, CYP24A1, VDBP or RXRA. Even though the associations between most of them and cancers were not significant, some studies show that VDR polymorphisms may be a better or poor prognostic factor to assess the risk of cancer. The aim of this paper was to present the molecular pathways affected by vitamin D, which are included in carcinogenesis. The literature survey comprised of research compiled from mostly the last five years and it proves vitamin D as the most phenomenal among other vitamins.

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21

Picotto, Gabriela, Ana C. Liaudat, Luciana Bohl und Nori Tolosa de Talamoni. „Molecular Aspects of Vitamin D Anticancer Activity“. Cancer Investigation 30, Nr. 8 (10.09.2012): 604–14. http://dx.doi.org/10.3109/07357907.2012.721039.

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22

Wang, Yuan-Chuen, Hsing-Wen Hsu und Wen-Ling Liao. „Antibacterial activity of Melastoma candidum D. Don“. LWT - Food Science and Technology 41, Nr. 10 (Dezember 2008): 1793–98. http://dx.doi.org/10.1016/j.lwt.2008.02.005.

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23

Boni, R., R. Santillo, G. Macchia, P. Spinelli, G. Ferrandino und A. D’Aniello. „d-Aspartate and reproductive activity in sheep“. Theriogenology 65, Nr. 7 (April 2006): 1265–78. http://dx.doi.org/10.1016/j.theriogenology.2005.07.019.

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24

Rasmussen, Morten, und Leif Rasmussen. „Phospholipase D in Tetrahymena: activity and significance“. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 124, Nr. 4 (Dezember 1999): 467–73. http://dx.doi.org/10.1016/s0305-0491(99)00144-3.

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25

Wolosker, H. „D-Serine Regulation of NMDA Receptor Activity“. Science's STKE 2006, Nr. 356 (04.10.2006): pe41. http://dx.doi.org/10.1126/stke.3562006pe41.

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26

Kusner, David J., James A. Barton, Kuo-Kuang Wen, Xuemin Wang, Peter A. Rubenstein und Shankar S. Iyer. „Regulation of Phospholipase D Activity by Actin“. Journal of Biological Chemistry 277, Nr. 52 (17.10.2002): 50683–92. http://dx.doi.org/10.1074/jbc.m209221200.

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27

URBANIAK, S., und G. STEWART. „ADCC activity of monoclonal anti-D antibodies“. Revue Francaise de Transfusion et Immuno-hématologie 31, Nr. 2 (April 1988): 237–43. http://dx.doi.org/10.1016/s0338-4535(88)80109-0.

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28

Armstrong-Fisher, S. S., I. Gray, D. H. Todd, A. Forrest und S. J. Urbaniak. „ADCC activity of monoclonal anti-D antibodies“. Transfusion Clinique et Biologique 3, Nr. 6 (Januar 1996): 475–77. http://dx.doi.org/10.1016/s1246-7820(96)80066-8.

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29

Birrell, F., und R. M. Francis. „Invited Commentary: Physical Activity and Vitamin D“. American Journal of Epidemiology 168, Nr. 6 (15.07.2008): 587–89. http://dx.doi.org/10.1093/aje/kwn161.

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30

Lukowski, Sandra, Marie-Christine Lecomte, Jean-Paul Mira, Philippe Marin, Huguette Gautero, Françoise Russo-Marie und Blandine Geny. „Inhibition of Phospholipase D Activity by Fodrin“. Journal of Biological Chemistry 271, Nr. 39 (27.09.1996): 24164–71. http://dx.doi.org/10.1074/jbc.271.39.24164.

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31

Gittleman, Maury, und Edward N. Wolff. „R&D ACTIVITY AND ECONOMIC DEVELOPMENT“. International Journal of Public Administration 24, Nr. 10 (31.07.2001): 1061–81. http://dx.doi.org/10.1081/pad-100105102.

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32

&NA;. „D-62 Thematic Poster - Physical Activity Interventions“. Medicine & Science in Sports & Exercise 46 (Mai 2014): 564–66. http://dx.doi.org/10.1249/01.mss.0000451215.50673.70.

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33

Merchan, Jaime R., Krisztina Kovács, Jaclyn W. Railsback, Metin Kurtoglu, Yuqi Jing, Yolanda Piña, Ningguo Gao, Timothy G. Murray, Mark A. Lehrman und Theodore J. Lampidis. „Antiangiogenic Activity of 2-Deoxy-D-Glucose“. PLoS ONE 5, Nr. 10 (27.10.2010): e13699. http://dx.doi.org/10.1371/journal.pone.0013699.

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34

Acs, Zoltan J., David B. Audretsch und Maryann P. Feldman. „R&D spillovers and innovative activity“. Managerial and Decision Economics 15, Nr. 2 (März 1994): 131–38. http://dx.doi.org/10.1002/mde.4090150205.

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35

KOVÁCS, P., G. CSABA, S. NAKASHIMA und Y. NOZAWA. „Phospholipase D Activity in theTetrahymena pyriformis GL“. Cell Biochemistry and Function 15, Nr. 1 (März 1997): 53–60. http://dx.doi.org/10.1002/(sici)1099-0844(199703)15:1<53::aid-cbf720>3.0.co;2-f.

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36

Vlasova, A. L., M. E. Preobrazhenskaya und N. D. Khoroshko. „Neutral ?-D-mannosidase activity in human granulocytes“. Bulletin of Experimental Biology and Medicine 111, Nr. 3 (März 1991): 309–12. http://dx.doi.org/10.1007/bf00840883.

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37

Buckow, Roman, Binh Quong Truong und Cornelis Versteeg. „Bovine cathepsin D activity under high pressure“. Food Chemistry 120, Nr. 2 (Mai 2010): 474–81. http://dx.doi.org/10.1016/j.foodchem.2009.10.040.

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38

Anderson, Paul H. „Vitamin D Activity and Metabolism in Bone“. Current Osteoporosis Reports 15, Nr. 5 (14.08.2017): 443–49. http://dx.doi.org/10.1007/s11914-017-0394-8.

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39

Mansfeld, Johanna, und Renate Ulbrich-Hofmann. „Modulation of phospholipase D activity in vitro“. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1791, Nr. 9 (September 2009): 913–26. http://dx.doi.org/10.1016/j.bbalip.2009.03.003.

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40

Chemnitius, J. M., K. H. Haselmeyer, H. Kreuzer und R. Zech. „D/L-sotalol exerts indirect parasympathomimetic activity“. Pharmacological Research 31 (Januar 1995): 73. http://dx.doi.org/10.1016/1043-6618(95)86552-7.

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41

Warner, M., und A. Tenenhouse. „Regulation of renal vitamin D hydroxylase activity in vitamin D deficient rats“. Canadian Journal of Physiology and Pharmacology 63, Nr. 8 (01.08.1985): 978–82. http://dx.doi.org/10.1139/y85-161.

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The regulation of renal mitochondrial 1-hydroxylase activity in chronic vitamin D deficiency was studied in male rats. These rats were born of mothers who had been raised from weaning (21 days) on a vitamin D deficient diet and who had no detectable serum 1,25-dihydroxycholecalciferol (1,25-(OH)2D) at the time their offspring were weaned (28 days). In the pups, renal mitochondrial 1-hydroxylase activity was undetectable before the 3rd week of life even though the animals were severely hypocalcemic from birth. The 1-hydroxylase activity first became detectable at 26 days of age, rapidly reached a maximum at day 34, then decreased to become undetectable again by 65 days. Throughout this time serum calcium concentration was <5.0 mg/dL and serum parathyroid hormone (PTH) concentration, measured by a midmolecule radioimmunoassay, was two-to five-fold greater than that found in vitamin D replete rats. 1-Hydroxylase activity could be restored in the +65-day-old animals by administration of a single dose of 2.5 μg vitamin D3. Enzyme activity was detected within 24 h, was maximal at 72 h, and returned to undetectable levels by 96 h after administration of the vitamin. Serum 1,25-(OH)2D which was undetectable before administration of the vitamin D3, was 108 and 458 pg/mL at 16 and 40 h, respectively, after the injection. The serum concentration of this metabolite then decreased progressively to 80 pg/mL by 6 days. 24-Hydroxylase activity first became detectable 48 h after vitamin D administration, increased to a maximum at 96 h, and thereafter decreased to become undetectable by 7 days. The urinary excretion of phosphate and cyclic AMP was 10% of control values between 65 and 90 days of age. These values became normal 4 days after a single dose of 2.5 μg vitamin D3. From these data it is concluded that there are two distinct levels of regulation of 1-hydroxylase activity: a vitamin D independent induction of the activity at the time of weaning that is transient and is not associated with any detectable 24-hydroxylase activity; and the second is a vitamin D dependent induction of enzyme activity seen in animals which prior to administration of the vitamin manifest the characteristics of PTH resistance and have no detectable renal hydroxylase activity. The mechanisms of these effects remain to be determined.

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42

Yamada, Ryohei, Hisae Nagasaki, Yoko Nagata, Yasuo Wakabayashi und Akio Iwashima. „Administration of D-aspartate increases D-aspartate oxidase activity in mouse liver“. Biochimica et Biophysica Acta (BBA) - General Subjects 990, Nr. 3 (März 1989): 325–28. http://dx.doi.org/10.1016/s0304-4165(89)80053-4.

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43

Baute, Marie-Antoinette, Robert Baute und Gérard Deffieux. „Fungal enzymic activity degrading 1,4-α-d-glucans to. 1,5-d-anhydrofructose“. Phytochemistry 27, Nr. 11 (Januar 1988): 3401–3. http://dx.doi.org/10.1016/0031-9422(88)80738-6.

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44

Yang, Hui-Rong, Lian-Hong Chen und Ying-Jie Zeng. „Structure, Antioxidant Activity and In Vitro Hypoglycemic Activity of a Polysaccharide Purified from Tricholoma matsutake“. Foods 10, Nr. 9 (14.09.2021): 2184. http://dx.doi.org/10.3390/foods10092184.

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The structure, antioxidant activity and hypoglycemic activity in vitro of a novel homogeneous polysaccharide from Tricholoma matsutake (Tmp) were investigated. Structural features suggested that Tmp was consisted of arabinose (Ara), mannose (Man), glucose (Glc) and galactose (Gal) with a molar ratio of 1.9:13.6:42.7:28.3, respectively, with a molecular weight of 72.14 kDa. The structural chain of Tmp was confirmed to contain →2,5)-α-l-Arabinofuranose (Araf)-(1→, →3,5)-α-l-Araf-(1→, β-d-Glucopyranose (Glcp)-(1→, α-d-Mannopyranose (Manp)-(1→, α-d-Galacopyranose (Galp)-(1→, →4)-β-d-Galp-(1→, →3)-β-d-Glcp-(1→, →3)-α-d-Manp-(1→, →6)-3-O-Methyl (Me)-α-d-Manp-(1→, →6)-α-d-Galp-(1→, →3,6)-β-d-Glcp-(1→, →6)-α-d-Manp-(1→ residues. Furthermore, Tmp possessed strong antioxidant activity and showed the strong inhibitory effect on α-glucosidase and α-amylase activities. Then, a further evaluation found that there was a dramatic improvement in the glucose consumption, glycogen synthesis and the activities of pyruvate kinase and hexokinase when the insulin-resistant-human hepatoma cell line (IR-HepG2) was treated with Tmp. The above results indicated that Tmp had good hypoglycemic activity and also exhibited great potentials in in terms of dealing with type 2 diabetes mellitus.

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45

Lavine, Marc S. „Eye can see neural activity“. Science 360, Nr. 6396 (28.06.2018): 1416.4–1416. http://dx.doi.org/10.1126/science.360.6396.1416-d.

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46

Rowlands, Alex V. „Physical Activity, Inactivity, and Health“. Pediatric Exercise Science 27, Nr. 1 (Februar 2015): 21–25. http://dx.doi.org/10.1123/pes.2015-0030.

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Background:The total activity volume performed is an overall measure that takes into account the frequency, intensity, and duration of activities performed. The importance of considering total activity volume is shown by recent studies indicating that light physical activity (LPA) and intermittent moderate-to-vigorous physical activity (MVPA) have health benefits. Accelerometer-derived total activity counts (TAC) per day from a waist-worn accelerometer can serve as a proxy for an individual’s total activity volume. The purpose of this study was to develop age- and gender-specific percentiles for daily TAC, minutes of MVPA, and minutes of LPA in U.S. youth ages 6-19 y.Methods:Data from the 2003-2006 NHANES waist-worn accelerometer component were used in this analysis. The sample was composed of youth aged 6-19 years with at least 4 d of ≥10 hr of accelerometer wear time (N = 3698). MVPA was defined using age specific cutpoints as the total number of minutes at ≥4 metabolic equivalents (METs) for youth 6-17 y or minutes with ≥2020 counts for youth 18-19 y. LPA was defined as the total number of minutes between 100 counts and the MVPA threshold. TAC/d, MVPA, and LPA were averaged across all valid days.Results:For males in the 50th percentile, the median activity level was 441,431 TAC/d, with 53 min/d of MVPA and 368 min/d of LPA. The median level of activity for females was 234,322 TAC/d, with 32 min/d of MVPA and 355 min/d of LPA.Conclusion:Population referenced TAC/d percentiles for U.S. youth ages 6-19 y provide a novel means of characterizing the total activity volume performed by children and adolescents.

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Taouis, M., D. Deville de Periere, D. Hillaire-Buys, M. Derouet, R. Gross, J. Simon und G. Ribes. „Biological activity of immunoreactive insulin-like activity extracted from rat submandibular gland“. American Journal of Physiology-Endocrinology and Metabolism 269, Nr. 2 (01.08.1995): E277—E282. http://dx.doi.org/10.1152/ajpendo.1995.269.2.e277.

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Earlier studies indicate the presence of an insulin-like immunoreactivity (ILI) in rat submandibular salivary glands (SSG). Previous observations also showed that streptozotocin (STZ)-induced diabetes was accompanied by an increase in SSG ILI concentrations. In the present work we studied the effect of SSG ILI from normal and STZ diabetic rats (ILI-N and ILI-D, respectively) on insulin receptor binding and function in LMH cell line. ILI-N and ILI-D inhibited 125I-insulin binding to intact cells and wheat germ agglutinin (WGA)-purified insulin receptors with a high affinity. Furthermore, ILI-N and ILI-D activated, although weakly, the beta-subunit autophosphorylation of solubilized and WGA-purified insulin receptors. An ATP hydrolytic activity was present in ILI-N and, to a greater extent, in ILI-D extracts, which can at least in part explain their low potency for activating autophosphorylation and kinase activity of insulin receptors in vitro. However, after ILI treatment of intact cells and immunoprecipitation of insulin receptors, ILI induced a dose-dependent tyrosine phosphorylation of the insulin receptor beta-subunit. Finally, ILI-N and ILI-D stimulated amino acid uptake and lipogenesis in LMH cells. These findings suggest that SSG ILI is biologically active and can participate in metabolic regulations.

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NIIDA, Hiroshi. „R&D Activity and Development of Multilateral Management“. Input-Output Analysis 3, Nr. 2 (1992): 66–75. http://dx.doi.org/10.11107/papaios.3.66.

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Moriishi, K., B. Syuto, K. Oguma und M. Saito. „Separation of toxic activity and ADP-ribosylation activity of botulinum neurotoxin D.“ Journal of Biological Chemistry 265, Nr. 27 (September 1990): 16614–16. http://dx.doi.org/10.1016/s0021-9258(17)46266-1.

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Al-muamin, Thanaa, Naeemah Al-lami, Suroor Rahman und Rana Ali. „Synthesis, Characterization and Antimicrobial Activity of New Nucleoside Analogues from Benzotriazole“. Chemistry & Chemical Technology 10, Nr. 3 (15.09.2016): 271–78. http://dx.doi.org/10.23939/chcht10.03.271.

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Novel derivatives of 1-(´1, ´3, ´4, ´6-tetra benzoyl-β-D-fructofuranosyl)-1H- benzotriazole and 1-(´1, ´3, ´4, ´6-tetra benzoyl-β-D-fructofuranosyl)-1H-benzotriazole carrying Schiff bases moiety were synthesised and fully characterised. The protection of D-fructose using benzoyl chloride was synthesized, followed by nucleophilic addition/elimination between benzotriazole and chloroacetyl chloride to give 1-(1- chloroacetyl)-1H-benzotriazole. The next step was condensation reaction of protected fructose and 1-(1-chloroacetyl)-1H-benzotriazole producing a new nucleoside analogue. The novel nucleoside analogues underwent a second condensation reaction with different aromatic and aliphatic amines to provide new Schiff bases. The prepared analogues were characterised by FT-IR, 1H NMR, 13C NMR, HRMS(EI+) spectra. These analogues were tested against different bacteria to evaluate them as antimicrobial agents.

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