Dissertationen: „Cytogenetics“

1

Fantes, Judith Ann. „Molecular cytogenetics of 11p“. Thesis, Open University, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388443.

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2

Marshall, Jillian Annette. „Molecular cytogenetics of Lycopersicon Mill“. Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310839.

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3

Slater, Sarah. „The role of cytogenetics in leukaemia“. Thesis, Queen Mary, University of London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398923.

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4

Xin, Mao. „Molecular cytogenetics of primary cutaneous lymphomas“. Thesis, King's College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408664.

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5

Johansson, Soller Maria. „Cytogenetic studies of lung tumors“. Lund : Dept. of Clinical Genetics, University of Lund, 1994. http://catalog.hathitrust.org/api/volumes/oclc/39068855.html.

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6

Sun, Li. „Molecular cytogenetics of oral squamous cell carcinoma“. Click to view the E-thesis via HKUTO, 2002. http://sunzi.lib.hku.hk/HKUTO/record/B38627887.

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7

Loveday, Ruth Louise. „Molecular cytogenetics of breast cancer : clinical perspectives“. Thesis, University of Hull, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322556.

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8

鄺沃林 und Yok-lam Kwong. „Cytogenetics and molecular genetics of haematological disorders“. Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1995. http://hub.hku.hk/bib/B31981550.

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9

Sun, Li, und 孫莉. „Molecular cytogenetics of oral squamous cell carcinoma“. Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B36544267.

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10

Kwong, Yok-lam. „Cytogenetics and molecular genetics of haematological disorders“. Hong Kong : University of Hong Kong, 1995. http://sunzi.lib.hku.hk/hkuto/record.jsp?B14036423.

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11

Blegen, Harald. „Genomic instability and tumor progression : a cytochemical, molecular biological and cytogenetic study of human tissue from uterine cervix, colon, breast and ovary /“. Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3464-9/.

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12

Engelen, Johan Joseph Maria. „The application of micro-fish in clinical cytogenetics“. Maastricht : Maastricht : Universiteit Maastricht ; University Library, Maastricht University [Host], 1998. http://arno.unimaas.nl/show.cgi?fid=6055.

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13

Oostenbrugge, Robert Jan van. „Interphase cytogenetics in the cytodiagnosis of leptomeningeal metastases“. [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Maastricht University [Host], 1999. http://arno.unimaas.nl/show.cgi?fid=6838.

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14

All-Ericsson, Charlotta. „Uveal melanoma : cytogenetics, molecular biology and tumor immunology /“. Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-278-7.

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15

Anamthawat-Jonsson, Kesara Margret. „Molecular cytogenetics and nuclear organization in the Triticeae“. Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239571.

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16

Hu, Liang, und 胡亮. „Application of molecular cytogenetics techniques in cancer research“. Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B3014890X.

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17

Smith, Geoffrey W. „Molecular genetic techniques as an aid to cytogenetics“. Thesis, Queen's University Belfast, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301000.

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18

Shuib, Salwati. „Molecular cytogenetics and genetic characterisation of chromosomal rearrangements“. Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/1339/.

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In this thesis I report three related studies that utilise state-of-the-art technologies to investigate germline and somatic chromosomal rearrangements in humans. Firstly, 16 patients with cytogenetically detectable deletions of 3p25-p26 were analysed with high density single nucleotide polymorphism (SNP) microarrays; Affymetrix 250K SNP microarrays (n=14) and Affymetrix SNP6.0 (n=2). Assuming complete penetrance, a critical region for congenitalheart disease (CHD) susceptibility gene was refined to approximately 200 kb and a candidate critical region for mental retardation was mapped to ~1 Mb interval containing SRGAP3. Secondly, I used SNP microarray and molecular cytogenetic studies to characterize chromosome 11p15 in 8 patients with the imprinting disorder Beckwith-Wiedemann syndrome (BWS). In addition to characterising 11p duplications in three patients, the breakpoints in two patients with balanced rearrangements were mapped to two distinct regions. Thirdly, I used high resolution SNP arrays (Affymetrix 250K Sty1 and 6.0 arrays) to identify copy number changes in renal cell carcinoma (RCC) primary tumours (n=81) and cell lines (n=23). Copy number changes most frequently involved large segments (>10Mb) and loss of 3p and gain of 5q were the most common copy number changes. A comparison of copy number changes in RCC cell lines and inherited and sporadic primary tumours was made.

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19

Kulharya, Anita S. (Anita Singh). „Cytogenetics of chromosome 22 and its clinical relevance“. Thesis, University of North Texas, 1990. https://digital.library.unt.edu/ark:/67531/metadc798385/.

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This investigation reorganizes and identifies chromosomal anomalies and delineates the associated clinical findings. The present investigation involved 37 individuals with anomalies of chromosome 22. The clinical profile with the corresponding cytogenetic anomalies was studied.

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20

Turner, Jill Yeatman. „Cytogenetics of Delphinium (Ranunculaceae) Species Native to Oregon“. PDXScholar, 1992. https://pdxscholar.library.pdx.edu/open_access_etds/4566.

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Evidence of hybridization, known to occur in the genus Delphinium (Ranunculaceae ), has recently been discovered among certain Delphinium species native to Oregon. This issue was investigated by cytogenetic analysis of four native species of Oregon, D. trolliifolium, D. menziesii, D. pavonaceum and D.leucophaeum, and an unidentified purple delphinium, which is possibly a hybrid. Although many species in this genus are karyotypically similar, any variations found among the karyotypes of these Oregon species might be used to identify parental chromosomes in the purple delphinium (proposed hybrid). Meiotic analysis was used to detect structurally heterozygous homologues that are not observable in somatic cells. Reproductive success, an extension of meiosis, was also investigated. In lieu of the endangered status of two of these Oregon species, attempts were made to develop a system for obtaining dividing cells for cytogenetic study that has negligible impact on plant populations. Apical meristems of seed radicles from the Oregon species and the proposed hybrid were stained with orcein. The metaphase chromosomes were photographed and measured, and chromosome arm ratios and relative lengths calculated. Analyses of variance and multiple comparison tests were run to determine if any significant differences in chromosome measurement exist among these Oregon delphiniums. Satellites and other morphological features were noted. Anther contents were also stained with orcein and microsporogenesis examined. Pollen viability and percent seed germination was determined for each of the species and the proposed hybrid. Callus and organized tissue that developed in vitro were stained with orcein and the mitotic cells examined. The unhanded karyotypes of the Oregon species and the proposed hybrid are similar in number, size and shape; major structural differences between species, if present, are not observable at this level of chromosome resolution. No markers for the identification of parental chromosomes in the proposed hybrid are available with this staining technique. However, statistical analysis of mean chromosome arm ratio and length indicates that D. menziesii, D. pavonaceum and D.leucophaeum are more closely related to one another than they are to D. trolliifolium and the proposed hybrid, and vice versa. D. trolliifolium is therefore a candidate parent species of the proposed hybrid whereas the other three species are likely not candidates. Karyotypes of these Oregon species are different from those of some species from outside Oregon. This is evidence of chromosome evolution in this genus. The absence of structural heterozygosity in meiotic metaphase I of the proposed hybrid suggests that (1) if it is a hybrid, the genomes of the parent species are structurally similar or (2), recurrent backcrossing with the same parent species may have gradually eliminated the chromosomes of the other parent from the hybrid line. High numbers of viable pollen and germinated seeds were found in all the species and the proposed hybrid, evidence that reproductive capacity is not adversely affected by its potentially hybrid condition. Mitosis in tissue culture varies, depending, to a large degree, on cell type. Organized tissues such as roots are sources of more stable karyotypes than calluses, which tend to be mixoploid. The development of plant structures in culture indicates a potential for in vitro plant regeneration.

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21

鄺錦強 und Kam-keung Kong. „Evaluation of fluorescence immunophenotyping and interphase cytogenetics as a tool for investigation of neoplasm (FICTION) in aclinical laboratory and its application on clinical blood and marrowspecimens“. Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B41883044.

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22

Akrami, Seyed Mohammad. „Diagnostic application of human DNA copy number analysis“. Thesis, University of Nottingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250585.

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23

Mi, Rui. „Combined cytogenetic and Y chromosome microdeletion screening in azoospermia and severe oligospermia“. Click to view the E-thesis via HKUTO, 1999. http://sunzi.lib.hku.hk/hkuto/record/B42574973.

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24

Kong, Kam-keung. „Evaluation of fluorescence immunophenotyping and interphase cytogenetics as a tool for investigation of neoplasm (FICTION) in a clinical laboratory and its application on clinical blood and marrow specimens“. Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B41883044.

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25

Wessels, Peter H. „Clinical applications of molecular cytogenetics in astrocytoma grade II“. [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Maastricht University [Host], 2003. http://arno.unimaas.nl/show.cgi?fid=7468.

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26

Cattaneo, E. „Characterisation of chromosomal rearrangements in ERMS using molecular cytogenetics“. Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597372.

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Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood, and comprises a group of heterogeneous malignancies accounting for approximately 10% of all solid tumours in children under 15 years of age. It is a member of the small round blue cell tumours (SRBCT) family. Two main subtypes of RMS are recognised: embryonal (ERMS) and alveolar (ARMS). As is the case for many members of the SRBCT group, ARMS is characterised in 80% of cases by a specific chromosomal rearrangement [t(2;13)(q35;q14) or t(1;13)(p36;q14)] that gives rise to a fusion gene [PAX3/FOXO1A or PAX7/FOXO1A]. The fusion genes are believed to function as aberrant transcription factors. Characterisation of aberrant fusion proteins in human cancer has provided novel diagnostic and prognostic tools, and in some cases novel therapeutic strategies. To date no known cytogenetic abnormality characteristic of ERMS has been identified. This thesis reports the molecular cytogenetic investigation of nine ERMS cell lines (RD, 7763, CT10, RH36, YM, HX170, CCA, JR1, RUCH2) in an attempt to identify a consistent chromosomal aberration for ERMS, the most prevalent RMS subtype. Composite karyotypes of four cell lines (CCA, JR1, RUCH2 and RUCH3) were constructed following the application of an in house molecular cytogenetic screening protocol. A panel of nine ERMS cell line karyotypes was subsequently analysed from which chromosome 15 was revealed to be one of the most frequently rearranged chromosomes in ERMS. Detailed physical mapping of all breakpoints containing chromosome 15 in these nine cell lines suggested a number of genes potentially disrupted; but did not identify a consistent chromosomal aberration. A number of reciprocal chromosomal translocations were identified in the nine ERMS cell lines, and these were investigated in detail. A t(2;15)(q36;q11) in HX170 was noted to result in the disruption of PAX3, and may lead to the formation of a novel fusion gene in this cell line.

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27

Yang, Fengtang. „Chromosome evolution of the muntjacs : inferences from molecular cytogenetics“. Thesis, University of Cambridge, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624925.

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28

Kirby, Simon. „Statistical discrimination in the automation of cytogenetics and cytology“. Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/15181.

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The thesis considers two topics in the automation of cytogenetics and cytology: the automated allocation of human chromosomes to the twenty-four classes which humans possess; and the detection of abnormal cervical smear specimens. For chromosome allocation, the following work is presented and evaluated on a number of data sets derived from chromosome preparations of different quality:1. Three new procedures for modelling between-cell variation.2. Six ways of combining class information on variability in multivariate Normal discrimination.3. Covariance selection models for individual chromosome classes and an assumed common covariance structure for a number of classes.4. Some two-stage procedures for the calculation of discriminant scores in multivariate Normal discrimination.5. The application of some non-parametric and semi-parametric methods.6. The modelling of band-transition sequence probabilities. For the detection of abnormal cervical smear specimens, the use of a consensus probability of a specimen being abnormal, derived from a number of cytologists' assessments, is considered. The sequential use of multiple regression equations to try to predict the logit transformations of these consensus probabilities is described. Finally, the sequential use of features in multivariate discrimination is considered mainly for the case of two known multivariate Normal populations with equal covariance matrices.

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29

Page, Catherine. „Investigation of the cytogenetics of marine and terrestrial gastropods“. Thesis, London Metropolitan University, 1985. http://repository.londonmet.ac.uk/3431/.

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The investigation of the chromosomal variation in populations of the land snail Cepaea nemoralis (L.) marine snail Nucella lapillus (L.) is presented. The first study (Part 1) concerns the investigation of the karyotype of C. nemoralis in populations from a region of the Berkshire Downs (U.K.)in which there are marked area effects for both the visible and allozymic characters. The present investigation has shown that there are inter-populational differences in chromosome structure. The differences fall within the range found previously in several widespread populations in the British Isles, Northern Europe and America. There are no immediately obvious variations in chromosome structure associated with observable environmental variables. There are, however, marked non-random associations of karyomorphs within some of the "area effect populations". The implications of the distribution of the karyotypic variations between the populations are discussed. The second study (Part 11) concerns the identification of the chromosome pairs involved in the numerical (Robertsonian) and structural (inversion) polymorphisms of Nucella lapillus and the investigation of the two types of polymorphism in populations of low chromosome number. A new classification of the karyotype into five main groups A to E has been made. The chromosome pairs thought to contribute to the numerical polymorphism occur in groups A, B and C and the two inversion polymorphisms occur in groups A and C. The distribution of the two types of chromosomal polymorphism at Rottingdean, Sussex (U.K.) suggest that the inversion polymorphism from group C, and the numerical polymorphism, also from group C, occur independently of each other. The differences in the distribution of the two polymorphisms in the Rottingdean area and the differences in the distribution of the chromosome pairs involved in the numerical polymorphism in different populations are discussed.

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30

Williams, Brett. „The use of recombinant human cytokines and FISH in cytogenetics“. Thesis, Queensland University of Technology, 2000.

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31

Stefanou, Eunice-Georgia G. „Chromosome painting using microdissection techniques“. Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364084.

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32

Chapman, Robert Macdonald. „Investigation of the chromosome 13 band q14 lesions in B-cell chronic lymphocytic leukaemia : evidence for a novel tumour suppressor gene“. Thesis, University of Southampton, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242548.

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33

Wargachuk, Richard Burns. „Fine mapping and functional analysis of the radish Rfo nuclear restorer locus“. Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=81454.

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Cytoplasmic male sterility (CMS) is a widespread, maternally inherited trait that results in an inability of plants to produce functional pollen. The Ogura CMS system originated in radish, but has since been transferred to, and confers male sterility on, plants in the related genus Brassica . A gene which restores male fertility is needed for the Ogura CMS system to be exploited commercially for hybrid seed production in oilseed species such as Brassica napus. The restorer gene Rfo is a dominant radish nuclear gene that restores the male fertility to plants with Ogura cytoplasm. This gene has been transferred into Brassica napus through intergeneric crosses; however the introgressed segment of radish DNA contains an unknown number of genes, some of which confer undesirable traits, such as an elevated content of seed glucosinolates, antinutritive compounds that render the seed meal unusable as animal feed. A fine scale linkage map of the region in radish containing Rfo was constructed, and a map-based cloning approach relying on synteny between radish and Arabidopsis was used to clone Rfo. A radish gene encoding a 687 amino acid protein with a predicted mitochondrial targeting presequence was found to confer male fertility upon transformation into Ogura CMS B. napus . This gene, codes for a pentatricopeptide repeat (PPR)-containing protein with multiple, in this case 16, PPR domains. Two similar genes that do not appear to function as Rfo flank this gene. A transcript representing a non-functional allele (rfo) was detected in sterile radish plants. Comparison of the Rfo region with the syntenic Arabidopsis region indicates that a PPR gene is not present at the Rfo-equivalent site in Arabidopsis , although a smaller and related PPR gene is found about 40 kb from this site.

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34

Kim, Mee Hye. „Optimisation and application of comparative genomic hybridisation (CGH) in cancer cytogenetics“. Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272858.

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35

Harley, Alyssa Skye. „Analysis of a nuclear role for 'pebble', a gene required for cytokinesis in Drosophila“. Title page, abstract and table of contents only, 2002. http://web4.library.adelaide.edu.au/theses/09PH/09phh284.pdf.

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"May 2002" Bibliography: leaves 157-176. Through the use of a variety of biochemical and genetic techniques, the importance of the nuclear localisation of PBL was examined, as well as the function of its RadECl and BRCT domains. The RadECl/BRCT domains were found to be required in the cytoplasm for cytokinesis, extending the range of function attributed to these domains. PBL was also shown to shuttle between the nucleus and the cytoplasm, providing an explanation for the observed ability of nuclear PBL to influence cytoplasmic structure.

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36

Zhu, Hong. „Genetic and expression analysis of candidate tumor loci in non-small cell lung cancer“. Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B35328368.

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37

Nousch, Marco Biotechnology &amp Biomolecular Sciences Faculty of Science UNSW. „The role of the translational regulator p97 in mammalian cells“. Awarded by:University of New South Wales. Biotechnology & Biomolecular Sciences, 2008. http://handle.unsw.edu.au/1959.4/41445.

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Members of the eukaryotic initiation factor 4G (eIF4G) family play a central role in the translation initiation process. One member of this family is p97 (also called DAP5 and NAT1), a protein that is highly homologous to the C-terminal two thirds of eIF4G. Overexpression studies suggested that p97 is a pure translational repressor that has to be cleaved into a shorter form called p86, in order to show translational activity. In this study a series of experiments indicated that full length p97 has a number elF property such as association with active translating ribosomes, stimulatory effects in the Direct Initiation Factor assay and accumulation in stress granules. Additionally the endogenous p97 complex was isolated from HeLa cells and mRNA as well as the protein components were characterized. P97 associated mRNAs were described by a custom made 5'UTR focus array, showing that the protein binds to a broad range of mRNA. The relative lack of mRNA specificity argues for a general role of p97 in translation, which does not seems to be essential in unchallenged cells, because a down regulation of p97 protein levels has no effect on the translational status of the bulk of mRNAs. Mass spectrometry analysis revealed a novel protein-protein interaction between p97 and DNA methyltransferase 1 (Dnmt1), which does not rely on a nucleic acid. For this interaction the C- and N-terminus of p97 play a critical role. Further, Dnmt1 has the ability to interact with elF4G and the small ribosomal subunit, which might provide evidence for a novel function of Dnmt1 in RNA metabolism.

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38

Chan, Kit-ying Loucia. „Expression analysis of Candidate cancer genes in non-small cell lung cancer /“. View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38480360.

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39

Chu, Chi-yuen Andrew. „A study on mitochondrial uncoupling protein 4 (UCP4) in Parkinsonian models“. Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B39634449.

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40

Lee, Yuk-kwan Mary. „Molecular changes in regenerated and senescent cultured endothelial cells“. Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B38765512.

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41

Finnegan, Patrick Michael. „RNA synthesis in maize mitochondria : the identification of autonomously replicating RNA species and a kinetic analysis of transcript accumulation“. Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75931.

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Transcription in mammalian and yeast mitochondria proceeds from a few well defined promoters, with processing of polycistronic transcripts producing the mature RNAs. The levels of different sequences in the steady-state RNA populations depend on differential promoter strengths, transcription attenuation and/or selective termination, and differential RNA stabilities. To gain insights into the processes governing transcription and RNA levels in plant mitochondria, a system using isolated maize mitochondria, which synthesize bona fide mitochondrial RNAs, was developed and partially characterized with respect to exogenous requirements and sensitivity to inhibitors of DNA-dependent RNA synthesis.
Although initiation and processing probably occur at reduced levels in isolated maize mitochondria, endogenous DNA templates are extensively transcribed at the same relative rates as in vivo. Isolated maize mitochondria were used to demonstrate that differential rates of both synthesis and turnover help determine the steady-state abundances of various mitochondrial RNA sequences and that mitochondria from certain lines possess an autonomously-replicating, RNA-based genetic system.

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42

Zhao, Ping 1955. „Effects of mus mutations on mitotic recombination in Aspergillus nidulans“. Thesis, McGill University, 1990. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=60456.

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Nine mutagen sensitive (mus) mutants of Aspergillus nidulans were analyzed for effects on recombination. These mus show increased sensitivity to various mutagens; several were UV-sensitive. The majority were sterile in homozygous crosses homozygous mus diploids were essential to test for mitotic recombination.
Two distinct tests were used: intergenic recombination between colour mutations and their centromeres; and, intragenic recombination between two distinguishable adE alleles. Both hyper- and hypo-rec mus mutations were identified, with 15- to 20-fold differences between them. Three mutations musN, musO, and musQ had greatly elevated recombination frequencies. Only one, musL significantly reduced recombination but consequently increased malsegregation.
Analysis of the genotype of ad$ sp{+}$ recombinants, from musN and musL diploids, revealed qualitative differences from mus$ sp{+}$. musN enhanced mitotic crossing over but not gene conversion; while musL reduced the frequency of simple convertants but increased that of complex homozygous ad$ sp{+}$ genotypes. Mitotic conversion and crossing over, generally associated with each other, were uniquely affected in such mus diploids.

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43

Chu, Chi-yuen Andrew, und 朱志遠. „A study on mitochondrial uncoupling protein 4 (UCP4) in Parkinsonian models“. Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39634449.

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44

米銳 und Rui Mi. „Combined cytogenetic and Y chromosome microdeletion screening in azoospermia and severe oligospermia“. Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B42574973.

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45

Srinivasan, Supriya. „Developmentally regulated protein secretion in Dictyostelium discoideum /“. free to MU campus, to others for purchase, 2000. http://wwwlib.umi.com/cr/mo/fullcit?p9999318.

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46

Nordkvist, Anders. „Genetic alterations in salivary gland tumors“. Göteborg : Dept. of Oral Pathology, University of Göteborg, 1993. http://catalog.hathitrust.org/api/volumes/oclc/30761016.html.

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47

BELL, CARL WAYNE. „CYTOGENETIC EVALUATION OF HUMAN GLIAL TUMORS: CORRELATION OF OVEREXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) WITH ABNORMALITIES OF CHROMOSOME 7“. Diss., The University of Arizona, 1987. http://hdl.handle.net/10150/184108.

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Chromosome banding analysis of human glial tumors was performed using G- and Q-banding techniques in an attempt to establish recurring sites of chromosome change. Results revealed a nonrandom karyotypic profile including aneuploidy and considerable variation in chromosome number (range 40 → 200). All tumors examined displayed numerical abnormalities, with the most common numeric change being a gain of chromosome 7. Chromosomes most frequently involved in structural abnormalities included #1, #3, #7, and #11. Double minutes, reported to be frequently associated with human glial tumors, were observed in only one of ten tumors examined. These results (taken in conjunction with previously published reports) suggest that the single most frequently altered chromosome in human glial tumors is chromosome 7. An attempt was then made to correlate the observed chromosome 7 changes with activation of the cellular proto-oncogene c-erb-B, whose product is the epidermal growth factor receptor (EGFR). Six human glial tumors were analyzed for ¹²⁵I-EGF binding, EGFR gene copy number, EGFR gene rearrangement, mRNA expression, and karyotypic profile. Saturation analysis at 4°C revealed significant numbers of EGFR's in all 6 tumors. Southern blotting analysis utilizing cDNA probes for the EGFR failed to demonstrate significant amplification or structural rearrangement of the EFGR gene. Analysis of EGFR mRNA revealed significant levels in 3 of the tumors studied as compared to the A341 cell line. Karyotypic analysis revealed that all six cell lines displayed extra copies of both whole and structurally altered chromosome 7. These results may suggest that EGFR overexpression is associated with alterations of chromosome 7 (the locus for the EGFR gene). In contrast to previous reports, EGFR mRNA levels did not directly parallel EGF receptor numbers. These results suggest that overexpression of the EGFR may be related to an alternative mechanism, other than gene amplification and elevated mRNA levels, such as the regulation of receptor biosynthesis and degradation. In summary, findings indicate that alterations of chromosome 7 are the most prevalent chromosomal change in human glial tumors, and that these alterations may lead to overexpression of the proto-oncogene c-erb-B.

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48

Venkatanagappa, Shoba. „Cytogenetic manipulation and anther culture of wheat“. Thesis, Faculty of Agriculture, 1993. https://hdl.handle.net/2123/11992.2.

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The experiments in this thesis manipulated the breeding system of wheat and triticale first toward outcrossing with male sterility systems, and then toward homozygosity with anther culture systems. To provide a visible marker that could be used to distinguish male-sterile plants from male-fertile plants, 'chromosome engineering' was attempted via two distinct crossing procedures to generate two translocation chromosomes, 5AL.5AS-5RS and 4EL-5AS. These would then be recombined (via an intercrossing procedure) into another translocation chromosome 4EL.5AS—5RS which would link the blue aleurone gene Ba on chromosome 4EL with the dominant male sterility allele Ms3 on chromosome arm SAS, while chromosome arm segment SRS would prevent pairing and crossing over with other SAS arms in heterozygous breeding lines. The procedure to develop the first translocation chromosome consisted of crossing dominant male-sterile (DMS) Selkirk wheat with the 5R(5A) substitution line in Chinese Spring wheat. The progeny were further crossed with ph1b mutant in Chinese Spring wheat to allow homoeologous pairing and recombination to occur between chromosomes 5A and 5K Morphological, cytological and genetic markers were used to evaluate the progeny derived from these crosses. The required traits were 1. Presence of 2n = 41, 2. Speltoid heads indicating monosomy for chromosome 5A 3. Sterile anthers indicating the presence of M33. 4. Presence of B-Amy—AZ bands and IBF bands indicating the presence of chromosome arm SAL. 5. Lack of 'hairy neck' phenotype, B-Amy-R2 and [bf—R1 bands indicating the absence of chromosome arm SRL. 6. Positive dot-blot for the rye-specific DNA probe indicating the likely presence of a rye segment or arm from chromosome arm 5R8. One progeny which had a combination of these characteristics was consistent with the required translocation chromosome. The procedure for the second translocation chromosome involved crossing DMS-Selkirk with the chromosome 4E addition line 'Blue Tordo' and backcrossing with N5AT5D in Chinese Spring. This enabled the maintenance of chromosomes 5A and 4E as monosomes thus providing an opportunity for them to misdivide and reunite (centric fusion). The progeny were evaluated using morphological and cytological markers. The required characters were 1. Blue seed color. 2. Sterility of anthers. 3. Speltoidy of heads. 4. 2n = 42 chromosomes. The results obtained indicated that although one plant with most of the above mentioned traits was recovered, its anthers were partially fertile. In addition, M33 segregated independently of Ba indicating that the required translocation chromosome was not obtained. The restoration of partial fertility is the first instance of partial restoration of DMS which was previously considered to be obligate male sterility. In general it is recommended that the translocation obtained from the first crossing procedure be further confimed by analyses with the C-banding technique or by in situ hybridization methods to confim the presence of chromosome arm SRS and to evaluate the length of rye segment. Further, alternative sources of the blue aluerone marker such as T. boeoticum should also be investigated. The potential for using the DMS gene Ms3 in triticale was also investigated. Wheat-rye amphihaploids derived from crosses between Selkirk DMS wheat and four rye populations (Chapter 4) were treated with colchicine, and DMS triticales were derived from only two S. cereale selections. Male sterility was expressed in both wheat-rye amphihaploids as well as in primary and secondary triticales inspite of the presence of rye chromosomes. The stability of expression of male sterility in these triticales indicated that dominant male sterility could be used in breeding programs. Experiments to enhance the efficiency of anther culture for use as a wheat breeding tool were conducted using cv. Grebe and MC17 medium as model systems. The media were modified using alternative support substrates, carbohydrate sources and plant growth regulators. The data quantified were induction of embryoids, direct plant production, green and albino plant regeneration, proportion of green plants to total regenerants. In addition, the survival of green regenrants upon transfer to soil was evaluated together with the seed set obtained probably due to spontaneous doubling.

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49

Venkatanagappa, Shoba. „Cytogenetic manipulation and anther culture of wheat“. Phd thesis, Faculty of Agriculture, 1993. http://hdl.handle.net/2123/11992.

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Hui, Koon-chun Eleanor. „Characterization of PML/RARA fusion in acute promyelocytic leukemia : molecular cytogenetics study /“. View the Table of Contents & Abstract, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31495369.

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