Auswahl der wissenschaftlichen Literatur zum Thema „Cymbopogan pendulus“

Antibiotic resistance in bacteria is the major concern worldwide. PBP (Penicillin binding proteins) have been cited as an appropriate target for therapeutic drug design. In the present study molecular docking followed by wet lab validation was designed to estimate the effect of potent bioactive molecules from Cymbopogan pendulus essential oil against PBP5 protein. GC-FID (gas chromatography with flame-ionization detection) based composition profile, and in-silico docking study was conducted by using CB-dock 2 analysis followed by 2D and 3D interactions. GC-FID revealed Limonene, Neral, Geranial, Linalool, Myrcene as major and minor compounds in Cymbopogan pendulus essential oil. The docking score indicated effective binding of ligands to PBP5. Interactions results indicated that, PBP5/ligand complexes form hydrogen and hydrophobic interactions. Wet lab study validated the anti-bacterial potential of oil against gram-positive and gram-negative bacteria. Therefore, essential oil from Cymbopogan pendulus essential oil may represent potential herbal treatment to mitigate bacterial infections.

Lemongrasses found in India encompass Cymbopogon flexuosus, C. citratus, C. khasianus, and C. pendulus. This fragrant perennial grass belongs to the Poaceae family and is indigenous to India as well as other tropical and subtropical regions in Southeast Asia and Africa. Pinpointing its precise place of origin is challenging due to its extensive history of cultivation and utilization across various cultures. It is believed to have originated in the maritime Southeast Asian region, encompassing countries like India, Sri Lanka, Indonesia, and Malaysia. Lemongrass thrives in these regions and has played a significant role in their culinary and medicinal traditions for many generations. Among these, Cymbopogon citratus, a tropical lemongrass variety, is native to multiple Asian regions, particularly Southeast Asia and South Asia. It is widely cultivated and employed in a range of global cuisines and traditional healing practices. Lemongrass finds extensive applications in the herbal, medicinal, cosmetic, pharmaceutical, and fragrance industries. Lemongrass oil is known for its diverse biological properties, which encompass antibacterial, immunomodulatory, and antioxidant effects. Not too long ago, India ranked as one of the world' leading exporters of lemongrass essential oil. Several prominent lemongrass cultivars have emerged, including GRL-1 (geraniol-rich), Krishna, Cauveri, Pragati, Praman, T-1, CIM Shikhar, Chirharit, CKP-25, SD-68, CIMAP Suwarna, and Krishnapriya. Among these, CIMAP Suwarna, Krishna, and CIM Shikhar stand out as the most widely favoured varieties across India developed at the CSIR-CIMAP in Lucknow, India. Indian universities and research institutions have also played a pivotal role in the development of novel lemongrass cultivars. Examples include Jor Lab L-2, OD-19, SD-68 (C. flexuosus), RRL-16 (C. pendulus), and CKP-25. Notably, there's Jor Lab L-9, a distinctive strain of C. khasianus known for its high methyl eugenol content. Furthermore, the germplasm for Malabar lemongrass (C. khasianus) is notable for its abundant herbage and elevated elemicin content, reaching up to 70%. The CSIR-NEIST in Jorhat and the CSIR-CIMAP, Lucknow have contributed to the development of new high geraniol-rich lemongrass cultivars, such as "Jor Lab L-15" (C. khasianus), GRL-1, and CIM Atal (C. flexuosus), respectively. b: citral, elemicin, geraniol, methyl eugenol content, vitamin A, Cymbopogon, flexuosus, Cymbopogon pendulus, Cymbopogon khasianus, Cymbopogon citratus, Lemongrass varieties Citral, Cymbopogon citratus, Cymbopogon flexuosus, Cymbopogon khasianus, Cymbopogon pendulus, Elemicin, Geraniol, Lemongrass varieties, Methyl eugenol content, Vitamin A

Two species of grasses, Chrysopogon hamiltonii and Cymbopogon pendulus are being reported as new distributional records for the South India. This paper presents an illustrated account of both the species.

The present study deals with the encapsulation of Cymbopogon khasiana × Cymbopogon pendulus essential oil (CKP-25-EO) into a chitosan nanoemulsion and efficacy assessment for inhibition of fungal inhabitation and aflatoxin B1 (AFB1) contamination in Syzygium cumini seeds with emphasis on cellular and molecular mechanism of action. DLS, AFM, SEM, FTIR, and XRD analyses revealed the encapsulation of CKP-25-EO in chitosan with controlled delivery. The CKP-25-Ne displayed enhanced antifungal (0.08 µL/mL), antiaflatoxigenic (0.07 µL/mL), and antioxidant activities (IC50 DPPH = 6.94 µL/mL, IC50 ABTS = 5.40 µL/mL) in comparison to the free EO. Impediment in cellular ergosterol, methylglyoxal biosynthesis, and in silico molecular modeling of CKP-25-Ne validated the cellular and molecular mechanism of antifungal and antiaflatoxigenic activity. The CKP-25-Ne showed in situ efficacy for inhibition of lipid peroxidation and AFB1 secretion in stored S. cumini seeds without altering the sensory profile. Moreover, the higher mammalian safety profile strengthens the application of CKP-25-Ne as a safe green nano-preservative against fungal association, and hazardous AFB1 contamination in food, agriculture, and pharmaceutical industries.

Puji dan syukur kami panjatkan kepada Tuhan Yang Maha Esa atas rahmat dan hidayahNya, Jurnal Jamu Indonesia Volume 8 No 1 tahun 2023 dapat diterbitkan. Jurnal Jamu Indonesia merupakan media untuk diseminasi hasil penelitian yang berkaitan dengan jamu di Indonesia. Jamu telah dikenal lama penduduk Indonesia sebagai salah satu pengobatan. Berbagai tanaman di Indonesia sangat berpotensi sebagai jamu. Penelitian tanaman obat dari bagian daun, batang, dan rimpang tanaman telah banyak dilakukan dan terus berkembang. Jurnal Jamu Indonesia pada Volume 8 No 1 Tahun 2022 terdiri atas 4 naskah. Naskah diterbitkan memiliki tema beragam, meliputi: Studi Etnofarmasi Tanaman Obat Untuk Perawatan dan Pengobatan Luka di Indonesia: Pencarian Data Sistematis dan Tinjauan Secara Praklinik; Review: Ekstraksi Rimpang Temulawak (Curcuma xanthorrhiza Roxb.) dan Aktivitas Sebagai Antibakteri; Penentuan Kadar Sitronelal Total dan Pengembangan Model Klasifikasi FTIR-Kemometrik Minyak Jowitt Cymbopogon winterianus dari Berbagai Ketinggian Daerah Tanam; dan Uji Ekstrak Alkohol Daun Mengkudu (Morinda Citrifolia L) terhadap Konsentrasi Kreatinin dan Ureum Tikus Putih Jantan (Rattus Norvegicus) Nefropati Diabetes. Redaksi mengucapkan terima kasih kepada seluruh penulis atas partisipasinya dalam berbagi hasil penelitiannya melalui publikasi di Jurnal Jamu Indonesia. Redaksi juga mengucapkan terima kasih kepada seluruh reviewer atas partisipasinya dalam meningkatkan kualitas tulisan naskah jurnal di edisi ini. Semua hasil karya tersebut akan diarsipkan sebagai dokumentasi berharga demi terjaganya informasi yang dapat menjadi sumber pengembangan ilmu pengetahuan di masa depan. Kontribusi publikasi peneliti-peneliti dan pejuang Jamu Indonesia terus kami harapkan untuk dapat disampaikan di dalam Jurnal Jamu Indonesia ini. Peningkatan kontribusi jumlah dan kualitas tulisan yang telah dan akan dimasukkan akan dapat membantu pengembangan jurnal ini, dan pada saatnya diharapkan juga dapat menjadikan Jurnal Jamu Indonesia menjadi referensi baik secara nasional, maupun internasional. Mei 2023 Muhamad Rafi Ketua Dewan Redaksi