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Veröffentlicht am 25. Mai 2024

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Zeitschriftenartikel zum Thema "CyclineB"

Yi, Xie, und Li Bing. „The Transcription Express Characteristics of Several Genes in the Process of Bombyx mori Ovarian Carcinoma“. Advanced Materials Research 796 (September 2013): 39–42. http://dx.doi.org/10.4028/www.scientific.net/amr.796.39.

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Bombyx mori cell line (BmN) comes fromBombyx moriovary cell subculture. In order to study the change of several genes transcription in the process ofBombyx moriovary cells primary culture and subculture, we usedBombyx moriovary organizations and BmN cell lines as research materials, used Real Time fluorescent quantitative RT-PCR to detect cyclin gene family (CyclinA, CyclinB, CyclinB3, CyclinE, CyclinL1), p53 and Telomerase genes transcription level in the ovary and BmN cell lines, and took Actin3 gene as reference to dispose the results. The results showed that in theBombyx moriBmN cell lines the expression of CyclinA, CyclinB, CyclinB3, CyclinE, CyclinL1 and Telomerase genes were higher than those in the ovary. The expression of CyclinB in the BmN was more then 3.8 which was 76 times higher than that in the ovary; The expression of p53 gene in the BmN cell was lower than that in the ovary; The expression of Telomerase gene in the BmN cell was higher than that in the ovary. The results accumulated a reliable data for further study on the the role of cyclin gene family, p53 gene, and Telomerase gene in the process ofBombyx moriovarian carcinoma.

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Buchkovich, K. J., und E. B. Ziff. „Nerve growth factor regulates the expression and activity of p33cdk2 and p34cdc2 kinases in PC12 pheochromocytoma cells.“ Molecular Biology of the Cell 5, Nr. 11 (November 1994): 1225–41. http://dx.doi.org/10.1091/mbc.5.11.1225.

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In the absence of serum, nerve growth factor (NGF) promotes the survival and differentiation of the PC12 pheochromocytoma cell line. In the presence of serum, NGF acts primarily as a differentiation factor and negative regulator of cell cycling. To investigate NGF control of cell cycling, we have analyzed the regulation of cyclin dependent kinases during PC12 cell differentiation. NGF treatment leads to a reduction in the steady-state protein levels of p33cdk2 and p34cdc2, two key regulators of cell cycle progression. The decrease in p33cdk2 and p34cdc2 coincides with a decrease in the enzymatic activity of cyclinA-p34cdc2, cyclinB-p34cdc2, cyclinE-p33cdk2, and cyclinA-p33cdk2 kinases. The decline in p33cdk2 and p34cdc2 kinase activity in response to NGF is accelerated in cells that over-express the p140trk NGF receptor, suggesting that the timing of the down- regulation is dependent on the level of p140trk and the strength of the NGF signal. The level of cyclin A, a regulatory subunit of p33cdk2 and p34cdc2, is relatively constant during PC12 differentiation. Nevertheless, the DNA binding activity of the cyclinA-associated transcription factor E2F/DP decreases. Thus, NGF down-regulates the activity of cyclin dependent kinases and cyclin-transcription factor complexes during PC12 differentiation.

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Сальков, Николай, und Nikolay Sal'kov. „Representations of Dupin Cyclides“. Geometry & Graphics 5, Nr. 3 (28.09.2017): 11–24. http://dx.doi.org/10.12737/article_59bfa354466be1.50763524.

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We know very little about such an interesting surface as Dupin cyclide. It belongs to channel surfaces, its special cases are tor, conical and cylindrical surfaces of rotation. It is known that Dupin cyclides are the only surfaces whose focal surfaces, that are surfaces consisting of sets of curvatures centers points, have been degenerated in second-order curves. Two sets give two confocal conics. That is why any study of Dupin cyclides is of great interest both scientific and applied. In the works devoted to Dupin cyclide and published in the "Geometry and Graphics" journal, are presented various properties of cyclides, and demonstrated application of these surfaces in various industries, mostly in construction. Based on the cyclides’ properties in 1980s have been developed numerous inventions relating to devices for drawing and having the opportunity to be applied in various geometric constructions with the use of computer technologies. In the present paper have been considered various options for representation of Dupin cyclides on a different basis – from the traditional way using the three given spheres unto the second-order curves. In such a case, if it is possible to represent four cyclides by three spheres, and when cyclide is represented by the second-order curve (konic) and the sphere their number is reduced to two, then in representation of cyclide by the conic and one of two cyclide’s axes a single Dupin cyclide is obtained. The conic itself without any additional parameters represents the single-parameter set of cyclides. Representations of Dupin cyclides by ellipse, hyperbola and parabola have been considered. The work has been sufficiently illustrated.

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Belbis, Bertrand, Lionel Garnier und Sebti Foufou. „Construction of 3D Triangles on Dupin Cyclides“. International Journal of Computer Vision and Image Processing 1, Nr. 2 (April 2011): 42–57. http://dx.doi.org/10.4018/ijcvip.2011040104.

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This paper considers the conversion of the parametric Bézier surfaces, classically used in CAD-CAM, into patched of a class of non-spherical degree 4 algebraic surfaces called Dupin cyclides, and the definition of 3D triangle with circular edges on Dupin cyclides. Dupin cyclides was discovered by the French mathematician Pierre-Charles Dupin at the beginning of the 19th century. A Dupin cyclide has one parametric equation, two implicit equations, and a set of circular lines of curvature. The authors use the properties of these surfaces to prove that three families of circles (meridian arcs, parallel arcs, and Villarceau circles) can be computed on every Dupin cyclide. A geometric algorithm to compute these circles so that they define the edges of a 3D triangle on the Dupin cyclide is presented. Examples of conversions and 3D triangles are also presented to illustrate the proposed algorithms.

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Garnier, Lionel, Lucie Druoton, Jean-Paul Bécar, Laurent Fuchs und Géraldine Morin. „Subdivisions of Ring Dupin Cyclides Using Bézier Curves with Mass Points“. WSEAS TRANSACTIONS ON MATHEMATICS 20 (09.11.2021): 581–97. http://dx.doi.org/10.37394/23206.2021.20.62.

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The paper deals in the Computer-Aided Design or Computer-Aided Manufacturing domain with the Dupin cyclides as well as the Bézier curves. It shows that the same algorithms can be used either for subdivisions of ring Dupin cyclides or Bézier curves. The Bézier curves are described with mass points here. The Dupin cyclides are considered in the Minkowski-Lorentz space. This makes a Dupin cyclide as the union of two conics on the unit pseudo-hypersphere, called the space of spheres. And the conics are quadratic Bézier curves modelled by mass points. The subdivision of any Dupin cyclide, is equivalent to subdivide two curves of degree 2, independently, whereas in the 3D Euclidean space, the same work implies the subdivision of a rational quadratic Bézier surface and resolutions of systems of three linear equations. The first part of this work is to consider ring Dupin cyclides because the conics are bounded circles which look like ellipses.

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Srinivas, Y. L., und Debashish Dutta. „Cyclides in Geometric Modeling: Computational Tools for an Algorithmic Infrastructure“. Journal of Mechanical Design 117, Nr. 3 (01.09.1995): 363–73. http://dx.doi.org/10.1115/1.2826689.

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The Dupin cyclide is a quartic surface with useful properties such as circular lines of curvature, rational parametric representations and closure under offsetting. All natural quadrics (cone, cylinder, sphere) and the torus are special cases of the cyclide. Applications of cyclides include variable radius blending, piping design and design of tubular geometry, such as mold gates and wire harnesses. While the mathematical treatment of cyclides is well developed, the tools required to incorporate this surface into conventional modeling applications have not received sufficient attention. In this paper, we detail various methods for manipulating and computing with the cyclide. Issues such as auxiliary representations, inverse parameter mapping, point classification, normal projection of a point onto the surface, distance computation, bounding volumes and surface intersection detection are discussed in detail. We also provide implemented examples of design applications that utilize these computational tools.

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Сальков und Nikolay Sal'kov. „Properties of Dupin Cyclide and Their Application. Part 4: Applications“. Geometry & Graphics 4, Nr. 1 (17.03.2016): 21–33. http://dx.doi.org/10.12737/18055.

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In the first and second parts of the work there were considered mainly properties of Dupin cyclide, and given some examples of their application: three ways of solving the problem of Apollonius using only compass and ruler, using the identified properties of cyclide; it is determined that the focal surfaces of Dupin cyclid are degenerated in the lines and represent curves of the second order – herefrom Dupin cyclide can be defined by conic curve and a sphere whose center lies on the focal curve. Polyconic compliance of these focal curves is identified. The formation of the surface of the fourth order on the basis of defocusing curves of the second order is shown. In this issue of the journal the reader is invited to consider the practical application of Dupin cyclide’s properties. The proposed solution of Fermat’s classical task about the touch of the four spheres by the fifth with a ruler and compass, i.e., in the classical way. This task is the basis for the problem of dense packing. In the following there is an application of Dupin cyclide as a transition pipe element, providing smooth coupling of pipes of different diameters in places of their connections. Then the author provides the examples of Dupin cyclide’s application in the architecture as a shell coating. It is shown how to produce membranes from the same cyclide’s modules, from different modules of the same cyclide, from the modules of different cyclides, from cyclides with the inclusion of other surfaces, special cases of cyclides in the educational process. The practical application of the last problem found the place in descriptive geometry at the final geometrical education of architects in the "Construction of surfaces". Here such special cased of cyclides as conical and cylindrical surfaces of revolution.

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Sun, Lu, Yan Pan, Xiaochun Wang, Gang Gao, Lina Wu, Chunnan Piao, Jianlei Ruan und Jianxiang Liu. „Screening for Potential Biomarkers in Peripheral Blood From Miners Exposed to Radon Radiation“. Dose-Response 18, Nr. 1 (01.01.2020): 155932582090460. http://dx.doi.org/10.1177/1559325820904600.

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In this cohort study of 144 miners, 72 miners worked underground (the study group) and 72 miners worked aboveground (the control group). Based on questionnaire data and of radon concentration measurements, the cumulative radon exposure dose was calculated for each miner using the parameters recommended in International Commission on Radiological Protection Publication 137. Hematological parameters such as lymphocyte count (LYM) and neutrophil count (NE) were assessed, cell cycle phases and regulatory proteins were detected by flow cytometry, and microRNA (miRNA) microarray screening and real-time polymerase chain reaction (PCR) were used to detect miRNAs in plasma. The interrelationships between various potential biomarkers were analyzed using bioinformatics and statistical methods. The mean cumulative exposure dose of underground miners and controls was 982 and 48 mSv, respectively. Hematological parameters (such as LYM and NE) were significantly lower in the underground group. Cyclin-dependent kinase (CDK)-2, CDK4, CDK6, CyclinA2, CyclinD1, and CyclinE1 were significantly higher in the underground group. MicroRNA microarray screening showed that 5 miRNAs were downregulated (fold-change >2) in the underground group. The real-time PCR detection results of miR-19a, miR-30e, miR-335, and miR-451a were consistent with the screening results. LYM, NE, CDK2, CDK4, CDK6, Cyclin A2, Cyclin D1, Cyclin E1, miR-19a, miR-30e, miR-335, and miR451a are potential biomarkers of radon radiation damage.

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Garnier, Lionel, Lucie Druoton, Jean-Paul Bécar, Laurent Fuchs und Géraldine Morin. „Subdivisions of Horned or Spindle Dupin Cyclides Using Bézier Curves with Mass Points“. WSEAS TRANSACTIONS ON MATHEMATICS 20 (31.12.2021): 756–76. http://dx.doi.org/10.37394/23206.2021.20.80.

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This paper shows the same algorithm is used for subdivisions of Dupin cyclides with singular points and quadratic Bézier curves passing through infinity. The mass points are usefull for any quadratic Bézier representation of a parabola or an hyperbola arc. The mass points are mixing weighted points and pure vectors. Any Dupin cyclide is considered in the Minkowski-Lorentz space. In that space, the Dupin cyclide is defined by the union of two conics laying on the unit pseudo-hypersphere, called the space of spheres. The subdivision of any Dupin cyclide, is equivalent to subdivide two Bézier curves of degree 2 with mass points, independently. The use of these two curves eases the subdivision of a Dupin cyclide patch or triangle.

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Srinivas, Y. L., und D. Dutta. „Blending and Joining Using Cyclides“. Journal of Mechanical Design 116, Nr. 4 (01.12.1994): 1034–41. http://dx.doi.org/10.1115/1.2919484.

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We consider the use of Dupin cyclides in geometric modeling. These are algebraic surfaces of degree four with interesting properties such as rational parametric forms and closure under offsets. We have been focusing on methods for expanding the geometric coverage of solid modelers, and the cyclide as a new primitive offers promise. In this paper, we briefly describe the cyclide and discuss in details two applications. The first is the modeling of blending surfaces, an important problem in geometric modeling. We outline methods to use various forms of the cyclide in variable-radius blending. Next, we consider the problem of automatic joining of pipes, and describe a general method rooted in the definition of a cyclide for its solution. Implemented examples are provided for both applications.

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Dissertationen zum Thema "CyclineB"

Chaves, Ferreira Miguel. „The role of cyclin D1 in lymphopoiesis“. Phd thesis, Université René Descartes - Paris V, 2012. http://tel.archives-ouvertes.fr/tel-00765134.

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D Cyclins play an essential role connecting exogenous stimulation to the intrinsic cell cycle machinery. This family of proteins is composed of three members sharing a highly homologous domain, the cyclin box (coded by exons 1-3), which is responsible for their redundant role in the phosphorylation of the retinoblastoma protein upon association with cydin-dependent kinases Cdk4/6. Both mature T and B-cells have a remarkable division capability after antigen stimulation, essential to the generation of efficient immune responses, raising the interest of D Cyclins in lymphopoiesis. Cyclin Dl, although weakly expressed by lymphocytes, is the D Cyclin most commonly implicated in lymphoid cancers and as having a Cdk-independent transcriptional role. To study the role of Cyclin Dl, we used mice deficient for the Dl cyclin box but sparing exons 4-5. Surprisingly, individual mice have very different phenotypes that we subdivided into four arbitrary groups. Group I mice show the most precocious block in lymphoid lineage differentiation, illustrated by a low cellularity of common lymphoid progenitor cells (CLP). The thymi showed very few CD4*CD8*, double positive (DP) cells, while the CD4 CD8TCR, triple negative (TN) populations were found to be mostly constituted by the early CD44*CD25' (TNI) and few CD44*CD25* (TN2). TNl's early thymocyte progenitors (ETP) were virtually absent. At the B-cell lineage level in the bone marrow (BM) there was a major block in pre-proB differentiation. The number of peripheral T-cells was severely reduced, mainly in LN, since group I T-cells lack CCR7 expression. Group II mice presented moderate thymus atrophy. The block on TN differentiation occurs at a later stage, i.e., in the TN3 to TN4 transition, and the TNI population was characterized by a less severe depletion of the ETP. Group II mice showed a partial pre-proB block and a reduction in pre-B-cells. CLPs were also reduced but to a lesser extent than in group I mice. Group ill and group IV mice appear to have a normal thymocyte population distribution but showed an increase on ETP compartment. Group IV mice displayed thymic hyperplasia while group III mice possessed normal thymus cellularity. B-cell differentiation on both groups appeared to be normal but BM precursors had an increase in both CLP and early haematopoietic progenitor's (LSK) levels as compared with wild type mice. Cyclin Dl involvement in G1 to S transition led us to analyse in vivo division rates. Strikingly, group I mice were virtually devoid of cycling cellsin all lymphoid compartments, explaining why lymphoid lineage cells do not differentiate in these mice. In contrast, in all other groups we observed an increased BrdU incorporation. These contradicting phenotypes correlated with the expression or absence of a truncated Dl protein coded by exons 4-5. The presence of the cyclin Dl truncated mRNA was not found in group I mice but high levels of expression are consistently observed in the remaining groups. In the absence of the Dl truncated protein only trace values of Cyclins D2 and D3 were found, highlighting the role of this protein as a master D cyclin regulator, which further supports the profound aplasia and arrest in lymphoid lineage division on cells that predominantly express Cyclin D2. These results suggest that, while the function of the Dl cyclin box is redundant, the regulatory domain coded by exons 4-5 is fundamental for lymphopoiesis. Full Dl protein was also eliminated by RNA interference both in vitro and in vivo. These experiments reproduced the phenotype of group I mice. We have developed a lentiviral vector with a truncated Dl (exons 4-5) and conditional knockout (KO) mice by floxing exons 4-5 of cyclin Dl. These tools will allow us to show Cyclin Dl Cdk-independent role as a transcription regulator in lymphopoiesis and to attribute this function to exons 4-5. Understanding how exons 4-5 regulate different transcription factors might be a key in...

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Mata, Xavier. „Analyse structurale et fonctionnelle de gènes voisins du "locus" de l'α-lactalbumine caprine : application à la recherche d'éléments "cis"-régulateurs à effet dominant“. Limoges, 2003. http://www.theses.fr/2003LIMO0033.

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L'utilisation récente de grands fragments d'ADN (BACs et YACs) a permis de s'affranchir de " l' effet de position "en transgénèse. Cela a été le cas pour un BAC caprin de 160 kb contenant le gène de l'a-lactalbumine (BAC 41), suggérant la présence d'éléments cis-régulateurs dominants. Mon sujet de thèse visait à analyser plus finement cet insert. Des expériences de transgénèse utilisant un BAC raccourci dérivé (BAC 6) nous a permis d'effectuer une primo-localisation de ces éléments. Dans cette région deux loci ont été identifiés : celui de la cycline T1 et FLJ20436. Leur caractérisation fonctionnelle a permis de montrer qu'ils sont actifs au sein du BAC et à expression ubiquiste. De façon inattendue, l'utilisation du promoteur de la cycline T1 en transgénèse a conduit à unessur-expression dans la lignée germinale mâle. Le gène FLJ20436 présente un épissage complexe. Ces études nous ont amenés à suspecter la présence de deux domaines chromatiniens putatifs séparant ces gènes à expression ubiquiste de celui de l'a-lactalbumine. L'analyse structurale de ces loci a permis de dresser une carte précise du BAC 41 et de délimiter une région frontière séparant les deux domaines chromatiniens putatifs. Une recherche en son sein d'éléments cis-régulateurs dominants a été initiée. L'identification et l'association de tels éléments au promoteur du gène de l'a-lactalbumine devraient contribuer à la mise au point de vecteurs d'expression efficients pour la transgénèse mammaire
The recent use of large genomic fragment (BACs or YACs) has allowed to avoid this "position effect". This has been observed with a vector that was developed in our laboratory that consists of a 160 kb goat BAC insert (BAC 41) encompassing the a-lactalbumin gene, suggesting the occurrence of dominant cis-regulatory elements. The aim of this thesis was to further analyse this insert. Transgenic experiments using a derived shorter BAC of 60 kb allowed us to localise these regulatory elements in a 5' distal region of the a-lactalbumin locus. In this region two loci were identified: the cyclin T1 and FLJ20436. Characterisation of these genes revealed that they were functional within the BAC 41 and ubiquitously expressed. Surprisingly, the use of the cyclin T1 promoter in transgenics resulted in an ubiquitous expression unexpectedly high only in male germ cells. FLJ20436 pre-mRNA has a very complex splicing pattern that is conserved during evolution. These observations led us to suspect the occurrence of two chromatin domains separating these ubiquitously expressed genes from the a-lactalbumin one. Structural analysis of these genes has allowed to define a precise restriction map of the BAC 41 and to precise the location of the potential border region within the two chromatin domains. Search for cis-regulatory elements within this region was initiated. There identification and association with the a-lactalbumin promoter should contribute to the creation of efficient mammary specific expression vectors

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Gramont, Armand de. „Etude de la cycline B2 et caractérisation des variants d'épissage des cyclines B1v et B2v chez l'homme“. Paris 6, 2005. http://www.theses.fr/2005PA066008.

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Bonnet, Christine. „Un motif sur la cycline B nécessaire à l'activation de CDK1 chez la levure ?“ Paris 6, 2002. http://www.theses.fr/2002PA066509.

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Pontheaux, Florian. „Activité traductionnelle et dynamique mitotique induites par la fécondation chez l’oursin“. Electronic Thesis or Diss., Sorbonne université, 2022. http://www.theses.fr/2022SORUS209.

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La régulation fine de la traduction pour la dynamique du cycle cellulaire est un sujet important dans la recherche cellulaire. Au cours de ma thèse, j'ai analysé les relations entre l’activité traductionnelle des ARNm et les divisions embryonnaires mitotiques d'oursins. La fécondation de l'œuf déclenche l'activation de la machinerie traductionnelle nécessaire à la reprise des divisions mitotiques. Un réseau de régulation traductionnelle (TlRN), indépendant de la transcription, reste à identifier et à caractériser en amont des acteurs du cycle cellulaire. A la recherche d'activités mitotiques pour visualiser la dynamique spatiale à l'intérieur d'œufs, j'ai obtenu des données originales montrant l'activité dynamique et spatiale du complexe mitotique CyclinB/CDK1 et la phosphorylation de l'histone H3 sur la thréonine 3 (pH3T3) pendant la mitose embryonnaire. Ensuite, j'ai analysé le rôle in vivo de 5'UTR spécifiques pour contrôler le recrutement d'ARNm dans les polysomes actifs après la fécondation. Enfin, j'ai montré que la traduction de l'ARNm codant pour eIF4B (facteur d'initiation eucaryote 4B) contrôle l'activité traductionnelle et la dynamique des deux premières divisions mitotiques induites par la fécondation. Je propose qu'eIF4B agisse comme un régulateur positif au sein du TlRN. Ces données permettront d'étudier l'effet potentiel d'eIF4B sur les activités CDK1 et pH3T3
Fine tuning of translation for cell cycle dynamics remains an important topic in cell research. During my thesis, I analyzed the relationships between mRNA translational activity and mitotic cell division using sea urchin embryos. Egg fertilization triggers the activation of the translational machinery, which is required for resuming the first mitotic division, independently of any transcription. A Translational Regulatory Network (TlRN) remains to be identified and characterized upstream of the cell cycle actors. Seeking mitotic activities that can help visualize spatial dynamics inside isolated eggs, I obtained original data showing the spatial and dynamic activity of the mitotic complex CyclinB/CDK1 and the phosphorylation of histone H3 at threonine 3 (pH3T3) during embryonic mitosis. Then, I analyzed the in vivo role of specific 5’UTR for controlling the mRNA recruitment onto active polysome following fertilization. Finally, I showed that the translation of the mRNA encoding for eIF4B (eukaryotic Initiation Factor 4B) controls the translational activity and dynamics of the first two mitotic divisions induced by fertilization. I propose that eIF4B acts as a positive regulator within the TlRN. These data will allow to study the potential effect of eIF4B acting upstream the spatial dynamics of CDK1 and pH3T3 activities

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Bockstaele, Laurence. „Réévaluation de la régulation de l'activité de la CDK4, kinase dépendante des cyclines D, clé de l'engagement dans le cycle cellulaire: rôle de l'inhibiteur p27“. Doctoral thesis, Universite Libre de Bruxelles, 2006. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210626.

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La progression à travers le cycle cellulaire est assurée par l’activation séquentielle d’une série de complexes cycline-CDK. Les complexes cycline D-CDK4 assurent la progression au cours de la phase G1 du cycle cellulaire en phosphorylant les protéines « antioncogéniques » de la famille Rb. L’activation de la CDK4 nécessite son association à une cycline D et sa phosphorylation sur Thr172 par la CAK nucléaire (CDK activating kinase). Le rôle essentiel des protéines de la famille Cip/Kip dans la régulation de l’activité de ces complexes reste controversé. Les protéines de cette famille (comprenant p27 et p21) ont initialement été identifiées comme des inhibiteurs puissants des complexes cycline-CDK et comme les intermédiaires de l’action antimitogénique de différents signaux intra ou extra-cellulaires. Il a été proposé que la liaison de la p27 ou de la p21 aux complexes cycline D-CDK4 empêche leur phosphorylation activatrice par la CAK et leur activité pRb kinase. Cependant, l’observation que des complexes cycline D-CDK4 associés à p21/p27 possèdent une activité pRb kinase a donné naissance à une seconde hypothèse sur la régulation de ces complexes par la p27 ou la p21. Ces « inhibiteurs » ont été paradoxalement proposés comme facteurs nécessaires et suffisants d’assemblage et de localisation nucléaire des complexes cycline D-CDK4. Dans le modèle physiologiquement relevant des thyrocytes de chien en culture primaire, la mitogénèse dépendante de l’AMPc activée par la TSH diffère des cascades des facteurs de croissance puisqu’elle n’induit pas les cyclines D mais au contraire augmente l’accumulation de l’«inhibiteur» de CDK p27. L’AMPc stimule l’assemblage des complexes cycline D3-CDK4, leur translocation nucléaire et leur association à p27. Dans ce modèle, le TGF&61538; inhibe la mitogénèse dépendante de l’AMPc en inhibant la translocation nucléaire des complexes cycline D3-CDK4 et leur association à la p27.

Nous avons étudié l’activité catalytique et l’activation des complexes cycline D3-CDK4-p27 issus des thyrocytes de chien en culture primaire ou produits en cellules d’eucaryotes supérieurs (CHO et Sf9). Nous avons pu montrer que les complexes cycline D3-CDK4-p27 issus des thyrocytes de chien stimulés par la TSH présentent une activité pRb-kinase qui est inhibée par le TGF&61538; En outre, la production des complexes cycline D3-CDK4-p27 en cellules CHO ou Sf9 nous a permis de montrer que l’impact de la p27 sur l’activité catalytique des complexes cycline D3-CDK4 dépend de sa stoechiométrie de liaison à ces complexes. L’analyse du profil de séparation par électrophorèse bidimensionnelle de la CDK4 issue de ces trois systèmes montre que la p27 n’empêche pas la phosphorylation activatrice de la CDK4, même aux concentrations de p27 qui empêchent l’activité pRb kinase du complexe cycline D3-CDK4. Nous avons également montré dans les cellules CHO que la p27 détermine la localisation nucléaire des complexes cycline D3-CDK4, ceux-ci étant relocalisés dans le cytoplasme par la transfection d’un mutant de la p27 dépourvu de son signal de localisation nucléaire. Ces résultats valident les observations réalisées par immunofluorescence dans les thyrocytes de chien dans lesquels nous avons mis en évidence une étroite corrélation au niveau des cellules individuelles stimulées par la TSH entre la translocation nucléaire de la CDK4 et l’apparition de la p27 nucléaire. Cette colocalisation est partiellement inhibée par le TGF&61538; Ces observations renforcent l’hypothèse d’un rôle de la p27 dans l’ancrage nucléaire des complexes cycline D3-CDK4.

Alors que la localisation de la CAK est considérée comme exclusivement nucléaire et son activité catalytique constitutive, nous avons pu montrer que la phosphorylation activatrice de la CDK4 associée à la cycline D3 n’est pas affectée par sa localisation sub-cellulaire et qu’elle est régulée par le TGF&61538; dans les thyrocytes de chien et par le sérum dans les cellules T98G indépendamment de l’association de la CDK4 à la p27. De plus, la phosphorylation de la CDK4 sur Thr172 dans les cellules T98G est stimulée par le sérum, alors que la phosphorylation activatrice de la CDK6, son homologue fonctionnel, ne l’est pas. La comparaison de la séquence de ces deux CDKs à proximité des Thr phosphorylées (Thr177 pour la CDK6) révèle, outre une forte similarité de séquence, une différence au niveau de l’acide aminé situé en aval de la thréonine :il s’agit d’une proline dans la CDK4 et d’une sérine dans la CDK6. La mutation P173S de la CDK4 abolit la phosphorylation sur Thr172 et l’activité de la CDK4 associée à la cycline D3 dans les cellules CHO, mais n’affecte pas la phosphorylation et l’activation de la CDK4 par la CAK recombinante in vitro. L’ensemble de ces résultats suggère que la/les CAKs régulée(s) responsables de l’activation de la CDK4 n’ont pas encore été identifiées et que la proline située en aval de la Thr172 de la CDK4 est essentielle pour sa phosphorylation activatrice et son activité pRb kinase.

Doctorat en sciences biomédicales
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Viallard, Jean-François. „Apport de la cytométrie en flux à l'étude des protéines du cycle cellulaire“. Bordeaux 2, 1999. http://www.theses.fr/1999BOR28688.

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Sorrell, David Andrew. „CycD cyclins and cyclin-dependent kinases in tobacco BY-2 cells“. Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624421.

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Delorme, Richard. „Microscopie confocale et cytométrie tridimensionnelle : application à l'étude de la localisation de la cycline A et des CDK associées dans les cellules lymphoïdes“. Lyon 1, 1997. http://www.theses.fr/1997LYO1T239.

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Loncle, Nicolas. „Rôles distincts des sous-unités du module CDK8 du complexe médiateur de la transcription au cours du développement de la drosophile“. Toulouse 3, 2007. http://www.theses.fr/2007TOU30075.

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Bücher zum Thema "CyclineB"

Cycling. Oxford: Heinemann Library, 2010.

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Garrett, Greg. Cycling. New York: Kensington Books, 2003.

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Mason, Paul. Cycling. London: Franklin Watts, 2011.

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North, David. Cycling. London: Flame Tree, 2011.

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Bow, James. Cycling. London: Franklin Watts, 2013.

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W, Darst Paul, Hrsg. Cycling. Glenview, Ill: Scott, Foresman, 1987.

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Bailey, Donna. Cycling. Austin, Tex: Steck-Vaughn Library, 1991.

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Paul, Mason. Cycling. Mankato, Minn: Sea-to-Sea Publications, 2010.

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Bow, James. Cycling. London: Franklin Watts, 2009.

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Cycling. New York: Children's Press, 2000.

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Buchteile zum Thema "CyclineB"

Malumbres, Marcos. „Cyclins and Cyclin-dependent Kinases“. In Encyclopedia of Systems Biology, 509–12. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-9863-7_10.

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Cox, Peter. „Introduction“. In Cycling, 1–10. Abingdon, Oxon ; New York, NY : Routledge, 2019.: Routledge, 2019. http://dx.doi.org/10.4324/9781315533698-1.

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Cox, Peter. „Riding the city“. In Cycling, 174–94. Abingdon, Oxon ; New York, NY : Routledge, 2019.: Routledge, 2019. http://dx.doi.org/10.4324/9781315533698-10.

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Cox, Peter. „Towards a sociology of cycles and cycling“. In Cycling, 11–35. Abingdon, Oxon ; New York, NY : Routledge, 2019.: Routledge, 2019. http://dx.doi.org/10.4324/9781315533698-2.

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Cox, Peter. „Researching cycling“. In Cycling, 36–58. Abingdon, Oxon ; New York, NY : Routledge, 2019.: Routledge, 2019. http://dx.doi.org/10.4324/9781315533698-3.

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Cox, Peter. „Materials“. In Cycling, 59–80. Abingdon, Oxon ; New York, NY : Routledge, 2019.: Routledge, 2019. http://dx.doi.org/10.4324/9781315533698-4.

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Cox, Peter. „Environments“. In Cycling, 81–99. Abingdon, Oxon ; New York, NY : Routledge, 2019.: Routledge, 2019. http://dx.doi.org/10.4324/9781315533698-5.

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Cox, Peter. „Exploring (im)material space“. In Cycling, 100–119. Abingdon, Oxon ; New York, NY : Routledge, 2019.: Routledge, 2019. http://dx.doi.org/10.4324/9781315533698-6.

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Cox, Peter. „Competencies“. In Cycling, 120–39. Abingdon, Oxon ; New York, NY : Routledge, 2019.: Routledge, 2019. http://dx.doi.org/10.4324/9781315533698-7.

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Cox, Peter. „Riding together“. In Cycling, 140–55. Abingdon, Oxon ; New York, NY : Routledge, 2019.: Routledge, 2019. http://dx.doi.org/10.4324/9781315533698-8.

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Konferenzberichte zum Thema "CyclineB"

Srinivas, Y. L., und Debasish Dutta. „Blending and Joining Using Cyclides“. In ASME 1992 Design Technical Conferences. American Society of Mechanical Engineers, 1992. http://dx.doi.org/10.1115/detc1992-0170.

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Abstract We consider the use of cyclides in geometric modeling. These are algebraic surfaces of degree four with interesting properties such as rational parametric forms and closure under offsets. The incorporation of cyclides as primitives in solid modellers will increase their geometric coverage. In this paper, we describe the cyclide and discuss two applications of its use in computer aided design — modeling blending surfaces and the automatic joining of pipes. Implemented examples are also included.

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Gaster, Kristina, und Tina Gebiert. „Mileage-based accident risks of pedelec riders“. In International Cycling Safety Conference. Technische Universität Dresden, 2022. http://dx.doi.org/10.25368/2022.416.

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Francke, Angela, Paul Papendieck, Lisa-Marie Schaefer und Juliane Anke. „Perceived cycling safety during Corona times - Results of a longitudinal study in Germany“. In International Cycling Safety Conference. Technische Universität Dresden, 2022. http://dx.doi.org/10.25368/2022.446.

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Oyoo, Robert O., und S. K. Mwea. „Challenges and Opportunities in Cycling Safety in Nairobi City, Kenya“. In International Cycling Safety Conference. Technische Universität Dresden, 2022. http://dx.doi.org/10.25368/2022.451.

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Tumakova, Yana, Constant Cap, Azeb T. Legese, Marie Klosterkamp und Angela Francke. „“The missing lights of Nairobi” - Cyclists' Perceptions of safety by cycling after-dark in Nairobi, Kenya“. In International Cycling Safety Conference. Technische Universität Dresden, 2022. http://dx.doi.org/10.25368/2022.448.

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Shah, Nitesh R., und Christopher R. Cherry. „Riding an e-scooter at nighttime is more dangerous than at daytime“. In International Cycling Safety Conference. Technische Universität Dresden, 2022. http://dx.doi.org/10.25368/2022.436.

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Ramírez-Leuro, Laura D., und Lenin A. Bulla-Cruz. „Cyclists' Safety and Security Multiple Correspondence Analysis from GPS Records for Route Choice in Bogotá - Colombia“. In International Cycling Safety Conference. Technische Universität Dresden, 2022. http://dx.doi.org/10.25368/2022.447.

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Rubie, Elisabeth, Narelle Haworth und Naohide Yamamoto. „Passing distance, speed and perceived risks to the cyclist and driver in passing events“. In International Cycling Safety Conference. Technische Universität Dresden, 2022. http://dx.doi.org/10.25368/2022.439.

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Legese, Azeb T., Abhimanyu Prakash, Angela Francke, Yana Tumakova, Marie Klosterkamp und Paul Papendieck. „More than a billion motives to focus on NMT Africa - Enhancing the quality of infrastructure to improve cycling safety and cycling culture in Africa, case in Ethiopia“. In International Cycling Safety Conference. Technische Universität Dresden, 2022. http://dx.doi.org/10.25368/2022.450.

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Hagemeister, Carmen, und Leander Bertram. „Frequency and Legitimacy of Aggressive Driver Behaviour against Cyclists when Sharing the Road“. In International Cycling Safety Conference. Technische Universität Dresden, 2022. http://dx.doi.org/10.25368/2022.441.

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Berichte der Organisationen zum Thema "CyclineB"

Lißner, Sven, Stefan Huber und Maike von Harten. Influence of the cycling campaign CITY CYCLING on cycling behaviour in Germany. TU Dresden, Fakultät Verkehrswissenschaften 'Friedrich List', 2023. http://dx.doi.org/10.26128/2023.65.

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The CITY CYCLING (STADTRADELN) campaign has been running since 2008 to motivate German citizens to use the bicycle for daily mobility routines. In the course of the MOVEBIS research project, nationwide GPS data of the CITY CYCLING participants were collected in the years 2018-2020 and were processed for planning purposes. This contribution addresses the question to which extent the participants in the CITY CYCLING campaign represent cyclists in the Federal Republic of Germany and whether the motivation during the campaign leads to a significant change in mobility behaviour. For this purpose, more than 73,000 complete questionnaires of campaign participants from a survey in the year 2020 were evaluated. The age and gender distribution of app users and non-users of the campaign are corresponding to those of cyclists from representative household surveys in Germany (MiD 2017). App users and non app users differ only insignificantly from each other and are, on average, rather older than in the cycling participants of nationwide MiD survey. The results reveal that the smartphone has no significant influence on the cycling behaviour of the users. The survey participants are regular cyclists. Around 88% of the respondents use the bicycle most frequently in everyday life, followed by the private car (national average) and public transport (in large cities). The influence of the campaign on the level of utilisation or the number of kilometres travelled by bike can be described as rather low, overall. Whereas 65% of the participants stated that they cycled to work just as often as outside the campaign period, 19% of the respondents used the bicycle less often for commuting and 16% more often. The results indicate that the CITY CYCLING campaign captures and represents the everyday transport behaviour of participants. During the COVID-19 pandemic, participants used their bicycles significantly more often (73%). The perception of safety is consistently high. The campaign was rated very positively and the majority of users (91%) would participate again or rather recommend the campaign to others (78%).

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Hogan, Eileen, und Becci Jeffers. A sense of freedom: Exploring everyday experiences of cycling in an Irish regional city. Institute for Social Science in the 21st Century, University College Cork, 2023. http://dx.doi.org/10.33178/10468/15138.

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In current policy and planning discourse, there is great interest in reimagining and redesigning cities as more cycling-friendly spaces. Research shows that good cycling infrastructure is the first step to increasing cycling rates. However, social and cultural factors are also important for understanding the attractions of cycling and barriers to cycling but these tend to be under-explored in transport policy and research. In partnership with the Cork Environmental Forum and the Cork Cycling Campaign, this study set out to develop social scientific knowledge about cycling as a social practice, focusing on Cork as a case study of an Irish regional city, with a view to informing pro-cycling policy.

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Rohrer, Lisa, Johannes Lidmo und Christoph Beidenhauser. Nordic cycling policy: National objectives, mechanisms, and actors in Denmark, Finland, Norway, and Sweden. Nordregio, November 2024. http://dx.doi.org/10.6027/wp2023:81403-2511.

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This paper reviews how Nordic countries are working to improving cycling via policy and planning. It takes a national-level approach to review cycling objectives in Denmark, Finland, Norway, and Sweden, reviews a range of mechanisms to achieve these objectives, and identifies the key actors responsible for carrying out the work. In the discussion section, the paper identifies several findings from the review work with regards to how the Nordic countries are currently addressing cycling at the policy level: - Cycling is primarily discussed as a means for contributing to environmental goals, such as GHG emission reductions, but is occasionally discussed as a means for improving health and well-being. Much less policy discourse focuses on economic or other social benefits of cycling. The primary method for reducing GHG emissions in the transportation sector focuses on replacing fossil fuel cars with electric-powered vehicles rather than on cycling infrastructure or spatial forms that decrease overall mobility requirements. - The Nordic countries have some distinctions with regards to how spatial planning is operationalised, which influences how cycling is prioritised and managed. - Beyond a dedicated cycling strategy, cycling objectives are often baked into other key plans and documents at the national level. - Achieving national cycling objectives requires clear communication among local, regional, and national actors and across ministries, agencies, and departments, which is often a challenge. - Political turnover can be a hindrance to gaining support for long-term cycling projects. - There are many different indicators and ways to measure success for cycling objectives in the Nordic countries. The paper also highlights some of the developments taking place at the UN and EU levels, making cycling and its potential for improving cities and regions more visible across international policy.

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JI, June HyeonJeong. Cycling with fireflies. Ames: Iowa State University, Digital Repository, November 2015. http://dx.doi.org/10.31274/itaa_proceedings-180814-1282.

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Peter A. Pryfogle. Nutrient Cycling Study. Office of Scientific and Technical Information (OSTI), September 2005. http://dx.doi.org/10.2172/966178.

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Kachadoorian, Carol. Cycling Past 50: A Closer Look into the World of Older Cyclists, Year 4 Survey. Mineta Transportation Institute, Dezember 2023. http://dx.doi.org/10.31979/mti.2023.2157.1.

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This document reports on approximately 5,000 responses to a North American survey of older adults who cycle. The survey, open from August 2021 through March 2022, included questions that captured a person’s cycling over their life course, as well as their current cycling styles, habits, and preferences. Responses reflect the impact of various factors on an older adult’s cycling habits with respect to their ability and agility and their expectation to continue cycling. The survey asked about falls and near misses in the past-year coding fall descriptions into six categories and sorting them by the respondent’s gender and age. The survey’s Visual Preference questions offered photos of cycling contexts and asked respondents to select four to six options for traveling within each context, then scored its safety and comfort level between 1 and 5. Key takeaways include: many older adults can continue to cycle as they age by using a different bicycle, establishing a different expectation with regard to cycling, finding others to cycle with, and using safe and comfortable cycling facilities. Survey questions about e-bikes, adult trikes, and tandems show the variety of bicycle types available, but point to the need for higher-capacity bikeways and education about sharing bikeways safely. The report ends with several issues for further consideration, including risks for older cyclists of color, ways that caregiving can enhance or reduce cycling benefits, and how injury recovery can affect a return to cycling, or not. The population of older adults is growing, and examining the needs of this group ensures a community’s ability to create environments conducive to equitable mobility for all.

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Peggs, Stephen, und Michael Furey. Rapid Cycling Medical Synchrotron. Office of Scientific and Technical Information (OSTI), Juli 2007. http://dx.doi.org/10.2172/973828.

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Kumar, Nikil, Philip Besuner, Steven Lefton, Dwight Agan und Douglas Hilleman. Power Plant Cycling Costs. Office of Scientific and Technical Information (OSTI), Juli 2012. http://dx.doi.org/10.2172/1046269.

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Davoudi Kakhki, Fatemeh, und Maria Chierichetti. Exploring the Relationship Between Mandatory Helmet Use Regulations and Adult Cyclists’ Behavior in California Using Hybrid Machine Learning Models. Mineta Transportation Institute, Oktober 2021. http://dx.doi.org/10.31979/mti.2021.2024.

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In California, bike fatalities increased by 8.1% from 2015 to 2016. Even though the benefits of wearing helmets in protecting cyclists against trauma in cycling crash has been determined, the use of helmets is still limited, and there is opposition against mandatory helmet use, particularly for adults. Therefore, exploring perceptions of adult cyclists regarding mandatory helmet use is a key element in understanding cyclists’ behavior, and determining the impact of mandatory helmet use on their cycling rate. The goal of this research is to identify sociodemographic characteristics and cycling behaviors that are associated with the use and non-use of bicycle helmets among adults, and to assess if the enforcement of a bicycle helmet law will result in a change in cycling rates. This research develops hybrid machine learning models to pinpoint the driving factors that explain adult cyclists’ behavior regarding helmet use laws.

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Krantz, F. M., und M. W. Richter. Mission/Maintenance/Cycling Effects on Reliability. Fort Belvoir, VA: Defense Technical Information Center, Dezember 1991. http://dx.doi.org/10.21236/ada251921.

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