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Yamashina, Takeshi, Manabu Fukuhara, Takanori Maruo, Gensho Tanke, Saiko Marui, Ryota Sada, Mio Taki et al. „Cold snare polypectomy reduced delayed postpolypectomy bleeding compared with conventional hot polypectomy: a propensity score-matching analysis“. Endoscopy International Open 05, Nr. 07 (23.06.2017): E587—E594. http://dx.doi.org/10.1055/s-0043-105578.
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Abstract Background and study aims Cold snare polypectomy (CSP) for small colorectal polyps has lower incidence of adverse events, especially delayed postpolypectomy bleeding (DPPB). However, few data are available on comparisons of the incidence of DPPB of CSP and hot polypectomy (HP). The aim of this study was to evaluate the incidence of DPPB after CSP and compare it with that of HP. A propensity score model was used as a secondary analysis. Patients and methods This was a retrospective cohort study conducted in a single municipal hospital. We identified 539 patients with colorectal polyps from 2 mm to 11 mm in size who underwent CSP (804 polyps in 330 patients) or HP (530 polyps in 209 patients) between July 2013 and June 2015. Results There were no cases of DPPB in the CSP group. Conversely, DPPB occurred in 4 patients (1.9 %) after HP, resulting in a significant difference between the CSP and HP groups (0.008 % vs 0 %, P = 0.02). Propensity score-matching analysis created 402 matched pairs, yielding a significantly higher DPPB rate in the HP group than CSP group (0.02 % vs 0 %, P = 0.04). However, significantly more patients in the CSP group had unclear horizontal margins that precluded assessment (83 vs 38 cases, P < 0.001). The retrieval failure rate was significantly higher in the CSP group than in the HP group (3 % vs 0.7 %, P = 0.01). Conclusions DPPB was less frequent with CSP than HP, as selected by the propensity score-matching model. Our findings indicate that CSP is recommended polypectomy in daily clinical setting. However, special care should be taken during polyp retrieval and horizontal margin assessment, and these issues could be taken into account in follow-up after CSP.
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Ben Lahouel, Béchir, Jean-Marie Peretti und David Autissier. „Stakeholder power and corporate social performance“. Corporate Governance 14, Nr. 3 (27.05.2014): 363–81. http://dx.doi.org/10.1108/cg-07-2012-0056.
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Purpose – This paper aims to explore the power of one of the primary organizational stakeholders (shareholders) in the development of a corporate social performance (CSP) score. Few research works in the CSP empirical literature have studied the relationship between stakeholder power and CSP. Design/methodology/approach – Stakeholder theory is used as a theoretical framework to explain how shareholder voting power can influence the CSP level of French publicly listed companies. Stakeholder theory is tested through the operationalization of Ullmann’s (1985) three-dimensional model. Hypotheses related to shareholder voting power, strategic posture and financial performance are formulated through a literature review. A Data Envelopment Analysis approach was presented as a strong tool to measure CSP level. Multiple linear regressions were undertaken to test the hypotheses in a sample of 129 French companies between 2006 and 2007. Findings – The results indicate that companies with dispersed ownership and high proportion of institutional shareholders record a high score of CSP. Strategic posture measured by the implementation of environmental certification standard was positively and significantly related to CSP. Financial performance does not affect significantly the level of CSP. Originality/value – This paper is the first to empirically analyse the relationship between Ullmann’s three-dimensional model and CSP level in the French context. It offers to managers a better understanding of the power that certain stakeholders can use to acquire satisfaction.
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Wei, Qing Guo, Bin Wan und Zong Wu Lu. „Classification of EEG Signals Using Filter Bank Common Spatial Pattern Based on Fisher and Laplacian Criteria“. Applied Mechanics and Materials 239-240 (Dezember 2012): 1033–38. http://dx.doi.org/10.4028/www.scientific.net/amm.239-240.1033.
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Common spatial pattern (CSP) is a highly successful algorithm in motor imagery based brain-computer interfaces (BCIs). The performance of the algorithm, however, depends largely on the operational frequency bands. To address the problem, a filter bank was applied to find optimal frequency bands. In filter bank, CSP was applied in all sub-band signals for feature extraction. The feature selection is the key of filter bank method for increasing classification performance. In this study, coefficient decimation (CD) technique was used to devise filter bank, while Fisher score and Laplacian score were proposed as feature selection criterion. In off-line analysis, the proposed method yielded relatively better cross-validation classification accuracies.
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Kyaw, Khine, Mojisola Olugbode und Barbara Petracci. „Can board gender diversity promote corporate social performance?“ Corporate Governance: The International Journal of Business in Society 17, Nr. 5 (02.10.2017): 789–802. http://dx.doi.org/10.1108/cg-09-2016-0183.
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Purpose This paper examines if gender diversity on corporate boards promotes corporate social performance (CSP) across industries and across countries. Design/methodology/approach Fixed-effect panel models are estimated using Europe-wide data from 2002 through 2013. Instrumental variable estimation and propensity score matching are also used to control for potential endogeneity. Findings Board gender diversity (BGD) improves environmental and social performance and consequently the CSP. Although the positive effect of gender diversity is prevalent across industries, the effect is more pronounced for firms in emerging markets. Practical implications The findings suggest that gender law that fosters gender diversity can promote CSP in firms, and the benefit can be enjoyed with just an introduction of one female director to the board. Promotion of gender diversity in Europe is most beneficial in emerging markets. Originality/value The results provide new insights to the literature, as we find that a critical mass of female directors on boards is not required to promote CSP. The research also highlights that BGD enhances CSP irrespective of the industry, and the effect on CSP is more pronounced in emerging markets where regulations regarding CSR are not so clear-cut.
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Preston, K. R., K. J. Quail, S. Zounis und P. W. Gras. „No-time dough baking performance and mixing properties of Canadian Red Spring wheat cultivars using Canadian and Australian test procedures“. Australian Journal of Agricultural Research 48, Nr. 5 (1997): 587. http://dx.doi.org/10.1071/a96113.
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The mixing properties and baking performance of 17 Canada Western Red Spring wheat varieties and advanced breadwheat lines grown under the same environmental conditions have been assessed using Canadian and Australian test bake procedures with emphasis on no-time dough processes. Mixing times with the Australian rapid dough process (RDP) were considerably shorter than those obtained with the Canadian short process (CSP). However, a very high correlation was obtained for mixing time with the RDP and the CSP, indicating a similar ability to rank cultivar bake mixing requirements. Dough development times obtained from normal and high speed (180 rpm) farinograms and micro-mixograms were found to be poor predictors of CSP and RDP mixing time. Cultivars generally showed good to excellent baking performance with the 2 no-time procedures (RDP and CSP) and the Australian fermented dough procedure (FDP). High correlations and similar cultivar rankings were obtained for loaf volume and bread score with the CSP and FDP. However, no significant correlations and different cultivar rankings were obtained between RDP and CSP (or FDP), indicating that different quality properties may determine relative cultivar baking performance. These results also suggest that both no-time dough procedures may be required in breeder selection and quality monitoring programs to ensure superior breadwheat performance in domestic and export markets.
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Suzery, Meiny, Bambang Cahyono und Nur Dina Amalina. „Citrus sinensis (L) Peels Extract Inhibits Metastasis of Breast Cancer Cells by Targeting the Downregulation Matrix Metalloproteinases-9“. Open Access Macedonian Journal of Medical Sciences 9, B (27.06.2021): 464–69. http://dx.doi.org/10.3889/oamjms.2021.6072.
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Introduction:
Long-term use of doxorubicin (DOX) chemotherapy causes several side effects, especially induction of metastasis on breast cancer (BC). There is an urgent need to identify novel agent with low side effect targeting BC metastasis. Citrus sinensis (L.) peels extract (CSP) has long been used for the treatment of several cancer. However, its anti-metastatic potential against BC metastatic remains unclear.
Objective:
This study aimed to explore the role of CSP in combination with DOX in inhibiting the migration of metastatic breast cancer MDAMB-231 cells.
Material and Methods:
Potential cytotoxic in single and combination was analysed 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT assay). The anti-metastatic activities of several major compound on CSP including hesperetin, tangeretin, nobiletin, naringenin and hesperidin were screened by molecular docking under PLANTS software.
Results:
Based on molecular docking we revealed that the selected protein target MMP-9 (PBD ID:2OVX) has lower docking score for hesperetin, tangeretin, nobiletin, naringenin and hesperidin compare to DOX. CSP and DOX individually exhibited strong cytotoxic effect on MDA-MB-231 cells under MTT assay with IC50 value of 344 µg/mL and 85 nM, respectively. Furthermore, CSP in combination with DOX synergistically increased the cytotoxicity of DOX. Here, we showed that CSP can specifically suppress the side effect of DOX-induced metastasis by reduces doses of DOX. However, low doses of DOX in combination with CSP still potential inhibited cancer cells growth.
Conclusion:
In conclusion, CSP increased the cytotoxicity and inhibited the induction of metastasis by DOX in breast cancer cells. So that, CSP potential to be developed as co-chemotherapeutic agent.
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Laskar, Najul, und Santi Gopal Maji. „Disclosure of corporate sustainability performance and firm performance in Asia“. Asian Review of Accounting 26, Nr. 4 (03.12.2018): 414–43. http://dx.doi.org/10.1108/ara-02-2017-0029.
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Purpose The purpose of this paper is to examine the disclosure pattern of corporate sustainability (CS) and the influence of sustainability reporting on firm performance of four countries in Asia – Japan, South Korea, Indonesia and India. Design/methodology/approach The authors have collected the sustainability reports and annual reports of 111 firms from four Asian countries for a period of six years. Based on the framework of Global Reporting Initiatives (GRI, 3 and 3.1), content analysis is used for calculating the disclosure score of corporate sustainability performance (CSP). These scores are further used to examine the impact on firm performance by employing a panel data regression model. Findings The study finds that the average level and quality of disclosure are the highest for Japanese firms, followed by India and South Korea. However, in the case of Indonesia, the average score is very low. Further, the study finds a significant difference in the disclosure of overall sustainability as well as components of sustainability between the countries. The regression results indicate the positive impact of CSP (both in terms of level and quality) on MBR. Specifically, the outcome of the regression model reveals that both the level and quality disclosure of CS are crucial for enhancing firm value for both the developed and developing countries of Asia. Moreover, the relative influence of CSP (both in terms of level and quality) on firm performance is found to be more in developed countries than the developing countries of Asia. Originality/value This is the first comprehensive study in the Asian context to investigate the disclosure pattern of CSP and also examine the association between CSP and firm performance by employing the panel data model. The outcome of this study is useful for policy implication.
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Ustohal, Libor, Michaela Mayerova, Veronika Hublova, Hana Prikrylova Kucerova, Eva Ceskova und Tomas Kasparek. „Risperidone increases the cortical silent period in drug-naive patients with first-episode schizophrenia: A transcranial magnetic stimulation study“. Journal of Psychopharmacology 31, Nr. 4 (20.08.2016): 500–504. http://dx.doi.org/10.1177/0269881116662650.
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Objectives: Schizophrenia is accompanied by impaired cortical inhibition, as measured by several markers including the cortical silent period (CSP). It is thought that CSP measures gamma-aminobutyric acid receptors B (GABAB) mediated inhibitory activity. But the mutual roles of schizophrenia as a disease and the drugs used for the treatment of psychosis on GABA mediated neurotransmission are not clear. Methods: We recruited 13 drug-naive patients with first-episode schizophrenia. We used transcranial magnetic stimulation to assess CSP prior to initiating risperidone monotherapy and again four weeks later. At the same time, we rated the severity of psychopathology using the Positive and Negative Syndrome Scale (PANSS). Results: We obtained data from 12 patients who showed a significant increase in CSP, from 134.20±41.81 ms to 162.95±61.98 ms ( p=0.041; Cohen’s d=0.544). After the treatment, the PANSS total score was significantly lower, as were the individual subscores ( p<0.05). However, no correlation was found between ΔCSP and ΔPANSS. Conclusion: Our study in patients with first-episode schizophrenia demonstrated an association between risperidone monotherapy and an increase in GABAB mediated inhibitory neurotransmission.
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KIM, Hyun-Soo, Su Young Kim und Jung Kuk Lee. „Preventive effects of gender and metabolic syndrome in 40s on colorectal cancer by colonoscopy.“ Journal of Clinical Oncology 38, Nr. 4_suppl (01.02.2020): 59. http://dx.doi.org/10.1200/jco.2020.38.4_suppl.59.
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59 Background: This study was aimed at measuring the preventive effect of colonoscopy for CRC development depending on age of index colonoscopy, gender and metabolic syndrome among persons aged 40 to 59 years. Methods: Between January 2005 and December 2006, data for the population aged from 40 to 59 who underwent colonoscopy (CSP cohort) claimed were collected from National Health Insurance Service (NHIS). Non-CSP (N-CSP) subjects were also collected by 1:5 propensity score matching with parameters of age, sex, and metabolic profiles, smoking, alcohol and past history of cancer. After one year of washout period, the risk of developing CRC was estimated by the occurrence of new case from January 2009 to December 2014 using the link of National CRC Registry to NHIS database. Compared with N-CSP cohort, hazard ratios (HRs) were obtained via conditional logistic regression analysis to estimate the risk of CRC in CSP cohort by age groups. Results: A total of 2,339,359 subjects were included (CSP cohort: 395,738 and matched N-CSP cohort: 1,943,621). The HRs for developing CRC by ages of 40-44, 45-49, 50-54, and 55-59 years in a CSP cohort were 0.864 ( P = NS), 0.591 ( P < 0.001), 0.599 ( P < 0.001), and 0.524 ( P < 0.001) in men, and 0.774 ( P = NS), 0.841 ( P = NS), 0.598 ( P < 0.001), and 0.605 ( P < 0.001) in women, respectively. Interestingly, when confined to patients with metabolic syndrome in their 40s, HRs for CRC in the colonoscopy cohort were statistically significantly lowered to 0.372 in early 40’s and 0.386 in men of late 40s, respectively, but not in women of 40s. Conclusions: The CRC prevention effect of colonoscopy is expected from late 40s in men and early 50s in women. Furthermore, in cases with metabolic syndrome, the preventive effect of colonoscopy is expected in men of early forties.
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Wu, Charlotte, Wade M. Bannister, Hungching Chan, Pam Schumacker, Michael W. Rosen, Kelly L. Blair und Arthur H. Rossof. „How effective is telephonic case management of cancer patients undergoing active therapy?“ Journal of Clinical Oncology 31, Nr. 15_suppl (20.05.2013): e17519-e17519. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e17519.
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e17519 Background: The Cancer Support Program (CSP) of Optum provides patients and their caregivers with telephonic case management by experienced oncology nurses, social workers and appropriately-trained physicians. Goals include reducing emergency department visits and hospitalizations, and helping patients comply with treatments and more effectively manage symptoms. The intent of this study is to evaluate the effectiveness of CSP from both quality and financial perspectives. Methods: The study used a case control approach to compare participants and non-participants of the Optum CSP program. Propensity score method was applied to adjust for baseline differences between the two groups. The study population consisted of cancer patients (N=8,833) enrolled in commercial health plans through self-insured employers. The patients were referred into CSP between July 2009 and June 2011. Outcomes of cost and hospice days were estimated with generalized linear models. We also compared the group of CSP participants (N=3,716) to active cancer patients enrolled in a general CM program (N=2,867) on the topics the nurses discussed with patients. Results: For program participants who were under active treatment and survived at least 6 months after referral , medical cost per patient per month during the six month of engagement was reduced by 9.8% (95% confidence interval [3.7%, 15.6%], p-value 0.002). The decedent’s cost during the last 3 months of the life was reduced by 19.9% (95% confidence interval [2.8%, 34.1%], p-value 0.025). Average hospice days of all deceased CSP participants increased by 42.3%, (95% confidence interval [13.9%, 77.8%], p-value 0.002). CSP nurses, all of whom had cancer management experience, addressed 56 topics of cancer-related support compared to only 11 for general CM nurses. Among the topics that both groups addressed, 35% of the topics were addressed 10% or more frequently by CSP nurses, including “Cancer Treatment Choices Outlined” and “Education Provided: Cancer Medications” etc. Conclusions: We conclude the Optum CSP program is effective in reducing medical cost, promoting use of hospice and providing cancer-specific patient support for a population of cancer patients under active treatment.
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Oltramari, C. E., G. G. O. Nápoles, M. R. De Paula, J. T. Silva, M. P. C. Gallo, M. C. Soares und C. M. M. Bittar. „Performance and metabolism of dairy calves fed starter feed containing citrus pulp as a replacement for corn“. Animal Production Science 58, Nr. 3 (2018): 561. http://dx.doi.org/10.1071/an14851.
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The aim of the present study was to evaluate the effect of replacing corn grain with citrus pulp (CSP) in the starter concentrate on performance and metabolism of dairy calves. Twenty-four individually housed Holstein calves were blocked according to birth date and weight and fed one of the following concentrates: (1) concentrate containing 64% corn and 0% CSP (0CSP); (2) concentrate containing 32% corn and 32% CSP (32CSP); and (3) concentrate containing 0% corn and 64% CSP (64CSP). Animals were fed 4 L of milk replacer daily (20% crude protein, 16% ether extract) divided in two meals (at 0700 hours and 1800 hours). The starter feed and water were provided ad libitum. Starter intake and faecal score were monitored daily. Bodyweight and measurements (withers height, hip width and heart girth) were recorded weekly. Blood samples were collected weekly, and ruminal fluid samples at 4, 6 and 8 weeks of age, 2 h after the morning feeding. After 8 weeks, animals were harvested to evaluate the development of the proximal digestive tract. Concentrate composition had no effect (P > 0.05) on concentrate intake, weight gain, bodyweight, body measurements, and faecal score. However, there was a lower concentration of ruminal butyrate (P < 0.05) in animals receiving 0CSP than in those fed the starter containing CSP. The 0CSP concentrate resulted in a lower (P < 0.05) total weight of the proximal digestive tract, weight of the reticulum–rumen and weight of the omasum than did the other concentrates. The length of the rumen papillae was the greatest (P < 0.05) in 32CSP-fed animals. However, papillae area in animals fed 32CSP concentrate was larger (P < 0.05) than that in 0CSP- and 64CSP-fed animals, with no difference observed between these latter two treatments. However, 0CSP-fed animals showed a higher proportion of abomasum than did the animals fed 32CSP and 64CSP concentrates. The replacement of 50% or 100% of corn by CSP in the starter feed of dairy calves did not affect performance and probably contributed to the better development of the proximal digestive tract.
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Xiong, Xi, Chun-yan Gao, De-mei Ying, Ping Yan, Zhi-jia Zhang, Na Kuang, Hong-ju Tian, Li Luo, Shu-yu Long und Zheng-qiong Chen. „Contrast-Enhanced Ultrasound Evaluation of Mifepristone for Treatment of Low-Risk Cesarean Scar Pregnancy“. Contrast Media & Molecular Imaging 2020 (31.10.2020): 1–6. http://dx.doi.org/10.1155/2020/3725353.
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Purpose. The effect of mifepristone for treatment of low-risk cesarean scar pregnancy (CSP) was monitored by contrast-enhanced ultrasound (CEUS). Methods. Data were collected from 23 CSP patients with a 10-point risk score <5 (low-risk CSP) and from 23 intrauterine pregnancy (IUP) patients with a scar from a previous cesarean delivery. All patients were prescribed 75 mg mifepristone daily for 2 days and underwent transvaginal CEUS before and after administration of mifepristone. On the third day, uterine curettage was performed after transvaginal CEUS. Arrival time (AT), peak intensity (PI), and area under the curve (AUC) around the gestational sac were monitored by CEUS before and after application of mifepristone, and the rate of effective treatment was compared between the two patient groups. Results. No patients experienced side effects from either the CEUS procedure or the mifepristone treatment. Changes in AT, PI, and AUC index from before vs. after mifepristone treatment did not differ significantly between the two groups (all p values >0.05). There was also no significant difference in the rate of effective treatment between the two groups (95.65% in the CSP group vs. 100% in the IUP group; p > 0.05 ). Conclusions. Based on monitoring by CEUS, the effect of mifepristone in low-risk CSP was comparable to that in IUP.
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Jin, Jing, Hua Fang, Ian Daly, Ruocheng Xiao, Yangyang Miao, Xingyu Wang und Andrzej Cichocki. „Optimization of Model Training Based on Iterative Minimum Covariance Determinant In Motor-Imagery BCI“. International Journal of Neural Systems 31, Nr. 07 (26.06.2021): 2150030. http://dx.doi.org/10.1142/s0129065721500301.
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The common spatial patterns (CSP) algorithm is one of the most frequently used and effective spatial filtering methods for extracting relevant features for use in motor imagery brain–computer interfaces (MI-BCIs). However, the inherent defect of the traditional CSP algorithm is that it is highly sensitive to potential outliers, which adversely affects its performance in practical applications. In this work, we propose a novel feature optimization and outlier detection method for the CSP algorithm. Specifically, we use the minimum covariance determinant (MCD) to detect and remove outliers in the dataset, then we use the Fisher score to evaluate and select features. In addition, in order to prevent the emergence of new outliers, we propose an iterative minimum covariance determinant (IMCD) algorithm. We evaluate our proposed algorithm in terms of iteration times, classification accuracy and feature distribution using two BCI competition datasets. The experimental results show that the average classification performance of our proposed method is 12% and 22.9% higher than that of the traditional CSP method in two datasets ([Formula: see text]), and our proposed method obtains better performance in comparison with other competing methods. The results show that our method improves the performance of MI-BCI systems.
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Aoi, Michikazu, Shigeru Asaba, Keiichi Kubota und Hitoshi Takehara. „Family firms, firm characteristics, and corporate social performance“. Journal of Family Business Management 5, Nr. 2 (12.10.2015): 192–217. http://dx.doi.org/10.1108/jfbm-08-2013-0019.
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Purpose – The purpose of this paper is to explore corporate social performance attained by listed family and non-family firms in Japan. They are measured by the composite CSP index and five attributes composed of employ relations, social contributions (SCs), firm security and product safety, internal governance and risk control, and environment concern. Design/methodology/approach – The authors employ univariate and regression analyses on the quantitatively aggregated CSP score data of Japanese firms from 2007 to 2009. Findings – Japan non-family firms tend to perform better than family firms in terms of attaining corporate social performance overall. Family CEOs positively affect CSP in the foods, textiles and apparels, and pharmaceutical industries as well as in retail trade, wholesale, and services industries, but negatively affect CSP in the heavy manufacturing industry. In these industries the joint effect of the percentage of family shareholdings and the fraction of family members on the board also augments the positive role played by family CEO. The findings are robust when the sample is ranked by Tobin’s q. Research limitations/implications – The observation period is short due to the data availability of CSP by Toyo Keizai Inc. This data covers all the listed firms which answered the questionnaire, which may also contain sample selection problems. Practical implications – Positive role of CEO and negative effects of shareholdings among listed family firms in Japan call for attention and corrective measures for top management and family shareholders. Social implications – While family firms in Japan may accumulate socioemotional wealth, they should exert more efforts to advance CSP and create social capital. Originality/value – This is the first comprehensive quantitative study in the field, which explored CSP of all the listed family firms vs non-family firms in Japan with large sample.
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Ren, Dong, Yueju Liu, Yanxi Chen, Jian Lu, Zhaohui Song, Bing Zhou und Pengcheng Wang. „A Novel Method of the Treatment for Posterolateral Tibial Plateau Fractures“. Journal of Knee Surgery 33, Nr. 10 (24.05.2019): 1010–19. http://dx.doi.org/10.1055/s-0039-1688918.
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AbstractReduction and fixation of posterolateral tibial plateau fracture via a posterolateral approach is challenging, and the posterolateral approach itself may injure the posterolateral ligament complex of the knee and can result in knee instability. We developed a new curved support plate (CSP) that can pass, via traditional anterolateral approach, through the superior tibiofibular interval and effectively support the posterolateral fragments. The purpose of our study was to determine the biomechanical reliability of the new plate and report the preliminary efficacy of the CSP for posterolateral tibial plateau fracture. In the biomechanical experiment, 40 synthetic tibias were used to create posterolateral shearing tibial fracture models, which were randomly assigned to groups A to D. Vertical displacement of the posterolateral fragments was measured under axial loads of 500 to 1,500 N. The new plate and 3.5-mm lateral locking plate exhibited similar control over fragment displacement. From June 2016 to August 2017, eight patients with posterolateral tibial plateau fracture underwent treatment with the CSP. Hospital for Special Surgery (HSS) knee score, knee flexion and extension ranges of motion, and complications were recorded to evaluate treatment effects. Eight patients (five men and three women, mean age 44 years [range, 23–66 years]) were enrolled in the study. Mean follow-up time was 13 months (range, 7–19 months). All patients achieved radiographic bone union by 3.3 months (range, 3–4 months) postoperatively. There were no complications of neurovascular injury, deep vein thrombosis, infection, and implant loosening throughout the follow-up period. At final follow-up, mean HSS score was 92.6 (88–96), with a mean knee flexion of 131.25 degrees (120–135 degrees) and a mean knee extension of 1 degree (0–5 degrees). Fixation of posterolateral tibial plateau fracture was easily and successfully achieved using our newly designed CSP, which may provide a new choice for posterolateral tibial plateau fractures.
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Wu, Charlotte, Wade M. Bannister, Michael W. Rosen, Pam Schumacker und Arthur H. Rossof. „How effective is telephonic case management of patients with cancer?“ Journal of Clinical Oncology 31, Nr. 31_suppl (01.11.2013): 254. http://dx.doi.org/10.1200/jco.2013.31.31_suppl.254.
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254 Background: Case management offers the opportunity to improve quality of cancer care but the financial impact is largely unknown. Optum’s Cancer Support Program (CSP) provides patients and their caregivers with telephonic case management services which are focused on reducing emergency department visits and hospitalizations, and helping patients comply with treatments and more effectively manage symptoms related to their disease or to its treatment. This study evaluates the effectiveness of CSP primarily from financial perspectives. Methods: The study used a case control approach to compare participants and non-participants of the Optum CSP program. The propensity score method was applied to adjust for baseline differences between the two groups. The study population consisted of cancer patients (N=8,833) enrolled in commercial health plans through self-insured employers. The patients were referred to CSP between July 2009 and June 2011. Analyses were conducted for survivors and decedents separately to account for mortality bias. Outcomes of cost and hospice days were estimated with generalized linear models. Results: For program participants who were under active treatment and survived at least 6 months after referral, cancer-related medical cost per patient per month during the six months of follow up was reduced by 9.8% (95% confidence interval [3.7%, 15.6%], p-value 0.002), and almost 60% of the cost savings were from inpatient admissions. The decedent’s cost during the last 3 months of the life was reduced by 19.9% (95% confidence interval [2.8%, 34.1%], p-value 0.025), and more than 80% of the cost savings were from inpatient admissions. The average hospice days of all deceased CSP participants increased by 42.3%, (95% confidence interval [13.9%, 77.8%], p-value 0.002). Conclusions: We conclude the Optum CSP program is effective in reducing medical cost among both cancer survivors under active treatment and those who did not survive, while promoting hospice utilization during end-of-life.
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Yan, Chao-Qun, Jian-Wei Huo, Xu Wang, Ping Zhou, Ya-Nan Zhang, Jin-ling Li, Mirim Kim et al. „Different Degree Centrality Changes in the Brain after Acupuncture on Contralateral or Ipsilateral Acupoint in Patients with Chronic Shoulder Pain: A Resting-State fMRI Study“. Neural Plasticity 2020 (25.04.2020): 1–11. http://dx.doi.org/10.1155/2020/5701042.
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Chronic shoulder pain (CSP) is the third most common musculoskeletal problem. For maximum treatment effectiveness, most acupuncturists usually choose acupoint in the nonpainful side, to alleviate pain or improve shoulder function. This method is named opposite needling, which means acupuncture points on the right side are selected for diseases on the left side and vice versa. However, the underlying neural mechanisms related to treatment are currently unclear. The purpose of this study was to determine whether different mechanisms were observed with contralateral and ipsilateral acupuncture at Tiaokou (ST 38) in patients with unilateral CSP. Twenty-four patients were randomized to the contralateral acupuncture group (contra-group) and the ipsilateral acupuncture group (ipsi-group). The patients received one acupuncture treatment session at ST 38 on the nonpainful or painful sides, respectively. Before and after acupuncture treatment, they underwent functional magnetic resonance scanning. The treatment-related changes in degree centrality (DC) maps were compared between the two groups. We found alleviated pain and improved shoulder function in both groups, but better shoulder functional improvement was observed in the contra-group. Increased DC in the anterior/paracingulate cortex and decreased DC in bilateral postcentral gyri were found in the contra-group, while decreased DC in the bilateral cerebellum and right thalamus was observed in the ipsi-group. Furthermore, the DC value in the bilateral anterior/paracingulate cortex was positively correlated with the treatment-related change in the Constant–Murley score. The current study reveals different changes of DC patterns after acupuncture at contralateral or ipsilateral ST 38 in patients with CSP. Our findings support the hypothesis of acupoint specificity and provide the evidence for acupuncturists to select acupoints for CSP.
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Molsberger, AF. „Does Acupuncture Contribute to the Treatment of Chronic Shoulder Pain (Csp)“. Acupuncture in Medicine 20, Nr. 2-3 (August 2002): 122–38. http://dx.doi.org/10.1136/aim.20.2-3.122.
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Objective Response of Chinese acupuncture compared to conservative orthopaedic treatment and unspecific needling in pain treatment on CSP. Design Prospective, randomized controlled trial with three blinded parallel groups; follow up three months. Setting Outpatients of 26 orthopaedists, who have attended a 140 hours training course on acupuncture. Patients Four hundred and twenty seven out-patients with a history of CSP ≥ six weeks, VAS ≥ 50 mm were selected; three random groups, six weeks treatment. 308 patients reported after three months follow up. Two strata: age 25–45 and age 46–65. Interventions Group 1: VAP: 15 treatments of verum acupuncture (VAP). Group 2: SHM: 15 treatments of non-specific needling, sham acupuncture (SHM). Group 3: COT: conventional conservative orthopaedic treatment (COT). Patients were blinded to allocation between verum and sham acupuncture. Main Outcome Measures Primary endpoint: pain reduction ≥ 50% on VAS three months after the end of the treatment protocol. Secondary endpoints: global assessments on a 4-score scale directly after the end of the treatment protocol. Results The results after three months follow up are: Highly significant effect of CAP over SHM and COT in the whole sample (P<0.0001) and in Stratum1 (P<0.001) and Stratum2 (P<0.001). Conclusions Acupuncture is an important supplement in the management of CSP. BMBF grant: 01KT9411/9
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Laskar, Najul, und Santi Gopal Maji. „Corporate sustainability reporting practices in India: myth or reality?“ Social Responsibility Journal 12, Nr. 4 (03.10.2016): 625–41. http://dx.doi.org/10.1108/srj-05-2015-0065.
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Purpose The purpose of this paper is to look into the sustainability practices of Indian firms in terms of the quality of disclosure, the impact of corporate sustainability performance (CSP) on firm performance and the appropriateness of the sustainability reporting guidelines followed by the firms. Design/methodology/approach The present study is based on secondary data collected from annual reports and corporate sustainability reports of 28 listed Indian non-financial firms from 2008-2009 to 2013-2014. Content analysis is used to calculate the score in terms of level (binary coding system) and quality of disclosure (four-point scale). These scores are further used to examine the impact of CSP on firm performance by using an appropriate regression model. Findings The study finds that the average level of disclosure is 88 per cent, whereas the quality of disclosure is nearly 80 per cent. The influence of CSP (in terms of level and quality disclosure) on firm performance is positive and significant. Moreover, the study also reveals that the Global Reporting Initiatives framework is not sufficient enough to publish the sustainability report of any business concern. The outcomes of the study, thus, indicate that sustainability practices of Indian firms are not myth but approaching toward reality. Originality/value It is the first comprehensive study in India to analyze the corporate sustainability reporting practices encompassing different dimensions of sustainability.
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Wang, Jin, und Qingguo Wei. „Classification of EEG Signals Based on Filter Bank and Sparse Representation in Motor Imagery Brain-Computer Interfaces“. Journal of Circuits, Systems and Computers 29, Nr. 03 (20.05.2019): 2050034. http://dx.doi.org/10.1142/s0218126620500346.
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To improve the classification performance of motor imagery (MI) based brain-computer interfaces (BCIs), a new signal processing algorithm for classifying electroencephalogram (EEG) signals by combining filter bank and sparse representation is proposed. The broadband EEG signals of 8–30[Formula: see text]Hz are segmented into 10 sub-band signals using a filter bank. EEG signals in each sub-band are spatially filtered by common spatial pattern (CSP). Fisher score combined with grid search is used for selecting the optimal sub-band, the band power of which is employed for designing a dictionary matrix. A testing signal can be sparsely represented as a linear combination of some columns of the dictionary. The sparse coefficients are estimated by [Formula: see text] norm optimization, and the residuals of sparse coefficients are exploited for classification. The proposed classification algorithm was applied to two BCI datasets and compared with two traditional broadband CSP-based algorithms. The results showed that the proposed algorithm provided superior classification accuracies, which were better than those yielded by traditional algorithms, verifying the efficacy of the present algorithm.
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Ozsoy, M. S., D. Durmus, G. Alayli, G. Sarisoy und A. Bilgici. „THU0488 PSYCHIATRIC SYMPTOMS, TEMPERAMENT PROFILE, STRESS PERCEPTION AND SLEEP QUALITY IN THE PATIENTS WITH CHRONIC SHOULDER PAIN: RELATIONSHIP WITH PAIN, DISABILITY, AND FUNCTIONAL CAPACITY“. Annals of the Rheumatic Diseases 79, Suppl 1 (Juni 2020): 481.2–482. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3817.
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Background:Shoulder pain is very common in general population. Psychiatric symptoms and poor sleep quality related with chronic pain and disability may be present in these patients.Objectives:The aim of this study was to investigate the psychiatric symptoms, perceived stress, temperament profile and sleep disturbance in the patients with chronic shoulder pain (CSP) and also to evaluate the relationship with pain, disability, and functional capacity.Methods:We prospectively evaluated 150 patients (M/F=41/109) (60.46±10.59 years) who have had shoulder pain for at least 3 months and 120 healthy controls (M/F=35/85) (58.35±8.52 years). Pain was evaluated with Visual Analog Scale (VAS), disability with Shoulder Disability Questionnaire (SDQ), functionality with The University of California-Los Angeles (UCLA) Shoulder Scale and range of shoulder motion, temperament profiles with TEMPS-A, stress perception with Perceived stress scale (PSS), psychiatric symptoms with Symptom Checklist-90-R (SCL-90R), Rosenberg self esteem with Self-Esteem Scale (RSES) and sleep disturbance with Pittsburgh sleep quality index (PSQI).Results:The mean VAS pain score, SDQ score, and UCLA score of the patients with shoulder pain were 4.34±1.79, 61.98±26.88, and 58.90±17.78, respectively. SCL-90-R total and all subscale scores except interpersonal sensitivity, psychoticism, paranoid, and phobia were significantly higher in the patient group than the control group (p<0.05). Also PSQI total and sleep quality and latency subscale scores were significantly higher in the patient group (p<0.05). There was no significant difference between the patient and control groups in terms of RSES and PSS. The study identified 28 depressive temperament in the patient group which was statistically different from the control group (p<0.05). There were no significant differences between two groups in terms of cyclothymic, irritable, anxious, and hyperthymic temperaments (p>0.05). When the patient group is evaluated according to functionality, the patients having fair/poor shoulder function had more psychiatric symptoms except hostility, poor sleep quality, decreased self-esteem and increased stress perception. Also, anxious and depressive temperaments were found more common in the patients with fair/poor shoulder function. Psychiatric symptoms (somatization, obsessive-compulsive, interpersonal-sensitivity, depression and anxiety) and total PSQI were positively correlated with SDQ (p<0.05). There was positive correlation between PSS and SDQ (p>0.05).SCL90R total score, subscale of depression and anxiety, total PSQI and PSS were significantly correlated with VAS score (p<0.05).Conclusion:We found psychiatric symptoms such as obsessive-compulsive besides somatization, anxiety, depression, hostility and sleep disturbances higher in the patients with CSP. Additionally, psychiatric symptoms, anxious and depressive temperaments were more common in the patients with fair/poor shoulder function. Self-esteem was not related with the pain. All these findings indicate the importance of psychological health in the patients with CSP. In order to reach treatment goals, psychiatric symptoms and temperament profiles of these patients also should be considered.Disclosure of Interests: :None declared
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Et. al., Khyrinaairinfariza Abu Samah,. „Naïve Bayes Twitter Sentiment Analysis In Visualizing The Reputation Of Communication Service Providers: During Covid-19 Pandemic“. Turkish Journal of Computer and Mathematics Education (TURCOMAT) 12, Nr. 5 (10.04.2021): 1753–64. http://dx.doi.org/10.17762/turcomat.v12i5.2176.
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We present the real-world public sentiment expressed on Twitter using the proposed conceptual model (CM) to visualize the communication service providers (CSP) reputation during the Covid-19 pandemic in Malaysia from March 18 until August 18, 2020. The CM is a guideline that entails public tweets directly or indirectly mentioned to the three biggest CSP in Malaysia: Celcom, Maxis, and Digi. A text classifier model optimized for short snippets like tweets is developed to make bilingual sentiment analysis possible. The two languages explored are Bahasa Malaysia and English since they are the two most spoken languages in Malaysia. The classifier model is trained and tested on a huge multidomain dataset pre-labeled with the labels “0” and “1”, which resemble “positive” and “negative”, respectively. We used the Naïve Bayes (NB) technique as the core of the classifier model. Functionality testing has done to ensure no significant error that will render the application useless, and the accuracy testing score of 89% is considered quite impressive. We came out with the visualization through the word clouds and presented -56%, -42%, and -43% of Net Brand Reputation for Celcom, Maxis, and Digi.
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Yilmaz, Ilker. „Social Performance vs. Financial Performance“. International Journal of Finance & Banking Studies (2147-4486) 2, Nr. 2 (21.04.2013): 53–65. http://dx.doi.org/10.20525/ijfbs.v2i2.146.
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In recent decades, it is gaining more and more dominance in both academic and business life that the company exists for and has responsibilities toward a wider group of stakeholders and it must have some objectives other than profitability. To achieve sustainable development and growth, the companies must assume more duties, which is called the term “corporate social responsibility (CSR).” In the literature, it is questioned whether CSR activities benefit the company or not; whether there is any relationship exists between CSR activities and the company’s financial performance and the direction of the relationship. We aimedto explore that whether there is any effect corporate social performance (CSP) on financial performance and position and vice versa. We performed content analysis through annual reports and derived a social score composed of the items included in disclosure guidelines and some criteria used in CSR ratings. We also used several financial position and financial performance indicators. In order to explore the relationship between CSP and financial indicators, we run panel data regressions. We found significant results for some of the indicators, where some of the indicators gave insignificant results. The reporting of CSR activities is in very low levels. The conscious toward CSR and sustainability must be promoted and the companies must assume more active roles. The reporting of those activities is also important.
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Qiu, Huiying, Brenda M. Sandmaier, Barry E. Storer, Thomas Chauncey, Finn Petersen, Michael A. Pulsipher, Benedetto Bruno et al. „A Prospective Multicenter Study of Nonmyeloablative Conditioning with TBI or Fludarabine/TBI for HLA-Matched Related Hematopoietic Cell Transplantation for Treatment of Hematologic Malignancies with Post Grafting Immunosuppression with Tacrolimus and Mycophenolate Mofetil: 10-Year Experience“. Blood 126, Nr. 23 (03.12.2015): 1949. http://dx.doi.org/10.1182/blood.v126.23.1949.1949.
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Abstract Background: Nonmyeloablative conditioning with 2-Gy TBI alone or in combination with fludarabine (FLU/TBI) and HLA-matched related donor peripheral blood allografts followed by cyclosporine (CSP) and mycophenolate mofetil (MMF) for the prophylaxis of graft-versus-host disease (GVHD) is an effective therapy for many hematologic malignancies with reliable engraftment and moderate toxicity. The major causes of non-relapse mortality (NRM) are the development of acute and chronic GVHD. Several studies have demonstrated that tacrolimus may offer advantages compared with CSP for the prevention of GVHD in patients treated with myeloablative conditioning. The combination of tacrolimus and MMF, which has been used for GVHD prophylaxis after myeloablative hematopoietic cell transplantation (HCT), was well tolerated with low toxicity. Pilot data suggested an improved and perhaps superior GVHD prophylaxis with tacrolimus/MMF compared to our extensive historical experience using CSP/MMF with nonmyeloablative HCT. The purpose of this study is to evaluate the incidence of grade III-IV and II-IV acute GVHD, extensive chronic GVHD, along with the rate of NRM, relapse/progression, and overall survival after nonmyeloablative conditioning and post-grafting immunosuppression with tacrolimus and MMF. Methods: In a phase II multicenter clinical trial we evaluated the effect of post grafting immunosuppression with tacrolimus and MMF for the prophylaxis of GVHD following nonmyeloablative conditioning with 2-Gy TBI alone or in combination with 90mg/m2 FLU (FLU/TBI) for patients with hematologic malignancies. Patients at low risk of graft rejection (preceding autologous HCT within 6 months) received TBI alone (n=50) while the remaining patients received FLU/TBI conditioning (n=100). Tacrolimus was administered orally (0.06 mg/kg, Q12 hr) from days -3 to +56 and in the absence of GVHD tapered off by day +180. Tacrolimus was targeted to 15-20 ng/ml for the first 28 days and 10-20 ng/ml subsequently while on full dose. MMF was given orally (15 mg/kg, Q12 hr) from day 0 until day 27. Results: 150 patients were enrolled from 2004 to 2013 and received peripheral blood stem cells (median doses of 8.1×106 CD34+ cells/kg and 3.5×108 CD3+ cells/kg) from HLA-matched related donors. Diagnosis at transplant included AML (n=42), ALL (n=6), CLL (n=2), MDS/MPD (n=12), NHL (n=25), HL (n=8), and MM (n=55). Median patient age was 56 (range 19-74) years. Sixty-one percent of patients had an HCT comorbidity index (HCT-CI) score of greater than 2. Five percent of patients had failed a prior autologous HCT in FLU/TBI group. Median follow-up was 5.2 years. One graft failure was observed in the FLU/TBI group and no patients rejected their graft. The early NRM at day 100 was 1%. The cumulative incidences of grade II-IV and grade III-IV acute GVHD at 120 days were 26% (FLU/TBI 25%; TBI 28%) and 4% (FLU/TBI 2%; TBI 8%), respectively. Only one patient developed grade IV acute GVHD. Forty-eight percent of patients had chronic GVHD by 5 years (FLU/TBI 44%; TBI 54%). Five-year NRM was low at 12%. The overall cumulative incidence of relapse/progression at 5 years was 52%. Five-year overall and progression-free survivals were 51% and 37%, respectively. Conclusions: Post-grafting immunosuppression and GVHD prophylaxis with tacrolimus/MMF resulted in a low risk of acute and chronic GVHD, which compares favorably with our experience in a concurrent trial using CSP/MMF with FLU/TBI conditioning (46% grades II-IV acute and 72% chronic GVHD with CSP/MMF, respectively; BBMT, 2013, 19: 1340-1347). Furthermore, we recently reported that the active metabolite of MMF (MPA) concentration at steady state (MPA Css) was lower in patients who received concomitant CSP than patients receiving tacrolimus. Low total MPA Css was associated with an increased risk of severe acute GVHD following nonmyeloablative HCT (BBMT 2013, 19: 1159-1166). Together these data warrant consideration of a randomized phase III trial to investigate the role of tacrolimus/MMF versus CSP/MMF in nonmyeloablative HCT. Figure 1. Cumulative incidences of grade II to IV acute GVHD (A) and chronic GVHD (B) Figure 1. Cumulative incidences of grade II to IV acute GVHD (A) and chronic GVHD (B) Disclosures Maloney: Seattle Genetics: Honoraria; Juno Therapeutics: Research Funding; Janssen Scientific Affairs: Honoraria; Roche/Genentech: Honoraria.
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Ritz, Kathryn E., Bradley J. Heins, Roger D. Moon, Craig C. Sheaffer und Sharon L. Weyers. „Milk Production, Body Weight, Body Condition Score, Activity, and Rumination of Organic Dairy Cattle Grazing Two Different Pasture Systems Incorporating Cool- and Warm-Season Forages“. Animals 11, Nr. 2 (21.01.2021): 264. http://dx.doi.org/10.3390/ani11020264.
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Organic dairy cows were used to evaluate the effect of two organic pasture production systems (temperate grass species and warm-season annual grasses and cool-season annuals compared with temperate grasses only) across two grazing seasons (May to October of 2014 and 2015) on milk production, milk components (fat, protein, milk urea nitrogen (MUN), somatic cell score (SCS)), body weight, body condition score (BCS), and activity and rumination (min/day). Cows were assigned to two pasture systems across the grazing season at an organic research dairy in Morris, Minnesota. Pasture System 1 was cool-season perennials (CSP) and Pasture System 2 was a combination of System 1 and warm-season grasses and cool-season annuals. System 1 and System 2 cows had similar milk production (14.7 and 14.8 kg d−1), fat percentage (3.92% vs. 3.80%), protein percentage (3.21% vs. 3.17%), MUN (12.5 and 11.5 mg dL−1), and SCS (4.05 and 4.07), respectively. Cows in System 1 had greater daily rumination (530 min/day) compared to cows in System 2 (470 min/day). In summary, warm-season annual grasses may be incorporated into grazing systems for pastured dairy cattle.
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Salvi, Antonio, Emanuele Doronzo, Anastasia Giakoumelou und Felice Petruzzella. „CSR and Corporate Financial Performance: An Inter-Sectorial Analysis“. International Journal of Business and Management 14, Nr. 11 (19.10.2019): 193. http://dx.doi.org/10.5539/ijbm.v14n11p193.
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This study examines the relationship between corporate social responsibility (CSR) and corporate financial performance (CFP), shedding new light on the lack of academic consensus and prevailing failure to deal with endogeneity in data. To this purpose, the authors recalculate ESG performance starting from the four pillars (economic, environmental, governance and social) provided by Thomson Reuters’ Asset4 database, able to determine a firm’s CSP. We adjust each ESG pillar score accounting for the firm’s sector, size and headquarter geographic area. We empirically test the relationship with a Generalized Method of Moments approach (GMM) in order to tackle the widely disputed endogeneity issues arising in this type of datasets.
Results highlight a positive relationship between CSR, as measured in a tailored manner in this study, and corporate financial performance.
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Quesada, P., und V. Compère. „Adjonction de séances de stimulation magnétique transcrânienne répétée (rTMS) à visée potentialisatrice de l’électroconvulsivothérapie (ECT) dans la dépression résistante : à propos de 2 cas“. European Psychiatry 30, S2 (November 2015): S159. http://dx.doi.org/10.1016/j.eurpsy.2015.09.321.
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L’épisode dépressif majeur (EDM) : problème de santé publique majeur avec presque 121 millions de personnes affectées dans le monde et une prévalence vie entière de 5 à 15 % . Son évolution (20 % de chronicisation et 30 % de résistance aux antidépresseurs) ainsi que ses complications (suicide, dénutrition ou déshydratation) demeurent des enjeux majeurs pour les soignants. L’électroconvulsivothérapie (ECT) : un des traitements les plus efficaces de l’EDM, indiquée en cas de résistance médicamenteuse mais cette réponse est partielle avec 48 % de rémission chez les patients présentant une dépression résistante . La stimulation magnétique transcrânienne répétée haute fréquence (HF-rTMS) : thérapeutique instrumentale non invasive ayant prouvée son efficacité dans l’EDM . Les ECT et l’HF-rTMS du cortex préfrontal dorsolatéral gauche (DLPFC) auraient un mode d’action commun. Nous nous sommes intéressés à la possibilité d’utiliser la rTMS afin de potentialiser les ECT.Méthodes de stimulationLa rTMS du DLPFC gauche a été réalisée à haute fréquence (20 Hz, 90 % du seuil moteur, 20 trains de 2 secondes avec des intertrains de 60 secondes), de manière quotidienne, selon une méthode de repérage visuelle. Les ECT ont été réalisés de manière bitemporale. Une titration a été réalisée afin de définir individuellement le seuil épileptogène de chaque patient.Description des casMéthode de repérage visuel « 10–20 ». Le patient 1 était une femme de 27 ans atteinte d’un trouble bipolaire de type 1 diagnostiqué à l’âge de 22 ans. Elle présentait un EDM évoluant depuis 9 mois. Elle était traitée par aripiprazole et lithium, après avoir reçu plusieurs thymorégulateurs et antidépresseurs. Les symptômes étaient un ralentissement psychomoteur majeur, une thymie triste avec pleurs, de l’anxiété et des idées suicidaires. Elle bénéficia de 10 séances de HF-rTMS du DLPFC gauche suivis d’ECT bitemporale. Les idéations suicidaires disparurent et la thymie s’améliora nettement après la troisième séance d’ECT. Initialement à 25 le score de Hamilton diminua à 2 après 5 ECT puis à 0 après 10 ECT. Le patient 2 était une femme de 39 ans souffrant d’une dépression chronique résistante, avec des antécédents de tentatives d’autolyses graves. Son traitement était composé de sertraline, lithium et loxapine. À son admission, elle présentait un ralentissement psychomoteur, une anhédonie, une anxiété, des troubles du sommeil ainsi que des idées suicidaires. Elle reçut 7 séances de HF-rTMS avant les ECT. La patiente fut sortante de l’hôpital après la sixième séance d’ECT. Initialement à 19 le score de Hamilton diminua à 3 après 5 ECT puis à 2 après 10 ECT. Pour les deux patientes, les crises électriques furent plus longues, avec des intensités de stimulation moindre et les améliorations cliniques plus rapides comparés aux autres patients présentant un état clinique et un traitement par ECT similaires, sans effet secondaire notable. Caractéristiques des crises électriques.DiscussionLa neuro-excitabilité corticale a été étudiée chez des patients présentant un EDM. Plusieurs études ont retrouvé une diminution de l’ICI (inhibition intracorticale) et du CSP (période de silence corticale) au décours de l’EDM, impliquant un rôle probable du système GABAergique dans son ensemble. De plus, la normalisation du taux de GABA préfrontal est associée à la rémission dans l’EDM. L’ensemble de ces résultats est en faveur d’une diminution de la transmission synaptique GABAergique dans la dépression. Des auteurs ont retrouvé une augmentation du taux de GABA cérébral ainsi que de l’activité GABA-B après un traitement par ECT chez l’homme. La rTMS augmente également le CSP et les patients déprimés répondant à l’HF-rTMS du DLPFC gauche (20 Hz) ont un CSP et une ICI augmentées. Les modifications de l’ICI sont corrélées avec l’amélioration du score de HAMD (Hamilton Rating Scale for Depression). Les travaux d’Otis et Mody indiquent que les changements du CSP ne sont détectables qu’après une importante activation des interneurones inhibiteurs, suggérant que l’activation des récepteurs GABAb nécessite une exposition prolongée au GABA ou une forte concentration de GABA. La HF-rTMS du DLPFC gauche et les ECT sembleraient donc avoir une activité GABAergique corticale commune avec une majoration du taux cérébral de GABA et des modifications de neuro-excitabilité. On peut s’attendre que la HF-rTMS du DLPFC gauche expose de manière répétée les récepteurs GABA à leur substrat et aurait un rôle d’amorce avant la réalisation d’ECT, permettant une meilleure efficacité du traitement par ECT comme dans le cas de nos deux patients.
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Li, Ting, Jinhua Zhang, Tao Xue und Baozeng Wang. „Development of a Novel Motor Imagery Control Technique and Application in a Gaming Environment“. Computational Intelligence and Neuroscience 2017 (2017): 1–16. http://dx.doi.org/10.1155/2017/5863512.
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We present a methodology for a hybrid brain-computer interface (BCI) system, with the recognition of motor imagery (MI) based on EEG and blink EOG signals. We tested the BCI system in a 3D Tetris and an analogous 2D game playing environment. To enhance player’s BCI control ability, the study focused on feature extraction from EEG and control strategy supporting Game-BCI system operation. We compared the numerical differences between spatial features extracted with common spatial pattern (CSP) and the proposed multifeature extraction. To demonstrate the effectiveness of 3D game environment at enhancing player’s event-related desynchronization (ERD) and event-related synchronization (ERS) production ability, we set the 2D Screen Game as the comparison experiment. According to a series of statistical results, the group performing MI in the 3D Tetris environment showed more significant improvements in generating MI-associated ERD/ERS. Analysis results of game-score indicated that the players’ scores presented an obvious uptrend in 3D Tetris environment but did not show an obvious downward trend in 2D Screen Game. It suggested that the immersive and rich-control environment for MI would improve the associated mental imagery and enhance MI-based BCI skills.
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Baxi, Heta D., und Megha S. Sheth. „Professionalism as a core value of postgraduate physiotherapy students of Ahmedabad: a cross sectional survey“. International Journal Of Community Medicine And Public Health 7, Nr. 12 (25.11.2020): 4885. http://dx.doi.org/10.18203/2394-6040.ijcmph20205157.
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Background: Professionalism is defined by the Chartered Society Of Physiotherapy (CSP) as “the qualities, skills, competence and behaviors expected of individuals belonging to any given profession including physiotherapy.” The number of physiotherapy students in India is increasing. Moreover, with the advent of modern technology and commercialism, there is a rising threat to the therapist-patient relationship as well as compromise in the ethical commitment to the field due to stiff competition in the market. Hence, it is essential that the standard of practice should be maintained and should be improvised. The purpose of this study is to find the perceived level of professionalism of post graduate physiotherapy students. Methods: The cross-sectional survey was done via APTA’S ‘Professionalism In Physical Therapy: Core Values. There are 7 core values with 69 indicators; total score is 345. It has been validated and used previously in India. 100 students were included; 67, 1st year & 33, 2nd year post graduate physiotherapy students of Ahmedabad through convenience sampling. Analysis was done in Microsoft excel 2013. Results: The mean scores for the core values were as follows: Accountability:40.53±6.37/50; Altruism: 17.98+3.78/25; Compassion/Caring: 43.65±6.62/55; Excellence: 44.01±6.73/55; Integrity: 43.69±6.16/60; Professional Duty: 28.67±4.70/35; Social responsibility: 45.84±7.64/60.Conclusions: Physiotherapy PG students had overall high scores in the core values. Further research is required to understand the current scenario so that appropriate changes can be made in the curriculum and strategies can be formulated for high quality patient care.
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Ionova, Tatyana, Tatyana Nikitina, Elza Lomaia, Alexandr Myasnikov, Tatyana Pospelova, Andrey Evseev, Taras Gritsenko et al. „Patient-Reported Outcomes in Myelofibrosis Patients Help to Identify Patients' Needs“. Blood 126, Nr. 23 (03.12.2015): 5198. http://dx.doi.org/10.1182/blood.v126.23.5198.5198.
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Abstract Myelofibrosis (MF) is the most symptomatic of the myeloproliferative neoplasms and is associated with the greatest symptom burden and poorest prognosis. Patient-reported outcomes is an effective way to identify patients' needs and risks/benefits of MF treatment. We aimed to study quality of life (QoL) and symptom burden in MF patients in a real-world setting. 44 MF patients - 27 primary MF, 8 post-essential thrombocytopenia, 9 post-polycythemia vera - were enrolled in the multicenter real-world QoL study. Mean age - 60.8±13.3; male/female - 14/30. All the patients received the best available treatment (BAT, n=28) or novel treatment modality ruxolitinib (n=16) for at least 6 months (range 6-160 mths). A high proportion of patients (80%) had intermediate to high prognostic risk scores according to International Prognostic Scoring System. All the patients completed the QoL questionnaire SF-36, symptom assessment questionnaire CSP-MF and Patient Global Impression of Change (PGIC) tool. Integral QoL Index (IQoLI) in MF patients was calculated on the basis of SF-36 and QoL impairment grade was assessed in comparing with QoL population norms (PN). Comparison t-test for independent samples or Mann-Whitney test was applied. The heterogeneity of MF patients population in terms of QoL impairment was shown: 55% of patients had mild QoL impairment (IQoLI≤25% from PN), 7% - moderate (IQoLI≤25-50% from PN), 38% - severe or critical QoL impairment (IQoLI≤50% from PN). Patients receiving BAT exhibited more pronounced QoL impairment as compared to patients receiving ruxolitinib (p<0.05); they had worse physical functioning, general health, vitality, social functioning, and mental health (p<0.05). All the patients experienced multiple symptoms; the most severe symptoms were fatigue, inactivity and pain in bones/muscles. The symptoms were more expressed in patients on BAT as compared to patients on ruxolitinib (p<0.005). Patient's impression of health changes was better in patients treated with ruxolitinib: the mean PGIC score was higher in patients on BAT on ruxolitinib - 4.4 vs 2.3 (p=0.001). Quality of life and perceived change in health condition are better and symptom severity is less in MF patients on ruxolitinib therapy than those on BAT. Results of this real-world study demonstrate benefits of ruxolitinib therapy from patient perspective. Patient-reported outcomes are of help to better identify the needs of MF patients. Disclosures No relevant conflicts of interest to declare.
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Baron, Frederic, R. Storb, B. Storer, D. Maloney, M. Maris, D. Niederwieser, J. Shizuru et al. „Allogeneic Hematopoietic Cell Transplantation (HCT) with Nonmyeloablative Conditioning after Failed Myeloablative HCT: Factors Affecting Outcomes.“ Blood 106, Nr. 11 (16.11.2005): 1143. http://dx.doi.org/10.1182/blood.v106.11.1143.1143.
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Abstract We describe data from 147 consecutive patients (median age, 46; range, 9–73 yrs) who had failed myeloablative conventional autologous (n=135), allogeneic (n=10), or syngeneic (n = 2) HCT, and were given HLA-matched related (MRD) (n=62) or unrelated (URD) (n=85) HCT after conditioning with 2 Gy TBI with or without 90 mg/m2 of fludarabine with the aim of identifying predictive factors for HCT outcomes. Postgrafting immunosuppression consisted of cyclosporine (CSP) and mycophenolate mofetil (MMF). Median times between failed HCT and nonmyeloablative HCT were 22 (range, 3–128) months for MRD recipients and 25 (range, 4–222) months for URD recipients, respectively. Median follow-up for surviving patients was 27 (range, 7–66) months. Comorbidities at HCT were scored according to the HCT-specific comorbidity index (HCT-CI, Sorror et al. Blood 2005). Sustained engraftment was achieved in 141 patients, while 6 (5 URD and 1 MRD) rejected their grafts 13 to 1123 days after HCT. Median donor T-cell chimerism levels on days 28, 56, 84, 180 and 365 after HCT were 95%, 97%, 97%, 99% and 100%, respectively. Grades II, III and IV acute GVHD were seen in 36%, 15%, and 5% of MRD recipients, and 48%, 8%, and 7% of URD recipients, respectively. Extensive chronic GVHD occurred in 47% of MRD recipients and 57% of URD recipients. Three-yr probabilities of nonrelapse mortality (NRM), relapse, progression-free survival (PFS) and overall survival (OS) were 31%, 48%, 22% and 32% in MRD recipients and 34%, 37%, 29% and 42% in URD recipients, respectively. The best outcomes were observed in patients with non-Hodgkin lymphoma (NHL), while patients with multiple myeloma and Hodgkin disease had poor outcomes due to high incidences of relapse/progression (Table 1). Pre-transplant factors associated with better PFS in multivariate analyses were chemosensitive malignancy (CR/PR) (P=0.0009), absence of comorbidity (HCT-CI score 0) (P=0.02), and URD (P=0.03). Pre-transplant factors associated with better OS in multivariate analyses were chemosensitive malignancy (CR/PR) at HCT (P=0.02), and absence of comorbidity (HCT-CI score 0) at HCT (P=0.008). In time-dependent analyses, grade II-IV acute GVHD was associated with increased NRM (HR=2.56, P=0.008), and a trend for increased risk of overall mortality (HR 1.53, P=0.07), while chronic GVHD was associated with a lower risk of relapse (HR 0.47, P=0.05) and no increase in overall mortality (HR 0.84, P=0.53). In conclusion, encouraging outcomes could be achieved with nonmyeloablative conditioning in selected patients having failed high-dose HCT, particularly in patients with NHL. Results with URD were as least as good than those with MRD, suggesting that this approach should not be restricted to patients with a MRD. Table 1: Survival according to diagnosis OS @ 3 yrs PFS @ 3 yrs NHL-MCL (n=14) 64% 57% NHL-Indolent (n=12) 56% 56% NHL-Aggressive (n=24) 40% 36% Hodgkin Disease (n=35) 33% 9% CML/AML/MDS (n=35) 31% 27% Multiple myleoma (n=22) 26% 0% Other (n=5) 27% 30%
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Zhang, Shiyu, Rodrigo Maegawa, Savita Nandal und Pallavi Patwardhan. „Targeted Literature Review of Patient Reported Outcomes (PROs) in Chronic Myeloid Leukemia (CML) Patients Receiving Second and Later Lines of Treatment“. Blood 136, Supplement 1 (05.11.2020): 26–27. http://dx.doi.org/10.1182/blood-2020-140402.
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Background: Tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of chronic CML in the last several years; however, the failure rates associated with TKIs still remain high in second line (50%) and later lines (75%-80%) treatment. Also, patients often experience adverse events associated with these TKIs, but are often left with no alternative treatment in real world practice which might result in TKI cycling. There is a need to understand the quality of life (QoL) and symptom burden among these patients, in order to better manage their disease and also to explore new treatments. The objectives of this study were to summarize the PROs among patients with CML receiving 2nd/3rd/4th line (2L/3L/4L) treatment, and the instruments used for QoL and symptom burden assessment in clinical trials and real world studies. Methods: Embase, MEDLINE, and the Cochrane Library were searched using pre-defined search terms to identify studies published from 1/1/2010 to 6/15/2020. Following the title/abstract and full-text screening based on the inclusion/exclusion criteria (see Table), one reviewer independently extracted all relevant data with random quality check (~20% of the sample) by a 2nd reviewer. Included studies reported QoL, symptom burden, or any PROs of adult CML patients who received 2L/3L/4L treatment. Only clinical trials and observational studies published in English were included, including conference abstracts. Results: Database search identified 1,377 records, which were screened to identify 20 studies (5 observational studies and 15 clinical trial-based studies) that met eligibility criteria (see Figure). Of the included studies, 16 targeted chronic phase CML patients only. More than half of the studies (n=14) focused on patients receiving 2L treatment (bosutinib, dasatinib, or nilotinib) only, and six reported QoL data on patients receiving 2L/3L/4L treatment, out of which four studies reported results by line of therapy. Out of 15 studies reporting a follow-up period, 13 observed patients ≥ 12 months with a maximum of 24 months. The duration between observations were usually 12 weeks for observational studies; while shorter duration was observed in clinical trials. Six clinical trial-based studies were associated with one trial (NCT00261846). Instruments used to assess QoL included four generic instruments [Functional Assessment of Cancer Therapy - General (FACT-G), EuroQol 5 dimension (EQ-5D), 36-Item Short Form Survey (SF-36), European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30)], three disease specific instruments [Functional Assessment of Cancer Therapy - Leukemia (FACT-Leu), MD Anderson Symptom Inventory chronic myeloid leukemia (MDASI-CML), Comprehensive Symptom Profile in Chronic Myeloid Leukemia Patients (CSP Leuk-CML)], one Work Productivity and Activity Impairment (WPAI) questionnaire, and two additional general questions on QoL. Ten studies applied both generic and disease specific instruments altogether to evaluate patients' QoL and symptom burden. For 2L TKI treatment, studies have shown improvement in QoL following treatment; however, one study indicated that although patients were content with their QoL, they reported poor symptom scores on mobility, usual activities, and pain/discomfort. Among four studies examining PROs by line of therapy, only one study reported results on the 4L cohort individually, which showed lowest baseline FACT-G and FACT-Leu score in the 4L cohort compared to other cohorts, especially in terms of the physical and emotional well-being domain. Discrepancies existed in QoL between 2L- and 3L cohorts. Two studies found QoL to be similar between the 2L- and 3L cohorts, while the other two observed the QoL was lower in the 3L cohorts. In addition, three reported that QoL scores remained stable throughout observation period regardless of the line of therapy, but one study demonstrated the utility score got improved in the 2L but not the 3L cohort. Conclusions: Evidence on PROs in CML patients receiving 3L/4L treatment is very limited, especially real-world data. Existing research indicates patients with CML receiving later lines of treatment may have poor quality of life. Robust real-world studies with longer follow-up period are needed to provide evidence on later lines treatment management among CML patients. Disclosures Zhang: Novartis Pharmaceutical Corporation: Current Employment. Maegawa:Novartis Pharmaceutical Corporation: Current Employment, Current equity holder in publicly-traded company. Patwardhan:Novartis Pharmaceutical Corporation: Current Employment, Current equity holder in publicly-traded company.
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Le Terrier, Christophe, Marco Vinetti, Paul Bonjean, Régine Richard, Bruno Jarrige, Bertrand Pons, Benjamin Madeux et al. „Impact of a restrictive antibiotic policy on the acquisition of extended-spectrum beta-lactamase-producing Enterobacteriaceae in an endemic region: a before-and-after, propensity-matched cohort study in a Caribbean intensive care unit“. Critical Care 25, Nr. 1 (26.07.2021). http://dx.doi.org/10.1186/s13054-021-03660-z.
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Abstract Background High-level antibiotic consumption plays a critical role in the selection and spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) in the ICU. Implementation of a stewardship program including a restrictive antibiotic policy was evaluated with respect to ESBL-E acquisition (carriage and infection). Methods We implemented a 2-year, before-and-after intervention study including all consecutive adult patients admitted for > 48 h in the medical-surgical 26-bed ICU of Guadeloupe University Hospital (French West Indies). A conventional strategy period (CSP) including a broad-spectrum antibiotic as initial empirical treatment, followed by de-escalation (period before), was compared to a restrictive strategy period (RSP) limiting broad-spectrum antibiotics and shortening their duration. Antibiotic therapy was delayed and initiated only after microbiological identification, except for septic shock, severe acute respiratory distress syndrome and meningitis (period after). A multivariate Cox proportional hazard regression model adjusted on propensity score values was performed. The main outcome was the median time of being ESBL-E-free in the ICU. Secondary outcome included all-cause ICU mortality. Results The study included 1541 patients: 738 in the CSP and 803 in the RSP. During the RSP, less patients were treated with antibiotics (46.8% vs. 57.9%; p < 0.01), treatment duration was shorter (5 vs. 6 days; p < 0.01), and administration of antibiotics targeting anaerobic pathogens significantly decreased (65.3% vs. 33.5%; p < 0.01) compared to the CSP. The incidence of ICU-acquired ESBL-E was lower (12.1% vs. 19%; p < 0.01) during the RSP. The median time of being ESBL-E-free was 22 days (95% CI 16-NA) in the RSP and 18 days (95% CI 16–21) in the CSP. After propensity score weighting and adjusted analysis, the median time of being ESBL-E-free was independently associated with the RSP (hazard ratio, 0.746 [95% CI 0.575–0.968]; p = 0.02, and hazard ratio 0.751 [95% CI 0.578–0.977]; p = 0.03, respectively). All-cause ICU mortality was lower in the RSP than in the CSP (22.5% vs. 28.6%; p < 0.01). Conclusions Implementation of a program including a restrictive antibiotic strategy is feasible and is associated with less ESBL-E acquisition in the ICU without any worsening of patient outcome.
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Acharyya, Moumita, und Tanuja Agarwala. „Relationship between CSR motivations and corporate social performance: a study in the power industry in India“. Employee Relations: The International Journal ahead-of-print, ahead-of-print (30.06.2020). http://dx.doi.org/10.1108/er-01-2019-0091.
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PurposeThe paper aims to understand the different motivations / reasons for engaging in CSR initiatives by the organizations. In addition, the study also examines the relationship between CSR motivations and corporate social performance (CSP).Design/methodology/approachThe data were collected from two power sector organizations: one was a private sector firm and the other was a public sector firm. A comparative analysis of the variables with respect to private and public sector organizations was conducted. A questionnaire survey was administered among 370 employees working in the power sector, with 199 executives from public sector and 171 from private sector.Findings“Philanthropic” motivation emerged as the most dominant CSR motivation among both the public and private sector firms. The private sector firm was found to be significantly higher with respect to “philanthropic”, “enlightened self-interest” and “normative” CSR motivations when compared with the public sector firms. Findings suggest that public and private sector firms differed significantly on four CSR motivations, namely, “philanthropic”, “enlightened self-interest”, “normative” and “coercive”. The CSP score was significantly different among the two power sector firms of public and private sectors. The private sector firm had a higher CSP level than the public sector undertaking.Research limitations/implicationsFurther studies in the domain need to address differences in CSR motivations and CSP across other sectors to understand the role of industry characteristics in influencing social development targets of organizations. Research also needs to focus on demonstrating the relationship between CSP and financial performance of the firms. Further, the HR outcomes of CSR initiatives and measurement of CSP indicators, such as attracting and retaining talent, employee commitment and organizational climate factors, need to be assessed.Originality/valueThe social issues are now directly linked with the business model to ensure consistency and community development. The results reveal a need for “enlightened self-interest” which is the second dominant CSR motivation among the organizations. The study makes a novel contribution by determining that competitive and coercive motivations are not functional as part of organizational CSR strategy. CSR can never be forced as the very idea is to do social good. Eventually, the CSR approach demands a commitment from within. The organizations need to emphasize more voluntary engagement of employees and go beyond statutory requirements for realizing the true CSR benefits.
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Rotter, Gabriele, Sylvia Binting, Tatjana Tissen-Diabaté, Miriam Ortiz und Benno Brinkhaus. „Osteopathic Medicine in Four Chronic Musculoskeletal Pain Diseases: An Observational Trial with Follow-Up“. Complementary Medicine Research, 19.08.2021, 1–14. http://dx.doi.org/10.1159/000518311.
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<b><i>Background and Aim:</i></b> Patients with chronic musculoskeletal pain diseases (CMPDs) often use osteopathic medicine (OM), although the changes in patients with pain diseases are still insufficiently investigated. This study aimed to observe changes along and after OM in addition to routine care on pain, functioning, and quality of life in patients with four CMPDs. <b><i>Methods:</i></b> In this observational trial with follow-up, patients suffering from chronic neck pain (CNP, <i>n</i> = 10), chronic low back pain (CLBP, <i>n</i> = 10), chronic shoulder pain (CSP, <i>n</i> = 10), or chronic knee pain (CKP, <i>n</i> = 10) received up to six OM sessions in addition to routine care. <b><i>Results:</i></b> A total of 40 patients (73% female, mean age 47.7 ± 8.3 years, mean pain intensity 59.4 ± 12.5 mm, measured by a visual analog scale [VAS] 0–100 mm) were included. After 26 weeks, there was an improvement in the VAS pain score in the whole population (mean difference to baseline –33.1 mm [95% CI –40.5 to –25.7]), as well in the patients with the four diseases: CNP (–33.7 mm [–54.7 to –12.6]), CLBP (–28.2 mm [–47.9 to –8.4]), CSP (–32.4 [–46.8 to –18.0]), and CKP (–38.1 mm [–49.1 to –27.0]). Regarding disease-specific outcomes, we found improvements in CNP, as measured by the neck disability index (scale 0–50; mean difference –3.6 [–9.0 to 1.9]), CLBP, as measured by the low back pain rating scale (scale 0–60; –3.4 [–12.5 to 5.7]), CSP, as measured by the disabilities of the arm, shoulder and hand score (scale 0–100; –13.4 [–23.1 to –3.7]), and CKP, as measured by the Western Ontario and McMaster Universities Osteoarthritis Index (scale 0–96; –13.0 [–23.5 to –2.5]). These improvements persisted through week 52. No adverse events were observed. <b><i>Conclusion:</i></b> The study observed beneficial changes along and after the OM treatment in addition to routine care in patients with four different CMPDs. High-quality, multicenter randomized controlled trials are strongly needed to compare the effectiveness of OM and standard care interventions in treating CMPDs in the future. We have provided sufficient data for sample size calculations for these trials.