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Zeitschriftenartikel zum Thema "Cqb"

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Effting, Cristiane, Fernando Gomes Ferreira Oliveira, Iram Moreira Mundim, Alessandro de Carvalho Cruz, Andryne Rego Rodrigues, Caroline Rego Rodrigues, Jerônimo Raimundo de Oliveira-Neto, Marianna Medeiros Barros da Cunha, Adriano de Moraes Arantes und Luiz Carlos da Cunha. „Otimização de método analítico em HPLC-PDA para monitoração terapêutica do bussulfano oral em pacientes transplantados de células-tronco hematopoiéticas“. Research, Society and Development 10, Nr. 6 (07.06.2021): e48110615864. http://dx.doi.org/10.33448/rsd-v10i6.15864.

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Otimizou-se método para monitoração plasmática de bussulfano em pacientes submetidos a transplante de células-tronco hematopoiéticas (TCTH). Utilizou-se HPLC-PDA Shimadzu, coluna C18 (150 mm x 4 mm), metanol/água/acetonitrila (65:20:15, v/v/v), fluxo 1 mL min-1; UV λ = 276 nm, tempo de análise de 17 min; derivatização com dietilcarbamato de sódio, extração com acetato de etila; curva de calibração linear de 200-5000 ng mL-1. A recuperação relativa dos controles foi de 89%±0,04 (CQA = 86%; CQM = 87%; CQB = 93%) e a do PI (padrão interno) foi de 74%±0,47. A recuperação absoluta dos controles foi de 114%±0,03 (CQA = 111%; CQM = 118%; CQB = 113%), e a do PI foi de 102%±2,5. Os limites inferiores de quantificação e detecção obtidos foram, respectivamente, de 200 ng mL-1 e 40 ng mL-1. A linearidade foi analisada pela curva de calibração (200–5000 ng.mL-1) (r = 0,998). A repetibilidade (intracorrida) foi de 1,25%-11,25%, e a precisão intermediária (intercorrida), 2,17%-10,71%. A exatidão encontrada foi de 89,61%-102,18%. A estabilidade de curta duração de amostras extraídas e das soluções foi de 6,25% e 3,18% para CQB, 7,54% e 2,4% para CQA e 13,17% e 4,13% para PI, respectivamente. A estabilidade de ciclos de congelamento e descongelamento de amostras extraídas e das soluções foi de 3,64% e 2,53% para CQB, 9,09% e 5,65% para CQA e 10,32% e 4,82% para PI, respectivamente. Desta forma, foi possível validar uma técnica para determinação do bussulfano em plasma por HPLC-PDA, adequada à monitorização terapêutica de pacientes.
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Elf, Marie, Maria Svedbo Engström und Helle Wijk. „Development of the Content and Quality in Briefs Instrument (CQB-I)“. HERD: Health Environments Research & Design Journal 5, Nr. 3 (April 2012): 74–88. http://dx.doi.org/10.1177/193758671200500308.

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Objective: The Content and Quality in Briefs Instrument (CQB-I) was designed to develop a valid and reliable audit instrument to examine the content and quality of information in documents (briefs) created in the early stages of designing healthcare environments. Background: The importance of effective briefing has been emphasized in many research studies during the past two decades. However, there is no developed instrument for auditing the content and quality of these documents. Methods: The study had a methodological and developmental design based on an established methodology for instrument development and validation. The development process consisted of three main phases: (1) item generation and scale construction; (2) assessment of face and content validity, and (3) testing of the reliability. To obtain face and content validity, expert panels reviewed the CQB-I. Content validity was assessed using the Content Validity Index (I – CVI = item level, S – CVI = scale level). Reliability was tested by test-retest and inter-rater reliability. Results: CQB-I was found to have good content validity (I − CVI = 0.78–1.0 and S – CVI = 0.98). Inter-rater reliability was acceptable (Spearman's correlation = 0.62) and stability was considered high for both raters (83% and 88%, respectively).
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Markel, Russell W., und Jonathan B. Shurin. „Contrasting effects of coastal upwelling on growth and recruitment of nearshore Pacific rockfishes (genus Sebastes)“. Canadian Journal of Fisheries and Aquatic Sciences 77, Nr. 6 (Juni 2020): 950–62. http://dx.doi.org/10.1139/cjfas-2019-0179.

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Knowledge of processes underlying recruitment is critical for understanding marine population dynamics and their response to ocean climate. We investigated the relationship between coastal upwelling and early life history of black rockfish (Sebastes melanops), a midwater aggregating species, and CQB rockfishes (a solitary benthic species complex including Sebastes caurinus, Sebastes maliger, and Sebastes auriculatus), between two oceanographically distinct years on the west coast of Vancouver Island, Canada. We analysed otolith microstructure to determine parturition and settlement dates, pelagic durations, and pre- and postsettlement growth rates. High CQB rockfish recruitment in 2005 was associated with prolonged downwelling and warm ocean temperatures, late parturition dates, fast presettlement growth, short pelagic durations, and small size-at-settlement. In contrast, high black rockfish recruitment in 2006 was associated with strong upwelling and cool ocean temperatures, slow presettlement growth, and protracted pelagic durations. Presettlement growth of both rockfish complexes increased with high sea surface temperature, but was unrelated to chlorophyll a concentration. Our results indicate that the same oceanographic conditions give rise to fast presettlement growth and short pelagic durations for both groups, but that different factors lead to strong recruitment in each.
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Baldwin, Michael. „Christopher Butterfield - CHRISTOPHER BUTTERFIELD: Trip. Quatuor Bozzini. Collection QB. CQB 1719.“ Tempo 72, Nr. 285 (19.06.2018): 96–98. http://dx.doi.org/10.1017/s0040298218000207.

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Watanabe, Jota, und Juan C. Scornik. „Measuring Human Complement Activation by HLA Antibodies“. Archives of Pathology & Laboratory Medicine 130, Nr. 3 (01.03.2006): 368–73. http://dx.doi.org/10.5858/2006-130-368-mhcabh.

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Abstract Context.—The clinical significance of HLA antibodies in transplantation depends on their ability to activate complement, which is measured by the standard complement-dependent cytotoxicity test. Recent reports indicate that C3b measurement on target cells may be a better indicator of human complement activation than standard cytotoxicity. Objective.—To determine the characteristics of the test, the role of other complement components, and the potential influence of the patient's own complement activity. Design.—The T-cell deposition of multiple complement components triggered by HLA alloantibodies was evaluated by flow cytometry using normal human serum as the source of complement. Complement activity in patients' sera was measured after activation with a standard antibody. Results.—When HLA antibodies activate complement, C3b deposition is usually highest, followed by that of C4b and C5b. Deposition of C1q, C3d, iC3b, or C5b-9 was low or undetectable in this study. The C5 was activated only when relatively high levels of C3b were present. There was a critical concentration of antibody, unique for each patient, below which activation of C3 declined abruptly. The complement activity in the serum of candidates for liver, heart, and lung transplantation that was tested with a standard antibody was similar to normal serum. In contrast, kidney transplant candidates exhibited higher complement activity. Unexpectedly, serum C3 activity was retained for at least 72 hours after collection. Conclusions.—Measurement of C3b, and in some instances C4b or C5b, offers a better definition of the ability of HLA antibodies to activate human complement than tests that are in current use. The results provide a necessary baseline to conduct clinical correlation studies.
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Zhang, Lin, Lei Tong, Pengguang Zhu, Peng Huang, Zhengyu Tan, Fangling Qin, Wen Shi et al. „Adsorption of chlortetracycline onto biochar derived from corn cob and sugarcane bagasse“. Water Science and Technology 78, Nr. 6 (19.09.2018): 1336–47. http://dx.doi.org/10.2166/wst.2018.407.

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Abstract Biochar was prepared from two different types of biological waste materials, corn cob (CC) and sugarcane bagasse (SB). The adsorption capacity of each class of adsorbent was determined by chlortetracycline (CTC) adsorption tests. The adsorption kinetics and isotherms of chlortetracycline onto sugarcane bagasse biochar (SBB) and corn cob biochar (CCB) were studied. Experimental results indicated that pseudo-second-order adsorption kinetics of CTC onto SBB and CCB were more reasonable than pseudo-first-order kinetics, and the adsorption kinetic model of CTC onto SBB was slightly better than that onto CCB. The maximum adsorption capacity of CTC onto SBB was 16.96 mg/g at pH 4, while the highest adsorption efficiency of CTC onto CCB was achieved at pH 5 with a maximum adsorption of 12.39 mg/g. The Freundlich isotherm model was better than the Langmuir model at illustrating the adsorption process of CTC onto SBB and CCB. These results provide a way to understand the value of specific biochars, which can be used as efficient and effective adsorbents for CTC removal from waste-water. Compared with raw pinewood, SBB and CBB were considered as alternative materials to remove antibiotics from aqueous environments.
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Cooray, Asantha. „Extragalactic background light measurements and applications“. Royal Society Open Science 3, Nr. 3 (März 2016): 150555. http://dx.doi.org/10.1098/rsos.150555.

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This review covers the measurements related to the extragalactic background light intensity from γ-rays to radio in the electromagnetic spectrum over 20 decades in wavelength. The cosmic microwave background (CMB) remains the best measured spectrum with an accuracy better than 1%. The measurements related to the cosmic optical background (COB), centred at 1 μm, are impacted by the large zodiacal light associated with interplanetary dust in the inner Solar System. The best measurements of COB come from an indirect technique involving γ-ray spectra of bright blazars with an absorption feature resulting from pair-production off of COB photons. The cosmic infrared background (CIB) peaking at around 100 μm established an energetically important background with an intensity comparable to the optical background. This discovery paved the way for large aperture far-infrared and sub-millimetre observations resulting in the discovery of dusty, starbursting galaxies. Their role in galaxy formation and evolution remains an active area of research in modern-day astrophysics. The extreme UV (EUV) background remains mostly unexplored and will be a challenge to measure due to the high Galactic background and absorption of extragalactic photons by the intergalactic medium at these EUV/soft X-ray energies. We also summarize our understanding of the spatial anisotropies and angular power spectra of intensity fluctuations. We motivate a precise direct measurement of the COB between 0.1 and 5 μm using a small aperture telescope observing either from the outer Solar System, at distances of 5 AU or more, or out of the ecliptic plane. Other future applications include improving our understanding of the background at TeV energies and spectral distortions of CMB and CIB.
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Bentley, D. R. „Primary structure of human complement component C2 Homology to two unrelated protein families“. Biochemical Journal 239, Nr. 2 (15.10.1986): 339–45. http://dx.doi.org/10.1042/bj2390339.

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The primary structure of the second component of human complement (C2) was determined by cDNA cloning and sequence analysis. C2 has 39% identity with the functionally analogous protein Factor B. The C-terminal half of C2a is homologous to the catalytic domains of other serine proteinases. C2b contains three direct repeats of approx. 60 amino acid residues. They are homologous to repeats in Factor B, C4b-binding protein and Factor H, suggesting a functional significance of the repeat in C4b and C3b binding. The repeats are also found in the non-complement proteins beta 2-glycoprotein I and interleukin-2 receptor, and this repeat family may be widespread.
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Takata, Y., T. Kinoshita, H. Kozono, J. Takeda, E. Tanaka, K. Hong und K. Inoue. „Covalent association of C3b with C4b within C5 convertase of the classical complement pathway.“ Journal of Experimental Medicine 165, Nr. 6 (01.06.1987): 1494–507. http://dx.doi.org/10.1084/jem.165.6.1494.

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The C5 convertase of the classical complement pathway is a complex enzyme consisting of three complement fragments, C4b, C2a, and C3b. Previous studies have elucidated functional roles of each subunit (4, 6, 7), but little is known about how the subunits associate with each other. In this investigation, we studied the nature of the classical C5 convertase that was assembled on sheep erythrocytes. We found that one of the nascent C3b molecules that had been generated by the C3 convertase directly bound covalently to C4b. C3b bound to the alpha' chain of C4b through an ester bond, which could be cleaved by treatment with hydroxylamine. The ester bond was rather unstable, with a half-life of 7.9 h at pH 7.4 and 37 degrees C. Formation of the C4b-C3b dimer is quite efficient; e.g., 54% of the cell-bound C3b was associated with C4b when 25,000 molecules of C4b and 12,000 molecules of C3b were present per cell. Kinetic analysis also showed the efficient formation of the C4b-C3b dimer; the rate of dimer formation was similar to or even faster than that of cell-bound monomeric C3b molecules. These results indicate that C4b is a highly reactive acceptor molecule for nascent C3b. High-affinity C5-binding sites with an association constant of 2.1 X 10(8) L/M were demonstrated on C4b-C3b dimer-bearing sheep erythrocytes, EAC43 cells. The number of high-affinity C5-binding sites coincided with the number of C4b-C3b dimers, but not with the total number of cell-bound C3b molecules. Anti-C4 antibodies caused 80% inhibition of the binding of C5 to EAC43 cells. These results suggest that only C4b-associated C3b serves as a high-affinity C5 binding site. EAC14 cells had a small amount of high-affinity C5 binding sites with an association constant of 8.1 X 10(7) L/M, 100 molecules of bound C4b being necessary for 1 binding site. In accordance with the hypothesis that C4b-associated C4b might also serve as a high-affinity C5-binding site, a small amount of C4b-C4b dimer was detected on EAC14 cells by SDS-PAGE analysis. Taken together, these observations indicate that the high-affinity binding of C5 is probably divalent, in that C5 recognizes both protomers in the dimers. The high-affinity binding may allow selective binding of C5 to the convertase in spite of surrounding monomeric C3b molecules.
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Janowska-Wieczorek, Anna, Leah A. Marquez-Curtis, Danila Leontyev, Donald R. Branch, Janina Ratajczak und Mariusz Z. Ratajczak. „Studies in C4b-Deficient Mice Provide Further Evidence That Complement Cascade Orchestrates the Mobilization of Hematopoietic Stem/Progenitor Cells.“ Blood 120, Nr. 21 (16.11.2012): 2316. http://dx.doi.org/10.1182/blood.v120.21.2316.2316.

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Abstract Abstract 2316 Introduction: Complement cascade (CC) and innate immunity have emerged as important modulators of hematopoietic stem/progenitor cell (HSPC) trafficking. We reported that the CC becomes activated in bone marrow (BM) during HSPC mobilization induced by G-CSF or AMD3100 and proposed that the generation of C5a and C5b-C9 (membrane attack complex; MAC) is required for optimal mobilization (Stem Cells 2007; 25:3093; Leukemia 2010; 24:976). While C5a induces a proteolytic microenvironment in BM that attenuates SDF-1-CXCR4 retention signals for HSPC and promotes egress of leucocytes, C5b-C9 (MAC) induces the release of a crucial chemoattractant, sphingosine-1 phosphate (S1P), from red blood cells and augments mobilization of HSPC from BM. On the other hand, C3 cleavage fragments attenuate mobilization by enhancing responsiveness of HSPC to SDF-1 retention signals thus promoting HSPC retention in BM. Thus our findings suggest that mobilization is differently regulated by the proximal and distal parts of CC (upstream and downstream of C3, respectively). We also demonstrated that C3-deficient mice (lacking C3 cleavage fragments) are easy mobilizers whereas C5-deficient mice (lacking C5 cleavage fragments and not generating MAC) mobilize HSPC very poorly (Leukemia 2009; 23:2052). C4 is part of the classical pathway of CC whose activation/cleavage is initiated by C1 and C2, releasing smaller (C4a and C2b) and larger (C4b and C2a) fragments. C2a binds with C4b to form an enzymatic complex termed C3 convertase that cleaves C3 into C3a anaphylatoxin and C3b. Aim of Study: In the present study we investigated the role of C4 in HSPC mobilization and hypothesized that C4-deficient mice are easy mobilizers, supporting the notion that the proximal part of CC is crucial for retention of HSPC in the BM microenvironment. Experimental Approach: We employed 6–8 week old C4b-deficient mice (strain B6.129S-C4btm1Crr/J from Jackson Laboratory, Bar Harbour, ME) and wild type (WT) littermates. Mice were injected subcutaneously with 250 μg/kg of human recombinant G-CSF (Amgen, Thousand Oaks, CA) or saline (control) daily for 3 days. At 6 h after the last G-CSF injection, the mice were sacrificed and blood was collected from the vena cavae. Mobilization was evaluated by determining the number of leukocytes (WBC) and colony-forming unit granulocyte-macrophages (CFU-GM) circulating in the peripheral blood (PB). We also measured the level of mouse terminal complement complex C5b-C9 (MAC) in plasma using ELISA (Kamiya) in G-CSF-mobilized and non-mobilized C4b-deficient and WT mice. Results: We found that C4b-deficient mice treated with saline have slightly higher WBC counts than WT mice and that G-CSF induced a greater increase in WBC counts in these mice than in WT mice. Based on CFU-GM counts after G-CSF mobilization, C4b-deficient mice mobilized significantly more HSPCs into PB than WT mice (p < 0.0065). These observations were consistent in all four experiments performed involving 18–20 mice per experiment. The G-CSF mobilization responses correlated with a greater increase in activation of the distal part of CC in C4b-deficient mice compared to WT mice, as evidenced by C5b-C9 levels evaluated by ELISA. Conclusions: Our data indicate that C4-deficient mice are easy mobilizers, thus supporting a role for the proximal part of CC in retention of HSPC in BM. Furthermore, mobilization of HSPC in C4b-deficient mice correlated with activation of the distal part of CC and generation of C5b-C9 (MAC) suggesting that activation of the distal part of CC is crucial for egress of HSPCs into PB. Moreover, activation of the distal part of CC in C4-deficient mice that have defective activation of the proximal part of CC indicates that C5 may be cleaved in a C3-independent manner by other proteolytic enzymes present in blood plasma. Finally, our data further support that mobilization is part of a more general immune response in which all complement components, including C4, play a significant role. Disclosures: No relevant conflicts of interest to declare.
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Dissertationen zum Thema "Cqb"

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Reece, Jordan. „Virtual Close Quarter Battle (CQB) graphical decision trainer“. Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2002. http://library.nps.navy.mil/uhtbin/hyperion-image/02sep%5FReece.pdf.

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Vikenslätt, Seivan. „Stad i eld och rörelse – Manöverkrigföring i bebyggelse : En kvalitativ studie om manöverkrigföring i SIB“. Thesis, Försvarshögskolan, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:fhs:diva-10013.

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While the world is urbanising at an exponential rate, so does the conflicts. The common environment for a conventional military force has changed from the open fields normally dominated by tanks and artillery, to narrow streets and buildings in a city. While the actors and environment for combat changes, the tactics doesn’t seem to. Maneuver warfare was mainly developed from the lessons learned from WW2 and was focused on warfare with large units using firepower and movement. But since the last two decades most of the fighting has taken part in urban areas against another type of enemy, which won’t allow for the full extent of the maneuvering and firepower due to structures and other obstructions in a city. This study will analyse how western militaries utilised the principles of maneuver warfare in urban combat. The goal is to measure how well the principles of maneuver warfare applicable in an urban environment against the ever-increasing irregular threat. The purpose is to indicate the complexity the urban environment brings to military units when planning and conducting operations.  The results find that maneuver warfare relates well but can’t fully explain military success in urban warfare.
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Maniyar, Abhishek Sanjay. „From the CMB to CIB : dusty star formation, dark energy and kSZ“. Thesis, Aix-Marseille, 2019. http://theses.univ-amu.fr.lama.univ-amu.fr/190919_MANIYAR_759uunye462vklkb421iixa572jct_TH.pdf.

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Le fond diffus infrarouge (CIB) provient de l'émission IR cumulée des galaxies sur toute l'histoire de l'Univers. Ainsi, le CIB sonde la formation et l'évolution des galaxies sur une grande gamme de décalage vers le rouge. Dans cette thèse, nous utilisons les anisotropies du CIB pour: i) Mesurer l'histoire de la formation des étoiles de l'Univers et le biais effectif des halos de matière noire hébergeant les galaxies CIB jusqu'à un décalage rouge élevé. En utilisant ces mesures, nous calculons la masse typique de ces halos de matière noire, sur une grande gamme de décalage vers le rouge. ii) En utilisant le CIB comme traceur de la structure à grande échelle, la corrélation croisée avec le CMB fournit une sonde alternative de l'énergie noire. Nous montrons que le CIB, extrait sur une grande fraction du ciel, peut fournir la meilleure mesure de l'effet ISW. En utilisant un formalisme matriciel de Fisher, nous prédisons l'amélioration des contraintes sur les paramètres cosmologiques en utilisant l'ISW mesuré avec le CIB. iii) Mesurer le spectre de puissance de l'effet Sunyaev-Zel'dovich cinétique (kSZ) caché dans les données du CMB. Nous améliorons les analyses existantes en combinant les mesures du CIB (de Planck/HFI et Herschel/SPIRE) et les observations de Planck, SPT et ACT pour étendre la gamme des échelles spatiales et des fréquences afin de faciliter la mesure du kSZ. Nous développons un nouveau modèle pour le CIB (pour pouvoir tenir compte des petites échelles spatiales), et modélisons de façon cohérente l'effet SZ thermique (tSZ) et la corrélation CIBxtSZ. Ceci est nécessaire pour séparer avec précision ces différentes composantes dans le spectre de puissance
The CIB is the cumulative infrared emission from all the galaxies throughout cosmic history. Its distinct frequency-redshift dependence allows to probe a large span of redshifts. In this thesis, we utilise the CIB anisotropies detected by the Planck satellite to:i) Measure the star formation history of the Universe and the effective bias of the dark matter halos hosting the CIB galaxies to a high redshift. Using these measurements, we calculate the typical mass of the host dark matter halos for the CIB galaxies at different times.ii) Using the CIB as a tracer of the large scale structure, the cross-correlation with the CMB provides with an alternative probe of the dark energy. We showed that the CIB, extracted on a large fraction of the sky, may provide the best Integrated Sachs Wolf measurement (in terms of S/N ratio). Using a Fisher matrix formalism, we also predict the improvement on the constraints on the cosmological parameters using the ISW measured with this technique. We cross-correlate the best available maps of the CIB and the CMB and find that the dust residuals in the CIB maps are too high to detect the ISW through this method.iii) Measure the kinetic Sunyaev-Zel'dovich (kSZ) power spectrum hidden in the CMB power spectrum. We improve upon the existing analysis by combining the CIB measurements (from Planck/HFI and Herschel/SPIRE) and multi-frequency observations by Planck, SPT and ACT to extend the range of scales and frequencies to facilitate the kSZ measurement. We develop a power spectrum analysis based on physically motivated but simplistic and consistent models of foreground components (CIB, tSZ, tSZxCIB) to accurately separate the kSZ from the CMB
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Paramaswara, Bamini. „Characterization of the promoter for the human factor I (C3b/C4b inactivator) gene“. Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ34077.pdf.

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Jakob, Stephan Mathias. „Klinische und biochemische Aspekte des vollständigen, hereditären Komplement Faktor I-(C3b/C4b-Inaktivor)Mangels /“. Bern, 1990. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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Kucukkilic, Ezgi. „Copy number variation and relevance to disease of the complement C3b/C4b receptor 1 (CR1) gene“. Thesis, University of Leicester, 2017. http://hdl.handle.net/2381/40701.

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The complement 3b/4b receptor 1 (CR1) gene is located at chromosome 1q32.2 in a cluster of complement-related genes. CR1 regulates both classical and alternative pathways of the complement system. CR1 is a major receptor for Plasmodium falciparum, and variation within the gene has been associated with different malarial clinical phenotypes. CR1 shows intragenic copy number variation (CNV) resulting in variation in protein length and number of C3b/C4b binding domains. Previously, CR1 was related to Alzheimer’s disease (AD) via complement system regulation. Furthermore, CR1 variation is responsible for the alleles of the Knops blood group, including McCoy and Swain-Langley. In this thesis, Novel paralogue ratio test (PRT) assays were developed to robustly type CNV of the low-copy repeat (LCR) regions (which defines the common CR1-A and CR1-B alleles, but also rarer alleles) within the gene in large cohorts, and an allele-specific hybridisation assay to genotype alleles of the Knops blood group system. Variation was analysed across global populations, and in the Tori-Bossito cohort (563 infants) from Benin, followed since birth to observe malaria acquisition and treatment. This showed that the Swain-Langley Sl2 polymorphism is not in strong linkage disequilibrium (LD) with the CNV, nor with other Knops blood group alleles. It appears to provide protection against early acquisition of malaria and subsequent number of malarial infections in the Tori-Bossito cohort but these results were not confirmed in an independent cohort (n=276). The association between the CR1-B allele and AD (early-onset (EOAD) and late-onset (LOAD)) was explored, showing that the CR1 risk loci (rs3818361, rs6656401 (only for EOAD) and rs6701713) were in moderate LD with CR1-B, but revealing no association between CR1-B (p=0.755) and EOAD (n=633). However, the CR1-B allele (risk) appears to be associated with LOAD (n=2185) with (p=0.015) and without (p=0.048) use of a junction fragment PCR assay.
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Kisserli, Aymric. „Distribution, rôle et régulation du CRI (CD35, récepteur pour le C3b/C4b) érythrocytaire. Analyse de dépôts érythrocytaires de fractions du complément“. Reims, 2008. http://theses.univ-reims.fr/exl-doc/GED00000886.pdf.

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CR1 (CD35, récepteur pour le C3b/C4b) est une glycoprotéine transmembranaire présente sur de nombreux types cellulaires. Son rôle principal à la surface des érythrocytes (E) est le transport des complexes immuns vers le foie et la rate où ils sont éliminés. Nous avons montré que le Macaque rhésus (Macaca mulatta, MM) exprime un CR1 équivalent à celui de l’Homme en taille, en densité et réparti en bouquets. Ce CR1 présente des polymorphismes allotypiques. Il exprime aussi un CR1 plus court (CR1like, CR1L), plus abondant, plus diffus, à ancrage glycophosphatidylinositol. Nous avons décrit des polymorphismes de la région Sla de CR1 impliquée dans les phénomènes d'adhérence inter-érythrocytaire entre les E parasités par P. Falciparum et les E sains chez 12 espèces de primates. Ils ne protègent pas les E de MM contre la formation des rosettes avec des E humains parasités. Nous avons séquencé les promoteurs de CR1 et CR1L de MM (MCR1, MCR1L). AML1 activateur de CR1 humain est présent dans MCR1 mais absent de MCR1L. Ets et MZF1 sont conservés. Nous avons identifié un polymorphisme allèlique (délétion de 18 nucléotides) dans CR1L humain. Nous avons étudié le dépôt de C4d érythrocytaire (EC4d) de transplantés rénaux concomitamment à l'analyse de la biopsie du greffon. Il existe une relation entre le EC4d et le marquage diffus C4d des capillaires péritubulaires du greffon ; et entre le EC4d et les lésions histologiques retrouvées en situation de rejet aigu humoral. Le EC4d offre un intérêt pour le diagnostic et le suivi des rejets en transplantation rénale. Le mécanisme des dépôts de C4d reste à élucider. L’activation de la voie classique du complément ne semble pas impliqué
@CR1 (CD35, the C3b/C4b receptor) is a transmembrane glycoprotein found on few cell types. Erythrocyte CR1 (E-CR1) is involved in immune complex (IC) clearance in liver and spleen. The binding of IC on E is improved by cluster distribution of CR1 enabling a strong avidity multivalent binding. Rhesus macaque (Macaca mulatta) was shown to express a transmembrane E-CR1 as observed in Human (same length, density, cluster distribution). This “human-type” CR1 was characterized by allotypic polymorphisms. A shorter CR1 was also observed, called CR1like (CR1L) which was more abundant, more diffuse and glycophosphatidylinositol anchored. Polymorphisms of CR1 Sla region involved in rosetting between healthy E and P. Falciparum infected E were described in 12 primate species. E from rhesus macaque were not prevented from rosetting with human infected E by those polymorphisms. CR1 and CR1L promoters from rhesus macaque (MCR1, MCR1L) were sequenced. AML1 known as human CR1 activator was found in MCR1 but was missing in MCR1L. Ets and MZF1 were conserved. HES1 et LBP1 might downregulate MCR1 and human CR1L. An allelic polymorphism corresponding to a 18 nucleotide deletion was observed in human CR1L promoter. C4d deposition at E surface (EC4d) of patients suffering from kidney acute humoral rejection was compared with biopsy analysis and related to C4d tissue deposits. EC4d appears a promising non-invasive marker of acute humoral rejection. The mechanism of C4d deposition remains to be investigated. Complement classical pathway activation did not seem to be involved
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Pedrazzi, Pietro. „Studio della sostenibilità ambientale nel ciclo di vita di un edificio in terra cruda in Mali“. Master's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/21503/.

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Questa tesi mira a valutare la sostenibilità ambientale ed economica di una scuola di tre classi, costruita in mattoni di terra cruda compressa a Dougourakoro, in Mali, seguendo i principi della progettazione bioclimatica. A questo scopo, è stata condotto uno studio LCA che compara due diversi casi di studio: l’edificio bioclimatico in mattoni compressi di terra cruda ed un edificio in mattoni forati di cemento, che rispecchia la tipologia costruttiva maggiormente diffusa localmente. L’utilizzo della terra cruda come materiale da costruzione, infatti, è stato localmente soppiantato negli ultimi decenni da mattoni in cemento che necessitano di una minore manutenzione. I risultati dell’analisi LCA indicano un minore impatto ambientale dell’edificio in terra cruda, che si crede possa essere ulteriormente accentuato da una futura inclusione nell’analisi della fase di uso. I maggiori costi che è necessario sostenere durante la costruzione corrispondono ad una maggiore quantità dei materiali utilizzati e ad una superiore complessità delle lavorazioni durante la costruzione. Sintetizzando i risultati, si conclude che, nonostante l’edificio in terra cruda abbia un minore impatto ambientale, il potenziale inespresso di questo materiale è ancora altissimo, potendo manifestarsi appieno, però, solo dopo una rinnovata accettazione sociale, stimolata attraverso attività formative in loco che potrebbero portare ad una maggiore diffusione di conoscenze, conoscenze e macchinari legati a questo materiale, abbattendone così, i costi di produzione e costruzione.
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Dole, Herve. „La nuit n'est pas noire: le rayonnement de fond extragalactique et l'évolution des galaxies infrarouges“. Habilitation à diriger des recherches, Université Paris Sud - Paris XI, 2010. http://tel.archives-ouvertes.fr/tel-00529539.

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L'Univers, en dehors de notre Galaxie, est baigné de nombreux rayonnements, le principal étant observable dans le domaine des ondes radio centimétriques et millimétriques: le fond cosmologique (ou CMB pour {\it Cosmic Microwave Background}), corps noir de température actuelle 2.7 Kelvin. Découvert dans les années soixante, et largement étudié depuis pour ses infimes fluctuations de température et de polarisation, il se propage librement depuis une époque située environ 400000 ans après le big-bang. Il nous renseigne sur l'état de l'Univers primordial, sur son contenu, ainsi que sur certains processus physiques ayant eu lieu ultérieurement, comme la réionisation ou la formation des amas de galaxie. Un autre rayonnement d'importance cosmologique a été découvert il y a seulement quatorze ans dans les données du satellite COBE, mais ici dans le domaine de l'infrarouge lointain, vers 200 microns de longueur d'onde: le {\bf rayonnement fossile des galaxies}, ou fond diffus extragalactique infrarouge. Il est environ 50 fois moins intense que le fond cosmologique (pic à pic, ou de 20 à 40 fois moins en intégrale). Cette détection a constitué une grande surprise vu la grande intensité relative de l'infrarouge lointain par rapport à la partie visible provenant directement des étoiles. Ce fond diffus a pour origine l'émission de toutes les galaxies depuis leur formation, et résume ainsi toute leur histoire. Il est donc permis d'écrire, presque sans ironie, que {\bf la nuit n'est pas noire}, dans la mesure où, si nos yeux (avec le concours d'une hypothétique fenêtre atmosphérique) étaient sensibles aux rayonnements infrarouge lointain, millimétrique et centimétrique, ils verraient une nuit brillante de rayonnements cosmologiques. Notons que la question de la nuit noire - connue sous le nom de paradoxe d'Olbers Chéseaux - est ancienne, fertile, et touche aux fondements de la description et la compréhension de notre Univers physique, de son origine et de son évolution. Mesurer précisément ce rayonnement de fond infrarouge et comprendre la nature des galaxies qui en sont à l'origine et leur évolution, constituent l'une des thématiques importantes de la cosmologie observationnelle d'aujourd'hui. Je détaille, dans ce manuscrit de HDR, quelques-unes de mes contributions à l'étude statistique des galaxies infrarouges, à la mesure et l'interprétation du rayonnement extragalactique, et esquisse quelques perspectives. Le document de la HDR -- soutenue le 21 septembre 2010 à l'Institut d'Astrophysique Spatiale, Orsay -- et ses annexes sont disponibles en ligne sur http://www.ias.u-psud.fr/dole/hdr/
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Rossi, Urquijo Javier, und Arnaldo Cano. „Advantage in Cab“. Tesis, Universidad de Chile, 2017. http://repositorio.uchile.cl/handle/2250/147743.

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TESIS PARA OPTAR AL GRADO DE MAGÍSTER EN ADMINISTRACIÓN
Javier Rossi Urquijo [Parte I Análisis estratégico y de mercado], Arnaldo Cano [Parte II Análisis organizativo y financiero]
AdVantage in Cab, es un proyecto innovador que busca hacer converger tanto la evolución tecnológica en la que se encuentra la sociedad actualmente y las necesidades de 2 actores claves para el desarrollo adecuado del proyecto. Posesionados desde la demanda, se detecta la necesidad de modernización y asesoría tecnológica de los gremios de taxis convencionales incluyendo en su oferta soluciones tecnológicas como la propuesta. Por otra parte, y para poder financiar la propuesta, se detecta la necesidad creciente de las agencias publicitarias de poder segmentar cada vez con mayor exactitud, las exposiciones de sus campañas. Dado lo anterior, AdVantage in Cab ofrece una plataforma para difusión publicitaria al interior de los taxis convencionales, a través de Tablet instaladas en la parte posterior del asiento del copiloto, la cual proyecta campañas dependiendo del sector y el pasajero que contrata el servicio de transporte. Dicha Tablet es capaz de realizar una estimación de sexo y rango etario del pasajero con la finalidad de segmentar posteriormente la publicidad emitida y direccionar lo que las agencias necesiten. El análisis de la industria entrega resultados favorables, lo que, complementado con el aumento en la inversión en publicidad digital en Chile, que en la última década pasó de 1,4 a 14,7% del total invertido, aumenta las posibilidades de éxito. En cuanto al análisis financiero se aprecia un horizonte de maduración del negocio de 5 años, logrando al año 3 un VAN estimado de $11 MM.
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Bücher zum Thema "Cqb"

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CQB: Close quarter battle. London: Corgi Books, 1998.

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CQB: Close quarter battle. London: Bantam Press, 1997.

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battle), CQB (close quarter, und Specialized Tactical Training Unit (Los Angeles, Calif.), Hrsg. CQB, a guide to unarmed combat and close quarter shooting. Los Angeles, CA, U.S.A: S.T.T.U., 1991.

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Paramaswara, Bamini. Characterization of the promoter for the human factor I (C3b/C4b inactivator) gene. Ottawa: National Library of Canada, 1998.

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America, Boy Scouts of. Cub Scout Tiger Cub handbook. Irving, Tex: Boy Scouts of America, 2001.

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Updike, Ken. Original Farmall Cub and Cub Cadet. St. Paul, Minn: MBI Pub., 2005.

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Updike, Ken. Original Farmall Cub and Cub Cadet. St. Paul, Minn: MBI Pub., 2006.

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Davodoun, Comlan Cyr. Étude comparée: Du certificat de qualification professionnelle (CQP) et du certificat de qualification aux métiers (CQM). Cotonou, Benin: Bureau d'appui aux artisans, 2014.

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Segura, Antonio. Burton & CYB. New York: Catalan Communication, 1991.

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Cob dār. Faiṣalābād: Mis̲āl Pablisharz, 2008.

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Buchteile zum Thema "Cqb"

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Hyderkhan, Scott. „Close Quarter Battle (CQB)“. In Active Shooter Response Training, 61–62. Second edition. | New York, NY: Routledge, 2020. |: Routledge, 2020. http://dx.doi.org/10.4324/9780429282188-5.

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Varde, P. V., und Arihant Jain. „CQB—A New Approach for Human Factor Modeling“. In Reliability, Safety and Hazard Assessment for Risk-Based Technologies, 743–50. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-9008-1_63.

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Gooch, Jan W. „CAB“. In Encyclopedic Dictionary of Polymers, 107. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_1781.

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Gooch, Jan W. „CAB“. In Encyclopedic Dictionary of Polymers, 107. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_1782.

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Peters, Nils, Martin Dichgans, Sankar Surendran, Josep M. Argilés, Francisco J. López-Soriano, Sílvia Busquets, Klaus Dittmann et al. „CSB“. In Encyclopedia of Molecular Mechanisms of Disease, 473. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_5050.

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Mehlhorn, Heinz. „CLB“. In Encyclopedia of Parasitology, 517. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-43978-4_4128.

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Mehlhorn, Heinz. „CLB“. In Encyclopedia of Parasitology, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27769-6_4128-1.

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Viso, Michel. „CAB, Spain“. In Encyclopedia of Astrobiology, 1–2. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-27833-4_1770-3.

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Viso, Michel. „CAB, Spain“. In Encyclopedia of Astrobiology, 346–47. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-44185-5_1770.

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Peroulis, Dimitrios, Prashant R. Waghmare, Sushanta K. Mitra, Supone Manakasettharn, J. Ashley Taylor, Tom N. Krupenkin, Wenguang Zhu et al. „Cob Web“. In Encyclopedia of Nanotechnology, 457. Dordrecht: Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-90-481-9751-4_100152.

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Konferenzberichte zum Thema "Cqb"

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Lembo, Domenico, Riccardo Rosati und Domenico Fabio Savo. „Revisiting Controlled Query Evaluation in Description Logics“. In Twenty-Eighth International Joint Conference on Artificial Intelligence {IJCAI-19}. California: International Joint Conferences on Artificial Intelligence Organization, 2019. http://dx.doi.org/10.24963/ijcai.2019/247.

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Controlled Query Evaluation (CQE) is a confidentiality-preserving framework in which private information is protected through a policy, and a (optimal) censor guarantees that answers to queries are maximized without violating the policy. CQE has been recently studied in the context of ontologies, where the focus has been mainly on the problem of the existence of an optimal censor. In this paper we instead consider query answering over all possible optimal censors. We study data complexity of this problem for ontologies specified in the Description Logics DL-LiteR and EL_bottom and for variants of the censor language, which is the language used by the censor to enforce the policy. In our investigation we also analyze the relationship between CQE and the problem of Consistent Query Answering (CQA). Some of the complexity results we provide are indeed obtained through mutual reduction between CQE and CQA.
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Fu, Lin, Dion Hoe-Lian Goh und Schubert Shou-Boon Foo. „CQE“. In the 5th ACM/IEEE-CS joint conference. New York, New York, USA: ACM Press, 2005. http://dx.doi.org/10.1145/1065385.1065481.

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Singh, Amit, und Karthik Visweswariah. „CQC“. In the 20th ACM international conference. New York, New York, USA: ACM Press, 2011. http://dx.doi.org/10.1145/2063576.2063883.

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Yan, Bo, Yang Xu, Hongya Xing, Kang Xi und H. Jonathan Chao. „CAB“. In SIGCOMM'14: ACM SIGCOMM 2014 Conference. New York, NY, USA: ACM, 2014. http://dx.doi.org/10.1145/2620728.2620732.

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Li, Guoliang, Chengliang Chai, Ju Fan, Xueping Weng, Jian Li, Yudian Zheng, Yuanbing Li, Xiang Yu, Xiaohang Zhang und Haitao Yuan. „CDB“. In SIGMOD/PODS'17: International Conference on Management of Data. New York, NY, USA: ACM, 2017. http://dx.doi.org/10.1145/3035918.3064036.

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Lomotey, Richard K., und Ralph Deters. „CSB-UCC“. In the Fifth International Conference. New York, New York, USA: ACM Press, 2013. http://dx.doi.org/10.1145/2536146.2536173.

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Dickinson, Clive. „CMB interferometry“. In Resolving The Sky - Radio Interferometry: Past, Present and Future. Trieste, Italy: Sissa Medialab, 2012. http://dx.doi.org/10.22323/1.163.0034.

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Kimura, Masaomi. „CAB-NC“. In ASONAM '19: International Conference on Advances in Social Networks Analysis and Mining. New York, NY, USA: ACM, 2019. http://dx.doi.org/10.1145/3341161.3342944.

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Shi, Runbin, Peiyan Dong, Tong Geng, Yuhao Ding, Xiaolong Ma, Hayden K. H. So, Martin Herbordt, Ang Li und Yanzhi Wang. „CSB-RNN“. In ICS '20: 2020 International Conference on Supercomputing. New York, NY, USA: ACM, 2020. http://dx.doi.org/10.1145/3392717.3392749.

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Gosavi, Santosh S. „In Lab Truck Cab and Cab Suspension Durability Validation“. In SAE 2006 World Congress & Exhibition. 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 2006. http://dx.doi.org/10.4271/2006-01-1245.

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Berichte der Organisationen zum Thema "Cqb"

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Kalyan Annamalai, John Sweeten, Saqib Mukhtar, Ben Thein, Gengsheng Wei, Soyuz Priyadarsan, Senthil Arumugam und Kevin Heflin. CO-FIRING COAL: FEEDLOT AND LITTER BIOMASS (CFB AND CLB) FUELS IN PULVERIZED FUEL AND FIXED BED BURNERS. Office of Scientific and Technical Information (OSTI), August 2003. http://dx.doi.org/10.2172/822025.

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Damman, Dennis. Cab Heating and Cooling. Office of Scientific and Technical Information (OSTI), Oktober 2005. http://dx.doi.org/10.2172/903061.

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Garvin, L. J. Canister storage building (CSB) safety analysis report phase 3: Safety analysis documentation supporting CSB construction. Office of Scientific and Technical Information (OSTI), April 1997. http://dx.doi.org/10.2172/16912.

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REED, A. V. Evaluation of CSB Cask Receipt Pressure. Office of Scientific and Technical Information (OSTI), August 1999. http://dx.doi.org/10.2172/797705.

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Abazajian, Kevork N. CMB-S4 Science Book, First Edition. Office of Scientific and Technical Information (OSTI), Oktober 2016. http://dx.doi.org/10.2172/1352047.

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Abitbol, Maximilian H. CMB-S4 Technology Book, First Edition. Office of Scientific and Technical Information (OSTI), Juni 2017. http://dx.doi.org/10.2172/1414402.

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K. C. Seino. CUB DI (Deionization) column control system. Office of Scientific and Technical Information (OSTI), Juli 1999. http://dx.doi.org/10.2172/8368.

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Sheikh, Ahmad, und Zachary Brewer. Sternotomy and Cardio-Pulmonary Bypass (CPB). Touch Surgery Simulations, Dezember 2014. http://dx.doi.org/10.18556/touchsurgery/2014.s0036.

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HOLLENBECK, R. G. Analysis for Eccentric Multi Canister Overpack (MCO) Drops at the Canister Storage Building (CSB) (CSB-S-0073). Office of Scientific and Technical Information (OSTI), Juni 2000. http://dx.doi.org/10.2172/803964.

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TU, K. C. Analysis for Eccentric Multi Canister Overpack (MCO) Drops at the Canister Storage Building (CSB) (CSB-S-0073). Office of Scientific and Technical Information (OSTI), Oktober 1999. http://dx.doi.org/10.2172/798142.

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