Auswahl der wissenschaftlichen Literatur zum Thema „Composante inflammatoire“
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Zeitschriftenartikel zum Thema "Composante inflammatoire"
Ghizlene, Laachir, Najioullah Dounia, Kabajj Najat und El Quessar Abdeljalil. „ENCEPHALITE DE RASMUSSEN CAUSE RARE DE LEPILEPSIE CHEZ LENFANT A PROPOS DUN CAS“. International Journal of Advanced Research 9, Nr. 08 (31.08.2021): 61–64. http://dx.doi.org/10.21474/ijar01/13230.
Der volle Inhalt der QuelleVuong, P. N., S. Wanji, J. Prod'Hon und O. Bain. „Nodules sous-cutanés et lésions cutanées engendrés par diverses onchocerques chez des bovins africains“. Revue d’élevage et de médecine vétérinaire des pays tropicaux 47, Nr. 1 (01.01.1994): 47–51. http://dx.doi.org/10.19182/remvt.9131.
Der volle Inhalt der QuelleTalmont, Franck, Anastassia Hatzoglou und Olivier Cuvillier. „La sclérose en plaques et les médicaments immuno-modulateurs des récepteurs de la sphingosine 1-phosphate“. médecine/sciences 36, Nr. 3 (März 2020): 243–52. http://dx.doi.org/10.1051/medsci/2020026.
Der volle Inhalt der QuelleHiram, R., E. Rizcallah, C. Sirois, M. Sirois, C. Morin und E. Rousseau. „La réduction de la composante inflammatoire par la Résolvine D1 réduit l’hyperréactivité des artères pulmonaires humaines“. Revue des Maladies Respiratoires 32, Nr. 3 (März 2015): 308–9. http://dx.doi.org/10.1016/j.rmr.2015.02.016.
Der volle Inhalt der QuelleBauvois, Adeline, Mélusine Larivière, Hervé Watier und François Maillot. „Actualités des anticorps monoclonaux dans les maladies monogéniques aujourd’hui“. médecine/sciences 35, Nr. 12 (Dezember 2019): 1026–28. http://dx.doi.org/10.1051/medsci/2019203.
Der volle Inhalt der QuelleOkombe Embeya, Victor, und Gaël Nzuzi Mavungu. „Evaluation de l’activité antipyrétique, analgésique et anti-inflammatoire de l’extrait méthanolique de Vitex congolensis De Wild. & T. Durand“. International Journal of Biological and Chemical Sciences 13, Nr. 7 (08.02.2020): 3066–78. http://dx.doi.org/10.4314/ijbcs.v13i7.8.
Der volle Inhalt der QuelleMonzango, Guy Lambert Sibo, Justin Esimo Mboloko, Arsène Lobota Mputu, Emmanuel Nzau Ngoma, Laetitia Monka Itewa, Maxime Fastrez und Emile Darai. „Endométriose et supplémentation nutritionnelle : une revue de littérature“. Annales Africaines de Medecine 15, Nr. 2 (30.04.2022): e4605-e4613. http://dx.doi.org/10.4314/aamed.v15i2.9.
Der volle Inhalt der QuelleDubernat, Laure, Lucie Marousez, Jean-Luc Desseyn, Valérie Gouyer, Emmanuel Hermann, Frédéric Gottrand, Delphine Ley und Jean Lesage. „Les oligosaccharides du lait maternel : des rôles majeurs pour le développement de l’enfant et sa santé future“. médecine/sciences 39, Nr. 11 (November 2023): 869–75. http://dx.doi.org/10.1051/medsci/2023164.
Der volle Inhalt der QuelleHugot, JP, P. Laurent-Puig und G. Thomas. „La composante génétique des maladies inflammatoires du tube digestif“. médecine/sciences 12, Nr. 5 (1996): 643. http://dx.doi.org/10.4267/10608/796.
Der volle Inhalt der QuelleFontanilla, Paula, Simon Willaume, Benoit Thézé, Angela Moussa, Gaëlle Pennarun und Pascale Bertrand. „Le vieillissement“. médecine/sciences 36, Nr. 12 (Dezember 2020): 1118–28. http://dx.doi.org/10.1051/medsci/2020241.
Der volle Inhalt der QuelleDissertationen zum Thema "Composante inflammatoire"
Faucher, Geneviève. „Étude de la composante génétique de l'état inflammatoire associé à l'obésité“. Thesis, Université Laval, 2010. http://www.theses.ulaval.ca/2010/27311/27311.pdf.
Der volle Inhalt der QuelleMartineau, Sabrina. „Etude des mécanismes moléculaires de l'épidermolyse bulleuse simple à partir de cellules souches humaines induites à la pluripotence“. Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASQ020.
Der volle Inhalt der QuelleEpidermolysis bullosa simplex (EBS) is a skin disorder caused mainly by dominant mutations in genes coding for keratin 5 (KRT5) or 14 (KRT14) genes. It is characterized by the presence of blisters caused by epidermal detachment, and by other complications such as cutaneous inflammation. From a genetic point of view, the mutations will alter the assembly of the keratin intermediate filament network in basal keratinocytes of the epidermis, leading to cell cytolysis and the formation of intra-epidermal blisters. Currently no effective therapeutic approach it is available. Understanding of the disease and the development of therapies have been hampered by the lack and limitations of relevant human cell and mouse models.So, the general aim of my thesis was to exploit the properties of human induced pluripotent stem cells (hiPSc) to modelling EBS. For this purpose, we generate hiPSc-derived keratinocytes from EBS patients carrying KRT5 mutations (Ker-EBS), and from healthy patients (Ker-WT). Comparison of Ker-EBS and Ker-WT enabled to show that Ker-EBS recapitulates the main phenotypes associated with EBS, namely decreased cell proliferation, increased cell migration, altered signalling pathways (ERK and JNK), as well as aggregates of intermediate keratin filaments in the cytoplasm, as observed in primary EBS keratinocytes. These results demonstrate that our hiPSc-derived cell model is relevant for study EBS.In order to identify new molecular mechanisms, a trancriptomic analysis comparing Ker-EBS with Ker-WT revealed 138 deregulated genes, revealing an enrichment in processes linked to the extracellular matrix, DNA packaging and the inflammatory response. As the inflammatory component in EBS has been poorly described, my next step was to study the pro-inflammatory cytokine phenotype. Thus, we were able to demonstrate increased expression of IL-1α, IL-1β, IL-6, IL-8 (CXCL8), CXCL5, CXCL10, CXCL11, CCL5 in Ker-EBS, at RNA level under basal or IFNy-stimulated conditions to mimic a pro-inflammatory context. Only the chemokines CXCL10 and CXCL11 are secreted at high concentrations in the culture supernatants of stimulated and unstimulated Ker-EBS, demonstrating the involvement of these cytokines in EBS.In parallel, in order to avoid biases due to genetic background, gender, patient age and epigenetics, we generated an isogenic Ker-EBS line (corrected Ker-EBS) using the CRISPR-Cas9 technique. We were thus able to demonstrate that the corrected Ker-EBS line showed a restoration of the expression level of the pro-inflammatory cytokines mentioned above, to a level close to that of Ker-WT, confirming a direct link between mutations in the KRT5 gene and the pro-inflammatory signature.In conclusion, our new cellular model enabled us to reproduce the pathological phenotypes known in the literature, and to demonstrate deregulation of pro-inflammatory cytokine expression in EBS, notably CXCL10 and CXCL11. Taken together, these results make this model a relevant tool to allow a better understanding of the molecular mechanisms associated with the pathology, particularly the inflammatory component, paving the way for new therapeutic approaches
Riollet, Céline. „Analyse des composants cellulaires et moleculaires de la reponse inflammatoire dans la glande mammaire bovine, induite par l'infection et l'immunisation“. Rennes, Agrocampus Ouest, 2000. http://www.theses.fr/2000NSARB115.
Der volle Inhalt der QuelleKouloura, Eirini. „Phytochemical investigation of Acronychia species using NMR and LC-MS based dereplication and metabolomics approaches“. Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05P636/document.
Der volle Inhalt der QuelleMedicinal plants constitute an unfailing source of compounds (natural products – NPs) utilised in medicine for the prevention and treatment of various deceases. The introduction of new technologies and methods in the field of natural products chemistry enabled the development of high throughput methodologies for the chemical composition determination of plant extracts, evaluation of their properties and the exploration of their potentials as drug candidates. Lately, metabolomics, an integrated approach incorporating the advantages of modern analytical technologies and the power of bioinformatics has been proven an efficient tool in systems biology. In particular, the application of metabolomics for the discovery of new bioactive compounds constitutes an emerging field in natural products chemistry. In this context, Acronychia genus of Rutaceae family was selected based on its well-known traditional use as antimicrobial, antipyretic, antispasmodic and anti-inflammatory therapeutic agent. Modern chromatographic, spectrometric and spectroscopic methods were utilised for the exploration of their metabolite content following three basic axes constituting the three chapters of this thesis. Briefly, the first chapter describes the phytochemical investigation of Acronychia pedunculata, the identification of secondary metabolites contained in this species and evaluation of their biological properties. The second chapter refers to the development of analytical methods for the identification of acetophenones (chemotaxonomic markers of the genus) and to the dereplication strategies for the chemical characterisation of extracts by UHPLC-HRMSn. The third chapter focuses on the application of metabolomic methodologies (LC-MS & NMR) for comparative analysis (between different species, origins, organs), chemotaxonomic studies (between species) and compound-activity correlations