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Zeitschriftenartikel zum Thema "Committee for Men Blinded in Battle"
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van Wees, Hans. „The Homeric Way of War: The Iliad and the Hoplite Phalanx (II)“. Greece and Rome 41, Nr. 2 (Oktober 1994): 131–55. http://dx.doi.org/10.1017/s0017383500023366.
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Even more than the noise and the clouds of dust raised by men and horses, the flashing of bronze armour and weapons is characteristic of Homeric panoramas of battle. When the Greeks armed themselves with helmets, shields, corslets and spears, the brightness lit up the sky, and all around the earth beamed in the shine of bronze (19.359–63). It blinded eyes, the glare of bronze from shining helmets, newly-polished corslets and bright shields, as they advanced in their masses (14.340–3).
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GARNER, JASON. „Separated by an ‘Ideological Chasm’: The Spanish National Labour Confederation and Bolshevik Internationalism, 1917–1922“. Contemporary European History 15, Nr. 3 (19.07.2006): 293–326. http://dx.doi.org/10.1017/s0960777306003341.
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This article covers the relationship between the National Labour Confederation of Spain and the Comintern and its union adjunct the Profintern, from the Confederation's initial support for the October Revolution to its subsequent outright rejection of communist politics, with reference to the positions adopted by revolutionary syndicalist movements in other countries. During this period a small number of individuals attempted to tie the Confederation to the Communist International, but failed. The article covers an important period in Spanish labour history, and helps to explain the mistrust that would bedevil the Spanish revolutionary working-class movement until the Civil War. Previous research has presented the battle for control of the CNT as a straightforward battle between anarchists and communists. This was not the case. The pro-communists were a miniscule faction, led by men recently affiliated to the CNT and who had no understanding of the depth of rejection of politics by Confederal militants. They only managed to take control of the national committee by chance. Aware of their weakness they were forced to act in a secretive and often underhand manner. Using material not consulted in previous studies this article shows the extent of their subterfuge and of the opposition this created in the Confederation, as well as demonstrating that the CNT was not the only revolutionary organisation to reject the Bolshevik International.
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O'Neill, J. P., M. Moynagh, E. Kavanagh und T. O'Dwyer. „Prospective, blinded trial of whole-body magnetic resonance imaging versus computed tomography positron emission tomography in staging primary and recurrent cancer of the head and neck“. Journal of Laryngology & Otology 124, Nr. 12 (11.06.2010): 1274–77. http://dx.doi.org/10.1017/s0022215110001398.
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AbstractObjectives:To compare the use of computed tomography – positron emission tomography and whole-body magnetic resonance imaging for the staging of head and neck cancer.Patients and methods:From January to July 2009, 15 consecutive head and neck cancer patients (11 men and four women; mean age 59 years; age range 19 to 81 years) underwent computed tomography – positron emission tomography and whole-body magnetic resonance imaging for pre-therapeutic evaluation. All scans were staged, as per the American Joint Committee on Cancer tumour–node–metastasis classification, by two blinded consultant radiologists, in two sittings. Diagnoses were confirmed by histopathological examination of endoscopic biopsies, and in some cases whole surgical specimens.Results:Tumour staging showed a 74 per cent concordance, node staging an 80 per cent concordance and metastasis staging a 100 per cent concordance, comparing the two imaging modalities.Conclusion:This study found radiological staging discordance between the two imaging modalities. Whole-body magnetic resonance imaging is an emerging staging modality with superior visualisation of metastatic disease, which does not require exposure to ionising radiation.
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Dinneen, Eoin, Jack Grierson, Aiman Haider, Alex Freeman, Jonathan Aning, Rajendra Persad, Neil Oakley, Imran Ahmad, Lorenzo Dutto und Greg Shaw. „A single-blinded, multicenter, randomized controlled trial to evaluate NeuroSAFE robotic-assisted radical prostatectomy (RARP) versus standard robotic-assisted radical prostatectomy (RARP) in men with localized prostate cancer: NeuroSAFE PROOF—Trial in progress.“ Journal of Clinical Oncology 39, Nr. 6_suppl (20.02.2021): TPS262. http://dx.doi.org/10.1200/jco.2021.39.6_suppl.tps262.
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TPS262 Background: Robot-assisted radical prostatectomy (RARP) offers cure for localised prostate cancer but is associated with considerable toxicity. Potency and urinary continence are improved when the neurovascular bundles (NVBs) are preserved during a nerve-sparing (NS) RARP. The NeuroSAFE (intra-operative frozen section examination of the neurovascular structure adjacent prostate margin) seeks to promote optimal NS to maximise the opportunity for functional recovery without jeopardising oncological safety. The NeuroSAFE technique in RP has never been evaluated against a standard of care in an randomised controlled trial. Methods: This is a pragmatic, multicentre, single-blinded randomised controlled trial (RCT) in which men are allocated in a 1:1 ratio to NeuroSAFE RARP or standard RARP. Men in the NeuroSAFE RARP arm will undergo RARP with NS guided by the NeuroSAFE technique. Men in the standard RARP arm will undergo RARP with NS guided by standard current practice (prostate cancer clinical characteristics, multi-parametric magnetic resonance imaging (mpMRI) recommendations and digital rectal examination (DRE)). Eligible men will have operable localised prostate cancer, will be opting for RARP as primary treatment and will have good baseline erectile function (EF) (as defined by an Internatinoal Index of Erectile Function (IIEF)-5 score >21). The primary outcome is the proportion of men who achieve EF recovery at 12-months according to the IIEF. Oncological safety will be ensured by the independent DMC who will routinely review proportions of men with treatment failure (adjuvant therapy or biochemical recurrence (BCR)) in each arm. A sample size of 404 is estimated required. NeuroSAFE PROOF will continue to follow participant recovery for 5 years following treatment. Key secondary outcomes include patient-reported urinary continence recovery, sexual satisfaction, quality of life, and economic analyses. NeuroSAFE PROOF will be the first RCT of frozen section in radical prostatectomy (RP) in the world. Ethics and dissemination: Ethical approval was obtained from the National Research Ethics Committee North London (17/LO/1978). Results of this study will be disseminated through national and international papers, and to study participants. Clinical trial information: NCT03317990.
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Nair-Shalliker, Visalini, David P. Smith, Val Gebski, Manish I. Patel, Mark Frydenberg, John W. Yaxley, Robert Gardiner et al. „High-dose vitamin D supplementation to prevent prostate cancer progression in localised cases with low-to-intermediate risk of progression on active surveillance (ProsD): protocol of a phase II randomised controlled trial“. BMJ Open 11, Nr. 3 (März 2021): e044055. http://dx.doi.org/10.1136/bmjopen-2020-044055.
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IntroductionActive surveillance (AS) for patients with prostate cancer (PC) with low risk of PC death is an alternative to radical treatment. A major drawback of AS is the uncertainty whether a patient truly has low risk PC based on biopsy alone. Multiparametric MRI scan together with biopsy, appears useful in separating patients who need curative therapy from those for whom AS may be safe. Two small clinical trials have shown short-term high-dose vitamin D supplementation may prevent PC progression. There is no substantial evidence for its long-term safety and efficacy, hence its use in the care of men with PC on AS needs assessment. This protocol describes the ProsD clinical trial which aims to determine if oral high-dose vitamin D supplementation taken monthly for 2 years can prevent PC progression in cases with low-to-intermediate risk of progression.Method and analysisThis is an Australian national multicentre, 2:1 double-blinded placebo-controlled phase II randomised controlled trial of monthly oral high-dose vitamin D supplementation (50 000 IU cholecalciferol), in men diagnosed with localised PC who have low-to-intermediate risk of disease progression and are being managed by AS. This trial will assess the feasibility, efficacy and safety of supplementing men with an initial oral loading dose of 500 000 IU cholecalciferol, followed by a monthly oral dose of 50 000 IU during the 24 months of AS. The primary trial outcome is the commencement of active therapy for clinical or non-clinical reason, within 2 years of AS.Ethics and disseminationThis trial is approved by Bellberry Ethics Committee (2016-06-459). All results will be reported in peer-reviewed journals.Trial registration numberACTRN12616001707459.
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Kim, Hyung-mok. „The Status of the National Debt Redemption Movement in Cheonan as the History of Regional Movements“. Yu Gwan sun Research Senter 28, Nr. 1 (30.06.2023): 67–112. http://dx.doi.org/10.56475/ygsrc.2023.28.1.67.
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Cheonan at the Late Period of Korean Empire was in an atmosphere of growing sense of crisis over colonization, including the Battle of Sesung Mountain, the Battle of Seonghwan, the development of Jiksan Gold Mine, and the construction of the Gyeongbu Rail. Meanwhile, foreign debt has snowballed, threatening the nation’s existence. The movement to protect national sovereignty by repaying foreign debts was felt everywhere.
Articles emphasizing the responsibilities and duties of the people were frequently reported in newspapers. The decisive factor that changed the situation was the national debt redemption movement based on ‘sharing and responsibility’. The signal fire started in Daegu, but immediately spread to Korea and abroad. Like other regions, Cheonan actively participated in this trend. Residents of Cheonan approached themself as if they were the main character.
Enlightenment officials issued a statement of intent and organized a national debt redemption movement committee to raise donations. This was the same as an important ‘stepping bridge’ that led to voluntary and competitive participation. Change came as a great stimulus to remind residents of their responsibilities as members of society. The various national movements here during the Korean Empire share this historical background.
The status of the National Debt Redemption Movement was part of paying back the national debt, but it greatly changed the values of the people of the time. Changes in perception to pursue ‘social publicity’ have made progress in line with this. The scene that awakened the importance of living together could be done in The status of the National Debt Redemption Movement. Isn’t the historical fact that was not limited to men and women of all ages despite their status a true spiritual legacy that must coexist in the Multicultural Era. In the end, peace and freedom, which are universal values of mankind, are essential factors such as responsibility and sacrifice.
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Asif, Aqua, Arjun Nathan, Alexander Ng, Pramit Khetrapal, Vinson Wai-Shun Chan, Francesco Giganti, Clare Allen et al. „Comparing biparametric to multiparametric MRI in the diagnosis of clinically significant prostate cancer in biopsy-naive men (PRIME): a prospective, international, multicentre, non-inferiority within-patient, diagnostic yield trial protocol“. BMJ Open 13, Nr. 4 (April 2023): e070280. http://dx.doi.org/10.1136/bmjopen-2022-070280.
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IntroductionProstate MRI is a well-established tool for the diagnostic work-up for men with suspected prostate cancer (PCa). Current recommendations advocate the use of multiparametric MRI (mpMRI), which is composed of three sequences: T2-weighted sequence (T2W), diffusion-weighted sequence (DWI) and dynamic contrast-enhanced sequence (DCE). Prior studies suggest that a biparametric MRI (bpMRI) approach, omitting the DCE sequences, may not compromise clinically significant cancer detection, though there are limitations to these studies, and it is not known how this may affect treatment eligibility. A bpMRI approach will reduce scanning time, may be more cost-effective and, at a population level, will allow more men to gain access to an MRI than an mpMRI approach.MethodsProstate Imaging Using MRI±Contrast Enhancement (PRIME) is a prospective, international, multicentre, within-patient diagnostic yield trial assessing whether bpMRI is non-inferior to mpMRI in the diagnosis of clinically significant PCa. Patients will undergo the full mpMRI scan. Radiologists will be blinded to the DCE and will initially report the MRI using only the bpMRI (T2W and DWI) sequences. They will then be unblinded to the DCE sequence and will then re-report the MRI using the mpMRI sequences (T2W, DWI and DCE). Men with suspicious lesions on either bpMRI or mpMRI will undergo prostate biopsy. The main inclusion criteria are men with suspected PCa, with a serum PSA of ≤20 ng/mL and without prior prostate biopsy. The primary outcome is the proportion of men with clinically significant PCa detected (Gleason score ≥3+4 or Gleason grade group ≥2). A sample size of at least 500 patients is required. Key secondary outcomes include the proportion of clinically insignificant PCa detected and treatment decision.Ethics and disseminationEthical approval was obtained from the National Research Ethics Committee West Midlands, Nottingham (21/WM/0091). Results of this trial will be disseminated through peer-reviewed publications. Participants and relevant patient support groups will be informed about the results of the trial.Trial registration numberNCT04571840.
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Newton, Robert U., Claus T. Christophersen, Ciaran M. Fairman, Nicolas H. Hart, Dennis R. Taaffe, David Broadhurst, Amanda Devine et al. „Does exercise impact gut microbiota composition in men receiving androgen deprivation therapy for prostate cancer? A single-blinded, two-armed, randomised controlled trial“. BMJ Open 9, Nr. 4 (April 2019): e024872. http://dx.doi.org/10.1136/bmjopen-2018-024872.
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IntroductionA potential link exists between prostate cancer (PCa) disease and treatment and increased inflammatory levels from gut dysbiosis. This study aims to examine if exercise favourably alters gut microbiota in men receiving androgen deprivation therapy (ADT) for PCa. Specifically, this study will explore whether: (1) exercise improves the composition of gut microbiota and increases the abundance of bacteria associated with health promotion and (2) whether gut health correlates with favourable inflammatory status, bowel function, continence and nausea among patients participating in the exercise intervention.Methods and analysisA single-blinded, two-armed, randomised controlled trial will explore the influence of a 3-month exercise programme (3 days/week) for men with high-risk localised PCa receiving ADT. Sixty patients will be randomly assigned to either exercise intervention or usual care. The primary endpoint (gut health and function assessed via feacal samples) and secondary endpoints (self-reported quality of life via standardised questionnaires, blood biomarkers, body composition and physical fitness) will be measured at baseline and following the intervention. A variety of statistical methods will be used to understand the covariance between microbial diversity and metabolomics profile across time and intervention. An intention-to-treat approach will be utilised for the analyses with multiple imputations followed by a secondary sensitivity analysis to ensure data robustness using a complete cases approach.Ethics and disseminationEthics approval was obtained from the Human Research Ethics Committee of Edith Cowan University (ID: 19827 NEWTON). Findings will be reported in peer-reviewed publications and scientific conferences in addition to working with national support groups to translate findings for the broader community. If exercise is shown to result in favourable changes in gut microbial diversity, composition and metabolic profile, and reduce gastrointestinal complications in PCa patients receiving ADT, this study will form the basis of a future phase III trial.Trial registration numberANZCTR12618000280202.
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Barbier, Charlotte Ebeling, Raquel Themudo, Tomas Bjerner, Lars Johansson, Bertil Lindahl, Per Venge, Lars Lind und Håkan Ahlström. „Cardiac Troponin I Associated with the Development of Unrecognized Myocardial Infarctions Detected with MRI“. Clinical Chemistry 60, Nr. 10 (01.10.2014): 1327–35. http://dx.doi.org/10.1373/clinchem.2014.222430.
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Abstract BACKGROUND Late enhancement MRI (LE-MRI) and cardiac troponin I (cTnI) are sensitive methods to detect subclinical myocardial injury. We sought to investigate the relation between plasma concentrations of cTnI measured with a high-sensitivity assay (hs-cTnI) and the development of unrecognized myocardial infarctions (UMIs) detected with LE-MRI. METHODS After approval from the ethics committee and written informed consent were obtained, LE-MRI was performed on 248 randomly selected community-living 70-year-old volunteers and hs-cTnI was determined with a highly sensitive premarket assay. Five years later these individuals were invited to a second LE-MRI, and 176 of them (82 women, 94 men), who did not have a hospital diagnosis of MI, constitute the present study population. LE-MR images were analyzed by 2 radiologists independently and in a consensus reading, blinded to any information on previous disease or assessments. RESULTS New or larger UMIs were detected in 37 participants during follow-up. Plasma concentrations of hs-cTnI at 70 years of age, which were mainly within what is considered to be the reference interval, were related to new or larger UMIs at 75 years of age with an odds ratio of 1.98 per 1 unit increase in ln-transformed cTnI (95% CI, 1.17–3.35; P = 0.010). Plasma concentrations of hs-cTnI at 70 years of age were associated with the volumes of the UMIs detected at 75 years of age (P = 0.028). CONCLUSIONS hs-cTnI in 70-year-old community-living women and men was associated with the development of MRI-detected UMIs within 5 years.
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Hasific, Selma, Kristian A. Øvrehus, Susanne Hosbond, Jess Lambrechtsen, Preman Kumarathurai, Anna Mejldal, Emil Johannes Ravn et al. „Effects of vitamins K2 and D3 supplementation in patients with severe coronary artery calcification: a study protocol for a randomised controlled trial“. BMJ Open 13, Nr. 7 (Juli 2023): e073233. http://dx.doi.org/10.1136/bmjopen-2023-073233.
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IntroductionCoronary artery calcification (CAC) and especially progression in CAC is a strong predictor of acute myocardial infarction and cardiovascular mortality. Supplementation with vitamin K2 and D3 has been suggested to have a protective role in the progression of CAC. In this study, we will examine the effect of vitamins K2 and D3 in men and women with severe CAC. We hypothesise that supplementation with vitamins K2 and D3 will slow down the calcification process.Method and analysisIn this multicentre and double-blinded placebo-controlled study, 400 men and women with CAC score≥400 are randomised (1:1) to treatment with vitamin K2 (720 µg/day) and vitamin D3 (25 µg/day) or placebo treatment (no active treatment) for 2 years. Among exclusion criteria are treatment with vitamin K antagonist, coagulation disorders and prior coronary artery disease. To evaluate progression in coronary plaque, a cardiac CT-scan is performed at baseline and repeated after 12 and 24 months of follow-up. Primary outcome is progression in CAC score from baseline to follow-up at 2 years. Among secondary outcomes are coronary plaque composition and cardiac events. Intention-to-treat principle is used for all analyses.Ethics and disseminationThere are so far no reported adverse effects associated with the use of vitamin K2. The protocol was approved by the Regional Scientific Ethical Committee for Southern Denmark and the Data Protection Agency. It will be conducted in accordance with the Declaration of Helsinki. Positive as well as negative findings will be reported.Trial registration numberNCT05500443.
Buchteile zum Thema "Committee for Men Blinded in Battle"
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Taplin, Oliver. „Vulnerable Places“. In Homeric Soundings, 203–50. Oxford University PressOxford, 1992. http://dx.doi.org/10.1093/oso/9780198140276.003.0008.
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Abstract But I am not to blame, but rather Zeus and Fate and Erinys that walks in darkness: they put a cruel blindness in my mind at the assembly on that day when by my own act I took away his prize from Achilleus. But what could I do? It is god who brings all things to their end. This blindness is Ate, eldest daughter of Zeus, the accursed goddess who blinds all men … So it has been for me in my case now. When great Hektor of the glinting helmet kept destroying the Argives by the sterns of the ships, I could not forget Ate and the blindness she brought on me on that first day. But since I was blinded and Zeus took away my wits, I am ready to take it back and offer the appeasement of limitless reparation. So rise now for battle, and rouse the rest of our people.