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Thematische Bibliographien / Circadian clock / Zeitschriftenartikel

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Zeitschriftenartikel zum Thema „Circadian clock“

Autor: Grafiati

Veröffentlicht am 4. Juni 2021

Zuletzt aktualisiert am 25. Juli 2025

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1

Xiao, Yangbo, Ye Yuan, Mariana Jimenez, Neeraj Soni, and Swathi Yadlapalli. "Clock proteins regulate spatiotemporal organization of clock genes to control circadian rhythms." Proceedings of the National Academy of Sciences 118, no. 28 (2021): e2019756118. http://dx.doi.org/10.1073/pnas.2019756118.

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Circadian clocks regulate ∼24-h oscillations in gene expression, behavior, and physiology. While the genetic and molecular mechanisms of circadian rhythms are well characterized, what remains poorly understood are the intracellular dynamics of circadian clock components and how they affect circadian rhythms. Here, we elucidate how spatiotemporal organization and dynamics of core clock proteins and genes affect circadian rhythms in Drosophila clock neurons. Using high-resolution imaging and DNA-fluorescence in situ hybridization techniques, we demonstrate that Drosophila clock proteins (PERIOD

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Costello, Hannah M., and Michelle L. Gumz. "Circadian Rhythm, Clock Genes, and Hypertension: Recent Advances in Hypertension." Hypertension 78, no. 5 (2021): 1185–96. http://dx.doi.org/10.1161/hypertensionaha.121.14519.

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Accumulating evidence suggests that the molecular circadian clock is crucial in blood pressure (BP) control. Circadian rhythms are controlled by the central clock, which resides in the suprachiasmatic nucleus of the hypothalamus and peripheral clocks throughout the body. Both light and food cues entrain these clocks but whether these cues are important for the circadian rhythm of BP is a growing area of interest. The peripheral clocks in the smooth muscle, perivascular adipose tissue, liver, adrenal gland, and kidney have been recently implicated in the regulation of BP rhythm. Dysregulation o

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Clark, Amelia M., and Brian J. Altman. "Circadian control of macrophages in the tumor microenvironment." Journal of Immunology 208, no. 1_Supplement (2022): 165.06. http://dx.doi.org/10.4049/jimmunol.208.supp.165.06.

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Abstract Introduction All leukocytes tested to date have functional circadian clocks, and nearly every arm of the immune response is subject to circadian regulation. Circadian clocks instruct the time-of-day-dependent, rhythmic expression of genes in a tissue- and cell-specific manner. In macrophages (mΦs), the circadian clock regulates several factors that are critical to executing effective immune responses. Tumor-associated mΦs are major contributors to immune suppression in the tumor microenvironment (TME). Evidence suggests that metabolically stressful factors in the TME such as acidic pH

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Shakhmantsir, Iryna, and Amita Sehgal. "Splicing the Clock to Maintain and Entrain Circadian Rhythms." Journal of Biological Rhythms 34, no. 6 (2019): 584–95. http://dx.doi.org/10.1177/0748730419868136.

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Circadian clocks drive daily rhythms of physiology and behavior in multiple organisms and synchronize these rhythms to environmental cycles of light and temperature. The basic mechanism of the clock consists of a transcription-translation feedback loop, in which key clock proteins negatively regulate their own transcription. Although much of the focus with respect to clock mechanisms has been on the regulation of transcription and on the stability and activity of clock proteins, it is clear that other regulatory processes also have to be involved to explain aspects of clock function. Here, we

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Myung, Jihwan, Mei-Yi Wu, Chun-Ya Lee, et al. "The Kidney Clock Contributes to Timekeeping by the Master Circadian Clock." International Journal of Molecular Sciences 20, no. 11 (2019): 2765. http://dx.doi.org/10.3390/ijms20112765.

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The kidney harbors one of the strongest circadian clocks in the body. Kidney failure has long been known to cause circadian sleep disturbances. Using an adenine-induced model of chronic kidney disease (CKD) in mice, we probe the possibility that such sleep disturbances originate from aberrant circadian rhythms in kidney. Under the CKD condition, mice developed unstable behavioral circadian rhythms. When observed in isolation in vitro, the pacing of the master clock, the suprachiasmatic nucleus (SCN), remained uncompromised, while the kidney clock became a less robust circadian oscillator with

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Fu, Minnie, and Xiaoyong Yang. "The sweet tooth of the circadian clock." Biochemical Society Transactions 45, no. 4 (2017): 871–84. http://dx.doi.org/10.1042/bst20160183.

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The endogenous circadian clock is a key regulator of daily metabolic processes. On the other hand, circadian clocks in a broad range of tissues can be tuned by extrinsic and intrinsic metabolic cues. The bidirectional interaction between circadian clocks and metabolism involves both transcriptional and post-translational mechanisms. Nuclear receptors exemplify the transcriptional programs that couple molecular clocks to metabolism. The post-translational modifications of the core clock machinery are known to play a key role in metabolic entrainment of circadian clocks. O-linked N-acetylglucosa

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Wu, Yiyang. "The Evolutionary Pathways of the Circadian Rhythms through Phylogenetical Analysis of Basal Circadian Genes." Highlights in Science, Engineering and Technology 54 (July 4, 2023): 367–76. http://dx.doi.org/10.54097/hset.v54i.9795.

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Circadian rhythm is the endogenous clock in organisms that regulates the performance of various physiological and metabolic events in accordance with the periodic oscillating changes in the environment, especially the periodic light-dark cycle. The clock has endowed organisms with the ability in anticipating environmental changes allowing them to adjust their survival strategies accordingly, promoting their selective fitness. However, the evolutionary path and the emergence of such an intricate and vital system remain elusive. The article aims to analyse the molecular architecture and componen

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Li, Meina, Lijun Cao, Musoki Mwimba, et al. "Comprehensive mapping of abiotic stress inputs into the soybean circadian clock." Proceedings of the National Academy of Sciences 116, no. 47 (2019): 23840–49. http://dx.doi.org/10.1073/pnas.1708508116.

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The plant circadian clock evolved to increase fitness by synchronizing physiological processes with environmental oscillations. Crop fitness was artificially selected through domestication and breeding, and the circadian clock was identified by both natural and artificial selections as a key to improved fitness. Despite progress in Arabidopsis, our understanding of the crop circadian clock is still limited, impeding its rational improvement for enhanced fitness. To unveil the interactions between the crop circadian clock and various environmental cues, we comprehensively mapped abiotic stress

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Bailey, Shannon M. "Emerging role of circadian clock disruption in alcohol-induced liver disease." American Journal of Physiology-Gastrointestinal and Liver Physiology 315, no. 3 (2018): G364—G373. http://dx.doi.org/10.1152/ajpgi.00010.2018.

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The detrimental health effects of excessive alcohol consumption are well documented. Alcohol-induced liver disease (ALD) is the leading cause of death from chronic alcohol use. As with many diseases, the etiology of ALD is influenced by how the liver responds to other secondary insults. The molecular circadian clock is an intrinsic cellular timing system that helps organisms adapt and synchronize metabolism to changes in their environment. The clock also influences how tissues respond to toxic, environmental, and metabolic stressors, like alcohol. Consistent with the essential role for clocks

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Helfrich-Förster, Charlotte, Michael N. Nitabach, and Todd C. Holmes. "Insect circadian clock outputs." Essays in Biochemistry 49 (June 30, 2011): 87–101. http://dx.doi.org/10.1042/bse0490087.

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Insects display an impressive variety of daily rhythms, which are most evident in their behaviour. Circadian timekeeping systems that generate these daily rhythms of physiology and behaviour all involve three interacting elements: the timekeeper itself (i.e. the clock), inputs to the clock through which it entrains and otherwise responds to environmental cues such as light and temperature, and outputs from the clock through which it imposes daily rhythms on various physiological and behavioural parameters. In insects, as in other animals, cellular clocks are embodied in clock neurons capable o

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Richards, Jacob, and Michelle L. Gumz. "Mechanism of the circadian clock in physiology." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 304, no. 12 (2013): R1053—R1064. http://dx.doi.org/10.1152/ajpregu.00066.2013.

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It has been well established that the circadian clock plays a crucial role in the regulation of almost every physiological process. It also plays a critical role in pathophysiological states including those of obesity and diabetes. Recent evidence has highlighted the potential for targeting the circadian clock as a potential drug target. New studies have also demonstrated the existence of “clock-independent effects” of the circadian proteins, leading to exciting new avenues of research in the circadian clock field in physiology. The goal of this review is to provide an introduction to and over

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Lu, Renbin, Yufan Dong, and Jia-Da Li. "Necdin regulates BMAL1 stability and circadian clock through SGT1-HSP90 chaperone machinery." Nucleic Acids Research 48, no. 14 (2020): 7944–57. http://dx.doi.org/10.1093/nar/gkaa601.

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Abstract Circadian clocks are endogenous oscillators that control ∼24-hour physiology and behaviors in virtually all organisms. The circadian oscillator comprises interconnected transcriptional and translational feedback loops, but also requires finely coordinated protein homeostasis including protein degradation and maturation. However, the mechanisms underlying the mammalian clock protein maturation is largely unknown. In this study, we demonstrate that necdin, one of the Prader-Willi syndrome (PWS)-causative genes, is highly expressed in the suprachiasmatic nuclei (SCN), the pacemaker of ci

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Amaral, Ian P. G., and Ian A. Johnston. "Circadian expression of clock and putative clock-controlled genes in skeletal muscle of the zebrafish." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 302, no. 1 (2012): R193—R206. http://dx.doi.org/10.1152/ajpregu.00367.2011.

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To identify circadian patterns of gene expression in skeletal muscle, adult male zebrafish were acclimated for 2 wk to a 12:12-h light-dark photoperiod and then exposed to continuous darkness for 86 h with ad libitum feeding. The increase in gut food content associated with the subjective light period was much diminished by the third cycle, enabling feeding and circadian rhythms to be distinguished. Expression of zebrafish paralogs of mammalian transcriptional activators of the circadian mechanism ( bmal1, clock1, and rora) followed a rhythmic pattern with a ∼24-h periodicity. Peak expression

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Manella, Gal, Rona Aviram, Nityanand Bolshette, et al. "Hypoxia induces a time- and tissue-specific response that elicits intertissue circadian clock misalignment." Proceedings of the National Academy of Sciences 117, no. 1 (2019): 779–86. http://dx.doi.org/10.1073/pnas.1914112117.

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The occurrence and sequelae of disorders that lead to hypoxic spells such as asthma, chronic obstructive pulmonary disease, and obstructive sleep apnea (OSA) exhibit daily variance. This prompted us to examine the interaction between the hypoxic response and the circadian clock in vivo. We found that the global transcriptional response to acute hypoxia is tissue-specific and time-of-day–dependent. In particular, clock components differentially responded at the transcriptional and posttranscriptional level, and these responses depended on an intact circadian clock. Importantly, exposure to hypo

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Harper, Ross E. F., Maite Ogueta, Peter Dayan, Ralf Stanewsky, and Joerg T. Albert. "Light Dominates Peripheral Circadian Oscillations in Drosophila melanogaster During Sensory Conflict." Journal of Biological Rhythms 32, no. 5 (2017): 423–32. http://dx.doi.org/10.1177/0748730417724250.

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In Drosophila, as in other animals, the circadian clock is a singular entity in name and concept only. In reality, clock functions emerge from multiple processes and anatomical substrates. One distinction has conventionally been made between a central clock (in the brain) and peripheral clocks (e.g., in the gut and the eyes). Both types of clock generate robust circadian oscillations, which do not require external input. Furthermore, the phases of these oscillations remain exquisitely sensitive to specific environmental cues, such as the daily changes of light and temperature. When these cues

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Durgan, David J., Margaret A. Hotze, Tara M. Tomlin, et al. "The intrinsic circadian clock within the cardiomyocyte." American Journal of Physiology-Heart and Circulatory Physiology 289, no. 4 (2005): H1530—H1541. http://dx.doi.org/10.1152/ajpheart.00406.2005.

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Circadian clocks are intracellular molecular mechanisms that allow the cell to anticipate the time of day. We have previously reported that the intact rat heart expresses the major components of the circadian clock, of which its rhythmic expression in vivo is consistent with the operation of a fully functional clock mechanism. The present study exposes oscillations of circadian clock genes [brain and arylhydrocarbon receptor nuclear translocator-like protein 1 ( bmal1), reverse strand of the c-erbaα gene ( rev-erbaα), period 2 ( per2), albumin D-element binding protein ( dbp)] for isolated adu

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Young, Martin E. "Anticipating anticipation: pursuing identification of cardiomyocyte circadian clock function." Journal of Applied Physiology 107, no. 4 (2009): 1339–47. http://dx.doi.org/10.1152/japplphysiol.00473.2009.

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Diurnal rhythms in myocardial physiology (e.g., metabolism, contractile function) and pathophyiology (e.g., sudden cardiac death) are well establish and have classically been ascribed to time-of-day-dependent alterations in the neurohumoral milieu. Existence of an intramyocellular circadian clock has recently been exposed. Circadian clocks enable the cell to anticipate environmental stimuli, facilitating a timely and appropriate response. Generation of genetically modified mice with a targeted disruption of the cardiomyocyte circadian clock has provided an initial means for deciphering the fun

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Zhang, Haoran, Zengxuan Zhou, and Jinhu Guo. "The Function, Regulation, and Mechanism of Protein Turnover in Circadian Systems in Neurospora and Other Species." International Journal of Molecular Sciences 25, no. 5 (2024): 2574. http://dx.doi.org/10.3390/ijms25052574.

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Circadian clocks drive a large array of physiological and behavioral activities. At the molecular level, circadian clocks are composed of positive and negative elements that form core oscillators generating the basic circadian rhythms. Over the course of the circadian period, circadian negative proteins undergo progressive hyperphosphorylation and eventually degrade, and their stability is finely controlled by complex post-translational pathways, including protein modifications, genetic codon preference, protein–protein interactions, chaperon-dependent conformation maintenance, degradation, et

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Lee, Kwangjun, Kwang-Seok Hong, Jonghoon Park, and Wonil Park. "Readjustment of circadian clocks by exercise intervention is a potential therapeutic target for sleep disorders: a narrative review." Physical Activity and Nutrition 28, no. 2 (2024): 35–42. http://dx.doi.org/10.20463/pan.2024.0014.

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[Purpose] Circadian clocks are evolved endogenous biological systems that communicate with environmental cues to optimize physiological processes, such as the sleep-wake cycle, which is nearly related to quality of life. Sleep disorders can be treated using pharmacological strategies targeting melatonin, orexin, or core clock genes. Exercise has been widely explored as a behavioral treatment because it challenges homeostasis in the human body and affects the regulation of core clock genes. Exercise intervention at the appropriate time of the day can induce a phase shift in internal clocks. Alt

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Challet, Etienne. "The circadian control of eating." Journal of Behavior and Feeding 1, no. 1 (2021): 39–50. http://dx.doi.org/10.32870/jbf.v1i1.14.

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Eating is a complex behavior that is primarily governed by energy homeostasis and modulated by hedonic cues. Eating is also structured in time, due to circadian clocks that control its daily rhythmicity. These circadian clocks are organized into a network of several oscillating structures, including a master clock in the suprachiasmatic nuclei of the hypothalamus and several secondary clocks in the brain and peripheral organs. The light-entrainable master clock is a conductor for the secondary clocks via neuroendocrine signals. In contrast to the master clock, most secondary clocks are sensiti

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Fuchikawa, T., K. Beer, C. Linke-Winnebeck, et al. "Neuronal circadian clock protein oscillations are similar in behaviourally rhythmic forager honeybees and in arrhythmic nurses." Open Biology 7, no. 6 (2017): 170047. http://dx.doi.org/10.1098/rsob.170047.

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Internal clocks driving rhythms of about a day (circadian) are ubiquitous in animals, allowing them to anticipate environmental changes. Genetic or environmental disturbances to circadian clocks or the rhythms they produce are commonly associated with illness, compromised performance or reduced survival. Nevertheless, some animals including Arctic mammals, open sea fish and social insects such as honeybees are active around-the-clock with no apparent ill effects. The mechanisms allowing this remarkable natural plasticity are unknown. We generated and validated a new and specific antibody again

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Charoensuksai, Purin, and Wei Xu. "PPARs in Rhythmic Metabolic Regulation and Implications in Health and Disease." PPAR Research 2010 (2010): 1–9. http://dx.doi.org/10.1155/2010/243643.

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The circadian rhythm, controlled by a complex network of cellular transcription factors, orchestrates behavior and physiology in the vast majority of animals. The circadian system is comprised of a master clock located in central nervous system with 24-hour rotation and periphery clocks to ensure optimal timing of physiology in peripheral tissues. Circadian expression of peroxisome proliferator-activated receptors (PPARs), members of the nuclear receptor superfamily and key mediators of energy homeostasis and metabolism, is regulated by clock genes. PPARs serve as sensors of nutrient and energ

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Patel, Sonal A., and Roman V. Kondratov. "Clock at the Core of Cancer Development." Biology 10, no. 2 (2021): 150. http://dx.doi.org/10.3390/biology10020150.

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To synchronize various biological processes with the day and night cycle, most organisms have developed circadian clocks. This evolutionarily conserved system is important in the temporal regulation of behavior, physiology and metabolism. Multiple pathological changes associated with circadian disruption support the importance of the clocks in mammals. Emerging links have revealed interplay between circadian clocks and signaling networks in cancer. Understanding the cross-talk between the circadian clock and tumorigenesis is imperative for its prevention, management and development of effectiv

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Wang, Xingwei, Yanfei Hu, and Wei Wang. "Comparative Analysis of Circadian Transcriptomes Reveals Circadian Characteristics between Arabidopsis and Soybean." Plants 12, no. 19 (2023): 3344. http://dx.doi.org/10.3390/plants12193344.

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The circadian clock, an endogenous timing system, exists in nearly all organisms on Earth. The plant circadian clock has been found to be intricately linked with various essential biological activities. Extensive studies of the plant circadian clock have yielded valuable applications. However, the distinctions of circadian clocks in two important plant species, Arabidopsis thaliana and Glycine max (soybean), remain largely unexplored. This study endeavors to address this gap by conducting a comprehensive comparison of the circadian transcriptome profiles of Arabidopsis and soybean to uncover t

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Margay, Adil Rahim, Suhail Ashraf, Nusrat Fatimah, et al. "Plant Circadian Clocks: Unravelling the Molecular Rhythms of Nature." International Journal of Plant & Soil Science 36, no. 8 (2024): 596–617. http://dx.doi.org/10.9734/ijpss/2024/v36i84890.

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The circadian clock is a fundamental biological mechanism that allows organisms to synchronize their internal processes with the external environment, thereby optimizing growth, development, and physiology. In plants, circadian rhythms govern various aspects of their life cycle, including germination, leaf movement, flowering, and responses to environmental cues such as light and temperature. Understanding the molecular mechanisms underlying plant circadian clocks is essential not only for elucidating fundamental principles of plant biology but also for applications in agriculture and biotechn

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Hirose, Misa, Alexei Leliavski, Leonardo Vinícius Monteiro de Assis, et al. "Chronic Inflammation Disrupts Circadian Rhythms in Splenic CD4+ and CD8+ T Cells in Mice." Cells 13, no. 2 (2024): 151. http://dx.doi.org/10.3390/cells13020151.

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Internal circadian clocks coordinate 24 h rhythms in behavior and physiology. Many immune functions show daily oscillations, and cellular circadian clocks can impact immune functions and disease outcome. Inflammation may disrupt circadian clocks in peripheral tissues and innate immune cells. However, it remains elusive if chronic inflammation impacts adaptive immune cell clock, e.g., in CD4+ and CD8+ T lymphocytes. We studied this in the experimental autoimmune encephalomyelitis (EAE), a mouse model for multiple sclerosis, as an established experimental paradigm for chronic inflammation. We an

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Kidd, Philip B., Michael W. Young, and Eric D. Siggia. "Temperature compensation and temperature sensation in the circadian clock." Proceedings of the National Academy of Sciences 112, no. 46 (2015): E6284—E6292. http://dx.doi.org/10.1073/pnas.1511215112.

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All known circadian clocks have an endogenous period that is remarkably insensitive to temperature, a property known as temperature compensation, while at the same time being readily entrained by a diurnal temperature oscillation. Although temperature compensation and entrainment are defining features of circadian clocks, their mechanisms remain poorly understood. Most models presume that multiple steps in the circadian cycle are temperature-dependent, thus facilitating temperature entrainment, but then insist that the effect of changes around the cycle sums to zero to enforce temperature comp

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Yari Kamrani, Yousef, Aida Shomali, Sasan Aliniaeifard, et al. "Regulatory Role of Circadian Clocks on ABA Production and Signaling, Stomatal Responses, and Water-Use Efficiency under Water-Deficit Conditions." Cells 11, no. 7 (2022): 1154. http://dx.doi.org/10.3390/cells11071154.

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Plants deploy molecular, physiological, and anatomical adaptations to cope with long-term water-deficit exposure, and some of these processes are controlled by circadian clocks. Circadian clocks are endogenous timekeepers that autonomously modulate biological systems over the course of the day–night cycle. Plants’ responses to water deficiency vary with the time of the day. Opening and closing of stomata, which control water loss from plants, have diurnal responses based on the humidity level in the rhizosphere and the air surrounding the leaves. Abscisic acid (ABA), the main phytohormone modu

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Beaulé, Christian, and Hai-Ying M. Cheng. "The Acetyltransferase CLOCK Is Dispensable for Circadian Aftereffects in Mice." Journal of Biological Rhythms 26, no. 6 (2011): 561–64. http://dx.doi.org/10.1177/0748730411416329.

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Recent demonstration of the histone acetyltransferase activity of the Clock gene greatly expanded the regulatory role of circadian clocks in gene transcription. Clock and its partner Bmal1 are responsible for the generation of circadian oscillations that are synchronized (entrained) to the external light cycle. Entraining light often produces long-lasting changes in the endogenous period called aftereffects. Aftereffects are light-dependent alterations in the speed of free-running rhythms that persist for several weeks upon termination of light exposure. How light causes such long-lasting chan

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Ruqiya Pervaiz. "CIRCADIAN IMMUNITY AND COVID-19: UNVEILING THE SIRT1 CONNECTION." Kashf Journal of Multidisciplinary Research 2, no. 06 (2025): 25–31. https://doi.org/10.71146/kjmr492.

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Background: Immunity against infectious diseases, particularly viral infections where antibiotics do not work, plays a key role in their eradication. Therefore, it is essential to identify the natural and biological factors that contribute to a strong immune response to combat COVID-19 and other diseases effectively. Methodology: In this study, we investigated the relationship between the circadian clock, immune function, and the eradication of COVID-19. Also, we evaluate the past research works for the analysis. Results: In this analysis, we examine how SIRT1, circadian clocks, and COVID-19 i

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James, Allan B., José A. Monreal, Gillian A. Nimmo, et al. "The Circadian Clock inArabidopsisRoots Is a Simplified Slave Version of the Clock in Shoots." Science 322, no. 5909 (2008): 1832–35. http://dx.doi.org/10.1126/science.1161403.

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The circadian oscillator in eukaryotes consists of several interlocking feedback loops through which the expression of clock genes is controlled. It is generally assumed that all plant cells contain essentially identical and cell-autonomous multiloop clocks. Here, we show that the circadian clock in the roots of matureArabidopsisplants differs markedly from that in the shoots and that the root clock is synchronized by a photosynthesis-related signal from the shoot. Two of the feedback loops of the plant circadian clock are disengaged in roots, because two key clock components, the transcriptio

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Eelderink-Chen, Zheng, Gabriella Mazzotta, Marcel Sturre, Jasper Bosman, Till Roenneberg, and Martha Merrow. "A circadian clock in Saccharomyces cerevisiae." Proceedings of the National Academy of Sciences 107, no. 5 (2010): 2043–47. http://dx.doi.org/10.1073/pnas.0907902107.

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Circadian timing is a fundamental biological process, underlying cellular physiology in animals, plants, fungi, and cyanobacteria. Circadian clocks organize gene expression, metabolism, and behavior such that they occur at specific times of day. The biological clocks that orchestrate these daily changes confer a survival advantage and dominate daily behavior, for example, waking us in the morning and helping us to sleep at night. The molecular mechanism of circadian clocks has been sketched out in genetic model systems from prokaryotes to humans, revealing a combination of transcriptional and

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Ma, Qianwen, Genlin Mo, and Yong Tan. "Micro RNAs and the biological clock: a target for diseases associated with a loss of circadian regulation." African Health Sciences 20, no. 4 (2020): 1887–94. http://dx.doi.org/10.4314/ahs.v20i4.46.

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Background: Circadian clocks are self-sustaining oscillators that coordinate behavior and physiology over a 24 hour peri- od, achieving time-dependent homeostasis with the external environment. The molecular clocks driving circadian rhythmic changes are based on intertwined transcriptional/translational feedback loops that combine with a range of environmental and metabolic stimuli to generate daily internal programing. Understanding how biological rhythms are generated through- out the body and the reasons for their dysregulation can provide avenues for temporally directed therapeutics. Summa

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Vlachou, Denise, Maria Veretennikova, Laura Usselmann, et al. "TimeTeller: A tool to probe the circadian clock as a multigene dynamical system." PLOS Computational Biology 20, no. 2 (2024): e1011779. http://dx.doi.org/10.1371/journal.pcbi.1011779.

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Recent studies have established that the circadian clock influences onset, progression and therapeutic outcomes in a number of diseases including cancer and heart diseases. Therefore, there is a need for tools to measure the functional state of the molecular circadian clock and its downstream targets in patients. Moreover, the clock is a multi-dimensional stochastic oscillator and there are few tools for analysing it as a noisy multigene dynamical system. In this paper we consider the methodology behind TimeTeller, a machine learning tool that analyses the clock as a noisy multigene dynamical

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Singh, Amit, Congxin Li, Axel C. R. Diernfellner, Thomas Höfer, and Michael Brunner. "Data-driven modelling captures dynamics of the circadian clock of Neurospora crassa." PLOS Computational Biology 18, no. 8 (2022): e1010331. http://dx.doi.org/10.1371/journal.pcbi.1010331.

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Eukaryotic circadian clocks are based on self-sustaining, cell-autonomous oscillatory feedback loops that can synchronize with the environment via recurrent stimuli (zeitgebers) such as light. The components of biological clocks and their network interactions are becoming increasingly known, calling for a quantitative understanding of their role for clock function. However, the development of data-driven mathematical clock models has remained limited by the lack of sufficiently accurate data. Here we present a comprehensive model of the circadian clock of Neurospora crassa that describe free-r

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Cruz, Leo Nava Piorsky Dominici, Rayane Teles-de-Freitas, Maria Eduarda Barreto Resck, et al. "Light and dark cycles modify the expression of clock genes in the ovaries of Aedes aegypti in a noncircadian manner." PLOS ONE 18, no. 10 (2023): e0287237. http://dx.doi.org/10.1371/journal.pone.0287237.

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Circadian oscillators (i.e., circadian clocks) are essential to producing the circadian rhythms observed in virtually all multicellular organisms. In arthropods, many rhythmic behaviors are generated by oscillations of the central pacemaker, specific groups of neurons of the protocerebrum in which the circadian oscillator molecular machinery is expressed and works; however, oscillators located in other tissues (i.e., peripheral clocks) could also contribute to certain rhythms, but are not well known in non-model organisms. Here, we investigated whether eight clock genes that likely constitute

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Tian, Wenwen, Ruyi Wang, Cunpei Bo, et al. "SDC mediates DNA methylation-controlled clock pace by interacting with ZTL in Arabidopsis." Nucleic Acids Research 49, no. 7 (2021): 3764–80. http://dx.doi.org/10.1093/nar/gkab128.

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Abstract Molecular bases of eukaryotic circadian clocks mainly rely on transcriptional-translational feedback loops (TTFLs), while epigenetic codes also play critical roles in fine-tuning circadian rhythms. However, unlike histone modification codes that play extensive and well-known roles in the regulation of circadian clocks, whether DNA methylation (5mC) can affect the circadian clock, and the associated underlying molecular mechanisms, remains largely unexplored in many organisms. Here we demonstrate that global genome DNA hypomethylation can significantly lengthen the circadian period of

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Froy, Oren. "The circadian clock and metabolism." Clinical Science 120, no. 2 (2010): 65–72. http://dx.doi.org/10.1042/cs20100327.

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Mammals have developed an endogenous circadian clock located in the SCN (suprachiasmatic nuclei) of the anterior hypothalamus that responds to the environmental light–dark cycle. Human homoeostatic systems have adapted to daily changes in a way that the body anticipates the sleep and activity periods. Similar clocks have been found in peripheral tissues, such as the liver, intestine and adipose tissue. Recently it has been found that the circadian clock regulates cellular and physiological functions in addition to the expression and/or activity of enzymes and hormones involved in metabolism. I

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de Assis, Leonardo Vinícius Monteiro, and Henrik Oster. "The circadian clock and metabolic homeostasis: entangled networks." Cellular and Molecular Life Sciences 78, no. 10 (2021): 4563–87. http://dx.doi.org/10.1007/s00018-021-03800-2.

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AbstractThe circadian clock exerts an important role in systemic homeostasis as it acts a keeper of time for the organism. The synchrony between the daily challenges imposed by the environment needs to be aligned with biological processes and with the internal circadian clock. In this review, it is provided an in-depth view of the molecular functioning of the circadian molecular clock, how this system is organized, and how central and peripheral clocks communicate with each other. In this sense, we provide an overview of the neuro-hormonal factors controlled by the central clock and how they a

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Fletcher, Elizabeth K., Monica Kanki, James Morgan, et al. "Cardiomyocyte transcription is controlled by combined mineralocorticoid receptor and circadian clock signalling." Journal of Endocrinology 241, no. 1 (2019): 17–29. http://dx.doi.org/10.1530/joe-18-0584.

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We previously identified a critical pathogenic role for mineralocorticoid receptor (MR) activation in cardiomyocytes that included a potential interaction between the MR and the molecular circadian clock. While glucocorticoid regulation of the circadian clock is undisputed, studies on MR interactions with circadian clock signalling are limited. We hypothesised that the MR influences cardiac circadian clock signalling, and vice versa. Aldosterone or corticosterone (10 nM) regulated Cry1, Per1, Per2 and ReverbA (Nr1d1) gene expression patterns in H9c2 cells over 24 h. MR-dependent regulation of

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McWatters, Harriet G., Laura C. Roden, and Dorothee Staiger. "Picking out parallels: plant circadian clocks in context." Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 356, no. 1415 (2001): 1735–43. http://dx.doi.org/10.1098/rstb.2001.0936.

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Molecular models have been described for the circadian clocks of representatives of several different taxa. Much of the work on the plant circadian system has been carried out using the thale cress, Arabidopsis thaliana , as a model. We discuss the roles of genes implicated in the plant circadian system, with special emphasis on Arabidopsis . Plants have an endogenous clock that regulates many aspects of circadian and photoperiodic behaviour. Despite the discovery of components that resemble those involved in the clocks of animals or fungi, no coherent model of the plant clock has yet been pro

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Sharma, Ashish, Gautam Sethi, Murtaza M. Tambuwala, et al. "Circadian Rhythm Disruption and Alzheimer’s Disease: The Dynamics of a Vicious Cycle." Current Neuropharmacology 19, no. 2 (2020): 248–64. http://dx.doi.org/10.2174/1570159x18666200429013041.

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: All mammalian cells exhibit circadian rhythm in cellular metabolism and energetics. Autonomous cellular clocks are modulated by various pathways that are essential for robust time keeping. In addition to the canonical transcriptional translational feedback loop, several new pathways of circadian timekeeping - non-transcriptional oscillations, post-translational modifications, epigenetics and cellular signaling in the circadian clock - have been identified. The physiology of circadian rhythm is expansive, and its link to the neurodegeneration is multifactorial. Circadian rhythm disruption is

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Erisa, Kungu. "Immunomodulation through the Circadian Clock: Impacts on Inflammation and Immunity." NEWPORT INTERNATIONAL JOURNAL OF PUBLIC HEALTH AND PHARMACY 5, no. 3 (2024): 43–47. http://dx.doi.org/10.59298/nijpp/2024/5343470.

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The circadian clock, an intrinsic timekeeping system regulating physiological functions over a 24-hour cycle, profoundly influences immune responses and inflammation. Immune cells, including neutrophils, macrophages, and lymphocytes, exhibit circadian rhythms in their numbers, function, and migration. These rhythms are regulated by both central and peripheral clocks, synchronizing immune cell activity with environmental cues. The circadian clock modulates key immune processes such as leukocyte trafficking, cytokine production, and phagocytosis, affecting the body’s ability to respond to pathog

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Oosterman, Johanneke E., Andries Kalsbeek, Susanne E. la Fleur, and Denise D. Belsham. "Impact of nutrients on circadian rhythmicity." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 308, no. 5 (2015): R337—R350. http://dx.doi.org/10.1152/ajpregu.00322.2014.

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The suprachiasmatic nucleus (SCN) in the mammalian hypothalamus functions as an endogenous pacemaker that generates and maintains circadian rhythms throughout the body. Next to this central clock, peripheral oscillators exist in almost all mammalian tissues. Whereas the SCN is mainly entrained to the environment by light, peripheral clocks are entrained by various factors, of which feeding/fasting is the most important. Desynchronization between the central and peripheral clocks by, for instance, altered timing of food intake can lead to uncoupling of peripheral clocks from the central pacemak

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Leloup, Jean-Christophe. "Circadian clocks and phosphorylation: Insights from computational modeling." Open Life Sciences 4, no. 3 (2009): 290–303. http://dx.doi.org/10.2478/s11535-009-0025-1.

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AbstractCircadian clocks are based on a molecular mechanism regulated at the transcriptional, translational and post-translational levels. Recent experimental data unravel a complex role of the phosphorylations in these clocks. In mammals, several kinases play differential roles in the regulation of circadian rhythmicity. A dysfunction in the phosphorylation of one clock protein could lead to sleep disorders such as the Familial Advanced Sleep Phase Disorder, FASPS. Moreover, several drugs are targeting kinases of the circadian clocks and can be used in cancer chronotherapy or to treat mood di

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Uehara, Takahiro N., Yoshiyuki Mizutani, Keiko Kuwata, et al. "Casein kinase 1 family regulates PRR5 and TOC1 in the Arabidopsis circadian clock." Proceedings of the National Academy of Sciences 116, no. 23 (2019): 11528–36. http://dx.doi.org/10.1073/pnas.1903357116.

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The circadian clock provides organisms with the ability to adapt to daily and seasonal cycles. Eukaryotic clocks mostly rely on lineage-specific transcriptional-translational feedback loops (TTFLs). Posttranslational modifications are also crucial for clock functions in fungi and animals, but the posttranslational modifications that affect the plant clock are less understood. Here, using chemical biology strategies, we show that the Arabidopsis CASEIN KINASE 1 LIKE (CKL) family is involved in posttranslational modification in the plant clock. Chemical screening demonstrated that an animal CDC7

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Johnson, C. H., Y. Nakaoka, and I. Miwa. "The effects of altering extracellular potassium ion concentration on the membrane potential and circadian clock of Paramecium bursaria." Journal of Experimental Biology 197, no. 1 (1994): 295–308. http://dx.doi.org/10.1242/jeb.197.1.295.

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In some neural models of circadian rhythmicity, membrane potential and transmembrane flux of potassium and calcium ions appear to play important roles in the entrainment and central mechanisms of the biological clock. We wondered whether these cellular variables might be generally involved in circadian clocks, even non-neural clocks. Therefore, we tested the impact of changing extracellular potassium level on the circadian rhythm of photoaccumulation of Paramecium cells, whose membrane potential responds to changes of extracellular potassium in a manner similar to that of neurones. We found th

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An, Zheming, Benedetto Piccoli, Martha Merrow, and Kwangwon Lee. "A Unified Model for Entrainment by Circadian Clocks: Dynamic Circadian Integrated Response Characteristic (dCiRC)." Journal of Biological Rhythms 37, no. 2 (2022): 202–15. http://dx.doi.org/10.1177/07487304211069454.

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Circadian rhythms are ubiquitous and are observed in all biological kingdoms. In nature, their primary characteristic or phenotype is the phase of entrainment. There are two main hypotheses related to how circadian clocks entrain, parametric and non-parametric models. The parametric model focuses on the gradual changes of the clock parameters in response to the changing ambient condition, whereas the non-parametric model focuses on the instantaneous change of the phase of the clock in response to the zeitgeber. There are ample empirical data supporting both models. However, only recently has a

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Ahmad, Myra, Wanhe Li, and Deniz Top. "Integration of Circadian Clock Information in the Drosophila Circadian Neuronal Network." Journal of Biological Rhythms 36, no. 3 (2021): 203–20. http://dx.doi.org/10.1177/0748730421993953.

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Circadian clocks are biochemical time-keeping machines that synchronize animal behavior and physiology with planetary rhythms. In Drosophila, the core components of the clock comprise a transcription/translation feedback loop and are expressed in seven neuronal clusters in the brain. Although it is increasingly evident that the clocks in each of the neuronal clusters are regulated differently, how these clocks communicate with each other across the circadian neuronal network is less clear. Here, we review the latest evidence that describes the physical connectivity of the circadian neuronal ne

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Franco, D. Lorena, Lia Frenkel, and M. Fernanda Ceriani. "The Underlying Genetics of Drosophila Circadian Behaviors." Physiology 33, no. 1 (2018): 50–62. http://dx.doi.org/10.1152/physiol.00020.2017.

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Life is shaped by circadian clocks. This review focuses on how behavioral genetics in the fruit fly unveiled what is known today about circadian physiology. We will briefly summarize basic properties of the clock and focus on some clock-controlled behaviors to highlight how communication between central and peripheral oscillators defines their properties.

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