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1

Yuliu Chen und M. M. Tseng. „A stair-like CIM system architecture“. IEEE Transactions on Components, Packaging, and Manufacturing Technology: Part C 20, Nr. 2 (April 1997): 101–10. http://dx.doi.org/10.1109/3476.622880.

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2

H, Jayalaxmi, und S. Ramachandran. „Performance analysis on color image mosaicing techniques on FPGA“. International Journal of Electrical and Computer Engineering (IJECE) 9, Nr. 3 (01.06.2019): 1630. http://dx.doi.org/10.11591/ijece.v9i3.pp1630-1636.

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Today, the surveillance systems and other monitoring systems are considering the capturing of image sequences in a single frame. The captured images can be combined to get the mosaiced image or combined image sequence. But the captured image may have quality issues like brightness issue, alignment issue (correlation issue), resolution issue, manual image registration issue etc. The existing technique like cross correlation can offer better image mosaicing but faces brightness issue in mosaicing. Thus, this paper introduces two different methods for mosaicing i.e., (a) Sliding Window Module (SWM) based Color Image Mosaicing (CIM) and (b) Discrete Cosine Transform (DCT) based CIM on Field Programmable Gate Array (FPGA). The SWM based CIM adopted for corner detection of two images and perform the automatic image registration while DCT based CIM aligns both the local as well as global alignment of images by using phase correlation approach. Finally, these two methods performances are analyzed by comparing with parameters like PSNR, MSE, device utilization and execution time. From the analysis it is concluded that the DCT based CIM can offers significant results than SWM based CIM.
3

Chen, Chen, und Song Jiang Wang. „Analysis of Hydropower Project Financing Risk TOT Mode Using the CIM – AHP Mode — Nansha Hydropower Station in Yunnan as an Example“. Advanced Materials Research 468-471 (Februar 2012): 260–67. http://dx.doi.org/10.4028/www.scientific.net/amr.468-471.260.

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TOT as a new project financing mode, its appearance effectively solves problems like the lack of government investment funds, management inefficiency and others. But because of its complex organizational structure involving more than one principal, the potential risk is enormous. In this paper, I use AHP method to conduct comprehensive and systematic risk identification for TOT projects and establish the control interval and memory (CIM) model to assess the risks of hydropower financing. The application of CIM in engineering practice shows the effectiveness and feasibility of CIM, the comprehensive evaluation method in the risk assessment.
4

Kamiya, M., S. U. Kim, J. Y. Kim, Y. W. Song, E. Y. Lee und F. Mizoguchi. „SAT0295 GLUCAGON-LIKE PEPTIDE-1 RECEPTOR AGONIST AMELIORATED MUSCLE WEAKNESS AND INFLAMMATION IN EXPERIMENTAL POLYMYOSITIS“. Annals of the Rheumatic Diseases 79, Suppl 1 (Juni 2020): 1092–93. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1597.

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Background:Polymyositis (PM) is a chronic inflammatory myopathy that impairs muscle functions. While the treatment with glucocorticoids (GC) has been the cornerstone of the treatment for PM to suppress immune-mediated muscle injury, some patients suffer from glucocorticoid-induced myopathy during the treatment, which further deteriorates the muscle weakness. It has been reported that significant disability and muscle weakness persist in a quarter of the patients even after successful treatment with the immunosuppressive therapy1. Ultimately, new therapeutic strategies to preserve and recover muscle strength as well as to suppress immune-mediated muscle injury are needed. Glucagon-like peptide-1 (GLP-1) is a peptide hormone with a variety of functions. Although GLP-1 receptor (GLP-1R) agonists have been developed as an anti-diabetic therapy to promote insulin secretion, emerging data suggest that they have pleiotropic actions including anti-inflammatory effects and suppression of muscle wasting2. We presumed that GLP-1R agonists have beneficial effect on PM to preserve and recover muscle strength.Objectives:To examine the effect of a GLP-1R agonist on C protein-induced myositis (CIM), a murine model of polymyositis3, in monotherapy or in combination with prednisolone (PSL).Methods:Muscle specimens of PM patients and CIM were examined with immunohistological staining for the expression of GLP-1R. The therapeutic effect of PF1801 (ImmunoForge), a GLP-1R agonist (5 mg/kg body weight (BW)/day), in monotherapy or in combination with PSL (20 mg/kg BW/day) on CIM was examined for grip strength, muscle weight and histological muscle inflammation.Results:GLP-1R was expressed on the plasma membrane of muscle cells of PM patients and CIM. The expression levels were high in the area where inflammatory infiltrates were observed. The treatment of CIM with PF1801 in monotherapy or in combination with PSL suppressed the CIM-induced decrease in grip strength on day 14. The combination therapy with PF1801 and PSL ameliorated the CIM-induced muscle weight loss in quadriceps, while the monotherapy with PF1801 or PSL did not. The histological analysis of muscle specimens on day 14 of CIM revealed that the muscle inflammation was suppressed by the treatments with PF1801, PSL, or the combination of PF1801 and PSL. None of the mice in the combination therapy group developed histologically evident myositis, while the myositis was observed in 90%, 40% and 40 % of the mice in vehicle treated group, PF1801 treated group, and PSL treated group, respectively. The necrotic area of the muscle in CIM was also reduced in the mice treated with PF1801, PSL, or the combination of PSL and PF1801. The CIM-induced increase in spleen weight was suppressed by PF1801, PSL, or the combination of PSL and PF1801. The additive effect of PSL and PF1801 on the suppression of CIM-induced increase in spleen weight was observed.Conclusion:PF1801 ameliorated CIM-induced muscle weakness and muscle inflammation in CIM. The combination therapy with PF1801 and PSL ameliorated CIM-induced muscle weight loss. PF1801 could be a novel therapy to recover muscle weakness and to suppress muscle inflammation in PM.References:[1]Bronner IM, et al.Ann Rheum Dis.2006;65:1456–61.[2]Hong Y, et al.J Cachexia Sarcopenia Muscle. 2019;10:903-18.[3]Sugihara T, et al.Arthritis Rheum. 2007;56:1304-14.Disclosure of Interests:Mari Kamiya: None declared, Seon Uk Kim: None declared, Jeong Yeon Kim: None declared, Yeong Wook Song: None declared, Eun Young Lee: None declared, Fumitaka Mizoguchi Grant/research support from: ImmunoForge, Consultant of: ImmunoForge
5

Riazi, Negin A., Sébastien Blanchette, François Trudeau, Richard Larouche, Mark S. Tremblay und Guy Faulkner. „Correlates of Children’s Independent Mobility in Canada: A Multi-Site Study“. International Journal of Environmental Research and Public Health 16, Nr. 16 (10.08.2019): 2862. http://dx.doi.org/10.3390/ijerph16162862.

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Globally, physical inactivity is a concern, and children’s independent mobility (CIM) may be an important target behavior for addressing the physical inactivity crisis. The aim of this study was to examine correlates of CIM (8–12 years old) in the Canadian context to inform future interventions. CIM was measured via parent surveys. Individual, social, and environmental correlates of CIM were examined using a social–ecological framework. 1699 participants’ data were analyzed using descriptive statistics and gender-stratified linear mixed-effects models while controlling for site, area-level socioeconomic status, and type of urbanization. Individual correlates including child grade (β = 0.612, p < 0.001), language spoken at home (β = −0.503, p < 0.001), car ownership (β = −0.374, p < 0.05), and phone ownership (β = 0.593, p < 0.001) were associated with CIM. For boys, parental gender (β = −0.387, p < 0.01) was negatively associated with CIM. Parents’ perceptions of safety and environment were significantly associated with CIM. Location (i.e., site) was significantly associated with CIM (ref: Trois-Rivières; Ottawa (β = −1.188, p < 0.001); Vancouver (β = −1.216, p < 0.001)). Suburban environments were negatively associated with boys’ independent mobility (β = −0.536, p < 0.05), while walkability (400 m β = 0.064, p < 0.05; 1600 m β = −0.059, p < 0.05) was significantly associated with girls’ independent mobility only. Future research and interventions should consider targeting “modifiable factors” like children’s and parents’ perceptions of neighborhood safety and environment.
6

Sangild, Per T., René Liang Shen, Peter Pontoppidan und Mathias Rathe. „Animal models of chemotherapy-induced mucositis: translational relevance and challenges“. American Journal of Physiology-Gastrointestinal and Liver Physiology 314, Nr. 2 (01.02.2018): G231—G246. http://dx.doi.org/10.1152/ajpgi.00204.2017.

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Chemotherapy for cancer patients induces damaging tissue reactions along the epithelium of the gastrointestinal tract (GIT). This chemotherapy-induced mucositis (CIM) is a serious side effect of cytotoxic drugs, and several animal models of CIM have been developed, mainly in rodents and piglets, to help understand the progression of CIM and how to prevent it. Animal models allow highly controlled experimental conditions, detailed organ (e.g., GIT) insights, standardized, clinically relevant treatment regimens, and discovery of new biomarkers. Still, surprisingly few results from animal models have been translated into clinical CIM management and treatments. The results obtained from specific animal models can be difficult to translate to the diverse range of CIM manifestations in patients, which vary according to the antineoplastic drugs, dose, underlying (cancer) disease, and patient characteristics (e.g., age, genetics, and body constitution). Another factor that hinders the direct use of results from animals is inadequate collaboration between basic science and clinical science in relation to CIM. Here, we briefly describe CIM pathophysiology, particularly the basic knowledge that has been obtained from CIM animal models. These model studies have indicated potential new preventive and ameliorating interventions, including supplementation with natural bioactive diets (e.g., milk fractions, colostrum, and plant extracts), nutrients (e.g., polyunsaturated fatty acids, short-chain fatty acids, and glutamine), and growth factor peptides (e.g., transforming growth factor and glucagon-like peptide-2), as well as manipulations of the gut microbiota (e.g., prebiotics, probiotics, and antibiotics). Rodent CIM models allow well-controlled, in-depth studies of animals with or without tumors while pig models more easily make clinically relevant treatment regimens possible. In synergy, animal models of CIM provide the basic physiological understanding and the new ideas for treatment that are required to make competent decisions in clinical practice.
7

Fei, Kailun, Yundi Zhang, Yiting Dong, Liman Liman, Yiqi Li, Wenjing Yang, Jie Wang und Zhijie Wang. „Real-world burden and treatments of chemotherapy-induced myelosuppression among patients with extensive-stage small-cell lung cancer: A retrospective real-world study in China.“ Journal of Clinical Oncology 42, Nr. 16_suppl (01.06.2024): e20102-e20102. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e20102.

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e20102 Background: Chemotherapy-induced myelosuppression (CIM) is the major dose-limiting and severe complication for chemotherapy, particularly etoposide plus platinum-based therapy (EP), in patients with extensive-stage small-cell lung cancer (ES-SCLC). CIM adversely affects patient quality of life and imposes substantial economic burden. In China, there’s a scarcity of related studies, especially in large cohort. This study aims to summarize the burden and treatments of CIM in ES-SCLC patients using a nationally representative real-world database. Methods: Data were derived from 53 hospitals across 28 provinces, as part of the National Cancer Center (NCC) database. ES-SCLC patients receiving EP between 2018.1.1 and 2022.12.31 were included. CIM events, namely chemotherapy induced neutropenia (CIN), thrombocytopenia (CIT), and anemia (CRA) were identified based on laboratory tests and graded according to Common Terminology Criteria for Adverse Events (CTCAE) version 5. Incidence, treatments and impact on hospitalization cost of CIM were described. Results: 7,505 patients were included, with an average age of 61.2 years (SD = 9.02) and an average of 5.0 chemotherapy cycles (SD = 2.01). The overall incidence of CIM was 91.95%, with grade 3-4 CIM occurring in 25.09% patients. Incidence of CIN, CIT, and CRA, were 44.74%, 39.20%, and 86.48%, respectively, with febrile neutropenia at 0.72%. Among patients with CIN, 90.89% patients used granulocyte colony stimulating factor (G-CSF), and 90.56% used it prophylactically. Among patients with CIT, 17.47% used recombinant human thrombopoietin (rhTPO) and 25.49% used recombinant human interleukin-11 (rhIL-11). Among patients with CRA, 10.26% used erythropoiesis-stimulating agent (ESA). Occurrence of grade 1-2 CIM and grade 3-4 CIM may increase 9.37% and 32.36% hospitalization cost per chemotherapy cycle, respectively (¥23,316.3 vs ¥21,318.2, ¥28,217.0 vs ¥21,318.2), compared to patients without any CIM. Conclusions: Incidence of CIM is notably high among ES-SCLC patients receiving EP, and treatments like G-CSF, rhTPO, rhIL-11 and ESA are widely used. Occurrence of CIM critically escalates hospitalization cost. Innovations to protect bone marrow from chemotherapy-induced damage are promising to alleviate the burden and benefit quality of life for ES-SCLC patients.[Table: see text]
8

La Russa, F. M., E. Grilli, F. Remondino, C. Santagati und M. Intelisano. „ADVANCED 3D PARAMETRIC HISTORIC CITY BLOCK MODELING COMBINING 3D SURVEYING, AI AND VPL“. International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLVIII-M-2-2023 (24.06.2023): 903–10. http://dx.doi.org/10.5194/isprs-archives-xlviii-m-2-2023-903-2023.

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Abstract. The presented research aims to define a parametric modelling methodology that allows, in short time and at a sustainable cost, the digital acquisition, modelling and semantic structuring of urban city blocks to facilitate 3D city modelling applied to historic centres. The methodology is based on field surveying and derives 3D data for the realisation of a parametric City Information Model (CIM). This is pursued through the adoption of parametric modelling as main method combined with AI procedures like supervised machine learning. In particular, the Visual Programming Language (VPL) Grasshopper is adopted as main working environment. The methodology proposed, called Scan-to-CIM, is developed to automate the cognitive operations of interpretation and input of surveying data performed in the field in order to create LoD4 city block models in a semi-automatic way. The proposed Scan-to-CIM methodology is applied to a city block located in the historic centre of Catania, Italy.
9

Deng, Gao-Ming, und Yong-Chang Huang. „Q − Φ criticality and microstructure of charged AdS black holes in f(R) gravity“. International Journal of Modern Physics A 32, Nr. 35 (20.12.2017): 1750204. http://dx.doi.org/10.1142/s0217751x17502049.

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The phase transition and critical behaviors of charged AdS black holes in [Formula: see text] gravity with a conformally invariant Maxwell (CIM) source and constant curvature are further investigated. As a highlight, this research is carried out by employing new state parameters [Formula: see text] and contributes to deeper understanding of the thermodynamics and phase structure of black holes. Our analyses manifest that the charged [Formula: see text]-CIM AdS black hole undergoes a first-order small–large black hole phase transition, and the critical behaviors qualitatively behave like a Van der Waals liquid–vapor system. However, differing from the case in Einstein’s gravity, phase structures of the black holes in [Formula: see text] theory exhibit an interesting dependence on gravity modification parameters. Moreover, we adopt the thermodynamic geometry to probe the black hole microscopic properties. The results show that, on the one hand, both the Ruppeiner curvature and heat capacity diverge exactly at the critical point, on the other hand, the [Formula: see text]-CIM AdS black hole possesses the property as ideal Fermi gases. Of special interest, we discover a microscopic similarity between the black holes and a Van der Waals liquid–vapor system.
10

McMullen, Allison R., Melanie L. Yarbrough, Meghan A. Wallace, Angela Shupe und Carey-Ann D. Burnham. „Evaluation of Genotypic and Phenotypic Methods to Detect Carbapenemase Production in Gram-Negative Bacilli“. Clinical Chemistry 63, Nr. 3 (01.03.2017): 723–30. http://dx.doi.org/10.1373/clinchem.2016.264804.

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Abstract BACKGROUND Carbapenemase-producing gram-negative bacteria (CP-GNB) are an urgent and expanding public health threat. Rapid and accurate identification of these organisms facilitates infection prevention efforts in healthcare facilities. The objective of our study was to evaluate methods to detect and identify CP-GNB. METHODS We examined 189 carbapenem-resistant GNB(CR-GNB), including Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii complex, using 3 different methods: 2 methods to screen isolates of GNB for carbapenemase production [the carbapenem inactivation method (CIM) and 2 chromogenic agars] and a molecular method (Cepheid GeneXpert Carba-R) to identify the mechanism of carbapenem resistance and the associated resistance genes (blaKPC, blaNDM, blaIMP, blaOXA-48-like, and blaVIM). RESULTS The CIM was a simple and inexpensive phenotypic screen to differentiate between CR-GNB and CP-GNB, with improved analytical performance characteristics and inter-reader correlation compared to the modified Hodge test. Both chromogenic agars evaluated (HardyCHROM CRE and chromID CARBA) were able to support growth of most of the organisms tested, including isolates possessing the blaOXA-48-like gene. However, these media had a low analytical specificity for carbapenemase production, with breakthrough of CR-GNB that did not produce a carbapenemase. The Xpert Carba-R assay was rapid and easy to perform, and demonstrated 100% positive and negative agreement for characterization of genetic determinants of carbapenem resistance. CONCLUSIONS Screening by CIM followed by the Xpert Carba-R PCR is an accurate method for detecting and characterizing CP-GNB, including Enterobacteriaceae, P. aeruginosa, and A. baumannii complex.
11

Kissow, H., B. Hartmann, J. Holst und S. Poulsen. „Glucagon-like peptide 1 (GLP-1) as treatment for chemotherapy induced mucositis (CIM)“. Regulatory Peptides 177 (August 2012): S24. http://dx.doi.org/10.1016/j.regpep.2012.05.045.

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12

CHANNAYYA, H., DA NAGEGOWDA, K. BASKARAN, RS VERMA, V. SUNDARESAN, P. GUPTA, KV ASHWINI et al. „Registration of high oil-yielding lemongrass (Cymbopogon flexuosus Steud.) Wats Variety CIM-Krishnapriya“. Journal of Medicinal and Aromatic Plant Sciences 45, Nr. 2 (12.12.2023): 70–78. http://dx.doi.org/10.62029/jmaps.v45i2.channayya.

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Lemongrass, a highly aromatic herb rich in citral content within its essential oil, serves diverse industries like fragrance, culinary, pharmaceuticals, and cosmetics. Traditional Indonesian cuisine benefits from its use as a spice, while it also contributes to Vitamin A production. Forecasts indicate a projected Compound Annual Growth Rate (CAGR) of 9.93% from 2021 to 2028, propelling the global lemongrass oil market from $41.98 million to $81.43 million. CSIR-CIMAP has diligently focused on advancing lemongrass cultivation and oil extraction through novel cultivars and agrotechnologies. Their efforts aim to elevate farmer income and cater to escalating lemongrass oil demands. A breakthrough cultivar, "CIM-Krishnapriya," has been introduced, poised to amplify lemongrass oil yield and subsequently augment farmers' earnings. This new cultivar boasts an herb yield of 25-30 t/ha and an oil yield of 300-320 kg/ha. Keywords: CIM-Krishnapriya, Citral, Cymbopogon flexuosus, Lemongrass, Poaceae
13

Lu, Anni, Xiaochen Peng, Yandong Luo, Shanshi Huang und Shimeng Yu. „A Runtime Reconfigurable Design of Compute-in-Memory–Based Hardware Accelerator for Deep Learning Inference“. ACM Transactions on Design Automation of Electronic Systems 26, Nr. 6 (28.06.2021): 1–18. http://dx.doi.org/10.1145/3460436.

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Compute-in-memory (CIM) is an attractive solution to address the “memory wall” challenges for the extensive computation in deep learning hardware accelerators. For custom ASIC design, a specific chip instance is restricted to a specific network during runtime. However, the development cycle of the hardware is normally far behind the emergence of new algorithms. Although some of the reported CIM-based architectures can adapt to different deep neural network (DNN) models, few details about the dataflow or control were disclosed to enable such an assumption. Instruction set architecture (ISA) could support high flexibility, but its complexity would be an obstacle to efficiency. In this article, a runtime reconfigurable design methodology of CIM-based accelerators is proposed to support a class of convolutional neural networks running on one prefabricated chip instance with ASIC-like efficiency. First, several design aspects are investigated: (1) the reconfigurable weight mapping method; (2) the input side of data transmission, mainly about the weight reloading; and (3) the output side of data processing, mainly about the reconfigurable accumulation. Then, a system-level performance benchmark is performed for the inference of different DNN models, such as VGG-8 on a CIFAR-10 dataset and AlexNet GoogLeNet, ResNet-18, and DenseNet-121 on an ImageNet dataset to measure the trade-offs between runtime reconfigurability, chip area, memory utilization, throughput, and energy efficiency.
14

Pfirrmann, Markus, Susanne Saussele, Michele Baccarani, Joelle Guilhot, Francisco Cervantes, Gert J. Ossenkoppele, Doris Lindoerfer et al. „Survival and Prognosis in Patients with First-Line Imatinib Treatment Under Particular Consideration of Death Due to Chronic Myeloid Leukemia“. Blood 124, Nr. 21 (06.12.2014): 153. http://dx.doi.org/10.1182/blood.v124.21.153.153.

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Abstract Introduction: The IN-study section of the European Treatment and Outcome Study (EUTOS) registry comprises data on imatinib-treated patients with chronic myeloid leukemia (CML) who were enrolled between 2002 and 2006 in prospective, controlled clinical trials. Of those, 2290 adult patients had Philadelphia chromosome-positive chronic-phase (CP) CML and were eligible for analysis and prognosis of long-term survival. Improved survival increased the percentage of deaths not related to CML. While adjusting for this, our analyses put death due to CML into focus. Aims: Based on the observed survival in our patient sample and on survival in matched population data, relative survival (RS) probabilities attributable to the excess hazard of CML should be calculated for the 2290 patients. These results were to be opposed to cumulative incidences of mortality (CIM) when only death due to CML is considered as an event and all other causes of death as competing risks. The ability to discriminate CIM of dying from CML should be assessed for the established prognostic models Sokal, Euro, and EUTOS score and a possibly identified new model. Candidate factors were age, sex, spleen enlargement, hemoglobin, platelets, leukocytes, and percentages of blasts, eosinophils, and basophils in peripheral blood. Methods:Survival time was calculated from the date of start of treatment to death or to the latest follow-up date. Survival was censored at the time of allogeneic stem cell transplantation in first CP. As “death due to CML”, only death after recorded disease progression was regarded. Progression was given by observation of accelerated phase or blast crisis, both defined in accordance with the recommendations of the ELN (Baccarani et al Blood 2013). RS probabilities were calculated by the method of Pohar-Perme (Comput Biol Med 2007) and CIM by the cumulative incidence function. Population data was downloaded from the Human Mortality Database (www.mortality.org). All prognostic factors were measured at baseline and the influence on CIM due to CML was estimated by the Fine and Gray (FG) model. Level of significance was 0.05. Results:The 2290 patients came from study groups in Germany, France, Italy, Spain, the Netherlands, and the Nordic study group and had a median observation time of 6.4 years. Observed 8-year overall survival probability was 89% [95% confidence interval (CI): 87-90%] and 8-year RS probability 96% [95% CI: 93-97%]. Cause of death was due to CML in 92 of 208 cases (44%), unrelated to CML in 104 (50%), and unknown in 12 cases (6%). Eight-year CIM were 4% [CI: 4-5%] for causes of death due to CML and 7% [CI: 6-8%] for causes of death due to other reasons, including the unknown causes where no progression prior to death was observed. From low to high risk groups, in 2205 evaluable patients, the Sokal score resulted in 8-year CIM of 3% [95% CI: 2-4%], 4% [95% CI: 3-6%], and 7% [n=499, 95% CI: 5-10%] and the Euro score in 8-year CIM of 4% [95% CI: 3-5%], 3% [95% CI: 2-4%], and 12% [n=222, 95% CI: 8-17%]. The EUTOS score suggested two groups with 8-year CIM of 4% [95% CI: 3-5%] and 9% [n=232, 95% CI: 5-13%]. Higher age, more blasts, a bigger spleen size enlargement, and low platelet counts significantly increased the CIM of dying from CML. The four factors were combined in a new prognostic model. Here, 8-year CIM were 2% [n=1349, 95% CI: 1-3%], 6% [n=596, 95% CI: 4-8%], and 11% [n=260, 95% CI: 8-16%]. Conclusions: An 8-year RS probability of 96% corresponded to an estimated 4% probability of dying due to CML which actually was the same result as the one calculated for the CIM. However, while for the first method, access to matched population data is necessary but no knowledge on the cause of death, in the second case, investigators need to assess whether an individual died from CML or not. Using the “progression prerequisite”, the FG model was most likely only based on “real” cases of death due to CML. As causes of death without prior progression, like infection or treatment-related toxicities, might well be attributable to CML, the CIM of death due to CML were supposedly underestimated. For assessment of comparability between patient samples, prognostic models built from baseline variables remain important. In comparison to other scores, only the new model identified three risk groups with pairwise significantly different CIM and led to the largest high-risk group with an 8-year CIM above 10%. Independent data for further comparisons are collected. Disclosures Pfirrmann: Novartis: Consultancy; Bristol-Myers Squibb: Honoraria. Saussele:Novartis: Honoraria, Research Funding, Travel grant Other. Baccarani:Novartis: Consultancy, Honoraria, Speakers Bureau; Bristol-Myers Squibb: Consultancy, Honoraria, Speakers Bureau; Pfizer: Consultancy, Honoraria, Speakers Bureau; Ariad: Consultancy, Honoraria, Speakers Bureau. Ossenkoppele:Novartis: Consultancy, Research Funding; Bristol-Myers Squibb: Consultancy, Research Funding. Lindoerfer:Novartis: Research Funding. Hoffmann:Novartis: Research Funding. Castagnetti:Novartis: Consultancy, Honoraria; Bristol-Myers Squibb: Consultancy, Honoraria. Hehlmann:Novartis: Research Funding; Bristol-Myers Squibb: Research Funding.
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Zhelin Li. „Optimized Multi-Scale Mixed Dense Graph Convolution Network for Career Impression Management in College Students Based on Social Network Analysis“. Journal of Electrical Systems 20, Nr. 3s (04.04.2024): 2738–48. http://dx.doi.org/10.52783/jes.3170.

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This investigation attempts to increase success rate of employment, entrepreneurship by addressing the dangers that college students face when seeking work and starting their own businesses in rural areas. It offers a way of social environment analysis based on employment, entrepreneurship of college students in rural areas. This approach comprehends the employment and social environment of college students' rural employment, entrepreneurship as research goal. It thoroughly examines, detects component parts of the college students' rural employment, entrepreneurship environment. In this manuscript, Optimized Multi-Scale Mixed Dense Graph Convolution Network for Career Impression Management in College Students Based on Social Network Analysis (MSMDGCN-CIM-CS-SNA) is proposed. Initially input data are gathered from Xing social network Dataset. To execute this, input data is pre-processed using Distributed Adaptive Cubature Information Filtering(DACIF) and it removes the noise from collected data; then the Pre-processed data are fed to MSMDGCN for effectively categorize Career Impression Management in College Students. In general, MSMDGCN does not express adapting optimization strategies to determine optimal parameters to ensure accurate Career Impression Management in College Students. Hence, the Sand Cat swarms optimization(SCSOA) to optimize Quantum Conditional Generative Adversarial Network which accurately Career Impression Management in College Students based on Social Media.Then the proposed MSMDGCN-CIM-CS-SNA is implemented and the performance metrics like Student Origin; Proportion of Daily Living Expenses, Student’s Graduation Trend, Selection of Career Areas for College Students, Units of College Student’s Career Intention and Computation Time the World are analyzed. Performance of the MSMDGCN-CIM-CS-SNA approach attains 18.75%, 26.89% and 32.57% higher Student’s Graduation Trend; 16.87%, 24.57% and 32.94% lower Units of College Student’s Career Intention and 18.43%, 25.64% and 31.40% lower Computation Time when analyzed through existing techniques like analysis on social environment of college students’ rural employment with entrepreneurship (ASE-CS-REE), recommendation model for college career entrepreneurship projects depend on deep learning (RM-CCE-DL), group relationship mining of college students depend on predictive social network (GRM-CS-PSN) methods respectively.
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Kamiya, M., F. Mizoguchi, H. Sasaki, N. Umezawa und S. Yasuda. „POS0472 AGONISTIC STIMULATION OF GLUCAGON-LIKE PEPTIDE-1 RECEPTOR AMELIORATED INFLAMMATORY MYOPATHIES THROUGH SUPPRESSING MUSCLE FIBER NECROPTOSIS“. Annals of the Rheumatic Diseases 81, Suppl 1 (23.05.2022): 490.2–491. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1437.

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BackgroundWhile glucocorticoids (GC) are the cornerstone of the treatment for polymyositis (PM), GC-induced myopathy is inevitable, which further deteriorates muscle weakness. Therefore, novel therapeutic strategy that not only suppresses muscle inflammation but also improves muscle strength is awaited. We recently found that injured muscle fibers in PM undergo FASLG-mediated necroptosis1, a form of regulated cell death accompanied with release of pro-inflammatory mediators such as HMGB1, which contributes to accelerate muscle inflammation and muscle weakness. We also showed that inhibition of necroptosis or HMGB1 ameliorated the muscle weakness and muscle inflammation1 in C protein-induced myositis (CIM), a murine model of PM. Glucagon-like peptide-1 receptor (GLP-1R) agonists, which have been developed as an anti-diabetic therapy, have pleiotropic actions including anti-inflammatory effects2, suppression of muscle wasting3, and inhibition of cell death4. Accordingly, we hypothesized that GLP-1R agonists have beneficial effects on PM to recover muscle strength and to suppress muscle inflammation.ObjectivesThe aims of this study are to examine the role of GLP-1R in PM and the effect of a GLP-1R agonist on in vivo and in vitro models of PM.MethodsMuscle specimens of PM patients and CIM were examined with immunofluorescence staining for the expression of GLP-1R. The effect of PF1801, a GLP-1R agonist, on CIM was examined in monotherapy or in combination with prednisolone (PSL). As an in vitro model of PM, C2C12-derived myotubes were treated with FAS ligand (FASLG) to induce necroptosis. The levels of HMGB1, TNF-α, and IL-6 in the serum of CIM and in the culture supernatant of the in vitro model were measured by ELISA. The effect of PF1801 on the myotube necroptosis was examined using time lapse imaging 5 and its effect on the activation of AMP-activated protein kinase (AMPK), the expression of PGAM5, and ubiquitination of PGAM5 was assessed with immunoblotting. The levels of reactive oxygen species (ROS) in the myotubes were analyzed with CellROX assay. The effect of PF1801 on the expression of antioxidant molecules in the myotubes was analyzed with quantitative real-time PCR.ResultsGLP-1R was expressed on the inflamed muscle fibers of PM and CIM. The treatment with PF1801 in monotherapy or in combination with PSL suppressed CIM-induced muscle weakness and the muscle weight loss as well as the severity of histological myositis while the monotherapy with PSL did not suppress muscle weakness and muscle weight loss. PF1801 decreased the levels of inflammatory mediators such as HMGB1, TNF-α, and IL-6 in the serum of CIM. In vitro, PF1801 inhibited FASLG-induced myotube necroptosis and decreased the levels of HMGB1, TNF-α, and IL-6 in the supernatant. PF1801 activated AMPK and decreased the levels of PGAM5, which was crucial for FASLG-induced necroptosis of the myotubes. The inhibitory effect of PF1801 on myotube necroptosis was cancelled by compound C, an AMPK-kinase inhibitor, or MG132, a proteasome inhibitor, suggesting that PF1801 promoted ubiquitin-proteasome-mediated PGAM5 degradation through the activation of AMPK. Furthermore, PF1801 suppressed FASLG-induced reactive oxygen species (ROS) accumulation in myotubes, which was also crucial for the execution of necroptosis, thorough up-regulating the antioxidant molecules such as Nfe2l2, Hmox1, Gclm, and Nqo1.ConclusionGLP-1R agonist could be a novel therapy for PM that restores muscle strength as well as suppresses muscle inflammation through inhibiting muscle fiber necroptosis.References[1]Kamiya M, et al. Nat Commun. 2022;13:166[2]Du X, et al. Int Immunopharmacol. 2019;75:105732.[3]Hong Y, et al. J Cachexia Sarcopenia Muscle. 2019;10:903–918.[4]Younce CW, et al. Am J Physiol - Cell Physiol. 2013;304:508–518.[5]Kamiya M, et al. Rheumatology (Oxford). 2020; 59:224-232AcknowledgementsWe thank Katsuko Yamasaki for the histological analysis.Disclosure of InterestsMari Kamiya Speakers bureau: Pfizer and Ono Pharmaceutical, Grant/research support from: GlaxoSmithKline, Fumitaka Mizoguchi Speakers bureau: AbbVie, Asahi Kasei Pharma, Bristol-Myers Squibb, Chugai Pharmaceutical, Eizai, Eli Lilly and Company, Glaxo Smith Kline, Ono Pharmaceutical, and Pfizer., Consultant of: Asahi Kasei Pharma and ImmunoForge., Grant/research support from: AbbVie, Astellas Pharma, Bristol-Myers Squibb, Chugai Pharmaceutical, Daiichi Sankyo Company, Eisai, Eli Lilly and Company, ImmunoForge, Japan Blood Products Organization, Mitsubishi Tanabe Pharma, Novartis Pharma Japan, Ono Pharmaceutical, Otsuka Pharmaceutical Factory, Pfizer, Sanofi, Takeda Pharmaceutical Company and Teijin, Hirokazu Sasaki: None declared, Natsuka Umezawa: None declared, Shinsuke Yasuda Speakers bureau: Abbvie, Asahi Kasei Pharma, Chugai Pharmaceutical, Eisai, Eli Lilly, GlaxoSmithKline, Mitsubishi Tanabe Pharma, Ono pharmaceutical, and Pfizer., Consultant of: ImmunoForge, Grant/research support from: Abbvie, Asahi Kasei Pharma, Chugai Pharmaceutical, CSL Behring, Eisai, ImmunoForge, Mitsubishi Tanabe Pharma, and Ono pharmaceutical.
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Xia, Zhipeng, Bingkui Miao, Chuantong Zhang, Hongyi Chen, Lanfang Xie, P. M. Ranjith, Yikai Zhang und Bowen Si. „Petrography and Shock Metamorphism of the Lunar Breccia Meteorite NWA 13120“. Minerals 11, Nr. 8 (20.08.2021): 899. http://dx.doi.org/10.3390/min11080899.

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Lunar meteorites are the fragments of rocks that fell on Earth because of the impacts of asteroids on the Moon. Such rocks preserve information about the composition, evolutionary process, and shock history of the lunar surface. NWA 13120 is a recently discovered lunar breccia meteorite having features of strong shock, which is composed of lithic and mineral clasts in a matrix of very fine-grained (<10 μm) and recrystallized olivine-plagioclase with a poikilitic-like texture. As the most abundant lithic clasts, the crystalline impact melt (CIM) clasts can be divided into four types according to their texture and mineral composition: (1) anorthosites or troctolitic anorthosite with a poikilitic-like texture, but the mineral content is different from that of the matrix; (2) anorthosites containing basaltic fragments and rich in vesicles; (3) troctolitic anorthosite containing metamorphic olivine mineral fragments; (4) troctolitic anorthosite containing troctolite fragments. Based on the petrology and mineralogy, NWA 13120 is a lunar meteorite that was derived from the ferrous anorthosite suite (FANs) of the lunar highlands, while its texture suggests it is a crystalline impact melt breccia. In addition, we infer that the parent rock of NWA 13120 is a lunar regolith breccia enriched in glass fragments. During the shock process, at pressures of more than 20 GPa, all plagioclase fragments were transformed into maskelynites, and olivine fragments occurred metamorphism. The post-shock temperature led to the partial melting of the basaltic fragments. Subsequently, all glass with diverse components in the parent rock were devitrified and recrystallized, forming the common olivine-plagioclase poikilitic-like texture and different CIM clasts. Meanwhile, the devitrification of maskelynite formed the accumulation of a large number of plagioclase microcrystals. Therefore, NWA 13120 is a meteorite of great significance for understanding the local shock metamorphism of lunar rocks on the lunar surface.
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Qi, Longning, Jinqi Fan, Hao Cai und Ze Fang. „A Survey of Emerging Memory in a Microcontroller Unit“. Micromachines 15, Nr. 4 (01.04.2024): 488. http://dx.doi.org/10.3390/mi15040488.

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In the era of widespread edge computing, energy conservation modes like complete power shutdown are crucial for battery-powered devices, but they risk data loss in volatile memory. Energy autonomous systems, relying on ambient energy, face operational challenges due to power losses. Recent advancements in emerging nonvolatile memories (NVMs) like FRAM, RRAM, MRAM, and PCM offer mature solutions to sustain work progress with minimal energy overhead during outages. This paper thoroughly reviews utilizing emerging NVMs in microcontroller units (MCUs), comparing their key attributes to describe unique benefits and potential applications. Furthermore, we discuss the intricate details of NVM circuit design and NVM-driven compute-in-memory (CIM) architectures. In summary, integrating emerging NVMs into MCUs showcases promising prospects for next-generation applications such as Internet of Things and neural networks.
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ASIF, M. „COTTON GERMPLASM CHARACTERIZATION FOR DROUGHT TOLERANCE BASED ON MORPHO-PHYSIOLOGICAL AND FIBER QUALITY PARAMETERS“. SABRAO Journal of Breeding and Genetics 55, Nr. 4 (31.08.2023): 1079–93. http://dx.doi.org/10.54910/sabrao2023.55.4.6.

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Drought tolerance is a quantitative trait that is exceedingly challenging to breed, especially for allotetraploids like cotton. The scenario of limited water resources necessitates developing droughttolerant cultivars that conserve significant irrigation water throughout the summer. Therefore, the presented study used a design to statistically analyze the morphological, physiological, and fiber quality parameters linked with drought tolerance, which is a comprehensive method for choosing better genotypes from the available cotton germplasm. Measuring these parameters ensued for plants grown under field conditions. The germplasm comprised 150 cotton genotypes studied at two water regimes, i.e., regular and water-stressed conditions for two consecutive seasons of 2015–2016 and 2016–2017. Data recording ran for different morpho-physiological and fiber quality parameters. Significant differences occurred for all the treatments, genotypes, and Genotype × Environment interaction for all the morphological, physiological, and fiber quality parameters under study. Additive Main effects and Multiplicative Interaction (AMMI) analysis and AMMI biplot analysis helped analyze the results, which revealed that the cotton genotypes FH-900, FH-901, FH-312, AS-1, AS-2, AS-3, RH510, RH-627, AR-2, AR-9, BH-118, BH-175, SLH-74, CIM-1100, CIM-598, and MM-58 were drought tolerant and ranked highest concerning stress condition. Moreover, correlation studies distinguished the relationship between relevant traits concerning drought tolerance.
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Shang, Baoshuan, Chongyi Xu, Xixi Zhang, Huifen Cao, Wei Xin und Yuxin Hu. „Very-long-chain fatty acids restrict regeneration capacity by confining pericycle competence for callus formation in Arabidopsis“. Proceedings of the National Academy of Sciences 113, Nr. 18 (18.04.2016): 5101–6. http://dx.doi.org/10.1073/pnas.1522466113.

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The already differentiated organs in plants have a remarkable capacity to regenerate new individuals under culture conditions. Plant in vitro regeneration practically starts with the induction of a pluripotent cell mass, the callus, from detached organs on auxin-rich callus-inducing medium (CIM), which is generally required for subsequent regeneration of new bodies. Recent studies show that CIM-induced callus formation occurs from the pericycle or pericycle-like cells through a root developmental pathway, whereas the signals involved in governing callus-forming capacity of pericycle cells remain unknown. Here we report that very-long-chain fatty acids (VLCFAs) play a critical role in confining the pericycle competence for callus formation and thus the regeneration capacity of Arabidopsis. By genetic screening, we identified the callus formation-related 1 (cfr1) mutant, which bypasses the inhibition of callus-forming capacity in roots by solitary-root (slr/iaa14). We show that CFR1 encodes 3-ketoacyl-CoA synthase 1 (KCS1), which catalyzes a rate-limiting step of VLCFA biosynthesis. Our biochemical and genetic analyses demonstrate that VLCFAs restrict the pericycle competence for callus formation, at least in part, by regulating the transcription of Aberrant Lateral Root Formation 4 (ALF4). Moreover, we provide evidence that VLCFAs act as cell layer signals to mediate the pericycle competence for callus formation. Taken together, our results identify VLCFAs or their derivatives as the confining signals for mediating the pericycle competence for callus formation and thus the regeneration capacity of plant organs.
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Thorwartl, Christoph, Josef Kröll, Andreas Tschepp, Helmut Holzer, Wolfgang Teufl und Thomas Stöggl. „Validation of a Sensor-Based Dynamic Ski Deflection Measurement in the Lab and Proof-of-Concept Field Investigation“. Sensors 22, Nr. 15 (02.08.2022): 5768. http://dx.doi.org/10.3390/s22155768.

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Introduction: Ski deflection is a performance-relevant factor in alpine skiing and the segmental and temporal curvature characteristics (m−1) along the ski have lately received particular attention. Recently, we introduced a PyzoFlex® ski deflection measurement prototype that demonstrated high reliability and validity in a quasi-static setting. The aim of the present work is to test the performance of an enhanced version of the prototype in a dynamic setting both in a skiing-like bending simulation as well as in a field proof-of-concept measurement. Material and methods: A total of twelve sensor foils were implemented on the upper surface of the ski. The ski sensors were calibrated with an empirical curvature model and then deformed on a programmable bending robot with the following program: 20 times at three different deformation velocities (vslow, vmedium, vfast) with (1) central bending, (2) front bending, (3) back bending, (4) edging left, and (5) edging right. For reliability assessment, pairs of bending cycles (cycle 1 vs. cycle 10 and cycle 10 vs. cycle 20) at vslow, vmedium, and vfast and between pairs of velocity (vslow vs. vmedium and vslow vs. vfast) were evaluated by calculating the change in the mean (CIM), coefficient of variation (CV) and intraclass correlation coefficient (ICC 3.1) with a 95% confidence interval. For validity assessment, the calculated segment-wise mean signals were compared with the values that were determined by 36 infrared markers that were attached to the ski using an optoelectrical measuring system (Qualisys). Results: High reliability was found for pairs of bending cycles (CIM −0.69–0.24%, max CV 0.28%, ICC 3.1 > 0.999) and pairs of velocities (max CIM = 3.03%, max CV = 3.05%, ICC 3.1 = 0.997). The criterion validity based on the Pearson correlation coefficient was r = 0.98. The accuracy (systematic bias) and precision (standard deviation), were −0.003 m−1 and 0.047 m−1, respectively. Conclusions: The proof-of-concept field measurement has shown that the prototype is stable, robust, and waterproof and provides characteristic curvature progressions with plausible values. Combined with the high laboratory-based reliability and validity of the PyzoFlex® prototype, this is a potential candidate for smart ski equipment.
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GUPTA, AK, R. MISHRA, D. SAIKIA, K. SHANKER, AS NEGI, S. TANDON, A. KALRA et al. „Registration of a High Rhizome and High Curcuminoid Yielding Variety of Turmeric (Curcuma longa L) CIM-Pitamber“. Journal of Medicinal and Aromatic Plant Sciences 39, Nr. 1 (01.07.2017): 49–54. http://dx.doi.org/10.62029/jmaps.v40i1.gupta2.

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Curcuma longa L. (Zingiberaceae), commonly known as turmeric, is not only one of the most popular spices for Indian cuisines, is also one of the most valuable medicinal plants of traditional systems of Indian medicine due to its numerous preventive and curative effects. The pharmaceutical importance of turmeric is due to the presence of linear diarylheptanoidal phenolic molecules that are collectively called as curcuminoids like curcumin, demethoxycurcumin and bisdemethoxycurcumin. These compounds are credited with anti-inflammatory, hypocholesterolemic, anti-oxidant, anti-parasitic, anti-spasmodic, antimicrobial, anti-rheumatic, anti-aging and anti-cancer properties. Extensive R&D efforts made during last eight years at CSIR-CIMAP have resulted in the identification of superior clones that can yield more than 50 tons of rhizomes/ha containing more than 10% content of curcuminoids. One such clone rechristened as CIM-Pitambar has been identified, that can produce 60-65 tons rhizomes/ha containing 12.5% curcuminoids in a relatively short span of 180-190 days. This variety has been developed using the method of cloline breeding approach. Among 130 germplasm accessions/clones collected from different parts of India, single plants/clone selection was performed. This variety is also tolerant to leaf blotch disease of turmeric. This variety provides more than 54% higher rhizomes with 92% more curcuminoids, yielding around 165% more curcuminoids/ha than the cultivar IISR Pratibha, Which is the most commonly cultivated variety in North Indian plains. The introduction of CIM-Pitamber in cultivation will enable farmers to double their yield and profits per unit area, and thus will significantly improve the livelihood of poor farmers.
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GUPTA, ANIL KUMAR, MADAN MOHAN GUPTA, TRIPTA JHANG, LATE RAVINDRA SAINI, DHARMENDRA DHARMENDRA SAIKIA, RAJ KISHORI LAL, LATE HARI OM MISHRA et al. „‘CIMAP SIL-9’: A Dwarf and High Silymarin Yielding Variety of Milk Thistle (Silybum marianum)“. Journal of Medicinal and Aromatic Plant Sciences 39, Nr. 1 (01.07.2017): 44–48. http://dx.doi.org/10.62029/jmaps.v39i1.gupta.

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Silybum marianum commonly known as milk thistle is a herb belonging to the family Asteraceae. The ripe seeds of the plant contain silymarin which is used as medicine for treating diseases like liver cirrhosis, jaundice, hepatitis and liver poisoning. Other major medicinal properties of Silybum are anticancer, antidepressant, antioxidant, cardio protective, demulcent, digestive tonic, hepatoprotective, hepatoregenerative, immunostimulatory and neuroprotective. A new variety of Silymarin named as “CIMAP SIL 9” has been developed by CSIR-CIMAP through directed breeding efforts. The developed variety has silymarin content of 8% and has an appropriate height of 80-90 cm, making its harvesting very easy. Whereas, the check (CIM Liv) is very tall which makes its handling very difficult. The variety therefore has a dual advantage of dwarfness combined with very high content of silymarin.
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KUMAR, A., RK LAL, AK GUPTA und CS CHANOTIYA. „Historical and contemporary development of novel chemotype varieties with high essential oil of lemongrass in India: A review“. Journal of Medicinal and Aromatic Plant Sciences 45, Nr. 1 (23.12.2023): 17–27. http://dx.doi.org/10.62029/jmaps.v45i1.kumar.

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Lemongrasses found in India encompass Cymbopogon flexuosus, C. citratus, C. khasianus, and C. pendulus. This fragrant perennial grass belongs to the Poaceae family and is indigenous to India as well as other tropical and subtropical regions in Southeast Asia and Africa. Pinpointing its precise place of origin is challenging due to its extensive history of cultivation and utilization across various cultures. It is believed to have originated in the maritime Southeast Asian region, encompassing countries like India, Sri Lanka, Indonesia, and Malaysia. Lemongrass thrives in these regions and has played a significant role in their culinary and medicinal traditions for many generations. Among these, Cymbopogon citratus, a tropical lemongrass variety, is native to multiple Asian regions, particularly Southeast Asia and South Asia. It is widely cultivated and employed in a range of global cuisines and traditional healing practices. Lemongrass finds extensive applications in the herbal, medicinal, cosmetic, pharmaceutical, and fragrance industries. Lemongrass oil is known for its diverse biological properties, which encompass antibacterial, immunomodulatory, and antioxidant effects. Not too long ago, India ranked as one of the world' leading exporters of lemongrass essential oil. Several prominent lemongrass cultivars have emerged, including GRL-1 (geraniol-rich), Krishna, Cauveri, Pragati, Praman, T-1, CIM Shikhar, Chirharit, CKP-25, SD-68, CIMAP Suwarna, and Krishnapriya. Among these, CIMAP Suwarna, Krishna, and CIM Shikhar stand out as the most widely favoured varieties across India developed at the CSIR-CIMAP in Lucknow, India. Indian universities and research institutions have also played a pivotal role in the development of novel lemongrass cultivars. Examples include Jor Lab L-2, OD-19, SD-68 (C. flexuosus), RRL-16 (C. pendulus), and CKP-25. Notably, there's Jor Lab L-9, a distinctive strain of C. khasianus known for its high methyl eugenol content. Furthermore, the germplasm for Malabar lemongrass (C. khasianus) is notable for its abundant herbage and elevated elemicin content, reaching up to 70%. The CSIR-NEIST in Jorhat and the CSIR-CIMAP, Lucknow have contributed to the development of new high geraniol-rich lemongrass cultivars, such as "Jor Lab L-15" (C. khasianus), GRL-1, and CIM Atal (C. flexuosus), respectively. b: citral, elemicin, geraniol, methyl eugenol content, vitamin A, Cymbopogon, flexuosus, Cymbopogon pendulus, Cymbopogon khasianus, Cymbopogon citratus, Lemongrass varieties Citral, Cymbopogon citratus, Cymbopogon flexuosus, Cymbopogon khasianus, Cymbopogon pendulus, Elemicin, Geraniol, Lemongrass varieties, Methyl eugenol content, Vitamin A
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Peng, Yi, Bei Luo und Chenxing Xiao. „Enriching Knowledge Representation of Terminology“. Lexicography 9, Nr. 1 (08.06.2022): 44–78. http://dx.doi.org/10.1558/lexi.20443.

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Whereas a number of studies have been conducted towards representing knowledge linked with terms, terminological knowledge still demands further exploration due to its diversity and intricacy. Although much recent cognitive terminological research has examined either frames or event structures based on specialized contexts and hence has helped improve the clarification of relevant knowledge representation, other types of knowledge structures tied to terms like metaphoric and metonymic structures as well as conceptual blending processes of terms have not yet been adequately investigated. In view of this gap, we put forward a cognitive integrated model (CIM), attempting to integrate cognitive structures and construction of terms in a holistic manner. In this study, we mainly center on integration of the decontextualized part: the adapted (ECM1), conceptual metaphor (CM1), conceptual metonymy (CM2), and conceptual blending (CB1) in light of terminological definitions without context, acting as offline knowledge of terms. Integration of the contextualized part is briefly discussed, merely about the adjusted ECM within context (ECM2) as online knowledge. The tentative incorporation of both offline and online knowledge of terms derives at least five particular variants of the CIM: ECM1+ECM2, ECM1+CB1+ECM2, ECM1+CM1+CB1+ECM2, ECM1+CM2+CB1+ECM2, ECM1+CM1+CM2+CB1+ECM2. Accordingly, both definition-based and usage-based methods are exploited, respectively backed up by dictionaries or professional works and corpora, etc. We subsequently apply the five variants to representing Event-Domain Cognitive Model knowledge of international trade terms previously seldom explored in terminology. It turns out that the cognitive integrated perspective contributes to enriching knowledge representation of the terms by exposing diverse knowledge structures and conceptual construction.
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Saavedra, Sandra Yamile, Johan Fabian Bernal, Efrain Montilla-Escudero, German Torres, Mabel Karina Rodríguez, Andrea Melissa Hidalgo, María Victoria Ovalle, Sandra Rivera, Enrique Perez-Gutierrez und Carolina Duarte. „Vigilancia nacional de aislamientos clínicos de Enterococcus faecalis resistentes al linezolid portadores del gen optrA en Colombia, 2014-2019“. Revista Panamericana de Salud Pública 44 (22.09.2020): 1. http://dx.doi.org/10.26633/rpsp.2020.104.

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Objetivo. Describir las características epidemiológicas, fenotípicas y genéticas de aislamientos clínicos portadores de optrA identificados en la vigilancia de resistencia antimicrobiana por el laboratorio del Instituto Nacional de Salud de Colombia. Métodos. Entre octubre de 2014 y febrero 2019, se recibieron 25 aislamientos de Enterococcus spp. resistentes al linezolid. La identificación y sensibilidad antimicrobiana se determinó con Vitek 2 y la concentración inhibitoria mínima (CIM) al linezolid se estableció con E-test. El gen optrA se detectó mediante PCR. La diversidad genética de aislamientos positivos para optrA se analizó con Diversilab®. Se seleccionaron seis aislamientos para llevar a cabo la secuenciación del genoma completo. Resultados. Se confirmó el gen optrA en 23/25 aislamientos de E. faecalis de siete departamentos de Colombia. Los aislamientos presentaron una CIM al linezolid entre 8 y >256µg/mL. La tipificación por Diversilab® indicó una amplia variabilidad genética. Todos los aislamientos analizados mediante secuenciación del genoma completo, presentaron genes de resistencia fexA, ermB, lsaA, tet(M), tet(L) y dfrG además de optrA y fueron negativos para otros mecanismos de resistencia al linezolid. Se identificaron tres secuencias tipos y tres variantes de optrA: ST16 (optrA-2), ST476 (optrA-5) y ST618 (optrA-6). El entorno genético de los aislamientos optrA-2 (ST16) presentó el segmento impB, fex, optrA, asociado a plásmido, mientras que en dos aislamientos (optrA-6 y optrA-5) se encontró el elemento cromosómico transferible Tn6674-like. Conclusión. Los aislamientos clínicos positivos para optrA presentan una alta diversidad genética, con diferentes clones y variantes de optrA relacionados con dos tipos de estructuras y diferentes elementos genéticos móviles.
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Pavlovici, Bogdan. „The Contribution of Systemic Modelling and of Early Maladaptive Schema in Psychiatric Expertise“. BRAIN. Broad Research in Artificial Intelligence and Neuroscience 15, Nr. 1 (06.02.2024): 352–61. http://dx.doi.org/10.18662/brain/15.1/556.

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There are limits in international classifications like DSM 5, CIM 10, which are periodically updated in order to adapt to the constantly changing psychiatric field. Furthermore, the DSM 5 does not allow the mention of a personality disorder before 18 years of age. The modelling proposed by Jeffrey Young-American psychologist-, that of « early maladaptive schema » provide a way out of stagnation by bringing vulnerabilities to the forefront. These may, from an expertal viewpoint, explain some psychological processes that may lead to delinquent behaviours or become fertile ground for agression and development of psychological trauma. The modelling proposed by various systemic theory scientists allows for a more in depth explanation of progressive build-up of a pathology through repeat dysfunctional systemic interactions. This contribution is very useful in judicial but also familial expertise. I will illustrate my remarks through two clinical studies.
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Abu Bakar, Mimi Azlina, Siti Norazlini Abd Aziz und Muhammad Hussain Ismail. „Tribology study of hydroxyapatite (HAp) scaffold blended single based binder via rheology and mechanical properties“. Industrial Lubrication and Tribology 69, Nr. 3 (08.05.2017): 414–19. http://dx.doi.org/10.1108/ilt-09-2016-0228.

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Purpose This paper aims to investigate the vital characteristic of an innovative ceramic injection molding (CIM) process for orthopedic application with controlled porosity and improved tribological and mechanical properties which were affected by complex tribological interactions, whether lubricated like hip implants and other artificial prostheses. The main objective is to maximize the usage of palm stearin as a single based binder as the function of flow properties during injection molding process. Design/methodology/approach The binder used in this present study consists of 100 per cent palm stearin manufactured by Kempas Oil Sdn Bhd and supplied by Vistec Technology Sdn Bhd. The feedstock was prepared by using a Z-blade mixer (Thermo Haake Rheomix OS) and Brabender mixer model R2400. The feedstock prepared was injection molded using a manually operated vertical benchtop machine with an average pressure of about 5-7 bars. The firing step included the temporary holds at intermediate temperatures to burn out organic binders. At this stage, the green molded specimen was de-bound using a single-step wick-debinding method. Findings The maximum content of ceramic material is applied to investigate the efficiencies of net formulation that can be achieved by ceramic materials. The longer the viscosity will change with shear rate, the higher the value of n obtained instead. From the slope of the curves obtained in Figure 3, the value of n for the feedstock was determined to be less than 1, which indicates a pseudoplastic behavior and suitability for the molding process. Moreover, high shear sensitivity is important in producing complex and intrinsic specimens which are leading products in the CIM industry. Originality/value The feedstock containing HAp powder and palm stearin binder was successfully prepared at very low temperature of 70°C, which promoting a required pseudo-plastic behavior during rheological test. The single binder palm stearin should be optimized in other research works carried out, as palm stearin is most preferred compared to other polymeric materials that provided high energy consumption when subjected to the sintering process. Besides the binder is widely available in Malaysia, low cost and harmless effect during debinding process.
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Zanello, A., J. P. Bacchetta, S. Quast und M. Merlo. „Crisis treatments: improvements in symptomatic, defense mechanisms, recovery style and social functioning“. European Psychiatry 26, S2 (März 2011): 1765. http://dx.doi.org/10.1016/s0924-9338(11)73469-1.

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The challenge in crisis intervention is to seize the potential of change while giving the patients enough support and security as well as maintaining social integration. Crisis Intervention Centers (CIC) provide an alternative to psychiatric hospitalization for patients that are treated in an affiliated outpatient structure.The aim of this study was to verify the short term effects of a brief (6 weeks) intensive crisis psychodynamic oriented treatment including individual and group therapy associated with pharmacotherapy.One hundred and fourteen middle age (m = 41 years, SD = 11.7) patients were included: 68 women and 46 men with disorders like depression (75.4%), anxiety (18.4%) or others (6.2%) according to CIM-10. They were administered measures of psychopathology (BPRS 4.0 and SCL-90 R), defense mechanisms (DSQ-40), global functioning (GAF) and recovery style (RSQ) at intake and 2 weeks after discharge.At endpoint, a statistical significant reduction in the severity of symptoms was found in all variables except for hostility and phobic dimensions of SCL-90 R. This was associated with significant improvements in recovery style scores, global functioning and a shifting towards more mature defense mechanisms. None of the improvements were related to gender.These findings provide clear evidence of the effectiveness of brief psychodynamic oriented crisis interventions in specific units like CIC. Further research is needed to clarify whether the improvements remain stable on the long run and whether crisis treatments pave the way for future psychotherapeutic treatments.
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Mikuła, Anna, Maria Wesołowska, Józef Kapusta, Lutosława Skrzypczak und Jan J. Rybczyński. „Cytomorphological studies on somatic embryogenesis of Gentiana tibetica (King) and G. cruciata (L.)“. Acta Societatis Botanicorum Poloniae 65, Nr. 1-2 (2014): 47–51. http://dx.doi.org/10.5586/asbp.1996.008.

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The process of plant regeneration via somatic embryogenesis of two gentianas, <em>Gentiana tibetica</em> and <em>G. cruciata</em> was described. For this purpose seedling explants were cultured on agar medium and later maintained in cell suspension. For callus initiation seedling explants like: cotyledons, hypocotyl and root were plated on a callus induction medium (CIM) composed of MS (1962), supplemented with 0.5 mg/l 2,4-D and 1.0 mg/l Kin. For the formation of cell suspension culture, embryogenic callus was transferred into liquid maintained medium (MM) composed of MS (1962), supplemented with 1.0 mg/l Dic + 0.1 mg/l NAA + 2.0 mg/l BAP + 80.0 mg/l SA. The conversion of somatic embryo into plantlets required a new medium (ECM) based on MS (1962) mineral salts, supplemented with 0.5 mg/l GA<sub>3</sub> + 1.0 mg/l Kin + 0.5 mg/l NAA. For cytomorphological studies of particular stages of embryogenesis, specimens were stained with dyes and reagents: 1. PAS reaction with leukofucsin, 2. Safranin + fast green, 3. Erlich's hematoxylin.
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HUSSAIN, Z., M. MUZAMIL, MR SAEED, K. NAHEED, M. KAREEM, A. MUNIR, MZ HAIDER und A. SAMI. „TRAIT CORRELATIONS AND IMPLICATIONS FOR YIELD POTENTIAL IN COTTON: A COMPREHENSIVE STUDY“. Biological and Agricultural Sciences Research Journal 2023, Nr. 1 (11.08.2023): 24. http://dx.doi.org/10.54112/basrj.v2023i1.24.

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Cotton (Gossypium spp.) yield improvement is a primary objective for breeders and researchers. This study explores trait correlations and their impact on cotton yield potential. Through field experiments and statistical analyses, relationships between traits and yield to provide insights for cotton breeding programs was investigated. Results revealed significant associations between traits and cotton yield. Plant height, number of nodes, monopodial branches and open ball showed positive correlations with yield. Taller plants, increased sympodial branches and more open balls were linked to higher yield potential. SS32 RH-668, NIAB-KIRAN and CIM-599 per form better among 19 genotypes. Further research is needed to establish causality. The study emphasizes that when selecting cotton genotypes for better yield potential, it's crucial to consider traits like sympodial branches, boll weight, open ball and green ball. Understanding their direct and indirect effects can help breeders develop varieties with desired characteristics and maximize yield. Additionally, the study found significant genetic variability among tested genotypes creating opportunities for breeding programs to enhance yield and desired traits. These findings offer valuable insights into trait correlations, paving the way for future research on genetics and the development of better cotton varieties to meet global demand.
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KHAN, MF, SAS SHAH und T. MANZOOR. „GENOTYPIC VARIABILITY AND TRAIT ASSOCIATION IN COTTON (GOSSYPIUM HIRSUTUM L.) SEEDLINGS UNDER NORMAL AND DROUGHT CONDITIONS“. Biological and Clinical Sciences Research Journal 2023, Nr. 1 (24.01.2023): 266. http://dx.doi.org/10.54112/bcsrj.v2023i1.266.

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The genetic variability and correlation parameter studies for seedling traits viz; fresh root length, fresh shoot length, fresh shoot weight, dry shoot weight, tissue moisture percentage and root/shoot ratio in 40 accessions of cotton germplasm, including both local and exotic available at different research stations and institutes of Pakistan were carried out under greenhouse in the department of Plant Breeding and Genetics, University of Agriculture, Faisalabad, during the year 2006. Sufficient genetic variability was observed for seedling characters like root length, shoot length, shoot fresh weight, shoot dry weight, tissue moisture percentage and root/shoot ratio under normal and water stress conditions. Based on rooting character and root/shoot ratio, three drought-tolerant cotton genotypes 149-F, BH-124 and DPL-26 and three drought susceptible VH-28, FH-945 and CIM-446 were selected. Correlation coefficients under normal conditions were greater than under drought stress, and the direction of correlations of seedling traits in most cases remained the same. Under normal (r = 0.72) and drought (r = 0.48) conditions, shoot length and root length, were positively correlated, indicating a corresponding increase in shoot length with an increase in root length and vice versa.
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Yan Shan, Tai, Faruque Reza, Tahamina Begum und Nasir Yusoff. „Neural Processing of Other-Race Faces as a Function of Racial Familiarity: A P300 Study“. International Journal of Engineering & Technology 7, Nr. 3.22 (08.08.2018): 21. http://dx.doi.org/10.14419/ijet.v7i3.22.17116.

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Background: The other-race categorisation advantage (ORCA) is a well-established phenomenon, whereby other-race faces are categorised faster than own race faces. Objectives: This study investigated whether extraverts would demonstrate an ORCA-like effect toward unfamiliar other-race faces and familiar other-race faces in a modified oddball and choice reaction paradigm. Methods: This event-related potential (ERP) study employed a repeated measures experimental design with one independent variable (racial familiarity) and three levels (familiar other-race/Malay faces, unfamiliar other-race/African faces, control group/furniture photos). In the oddball task, African faces and Malay faces were the target stimuli and furniture photos were the standard stimuli. Electroencephalography data (EEG) was collected during the oddball task, from which ERP components were derived. Results: The reaction time (RT) for African and Malay faces were not significantly different. Significant effect of racial familiarity on P300 latencies at all electrode sites was not observed. However, there was a significant effect of racial familiarity on P300 amplitudes at midline electrodes (Cz). It was also observed that the P300 amplitude was larger for African faces than Malay faces at midline electrodes (Cz). Conclusion: An ORCA-like effect was not found in categorisation tasks involving faces from a familiar and an unfamiliar other-race, but a larger P300 amplitude was evoked by African faces. This dissociation between RT and P300 amplitude provided important theoretical implications with regard to models associated with ORCA. Specifically, the current findings lent support to the social cognition model and the Categorisation-Individuation Model (CIM).
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Recio, C., A. E. Fallick und J. M. Ugidos. „A stable isotopic (δ18O, δD) study of the late-Hercynian granites and their host-rocks in the Central Iberian Massif (Spain)“. Earth and Environmental Science Transactions of the Royal Society of Edinburgh 83, Nr. 1-2 (1992): 247–57. http://dx.doi.org/10.1017/s0263593300007938.

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ABSTRACTStable isotopic ratios (mainly 18O/16O, but also D/H) have been measured for the three most important types of late-Hercynian granites, and their hosts, in the western area of the Central Iberian Massif (CIM), Spain. These granites are amphibole-bearing biotite granites, biotite granites and cordierite-bearing biotite granites. No intrusive relationships have been observed among them; the contact of each granite with the others is always gradational. Host-rocks are Precambrian/Cambrian metasediments, ranging from low-grade schists to migmatites (nebulites).Whole-rock δ18OSMOW values are as follows: amphibole-bearing biotite granites 8·9 ± 0·58% (1σ, n = 17); biotite granites 9·0 ± 0·35% (1σ, n = 11); cordierite-bearing biotite granites 9·6 ± 0·24% (1σ, n = 21). δ18O values for nebulites, into which some of these granites were emplaced, are significantly higher, at 11·1 ± 0·58‰ (1σ, n = 13). The Precambrian to Cambrian shales gave an average value of δ18O = 11·9 ± l·23‰ (lδ, n = 5). Whole-rock oxygen isotope ratios indicate that the origin of the granites was in neither purely sedimentary/metasedimentary rocks nor pristine mantle melts. δ18O values close to 9·0‰ require a crustal protolith, having an important recycled component.Oxygen isotope results are compatible with the cordierite-bearing granites being generated by assimilation of nebulite-like material by a biotite granite magma. However, 18O/16O of mineral separates obtained from the three different granites and the nebulite indicate that isotopic equilibrium, if ever reached, has not been preserved. The modified isotopic equilibrium is attributed to fluid activity, but mineral-pair δ-δ plots suggest that the granite system behaved as a closed system, and that the fluid was deuteric (magmatic) in origin. This implies that if assimilation did happen, it occurred at a temperature higher than the closure temperature of the different minerals to isotopic exchange. In a δ18O vs δD plot, hornblende and biotite separates from the granites plot within the igneous field. A simple mesocrustal anatectic origin for the peraluminous late Hercynian granites of the western area of the CIM is difficult to sustain on the basis of the stable isotope data, consistent with other field, petrographic and geochemical evidence. Cordierite in the cordierite-bearing granites is not “restitic” from a deep source area, but rather is xenocrystic from the high-grade metamorphic country rock (nebulites).
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SINGH, VR, RK LAL, CS CHANOTIYA, SS DHAWAN, PANKHURI GUPTA, NAMITA SINGH, RK UPADHYAY et al. „CIM-Utkrisht: A high essential oil yielding variety of patchouli (Pogostemon cablin (Blanco) Benth) with a unique aroma suitable for cultivation under North Indian conditions“. Journal of Medicinal and Aromatic Plant Sciences 41, Nr. 4 (31.12.2019): 79–85. http://dx.doi.org/10.62029/jmaps.v41i4.singh.

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Patchouli (Pogostemon cablin (Blanco) Benth) is an aromatic bushy herb of the Family- Lamiaceae, commonly called the, “Mint or deadnettle family”. The crop is mainly cultivated for its oil used in the manufacture of perfumes, cosmetics, medicines, beverages and in bakery. The oil is a perfume by itself and is highly valued in perfumes, soaps, cosmetics and flavour industries. It is also used as a scent in products like paper towels, laundry detergents, and air fresheners. The new variety CIM-Utkrisht of Patchouli has been developed by CSIR-CIMAP through intensive breeding efforts for improved herb and essential oil yield coupled with high patchouli alcohol (110 litre oil./ha v/s 56 lit/ha and patchouli alcohol 43 % v/s 41% in the check). The variety has consistently recorded a higher biomass and oil yield with high patchouli alcohol content in the oil in the field evaluation trials. The potential dry leaves yield of this new variety is 63 q/ha and oil yield is 110 Lit/ha. This new variety also satisfies DUS criteria as it is morphologically distinct from other patchouli varieties and clearly identifiable by its broad, big, dark green to light purple leaves with g-curcumene (21-26%) and ar-curcumene (8 %) as unique aromatic constituents in the essential oil.
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LAL, RK, CS CHANOTIYA, AK SHASANY, AK GUPTA, VR SINGH, S. SARKAR, SMITA SINGH et al. „Registration of a high-yielding khusilal [nor-sesquiterpene (C14) aldehydes] rich variety CIM-Samriddhi of vetiver (Chrysopogon zizanioides (L.) Nash.“ Journal of Medicinal and Aromatic Plant Sciences 39, Nr. 4 (31.12.2017): 139–44. http://dx.doi.org/10.62029/jmaps.v39i4.lal4.

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Vetiver (Khus) of the family 'Poaceae' is native to India and is mainly cultivated in tropical and subtropical countries as a perennial crop. It is cultivated for the production of its root derived hydro distilled essential oil that imparts a strong and persistent woody odor. The oil can also have earthy, grapefruit-like, flowery, smoked and ambery, undertones, depending upon the geographic origin of the crop. Vetiver oil is a high value basic ingredient of modern perfumery today. The total world production of this essential oil is estimated to be around 600-700 tonnes per year as compared to only 20-25 tonnes produced annually in India. Therefore, khus cultivation in Indian context is a viable option for increasing farmer's income as its oil demand for perfume and soap industries is constantly rising. However, its long gestation nature and poor oil content have always been a deterring factor for its acceptance among the farmers. Over last 10-15years, CSIR-CIMAP has developed nine khus cultivars for maximizing the benefits of its cultivation to khus growers in different parts of the country. Khus cultivation often results an average net profit of over Rs 1.5 lacs in a span of 10-12 months with 25-30kg/ha oil yield. In addition, co-cultivation of khus with wheat, lentil, peas, mint, basil etc. can further add to the profit margin by Rs. 30, 000/ha. Looking at the huge import requirement of Vetiver oil in the country, the need to enhance the unit area productivity and quality of vetiver oil is evident. Continuing with our effort towards genetic enhancement in vetiver, we have now developed a new genotype, namely V-18(Selection 23) that is capable of producing 35 kg/ha of high grade essential oil in comparisons to 25kg/ha oil yield of best available check ie. CIM-Vriddhi (also developed by CSIR-CIMAP). The new genotype, in addition to improved root biomass 35q/ha and oil yields, also have a much desired quality profile with 31% khushilal and 19% khusol contents in its oil. The new genotype V-18 (selection 23) is ideally suited for its cultivation in entire North-Indian plains and southern region of the country. The unique yellow-green inflorescence and broad dark green leaves are the two unique distinctive features of this variety It also fits in crop rotation/intercropping cycles between mint and paddy and with other vegetables crops grown by farmers with small land holding. Leaves of this variety are nutritive and can be used as fodder for milk producing animals. The new genotype has now been christening as CIM-Samriddhil" and is being registered here as a new improved variety of vetiver for its commercial release.
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Sharma, Ram Suresh, Sanjay Kumar, Deepak Kumar und R. K. Srivastava. „Economic analysis of mint cultivation in Madhepura district of Bihar“. INTERNATIONAL RESEARCH JOURNAL OF AGRICULTURAL ECONOMICS AND STATISTICS 11, Nr. 2 (15.09.2020): 127–31. http://dx.doi.org/10.15740/has/irjaes/11.2/127-131.

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The present study of mint variety-CIM-Karnti demonstrated for cultivation of Madhepura district of Bihar. Mint is an essential oil bearing plant. Oil and its derivatives are extensively used in food, pharmaceutical, perfumery and flavouring industry. During the study period, 55 farmers of mint cultivation have been demonstrated on the farmer’s field of five villages under Madhepura district of Bihar during 2018-19. The primary data were collected from the selected farmer’s field. Simple analytical tools and technique has been used for data analysis and for carried out the cost of cultivation according different cost concepts. The multiple linear production function was used to evaluate the resource use efficiency in the production of mint. It was observed that medium level adoption of mint cultivation has been found higher followed by high and low level adoption. The total cost of cultivation and gross return has been found Rs. 52,804 /- and Rs. 1, 59,268/- ha-1, respectively. The net return on cost A1, C, Rs. 1,06,464/- and Rs. 90,640/-ha-1. The benefit cost ratio has been observed 2.02 and 1.32 at cost A1 and Cost C, respectively. The independent variables like sucker and nursery raising, manures and fertilizers and distillation charges were positive indicating significant impact on the returns from mint crop in the study area. Thus, profitable returns through cultivation of mint may attract large number of farmers to cultivate this crop to enhance their income and employment in the study area with integrated farming traditional crops.
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Devapal, D., S. S. Kumar und R. Sethunadh. „Discontinuity adaptive SAR image despeckling using curvelet-based BM3D technique“. International Journal of Wavelets, Multiresolution and Information Processing 17, Nr. 03 (Mai 2019): 1950016. http://dx.doi.org/10.1142/s0219691319500164.

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Synthetic Aperture Radar (SAR) is an all-weather, day and night satellite imaging technology where the radar is mounted on aircraft and successive pulses of radio waves are transmitted to illuminate the target scene. The signal processing of the recorded backscattered echoes produce SAR images. SAR images contain inherent multiplicative speckle noise which is formed due to the constructive and destructive interference of transmitted signals with the returning signals. Speckle noise appears as granular patterns and makes the image interpretation difficult. Non-local means approaches like Block Matching and 3D filtering (BM3D) are effective scheme for removing speckle noise from SAR images. This method gives good performance for additive noise but is not adaptive to curved edges and discontinuities that occur in SAR images affected by multiplicative noise. This paper proposes a three-step refined algorithm to adapt BM3D for despeckling multiplicative speckle noise. In the proposed scheme curvelet is used to find the transform coefficients and this modification in the transform domain improves the despeckling accuracy of BM3D. Also Wiener filtering is replaced with Importance Sampling Unscented Kalman Filtering (ISUKF) for better adapting to discontinuities in the real SAR image. An improved method of grouping is proposed here based on Manhattan distance which better adapts to constantly changing multiplicative noise statistics. A detailed comparative study is carried out on each step using various well-known performance measures. From the results, it is found that the proposed Curvelet-ISUKF-Manhattan BM3D (CIM-BM3D) method of despeckling has better values for all the performance measure and the results are also visually verified.
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Bose, Subir Kumar, Ravi Prakash Bansal und Neelam S. Sangwan. „DEVELOPMENT OF AN AGRO TECHNIQUE FOR LARGE-SCALE PRODUCTION OF GERANIUM’S PLANTLETS FOR CULTIVATION AND BRINJAL INTERCROPPING“. Journal of Advanced Scientific Research 13, Nr. 09 (31.10.2022): 24–32. http://dx.doi.org/10.55218/jasr.202213905.

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Essential oil-bearing medicinal and aromatic plant Pelargonium graveolense is commonly known as rose-scented geranium because of its characteristic rose like smell. Its essential oil possesses medicinal properties such as insect repellent properties and also used in fragrance and food industry. Its demand is very high because of the above use in India and the worldwide market. This experiment is designed to develop an agro technique method for large scale production of geranium plantlets (cultivar CIM-Pawan) at field conditions using simple stem cutting method at North Indian field conditions in Uttar Pradesh, India. And also introduce a new method of intercropping cultivation of geranium in Brinjal (Solanum melongena) that is developed. This experiment was designed in such a manner to developed thousand plantlets from one year old a single mother plants. As we know near about 30,000 stem cuttings are required for planting an area of one hectare land. So focusing on large demands of plantlets developed an agro technique that is able to fulfil the requirements. The crops were raised using one month olds plantlets transplanting, viz. with intercropping in Brinjal. After harvesting oil was extracted by hydro-distillation using Clevenger apparatus and analyzed by gas chromatography (GC). The Citronellol/Geraniol ratio (C: G), quality determining factor was found to 1.23. The GC and GC-MS analysis results indicated that the essential oil components, quality and quantity were significant. The major constituents of the essential oil were Citronellol (29.81%), Geraniol (24.23%), Linalool (3.12%), Iso-menthone (4.09%), Citronellyl formate (7.51%), Geranyl formate (6.07%), and 10-epi-γ-eudesmol (2.70%).
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Bond, Leila, Gloria Bowen, Benjamin Mertens, Keelie Denson, Kathleen Jordan, Branislav Vidakovic und Cassie S. Mitchell. „Associations of Patient Mood, Modulators of Quality of Life, and Pharmaceuticals with Amyotrophic Lateral Sclerosis Survival Duration“. Behavioral Sciences 10, Nr. 1 (10.01.2020): 33. http://dx.doi.org/10.3390/bs10010033.

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Associations of modulators of quality of life (QoL) and survival duration are assessed in the fatal motor neuron disease, Amyotrophic Lateral Sclerosis. Major categories include clinical impression of mood (CIM); physical health; patient social support; and usage of interventions, pharmaceuticals, and supplements. Associations were assessed at p < 0.05 and p < 0.001 significance thresholds using applicable methods (Chi-square, t-test, ANOVA, logistical regression, random forests, Fisher’s exact test) within a retrospective cohort of 1585 patients. Factors significantly correlated with positive (happy or normal) mood included family support and usage of bi-level positive airway pressure (Bi-PAP) and/or cough assist. Decline in physical factors like presence of dysphagia, drooling, general pain, and decrease in ALSFRS-R total score or forced vital capacity (FVC) significantly correlated with negative (depressed or anxious) mood (p < 0.05). Use of antidepressants or pain medications had no association with ALS patient mood (p > 0.05), but were significantly associated with increased survival (p < 0.05). Positive patient mood, Bi-PAP, cough assist, percutaneous endoscopic gastrostomy (PEG), and accompaniment to clinic visits associated with increased survival duration (p < 0.001). Of the 47 most prevalent pharmaceutical and supplement categories, 17 associated with significant survival duration increases ranging +4.5 to +16.5 months. Tricyclic antidepressants, non-opioids, muscle relaxants, and vitamin E had the highest associative increases in survival duration (p < 0.05). Random forests, which examined complex interactions, identified the following pharmaceuticals and supplements as most predictive to survival duration: Vitamin A, multivitamin, PEG supplements, alternative herbs, antihistamines, muscle relaxants, stimulant laxatives, and antispastics. Statins, metformin, and thiazide diuretics had insignificant associations with decreased survival.
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Baloch, Muhammad Jurial, Rehana Lochi, Wajid Ali Jatoi, Abdul Wahid Baloch und Muhammad Ahmed Arain. „Genetic Variability, Heritability and Correlation Studies in F2 Populations of Upland Cotton“. Biological Sciences - PJSIR 61, Nr. 3 (24.12.2018): 136–44. http://dx.doi.org/10.52763/pjsir.biol.sci.61.3.2018.136.144.

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A field experiment was conducted at the experimental area of the Department of Plant Breeding & Genetics, Sindh Agriculture University Tandojam, during the year 2014-2015 in order to carry-out genetic analysis in F2 populations of upland cotton. The trial was laid-out in a Randomized Complete Block Design with four replications. The material was consisted of eight parents and ten F2 populations. The analysis of variance revealed significant differences among the parents and F2 populations for all the traits studied except that fibre length was non-significant in parents. The results further suggested that maximum heritability, higher genetic variances coupled with more genetic gains were expressed by the F2 populations CRIS-134 ´ CRIS-508 and CRIS-134 ´ CIM-598 for 1st sympodial node number; CRIS-134 ´ Neelum- 121 and CRIS-134 ´ CRIS-508 for sympodial branches/plant; CRIS-342 ´ FH-113 for boll weight; CRIS- 342 ´ Neelum-121 for bolls/plant, seed cotton yield/plant, lint % and micronaire value and progenies CRIS-342 ´ MNH-886 followed by CRIS-342 ´ Neelum-121 for staple length. These results also suggested that a number of F2 populations indicated their potential for various seed cotton yield and fibre traits. The phenotypic correlations revealed that most of the traits were significantly and positively associated with seed cotton yield/plant. However, higher correlations of sympodial branches/plant (r = 0.69**) and bolls/ plant (r = 0.82**) with seed cotton yield indicated that both the traits are more reliable as compared to other traits for selection of higher seed cotton yields. Very interestingly, fibre traits like lint%, fibre length and micronaire were also significantly correlated with seed cotton yield, suggesting that fibre quality traits can be improved without compromising on seed cotton yield. Thus, the material under study is very promising and worthy of selection to improve many traits simultaneously.
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Hameed, R. A., S. Ajum und M. N. Afzal. „Effect of Glyphosat and Paraquat Herbicides on Weed Control and Productivity of Cotton“. Cercetari Agronomice in Moldova 50, Nr. 2 (01.06.2017): 51–56. http://dx.doi.org/10.1515/cerce-2017-0014.

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AbstractWeed control management has a vital role in increasing cotton yield and yield components. In cotton crop weed, infestation may harm significant growth and yield loses. To control the weeds under field conditions in cotton crop, different herbicides were selected with different dose levels. Response of various post emergence herbicides at different levels, i.e. Round up 490 G/L at the rate of 4.7 L ha−1, 2.7 L ha−1and 1.5 L ha−1(Glyphosate), Gramoxone 20EC (Paraquat) at the rate of 2.5 L ha−1and untreated (Control) were field experimented against cotton cultivar CIM-473 under field condition at Agronomic Research Area of Central Cotton Research Institute (CCRI) Multan, Pakistan. Significant control of weeds, i.e. number of weeds m−2, fresh weed biomass in g m−2, dry weed biomass in g m−2and increase in yield and yield contributing factors, like number of bolls plant−1, cotton boll weight (g), final cotton plant height (cm) and seed cotton yield (kg ha−1) were observed. The field data for weed control in term of numbers, fresh and dry weight was observed after 10, 20 and 30 days of sowing. It was indicated that the highest significant yield, total number of bolls per plant, fresh weed biomass, dry weed biomass, plant height and weed control were obtained by using herbicide Round up (Glyphosate) at the rate of 4.7 L ha−1, as compared to the other treatments with different application rates including untreated (control). Average boll weight was not significant among treatments, but significant against control. Cost benefit analysis showed that the highest net profit was obtained by the Round up 490 G/L, when treated @ 4.7 L ha−1than all other treatments.
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Aderonmu, T. S., Omeodu B., M. D. und A. F. Opuende. „Improving Secondary School Physics Students’ Computational Dexterity using the Means-End Analysis (MEA) Approach in Solving Problems in Projectile Motion“. International Journal of Education and Evaluation 8, Nr. 6 (24.08.2023): 43–56. http://dx.doi.org/10.56201/ijee.v8.no6.2022.pg43.56.

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The study was aimed at improving secondary school Physics students’ computational dexterity using the Means-End Analysis (MEA) in solving problems in projectile motion. Two research questions were raised and answered while two hypotheses were formulated and tested. Quasi- experimental design specifically, the pre-test, post-test experimental and control group method was adopted for the study. Using the purposive sampling technique, 93 SS2 Physics students were selected in public secondary schools in Port Harcourt Local Government Area, Rivers State. Data collecting instrument was Projectile Motion Performance Test with a reliability index of r = 0.78. Data obtained for the study were analyzed using mean and standard deviation while while Analysis of Covariance and Scheff’s Post Hoc analysis was used to test the hypotheses at 0.05 level of significance. The findings of the study revealed that there was better improvement of students’ computational dexterity when solving problems in projectile using the Means-End Analysis than the Conventional Instructional Method. This is also evident by the Ho 1 , F (1,90) = 124.483 and p = 0.00 < ? = 0.05. The study also indicated that male students improved in their computational dexterity in projectile motion than their female counterparts across both groups employed for the study, while Ho 2 showed that there is no significant difference between male and female students mean performance scores exposed to Means-End Analysis (MEA) approach and Conventional Instructional Method (CIM) in improving students’ computational dexterity in solving problems in projectile motion in Physics [F (1,88) = 0.035 and p = 0.851 > ? = 0.05]. The study recommends that Physics teachers in secondary schools should adopt the Mean-End Analysis approach especially during teaching of topics that are mathematical (like projectile motion) so that students’ computational dexterity will be improved.
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Kwon, Deukwoo, Steven L. Simon, F. Owen Hoffman und Ruth M. Pfeiffer. „Frequentist model averaging for analysis of dose–response in epidemiologic studies with complex exposure uncertainty“. PLOS ONE 18, Nr. 12 (14.12.2023): e0290498. http://dx.doi.org/10.1371/journal.pone.0290498.

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In epidemiologic studies, association estimates of an exposure with disease outcomes are often biased when the uncertainties of exposure are ignored. Consequently, corresponding confidence intervals (CIs) will not have correct coverage. This issue is particularly problematic when exposures must be reconstructed from physical measurements, for example, for environmental or occupational radiation doses that were received by a study population for which radiation doses cannot be measured directly. To incorporate complex uncertainties in reconstructed exposures, the two-dimensional Monte Carlo (2DMC) dose estimation method has been proposed and used in various dose reconstruction efforts. The 2DMC method generates multiple exposure realizations from dosimetry models that incorporate various sources of errors to reflect the uncertainty of the dose distribution as well as the uncertainties in individual doses in the exposed population. Traditional measurement-error model approaches, typically based on using mean doses in the dose-exposure analysis, do not fully account exposure uncertainties. A recently developed statistical approach that overcomes many of these limitations by analyzing multiple exposure realizations in relation to disease risk is Bayesian model averaging (BMA). The analytic advantage of the BMA is its ability to better accommodate complex exposure uncertainty in the risk estimation, but a practical. Drawback is its significant computational complexity. In this present paper, we propose a novel frequentist model averaging (FMA) approach which has all the analytical advantages of the BMA method but is much simpler to implement and computationally faster. We show in simulations that, like BMA, FMA yields 95% confidence intervals for association parameters that close to 95% coverage rate. In simulations, the FMA has shorter length of CIs than those of another frequentist approach, the corrected information matrix (CIM) method. We illustrate the similarities in performance of BMA and FMA from a study of exposures from radioactive fallout in Kazakhstan.
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Anderson, DT, und JT Anderson. „Functional morphology of the balanomorph barnacles Tesseropora rosea (Krauss) and Tetraclitella purpurascens (Wood) (Tetraclitidae)“. Marine and Freshwater Research 36, Nr. 1 (1985): 87. http://dx.doi.org/10.1071/mf9850087.

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Tesseropora rosea of eastern Australia inhabits exposed, wave-washed rocks, is an extension feeder in fast currents, and has monometric growth, with orifice enlargement by erosion. It has a deep, mobile operculum. Tergal depressor muscles are large, scutal depressors moderately large. The opercular valves play an active part in respiratory pumping beat. Tergal depressors effect opercular withdrawal. Rostral scutal depressors assist in pumping beat. Lateral scutal depressors assist in opercular opening. Cim IV-VI of T. rosea unfurl rapidly in response to fast water currents and are captorial, either singly or in concert. The antenniform third maxillipeds (cirrus 111) turn back laterally in the extended position but fold over and hold down the captorial cirri in the curled position. Tetraclitella purpurascens of southern Australia inhabits crevices and overhangs on rocky shores, is an extension feeder in moderate currents, and has diametric growth, with orifice enlargement by circumferential growth of radii and parietes. It has a shallow operculum with only slight mobility. Tergal depressors are large, scutal depressors small. Valve action is mainly hinge-like and slow, with little apicobasal movement. The small scutal depressors assist the large tergal depressors in opercular withdrawal and have only a very minor role in pumping beat. Cirri IV-VI of T. purpurascens are held erect for long periods in moderate water currents. Captorial movements are similar to but slower than those of T. rosea. The third maxillipeds have short rami involved in forward food transfer. Setation correlates with function on the cirri of both species. The oral cone of T. rosea is broader and the mouthparts relatively larger than those of T. purpurascens, possibly mediating a more powerful triturating mechanism. A comparison of structure and function shows that T. purpurascens retains many primitive balanomorph features, whereas T. rosea has a more advanced functional configuration. In the evolution of tetraclitids, it seems likely that the tetraclitellines diverged early, before the austrobalanines gave rise to the tetraclitines. The four-plated wall may have evolved independently in tetraclitellines and austrobalanines.
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Lee, Heon-Jeong. „Can’t Humans Live According to the Sun, Not the Clock, Like Other Creatures on Earth?“ Chronobiology in Medicine 3, Nr. 4 (31.12.2021): 127–28. http://dx.doi.org/10.33069/cim.2021.0027.

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47

Fedele, Renato, Fatema Tanjia, Dusan Jovanović, Sergio De Nicola und Concetta Ronsivalle. „Wave theories of non-laminar charged particle beams: from quantum to thermal regime“. Journal of Plasma Physics 80, Nr. 2 (15.01.2014): 133–45. http://dx.doi.org/10.1017/s0022377813000913.

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AbstractThe standard classical description of non-laminar charged particle beams in paraxial approximation is extended to the context of two wave theories. The first theory that we discuss (Fedele R. and Shukla, P. K. 1992 Phys. Rev. A45, 4045. Tanjia, F. et al. 2011 Proceedings of the 38th EPS Conference on Plasma Physics, Vol. 35G. Strasbourg, France: European Physical Society) is based on the Thermal Wave Model (TWM) (Fedele, R. and Miele, G. 1991 Nuovo Cim. D13, 1527.) that interprets the paraxial thermal spreading of beam particles as the analog of quantum diffraction. The other theory is based on a recently developed model (Fedele, R. et al. 2012a Phys. Plasmas19, 102106; Fedele, R. et al. 2012b AIP Conf. Proc.1421, 212), hereafter called Quantum Wave Model (QWM), that takes into account the individual quantum nature of single beam particle (uncertainty principle and spin) and provides collective description of beam transport in the presence of quantum paraxial diffraction. Both in quantum and quantum-like regimes, the beam transport is governed by a 2D non-local Schrödinger equation, with self-interaction coming from the nonlinear charge- and current-densities. An envelope equation of the Ermakov–Pinney type, which includes collective effects, is derived for both TWM and QWM regimes. In TWM, such description recovers the well-known Sacherer's equation (Sacherer, F. J. 1971 IEEE Trans. Nucl. Sci.NS-18, 1105). Conversely, in the quantum regime and in Hartree's mean field approximation, one recovers the evolution equation for a single-particle spot size, i.e. for a single quantum ray spot in the transverse plane (Compton regime). We demonstrate that such quantum evolution equation contains the same information as the evolution equation for the beam spot size that describes the beam as a whole. This is done heuristically by defining the lowest QWM state accessible by a system of non-overlapping fermions. The latter are associated with temperature values that are sufficiently low to make the single-particle quantum effects visible on the beam scale, but sufficiently high to make the overlapping of the single-particle wave functions negligible. This lowest QWM state constitutes the border between the fundamental single-particle Compton regime and the collective quantum and thermal regimes at larger (nano- to micro-) scales. Comparing it with the beam parameters in the existing accelerators, we find that it is feasible to achieve nano-sized beams in advanced compact machines.
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Rupesh, Kattamreddy Ananth, Mopuri Venkateswarlu, Suresh Pamujula, Pravin Panditrao Kalyankar, Nitesh Motiram Salvi und Shayali Vora. „A Study on Chronofatality Trends of COVID-19 Deaths at a Tertiary Care Hospital“. Chronobiology in Medicine 3, Nr. 4 (31.12.2021): 163–66. http://dx.doi.org/10.33069/cim.2021.0024.

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The aim of the study is to find out any association between time of death in coronavirus disease (COVID-19) patients and variables like age, sex, and existence of comorbidities including type II diabetes mellitus, hypertension, coronary artery disease, chronic kidney disease, etc. An attempt was also made to elucidate the reasons for relationship between time of death and other aforementioned variables. Mortality data of 1,553 COVID-19 cases from a tertiary care hospital between March 2020 to September 2021 were analyzed. Maximum deaths occurred between 18:01 hours to 06:00 hours of the 24-hour cycle. There is a significant statistical association between time of death and age, time of death and sex, time of death and having a comorbidity of diabetes mellitus in the study sample. The study confirms that the chronofatality of COVID-19 deaths has a nocturnal predilection. The circadian rhythms of glucocorticoids, respiratory physiology of sleep, and circadian hemodynamic variations may have a role in prognosis and fatality of COVID-19.
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Alam, Mudassir, Kashif Abbas, Yusra Sharf und Sarfaraz Khan. „Impacts of Blue Light Exposure From Electronic Devices on Circadian Rhythm and Sleep Disruption in Adolescent and Young Adult Students“. Chronobiology in Medicine 6, Nr. 1 (31.03.2024): 10–14. http://dx.doi.org/10.33069/cim.2024.0004.

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The excessive exposure of blue light, originated from electronic gadgets like smartphones, laptops, and tablets, may contribute to sleep problems. Long exposure to blue-wavelength light from these devices affects sleep by suppressing melatonin hormone and cause neurophysiologic consequences. This literature review highlights the most recent findings on the relationship between sleep disruption and blue light exposure among the high school and college student population. A variety of scientific studies have shown that blue light exposure, especially before bedtime, can create circadian disruptions and inhibit melatonin secretion in brain, which ultimately result in deteriorated sleep quality and duration. Sleep deprivation in duration and quality of sleep is reflected in negative effects on mood, learning memory, and academic performance of a student from middle school to college. In general, the accumulating evidence indicates that, to promote adolescent and young adult health, it is necessary to pay attention to the impacts of blue light exposure from modern technologies.
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Kim, Eun Hye, Chan Seok Youn, You Jin Nam, Sunhwa Hong, Yong Hyuk Cho, Sang Joon Son, Chang Hyung Hong und Hyun Woong Roh. „Neuroarchitecture From the Perspective of Circadian Rhythm, Physical, and Mental Health“. Chronobiology in Medicine 5, Nr. 1 (31.03.2023): 3–6. http://dx.doi.org/10.33069/cim.2023.0005.

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The field of neuroarchitecture explores how various architectural elements impact human physical and mental health, based on neuroscience principles. With the development of functional neuroimaging and electroencephalogram studies, researchers can now visualize and quantify how different architectural factors affect brain activity, emotions, and cognition. Mobile Brain/Body Imaging is a new research methodology that records a moving person’s brain activity and bodily sensations in real time, promising to be a useful tool for space and urban design. In this article, we discuss neuroarchitecture from the perspective of circadian rhythm, physical health, and mental health. Studies have shown that artificial light at night disrupts the circadian rhythm, leading to acute and chronic negative health effects. Conversely, creating a personcentered light environment or incorporating nature-like elements can have a positive impact on health. Research has also shown that exposure to nature reduces self-rumination and contributes to psychological well-being. Neuroarchitecture studies on other factors, such as ceiling height, wall colors, and the movement of people in the building, should be expanded to gain greater insights and practical applications. The convergence of neuroscience and architecture has the potential to identify architectural elements that benefit human physical and mental health.

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