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Pasquini, Luca, Antonio Napolitano, Emanuela Tagliente, Francesco Dellepiane, Martina Lucignani, Antonello Vidiri, Giulio Ranazzi et al. „Deep Learning Can Differentiate IDH-Mutant from IDH-Wild GBM“. Journal of Personalized Medicine 11, Nr. 4 (09.04.2021): 290. http://dx.doi.org/10.3390/jpm11040290.
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Isocitrate dehydrogenase (IDH) mutant and wildtype glioblastoma multiforme (GBM) often show overlapping features on magnetic resonance imaging (MRI), representing a diagnostic challenge. Deep learning showed promising results for IDH identification in mixed low/high grade glioma populations; however, a GBM-specific model is still lacking in the literature. Our aim was to develop a GBM-tailored deep-learning model for IDH prediction by applying convoluted neural networks (CNN) on multiparametric MRI. We selected 100 adult patients with pathologically demonstrated WHO grade IV gliomas and IDH testing. MRI sequences included: MPRAGE, T1, T2, FLAIR, rCBV and ADC. The model consisted of a 4-block 2D CNN, applied to each MRI sequence. Probability of IDH mutation was obtained from the last dense layer of a softmax activation function. Model performance was evaluated in the test cohort considering categorical cross-entropy loss (CCEL) and accuracy. Calculated performance was: rCBV (accuracy 83%, CCEL 0.64), T1 (accuracy 77%, CCEL 1.4), FLAIR (accuracy 77%, CCEL 1.98), T2 (accuracy 67%, CCEL 2.41), MPRAGE (accuracy 66%, CCEL 2.55). Lower performance was achieved on ADC maps. We present a GBM-specific deep-learning model for IDH mutation prediction, with a maximal accuracy of 83% on rCBV maps. Highest predictivity achieved on perfusion images possibly reflects the known link between IDH and neoangiogenesis through the hypoxia inducible factor.
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Gross, Jeffrey B. „CCEL Anesthesia featuring Anesthesia Fourth Edition“. Anesthesiology 83, Nr. 6 (01.12.1995): 1389–90. http://dx.doi.org/10.1097/00000542-199512000-00055.
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Sun, Qiao-yan, Xue-jiao Liu, Yu-mei Sun, Mei-chun Wang, Xiang Han und Xiang-guang Chen. „A Security Wireless Monitoring and Automatic Protection System for CCEL“. Wireless Communications and Mobile Computing 2021 (14.05.2021): 1–14. http://dx.doi.org/10.1155/2021/6652246.
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A wireless monitoring and automatic protection system for laboratory safety is proposed to solve the security problems in chemistry and chemical engineering laboratories (CCEL). The system is based on a wireless sensor network (WSN), including indoor wireless security monitoring node, information aggregation and management node, portable handheld terminal, and laboratory security information management system. Each indoor safety wireless monitoring node can monitor the laboratory security information (for example, fire information, toxic gas content, abnormal sound in chemistry, and chemical engineering laboratory) and control the corresponding protection device. The portable handheld terminal can remind the safety responsible person to check the safety status of the laboratory remotely and can issue corresponding operation and control instructions. According to the instructions it sends, the indoor security wireless monitoring and control node can start the corresponding automatic protection device. The experimental results demonstrate that the system can realize all-weather online monitoring of indoor safety information, ensuring that some important scientific research experiments can be conducted continuously and safely, significantly reduced the workload of laboratory managers, and precisely reported the location and conditions of accidents; the loss caused by the accident can be minimized based on the automatic protection device. The system can also be used in dangerous goods warehouse and inflammable and explosive places.
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Castillo, Hermínia Vincentelli de, und Jeanette Lejter de Bascones. „Perfil do comportamento de leitura de alunos da 6ª série de escola do 1° grau segundo suas condições sociais“. Psicologia Escolar e Educacional 1, Nr. 2-3 (1997): 39–49. http://dx.doi.org/10.1590/s1413-85571997000100005.
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O presente estudo teve como objetivo caracterizar o comportamento de les de 295 estudantes do 6° ano da Escola Básica de instituições públicas e particulares em função do nível social. Para a obtenção da informação foram aplicados dois instrumentos: questionário para a caracterização do comportamento de ler (CCEL) e Medida de Entusiasmo frente a Leitura (MEL). Os resultados indicam que o perfil leitor da amostra varia segundo a camada social da qual são provenientes os sujeitos. Não obstante foram observados comportamentos semelhantes entre os sujeitos das três camadas sociais estudadas.
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Shedrow, Stephanie J. „Cross-Cultural Student Teaching: Examining the Meaning-Making of one White, Female, MiddleClass Preservice Teacher“. Journal of International Students 7, Nr. 2 (01.04.2017): 270–90. http://dx.doi.org/10.32674/jis.v7i2.381.
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While teacher educators implement diverse student teaching placements for preservice teachers as a means of bridging the cultural mismatch in classrooms around the United States, researchers have only recently begun to tap into the role that preservice teachers’ “whiteness” plays in their ideologies. As such, the purpose of this study was to better understand how one white, female preservice teacher made meaning of her experiences during a cross-cultural experiential learning (CCEL) student teaching placement abroad. Analyzing if and how previous intercultural interactions were drawn upon while abroad, as well as how experiences abroad were employed once returning to the US, findings suggest that cultural competency does not directly equate to recognizing whiteness and the privileges associated.
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Ning, Huiping. „The impact of cooperative learning on English as a foreign language tertiary learners' social skills“. Social Behavior and Personality: an international journal 41, Nr. 4 (01.05.2013): 557–67. http://dx.doi.org/10.2224/sbp.2013.41.4.557.
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In this study, I focused on the impact of cooperative learning on the development of social skills in English as a foreign language (EFL) tertiary students. Participants were 2 randomly selected classes of students from a university in the north of China. A pretest-posttest control group quasiexperimental design was employed for the comparison of the impact of the cooperative learning approach with that of traditional whole-class instruction on 8 aspects of social skills: self-confidence, sense of cohesion, initiative in socialization, being positive, checking for understanding, equal participation and accountability, acceptance and empathy, and conflict management. These aspects form 8 subscales of the Social Skills Scale for Chinese College English Learners (SSS-CCEL; Ning, 2010), which the participants completed. Findings suggest substantial differences in favor of cooperative learning in the improvement of students' overall social skills, and in particular in the skills of equal participation and accountability.
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Pan, Chun-Hsu, Yu-Pei Lin, Jie-Yu Wang, Hui-Yu Huang, Shun-Cheng Huang, Ji-Mehng Lo und Chieh-Hsi Wu. „Preventive Effect and Mechanism of Crossostephium chinense Extract on Balloon Angioplasty-Induced Neointimal Hyperplasia“. Evidence-Based Complementary and Alternative Medicine 2021 (30.06.2021): 1–11. http://dx.doi.org/10.1155/2021/8466543.
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Balloon angioplasty-induced neointimal hyperplasia remains a clinical problem that must be resolved. The bioactivities of the Crossostephium chinense extract (CCE) have demonstrated potential in preventing the progression of restenosis. The present study evaluated whether CCE can suppress balloon angioplasty-induced neointima formation and elucidated its possible pharmacological mechanisms. A rat model of carotid arterial balloon angioplasty was established to evaluate the inhibitory effect of CCEs on neointimal hyperplasia. Two cell lines, A10 vascular smooth muscle cells (VSMCs) and RAW264.7 macrophages, were used to investigate the potential regulatory activities and pharmacological mechanisms of CCEs in cell proliferation and migration and in inflammation. Our in vitro results indicated that CCE3, the ethanolic extract of C. chinense, exerted the strongest growth inhibitory and antimigratory effects on VSMCs. CCE3 blocked the activation of focal adhesion kinase, platelet-derived growth factor receptor-β (PDGFRB), and its downstream molecules (AKT and mTOR) and reduced the expression of matrix metalloproteinase-2. In addition, our findings revealed that CCE3 significantly increased the expression of miRNA-132, an inhibitory regulator of inflammation and restenosis, and suppressed the expression of inflammation-related molecules (inducible nitric oxide synthase, cyclooxygenase-2, interleukin- (IL-) 1β, and IL-6). Our in vivo study results indicated that balloon injury-induced neointimal hyperplasia was inhibited by CCE3. CCE3 could reduce neointima formation in balloon-injured arteries, and this effect may be partially attributed to the CCE3-induced suppression of PDGFRB-mediated downstream pathways and inflammation-related molecules.
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Zhou, Da-Kai, Xi-Wang Yang, Huining Li, Yongbo Yang, Zhen-Jun Zhu und Na Wu. „Up-Regulation of Long Noncoding RNA CCAL Predicts Poor Patient Prognosis and Promotes Tumor Metastasis in Osteosarcoma“. International Journal of Biological Markers 32, Nr. 1 (Januar 2017): 108–12. http://dx.doi.org/10.5301/jbm.5000240.
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Background Long noncoding RNAs (IncRNAs) play essential roles in tumor progression. Aberrant colorectal cancer-associated IncRNA (CCAL) has been found in colorectal cancer. However, the function of IncRNA CCAL in osteosarcoma (OS) remains unclear. Methods Quantitative real-time PCR (qRT-PCR) was performed to measure CCAL expression in OS tissues and adjacent nontumor tissues. The correlation betweent CCAL expression and clinicopathological features and prognosis was also analyzed. In addition, the function of CCAL was further evaluated by cell proliferation, migration and invasion assays. Results We showed that CCAL was significantly up-regulated in OS tissues compared with adjacent nontumor tissues. Increased expression of CCAL was correlated with advanced TNM stage and metastasis. Kaplan-Meier analysis demonstrated that patients with high CCAL expression had lower overall survival than those with low CCAL expression. Multivariate Cox regression analysis indicated that CCAL expression might be an independent prognostic factor for OS patients. In addition, functional assays showed that decreased CCAL expression could inhibit OS cell proliferation, migration and invasion ability. Conclusions Our findings suggested that CCAL plays critical roles in OS progression and could act as a therapeutic target in the treatment of OS.
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Silveira, Éricka Janine Dantas da, Márcio Campos Oliveira, Maria de Lourdes Silva Arruda de Morais, Lélia Maria Guedes Queiroz und Antonio de Lisboa Lopes Costa. „Expressão da proteína nm23 em carcinoma de células escamosas de língua metastático e não-metastático“. Revista Brasileira de Otorrinolaringologia 74, Nr. 3 (Juni 2008): 356–59. http://dx.doi.org/10.1590/s0034-72992008000300008.
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O carcinoma de células escamosas oral (CCEO) exibe prognóstico desfavorável em decorrência da capacidade de invasão aos tecidos vizinhos e elevada incidência de metástases. OBJETIVO: O presente trabalho objetiva analisar a expressão imunohistoquímica da proteína nm23 em CCEs de língua metastáticos e não-metastáticos. METODOLOGIA: A técnica da imunohistoquímica para a proteína nm23-h1 foi realizada em 35 casos de CCE de língua com metástase em 15 casos. Atribuiu-se escore 0, para ausência de marcação; 1, marcação focal e 2 para marcação difusa. RESULTADOS: Observou-se marcação focal para a proteína nm23 em 9 casos, difusa em 15, e ausência de marcação em 11 espécimes. O teste exato de Fischer foi aplicado, não havendo diferença estatisticamente significativa para positividade desta proteína nos casos metastáticos e não-metastáticos (p=0.365), apesar de que em 66.7% dos casos com metástase não houve marcação. CONCLUSÕES: A presença da proteína nm23 não esteve relacionada de forma positiva aos casos de CCE de língua sem metástase. Dessa forma, vários outros fatores inerentes à célula neoplásica e ao hospedeiro podem estar relacionados aos mecanismos supressores do processo metastático nesta entidade.
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LEITE, CAROLINE JUNQUEIRA BARCELLOS, JOSSANA PEREIRA de SOUSA, JOSÉ ALBERTO da COSTA MEDEIROS, MARIA LÚCIA da CONCEIÇÃO, VIVYANNE dos SANTOS FALCÃO-SILVA und EVANDRO LEITE de SOUZA. „Inactivation of Escherichia coli, Listeria monocytogenes, and Salmonella Enteritidis by Cymbopogon citratus D.C. Stapf. Essential Oil in Pineapple Juice“. Journal of Food Protection 79, Nr. 2 (01.02.2016): 213–19. http://dx.doi.org/10.4315/0362-028x.jfp-15-245.
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ABSTRACTIn the present study, the efficacy of Cymbopogon citratus D.C. Stapf. essential oil (CCEO) to provoke a 5-log CFU/ml (5-log) inactivation in a mixed composite of Escherichia coli, Listeria monocytogenes, and Salmonella enterica serovar Enteritidis in pineapple (Ananas comosus (L.) Merril) juice (4°C) was assessed. Moreover, the effects of CCEO on the physicochemical and sensory quality parameters of pineapple juice were evaluated. The MIC of CCEO was 5 μl/ml against the composite mix examined. For L. monocytogenes and E. coli inoculated in juice containing CCEO (5, 2.5, and 1.25 μl/ml), a ≥5-log reduction was detected after 15 min of exposure. This same result was obtained for Salmonella Enteritidis incubated alone in pineapple juice containing CCEO at 5 and 2.5 μl/ml. Overall, Salmonella Enteritidis was the most tolerant and L. monocytogenes was the most sensitive to CCEO. The physicochemical properties (pH, titratable acidic [citric acid per 100 g], and soluble solids) of pineapple juice containing CCEO (2.5 and 1.25 μl/ml) were maintained. Juice containing CCEO (2.5 and 1.25 μl/ml) exhibited similar scores for odor, appearance, and viscosity compared with juice without CCEO. However, unsatisfactory changes in taste and aftertaste were observed in juices containing CCEO. These results suggest that CCEO could be used as an alternative antimicrobial compound to ensure the safety of pineapple juice, although CCEO at the tested concentrations negatively impacted its taste. Therefore, further studies are needed to determine the balance between microbial safety and taste acceptability of pineapple juice containing CCEO.
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Jenks, Scott A., Chungwen Wei, Regina Bugrovsky, Aisha Hill, Xiaoqian Wang, Francesca M. Rossi, Kevin Cashman et al. „B cell subset composition segments clinically and serologically distinct groups in chronic cutaneous lupus erythematosus“. Annals of the Rheumatic Diseases 80, Nr. 9 (03.06.2021): 1190–200. http://dx.doi.org/10.1136/annrheumdis-2021-220349.
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ObjectiveWhile the contribution of B-cells to SLE is well established, its role in chronic cutaneous lupus erythematosus (CCLE) remains unclear. Here, we compare B-cell and serum auto-antibody profiles between patients with systemic lupus erythematosus (SLE), CCLE, and overlap conditions.MethodsB-cells were compared by flow cytometry amongst healthy controls, CCLE without systemic lupus (CCLE+/SLE−) and SLE patients with (SLE+/CCLE+) or without CCLE (SLE+/CCLE−). Serum was analyed for autoreactive 9G4+, anti-double-stranded DNA, anti-chromatin and anti-RNA antibodies by ELISA and for anti-RNA binding proteins (RBP) by luciferase immunoprecipitation.ResultsPatients with CCLE+/SLE− share B-cell abnormalities with SLE including decreased unswitched memory and increased effector B-cells albeit at a lower level than SLE patients. Similarly, both SLE and CCLE+/SLE- patients have elevated 9G4+ IgG autoantibodies despite lower levels of anti-nucleic acid and anti-RBP antibodies in CCLE+/SLE−. CCLE+/SLE− patients could be stratified into those with SLE-like B-cell profiles and a separate group with normal B-cell profiles. The former group was more serologically active and more likely to have disseminated skin lesions.ConclusionCCLE displays perturbations in B-cell homeostasis and partial B-cell tolerance breakdown. Our study demonstrates that this entity is immunologically heterogeneous and includes a disease segment whose B-cell compartment resembles SLE and is clinically associated with enhanced serological activity and more extensive skin disease. This picture suggests that SLE-like B-cell changes in primary CCLE may help identify patients at risk for subsequent development of SLE. B-cell profiling in CCLE might also indentify candidates who would benefit from B-cell targeted therapies.
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Enatsu, Rei, Jorge Gonzalez-Martinez, Juan Bulacio, John C. Mosher, Richard C. Burgess, Imad Najm und Dileep R. Nair. „Connectivity of the frontal and anterior insular network: a cortico-cortical evoked potential study“. Journal of Neurosurgery 125, Nr. 1 (Juli 2016): 90–101. http://dx.doi.org/10.3171/2015.6.jns15622.
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OBJECT The frontal and insular fiber network in humans remains largely unknown. This study investigated the connectivity of the frontal and anterior insular network in humans using cortico-cortical evoked potential (CCEP). METHODS This retrospective analysis included 18 patients with medically intractable focal epilepsy who underwent stereoelectroencephalography and CCEP. Alternating 1-Hz electrical stimuli were delivered to parts of the frontal lobe and anterior insula (prefrontal cortex [PFC], ventrolateral and dorsolateral premotor area [vPM and dPM, respectively], presupplementary motor area [pre-SMA], SMA, frontal operculum, and anterior insula). A total of 40–60 stimuli were averaged in each trial to obtain CCEP responses. The distribution of CCEP was evaluated by calculating the root mean square of CCEP responses. RESULTS Stimulation of the PFC elicited prominent CCEP responses in the medial PFC and PMs over the ipsilateral hemisphere. Stimulation of the vPM and dPM induced CCEP responses in the ipsilateral frontoparietal areas. Stimulation of the pre-SMA induced CCEP responses in the ipsilateral medial and lateral frontal areas and contralateral pre-SMA, whereas stimulation of the SMA induced CCEP responses in the bilateral frontoparietal areas. Stimulation of the frontal operculum induced CCEP responses in the ipsilateral insula and temporal operculum. CCEPs were observed in the ipsilateral medial, lateral frontal, and frontotemporal operculum in the anterior insular stimulation. Stimulation of the vPM and SMA led to the network in the dominant hemisphere being more developed. CONCLUSIONS Various regions within the frontal lobe and anterior insula were linked to specific ipsilateral and contralateral regions, which may reflect distinct functional roles.
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Nurhayati, Betty, Ira Gustira Rahayu, Sonny Feisal Rinaldi, Wawan Sofwan Zaini, Ervi Afifah, Seila Arumwardana, Hanna Sari Widya Kusuma, Rizal Rizal und Wahyu Widowati. „The Antioxidant and Cytotoxic Effects of Cosmos caudatus Ethanolic Extract on Cervical Cancer“. Indonesian Biomedical Journal 10, Nr. 3 (28.12.2018): 243–9. http://dx.doi.org/10.18585/inabj.v10i3.441.
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BACKGROUND: Oxidative stress is closely related to all aspects of cancer. Cosmos caudatus ethanolic extract (CCEE) has been proved to have antioxidant effect that inhibited cancer cell growth due to its bioactive compounds such as catechin, quercetin and chlorogenic acid. This study aimed to evaluate antioxidant and anticancer activity of CCEE and its compounds.METHODS: Total phenol was measured according to the Folin-Ciocalteu method. Catechin, quercetin and chlorogenic acid contained in CCEE were identified by high-performance liquid chromatography (HPLC). Antioxidant activity was evaluated by 2,2′-azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS)-reducing activity, 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging activity, and ferric reducing antioxidant power (FRAP) activity test. The cytotoxic activity of CCEE was determined by MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium] assay on HeLa cells.RESULTS: The result showed that total phenol of CCEE was 181.64±0.93 µg Cathecin/mg extract. ABTSreducing activity test showed that catechin had the highest activity (2.90±0.04 µg/mL), while CCEE had moderate activity compared to other compounds. FRAP activity test demonstrated that catechin had the highest activity (315.83 µM Fe(II)/µg) compared to other compounds. DPPH scavenging activity of CCEE was 22.82±0.05 µg/mL. Cytotoxicity test on HeLa cell showed that CCEE had lower activity (inhibitory concentration (IC)50= 89.90±1.30 µg/mL) compared to quercetin (IC50 = 13.30±0.64 µg/ mL).CONCLUSION: CCEE has the lowest antioxidant activity compared to quercetin, catechin, and chlorogenic acid and has the lowest anticancer activity compared to quercetin. However, CCEE and its compounds has potential as antioxidant and anticancer properties.KEYWORDS: antioxidant, anticancer, catechin, Cosmos caudatus, quercetin
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Ye, Ying, Yanan Song, Juhua Zhuang, Saifei He, Jing Ni und Wei Xia. „Long Noncoding RNA CCAL Promotes Papillary Thyroid Cancer Progression by Activation of NOTCH1 Pathway“. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 26, Nr. 9 (17.10.2018): 1383–90. http://dx.doi.org/10.3727/096504018x15188340975709.
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Long noncoding RNA CCAL has been reported to promote tumor progression in various human cancers, including hepatocellular carcinoma, osteosarcoma, and colorectal cancer. However, the role of CCAL in papillary thyroid cancer remains largely unknown. In the present study, we found that the expression of CCAL was upregulated in papillary thyroid tumor tissues compared to adjacent normal tissues. Moreover, the expression of CCAL was positively related with papillary thyroid cancer severity and TNM stage and predicated poor prognosis. Besides, we found that knockdown of CCAL significantly inhibited papillary thyroid cancer cell proliferation, migration, and invasion in vitro and reduced tumor growth and metastasis in vivo. We found that knockdown of CCAL dramatically decreased the expression of NOTCH1 and suppressed the activation of the NOTCH1 signaling pathway. Furthermore, overexpression of NOTCH1 rescued the proliferation, migration, and invasion in papillary thyroid cancer cells. Taken together, our data indicated that CCAL promoted papillary thyroid cancer development and progression by activation of the NOTCH1 pathway, which provided a new insight on the design of therapeutic targets.
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Terrier, Lénaïc, Alexandre Demeure und Sybille Caffiau. „CCBL“. Proceedings of the ACM on Human-Computer Interaction 1, EICS (30.06.2017): 1–18. http://dx.doi.org/10.1145/3099584.
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Liang, Kun, Guan Ben Du, Omid Hosseinaei, Si Qun Wang und Hui Wang. „Mechanical Properties of Secondary Wall and Compound Corner Middle Lamella near the Phenol-Formaldehyde (PF) Adhesive Bond Line Measured by Nanoindentation“. Advanced Materials Research 236-238 (Mai 2011): 1746–51. http://dx.doi.org/10.4028/www.scientific.net/amr.236-238.1746.
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To find out the penetration of PF into the wood cell wall and its effects onthe mechanical properties in the cellular level, the elastic modulus and hardness of secondary wall (S2layer) and compound corner middle lamella (CCML) near PF bond line region were determined by nanoindentation. Compare to the reference cell walls (unaffected by PF), PF penetration into the wood tissues showed improved elastic modulus and hardness. And the mechanical properties decreased slowly with the increasing the distance from the bond line, which are attributed to the effects of PF penetration into S2layer and CCML. The reduced elastic modulus variations were from18.8 to 14.4 GPa for S2layer, and from10.1 to 7.65 GPa for CCML. The hardness was from 0.67 to 0.52 GPa for S2layer, and from 0.65 to 0.52 GPa for CCML. In each test viewpoint place, the average hardness of CCML was almost as high as that of S2layer, but the reduced elastic modulus was about 50% less than that of S2layer. But the increase ratio of mechanical properties was close. All the results showed PF penetrates into the CCML. The penetration behavior and penetration depth from bond line were similar in both S2layer and CCML.
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Kamada, Kyousuke, Hiroshi Ogawa, Christoph Kapeller, Robert Prueckl, Satoru Hiroshima, Yukie Tamura, Fumiya Takeuchi und Christoph Guger. „Disconnection of the pathological connectome for multifocal epilepsy surgery“. Journal of Neurosurgery 129, Nr. 5 (November 2018): 1182–94. http://dx.doi.org/10.3171/2017.6.jns17452.
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OBJECTIVERecent neuroimaging studies suggest that intractable epilepsy involves pathological functional networks as well as strong epileptogenic foci. Combining cortico-cortical evoked potential (CCEP) recording and tractography is a useful strategy for mapping functional connectivity in normal and pathological networks. In this study, the authors sought to demonstrate the efficacy of preoperative combined CCEP recording, high gamma activity (HGA) mapping, and tractography for surgical planning, and of intraoperative CCEP measures for confirmation of selective pathological network disconnection.METHODSThe authors treated 4 cases of intractable epilepsy. Diffusion tensor imaging–based tractography data were acquired before the first surgery for subdural grid implantation. HGA and CCEP investigations were done after the first surgery, before the second surgery was performed to resect epileptogenic foci, with continuous CCEP monitoring during resection.RESULTSAll 4 patients in this report had measurable pathological CCEPs. The mean negative peak-1 latency of normal CCEPs related to language functions was 22.2 ± 3.5 msec, whereas pathological CCEP latencies varied between 18.1 and 22.4 msec. Pathological CCEPs diminished after complete disconnection in all cases. At last follow-up, all of the patients were in long-term postoperative seizure-free status, although 1 patient still suffered from visual aura every other month.CONCLUSIONSCombined CCEP measurement, HGA mapping, and tractography greatly facilitated targeted disconnection of pathological networks in this study. Although CCEP recording requires technical expertise, it allows for assessment of pathological network involvement in intractable epilepsy and may improve seizure outcome.
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Hu, H. J., S. L. Gan, Y. Tian, D. F. Zhang, J. K. Feng und Z. W. Ou. „Evaluation of chilled casting and extrusion-shear forming technology based on numerical simulation and experiments“. Materials Testing 63, Nr. 8 (01.08.2021): 728–35. http://dx.doi.org/10.1515/mt-2021-0002.
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Abstract Magnesium alloys on the surface of billets might be refined by chilled casting process, but the grains of the center of billets are coarse, and there are a lot of void defects in the center of billets. These defects can be eliminated by hot extrusion, while fibrous microstructures and strong basal textures might be formed. This paper presents a new short process technology which includes chilled casting and extrusion-shear (CCES). It is crucial to understand the effects of die structures on the deformation behaviors, strain distribution and load requirements. Three selections of processes and die structures were done by simulations and experiments which include CCES process with 4 times consecutive shearings plastic deformation, CCES process by lateral extrusion with 90° shearing angle, and combined CCES process mode. The research results show the third selection is recommended. Three-dimensional (3D) geometric models with different channel angles (30°, 45°) for the third selection CCES dies were designed. The heterogeneities of plastic deformation by CCES dies with different channel angles were analyzed from the simulation results. The simulation results show strains decrease with rising of channel angles. The lower channel angles improve the deformation heterogeneity of magnesium alloy billets. Smaller channel angles obtain higher strains and produce tinier sub-grains. The forces of the CCES process decrease with rising of channel angles. The analysis results showed that finer and uniform microstructures can be obtained if channel angles in the CCES dies are appropriate.
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Wei, Wei, Li Miao, Liping A. Cai und Howard Adler. „Modeling event attendees’ experiences during customer-customer encounters (CCEs)“. International Journal of Contemporary Hospitality Management 29, Nr. 8 (14.08.2017): 2085–102. http://dx.doi.org/10.1108/ijchm-02-2016-0106.
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Purpose The purpose of this study is to explore how event attendees experience interactive encounters in the most competitive segment of the business sector of events – conferences. Design/methodology/approach A total of 26 in-depth personal interviews was conducted with previous conference attendees. Line-by-line open coding, axial coding and selective coding are performed. Findings This study develops a framework for experiences during customer–customer encounters (CCEs), which presents a dual motivational structure that explains one’s participation in CCEs, a classification of typical CCEs, four processes that one experiences during CCEs and three levels of situational factors that influence experiences during CCEs. Originality/value This study makes one of the first attempts to propose a multidimensional conceptualization of CCE experiences using an attendee perspective. Beyond the utilitarian and social benefits, this study suggests that it is important for event studies to explore the psychological and emotional meanings of CCE experiences through an experiential lens and that the competitive battleground in event industry should lie in staging memorable experiences during CCEs.
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Wang, Pa-Chun, Chia-Chen Chu, Chih-Jaan Tai, Shu-Cheng Liang und Richard E. Gliklich. „Validation Assessment of the Chinese-Version Chronic Ear Survey: A Comparison between Data from English and Chinese Versions“. Annals of Otology, Rhinology & Laryngology 112, Nr. 1 (Januar 2003): 85–90. http://dx.doi.org/10.1177/000348940311200116.
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The Chronic Ear Survey (CES) is a valid, disease-specific measure for the evaluation of health status and treatment effectiveness for adults with chronic suppurative otitis media (CSOM). This study compares the validation properties of the English and Chinese versions of the CES. The CES was translated into Mandarin Chinese by means of a parallel model. The Chinese version of the CES (CCES) was administered to 103 patients in a prospective manner, then was validated according to established criteria for reliability, validity, and longitudinal sensitivity. The CCES demonstrated good test-retest reliability and internal consistency (Cronbach's α = 0.81). The CCES significantly correlated with the Mandarin Chinese (Taiwan) version of the generic 36-Item Short-Form Health Survey (TSF-36). The standardized response mean for the CCES total score was 2.1, indicating excellent sensitivity to clinical change. This validation study demonstrated that the performance characteristics of the CCES were equivalent to those of the English-version CES. The CCES is a valid tool for evaluation of adults with CSOM among the Chinese-speaking population.
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Chen, Zhun, Yuefei Zhuo, Guan Li und Zhongguo Xu. „What Drives Different Governance Modes and Marketization Performance for Collective Commercial Construction Land in Rural China?“ Land 10, Nr. 3 (19.03.2021): 319. http://dx.doi.org/10.3390/land10030319.
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The collective commercial construction land (CCCL) reform in China has attracted considerable attention worldwide, but studies on the influencing factors and performance of governance modes for CCCL marketization are still in their infancy. First, by deconstructing CCCL, this study developed a conceptual framework from the perspective of transaction cost economics. Based on a series of surveys, interviews, and closed questionnaires in two pilot areas, this study determined the influencing factors for governance mode choice for CCCL marketization through comparative case studies and compared the performance of the government-led and self-organized modes. This study concluded that asset specificity, uncertainty, and frequency were the main influencing factors for transaction costs, which could influence the choice of governance mode for CCCL marketization. Moreover, the characteristics of the two aforementioned governance modes, transaction costs, and specific revenue distribution resulted in different marketization performances.
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Macedo, Iara Tersia Freitas, Lorena Mayana Beserra de Oliveira, Weibson Paz Pinheiro André, José Vilemar de Araújo Filho, Jéssica Maria Leite dos Santos, Fernanda Cristina Macedo Rondon, Wesley Lyeverton Correia Ribeiro et al. „Anthelmintic effect of Cymbopogon citratus essential oil and its nanoemulsion on sheep gastrointestinal nematodes“. Revista Brasileira de Parasitologia Veterinária 28, Nr. 3 (Juli 2019): 522–27. http://dx.doi.org/10.1590/s1984-29612019065.
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Abstract The anthelmintic resistance stimulated the search for strategies for controlling gastrointestinal nematodes, including the use of free essential oils or its nanoemulsion. This study evaluated the anthelmintic efficacy of Cymbopogon citratus essential oil (CcEO) and C. citratus essential oil nanoemulsion (CcEOn). Pysicochemical analyses were performed. The in vitro effect was determined using the egg hatch test (EHT) on Haemonchus contortus and in vivo effect was evaluated in sheep infected with gastrointestinal nematodes. The animals were treated with CcEO (500 mg/kg) or CcEOn (450 mg/kg) for the fecal egg count (FEC) and the determination of worm burden. The main component of CcEO was citral. The CcEO content in the nanoemulsion was 20% (v/v), and the mean particle size was 248 nm. In EHT, CcEO and CcEOn (1.25 mg/mL) inhibited larval hatching by 98.4 and 97.1%, respectively. Three animals treated with CcEO died whereas in the group treated with CcEOn one animal died. The FEC and total worm burden of the treated groups did not differ from the negative control (p>0.05). The CcEOn showed efficacy only on H. contortus (p<0.05). In conclusion, nanoencapsulation reduced toxicity and increased efficacy on H. contortus.
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Kinoshita, I., M. Murase und A. Tomiyama. „Numerical Simulation of Size Effects on Countercurrent Flow Limitation in PWR Hot Leg Models“. Science and Technology of Nuclear Installations 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/907364.
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We have previously done numerical simulations using the two-fluid model implemented in the CFD software FLUENT6.3.26 to investigate effects of shape of a flow channel and its size on CCFL (countercurrent flow limitation) characteristics in PWR hot leg models. We confirmed that CCFL characteristics in the hot leg could be well correlated with the Wallis parameters in the diameter range of0.05 m≤D≤0.75 m. In the present study, we did numerical simulations using the two-fluid model for the air-water tests withD=0.0254 m to determine why CCFL characteristics forD=0.0254 m were severer compared with those in the range,0.05 m≤D≤0.75 m. The predicted CCFL characteristics agreed with the data forD=0.0254 m and indicated that the CCFL difference betweenD=0.0254 m and0.05 mm≤D≤0.75 mm was caused by the size effect and not by other factors.
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Srijinda, Songsak, Chamaiporn Suwanasophon, Unchalee Visawapoka und Malinee Pongsavee. „RhC Phenotyping, Adsorption/Elution Test, and SSP-PCR: The Combined Test for D-Elute Phenotype Screening in Thai RhD-Negative Blood Donors“. ISRN Hematology 2012 (14.11.2012): 1–6. http://dx.doi.org/10.5402/2012/358316.
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The Rhesus (Rh) blood group is the most polymorphic human blood group and it is clinically significant in transfusion medicine. Especially, D antigen is the most important and highly immunogenic antigen. Due to anti-D, it is the cause of the hemolytic disease of the newborn and transfusion reaction. About 0.1%–0.5% of Asian people are RhD-negative, whereas in the Thai population, the RhD-negative blood type only occurs in 0.3%. Approximately 10%–30% of RhD-negative in Eastern Asian people actually were D-elute (DEL) phenotype, the very weak D antigen that cannot be detected by indirect antiglobulin test (IAT). There are many reports about anti-D immunization in RhD-negative recipients through the transfusion of red blood cells from individuals with DEL phenotype. D-elute phenotype screening in Thai RhD-negative blood donors was studied to distinguish true RhD-negative from DEL phenotype. A total of 254 Thai serologically RhD-negative blood donors were tested for RhCE phenotypes and anti-D adsorption/elution test. In addition, RhC(+) samples were tested for RHD 1227A allele by SSP-PCR technique. The RhD-negative phenotype samples consisted of 131 ccee, 4 ccEe, 1 ccEE, 101 Ccee, 16 CCee, and 1 CcEe. The 42 Ccee and 8 CCee phenotype samples were typed as DEL phenotype and 96% of DEL samples were positive for RHD 1227A allele. The incidence of RhC(+) was 46.4%, and 48 of the 118 RhC(+) samples were positive for both anti-D adsorption/elution test and SSP-PCR technique for RHD 1227A allele. The sensitivity and specificity were 96% and 100%, respectively, for RHD 1227A detection as compared with the adsorption/elution test. In conclusion, RhC(+) phenotype can combine with anti-D adsorption/elution test and RHD 1227A allele SSP-PCR technique for distinguishing true RhD-negative from DEL phenotype.
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Nogueira, Lenise de Morais, Monalisa Ribeiro da Silva, Simone Maria dos Santos, Julianna Ferreira Cavalcanti de Albuquerque, Igor Cavalcanti Ferraz, Thaíse Torres de Albuquerque, Carlos Renato França de Carvalho Mota et al. „Antinociceptive Effect of the Essential Oil Obtained from the Leaves ofCroton cordiifoliusBaill. (Euphorbiaceae) in Mice“. Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/620865.
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Croton cordiifoliusBaill. is a shrub known as “quebra-faca” and is used to treat inflammation, pain, wounds, and gastrointestinal disturbances in the semiarid region in the northeast of Brazil. In an ethnobotanical survey in the state of Pernambuco, “quebra-faca” use was cited in 33% of the interviews. Thus, we decided to evaluate the antinociceptive effects of the essential oil fromC. cordiifolius(CcEO). Chemical analysis by gas chromatography-mass spectrometry revealed 1,8-cineole (25.09%) andα-phellandrene (15.43%) as major constituents. Antinociceptive activity was evaluated using murine models of chemically induced pain (writhing induced by acetic acid, formalin, capsaicin, and glutamate tests). Opioid and central nervous systems (CNS) involvement were also investigated. Regarding antinociceptive activity, CcEO (50 and 100 mg/kg) reduced the number of writhing responses induced by acetic acid and decreased the licking times in both phases of the formalin test. CcEO also was evaluated in capsaicin- and glutamate-induced nociception. While no effect was observed in the capsaicin test, CcEO (100 mg/kg) was effective in the glutamate test. Naloxone, an opioid antagonist, did not affect the antinociceptive activity of CcEO in writhing test. In conclusion, the antinociceptive effect of CcEO could be explained, at least in part, by inhibition of the glutamatergic system.
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Zhi, Bangdong, Xiaohong Liu, Junlin Chen und Fu Jia. „Collaborative carbon emission reduction in supply chains: an evolutionary game-theoretic study“. Management Decision 57, Nr. 4 (18.04.2019): 1087–107. http://dx.doi.org/10.1108/md-09-2018-1061.
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Purpose The purpose of this paper is to employ an emerging phenomenon in China concerning collaborative carbon emission reduction (CCER) to investigate: first, the coordination of suppliers and manufacturers within supply chains to reduce carbon emissions, and second, the role of governmental policy in facilitating this process. Design/methodology/approach This paper draws upon evolutionary game theory to develop an evolutionary game model for CCER for suppliers and manufacturers within supply chains. This includes a detailed analysis of the evolutionary direction and process in different areas, both with, and in the absence of, governmental subsidies. Findings The results demonstrate that CCER is path dependent and that its evolutionary process is influenced by the following four factors: the initial status within supply chains; the cost; the additional benefit; and the investment risk related to CCER. The research also reveals that the reward provided by manufacturers is rational over the long term, due to the excessive cost of incentives potentially preventing the implementation of CCER. Originality/value This study represents the first attempt to investigate CCER within supply chains through the application of an evolutionary game-theoretic model. The investigation of multiple factors in the model will deepen understanding of the collaborative role required for the carbon emission reduction.
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Saito, Taiichi, Manabu Tamura, Yoshihiro Muragaki, Takashi Maruyama, Yuichi Kubota, Satoko Fukuchi, Masayuki Nitta et al. „Intraoperative cortico-cortical evoked potentials for the evaluation of language function during brain tumor resection: initial experience with 13 cases“. Journal of Neurosurgery 121, Nr. 4 (Oktober 2014): 827–38. http://dx.doi.org/10.3171/2014.4.jns131195.
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Object The objective in the present study was to evaluate the usefulness of cortico-cortical evoked potentials (CCEP) monitoring for the intraoperative assessment of speech function during resection of brain tumors. Methods Intraoperative monitoring of CCEP was applied in 13 patients (mean age 34 ± 14 years) during the removal of neoplasms located within or close to language-related structures in the dominant cerebral hemisphere. For this purpose strip electrodes were positioned above the frontal language area (FLA) and temporal language area (TLA), which were identified with direct cortical stimulation and/or preliminary mapping with the use of implanted chronic subdural grid electrodes. The CCEP response was defined as the highest observed negative peak in either direction of stimulation. In 12 cases the tumor was resected during awake craniotomy. Results An intraoperative CCEP response was not obtained in one case because of technical problems. In the other patients it was identified from the FLA during stimulation of the TLA (7 cases) and from the TLA during stimulation of the FLA (5 cases), with a mean peak latency of 83 ± 15 msec. During tumor resection the CCEP response was unchanged in 5 cases, decreased in 4, and disappeared in 3. Postoperatively, all 7 patients with a decreased or absent CCEP response after lesion removal experienced deterioration in speech function. In contrast, in 5 cases with an unchanged intraoperative CCEP response, speaking abilities after surgery were preserved at the preoperative level, except in one patient who experienced not dysphasia, but dysarthria due to pyramidal tract injury. This difference was statistically significant (p < 0.01). The time required to recover speech function was also significantly associated with the type of intraoperative change in CCEP recordings (p < 0.01) and was, on average, 1.8 ± 1.0, 5.5 ± 1.0, and 11.0 ± 3.6 months, respectively, if the response was unchanged, was decreased, or had disappeared. Conclusions Monitoring CCEP is feasible during the resection of brain tumors affecting language-related cerebral structures. In the intraoperative evaluation of speech function, it can be a helpful adjunct or can be used in its direct assessment with cortical and subcortical mapping during awake craniotomy. It can also be used to predict the prognosis of language disorders after surgery and decide on the optimal resection of a neoplasm.
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Coffi, Sydney M. S., Nicaise Yalo, Bernard Ahamide und Daouda Mama. „Study of the free residual chlorine concentration in drinking water in Benin: case of Cotonou municipality“. International Journal of Biological and Chemical Sciences 14, Nr. 9 (25.03.2021): 3372–90. http://dx.doi.org/10.4314/ijbcs.v14i9.32.
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The drinking water is very qualitatively monitored. Despite this monitoring, there is a deterioration in the Free Residual Chlorine Concentration (CCRL) along the drinking water distribution network of the commune of Cotonou. The objective of studying areas of consumer vulnerability where the CCRL reaches critical thresholds (<0.1 mg / l). To achieve this, water samples were taken from various locations in the supply network every day, from 04/30/2018. The assay method used is called N-Diethyl-P-phenylene Diamine (DPD) with the use of a DR / 890 colorimeter. This work reveal that the CCRL undergoes degradation during its delivery to the consumer's taps with average concentrations mainly above the standard in force [0.1; 0.8 mg / l] at the 5% threshold. The work made it possible to establish a linear model for predicting CCRL concentration as a function of distance and to identify areas of vulnerability in the study area.
L’eau de consommation est très surveillée sur le plan qualitatif. En dépit de cette surveillance, on constate une dégradation de la Concentration en Chlore Résiduel Libre (CCRL) le long du réseau de distribution d’eau potable de la commune de Cotonou. L’objectif d’étudier les zones de vulnérabilité du consommateur où la CCRL atteint des seuils critiques (< à 0,1 mg /l). Pour y parvenir, des prélèvements d’échantillons d’eau ont été pris à divers endroits du réseau d’approvisionnement chaque jour, du 1er au 30/04/2018. La méthode de dosage utilisée est dénommée N-Diéthyl-P-phénylèneDiamine (DPD) avec usage d'un colorimètre DR/890. Ce travail à révéler, que la CCRL subi une dégradation lors de son acheminement vers les robinets du consommateur avec des concentrations moyennes majoritairement supérieures à la norme en vigueur [0,1 ; 0,8 mg/l] au seuil de 5%. Le travail a permis d’établir un modèle linéaire de prédiction de la concentration en CCRL en fonction de la distance et d’identifier les zones de vulnérabilité de la zone d’étude.
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Howard, Stephanie Anne Holler, Kathryn P. Gray, Elizabeth O'Donnell, Fiona M. Fennessy, Clair Beard und Christopher Sweeney. „Craniocaudal retroperitoneal node length as a risk factor for relapse from clinical stage I testicular germ cell tumor.“ Journal of Clinical Oncology 32, Nr. 4_suppl (01.02.2014): 363. http://dx.doi.org/10.1200/jco.2014.32.4_suppl.363.
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363 Background: To investigate if retroperitoneal craniocaudal nodal length (CCNL) or nodal volume (NV) predicts relapse risk in clinical stage I testicular cancer. Methods: This institutional review board-approved, Health Insurance Portability and Accountability Act (HIPAA)-compliant study retrospectively reviewed 826 patients with testicular cancer. One hundred eighteen out of 826 patients forming the analytic cohort had stage I disease and either more than or equal to 2 years surveillance or retroperitoneal lymph node dissection with no adjuvant chemotherapy. 3D NVs and CCNL were measured by two attending physicians in consensus. Association between relapse risk and CCNL/NV was evaluated using univariable/multivariable logistic regression analysis adjusted for known prognostic factors. Results: Sixty six out of 118 patients (56%) had nonseminomatous germ cell tumor (NSGCT) and 52 (44%) had seminomatous germ cell tumor (SGCT). Twenty one percent (25 out of 118) of patients relapsed: 24% (16 out of 66) for NSGCT and 17% (9 out of 52) for SGCT. Eighty percent of relapses were limited to the retroperitoneum; 90% of these were at the site of the largest lymph node. CCNL proved to be an independent risk factor in NSGCT using a multivariable logistic regression model adjusting for other potential known risk factors of embryonal predominance (EP) and lymphovascular invasion (LVI). For every 3 mm increase in CCNL, the risk of relapse increased by 52% (odds ratio [OR]=1.52; 95% CI=1.03- 2.25). For patients with SGCT, only the primary tumor size was an independent risk factor for relapse (OR=1.34; 95% CI=1.02-1.75). Conclusions: In NSGCT, CCNL was shown to be associated with increased risk of relapse independently of other known risk factors. If validated in a larger cohort, CCNL could provide important additional information used to inform management decisions in these patients.
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Huang, Ping, und Ronghui Huang. „Climatology and Interannual Variability of Convectively Coupled Equatorial Waves Activity“. Journal of Climate 24, Nr. 16 (15.08.2011): 4451–65. http://dx.doi.org/10.1175/2011jcli4021.1.
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Abstract Climatology and interannual variability of convectively coupled equatorial wave (CCEW) activity, including the mixed Rossby–gravity (MRG), tropical-depression-type (TD-type), equatorial Rossby (ER), and Kelvin waves, are investigated using the satellite-observed brightness temperature data from the Cloud Archive User Service. The monthly activity of CCEWs is represented by the root mean square of the daily filtered convections in each month based on the Wheeler–Kiladis filtering method. More precise seasonal cycles of CCEW activity are obtained from the meridional and zonal mean climatology. Interannual variance of CCEW activity is further investigated. Kelvin wave activity has maximum interannual variance over the eastern Pacific, while the other three waves are most variable in the intertropical convergence zone. The four active CCEWs all have significant correlation with the background convection and local sea surface temperature (SST) over the central and eastern Pacific, but they are not significantly correlated over other regions. The El Niño events may induce more trapped and active CCEWs over the central and eastern Pacific but weaker MRG and TD-type waves over the warm pool. In contrast, the El Niño Modoki has much weaker correlation with CCEW activity. CCEW activity over the southeastern Indian Ocean is negatively correlated with the Indian Ocean dipole, while that over the western and northern Indian Ocean may be determined by atmospheric internal disturbances. The tropical southern Atlantic mode is the strongest Atlantic SST anomaly mode correlated with the Atlantic CCEW activity.
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Doi, Taiga, Takashi Futatsugi, Michio Murase, Kosuke Hayashi, Shigeo Hosokawa und Akio Tomiyama. „Countercurrent Flow Limitation at the Junction between the Surge Line and the Pressurizer of a PWR“. Science and Technology of Nuclear Installations 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/754724.
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An experimental study on countercurrent flow limitation (CCFL) in vertical pipes is carried out. Effects of upper tank geometry and water levels in the upper and lower tanks on CCFL characteristics are investigated for air-water two-phase flows at room temperature and atmospheric pressure. The following conclusions are obtained: (1) CCFL characteristics for different pipe diameters are well correlated using the Kutateladze number if the tank geometry and the water levels are the same; (2) CCFL occurs at the junction between the pipe and the upper tank both for the rectangular and cylindrical tanks, and CCFL with the cylindrical tank occurs not only at the junction but also inside the pipe at high gas flow rates and small pipe diameters; (3) the flow rate of water entering into the vertical pipe at the junction to the rectangular upper tank is lower than that to the cylindrical tank because of the presence of low frequency first-mode sloshing in the rectangular tank; (4) increases in the water level in the upper tank and in the air volume in the lower tank increase water penetration into the pipe, and therefore, they mitigate the flow limitation.
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Hyland, CA, LC Wolter und A. Saul. „Three unrelated Rh D gene polymorphisms identified among blood donors with Rhesus CCee (r'r') phenotypes“. Blood 84, Nr. 1 (01.07.1994): 321–24. http://dx.doi.org/10.1182/blood.v84.1.321.321.
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Abstract Human red blood cells are traditionally typed as Rhesus (Rh)-positive or -negative depending on the presence or absence of the Rh D antigen. A recent report demonstrated that the Rh D gene is completely absent in Rh D-negative individuals. In this study, Rh D-negative blood donors with ccee (n = 25) and CCee (n = 3) phenotypes were examined for the presence of absence of the D gene. Polymerase chain reaction (PCR) probes that hybridize to the 5' and 3' regions of the Rh CcEe gene and the closely related D gene were used in a Southern analysis. The D gene was absent in all ccee phenotypes examined. The CCee phenotypes showed three Rh D polymorphisms: one donor lacked the D gene, one donor had a partial deletion on one D gene at the 3' region, and the remaining donor appeared to have one normal D gene within the intron/exon regions examined. We conclude that, while the D gene may be absent in the majority of Rh D-negative phenotypes, rarer polymorphisms also occur that prevent expression of the D antigen resulting in the Rh D-negative phenotype.
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Hyland, CA, LC Wolter und A. Saul. „Three unrelated Rh D gene polymorphisms identified among blood donors with Rhesus CCee (r'r') phenotypes“. Blood 84, Nr. 1 (01.07.1994): 321–24. http://dx.doi.org/10.1182/blood.v84.1.321.bloodjournal841321.
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Human red blood cells are traditionally typed as Rhesus (Rh)-positive or -negative depending on the presence or absence of the Rh D antigen. A recent report demonstrated that the Rh D gene is completely absent in Rh D-negative individuals. In this study, Rh D-negative blood donors with ccee (n = 25) and CCee (n = 3) phenotypes were examined for the presence of absence of the D gene. Polymerase chain reaction (PCR) probes that hybridize to the 5' and 3' regions of the Rh CcEe gene and the closely related D gene were used in a Southern analysis. The D gene was absent in all ccee phenotypes examined. The CCee phenotypes showed three Rh D polymorphisms: one donor lacked the D gene, one donor had a partial deletion on one D gene at the 3' region, and the remaining donor appeared to have one normal D gene within the intron/exon regions examined. We conclude that, while the D gene may be absent in the majority of Rh D-negative phenotypes, rarer polymorphisms also occur that prevent expression of the D antigen resulting in the Rh D-negative phenotype.
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Liu, Nan, Zhi Zeng und Ruoyu Jin. „A Survey on Users' Perspectives to Functionalities of Web-Based Construction Collaboration Extranets“. International Journal of e-Collaboration 15, Nr. 4 (Oktober 2019): 1–17. http://dx.doi.org/10.4018/ijec.2019100101.
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Construction collaboration extranets (CCEs) provide various functionalities depending on the vendors' origins, history, experiences, and financial status. Previous research has listed and described the functionalities that extranet systems can be capable of providing. However, no publication was found so far to systematically analyze users' perspectives to the provided functionalities. This article is to bridge this gap through a questionnaire survey to the users. It aims at examining user's attitude to functionalities of CCEs. The result may be useful to information system vendors, end-users and researchers involved in CCEs development and implementation.
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Souto, Marione A. Moreira, Glaucia D. Kommers, Claudio S. L. Barros, José V. M. Piazer, Raquel R. Rech, Franklin Riet-Correa und Ana L. Schild. „Neoplasias do trato alimentar superior de bovinos associadas ao consumo espontâneo de samambaia (Pteridium aquilinum)“. Pesquisa Veterinária Brasileira 26, Nr. 2 (Juni 2006): 112–22. http://dx.doi.org/10.1590/s0100-736x2006000200009.
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Foram estudados 30 bovinos com neoplasias no trato alimentar superior (TAS) associadas ao consumo espontâneo de samambaia (Pteridium aquilinum) provenientes de 27 propriedades rurais, sendo 23 no município de Jaguari e quatro em Nova Esperança do Sul, Rio Grande do Sul. A população bovina total das 27 propriedades em que ocorreram os casos era de 1.090 bovinos e havia quantidade abundante de samambaia nas áreas de pastoreio dos animais. Vinte e seis bovinos eram vacas e 4 eram machos castrados. A idade variou de 3 a 13 anos, sendo o maior número de casos entre 7 e 8 anos (46,6%). Os sinais clínicos observados incluíram emagrecimento progressivo, atonia ruminal, tosse, disfagia, regurgitação, halitose, diarréia e timpanismo. Outros sinais clínicos menos freqüentes foram apetite seletivo, dispnéia e salivação. Dois bovinos tiveram morte espontânea e 28 foram submetidos à eutanásia em estágios avançados da doença e necropsiados. Os principais achados macroscópicos e histológicos observados nos 30 bovinos localizavam-se nos mesmos locais do TAS e consistiram de papilomas, papilomas em transformação para carcinomas de células escamosas (CCEs) e CCEs. Metástases de CCEs para linfonodos regionais e outros órgãos (como fígado e pulmões) foram também observadas (18/30). Vinte e nove bovinos tinham papilomas de diversos tamanhos, sendo a quantidade variável entre leve (45%), moderada (38%) e acentuada (17%). Nos papilomas examinados microscopicamente, foram observadas três fases de desenvolvimento: a) fase de inicial de crescimento, b) fase de desenvolvimento, e c) fase de regressão. Em 16 bovinos, observou-se a transformação maligna de papilomas em CCEs. Os CCEs eram únicos (12/30) ou múltiplos (18/30) e variaram quanto ao grau de diferenciação celular entre bem, moderadamente ou pouco diferenciados. Quando a distribuição dos CCEs de maior extensão foi agrupada em regiões cranial (base da língua, faringe/orofaringe, epiglote), média (terços cranial, médio e caudal do esôfago) e caudal (entrada do rúmen e rúmen) do TAS, observou-se que a localização era cranial em 39% dos casos, média em 16%, e caudal em 45%. Utilizando-se esse mesmo critério de agrupamento, porém considerando o número total de vezes em que CCEs (de tamanhos variados) foram diagnosticados nas regiões cranial, média e caudal, os números alteraram-se para 34, 26 e 40%, respectivamente. As evidências epidemiológicas e histomorfológicas relatadas neste estudo reforçam as observações de uma estreita correlação entre a infecção pelo papiloma-vírus bovino tipo 4, causador da papilomatose digestiva, e a co-carcinogênese química dos princípios tóxicos da samambaia na patogênese dos CCEs do TAS de bovinos. Entretanto, a presença de alterações pré-neoplásicas (áreas de displasia), áreas de CCE in situ ou CCEs em estágios iniciais de desenvolvimento, independentemente da presença de papilomas no local, mostram claramente ser possível o desenvolvimento de CCEs diretamente do epitélio normal, possivelmente por uma ação direta dos carcinó-genos químicos da samambaia.
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Sudo, Y. „Mechanism and Effects of Predominant Parameters Regarding Limitation of Falling Water in Vertical Countercurrent Two-Phase Flow“. Journal of Heat Transfer 118, Nr. 3 (01.08.1996): 715–24. http://dx.doi.org/10.1115/1.2822691.
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In this study, an investigation was carried out to clarify the mechanism of countercurrent flow limitation (CCFL) or flooding, that is, limitations in the falling water mass flux in countercurrent two-phase flow in vertical channels, and to identify the effects of predominant parameters regarding CCFL, adopting the criterion that the CCFL condition be given by an envelope of momentum equation applied for the entire length of the channel with respect to any void fraction. As a result, it was found that the analytical model proposed could adequately predict all existing experimental results investigated in this study. In the channel configuration, circular, rectangular, and annular or planar channels, channel dimensions of diameter, gap size, width or circumference, and length, interfacial and wall friction, water injection mode, and inlet water subcooling were dominant parameters. Therefore, both the mechanism and the quantitative effects of CCFL have been identified.
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Fontainha, Elsa, und Elisabetta Lazzaro. „CULTURAL AND CREATIVE ENTREPRENEURS IN FINANCIAL CRISES: SAILING AGAINST THE TIDE?“ Scientific Annals of Economics and Business, Special Issue (2019): 73–89. http://dx.doi.org/10.47743/saeb-2019-0022.
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We focus on a number of idiosyncrasies of cultural and creative entrepreneurs (CCEs) to study CCEs’ capacity of resilience under times of downturn (economic, financial and debt crisis). We analyse CC firms’ demography (born and dead), trends and performance and the association between subsidies received and firm survival. We look at mostly micro firms in a country where CCEs are particularly challenged from the financial perspective, namely Portugal. We exploit the unique availability of accounting micro data at private firm level in a time span of 8 years (2004-2011), which allows to include the effects of the latest financial crisis, and to understand the evolution of the economic success criterion. The obtained results about the impact of subsidies on survival are interesting in both CCEs and policy perspectives, suggesting a positive impact of subsidies in periods of downturn, and negative impact of subsidies in periods of growth of the economy. Further, CC firms revealed to be more dynamic than other firms in other sectors.
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Kim, Yoon Soo, Kwang Ho Lee, Jong Sik Kim und Adya P. Singh. „Lignin masks the presence of fibrillar network structure in the cell corner middle lamella (CCML)“. Holzforschung 69, Nr. 1 (01.01.2015): 121–26. http://dx.doi.org/10.1515/hf-2014-0032.
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Abstract The presence of fibrillar structures (FS) in the cell corner middle lamella (CCML) regions was demonstrated in several species of plants. The FS in the CCML of bass wood, oak wood, and bamboo became clearly visible after removal of lignin by wood decay fungi. The occurrence of FS in the CCML was also confirmed by examining early stages of cell wall formation in silver poplar, Japanese red pine, Arabidopsis and alfalfa. The fibrillar texture became increasingly less defined with the onset of lignification as the interfibrillar spaces were masked by lignin polymers and the fibrillar network became embedded within the lignin matrix. The FS stained positively with PATAg and ruthenium red, which is interpreted to be an indicator of the presence of structural polysaccharides (non-cellulosics and pectins). Our work demonstrated that fibrillar network is a characteristic feature of CCML of plant cell walls that is clearly visible prior to lignification of this cell wall region, but becomes invisible after the deposition of lignin.
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Rashid, A. N. M. Bazlur, und Tonmoy Choudhury. „Cooperative Co-Evolution and MapReduce“. International Journal of Information Technology Project Management 12, Nr. 1 (Januar 2021): 29–62. http://dx.doi.org/10.4018/ijitpm.2021010102.
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Real-word large-scale optimisation problems often result in local optima due to their large search space and complex objective function. Hence, traditional evolutionary algorithms (EAs) are not suitable for these problems. Distributed EA, such as a cooperative co-evolutionary algorithm (CCEA), can solve these problems efficiently. It can decompose a large-scale problem into smaller sub-problems and evolve them independently. Further, the CCEA population diversity avoids local optima. Besides, MapReduce, an open-source platform, provides a ready-to-use distributed, scalable, and fault-tolerant infrastructure to parallelise the developed algorithm using the map and reduce features. The CCEA can be distributed and executed in parallel using the MapReduce model to solve large-scale optimisations in less computing time. The effectiveness of CCEA, together with the MapReduce, has been proven in the literature for large-scale optimisations. This article presents the cooperative co-evolution, MapReduce model, and associated techniques suitable for large-scale optimisation problems.
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Hartshorne, S., D. J. Richardson und J. Simon. „Multiple haem lyase genes indicate substrate specificity in cytochrome c biogenesis“. Biochemical Society Transactions 34, Nr. 1 (20.01.2006): 146–49. http://dx.doi.org/10.1042/bst0340146.
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c-Type cytochromes are a widespread class of proteins that play a vital role in the energy-conserving metabolism of prokaryotic and eukaryotic organisms. The key event in cytochrome c biogenesis is the covalent attachment of the haem cofactor to two (or rarely one) cysteine residues arranged in a haem c-binding motif such as CX2–4CH, CXXCK or X3CH. This reaction is catalysed by the membrane-bound enzyme CCHL (cytochrome c haem lyase). Different CCHLs have been described and some of them are dedicated to distinct haem c-binding motifs of cytochromes that are encoded in the vicinity of the respective CCHL gene. Various bacterial genomes contain multiple copies of CCHL-encoding genes, suggesting the presence of non-conventional or even as yet unrecognized haem c-binding motifs. This assumption is exemplified in the present study using the proteobacterium Wolinella succinogenes as a model organism whose genome encodes three CCHL isoenzymes. The discovery of a novel conserved multihaem cytochrome c (MccA) is described.
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Bhana, Kerisha, John Lazarus, Ken Kesner und Jeff John. „Florid cystitis cystica et glandularis causing irreversible renal injury“. Therapeutic Advances in Urology 13 (Januar 2021): 175628722110224. http://dx.doi.org/10.1177/17562872211022465.
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Cystitis cystica et glandularis (CCEG) is widely believed to be innocuous and self-limiting. We report a case of a 32-year-old male patient who was found to have gross bilateral hydroureter and hydronephrosis and an estimated glomerular filtration rate of 3 ml/min/1.73 m2. Cystoscopy revealed extensive cystic and nodular lesions involving most of the bladder urothelium, which proved to be CCEG on histopathological analysis. Retrograde and anterograde stents could not be inserted due to obstruction of the ureters at the level of the vesicoureteric junction. Percutaneous nephrostomies were subsequently inserted. Although there was evidence of improvement of the CCEG on follow-up cystoscopy, no improvement of renal function, despite decompression with percutaneous nephrostomies, was seen. He was subsequently placed on the waiting list for a renal transplant. We believe this to be the only known case reported of florid CCEG obstructing the upper urinary tracts bilaterally, causing irreversible renal injury.
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Odaguiri, Juliana, Valéria Aoki, Lígia Maria Ichimura Fukumori, Alexandre Marques Périgo, Nilceo Scwery Michalany, Isabela Fontana und Carlos Eduardo Larsson. „Correlation between Histopathological Findings and Results of Direct Immunofluorescence in the Diagnosis of Canine Localized Cutaneous Chronic Lupus Erythematosus“. Acta Scientiae Veterinariae 45, Nr. 1 (29.08.2017): 8. http://dx.doi.org/10.22456/1679-9216.80447.
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Background: Localized chronic cutaneous lupus erythematosus (CCLE), also known as discoid lupus erythematosus, is one of the most prevalent canine autoimmune skin diseases. Histopathology is considered the gold standard for the diagnosis of CCLE and the accuracy of which can be increased by use of direct immunofluorescence (DIF). This study aimed to investigate the fluorescence pattern revealed by DIF in cases of canine localized CCLE and to establish and compare its effectiveness with that obtained from histopathology.Materials, Methods & Results: Eleven dogs suspicious to localized CCLE, i.e., those animals that presented mucocutaneous lesions as erythema, leucoderma, erosive-ulcerative lesions, and loss of nasal planum architecture and its transition to the haired skin underwent medical physical and laboratory examinations (blood count, platelet count, determination of alanine transaminase, alkaline phosphatase, total protein, serum albumin, urea, creatinine). Only those animals that proved to be normal across both the physical and laboratorial evaluation were included in Group I. Animals belonging to this group were submitted to general anesthesia to biopsy two samples of lesioned skin from nasal planum to histopathologic examination and DIF test. Five dogs with no skin lesions were included in Group II as negative control to the DIF assay. Two samples of no lesioned skin from nasal planum were biopsied to histopathologic and DIF evaluation. The kappa (k) coefficient was used to determine the degree of agreement and reliability of the results of both tests. A P-value < 5% was considered to be statistically significant. In Group I, all animals were normal across both the physical and laboratorial evaluation. A diagnosis of canine CCLE was established in 81.8% (9/11) of the animals based on histopathology analysis. Two dogs, numbers 10 and 11, respectively, had histopathologic findings suggestive of cutaneous leishmaniasis and compatible with canine demodicosis. The DIF assay confirmed the diagnostic of canine CCLE in 100% (11/11) of the cases, including dogs numbers 10 and 11. Direct immunofluorescence positivity for canine localized CCLE was determined by the presence of homogeneous green fluorescence in the basement membrane zone, with IgM and C3 immunoreagents being found at a significantly higher frequency (P = 0.007) than IgA and IgG (P = 0.017 and P = 0.037, respectively). In Group II, no alterations from histopathologic examination and unspecific fluorescence from DIF reaction were shown in all animals belonging to this group. A substantial and significant degree of agreement or reliability (k = 0.738 and P = 0.002, respectively) was established between the results of both tests.Discussion: In veterinary medicine, there is a lack of studies about DIF around autoimmune dermatoses. This is the first manuscript comparing histopathological and direct immunofluorescence findings in the diagnostic of dogs with localized CCLE. In the present study, the positivity to the DIF assay for canine localized CCLE was established by the presence of green fluorescence of a homogeneous morphologic pattern, especially for IgM and C3, located in the BMZ and cutaneous annexes. Direct immunofluorescence excluded the suspicion of cutaneous leishmaniasis determined by the histopathological findings and confirmed the diagnostic of canine localized CCLE in the dog number 10. Statistically, a substantial degree of agreement and reliability was shown between DIF and histopathology. Therefore, we concluded that the DIF assay is a highly effective and useful complementary examination that improves our ability to diagnose canine CCLE.
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Jin, Haisheng, Shinji Egashira und K. W. Chau. „Carbon to chlorophyll-a ratio in modeling long-term eutrophication phenomena“. Water Science and Technology 38, Nr. 11 (01.12.1998): 227–35. http://dx.doi.org/10.2166/wst.1998.0472.
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Carbon to chlorophyll-a ratio (CCHL) is formulated based on the assumption that adaptive changes in carbon to chlorophyll occur so as to maximize the specific growth rate for ambient conditions, including solar radiation and water temperature. With the dynamic CCHL, an unsteady two-layered, two-dimensional eutrophication numerical model for density stratified coastal waters has been developed. Saturated light intensity (IS) is determined as weighted average of the light intensity for previous three days to incorporate light acclimation by phytoplankton. The bottom water anoxic condition during summer in Tolo Harbour, Hong Kong is successfully reproduced by the present method. Otherwise, the simulation with a constant CCHL gave a wrong result.
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Xu, Ye, und Zhuo Wang. „Genetic Algorithm Optimized CCEM for Complex Topology“. Mathematical Problems in Engineering 2012 (2012): 1–14. http://dx.doi.org/10.1155/2012/383248.
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To evaluate how much two different complex topologies are similar to each other in a quantitative way is an essential procedure in large-scale topology researches and still remains an NP problem. Cross-correlation evaluation model (CCEM) together with Genetic Algorithm (GA) is introduced in this paper trying to solve this issue. Experiments have proved that SLS (Signless Laplacian Spectra) is capable of identifying a topology structure and CCEM is capable of distinguishing the differences between corresponding topology SLS eigenvectors. CCEM used in GA is recommended at last since a way of not finding the optimum solution in GA is a good way to reduce computing complexity.
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Juarsa, Mulya, Nandy Putra, Harinaldi und Anhar Riza Antariksawan. „Experimental Study on Counter Current Flow Limitation Based on Variation of Gap Size in Narrow Rectangular Channel during Quenching Process“. Applied Mechanics and Materials 590 (Juni 2014): 613–17. http://dx.doi.org/10.4028/www.scientific.net/amm.590.613.
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The Effect of gap size to counter current flow limitation (CCFL) in vertical rectangular channel was studied in this paper. Experiment was conducted by using two vertical plate with 1 mm, 2 mm, and 3 mm narrow gap. The initial temperature of plate was decided at 600oC. Flow rate and temperature of cooling water were controlled about 0.09 L/s and 90oC respectively. Non-dimensional superficial velocity for water is 0.05-0.09 and non-dimensional superficial velocity for vapor is 3.20-3.2. The result shows that the existence of CCFL in the vertical rectangular narrow channels. A new correlation for CCFL base on Wallis has been proposed.
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Warren, Mark R., José Calderón, Luke Aubry Kupscznk, Gregory Squires und Celina Su. „Is Collaborative, Community-Engaged Scholarship More Rigorous Than Traditional Scholarship? On Advocacy, Bias, and Social Science Research“. Urban Education 53, Nr. 4 (14.03.2018): 445–72. http://dx.doi.org/10.1177/0042085918763511.
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Contrary to the charge that advocacy-oriented research cannot meet social science research standards because it is inherently biased, the authors of this article argue that collaborative, community-engaged scholarship (CCES) must meet high standards of rigor if it is to be useful to support equity-oriented, social justice agendas. In fact, they argue that CCES is often more rigorous than traditional scholarship. The authors draw from cases of CCES that they conducted to provide evidence and examples. They discuss the importance of relationship building and trust in addressing the tensions that can arise between the demands of knowledge production and action-oriented social change.
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Massardo, Domenica Rita, Stephan G. Zweifel, Norio Gunge, Isamu Miyakawa, Nobundo Sando, Angelica Del Giudice, Klaus Wolf und Luigi Del Giudice. „Use of lycorine and DAPI staining in Saccharomyces cerevisiae to differentiate between rho0 and rho- cells in a cce1/Δcce1 nuclear background“. Canadian Journal of Microbiology 46, Nr. 11 (01.11.2000): 1058–65. http://dx.doi.org/10.1139/w00-096.
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In the yeast Saccharomyces cerevisiae, mutants are viable with large deletions (rho-), or even complete loss of the mitochondrial genome (rho0). One class of rho- mutants, which is called hypersuppressive, is characterised by a high transmission of the mutated mitochondrial genome to the diploid progeny when mated to a wild-type (rho+) haploid. The nuclear gene CCE1 encodes a cruciform cutting endonuclease, which is located in the mitochondrion and is responsible for the highly biased transmission of the hypersuppressive rho- genome. CCE1 is a Holliday junction specific endonuclease that resolves recombination intermediates in mitochondrial DNA. The cleavage activity shows a strong preference for cutting after a 5'-CT dinucleotide. In the absence of the CCE1 gene product, the mitochondrial genomes remain interconnected and have difficulty segregating to the daughter cells. As a consequence, there is an increase in the fraction of daughter cells that are rho0. In this paper we demonstrate the usefulness of lycorine, together with staining by 4',6-diamidino-2-phenylindole (DAPI), to assay for the mitotic stability of a variety of mitochondrial genomes. We have found that rho+ and rho- strains that contain CT sequences produce a large fraction of rho0 progeny in the absence of CCE1 activity. Only those rho- mitochondrial genomes lacking the CT recognition sequence are unaffected by the cce1 allele.Key words: yeast, mitochondria, hypersuppressive, Saccharomyces cerevisiae, lycorine.
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Donaldson, Lloyd A., Adya P. Singh, Arata Yoshinaga und Keiji Takabe. „Lignin distribution in mild compression wood of Pinus radiata“. Canadian Journal of Botany 77, Nr. 1 (01.06.1999): 41–50. http://dx.doi.org/10.1139/b98-190.
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Lignin distribution in the tracheid cell wall of mild compression wood in Pinus radiata D. Don was examined by interference microscopy, confocal fluorescence microscopy, and ultraviolet (UV) microscopy. Two anatomically different samples of mild compression wood were compared with a sample of normal wood using quantitative interference microscopy and microdensitometry combined with confocal fluorescence microscopy to estimate the quantitative or semiquantitative lignin distribution in the S2 and S2L regions of the secondary cell wall and of the cell corner middle lamella (CCML). One of these samples was briefly examined by UV microscopy for comparison. Quantitative interference microscopy provided information on lignin concentration in different regions of the cell wall with values of 26, 46, and 57%, respectively, for the S2, S2L, and CCML regions of sample 1 and 20, 29, and 46%, respectively, for the same regions of sample 2. Microdensitometry of confocal fluorescence images provided semiquantitative information on the relative lignin distribution based on lignin autofluorescence. Comparison between the two compression wood samples using autofluorescence gave results that were in partial agreement with interference microscopy with respect to the relative lignification levels in the S2, S2L, and CCML regions. Some improvement was achieved by using calibration values for hemicellulose rather than holocellulose for interference data in the S2L region. Results for UV microscopy performed on sample 1 indicated that the lignification of the CCML region was comparable with that of the S2L region in this sample but with some variation among cells. All three techniques indicated significant variation in lignification levels of the S2L and CCML regions among adjacent cells and a significant reduction in the lignification of the CCML region compared to normal wood.Key words: lignin distribution, interference microscopy; confocal fluorescence microscopy, UV microscopy, mild compression wood, Pinus radiata D. Don.
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Johnson, Sarah, Ray McCarthy, Brian Fahy, Oana Madalina Mereuta, Seán Fitzgerald, Julien Gaudirc, Jean-Paul Remadi et al. „Development of an in vitro model of calcified cerebral emboli in acute ischemic stroke for mechanical thrombectomy evaluation“. Journal of NeuroInterventional Surgery 12, Nr. 10 (03.01.2020): 1002–7. http://dx.doi.org/10.1136/neurintsurg-2019-015595.
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BackgroundCalcified cerebral emboli (CCEs) are a rare cause of acute ischemic stroke (AIS) and are frequently associated with poor outcomes. The presence of dense calcified material enables reliable identification of CCEs using non-contrast CT. However, recanalization rates with the available mechanical thrombectomy (MT) devices remain low.ObjectiveTo recreate a large vessel occlusion involving a CCE using an in vitro silicone model of the intracranial vessels and to demonstrate the feasability of this model to test different endovascular strategies to recanalize an occlusion of the M1 segment of the middle cerebral artery (MCA).MethodsAn in vitro model was developed to evaluate different endovascular treatment approaches using contemporary devices in the M1 segment of the MCA. The in vitro model consisted of a CCE analog placed in a silicone neurovascular model. Development of an appropriate CCE analog was based on characterization of human calcified tissues that represent likely sources of CCEs. Feasibility of the model was demonstrated in a small number of MT devices using four common procedural techniques.ResultsCCE analogs were developed with similar mechanical behavior to that of ex vivo calcified material. The in vitro model was evaluated with various MT techniques and devices to show feasibility of the model. In this limited evaluation, the most successful retrieval approach was performed with a stent retriever combined with local aspiration through a distal access catheter, and importantly, with flow arrest and dual aspiration using a balloon guide catheter.ConclusionCharacterization of calcified tissues, which are likely sources of CCEs, has shown that CCEs are considerably stiffer than thrombus. This highlights the need for a different in vitro AIS model for CCEs than those used for thromboemboli. Consequentially, an in vitro AIS model representative of a CCE occlusion in the M1 segment of the MCA has been developed.
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Mondal, AK, und PK Chattopadhyay. „Influence of the micro-structural factors upon thermal and mechanical properties of various bag leathers“. Bangladesh Journal of Scientific and Industrial Research 52, Nr. 3 (03.10.2017): 167–76. http://dx.doi.org/10.3329/bjsir.v52i3.34147.
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Four different bag leathers, such as, Sheep Bag Leather (SBL), Buffalo Vegetable Tanned Leather (BVTL), Cow Drum Dyed Dry Milled Leather (CDDDML), and Cow Crocodile Print Leather (CCPL), were processed by different methods from respective wet-blues of Indian origin. Thermal degradation pro?le and mechanical properties of the samples were evaluated, and crosslink densities of each sample were measured by ?tment of Mooney-Rivlin equation on stress-strain plots. Morphological characteristics (e.g. ?bre structure, ?bre thickness, splitting etc.) of all the specimens were investigated by image analyses of SEM photomicrographs. The highest crosslinking density for BVTL was attributed to its higher ?bre and ?bril thicknesses coupled with rigorous retanning by vegetable tannins and syntans. Embossing at higher temperature and pressure reduced CCPLs elongation-at-break value and hence stretchiness possibly due to the development of set properties within the CCPL matrix. SBL was noted to contain huge void spaces that increased its stretchiness, and melamine formaldehyde syntans showed pronounced in?uence in increasing the thermal resistance of both CCPL and CDDDML.Bangladesh J. Sci. Ind. Res. 52(3), 167-176, 2017