Zeitschriftenartikel zum Thema „Cathedrals – Europe – Juvenile literature“

This article examines the architectural patronage of King Alfonso X and the notion of a ‘Court Style’ in thirteenth-century Gothic architecture. Following brief consideration of problems of evidence, I briefly sketch common characteristics of the architectural patronage of Alfonso’s royal rivals and allies across Europe and the Iberian Peninsula. This prompts reassessment of the king’s relationships with mendicant and Cistercian orders, and then detailed consideration of his financial contributions to the cathedrals of Toledo, Burgos and León. Although royal heraldry and imagery is prominent in all three cathedrals, I argue that Alfonso probably did not play a significant role in promoting rayonnant architecture in his kingdom. The most distinctive feature of his patronage lies in his support for work on the converted mosque-cathedrals of Seville and especially Córdoba. Finally, I consider a number of projects associated with Alfonso in Seville, notably the Gothic palace in the Alcázar.

In Rome, Emperor Constantin I started to build the most ancient cathedral – the five-nave Archbasilica of St. John in Lateran, but the Lateran Palace was given as a present to Bishop of Rome for his residence. Perimeter building blocks set up the building complex. In Europe, during the 6th–9th centuries numerous rulers proclaimed Christianity as the only religion in the country. The Church strengthened its impact on the society and governmental administration. In Rome, like in Jerusalem, a religious centre was created, but in the middle of the 8th century, a city-state Vatican was founded, and on one of hills, the Pope’s residence was placed. Christians organized structures governed by Bishops and founded Catholic church-states – bishoprics. In the late 12th century, subjugation of the lands populated by the Balts and the Finno-Ugric tribes began. Bishoprics and cult centres were founded, and residences for Bishops and Canonical Chapters were envisaged. The bishopric main building was the cathedral. In Europe during lots of centuries evolution of the cathedral building-type happened. In the Balts and Finno-Ugric lands cathedrals were affected by local building traditions. The origins of the Riga Cathedral (Latvian: Rīgas Doms) can be found in 1201–1202, when the bishopric centre from Üxküll was moved to the newly-founded Riga, where the Bishop’s residence was built on a geopolitically and strategically convenient place. The most important centres to look for inspirations were Braunschweig, Westfalen, Köln, Lübeck, Ratzeburg, Bremen, Hamburg. Research problem: interpretations of sacral building typology and terminology application cause difficulties in the research of historical building plans. Research topicality: evolution of the cathedral building-type and impact of cathedral building complexes on formation and planning of medieval urban structures during the 13th and 14th century. Goal of the research: analyse planning of historical structure in urban centres of bishoprics to determine significance of cathedrals as architectural dominances in spatial composition of towns. Research novelty: this research is based on Latvian historians and archaeologists’ former studies. Nevertheless, opportunities provided by the analysis of urban planning and cartographic materials have been used, and created building due to local construction traditions has been assessed in the European context. Results: study of architecture, layout formation and structure of cathedrals on the southern Baltic Seacoast lands during the 13th and 14th centuries. Main methods applied: this study is based on research and analysis of archive documents, projects and cartographic materials of urban planning, as well as study of published literature and inspection of buildings in nature.

BackgroundIn 2012, a European initiative called Single Hub and Access point for pediatric Rheumatology in Europe (SHARE) was launched to optimise and disseminate diagnostic and management regimens in Europe for children and young adults with rheumatic diseases. Juvenile dermatomyositis (JDM) is a rare disease within the group of paediatric rheumatic diseases (PRDs) and can lead to significant morbidity. Evidence-based guidelines are sparse and management is mostly based on physicians' experience. Consequently, treatment regimens differ throughout Europe.ObjectivesTo provide recommendations for diagnosis and treatment of JDM.MethodsRecommendations were developed by an evidence-informed consensus process using the European League Against Rheumatism standard operating procedures. A committee was constituted, consisting of 19 experienced paediatric rheumatologists and 2 experts in paediatric exercise physiology and physical therapy, mainly from Europe. Recommendations derived from a validated systematic literature review were evaluated by an online survey and subsequently discussed at two consensus meetings using nominal group technique. Recommendations were accepted if >80% agreement was reached.ResultsIn total, 7 overarching principles, 33 recommendations on diagnosis and 19 recommendations on therapy were accepted with >80% agreement among experts. Topics covered include assessment of skin, muscle and major organ involvement and suggested treatment pathways.ConclusionsThe SHARE initiative aims to identify best practices for treatment of patients suffering from PRD. Within this remit, recommendations for the diagnosis and treatment of JDM have been formulated by an evidence-informed consensus process to produce a standard of care for patients with JDM throughout Europe.

As the patron of travelers, Sr. Christopher inspired one of the most popular cults to spread throughout medieval Europe. The Iberian Peninsula was no exception: his gigantic following spanned the region and his image adorned the walls of most churches and cathedrals. Manifestations were not limited to the plastic arts, however, and paratheatrical representations of St. Christopher were fairly common in processions celebrating Corpus Christi and other religious holidays, especially in Valencia, where the saint enjoyed even greater esteem. Furthermore, the mystery of his conversi on and martyrdom was also staged during religious festivals during the fifteenth cenrury. This essay traces the evolution of the hugely popular cult of St. Christopher in medieval Iberia by looking at various artistic (re)presentations of the converted Canaanite, paying special attention to the Valencian processions and two extant autos sacramentales—one written in Valencian and the other in Castilian.

In 2012, a European initiative called Single Hub and Access point for paediatric Rheumatology in Europe (SHARE) was launched to optimise and disseminate diagnostic and management regimens in Europe for children and young adults with rheumatic diseases. Juvenile localised scleroderma (JLS) is a rare disease within the group of paediatric rheumatic diseases (PRD) and can lead to significant morbidity. Evidence-based guidelines are sparse and management is mostly based on physicians’ experience. This study aims to provide recommendations for assessment and treatment of JLS. Recommendations were developed by an evidence-informed consensus process using the European League Against Rheumatism standard operating procedures. A committee was formed, mainly from Europe, and consisted of 15 experienced paediatric rheumatologists and two young fellows. Recommendations derived from a validated systematic literature review were evaluated by an online survey and subsequently discussed at two consensus meetings using a nominal group technique. Recommendations were accepted if ≥80% agreement was reached. In total, 1 overarching principle, 10 recommendations on assessment and 6 recommendations on therapy were accepted with ≥80% agreement among experts. Topics covered include assessment of skin and extracutaneous involvement and suggested treatment pathways. The SHARE initiative aims to identify best practices for treatment of patients suffering from PRDs. Within this remit, recommendations for the assessment and treatment of JLS have been formulated by an evidence-informed consensus process to produce a standard of care for patients with JLS throughout Europe.

Although evidence regarding the journey-to-crime in juvenile offenders is available for some areas of the world, little is known about their mobility patterns in Southern Europe. Variables such as prosocial facilities, transport stations, or socioeconomic backdrop have been proved to influence the traveled distance. Therefore, we aimed to confirm previous findings in the journey-to-crime literature using data provided by the Juvenile Justice Department of the Basque Country (Spain). Although some results are in line with those of previous studies, emphasizing the relevance of environmental factors for better understanding crime patterns in the juvenile population, other specific patterns also emerged that suggest the need to replicate research across countries and to consider specific behavior patterns and styles of spatial design in each study setting.

Abstract The criminal responsibility and the system of sanctioning juvenile offenders is one of fundamental criminal law issues. Individuals who start a criminal career early on are usually not easy to reintegrate into normal life. That is one reason why it is neces­sary to discuss the problem of juvenile justice in depth. The legal literature in the Czech Republic is devoted to this topic on a large scale, however Hungarian legislation has not yet been analysed fo purposes of comparation. The Czech Republic and Hungary fall under the United Nations categorization to Eastern Europe and therefore certain similar features can be assumed. On the other hand any identified differences may be the basis for future changes of the legislation.

Despite extensive engagement, children were invisible in the programs of the nineteenth-century Protestant missionary conferences. By the early 1900s this had noticeably changed as denominations and missionary organizations sought to maximize and enhance juvenile missionary interest. Childhood was the key stage in which to establish habits; the future depended upon “the education of the childhood of the race, in missionary matters as in all others.” Literature was pivotal and periodicals were deemed to be the most effective literary form. They provided the young with “impressions which will never be lost . . . nothing will appeal to the young more strongly than stories from beyond the seas, of strange people who know not of Christ, but who need His gospel.” Juvenile missionary periodicals were ubiquitous in Britain, Europe, and America, but they are still only partially understood. Adult and juvenile literature was qualitatively different so that “any adequate analysis . . . requires to be grounded in an understanding of the construction of childhood in the Victorian and Edwardian eras.” This task remains very much a work in progress. Most recent scholarship tends to discursively situate children's periodicals with respect to religion, culture, and politics. All agree on at least a broad two-fold function: the spiritual and the philanthropic. Periodicals per se were an integral part of a large and pervasive Victorian corpus of juvenile religious and moral literature. At the same time missionary periodicals were different. They emphasized child agency by encouraging a “participatory relationship” between readers and their subject. Children became active agents “in a diaologic relationship with [their] world.”

To quantify the impact of forest management practices and tree growth rate on the potential uses of Douglas-fir wood, nine physico-mechanical properties were studied on more than 1250 standardized clear specimens. These were collected from trees cut in 11 even-aged stands (six trees per stand) located in Wallonia (southern Belgium). Stands were 40 to 69 years old, and mean tree girth was ca. 150 cm. Mean ring width of the 66 trees ranged from 3 to more than 7 mm. Statistical analysis showed significant but weak effects of ring width on the studied properties. Considered jointly, mean ring width and cambial age of the test specimens only explained 28% to 40% of the variability of their properties. Also, when ring width increases, these properties display higher decreases in juvenile wood than in mature wood. From a technological standpoint, maintaining mean ring width under 4 mm in juvenile wood and 6 mm in mature wood should accommodate all potential uses of Douglas-fir wood. However, considering that density appeared to be the main driver of wood properties, our results and the literature corroborate the importance of genetic selection as a complement to silvicultural measures to improve or guarantee the technological properties of Douglas-fir wood.

The topotypes (adult and juvenile instars) of the arctic oribatid mite Hermannia scabra (L. Koch, 1879) (Oribatida, Hermanniidae) from Vaygach Island (easternmost arctic Europe) were investigated and compared with those of Hermannia gigantea Sitnikova, 1975 collected from southwest Taymyr Peninsula, northern Middle Siberia, resulting in the following new taxonomic proposal: Hermannia scabra (L. Koch, 1879) (= Hermannia gigantea Sitnikova, 1975, syn. nov.). The morphology of its all instars is described and illustrated in detail on the base of specimens collected from the northern West Siberia (Shokalsky Island). The main morphological traits are summarized. Two northern species of Hermannia with granulate notogaster, namely H. scabra and H. nodosa Michael, 1988, were regularly mixed up in the literature. Their differential diagnosis is provided after elaboration of spacious materials. The morphological differences of juvenile instars of five species of Hermannia (H. gibba (C.L. Koch, 1839), H. jesti Travé, 1977, H. nodosa, H. reticulata Thörell, 1871, and H. scabra) are given. The biotopic preferences of arctic members of Hermannia are briefly observed.

Juvenile instars of oribatid mites of the family Phenopelopidae are well known compared to most other families, however, information on the morphological ontogeny of the majority of species is still insufficient or unknown. Comparative characteristics of immatures of species of Phenopelopidae are given based on our own data and available literature sources. The major characteristics of immature instars of 11 species are presented, and the morphological ontogeny of Eupelops variatus (Mihelčič, 1957) is investigated based on material from southern Europe. From these studies, it can be generalized that the juvenile morphologies of phenopelopid genera are quite similar and uniform. The juveniles have plicate integument, marginally flattened opisthonotum, and short gastronotic setae c1, c3 and of the d-series. The juveniles of the phenopelopid species differ from one another in morphological characters such as body size, development of the prodorsal ridges, lamellar, interlamellar as well as gastronotic setae of c2, lp and h-series either in larva or nymphs, and all these characters have species-specific value.

ABSTRACT During the nineteenth century the role of women was very much restricted. In the geosciences, women were not able to study and thus even less able to publish. Here the work of one female writer is presented who, due to her upbringing in an intellectual family with close connections to the most celebrated scientists in Prussia/Germany, such as Alexander von Humboldt, the mineralogist Christian Samuel Weiss, Ernst Haeckel and many others, was aware of scientific progress and the discussions of the times. Based on her unusual education by teachers and scientists and her intellectual abilities, and knowledge acquired through marriage to a well-established geoscientist, she wrote popular juvenile literature that included geological and palaeontological content. This scientific content was typically woven into fairy tales or novels for adolescent girls and served as a way to spread geoscientific knowledge to a large audience.

Russia's accession to the Council of Europe and the signing of relevant international agreements contributed to the development of regulations on the rights of a child and branching juvenile law in the Russian legal system. Meanwhile, it should be pointed out that processes of legal regulation in the field of the formation of the legislative basis of juvenile law are in some way incomplete, which is the result of the imperfection of the existing legal acts affecting the rights and interests of minors. The issue of the expediency of creating juvenile justice in Russia is being discussed for a long time in the legal papers and at the legislative level. The provision on the formation of juvenile justice was included in the 1991 Concept of Judicial Reform in the Russian Federation. Later, different authors worked out several draft Laws on Juvenile Justice. At parliamentary hearings in the State Duma, the prospects of creating juvenile courts in the system of courts of general jurisdiction were considered. Meanwhile, such close attention to the indicated problem does not have a significant impact on the increasing child and adolescent crime in the country. The plurality of the above-mentioned legal problems and their multifaceted nature necessitate improvement of justice in relation to minors. This raises a number of theoretical, legal, practical and ethical issues that require studying and adopting relevant decisions at the legislative level. Therefore, studies that allow analyzing the current Russian criminal procedure legislation from the point of view of the possibility of functioning of juvenile justice on its basis relying on international legal standards are really urgent. The criminal procedure legislation in the Russian Federation as a whole is focused on continuous improvement in the context of ensuring the maximum number of procedural guarantees of the legality of criminal proceedings, as well as observance of human rights with the application of their minimum restrictions, including in relation to such category of persons involved in criminal proceedings as minors. In this article, the authors consider the institution of juvenile justice as an additional guarantee of securing the rights of minors in criminal proceedings in Russia, propose the ways to address current and debatable aspects of this problem. The paper analyzes the current criminal procedural legislation, decisions of the Plenums of the Supreme Court of the Russian Federation as well as the judgements of the courts in specific cases concerning the problems of the study. In the study of individual topics of the issue, scientific literature as well as statistical data have been used. The conclusions and proposals made in the work are aimed at improving the current legislation of the Russian Federation and law enforcement practice, and can also be used in the educational process.

Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children and uveitis is its most important extra-articular manifestation. Evidence-based recommendations are available only to a limited extent and therefore JIA associated uveitis management is mostly based on physicians’ experience. Consequently, treatment practices differ widely, both nationally and internationally. Therefore, an effort to optimize and publish recommendations for the care of children and young adults with rheumatic diseases was launched in 2012 as part of the international project SHARE (Single Hub and Access Point for Pediatric Rheumatology in Europe) to facilitate clinical practice for paediatricians and (paediatric) rheumatologists. The aim of this work was to translate published international SHARE recommendations for the diagnosis and treatment of JIA associated uveitis and to adapt them for use in the Czech and Slovak Republics. International recommendations were developed according to the standard methodology of the European League against Rheumatism (EULAR) by a group of nine experienced paediatric rheumatologists and three experts in ophthalmology. It was based on a systematic literature review and evaluated in the form of an online survey and subsequently discussed using a nominal group technique. Recommendations were accepted if > 80% agreement was reached (including all three ophthalmologists). A total of 22 SHARE recommendations were accepted: 3 on diagnosis, 5 on disease activity assessment, 12 on treatment and 2 on future recommendations. Translation of the original text was updated and modified with data specific to the czech and slovak health care systems and supplemented with a proposal for a protocol of ophthalmological dispensarization of paediatric JIA patients and a treatment algorithm for JIA associated uveitis. Conclusion: The aim of the SHARE initiative is to improve and standardize care for paediatric patients with rheumatic diseases across Europe. Therefore, recommendations for the diagnosis and treatment of JIA-associated uveitis have been formulated based on the evidence and agreement of leading European experts in this field.

Abstract Objective This review examines time to access appropriate care for JIA patients and analyses the referral pathway before the first paediatric rheumatology (PR) visit. We also describe factors associated with a longer referral. Methods We performed a systematic literature review, screening electronic databases (PubMed, Web of Science, EMBASE, Cochrane library and Open Grey database) up to February 2020. Articles written before 1994 (i.e. before the introduction of the unifying term JIA) were excluded. Results From 595 nonduplicate citations found, 15 articles were finally included in the review. Most of the studies took place in Europe. The median time to first PR visit ranged from 3 to 10 months, with some disparities between referral pathway and patient characteristics. Patients with systemic-onset JIA had the shortest time to referral. Some clinical and biological factors such as swelling, fever, and elevated CRP and/or ESR were associated with a shorter time to first PR visit. Conversely, enthesitis, older age at symptom onset or pain were associated with a longer time. Whatever the country or world region, and despite disparities in healthcare system organization and healthcare practitioner availabilities, times to access PR were not wide-ranging. Conclusion This is the first systematic review to summarize research on access to PR for JIA patients. The pathway of care for JIA patients remains complex, and reasons for delayed referral depend on several factors. Standardized clinical guidelines and fast-track pathways to facilitate prompt referral to specialized teams have to allow for worldwide disparities in healthcare provision.

Objective.The current Juvenile Idiopathic Arthritis (JIA) Core Set was developed in 1997 to identify the outcome measures to be used in JIA clinical trials using statistical and consensus-based techniques, but without patient involvement. The importance of patient/parent input into the research process has increasingly been recognized over the years. An Outcome Measures in Rheumatology (OMERACT) JIA Core Set Working Group was formed to determine whether the outcome domains of the current core set are relevant to those involved or whether the core set domains should be revised.Methods.Twenty-four people from the United States, Canada, Australia, and Europe, including patient partners, formed the working group. Guided by the OMERACT Filter 2.0 process, we performed (1) a systematic literature review of outcome domains, (2) a Web-based survey (142 patients, 343 parents), (3) an idea-generation study (120 parents), (4) 4 online discussion boards (24 patients, 20 parents), and (5) a Special Interest Group (SIG) activity at the OMERACT 13 (2016) meeting.Results.A MEDLINE search of outcome domains used in studies of JIA yielded 5956 citations, of which 729 citations underwent full-text review, and identified additional domains to those included in the current JIA Core Set. Qualitative studies on the effect of JIA identified multiple additional domains, including pain and participation. Twenty-one participants in the SIG achieved consensus on the need to revise the entire JIA Core Set.Conclusion.The results of qualitative studies and literature review support the need to expand the JIA Core Set, considering, among other things, additional patient/parent-centered outcomes, clinical data, and imaging data.

BackgroundMany people with rheumatic and musculoskeletal diseases (RMDs) experience problems at work and some may even have to stop working due to ill health. In most countries, RMDs are a major cause of worker productivity loss. The peak age of onset of many adult onset RMDs is between ~30-50 years, meaning that the majority of patients are still in employment when diagnosed with their chronic disease. Uncertainty about employment prospects and job attainment is also a major concern for young adults with juvenile idiopathic arthritis (JIA) for whom their first job may influence their future employment prospects. From both a societal and patient perspective it is important to gain an understanding about the impact of juvenile and adult onset RMDs on work outcomes. Data comparing productivity loss with the general population are more relevant for care and healthcare planning. However, these data are more scarce and have not been summarized recently across RMDs.ObjectivesTo systematically summarize the literature on work outcomes in people with RMDs compared with the general population.MethodsA systematic literature review (SLR) was conducted to compare work outcomes in people with various RMDs (i.e. JIA, RA, PsA, AxSpA, SSc, SLE, gout, FM, and OA) with the general population or healthy controls as part of the EULAR Task Force on work. A search for eligible observational studies was performed in Medline, Embase and PsycInfo between 2000 and May 2021. Work outcomes were categorizedaccortding to employment status, work disability/stopped working due to ill health, absenteeism, presenteeism and other.Results541 abstracts were extracted and screened for eligibility. Results of 65 studies fulfilling the inclusion criteria were evaluated for this study, including 28 prospective/retrospective longitudinal cohort studies, 34 cross-sectional studies and 3 (nested) case-control studies. The majority of the studies were conducted in Europe (63.1%). The most common RMD evaluated was RA (26.2%) followed by OA (15.4%), SLE (15.4%), AxSpA (12.3%), FM (9.2%), mixed population (7.7%), JIA (7.7%), PsA (3.1%), SSc (1.5%), and gout (1.5%). In papers reporting disease duration (n=38), the majority of the study population had established disease (76.3%). Several work outcomes were evaluated with some papers reporting more than one work outcome: employment/work status (41.5%), unemployment (9.2%), work disability/pension or stopping work due to ill health (38.5%), absenteeism (52.3%), presenteeism (10.8%), and other (e.g. reduced working hours) (29.2%). Fifty-two papers applied statistical tests (e.g. indirect standardisation, logistic regression analysis, Cox regression analysis) to compare work outcomes in people with RMDs with a control/general population. The percentage of papers reporting the work outcomes to be worse, not significantly different or better in the RMD population compared to the control population (n papers included per work outcome; %) was, respectively: employment/work status (n=26; 73.1%, 23.0%, 3.8%), unemployment (n=6; 66.7%, 33.3%, 0%), work disability/stopping work (n=22; 90.9%, 9.4%, 0%), absenteeism (n=26; 92.3%, 7.7%, 0%), presenteeism (n=8; 87.5%, 12.2%, 0%), other (n=19; 84.2%, 15.8%, 0%).ConclusionDespite better disease management during the last two decades there is still a significant employment gap between people with RMDs and the general population. It is therefore essential that health professional organisations, policy makers, patient organisations and employers should collaborate to minimize the employment gap and optimize employment opportunities among people with juvenile and adult onset RMDs.Disclosure of InterestsSuzanne Verstappen Consultant of: EUOSHA, Grant/research support from: BMS, AbbVie, Pfizer, EULAR, Annelies Boonen Speakers bureau: Abbvie / Galapagos, Consultant of: Galapagos, Nicola Goodson Consultant of: UCB, Lilly, Abbvie, Novartis and Janssen, Grant/research support from: Novartis, Casper Webers: None declared, Maarten Butink: None declared, Neil Betteridge Consultant of: Amgen, Eli Lilly, EULAR, GAfPA, Grunenthal, Heart Valve Voice and Sanofi, Tanja Stamm Consultant of: AbbVie and Sanofi Genzyme, Grant/research support from: AbbVie and Roche, Dieter Wiek: None declared, Anthony Woolf: None declared, Hans Bijlsma: None declared, Gerd Rüdiger Burmester: None declared

In Europe, 82% of minors use a social network (SN). Although SNs offer opportunities for social interaction, they also involve some risks, such as online sexual victimization (OSV). As many as 39% of teenagers are estimated to be at risk of OSV. The literature suggests that risky online behaviors, such as sexting, indiscriminate expansion of SNs, and intimate and face-to-face relationships with strangers met online, can increase the risk of OSV among adolescents. The aim of the study was to investigate the prevalence of OSV and related risk factors in a sample of early adolescents. A cross-sectional study was conducted based on 310 Italian adolescents (12–14 years old) who completed the Juvenile Online Victimization Questionnaire (JOV-Q). Sixty percent of the sample reported at least one form of OSV, with males more at risk than females. Age, gender, and online risk behaviors are predictors of different kinds of OSV. In the whole sample, the most frequent kind of OSV was unwanted exposure to sexual content, followed by sexual pressure, online grooming, and sexual coercion. Sexting and indiscriminate expansion of one’s network increase the likelihood of having been the target of at least 1 OSV in the past year. Early adolescents can face a higher risk of OSV than adolescents, based on known percentages. The study of the prevalence and risk factors in this age group therefore deserves specific attention in order to design programs to prevent and combat OSV.

The North American terrapin, the red-eared slider, has globally recognized invasive status. We built a new extensive database using our own original and literature data on the ecology of this reptile, representing information on 1477 water bodies throughout Eurasia over the last 50 years. The analysis reveals regions of earliest introductions and long-term spatio-temporal dynamics of the expansion covering now 68 Eurasian countries, including eight countries reported here for the first time. We established also long-term trends in terms of numbers of terrapins per aquatic site, habitat occupation, and reproduction success. Our investigation has revealed differences in the ecology of the red-eared slider in different parts of Eurasia. The most prominent expression of diverse signs of invasion success (higher portion of inhabited natural water bodies, higher number of individuals per water body, successful overwintering, occurrence of juvenile individuals, successful reproduction, and establishment of populations) are typical for Europe, West Asia and East Asia and tend to be restricted to coastal regions and islands. Reproduction records coincide well with the predicted potential range based on climatic requirements but records of successful wintering have a wider distribution. This invader provides an excellent and possibly unique (among animals) example of wide alien distribution, without the establishment of reproducing populations, but through the recruitment of new individuals to rising pseudopopulations due to additional releases. Therefore, alongside the potential reproduction range, a cost-effective strategy for population control must take in account the geographical area of successful wintering.

The strong decline of freshwater fish species in Europe implies that further ex-situ conservation plans should be implemented in the near future. The present study reflects our experience with the Pyrenean sculpin (Cottus hispaniolensis Bacescu-Mester, 1964)—a small cottid endemic to the Hispano-French Garona River basin. In recent years, the Spanish Pyrenean sculpin population has reached a limit situation. Because of that, the non-profit association ADEFFA—with support from the public administration—started the first captive breeding program for this species in 2006. Fourteen years later, this study presents the results and evaluates the different steps of the program, with the aim of discussing and improving the ex-situ conservation plans for this and other cold freshwater species. There is a description and a comparison between six consecutive phases during the captive breeding process: nesting behaviour, courtship, egg fixation, parental care (incubation), hatching and survival during juvenile development. The purposes of this project are to: (1) identify the most determining phases for a successful captive breeding; (2) identify the factors that had a major influence to the success of the critical phases; and (3) increase the number of the offspring. This study is based on thirty-three wild individuals collected from Garona River (Val d’Aran, Spanish Pyrenees). During the program, twelve couples spawned in captive conditions, with around 2300 eggs laid. Eight couples bred successfully, with 751 hatched individuals and 608 juveniles reared. The analysis of each step of the captive breeding does not reveal significant differences between phases, so it can be concluded that they are all critical at the same level. In the literature, similar study-cases of captive breeding programs identify incubation and survival phases as the most critical. Consequently, the management made for this project has probably allowed to overcome in part the main impediments described in other similar programs.

BackgroundDermatomyositis (DM) and polymyositis (PM) are rare heterogenous systemic autoimmune disorders of the skin, muscles, and other organs with few effective treatment options available. They are described as devastating diseases but the full impact on patients’ lives in Europe is not well understood.ObjectivesTo systematically review and summarize evidence on humanistic burden of disease in patients with DM and PM in Europe to better understand patient-relevant aspects of disease and key domains of life impacted by DM and PM in the European setting.MethodsA systematic literature review (SLR) was conducted in MEDLINE and Embase databases to identify studies in children and adults with DM and PM, published in the English language between Jan 1, 2011, and Apr 28, 2021. Only primary studies enrolling 10 or more patients were included, irrespective of country or region. Each eligible article was independently reviewed by two reviewers. The title and study abstracts were reviewed to assess eligibility for full-text review. The topics of interest were clinical, humanistic, and economic burden of disease, as well as current management and unmet needs in DM and PM. Information on geographic scope was extracted from the papers of included studies. The current abstract summarizes SLR results on humanistic burden of DM and PM in European patients.ResultsA total of 2,967 non-duplicated publications were retrieved from medical databases and analyzed against pre-defined study selection criteria. There were 2,574 records excluded at title and abstract screening. Remaining 393 records were analyzed in the full text with 208 papers considered relevant. Additional 21 papers were identified from searching reference list of relevant studies and conference proceedings. In total, 222 studies described in 229 publications were included in data abstraction. Among 43 studies conducted across 14 European countries, 12 studies evaluated health-related quality of life (HRQoL) and work productivity in patients with DM and PM. In 6 studies, patients received standard of care therapy. Six studies enrolled adults with DM and PM and 6 were conducted in patients with juvenile onset of DM. There were 6 cross-sectional analyses, 4 longitudinal cohort studies, 2 case-control studies, with sample size ranging from 11 to 246 patients. Adults with DM and PM had significantly worse HRQoL across multiple domains of 36-Item Short Form Survey (SF-36) compared to controls from general population, with a strong negative impact of muscle weakness on physical functioning. Patients reported high difficulties in performing leisure time activities, moving around and work as indicated by median scores of 4-5 points in a 7-point Myositis Activity Profile (MAP). Reduced grip force in DM and PM adults was significantly associated with worse performance in domestic activities in the MAP assessment (p<0.05). In women with DM and PM, poor grip force additionally impacted vitality and mental health as measured by SF-36 (p<0.05). There were no associations between grip force and any SF-36 domain in men. Approximately 60% of adult patients rated their ability to work as “poor” or “less good” according to the Work Ability Index, 68% of patients had more than one week of sick leave in the past year, and 20.8% of them were permanently not able to work for at least 2 years. Children and adolescents with DM had impaired physical and psychosocial functioning compared to healthy norms with 40% of individuals showing increased emotional distress requiring in-depth psychological assessment.ConclusionEuropean patients with DM and PM experience a muscle weakness that has a detrimental impact on HRQoL, daily activities and ability to work. Similar disease impact on HRQoL was reported in patients in North America. These findings suggest a need for a novel therapy that will restore physical functioning in patients with DM and PM.Disclosure of InterestsJens Schmidt Speakers bureau: Euroimmun, CSL Behring, Consultant of: Alnylam, Argenx, Biotest, CSL Behring, Kezar Life Sciences, LFB, Novartis, Octapharma, UCB, Grant/research support from: CSL Behring, Novartis, Konrad Pisarczyk Consultant of: Kezar Life Sciences, Richard Leff Shareholder of: Kezar Life Sciences, Consultant of: Kezar Life Sciences, Kiruthi Palaniswamy Shareholder of: Kezar Life Sciences, Employee of: Kezar Life Sciences, Eunmi Park Shareholder of: Kezar Life Sciences, Employee of: Kezar Life Sciences, Li Long Shareholder of: Kezar Life Sciences, Employee of: Kezar Life Sciences

Introduction. The definition of criteria for separating closely related species of representatives of the genus Cythereis is currently incomplete. Ostracods of this genus have wide intraspecific variability and high adaptability to changing living conditions. These factors make it difficult to use these ostracod species for regional stratigraphic correlation. In addition to the selection of criteria for species separation, there is a problem of the imperfection of the terminological apparatus for describing ostracods, which complicates the description of species and omits potentially important information for the separation of related species. Analysis of previous publications. Numerous works are devoted to the issue of the development of the terminological apparatus for describing ostracods, however, qualitative methods of description are inherent only to certain large taxa, where a separate method of description has been developed for each taxon. Ostracods of the genus Cythereis are widespread in the Cretaceous Tethys. Their wide variability is considered by various authors often without taking into account intraspecific variability and adaptation, which leads to the selection of subspecies or ignoring variability. Materials and methods. Numerous ostracods of the species Cythereis hirsuta Damotte&Grosdidier from the Late Cenomanian and Cythereis ornatissima (Reuss) from the Turonian of Ukraine were used in the work. Ostracods were selected from different deposits according to the conditions of origin. Results and discussion. The paper describes in detail the morphology of ostracods of the genus Cythereis with qualitative characteristics of morphological elements. The ontogenetic changes of the two species and the change in morphology depending on the conditions of existence are also described. The change in the morphology of juvenile forms depending on the conditions of existence is described separately. Conclusions. Based on the study and description of numerous paleontological materials, a number of refinements were proposed to the descriptive characteristics of the morphological elements of ostracod valves of members of the family TRACHYLEBERIDINAE Sylvester-Bradley, 1948 and the genus Cythereis in particular. The proposed clarifications regarding the morphology of the mesosculpture made it possible to describe in detail the ontogenetic changes of the studied species and their differences in adult stages depending on the facial conditions of existence. It should be noted that a detailed scheme for describing the morphology of mesosculpture is proposed for the first time in the literature. The paleontological description of numerous materials from the Middle Cretaceous of Ukraine allowed to establish the morphological elements that are of primary importance for the separation of related species within the genus. The analysis of these elements suggests that some of the similar species from the outcrops of Europe and Asia are actually other species. The question of their phylogenetic ties can be solved under the condition of studying ontogenesis and expanding the geography of research. Based on this, the validity of the names of the studied species from the territory of Ukraine is also contradictory to the actual comparison with the holotype collection.

Родовой комплекс Robinia L. представляет большой интерес для мобилизации генетических ресурсов в аридные регионы Европы, Азии и Северной Америки. Различные темпы расширения культигенных ареалов некоторых видов рода RobiniaL. несомненно связаны с особенностями их адаптации и жизненными стратегиями выживания в новых условиях существования. В связи с этим, целью данной работы являлся анализ механизмов адаптации и жизненных стратегий различных видов рода Робиния в условиях интродукции. Объектами исследований стали виды и формы родаRobinia L.: R. neomexicana Gray. (syn. Robinia luxurians (Dieck.) C. K. Shneid.); R. pseudoacacia L.; R. pseudoacacia f. pyramidalis (Pepin) Rehd.; R. pseudoacacia f. umbraculifera (DC) Rehd.; Robinia viscosa Vent. var. hartwegii (Koehne) Ashe, произрастающие в кластерных коллекционных участках ФНЦ агроэкологии РАН, кадастр №34:34:000000:122, 34:34:060061:10. Проведенные исследования позволили выявить у различных представителей родаRobinia L. целый ряд филогенетических адаптаций к воздействию неблагоприятных факторов среды, таких как сильно разветвленная корневая система, ксероморфное строение листьев, ажурность и ветропроницаемость крон, способность переносить продолжительные засухи, симбиотические связи с азотфиксирующими бактериями. Результаты исследований показали, что в процессе интродукции все виды рода Robinia L. используют ряд фенотипических онтогенетических приспособлений. Наиболее важные из них – это смена жизненной формы (дерево - кустарник, одноствольное - многоствольное дерево), а также снижение темпов роста и уменьшение общей высоты растений в зависимости от почвенного плодородия, влагообеспечения и повреждающего воздействия низких зимних температур. Так, на обыкновенных черноземах в условиях Украины в возрасте 20-и лет насаждения из Робинии псевдоакации достигают высоты 14-15 м, тогда как на светло-каштановых почвах в условиях Нижнего Поволжья в этом же возрасте они достигают всего 6 м. Кроме этого, на протяжении последних столетий представители рода Robinia L. выработали ряд генотипических адаптации к новым условиям существования. Данные приспособления являются одними из самых важных, т.к. приводят к появлению качественно новых адаптаций, расширяющих границы экологической пластичности вида. У всех видов сократились сезонные циклы фенологического развития и в настоящее время они укладываются в оптимальные сроки развития древесных интродуцентов в регионах с относительно суровым для них климатом. По показателю фенологической атипичности в условиях Нижнего Поволжья они находятся в нижней половине области нормы (от +1 до 0) по реализации фенологических фаз, что свидетельствует от том, что цикл их развития успешно адаптировался и соответствует вегетационному периоду места интродукции. Как показали наши исследования, все виды рода Robinia L. в процессе акклиматизации, перешагнула температурный порог в - 37°С. Генотипическую природу сформировавшихся адаптаций к низким зимним температурам доказывает сравнительный анализ литературных данных по морозостойкости различных видов рода Robinia L. полученных в начале XX века с данными визуальных и физиологических методов оценки проведенных на протяжении последних десятилетий. Вторым важным доказательством появления адаптаций, закрепленных на генетическом уровне является разница в зимостойкости между формами R. pseudoacacia f. pyramidalis (Pepin) Rehd., R. pseudoacacia f. umbraculifera (DC) Rehd. и типичными представителями R. pseudoacacia L. Отсутствие генетической неоднородности при вегетативном размножении указанных форм остановило процессы микроэволюции, не позволив им адаптироваться в новых условиях существования. Анализ жизненных (экологических) стратегий показал, что в растительных сообществах Робиния псевдоакация может с одинаковым успехом выступать в роли патиента или эксплерента. При этом виалентные свойства у нее выражены намного слабее. Анализ r/K стратегий выживания позволяет отнести ее к r-видам, с высоким генеративным потенциалом, коротким ювенильным и виргинильным этапом развития, способностью к натурализации. Однако, в оптимальных условиях существования в отсутствии конкуренции она, как и многие К-виды может достигать значительного возраста до 400 лет. Все виды рода Robinia L. способны к натурализации в тех или иных регионах вторичного ареала. Однако рекордсменом по этому показателю несомненно является Робиния псевдоакация. По нашему мнению, данный факт объясняется высоким генеративным потенциалом R. pseudoacacia L. по отношению к родственным видам и его высокой хозяйственной значимостью для целей лесозащитного разведения. Представители рода Robinia L. не имеют приспособлений для активного распространения семян на значительные расстояния. Натурализация (вхождение в естественные растительные сообщества) происходит, как правило, в непосредственной близости от искусственных лесозащитных насаждений. Розовоцветковые виды рода Robinia L., ввиду небольшого роста, не представляют особого интереса для целей агролесомелиорации. Данные виды используются обычно в озеленении населенных пунктов как декоративные растения. Искусственная территориальная изоляция от естественных растительных сообществ и относительно низкий генеративный потенциал не позволяют им активно проявлять инвазивные свойства. The Robinia L. genus is of great interest for mobilizing genetic resources in arid regions of Europe, Asia, and North America. The different rates of expansion of cultigen areasof some species of the Robinia L. genus are undoubtedly related to the peculiarities of their adaptation and life strategies for survival in new conditions of existence. In this regard, the purpose of this work was to analyze the mechanisms of adaptation and life strategies of various species of the Robinia genus under the conditions of introduction. The objects of research were species and forms of the Robinia L. genus: R. neomexicana Gray. (syn. Robinia luxurians (Dieck.) C.K. Shneid.); R. pseudoacacia L.; R. pseudoacacia f. pyramidalis (Pepin) Rehd.; R. pseudoacaciaf. umbraculifera (DC) Rehd.; Robinia viscosa Vent. var. hartwegii (Koehne) Ashe, growing in cluster collection sites of the Federal Centerfor Agroecology of the Russian Academy of Sciences, cadastre No. 34:34:000000:122, 34:34:060061:10. Studies have revealed a number of phylogenetic adaptations to adverse environmental factors in various members of the Robinia genus, such as a highly branched root system, xeromorphic structure of leaves, opennessand wind permeability of crowns, the ability to tolerate prolonged droughts, and symbiotic relationships with nitrogen-fixing bacteria. The research results have shown that all species of the Robinia L. genus use a number of phenotypic ontogenetic devices during introduction. Among them, the most important ones are the change of life form (tree – shrub, single-trunk tree – multi-trunk tree), as well as a decrease in growth rates and a decrease in the overall height of plants, depending on soil fertility, moisture supply, and the damaging effects of low winter temperatures. For example, on ordinary chernozems in Ukraine at the age of 20 years, plantings ofRobinia pseudoacacia reach a height of 14-15 m, while on light chestnut soils in the Lower Volga region at the same age, they reach only 6 meters. In addition, over the past centuries, representatives of the Robinia L. genus have developed a number of genotypic adaptations to new conditions of existence. These adaptations are among the most important ones, because they lead to the appearance of qualitatively new adaptations that expand the boundaries of ecological plasticity of the species. All species have reduced their seasonal cycles of phenological development and currently meetthe optimal time frame for the development of introduced trees in regions with a relatively harsh climate for them. According to the indicator of phenological atypicality, they are in the lower half of the normal range (from +1 to 0) in terms ofthe implementation of phenological phases, which indicates that the cycle of their development has successfully adapted and corresponds to the vegetation period of the place of introduction. As shown by the authors’research, all species of the Robinia L. genus in the process of acclimatization crossed the temperature threshold of –37°C. The genotypic nature of the formed adaptations to low winter temperatures is proved by a comparative analysis of the literature data on the frost resistance of various species of the Robinia L. genus obtained at the beginning of the 20thcentury with the data of visual and physiological assessment methods conducted over the past decades. The second important proof of the appearance of adaptations fixed at the genetic level is the difference in winter hardiness between the forms of R. pseudoacacia f. pyramidalis (Pepin) Rehd.; R. pseudoacacia f. umbraculifera (DC) Rehd. and typical representatives of R. pseudoacacia L. The absence of genetic heterogeneity in the vegetative reproduction of these forms of Robinia stopped the processes of microevolution, not allowing them to adapt to the new conditions of existence. Analysis of life (environmental) strategies has shown that in plant communities,Robiniacan equally well act as a patient or an explerent. At the same time, the violent properties of Robinia are much less pronounced. Analysis of r/K survival strategies allows classifying it as an r-species with high generative potential, short juvenile and virginal stages of development, and the ability to naturalize. However, in optimal conditions of existence in the absence of competition, Robinia, like many K-species, can reach a significant age of up to 400 years. All Robinia species are capable of naturalization in certain regions of the secondary range. However, the record holder for this indicator is undoubtedly Robiniapseudoacacia. In the authors’opinion, this fact is explained by the high generative potential of R. pseudoacacia L. in relation to related species and its high economic significance for the purposes of forest protection breeding. Representatives of the Robinia L. genus do not have adaptations for active seed propagation over long distances. Naturalization (entering natural plant communities) usually occurs in the immediate vicinity of artificial forest protection stands at a distance. Pink-flowered species of the RobiniaL.genus,due to their small growth, are not of particular interest for agroforestry purposes. These types are usually used in landscaping settlements as ornamental plants. Artificial territorial isolation from natural plant communities and relatively low generative potential do not allow them to actively exhibit invasive properties.

By definition, a monument has extraordinary features that mark landscape and human minds alike. Without any doubt, the Medieval and Early Modern World of Europe was marked by ecclesiastical monuments, from great cathedrals and abbeys to simple chapels and altars at crossroads. A very interesting case study offers Braşov/ Kronstadt/Brassó, in the south-eastern corner of Transylvania, where historical sources attest several ecclesiastic monuments, in and around the city. Late medieval and early modern documents and chronicles reveal not only interesting data on the monasteries, churches and chapels of Braşov/Kronstadt/Brassó, but also on the way in which citizens and outsiders imagined those monuments in their mental topography of the city. The inhabitants of Braşov/ Kronstadt/Brassó and foreign visitors saw the monasteries, churches and chapels of the city, kept them in mind and referred to them in their (written) accounts, when they wanted to locate certain facts or events. The present paper aims in offering an overview of the late medieval and early modern sources regarding the ecclesiastical monuments of Braşov/Kronstadt/Brassó, as well as an insight into the imagined topography of a Transylvanian city.

Myasthenia gravis (MG) appears to have a similar incidence among adult populations worldwide. However, epidemiological and phenotypic differences have been noted among children and juveniles with MG. We reviewed the literature on childhood- and juvenile-onset MG among different populations, with the focus on ocular involvement, antibody profiles, the genetic susceptibility to juvenile MG phenotypes, the use of immune treatments, and the reported responses of extraocular muscles to therapies. Although epidemiological studies used different methodologies, reports from Asia, compared to Europe, showed more than two-fold higher proportions of prepubertal onset (before 12 years) vs. postpubertal-onset juveniles with MG. Compared to European children, ocular MG was 4-fold more frequent among Asian children, and 2–3-fold more frequent among children with African ancestry both in prepubertal and postpubertal ages at onset. These results suggest genetic influences. In Asia, HLA-B*46 and DRB1*09 appeared overrepresented in children with ocular MG. In Europe, children with MG had a significantly higher rate of transforming from ocular to generalized disease and with an overrepresentation of HLADRB1*04. Although treatment regimens vary widely and the responses to immune therapies of the ocular muscles involved in MG were generally poorly described, there were indications that earlier use of steroid therapy may have better outcomes. Reports of treatment-resistant ophthalmoplegia may be more frequent in African and Asian juvenile MG cohorts compared to Europeans. Genetic and muscle gene expression studies point to dysregulated muscle atrophy signaling and mitochondrial metabolism pathways as pathogenetic mechanisms underpinning treatment-resistant ophthalmoplegia in susceptible individuals. In conclusion, phenotypic differences in juveniles with ocular manifestations of MG were evident in different populations suggesting pathogenetic influences. Treatment responses in MG-associated ocular disease should attract more careful descriptive reports. In MG, extraocular muscles may be vulnerable to critical periods of poor force generation and certain individuals may be particularly susceptible to developing treatment-resistant ophthalmoplegia. The development of prognostic biomarkers to identify these susceptible individuals is an unmet need.

IntroductionJuvenile-onset systemic lupus erythematous (JSLE) is a rare multisystem autoimmune disorder. In 2012, the Single Hub and Access point for pediatric Rheumatology in Europe (SHARE) initiative developed recommendations for the diagnosis/management of JSLE, lupus nephritis (LN) and childhood-onset anti-phospholipid syndrome (APS). These recommendations were based upon available evidence informing international expert consensus meetings.ObjectiveTo review new evidence published since 2012 relating to the management of JSLE, LN and APS in children, since the original literature searches informing the SHARE recommendations were performed.MethodMEDLINE, EMBASE and CINAHL were systematically searched for relevant literature (2012-2021) using the following criteria: (1) English language studies; (2) original research studies regarding management of JSLE, LN, APS in children; (3) adult studies with 3 or more patients &lt;18-years old, or where the lower limit of age range ≤16-years and the mean/median age is ≤30-years; (4) randomized controlled trials (RCTs), cohort studies, case control studies, observational studies, case-series with &gt;3 patients. Three reviewers independently screened all titles/abstracts against predefined inclusion/exclusion criteria. All relevant manuscripts were reviewed independently by at least two reviewers. Data extraction, assessment of the level of evidence/methodological quality of the manuscripts was undertaken in-line with the original SHARE processes. Specific PUBMED literature searches were also performed to identify new evidence relating to each existing SHARE treatment recommendation.ResultsSix publications met the inclusion/exclusion criteria for JSLE: three RCTs, one feasibility trial, one case series. For LN, 16 publications met the inclusion/exclusion criteria: eight randomized trials, three open label prospective clinical trials, five observational/cohort studies. For APS, no publications met the inclusion criteria. The study with the highest evidence was an RCT comparing belimumab vs. placebo, including 93 JSLE patients. Whilst the primary-endpoint was not met, a significantly higher proportion of belimumab-treated patients met the PRINTO/ACR cSLE response to therapy criteria. New evidence specifically addressing each SHARE recommendation remains limited.ConclusionSince the original SHARE literature searches, undertaken &gt;10-years ago, the main advance in JSLE treatment evidence relates to belimumab. Additional studies are urgently needed to test new/existing agents, and assess their long-term safety profile in JSLE, to facilitate evidence-based practice.

Background. Juvenile nasal angiofibroma (JNA) is a very rare benign lesion originating from the pterygopalatine fossa with distinctive epidemiologic features and growth patterns. The typical patient is an adolescent male with a clinical history of recurrent severe nasal bleedings and blockage the nose. Currently, even though surgery often caused severe operative bleeding, it is considered the ideal treatment for JNA. Refinement in preoperative embolization, which provides significant reduction of intraoperative bleeding. In spite of breakthrough of Endoscopic techniques which minimize the risk of residual disease, the search of new devises which can help to management of JNA is still continue in order to minimize the surgical complications. Laser methods as surgical treatment have been actively used in rhinology during the past decades. We purposed to summarize information about current lasers and their use in rhinology. Aim. The purpose of the study is the literature review and to describe our experience of using new blue laser during JNA removal. Evaluation of advantages and disadvantages, determination of indications and limits of its use in rhinosurgery Methods- A literature review from 2000 to 2022 using the PubMed database was employed. Keywords used included “laser surgery”, “blue light laser”, “photoangiolytic laser”, “laser in rhinosurgery”. The most up to date studies published for each rhinology condition that was treated with laser surgery was reviewed. Then endoscopic removal through the nose was performed. During the surgery TrueBlue laser was used to cut the tissues and coagulate injured vessels. Results. Rhinological conditions appropriate for laser applications are discussed. There are related papers to a number of applications including hereditary hemorrhagic telangiectasia, rhinitis, turbinate surgery, dacryocystorhinostomy, septoplasty, choanal atresia, and sphenopalatine artery ligation, paying attention to the outcomes of the studies. It is the first experience of using blue laser in rhinosurgery and particulary ib removing JNA. Conclusion. Intranasal laser surgery, despite the fact that interventions are performed almost bloodlessly, and often do not require nasal tamponade, indications for their performance are limited, due to deep burns of the nasal mucosa, and alteration of mucociliary clearance therefore lasers are not so often used in rhinology. The short-wave blue laser with a wavelength of 445 nm, used in Europe in oto- and laryngosurgery, may have some potential advantages in rhinosurgery, but the practical dataset are limited yet.

Abstract Wooden shingles have been known in Europe and other regions worldwide for several thousands of years. They are usually split, and according to handicraft rules, as well as historical literature, a split surface has many advantages. It is more flexible, more elastic, stronger, and less exposed to cupping than a sawn surface because no fibers have been cut. It also follows wood rays; it is more durable than a sawn surface because cut fibers absorb more moisture, creating good conditions for fungal growth. However, because sawing is the main procedure for dividing logs into timber, sawn boards are currently used for roofing. The short life span of such roofing has often been discussed by craftsmen. In this study, a 37-year-old roofing was evaluated to determine the important parameters of high-durability sawn boards. Results showed that the presence of juvenile wood, fiber deviations, and knots reduced the durability of these boards. Therefore, sawn boards of the same wood quality as split shingles may have the same durability.

AbstractThe anadromous European smelt (Osmerus eperlanus) plays a key role in food webs of many riverine ecosystems in Europe. However, population sizes in several German rivers (e.g. Elbe or Weser rivers) have diminished drastically over the past decade. Turbidity has been considered one of the stressors affecting the successful recruitment of European smelt, as their early life stages may be particularly sensitive to changes in the abiotic environment. In this study, we investigated whether prey consumption and survival of European smelt larvae would be negatively affected by an acute exposure to elevated turbidity. We reared the larvae in the laboratory and exposed them in four separate trials (18 to 26 days post hatch, 9.5 ± 0.8 mm standard length, mean ± SD) to six turbidity levels (0–500 NTU, nephelometric turbidity units). We found that prey uptake increased at low turbidity levels and decreased at high turbidity levels, with an optimum between 100 and 200 NTU. Survival started to decrease at turbidity levels above 300 NTU. In addition, we conducted a systematic literature analysis in which we found that prey consumption of larval and juvenile fishes had been tested across a wide range of turbidity levels, mostly using pelagic (e.g. planktonic) prey items, with more studies focusing on perciform fishes and juvenile rather than larval life stages. Our empirical findings contribute to establishing thresholds for optimal larval European smelt performance under increased turbidity and provide valuable information for developing mechanistic models that assess potential consequences for European smelt recruitment dynamics.

AbstractEmys orbicularis is receding from Europe, mainly due to anthropogenic habitat changes. Its parasite, Placobdella costata, is widely distributed within both the former and the present distribution range of the host. Though closely associated with the mud turtle, it may have other hosts (birds, amphibians, reptiles). Its reproductive period coincides with that of its host’s migration to the breeding grounds, thus facilitating dispersal of the parasite. Based on literature data we have analyzed the geographic spread of P. costata and mud turtle to observe the possible overlap of their habitats. Observations on the population of mud turtle and the associated leech species (P. costata) were carried out in eastern Poland — Podlasie Lowland. The studies were conducted in spring and summer in 1986–1993. The leeches were collected from the turtles caught in the water and on land. Observations showed that most leeches were found on turtles inhabiting the lake or moving to a breeding area. The greatest intensity of invasion was observed in June and July and that most leeches were observed in female E. orbicularis characterized by greater length of the carapace and weight, compared with males and juvenile individuals.

The Sakarya Zone of northern Turkey contains a well-preserved Early−Middle Jurassic and Late Cretaceous submarine magmatic arc constructed over pre-Jurassic bedrocks that are considered to be the eastward extension of the Armorican Terrane Assemblage in Europe. In this study, we present U-Pb-Hf isotopic data from the detrital zircons of middle Permian and Lower Jurassic sandstones to reveal episodes of Paleozoic−early Mesozoic magmatic flare-ups. Detrital zircon ages, together with data from the literature, define three major age groups at 400−380 Ma, 326−310 Ma, and 250−230 Ma, which indicates three distinct magmatic flare-ups. In addition, there are minor age clusters at 460−430 Ma and 215−195 Ma. Initial εHf values of the detrital zircons indicate significant juvenile input during the Triassic flare-up, the involvement of significantly reworked crustal material during the late Carboniferous magmatic flare-up, and both juvenile and reworked crustal material during the Middle Devonian magmatic flare-up. Within the pre-Jurassic continental basement rocks of the Sakarya Zone, the late Carboniferous igneous rocks are well documented and most voluminous, and the Middle Devonian rocks are known locally, while the Triassic igneous rocks—apart from those in Triassic accretionary complexes—are hardly known. Because the Sakarya Zone is a Gondwana-derived continental block that was later involved in the Variscan and Alpine orogenies, these magmatic flare-ups cannot be explained by subduction-related processes along a single subduction zone. We propose that the Sakarya Zone rifted from the northern margin of Gondwana during the Late Ordovician−Silurian, the Devonian magmatic flare-up (400−380 Ma) was related to the southward subduction of the Rheic Ocean beneath the Sakarya Zone during its northward drift, the late Carboniferous magmatic flare-up (326−310 Ma) occurred following the collision of the Sakarya Zone with Laurussia, and the Triassic flare-up (250−230 Ma) resulted from northward subduction of the Tethys Ocean beneath the Sakarya Zone. Comparison with data from the literature shows that the Triassic and late Carboniferous magmatic flare-ups are also characteristic features of neighboring Armorican domains, such as the Balkans and the Caucasus; however, the Middle Devonian flare-up appears to be restricted to the Sakarya Zone. Along with the late Carboniferous flare-up, the Late Ordovician−Silurian flare-up, which is locally recorded in the Sakarya Zone, is typical of the Armorican Terrane Assemblage as a whole.

The United Nations defines the Human Rights as the rights of all human beings, regardless of race, gender, language, religion, nationality, or any other status. These rights include all claims to live freely, to educate and work in equality, and to inhabit humanistic urban and architectural spaces. Throughout the history of architecture, civilisations have generated different perspectives towards respecting the human rights. Temples of Ancient Egyptian Architecture crushed the human scale to introduce religious experiences to their visitors. Tibetan temples over mountains enforced people to make anti-humanistic journeys to reach them. After thousands of years, the mega-scale palaces and cathedrals in the Gothic era underestimated the human scale due to the powerful rule of Church in Europe. On contrary, pioneers of Renaissance Era made an intellectual revolution to respect humanism through humane proportions. After a while, the Industrial Revolution employed all materials, machines, and sciences to serve humanism. Architectural projects therefore fulfilled the physical without covering the spiritual and emotional human needs. This remained until 1960s when the postmodern architecture emerged. Nowadays, several architectural projects have unfortunately neglected achieving equality for all categories of users. Critics, such as Jane Jacobs 2000, have pointed out that a number of starchitects - pioneers of the architectural world - have designed anti-humanistic spaces. Within the onslaught of digitization, deconstruction, and free forms, some architects have celebrated the power of building technology in designing non-traditional compositions, disregarding the humane essence. These uncanny forms have missed the feeling of humane dimension. This research aims to investigate the relationship between architecture and human rights, trying to propose a new architectural manifestation putting the human rights as the first priority. In order to achieve this aim, the paper followed scientific methods, starting by literature review defining the meaning of human rights, its values, and its relation to the humane architecture. To collect this data, the authors depended on desk research and reviewed previous readings to highlight the examples that put the humane factor at the first place as the main design-concept. A deep analysis for two case studies has been conducted, based on observations, photos, and documentation. Authors experienced these two projects during personal site visits. The analysis detected the architectural representations of humane design in both projects. A comparison between the case studies presented the most important elements and features that their architects were keen to apply. The research concludes that architecture and human rights are inseparable, and the design of human space needs a symphony of multiple tasks and elements including specific materials, meaningful spaces, and advanced technology.

Abstract Background/Aims Juvenile-onset systemic lupus erythematosus (JSLE) is a rare autoimmune disorder that causes multisystem damage. Paucity of data limits the evidence upon which to base recommendations for diagnosis, monitoring, and management of JSLE. JSLE patients often present more acutely, with more severe complications and greater need for corticosteroids and disease-modifying therapies earlier in life when compared to those with adult-onset SLE (aSLE). The SHARE initiative generated a set of guidelines to standardise JSLE care across Europe. This aim was to undertake a comprehensive comparison aimed at comparing the SHARE guidelines to those developed by the BSR (for aSLE) to identify similarities, differences, and areas in which more research was needed. Methods The SHARE evidence-based, consensus-derived recommendations were established by a European wide panel of paediatric rheumatologists according to EULAR standard operating procedures using a systematic literature search with strict inclusion criteria. Adult-derived evidence was included when lack of paediatric literature existed but reviewed to adapt adult guidelines to be more suitable for paediatric use. The BSR guidelines built upon existing EULAR guidelines, selecting specific recommendations by prioritisation. Both SHARE and BSR used the same method of validating guidelines using Level of Evidence, grade of recommendation and strength of agreement by the panel (SOA) to support their recommendations. A systematic comparison was performed by identifying specific subgroups of recommendations related to: diagnosis, background, neuropsychiatric and monitoring and management guidelines. These subgroups were then compared by assessing the number of guidelines related to each group and the average SOA for each. A detailed comparison into the specific guidelines was then performed to provide in depth analysis of the similarities and differences between the groups and identify areas missing and where more work was needed. Results There are many similarities between the two sets of recommendations. Although some of these are a result of the manifestations being the same in adults and children, a significant proportion of these similarities were due to the lack of background data to base recommendations on for JSLE. Therefore, adult-derived guidelines, particularly the EULAR guidelines have been used which were also used as background for BSR recommendations. A key difference was the lack of recommendations regarding neuropsychiatric manifestations (NP-aSLE) in adult-onset disease. A detailed comparison between individual guidelines has been generated and potential reasons for the discrepancies between the guidelines identified. Conclusion The results demonstrate the need for significantly more research to inform generation of more specific JSLE guidelines, particularly in management of the disease manifestations specific to children. Many similarities between these adult and paediatric guidelines underline the importance of generating common guidelines where possible for JSLE and aSLE. More work is needed in NP-aSLE to produce more balanced generalised results. Disclosure T.E. Kelly: None. M.W. Beresford: None.

Introduction: Suicide is a serious world public health problem and still an interesting, controversial and difficult subject for theoretical and empirical considerations. Aim: The aim of this paper is to present the prevalence of suicide in Poland in context of suicidal situation worldwide. Material and methods: This article is based on the available literature, National Polish Headquarters reports and World Health Organization data. Results and discussion: Many publications on suicide to date focus on showing the correlation between the suicide act and age, gender, social background, education, place of residence, marital status, season, climate, day of the week, and even a daily cycle. Profiles of a potential suicide are created. Suicide is the most serious cause of death among patients with mental disorders. However, scientific reports among people who commit suicide and attempt suicide also mention people, who are not mentally ill. There is no medical suicide reporting and analysis system in Poland. The National Police Headquarters publish annual report containing the number of suicides committed in Poland. Conclusions: Based on these statistics, from 1999 to 2018, we observe a variable level of suicide rates. In the discussed years 1999–2018 over 95,000 people have successfully committed suicide in our country. Poland is currently in second place in Europe in terms of juvenile suicides and one of the European countries where the gender disparity (advantage of men over women) in terms of suicides is the highest.

AbstractNaturally occurring stable isotope ratios in animal tissues allow estimation of species trophic position and ecological niche. Measuring multiple isotopes of migratory species along flyway bottlenecks offers the opportunity to sample multiple populations and species whose tissues carry information at continental scales. We measured δ2H, δ18O, δ13C, δ15N in juvenile feathers of 21 bird species captured at a migratory bottleneck in the Italian Alps. We examined if trends in individual isotopes reflected known migratory strategies and whether dietary (δ13C–δ15N) and spatially-explicit breeding origin (δ2H–δ18O) niche breadth (NB) differed among long-distance trans-Saharan (TS), short-distance (IP) and irruptive (IR) intra-Palearctic migrants, and whether they correlated with reported populations long-term trends. In both TS and IP groups, species δ2H declined with capture date, indicating that northern populations reached the stopover site later in the season, following a Type-I migration strategy. Values of δ2H indicated that breeding range of TS migrants extended farther north than IP and IR migrants. The breeding season was longer for IP migrants whose δ13C and δ15N values declined and increased, respectively, with time of capture. Average species dietary NB did not differ among migratory groups, but TS migrants displayed wider breeding origin niches, suggesting that long-distant migration is linked to broader ecological niches. Isotope origin NB well reflected species geographic range extent, while dietary NB did not correlate with literature accounts of species’ diet. We found no relationship between species breeding NB and population trends in Europe, suggesting that conditions in the breeding grounds, as inferred by stable isotopes, are not the only determinant of species’ long-term persistence. We demonstrate that ringing activities and isotopic measurements of passerines migrating through a bottleneck represents a unique opportunity to investigate large-scale life-history phenomena relevant to conservation.