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Takayama, Shuichi, und Chi-Huey Wong. „Chemo-enzymatic Approach to Carbohydrate Recognition“. Current Organic Chemistry 1, Nr. 2 (Juli 1997): 109–26. http://dx.doi.org/10.2174/1385272801666220120211432.
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Abstract: Carbohydrates are widespread in biological systems and are often associated with many specific recognition and signaling processes that lead to important biological functions and diseases. Considerable efforts have been directed toward understanding and mimicking such recognition processes, and developing effective agents to control these events. The pace of discovery research in glycobiology and development of carbohydrate-based therapeutics, however, has been relatively slow compared to that of other classes of biomolecules due to the lack of appropriate strategies and methods available for carbohydrate related research. This review summarizes some of the most recent developments in the field of carbohydrate research, with particular emphasis on the work from our laboratories regarding the use of chemo-enzymatic strategies to study carbohydrate recognition. Highlights include the the chemo-enzymatic synthesis of complex carbohydrates and glycoproteins, the rational and combinatorial synthesis of carbohydrate mimetics as inhibitors of selectins and viral RNA, and design and synthesis of mechanism-based inhibitors of glycoprocessing enzymes.
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BeMiller, James N. „Carbohydrates and carbohydrate polymers“. Trends in Food Science & Technology 4, Nr. 9 (September 1993): 319. http://dx.doi.org/10.1016/0924-2244(93)90085-o.
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Chavelas, Eneas A., und Enrique García-Hernández. „Heat capacity changes in carbohydrates and protein–carbohydrate complexes“. Biochemical Journal 420, Nr. 2 (13.05.2009): 239–47. http://dx.doi.org/10.1042/bj20082171.
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Carbohydrates are crucial for living cells, playing myriads of functional roles that range from being structural or energy-storage devices to molecular labels that, through non-covalent interaction with proteins, impart exquisite selectivity in processes such as molecular trafficking and cellular recognition. The molecular bases that govern the recognition between carbohydrates and proteins have not been fully understood yet. In the present study, we have obtained a surface-area-based model for the formation heat capacity of protein–carbohydrate complexes, which includes separate terms for the contributions of the two molecular types. The carbohydrate model, which was calibrated using carbohydrate dissolution data, indicates that the heat capacity contribution of a given group surface depends on its position in the saccharide molecule, a picture that is consistent with previous experimental and theoretical studies showing that the high abundance of hydroxy groups in carbohydrates yields particular solvation properties. This model was used to estimate the carbohydrate's contribution in the formation of a protein–carbohydrate complex, which in turn was used to obtain the heat capacity change associated with the protein's binding site. The model is able to account for protein–carbohydrate complexes that cannot be explained using a previous model that only considered the overall contribution of polar and apolar groups, while allowing a more detailed dissection of the elementary contributions that give rise to the formation heat capacity effects of these adducts.
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Afandi, Frendy Ahmad. „Correlation between High Carbohydrate Foods with Glycemic Index“. JURNAL PANGAN 28, Nr. 2 (28.11.2019): 145–60. http://dx.doi.org/10.33964/jp.v28i2.422.
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High carbohydrate food has been perceived as a food with high glycemic index (GI). Meanwhile, the risks of diabetes are frequently associated with the GI carbohydrate based foods. Therefore, a comprehensive study based on the literature review regarding the relationship between high-carbohydrate food and the glycemic index needs to be conducted. High-carbohydrate foods can be grouped into the available carbohydrates type and non-available carbohydrates type. Food with available carbohydrates such as glucose, disaccharide, digestible oligosaccharides, and starch have positive correlation with the GI. The non-available forms of carbohydrates are hardly digested by the body, so they usually have low GI. The non-available carbohydrates foods are fructooligosaccharide (FOS) and galactooligosaccharide (GOS), raffinose, stachyose, and verbascose. High-carbohydrate foods can have low GI value due to complex carbohydrates or resistant starches. The type of carbohydrate can be turned into non-available due to chemical modification, processing, or interacting with other components. This information is necessary because recently, people have high awareness in choosing carbohydrate food. Not only the amount consumed, but also its carbohydrate content, types of carbohydrates, and how they are processed are important to be observed.
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Englyst, Klaus N., und Hans N. Englyst. „Carbohydrate bioavailability“. British Journal of Nutrition 94, Nr. 1 (Juli 2005): 1–11. http://dx.doi.org/10.1079/bjn20051457.
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There is consensus that carbohydrate foods, in the form of fruit, vegetables and whole-grain products, are beneficial to health. However, there are strong indications that highly processed, fibre-depleted, and consequently rapidly digestible, energy-dense carbohydrate food products can lead to over-consumption and obesity-related diseases. Greater attention needs to be given to carbohydrate bioavailability, which is determined by the chemical identity and physical form of food. The objective of the present concept article is to provide a rational basis for the nutritional characterisation of dietary carbohydrates. Based on the properties of carbohydrate foods identified to be of specific relevance to health, we propose a classification and measurement scheme that divides dietary carbohydrates into glycaemic carbohydrates (digested and absorbed in the small intestine) and non-glycaemic carbohydrates (enter the large intestine). The glycaemic carbohydrates are characterised by sugar type, and by the likely rate of digestion described by in vitro measurements for rapidly available glucose and slowly available glucose. The main type of non-glycaemic carbohydrates is the plant cell-wall NSP, which is a marker of the natural fibre-rich diet recognised as beneficial to health. Other non-glycaemic carbohydrates include resistant starch and the resistant short-chain carbohydrates (non-digestible oligosaccharides), which should be measured and researched in their own right. The proposed classification and measurement scheme is complementary to the dietary fibre and glycaemic index concepts in the promotion of healthy diets with low energy density required for combating obesity-related diseases.
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Afik, D., E. C. Vidal, C. Martinez del Rio und W. H. Karasov. „Dietary modulation of intestinal hydrolytic enzymes in yellow-rumped warblers“. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 269, Nr. 2 (01.08.1995): R413—R420. http://dx.doi.org/10.1152/ajpregu.1995.269.2.r413.
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Many birds exhibit seasonal switches in diet and thus alter the nutrients predominating their food intake. We tested for dietary modulation of small intestine (SI) enzymes in yellow-rumped warblers, a species for which such diet changes are well documented. Birds were fed three diets formulated from either fruit, insect, or seed. We predicted that SI carbohydrases and peptidases would be modulated in direct correlation with relative levels of dietary carbohydrate and protein, respectively. Aminopeptidase N activity was about twice as high in birds eating the highest protein content diet. In contrast, there was no significant dietary effect on any of the carbohydrase activities. There was a proximal-to-distal decrease in activities of all the carbohydrases but not aminopeptidase N. The carbohydrase levels of yellow-rumps are relatively low when compared with other species in the same family and most similar to lower levels found in primarily insectivorous birds rather than in primarily granivorous or nectarivorous species. Considering this and the fact that they do not exhibit dietary modulation of carbohydrase levels, we conclude that yellow-rumps are not highly adapted for handling dietary carbohydrates, especially starch, although they might still efficiently break down and absorb sucrose and maltose if retention time were sufficiently long.
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Tetala, K. Kishore R., Marcel Giesbers, Gerben M. Visser, Ernst J. R. Sudhölter und Teris A. van Beek. „Carbohydrate Microarray on Glass: A Tool for Carbohydrate-Lectin Interactions“. Natural Product Communications 2, Nr. 4 (April 2007): 1934578X0700200. http://dx.doi.org/10.1177/1934578x0700200408.
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A simple method to immobilize carbohydrates on a glass surface to obtain a carbohydrate microarray is described. The array was used to study carbohydrate-lectin interactions. The glass surface was modified with aldehyde terminated linker groups of various chain lengths. Coupling of carbohydrates with an amino terminated alkyl spacer to the aldehyde terminated glass followed by reductive amination resulted in carbohydrate microarrays. Fluorescently labeled (FI-TC) lectins (concanavalin A and Arachis hypogaea) were used to study specific carbohydrate-lectin interactions. contact angle, atomic force microscopy (AFM) and confocal laser fluorescence microscopy (CLFM) techniques were used in this study to monitor the modification of the glass and the successful selective binding of lectins to the carbohydrate microarray.
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Gergely, Szilveszter, und András Salgó. „Changes in Carbohydrate Content during Wheat Maturation—What is Measured by near Infrared Spectroscopy?“ Journal of Near Infrared Spectroscopy 13, Nr. 1 (Februar 2005): 9–17. http://dx.doi.org/10.1255/jnirs.452.
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The role of bread, pasta and related products produced from milled wheat seeds is important to the human diet, so monitoring changes of starch content in developing grain is essential. Immature wheat grains are also used as a functional food, particularly as a source of water-soluble carbohydrates. The amount and variation in content of different carbohydrates changes considerably during maturation and these changes were non-destructively monitored in developing grain using near infrared (NIR) spectroscopy. Characteristic changes in three carbohydrate absorption bands [1585–1595 nm (Carbohydrate I), 2270–2280 nm (Carbohydrate II) and 2325–2335 nm (Carbohydrate III)] were identified and it was concluded that the different dynamics of carbohydrates (starch accumulation as well as synthesis/decomposition of water-soluble carbohydrates) could be followed sensitively by monitoring these three different regions of NIR spectra. Carbohydrate I represents the effect of starch accumulation during maturation based on the vibrations of intermolecular hydrogen bonded O–H groups in polysaccharides. Carbohydrate II is the manifestation of O–H stretching and C–C stretching vibrations existing unengaged in water-soluble carbohydrates while Carbohydrate III describes the changes in C–H stretching and deformation band of poly- and mono-oligosaccharides. NIR spectroscopic techniques are shown to be effective in monitoring plant physiological processes and the spectra have hidden information for predicting the stage of growth in wheat seed.
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Xue, Lamei, Xiaofang Chen, Juan Sun, Mingcong Fan, Haifeng Qian, Yan Li und Li Wang. „Maternal Dietary Carbohydrate and Pregnancy Outcomes: Quality over Quantity“. Nutrients 16, Nr. 14 (14.07.2024): 2269. http://dx.doi.org/10.3390/nu16142269.
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Dietary nutrition plays a crucial role in determining pregnancy outcomes, with poor diet being a major contributor to pregnancy metabolic syndrome and metabolic disorders in offspring. While carbohydrates are essential for fetal development, the excessive consumption of low-quality carbohydrates can increase the risk of pregnancy complications and have lasting negative effects on offspring development. Recent studies not only highlighted the link between carbohydrate intake during pregnancy, maternal health, and offspring well-being, but also suggested that the quality of carbohydrate foods consumed is more critical. This article reviews the impacts of low-carbohydrate and high-carbohydrate diets on pregnancy complications and offspring health, introduces the varied physiological effects of different types of carbohydrate consumption during pregnancy, and emphasizes the importance of both the quantity and quality of carbohydrates in nutritional interventions during pregnancy. These findings may offer valuable insights for guiding dietary interventions during pregnancy and shaping the future development of carbohydrate-rich foods.
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Macdonald, Ian A. „Dietary strategies for the management of cardiovascular risk: role of dietary carbohydrates“. Proceedings of the Nutrition Society 73, Nr. 2 (21.02.2014): 167–71. http://dx.doi.org/10.1017/s0029665114000032.
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Carbohydrate-rich foods are an essential component of the diet, providing the glucose that is continuously required by the nervous system and some other cells and tissues in the body for normal function. There is some concern that too much carbohydrate or certain types of carbohydrate such as fructose or the high glycaemic index carbohydrate foods that produce large, rapid increases in blood glucose may be detrimental to health. This review considers these issues and also summarises the public health advice currently available in Europe and the USA concerning dietary carbohydrates. The UK Scientific Advisory Committee on Nutrition is currently reviewing carbohydrates and health, and the subsequent report should help clarify some of the concerns regarding carbohydrates and health.
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PAPOUTSOGLOU (Ε.Σ. ΠΑΠΟΥΤΣΟΓΛΟΥ), E. S., und A. R. LYNDON. „In vitro comparison of hydrolysis of different starches along the digestive tract of teleosts important for aquaculture“. Journal of the Hellenic Veterinary Medical Society 57, Nr. 3 (29.11.2017): 205. http://dx.doi.org/10.12681/jhvms.15040.
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The in vitro hydrolysis of different starches (potato, rice, wheat, corn, sorghum), as well as an intermediate product of malting process (brewer's spent grain), by blue tilapia, Oreochromis aureus, gilthead sea bream, Sparus aurata and European sea bass, Dicentrarchus labrax, were compared (total carbohydrase assay, 37° C, pH 7.6,4 hours incubation). Obtained results (significandy higher hydrolysis levels obtained for potato, rice and sorghum starch) suggest that starch source and associated properties (starch granule size, amylose content) and modifications applied may have significant difference on its digestion by fish digestive carbohydrases. Furthermore, the importance of brewer's spent grain as a low-cost carbohydrate source and feed component, in relation to aglucosidase adaptive response to dietary carbohydrate, is also considered significant.
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Mclaughlin, Steven P., und Ryan R. Williams. „Carbohidratos y Floración en Hesperaloë funifera (Koch) Trel. (Samandoque)“. Botanical Sciences, Nr. 66 (27.05.2017): 67. http://dx.doi.org/10.17129/botsci.1612.
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Several researchers have noted that flowering in Agavaceae requires substantial resources, but few studies have attempted to directly measure such resources. T his study addresses the hypothesis that fruit set in Hesperaloë funifera is limited by available carbohydrates. The accumulation of total non-structural carbohydrates (TNC) prior to flowering was measured, and total requirements for carbohydrate were estimated. Hesperaloë funifera was found to accumulate fructans, and roots were an important organ for storage of accumulated carbohydrates. Carbohydrates stored in the plant prior to flowering are sufficient to meet only about onethird of the carbohydrate needed to produce an average inflorescence with 1 % to 2% fruit set. All of the carbohydrate produced by photosynthesis from May through August is needed to support flowering and fruit production. Low percentage fruit set in Hesperaloë funifera is probably due to a deficiency of carbohydrate resources.
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Shang, Kun, Siyu Song, Yaping Cheng, Lili Guo, Yuxin Pei, Xiaomeng Lv, Teodor Aastrup und Zhichao Pei. „Fabrication of Carbohydrate Chips Based on Polydopamine for Real-Time Determination of Carbohydrate–Lectin Interactions by QCM Biosensor“. Polymers 10, Nr. 11 (16.11.2018): 1275. http://dx.doi.org/10.3390/polym10111275.
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A novel approach for preparing carbohydrate chips based on polydopamine (PDA) surface to study carbohydrate–lectin interactions by quartz crystal microbalance (QCM) biosensor instrument has been developed. The amino-carbohydrates were immobilized on PDA-coated quartz crystals via Schiff base reaction and/or Michael addition reaction. The resulting carbohydrate-chips were applied to QCM biosensor instrument with flow-through system for real-time detection of lectin–carbohydrate interactions. A series of plant lectins, including wheat germ agglutinin (WGA), concanavalin A (Con A), Ulex europaeus agglutinin I (UEA-I), soybean agglutinin (SBA), and peanut agglutinin (PNA), were evaluated for the binding to different kinds of carbohydrate chips. Clearly, the results show that the predicted lectin selectively binds to the carbohydrates, which demonstrates the applicability of the approach. Furthermore, the kinetics of the interactions between Con A and mannose, WGA and N-Acetylglucosamine were studied, respectively. This study provides an efficient approach to preparing carbohydrate chips based on PDA for the lectin–carbohydrate interactions study.
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Guldstrand, Marie C., und Caroline L. Simberg. „High-fat diets: healthy or unhealthy?“ Clinical Science 113, Nr. 10 (12.10.2007): 397–99. http://dx.doi.org/10.1042/cs20070263.
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In the current dietary recommendations for the treatment and prevention of Type 2 diabetes and its related complications, there is flexibility in the proportion of energy derived from monounsaturated fat and carbohydrate as a replacement for saturated fat. Over the last few years, several population studies have shown that subjects eating a lot of refined grains and processed foods have a much larger increase in waist circumference than those following a diet higher in monounsaturated fat, protein and carbohydrates rich in fibre and whole grain. In the present issue of Clinical Science, Sinitskaya and co-workers have demonstrated that, in normal-weight rodents categorized into groups of high-fat and medium-carbohydrate [53%/30% of energy as fat/carbohydrate; 19.66 kJ/g (4.7 kcal/g)], high-fat and low-carbohydrate [67%/9% of energy as fat/carbohydrate; 21.76 kJ/g (5.2 kcal/g)] and high-fat and carbohydrate-free [75%/0% of energy as fat/carbohydrate; 24.69 kJ/g (5.9 kcal/g)] diets, the high-fat diets containing carbohydrates were both obesogenic and diabetogenic, whereas the very-high-fat and carbohydrate-free diet was not obesogenic but led to insulin resistance and higher risk of cardiovascular disease. This finding may indicate that high-fat diets could easily give rise to an unhealthy diet when combined with carbohydrates, highlighting the significance of macronutrient composition, rather than caloric content, in high-fat diets.
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Scheibe, Christian, und Oliver Seitz. „PNA–sugar conjugates as tools for the spatial screening of carbohydrate–lectin interactions“. Pure and Applied Chemistry 84, Nr. 1 (08.12.2011): 77–85. http://dx.doi.org/10.1351/pac-con-11-08-07.
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Multivalent carbohydrate–lectin interactions are essential for a multitude of biological recognition events. Much effort has been spent in the synthesis of potent multivalent scaffolds in order to mimic or inhibit biological carbohydrate–protein interactions. However, the defined spatial presentation of carbohydrates remained a challenging task. Peptide nucleic acid (PNA)- and DNA-based double helices are useful scaffolds that enable the controlled display of carbohydrate ligands in a modular approach. The hybridization of PNA-sugar conjugates with complementary DNA strands provides multivalent complexes with defined spatial presentation of carbohydrates, which facilitates the spatial screening of carbohydrate–lectin interactions with Ångström-scale precision.
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Buddington, R. K., und J. W. Hilton. „Intestinal adaptations of rainbow trout to changes in dietary carbohydrate“. American Journal of Physiology-Gastrointestinal and Liver Physiology 253, Nr. 4 (01.10.1987): G489—G496. http://dx.doi.org/10.1152/ajpgi.1987.253.4.g489.
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Although omnivores are able to alter the structure and functions of their digestive system in response to changes in dietary carbohydrate content, it is unclear whether carnivores are capable of such adaptive flexibility. Hence we recorded growth rates, intestinal morphometrics and histology, and nutrient uptake rates and concentrations of disaccharidases in the intestines of a carnivorous fish, the rainbow trout, fed different levels and types of carbohydrate. The trout is unable to adaptively regulate digestive system structure and function to increase glucose availability in response to increasing levels of dietary carbohydrates, even to easily digestible forms such as glucose. Paradoxically, a reduction in the concentrations of enzymes associated with carbohydrate digestion in response to elevated levels of easily digested carbohydrates suggests that carnivores may actually try to repress carbohydrate digestion when glucose is available in high quantities. Thus the lower levels of carbohydrate in the diet of trout throughout their evolution has resulted in a reduced ability to phenotypically regulate the digestion of carbohydrates.
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Stenvall, N., M. Piisilä und P. Pulkkinen. „Seasonal fluctuation of root carbohydrates in hybrid aspen clones and its relationship to the sprouting efficiency of root cuttings“. Canadian Journal of Forest Research 39, Nr. 8 (August 2009): 1531–37. http://dx.doi.org/10.1139/x09-066.
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We examined the relationship between root carbohydrates and sprouting efficiency in four hybrid aspen ( Populus tremula × Populus tremuloides ) clones. Our hypothesis was that the interclonal variation in sprouting efficiency is due to the concentration of carbohydrates. In addition to that relationship, we wanted to study seasonal fluctuation of carbohydrates and how the –18 °C storage conditions of stock plants affects the stability of carbohydrate content and thus sprouting ability of roots cuttings. Clones varied in root carbohydrate content, and sucrose showed the greatest variation throughout the year. Sucrose levels were highest in the clone with the highest sprouting efficiency and lowest in the clone with the lowest sprouting efficiency. Carbohydrate concentrations were highest in winter and lowest in early autumn. In general, root cuttings sprouted most efficiently when root carbohydrate levels peaked. Although root cuttings taken from frozen (–18 °C) stock plants sprouted poorly in summer and autumn, they had high and almost constant carbohydrate concentrations throughout the year.
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.B.M, Dr Khalid. „ESTIMATION OF TOTAL CARBOHYDRATES CONTENT BY PHENOL SULPHURIC ACID METHOD IN ATIBALA [ABUTILON INDICUM SWEET“. Avishkara 01, Nr. 03 (2022): 03–06. http://dx.doi.org/10.56804/avishkara.2022.1302.
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Background: Atibala' means 'Ati' means very and 'Bala' means powerful, referring to the properties of this plant as very powerful Abutilon indicum (Linn.) is three meter in height. Traditionally, Root and bark are used as aphrodisiac, anti-diabetic, neuron tonic, and diuretic. It is proved that this plant contains rich amount of carbohydrates, proteins and amino acids, saponins, flavonoids, glycosides, phytosterols and phenolic compounds. Objective: The objective of the present study was to determine the total carbohydrate content in Atibala (Abutilon indicum) Materials & Methods: The total Carbohydrate content was estimated spectrophotometric ally by Phenol Sulphuric acid method. Results: The results showed that root of Atibala (Abutilon indicum) are rich source of Carbohydrates. The root extract of Atibala showed highest Carbohydrate content (34.95%). Conclusion: Atibala shown that the carbohydrate content is 34.95% for performing bodily function carbohydrate is essential sources for living organism, low carbohydrates intake results to muscle breakdown. This was the rapid spectrophotometric method by Phenol sulphuric acid. Keywords: Atibala (Abutilon indicum), Carbohydrates, Phenol sulphuric Acid Method. Study and Article History: Sample Received at 06/07/2022 study conducted in ACRL, Revised on 22/07/2022 & published in Avishkara Vol 1, Issue 3, Aug 2022.
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Hastuti, Puji hastuti Puji. „Hubungan Pola Konsumsi Karbohidrat Sederhana dan Karbohidrat Kompleks Dengan Kadar HbA1c Pada Penderita Diabetes Mellitus Tipe 2 Di Wilayah Kerja Puskesmas Kedawung 1 Kabupaten Sragen“. Jurnal Gizi dan Pangan Soedirman 4, Nr. 1 (12.05.2020): 40. http://dx.doi.org/10.20884/1.jgps.2020.4.1.1660.
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Background : Prevalence of Type 2 Diabetes Mellitus (DM) is epidemiologically increasing worldwide. Simple carbohidrate consumption patterns and complex carbohydrates consumption patterns are the risk factors of Type 2 DM, which can increase blood glucose levels so that it will affect DM Type 2 control through HbA1c examination. This study aimed to determine the relationship between simple carbohydrate consumption pattern and complex carbohydrates with HbA1c levels . Methods : This was an observational research using cross sectional design with 40 subject, sample was selected by total sampling which conduct in April until June 2019 at Puskesmas Kedawung 1 area. This research used FFQ questionnaire as research instrument. HbA1c levels examined using spectrophotometer. Chi square was used as statistic analysis. Results : The statistical test results suggested that there was correlation between simple carbohydrate consumption patterns and HbA1c levels (p=0,000) and also there was correlation between complex carbohydrate consumption patterns and HbA1c levels . Conclusion : There was correlation between pattern simple carbohydrate consumption and complex carbohydrate consumption with HbA1c levels. Keywords : Diabetes Mellitus, Pattern consumption , carbohydrates , HbA1c levels
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Johnson, M. A., und B. M. Pinto. „Molecular Mimicry of Carbohydrates by Peptides“. Australian Journal of Chemistry 55, Nr. 2 (2002): 13. http://dx.doi.org/10.1071/ch02047.
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The use of carbohydrates as drugs and vaccines has several limitations. Molecular mimics of carbohydrates provide an alternative source of compounds to target pathways involving protein-carbohydrate interactions. In recent years, immunological studies have demonstrated the ability of certain peptides to act as molecular mimics of carbohydrates, in that they are able to induce an anti-carbohydrate immune response. Carbohydrate-mimetic peptides that bind to enzymes and lectins have also been discovered. The nature of this mimicry at the molecular level is currently the subject of investigation. Structural data regarding the origin of mimicry are reviewed, and their implications for drug and vaccine design are presented.
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Sievenpiper, John L. „Low-carbohydrate diets and cardiometabolic health: the importance of carbohydrate quality over quantity“. Nutrition Reviews 78, Supplement_1 (30.07.2020): 69–77. http://dx.doi.org/10.1093/nutrit/nuz082.
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Abstract Carbohydrates are increasingly being implicated in the epidemics of obesity, diabetes, and their downstream cardiometabolic diseases. The “carbohydrate-insulin model” has been proposed to explain this role of carbohydrates. It posits that a high intake of carbohydrate induces endocrine deregulation marked by hyperinsulinemia, leading to energy partitioning with increased storage of energy in adipose tissue resulting in adaptive increases in food intake and decreases in energy expenditure. Whether all carbohydrate foods under real-world feeding conditions directly contribute to weight gain and its complications or whether this model can explain these clinical phenomena requires close inspection. The aim of this review is to assess the evidence for the role of carbohydrate quantity vs quality in cardiometabolic health. Although the clinical investigations of the “carbohydrate-insulin model” have shown the requisite decreases in insulin secretion and increases in fat oxidation, there has been a failure to achieve the expected fat loss under low-carbohydrate feeding. Systematic reviews with pairwise and network meta-analyses of the best available evidence have failed to show the superiority of low-carbohydrate diets on long-term clinical weight loss outcomes or that all sources of carbohydrate behave equally. High-carbohydrate diets that emphasize foods containing important nutrients and substances, including high-quality carbohydrate such as whole grains (especially oats and barley), pulses, or fruit; low glycemic index and load; or high fiber (especially viscous fiber sources) decrease intermediate cardiometabolic risk factors in randomized trials and are associated with weight loss and decreased incidence of diabetes, cardiovascular disease, and cardiovascular mortality in prospective cohort studies. The evidence for sugars as a marker of carbohydrate quality appears to be highly dependent on energy control (comparator) and food source (matrix), with sugar-sweetened beverages providing excess energy showing evidence of harm, and with high-quality carbohydrate food sources containing sugars such as fruit, 100% fruit juice, yogurt, and breakfast cereals showing evidence of benefit in energy-matched substitutions for refined starches (low-quality carbohydrate food sources). These data reflect the current shift in dietary guidance that allows for flexibility in the proportion of macronutrients (including carbohydrates) in the diet, with a focus on quality over quantity and dietary patterns over single nutrients.
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Ilhami, B. T. K., A. S. Abidin, N. W. R. Martyasari, N. S. H. Kurniawan, H. Padmi, A. L. Sunarwidhi, S. Widyastuti, H. Sunarpi und E. S. Prasedya. „Measurement of macroalgae total carbohydrate content found in Lendang Luar coast, Lombok, Indonesia for potential sources of bioethanol“. IOP Conference Series: Earth and Environmental Science 913, Nr. 1 (01.11.2021): 012077. http://dx.doi.org/10.1088/1755-1315/913/1/012077.
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Abstract Bioethanol is a renewable alternative energy through the process of fermenting sugar from carbohydrate sources by adding microorganisms such as yeast or bacteria. Macroalgae or known as seaweed is one of the producers in the marine environment which has a high carbohydrate content so that it can be used as raw material for bioethanol. Macroalgae contains specific carbohydrates including laminarin, mannitol, alginate, agar and polysaccharides. The high carbohydrate content indicates the ethanol content produced. The aim of the study was to initial screen total carbohydrates in red algae (G. latifolium and G rugosa) and brown algae (M rosea, S. crassifolium, S. cristaefolium, S. polycystum, P.australis and T. muray ana). Carbohydrate total analysis was performed by colorimetric assay using the BioVision kit. The overall carbohydrate content found in macroalgae samples in this study was 28.23 fig (DW)1. The highest carbohydrate content was obtained by G. latifolium (37.50 fig (DW)1), followed by G rugosa (34.27 fig (DW)1) and S. cristaefolium (33.33 fig (DW)1). Current results show that macroalgae exhibits sufficient amounts of carbohydrate which could potentially be further developed as source for biotehanol.
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Aljohani, Salwa, Waleed M. Hussein, Istvan Toth und Pavla Simerska. „Carbohydrates in Vaccine Development“. Current Drug Delivery 16, Nr. 7 (03.10.2019): 609–17. http://dx.doi.org/10.2174/1567201816666190702153612.
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Despite advances in the development of new vaccines, there are still some diseases with no vaccine solutions. Therefore, further efforts are required to more comprehensively discern the different antigenic components of these microorganisms on a molecular level. This review summarizes advancement in the development of new carbohydrate-based vaccines. Following traditional vaccine counterparts, the carbohydrate-based vaccines introduced a new approach in fighting infectious diseases. Carbohydrates have played various roles in the development of carbohydrate-based vaccines, which are described in this review, including carbohydrates acting as antigens, carriers or targeting moieties. Carbohydrate-based vaccines against infectious diseases, such as group A streptococcus, meningococcal meningitis and human immunodeficiency virus, are also discussed. A number of carbohydrate- based vaccines, such as Pneumovax 23, Menveo and Pentacel, have been successfully marketed in the past few years and there is a promising standpoint for many more to come in the near future.
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Garcia-Luis, A., F. Fornes und J. L. Guardiola. „Leaf Carbohydrates and Flower Formation in Citrus“. Journal of the American Society for Horticultural Science 120, Nr. 2 (März 1995): 222–27. http://dx.doi.org/10.21273/jashs.120.2.222.
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The carbohydrate contents of the leaves of satsuma mandarin (Citrus unshiu Marc.) trees were altered before or during the low temperature flower induction period to determine the relationship between gross levels of carbohydrates and flower formation. Early removal of the fruit and girdling of the branches on either fruiting or defruited trees caused an accumulation of carbohydrates in the leaves and increased flower formation. Shading the trees resulted in a transient reduction in leaf carbohydrate levels and in a decrease in flower formation. Although a relationship between carbohydrate levels and flowering was consistently found, our results show that the gross levels of carbohydrates do not appear to limit flower formation in citrus.
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Hatata, Mohammad, und Michel Farah. „Specific effects of certain salts on carbohydrate metabolism in young corn seedlings“. Acta Societatis Botanicorum Poloniae 51, Nr. 1 (2014): 81–90. http://dx.doi.org/10.5586/asbp.1982.008.
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The effects of sodium and magnesium chlorides and sulphates on carbohydrate metabolism of corn seedlings and their component parts were studied. There was a decrease in the total carbohydrate content of seedlings with advance of time, in control and in different concentrations of salts. The decrease became less marked with increase of salt concentrations. The main effect of salinization, on the changes in carbohydrates, was strongest on the roots and grains. The roots contained the lowest proportion of the various carbohydrate fractions. This feature suggests that the mobilization of carbohydrates from grains to roots is greatly retarded by salinization. Both cations and anions exert an influence on the conversion of reserve carbohydrates.
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Xavier, Nuno M., und Amélia P. Rauter. „Environmentally friendly approaches to the synthesis of new antibiotics from sugars“. Pure and Applied Chemistry 84, Nr. 3 (15.02.2012): 803–16. http://dx.doi.org/10.1351/pac-con-11-11-11.
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In light of the biological importance of carbohydrates and their role when present in antibiotic agents, the design and synthesis of carbohydrate-based antibiotics has occupied a prominent place in drug discovery. This review focuses on synthetic carbohydrate antimicrobial agents, giving special emphasis to novel structures easily accessible from readily available carbohydrate precursors.
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Mobassaleh, Munir, Robert K. Montgomery, Jeffrey A. Biller und Richard J. Grand. „Development of Carbohydrate Absorption in the Fetus and Neonate“. Pediatrics 75, Nr. 1 (01.01.1985): 160–66. http://dx.doi.org/10.1542/peds.75.1.160.
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Maturation of mechanisms for carbohydrate absorption occurs in a defined sequence during human fetal development. The intestinal enzymes, lactase, sucrase, maltase, isomaltase, and glucoamylase, are at mature levels in the term fetus. Mature levels of pancreatic amylase activity and glucose transport occur postnatally, and levels are low in both the term and preterm neonate. In the preterm infant, sucrase, maltase, and isomaltase are usually fully active, but lactase activity, which increases markedly from 24 to 40 weeks, may be low depending upon fetal age. Despite these developmental patterns, clinical lactose intolerance is uncommon. Postnatal adaptive responses to ingested carbohydrates lead to competent carbohydrate absorption. Inadequately absorbed carbohydrates are salvaged by colonic flora through fermentation of carbohydrates to hydrogen gas and short-chain fatty acids; the latter are readily absorbed by the colon. In this setting, carbohydrate tends to be absent from the stool. Noninvasive reflection of the status of carbohydrate absorption may be obtained from breath hydrogen testing, a technique of particular value in young infants.
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Shin, Injae, Jin Cho und Doo Boo. „Carbohydrate Arrays for Functional Studies of Carbohydrates“. Combinatorial Chemistry & High Throughput Screening 7, Nr. 6 (01.09.2004): 565–74. http://dx.doi.org/10.2174/1386207043328472.
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Buchholz, K. „Introduction: The spirit of carbohydrates – carbohydrate bioengineering“. Biocatalysis and Biotransformation 26, Nr. 1-2 (Januar 2008): 3–11. http://dx.doi.org/10.1080/10242420701806751.
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Khodzhaeva, M. A., Ya V. Rashkes, E. S. Kondratenko und D. A. Rakhimov. „Carbohydrates ofAllium. IX. Carbohydrate components ofAllium cepa“. Chemistry of Natural Compounds 21, Nr. 2 (1985): 162–65. http://dx.doi.org/10.1007/bf00714902.
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NICOTRA, F. „ChemInform Abstract: Modified Carbohydrates and Carbohydrate Analogues“. ChemInform 29, Nr. 22 (22.06.2010): no. http://dx.doi.org/10.1002/chin.199822245.
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Stephenson, RA, TS Rasmussen und EC Gallagher. „Timing of nitrogen application to macadamias. 2. Storage carbohydrates“. Australian Journal of Experimental Agriculture 29, Nr. 4 (1989): 575. http://dx.doi.org/10.1071/ea9890575.
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Samples of wood and bark were taken monthly from macadamia (Macadamia integrifolia Maiden and Betche) tree trunks and analysed for total 'fermentable' carbohydrates. Carbohydrates (%, w/w) were high during autumn-winter and declined to low levels in summer when oil was accumulating in kernels. Reproductive growth appeared to draw heavily on carbohydrate reserves. Vegetative growth, on the other hand, was not generally reflected in lower carbohydrate levels in tree trunks. Application of nitrogen (N) during summer resulted in higher carbohydrate levels than when applied in autumn or winter. Despite these differences, there was no apparent accumulation of carbohydrates in the months directly following application of N. The low N status of control trees was not reflected in low concentrations of storage carbohydrates. Wood tissues had a higher concentration of carbohydrates than bark, perhaps reflecting the sampling procedures used. Further work to quantify the contribution of storage carbohydrates and current photosynthesis to yield is justified.
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Miller, William B., und Robert W. Langhans. „Carbohydrate Changes of Easter Lilies during Growth in Normal and Reduced Irradiance Environments“. Journal of the American Society for Horticultural Science 114, Nr. 2 (März 1989): 310–15. http://dx.doi.org/10.21273/jashs.114.2.310.
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Abstract Changes in carbohydrate types and quantities in the bulbs, stems, leaves, and buds of Easter lilies (Lilium longiflorum Thunb. ‘Nellie White’) forced under ambient or reduced irradiance conditions were investigated. Analysis by high-performance liquid chromatography (HPLC) revealed that sucrose is the dominant soluble carbohydrate in bulb tissues, with glucose, fructose, and mannose present at significantly lower concentrations. During growth of the flowering shoot, mother bulb reserves are preferentially used regardless of greenhouse irradiance. Beginning 40 days after planting, there was a steady decrease in mother bulb starch concentration until anthesis, 70 days later. Increased bulb sucrose, glucose, mannose, and fructose concentrations were correlated with the induction of starch breakdown and carbohydrate export. Under natural greenhouse irradiance conditions, daughter bulb carbohydrate reserves were not used, as starch and soluble carbohydrate concentrations remained constant. Irradiance reductions of 50% to 85% significantly reduced total carbohydrate concentration in leaves and floral buds and induced export from the daughter bulb, as evidenced by elevated levels of daughter bulb soluble carbohydrates and reductions in starch concentration. Dark-grown plants exhibited similar daughter bulb carbohydrate metabolism patterns as plants grown in full sun: starch was not hydrolyzed and soluble carbohydrates did not increase in concentration. Collectively, these results suggest 1) bulb export metabolism is characterized by elevated soluble carbohydrate concentrations, 2) there is a minimum irradiance requirement for carbohydrate export processes from the daughter bulb, and 3) reductions in greenhouse irradiance result in reduced carbohydrate levels in Easter lily leaves and flower buds.
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Lojkova, Lea, Valerie Vranová, Pavel Formánek, Ida Drápelová, Martin Brtnicky und Rahul Datta. „Enantiomers of Carbohydrates and Their Role in Ecosystem Interactions: A Review“. Symmetry 12, Nr. 3 (17.03.2020): 470. http://dx.doi.org/10.3390/sym12030470.
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D- and most L-enantiomers of carbohydrates and carbohydrate-containing compounds occur naturally in plants and other organisms. These enantiomers play many important roles in plants including building up biomass, defense against pathogens, herbivory, abiotic stress, and plant nutrition. Carbohydrate enantiomers are also precursors of many plant compounds that significantly contribute to plant aroma. Microorganisms, insects, and other animals utilize both types of carbohydrate enantiomers, but their biomass and excrements are dominated by D-enantiomers. The aim of this work was to review the current knowledge about carbohydrate enantiomers in ecosystems with respect to both their metabolism in plants and occurrence in soils, and to identify critical knowledge gaps and directions for future research. Knowledge about the significance of D- versus L-enantiomers of carbohydrates in soils is rare. Determining the mechanism of genetic regulation of D- and L-carbohydrate metabolism in plants with respect to pathogen and pest control and ecosystem interactions represent the knowledge gaps and a direction for future research.
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PAPOUTSOGLOU, E. S., und A. R. LYNDON. „Digestive proteases and carbohydrases along the alimentary tract of the stargazer, Uranoscopus scaber Linnaeus, 1753“. Mediterranean Marine Science 7, Nr. 1 (01.06.2006): 5. http://dx.doi.org/10.12681/mms.173.
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Digestive enzyme activity and capacity (activity x tissue weight) for protein (total protease assay, 25° C) and carbohydrates (total carbohydrase and alpha-glucosidase assay at 5, 18 and 25° C) was investigated for the carnivorous stargazer, Uranoscopus scaber along its digestive tract. Results indicated that whole gut total protease activity was highest at pH 1.5 (P<0.05) (25° C) in U. scaber, (6.64±2.55 mg tyrosine per g digestive tract per minute, pH 1.5). Total protease activity was apparent mainly in the stomach at pH 1.5 (9.73±3.3), and to a lesser degree in the anterior intestine (11.15±1.5, pH 10.0) and pyloric caeca (4.92±2.06, pH 10.0), especially at pH 9.0 and 10.0. Furthermore, 60% of total capacity for protein digestion derives from the stomach region, which takes up 65% of the digestive tract. Total carbohydrase activity and capacity levels were very low compared to other carnivorous teleosts, indicating very low tendency for complex, large molecular weight carbohydrate digestion. However, alpha-glucosidase levels were higher, a fact which combined with relevant data for other marine carnivorous teleosts suggests a possible role of disaccharide in relation to marine carnivorous fish dietary carbohydrate inclusion.
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Tondt, Justin, William S. Yancy und Eric C. Westman. „Application of nutrient essentiality criteria to dietary carbohydrates“. Nutrition Research Reviews 33, Nr. 2 (27.02.2020): 260–70. http://dx.doi.org/10.1017/s0954422420000050.
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AbstractThe purpose of the present review is to describe how human physiology at very low carbohydrate intakes relates to the criteria for nutritional essentiality. Although we did not limit ourselves to one particular type or function of carbohydrates, we did primarily focus on glucose utilisation as that function was used to determine the recommended daily allowance. In the general population, the human body is able to endogenously synthesise carbohydrates, and does not show signs of deficiency in the absence of dietary carbohydrates. However, in certain genetic defects, such as glycogen storage disease type I, absence of dietary carbohydrates causes abnormalities that are resolved with dietary supplementation of carbohydrates. Therefore, dietary carbohydrates may be defined as conditionally essential nutrients because they are nutrients that are not required in the diet for the general population but are required for specific subpopulations. Ketosis may be considered a physiological normal state due to its occurrence in infants in addition to at very low carbohydrate intakes. Although sources of dietary carbohydrates can provide beneficial micronutrients, no signs of micronutrient deficiencies have been reported in clinical trials of low-carbohydrate ketogenic diets. Nonetheless, more research is needed on how micronutrient requirements can change depending on the dietary and metabolic context. More research is also needed on the role of dietary fibre during a low-carbohydrate ketogenic diet as the beneficial effects of dietary fibre were determined on a standard diet and several studies have shown beneficial effects of decreasing non-digestible carbohydrates.
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Ohlin, Mats, Laura von Schantz, Tobias E. Schrader, Andreas Ostermann, Derek T. Logan und S. Zoë Fisher. „Crystallization, neutron data collection, initial structure refinement and analysis of a xyloglucan heptamer bound to an engineered carbohydrate-binding module from xylanase“. Acta Crystallographica Section F Structural Biology Communications 71, Nr. 8 (29.07.2015): 1072–77. http://dx.doi.org/10.1107/s2053230x15011383.
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Carbohydrate-binding modules (CBMs) are discrete parts of carbohydrate-hydrolyzing enzymes that bind specific types of carbohydrates. Ultra high-resolution X-ray crystallographic studies of CBMs have helped to decipher the basis for specificity in carbohydrate–protein interactions. However, additional studies are needed to better understand which structural determinants confer which carbohydrate-binding properties. To address these issues, neutron crystallographic studies were initiated on one experimentally engineered CBM derived from a xylanase, X-2 L110F, a protein that is able to bind several different plant carbohydrates such as xylan, β-glucan and xyloglucan. This protein evolved from a CBM present in xylanase Xyn10A ofRhodothermus marinus. The protein was complexed with a branched xyloglucan heptasaccharide. Large single crystals of hydrogenous protein (∼1.6 mm3) were grown at room temperature and subjected to H/D exchange. Both neutron and X-ray diffraction data sets were collected to 1.6 Å resolution. Joint neutron and X-ray refinement usingphenix.refineshowed significant density for residues involved in carbohydrate binding and revealed the details of a hydrogen-bonded water network around the binding site. This is the first report of a neutron structure of a CBM and will add to the understanding of protein–carbohydrate binding interactions.
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Birrenkott, Brian A., Cynthia A. Henson und Elden J. Stang. „Carbohydrate Levels and the Development of Fruit in Cranberry“. Journal of the American Society for Horticultural Science 116, Nr. 2 (März 1991): 174–78. http://dx.doi.org/10.21273/jashs.116.2.174.
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Cranberry (Vaccinium macrocarpon Ait. cv. Searles) vegetative tissue was analyzed at various stages of development to determine carbohydrate levels under field and greenhouse conditions and to identify the carbohydrates. Except during dormancy, cranberry uprights in the field had the highest concentration of carbohydrates (soluble and starch) at early blossom, when the lower flowers were at anthesis. As early flowers developed into fruit and upper flowers were at or just beyond anthesis, uprights had lower carbohydrate concentrations. As fruit growth slowed, soluble carbohydrate levels increased and were highest at dormancy. Upright shoot tissue produced the previous year and trailing woody stems followed the same trend as the current season's growth but had consistently lower soluble carbohydrate levels at each growth stage. Starch levels were low in current growth and did not change appreciably with fruit development. Starch was primarily stored and subsequently depleted in the previous season's upright growth and trailing woody stems. Tissue from the greenhouse was generally higher in carbohydrates than was field-grown tissue. Fruit developed from 53% of the flowers under greenhouse conditions, compared to 38% in the field. Insufficient carbohydrate levels may be responsible for the low fruit set observed in the field. Sucrose, glucose, fructose, raffinose, and stachyose were present in cranberry vegetative tissue.
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Satoh, Yuhi, Shigeki Wada und Shun’ichi Hisamatsu. „Relationship between iodine and carbohydrate contents in the seagrass Zostera marina on the northwestern Pacific coast of central Japan“. Botanica Marina 63, Nr. 3 (25.06.2020): 273–81. http://dx.doi.org/10.1515/bot-2020-0004.
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AbstractPreviously, we reported seasonal variation in iodine contents in the seagrass Zostera marina. Herein, we sought the factors controlling this variation, and investigated relationships between iodine and carbohydrate contents, using extracts and residues of seagrass samples extracted with 0.1 N HCl. In plants, carbohydrates in HCl-extracted and residual fractions are considered to represent storage and structural carbohydrates, respectively. On average, 44% and 56% of total iodine in samples was contained in the HCl-extracted and residual fractions, respectively. Both HCl-extracted and residual iodine contents showed seasonal trends similar to that of total iodine, being high in winter–spring and low in summer. Total and HCl-extracted carbohydrate contents showed reverse seasonal trends from those of iodine, whereas residual carbohydrate contents had comparable values throughout the sampling period. In the total and HCl-extracted fractions, negative correlations between iodine and carbohydrate contents were confirmed, suggesting that carbohydrates do not play important roles in iodine accumulation. Although most monosaccharide contents were not correlated with iodine contents in these two fractions, residual galactose content was positively correlated with residual iodine. We accordingly suggest that one or more specific structural carbohydrate constituents may potentially function as an iodine store in Z. marina.
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Wu, Caiying, Mengxi Zhang, Shuyi Zhou und Xiaolei, Zhong. „The Role of A High-Carbohydrates Diet on Alzheimers Disease“. Theoretical and Natural Science 4, Nr. 1 (28.04.2023): 46–55. http://dx.doi.org/10.54254/2753-8818/4/20220510.
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Brain diseases, like majority illnesses, are influenced in some way by nutrition. Alzheimers disease, which is characterized by brain cell deaths and memory loss, is significantly influenced by sugar intake. The frequency, quantity, and type of carbohydrates can influence AD development and outcomes. Whether highly processed or not, carbohydrate-rich foods influence AD. This paper discusses how a high-carbohydrate diet increases the chances of AD development and aggravation. General introduction to carbohydrate diets and the etiology of AD are explained. Subsequently, details on nonmodified and modified AD risk factors are addressed. The present paper moreover examines the imperative relationship between AD and high-carbohydrates diets. Particularly, the paper elucidates how: carbohydrate-rich diets impair cognitive function; how the diet aggravates AD ramifications. Furthermore, the paper evaluates how high-carbohydrates diets: alter AD biomarkers; interact with age to influence AD; and how carbohydrate-rich diets prevent brain cell growth and repair. The report addresses the prevailing therapeutic methods that can be employed to prevent and manage Alzheimers disease. Such interventions include the use of caffeine to significantly less cognitive deterioration in AD patients is addressed. Other interventions addressed regard how ketogenic diets can effectively aid with AD prevention; minimal sugar consumption; and how physical activities can aid AD prevention and management. Besides, AD-derived diseases are also addressed. The paper finds that high-carbohydrate diets should be avoided, and healthier lifestyle practices are integral for AD prevention and management.
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Orlova, N. D., und D. A. Egorova. „Research of carbohydrate type influence on Lonicera caerulea l. Morphogenetic potential in vitro“. Pomiculture and small fruits culture in Russia 61 (03.08.2020): 54–60. http://dx.doi.org/10.31676/2073-4948-2020-61-54-60.
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The clonal micropropagation technique of valuable Lonicera caerulea L. varieties (Indigo Gem, Moskovskaya 23, Diana, Jugana) has been improved. The effect of various types and concentrations of carbohydrates on microshoots regeneration of the genus Lonicera L. representatives was studied. It is shown that the concentration of carbohydrates has the greatest effect on microshoots height and the type of carbohydrate nutrition has the greatest effect on multiplication factor. The type of carbohydrate nutrition (42 %) had the greatest influence on multiplication factor. Peculiarities of varieties, genetic characteristics interaction, carbohydrate nutrition type and concentration had a lesser effect (20 %, 14 % and 11 % respectively). The variety Moskovskaya 23 was characterized by the highest microshoots number (49.6 mm). The highest multiplication factor in the studied varieties, regardless of the type of carbohydrate nutrition, was observed at concentration of 40 g/l (11.57).
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Scott, Sam, Patrick Kempf, Lia Bally und Christoph Stettler. „Carbohydrate Intake in the Context of Exercise in People with Type 1 Diabetes“. Nutrients 11, Nr. 12 (10.12.2019): 3017. http://dx.doi.org/10.3390/nu11123017.
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Although the benefits of regular exercise on cardiovascular risk factors are well established for people with type 1 diabetes (T1D), glycemic control remains a challenge during exercise. Carbohydrate consumption to fuel the exercise bout and/or for hypoglycemia prevention is an important cornerstone to maintain performance and avoid hypoglycemia. The main strategies pertinent to carbohydrate supplementation in the context of exercise cover three aspects: the amount of carbohydrates ingested (i.e., quantity in relation to demands to fuel exercise and avoid hypoglycemia), the timing of the intake (before, during and after the exercise, as well as circadian factors), and the quality of the carbohydrates (encompassing differing carbohydrate types, as well as the context within a meal and the associated macronutrients). The aim of this review is to comprehensively summarize the literature on carbohydrate intake in the context of exercise in people with T1D.
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Piotrowicz-Cieślak, Agnieszka I., Pedro Macedonio Gracia-Lopez und Krzysztof Gulewicz. „Cyclitols, galactosyl cyclitols and raffinose family oligosaccharides in Mexican wild lupin seeds“. Acta Societatis Botanicorum Poloniae 72, Nr. 2 (2011): 109–14. http://dx.doi.org/10.5586/asbp.2003.014.
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Ten to 16 ethanol-soluble carbohydrate components were identified in the seeds of six Mexican wild lupins. The analysed carbohydrates included: monosaccharides, disaccharides, cyclitols, galactosyl cyclitols and raffinose family oligosaccharides. Stachyose and sucrose were the main carbohydrate component in the <em>Lupinus montanus</em>, <em>L. rotundiflorus</em>, <em>L. exaltatus</em>, <em>L. mexicanus </em>and <em>L. elegans</em> seeds. Only trace quantities of verbascose were detected in <em>Lupinus mexicanus </em>seeds. The analysed seeds accumulated 38 to 78 mg/g d.m. carbohydrates. The raffinose family oligosaccharides constituted 41 to 85.2% of the identified carbohydrate component pool. The analysed <em>Lupinus </em>seeds contained 3 to 8 unidentified carbohydrate components.
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Bashiri, Sahra, Prashamsa Koirala, Istvan Toth und Mariusz Skwarczynski. „Carbohydrate Immune Adjuvants in Subunit Vaccines“. Pharmaceutics 12, Nr. 10 (14.10.2020): 965. http://dx.doi.org/10.3390/pharmaceutics12100965.
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Modern subunit vaccines are composed of antigens and a delivery system and/or adjuvant (immune stimulator) that triggers the desired immune responses. Adjuvants mimic pathogen-associated molecular patterns (PAMPs) that are typically associated with infections. Carbohydrates displayed on the surface of pathogens are often recognized as PAMPs by receptors on antigen-presenting cells (APCs). Consequently, carbohydrates and their analogues have been used as adjuvants and delivery systems to promote antigen transport to APCs. Carbohydrates are biocompatible, usually nontoxic, biodegradable, and some are mucoadhesive. As such, carbohydrates and their derivatives have been intensively explored for the development of new adjuvants. This review assesses the immunological functions of carbohydrate ligands and their ability to enhance systemic and mucosal immune responses against co-administered antigens. The role of carbohydrate-based adjuvants/delivery systems in the development of subunit vaccines is discussed in detail.
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Di, Xiangjie, Xiao Liang, Chao Shen, Yuwen Pei, Bin Wu und Zhiyao He. „Carbohydrates Used in Polymeric Systems for Drug Delivery: From Structures to Applications“. Pharmaceutics 14, Nr. 4 (29.03.2022): 739. http://dx.doi.org/10.3390/pharmaceutics14040739.
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Carbohydrates, one of the most important compounds in living organisms, perform numerous roles, including those associated with the extracellular matrix, energy-related compounds, and information. Of these, polymeric carbohydrates are a class of substance with a long history in drug delivery that have attracted more attention in recent years. Because polymeric carbohydrates have the advantages of nontoxicity, biocompatibility, and biodegradability, they can be used in drug targeting, sustained drug release, immune antigens and adjuvants. In this review, various carbohydrate-based or carbohydrate-modified drug delivery systems and their applications in disease therapy have been surveyed. Specifically, this review focuses on the fundamental understanding of carbohydrate-based drug delivery systems, strategies for application, and the evaluation of biological activity. Future perspectives, including opportunities and challenges in this field, are also discussed.
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Turroni, Francesca, Francesco Strati, Elena Foroni, Fausta Serafini, Sabrina Duranti, Douwe van Sinderen und Marco Ventura. „Analysis of Predicted Carbohydrate Transport Systems Encoded by Bifidobacterium bifidum PRL2010“. Applied and Environmental Microbiology 78, Nr. 14 (04.05.2012): 5002–12. http://dx.doi.org/10.1128/aem.00629-12.
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ABSTRACTTheBifidobacterium bifidumPRL2010 genome encodes a relatively small set of predicted carbohydrate transporters. Growth experiments and transcriptome analyses ofB. bifidumPRL2010 revealed that carbohydrate utilization in this microorganism appears to be restricted to a relatively low number of carbohydrates.
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Liu, Hongyu, Ling Pan, Jianfei Shen, Beiping Tan, Xiaohui Dong, Qihui Yang, Shuyan Chi und Shuang Zhang. „Effects of Carbohydrase Supplementation on Growth Performance, Intestinal Digestive Enzymes and Flora, Glucose Metabolism Enzymes, and glut2 Gene Expression of Hybrid Grouper (Epinephelus fuscoguttatus♀ × E. lanceolatus♂) Fed Different CHO/L Ratio Diets“. Metabolites 13, Nr. 1 (07.01.2023): 98. http://dx.doi.org/10.3390/metabo13010098.
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An optimal carbohydrate-to-lipid (CHO: L) ratio facilitates fish growth and protein conservation, and carbohydrase promotes nutrient absorption. Therefore, an 8-week feeding trial was conducted to investigate the effects of carbohydrase supplementation on growth performance, intestinal digestive enzymes and flora, glucose metabolism enzymes and glut2 gene expression in juvenile hybrid grouper (Epinephelus fuscoguttatus♀× Epinephelus lanceolatus♂) fed different CHO: L ratios diets. L, M, and H represent CHO:L ratios of 0.91, 1.92 and 3.91, respectively. LE, ME, and HE represent CHO:L ratios of 0.91, 1.92, 3.91, respectively, supplemented with the same ratio of carbohydrase. Results showed that weight gain rate (WGR) and specific growth rate (SGR) reached a maximum in group M and were significantly enhanced by carbohydrase (p < 0.05). Crude lipid content decreased significantly with an increase in the dietary CHO:L ratio (p < 0.05). Significant increases in the trypsin (TRY) and amylase (AMS) activities and significant decreases in the lipase (LPS) activity were observed with increasing dietary CHO:L ratio, and the former two were significantly promoted by carbohydrase (p < 0.05). The content of liver and muscle glycogen increased significantly with the increasing dietary CHO:L ratio but decreased significantly after carbohydrase supplementation (p < 0.05). The glucokinase (GK), pyruvate kinase (PK), Phosphate 6 fructokinase-1 (PFK-1) and phosphoenolpyruvate kinase (PEPCK) activities increased significantly with increasing dietary CHO:L ratio (p < 0.05). Glut2 mRNA expression decreased significantly in liver and increased significantly in intestine with increasing dietary CHO:L ratio (p < 0.05). By linear discriminant analysis (LDA), the abundance of Alistipe was significantly higher in Group ME than in Group M. These results suggested that hybrid grouper can only moderately utilize dietary carbohydrate and lipid in diet, and a certain amount of high glycemic lipids occurred when fed with high-carbohydrate diets. By the weight gain for basis, the supplementation of carbohydrase in Group H with amylase, glycosylase, and pullulanase in a 1:1:1 ratio effectively lowered glycemic lipids, promoted the growth of grouper, digestive enzymes activities and carbohydrate metabolic enzyme, and glut2 gene expression in intestine, effectively balancing the negative effects of high-carbohydrate diet and improving the utilization of carbohydrate.
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Temme, J. Sebastian, Dorothy L. Butler und Jeffrey C. Gildersleeve. „Anti-glycan antibodies: roles in human disease“. Biochemical Journal 478, Nr. 8 (21.04.2021): 1485–509. http://dx.doi.org/10.1042/bcj20200610.
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Carbohydrate-binding antibodies play diverse and critical roles in human health. Endogenous carbohydrate-binding antibodies that recognize bacterial, fungal, and other microbial carbohydrates prevent systemic infections and help maintain microbiome homeostasis. Anti-glycan antibodies can have both beneficial and detrimental effects. For example, alloantibodies to ABO blood group carbohydrates can help reduce the spread of some infectious diseases, but they also impose limitations for blood transfusions. Antibodies that recognize self-glycans can contribute to autoimmune diseases, such as Guillain-Barre syndrome. In addition to endogenous antibodies that arise through natural processes, a variety of vaccines induce anti-glycan antibodies as a primary mechanism of protection. Some examples of approved carbohydrate-based vaccines that have had a major impact on human health are against pneumococcus, Haemophilus influeanza type b, and Neisseria meningitidis. Monoclonal antibodies specifically targeting pathogen associated or tumor associated carbohydrate antigens (TACAs) are used clinically for both diagnostic and therapeutic purposes. This review aims to highlight some of the well-studied and critically important applications of anti-carbohydrate antibodies.
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Liu, Ruru, Baibing Mi, Yaling Zhao, Qiang Li, Shaonong Dang und Hong Yan. „Gender-specific association between carbohydrate consumption and blood pressure in Chinese adults“. BMJ Nutrition, Prevention & Health 4, Nr. 1 (13.01.2021): 80–89. http://dx.doi.org/10.1136/bmjnph-2020-000165.
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BackgroundThe association between dietary carbohydrate consumption and blood pressure (BP) is controversial. The present study aimed to evaluate the possible gender-specific association of carbohydrate across the whole BP distribution.MethodCross-sectional survey including 2241 rural adults was conducted in northwestern China in 2010. BP was measured by trained medical personnel. Dietary information was collected by semiquantitative Food-Frequency Questionnaire. Multivariate quantile regression model was used to estimate the association between total carbohydrates consumption and systolic BP (SBP) and diastolic BP (DBP) at different quantiles. Gender-specific β coefficient and its 95% CI was calculated.ResultsThe average carbohydrate intake was 267.4 (SD 112.0) g/day in males and 204.9 (SD 90.7) g/day in females, with only 10.6% of males and 6.5% females consumed at least 65% of total energy from carbohydrates. And more than 80% carbohydrates were derived from refined grains. In females, increased total carbohydrates intake was associated with adverse SBP and DBP. An additional 50 g carbohydrates per day was positively associated with SBP at low and high quantiles (10th–20th and 60th–80th) and with DBP almost across whole distribution (30th–90th), after adjusting for age, fortune index, family history of hypertension, body mass index, physical activity level, alcohol intake and smoke, energy, two nutrient principal components, protein and sodium intake. Both relatively low and high carbohydrate intake were associated with increased SBP, with minimum level observed at 130–150 g carbohydrate intake per day from restricted cubic splines. However, no significant associations were observed in males.ConclusionsHigher total carbohydrates consumption might have an adverse impact on both SBP and DBP in Chinese females but not males. Additionally, the positive association varies across distribution of BP quantiles. Further research is warranted to validate these findings and clarify the causality.
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Butki, Brian D., Jeffrey Baumstark und Simon Driver. „Effects of a Carbohydrate-Restricted Diet on Affective Responses to Acute Exercise among Physically Active Participants“. Perceptual and Motor Skills 96, Nr. 2 (April 2003): 607–15. http://dx.doi.org/10.2466/pms.2003.96.2.607.
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Currently, the carbohydrate-restricted diet is very popular. Atkins' book, Dr. Atkins' Diet Revolution, has sold millions in its more than 25 years of existence. His book promotes the carbohydrate-restricted diet, which focuses on the consumption of proteins and fats as primary calorie and energy sources, while severely restricting carbohydrates. However, when carbohydrates are restricted from the diet, the body's primary energy source is reduced considerably. Therefore, the purpose of this study was to compare the psychological responses to exercise of individuals when on a carbohydrate restrictive diet and when on a noncarbohydrate restrictive diet. For this study, 17 participants practiced a noncarbohydrate-restricted diet for three weeks and the carbohydrate-restricted diet for three weeks, while maintaining previous exercise habits. After each exercise session, the participants completed the Physical Activity Affect Scale, which measures Positive Affect, Negative Affect, Tranquility, and Fatigue. Simple one-way analyses of variance indicated significant treatment differences ( ps <.05) relative to Negative Affect, Positive Affect, and Fatigue. The results of the study indicate as predicted, that, when a person restricts carbohydrates from the diet, he will experience more fatigue, more negative affect, and less positive affect in response to exercise than those individuals who are not restricting carbohydrates.