Dissertationen zum Thema „Calum“
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1
Dutta, Sayantanee. „CALM/AF10 leukemia“. Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-174268.
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Harrop-Allin, Margaret. „Superhumps in AM Canum Venaticorum stars“. Master's thesis, University of Cape Town, 1996. http://hdl.handle.net/11427/19686.
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Bibliography: pages 205-214.The AM Canum Venaticorum stars are an in homogeneous group of six stars that are characterised by the absence of hydrogen lines in their spectra. The structure of these stars has been the subject of much debate, and single star models were considered as recently as 1992. The prevailing opinion, however, is that the A.Jf eVn stars are semi-detached binaries which consist of a low-mass, degenerate helium secondary which is transferring mass via an accretion disc to a DB white dwarf. Under this model, the orbital periods of the AM CVn systems are in the range 1000 - 3000 s. The AM CVn systems show many of the accretion disc-related phenomena that are observed in non-magnetic (hydrogen-rich) cataclysmic variables. Five of the six systems show low-amplitude optical oscillations with periods between 500 and 2000 s. The oscillations have a complex and variable harmonic structure. Since they are consistent with the predictions of the double-degenerate binary model, the oscillations were assumed to correspond to the orbital period in each system. However, the fundamental periods and their harmonics are unstable, showing amplitude and phase drifts on a time scale of weeks to months. The instability of the photometric periods has therefore been an obstacle to accepting that the AM CVn stars are binary systems. An alternative explanation was proposed by O'Donoghue & Kilkenny (1989): the photometric variations in the AM CVn stars are not their orbital periods, but are caused by the same mechanism that produces superhumps in SU UMa dwarf novae. Superhumps are optical variations observed during the superoutbursts of SU UMa stars with periods a few percent in excess of the orbital period. The superhumps usually disappear as the star declines to quiescence after a superoutburst. Superhumps are thought to be the result of periodic enhancements of tidal dissipation in the outer regions of the accretion disc. In addition to the superhumps in SU UMa dwarf novae, permanent superhumps have been observed in other hydrogen-rich cataclysmic variables. The aim of this dissertation is to present new photometric data and to explore the period structure of four of the six known AM CVn stars to see whether the observations are consistent with a superhump interpretation. The aim is also to draw comparisons between the AM CVn stars and examples of hydrogen-rich cataclysmic variables in which superhumps have been observed, and in this way to strengthen the evidence that similar mechanisms are operating in the hydrogen-rich superhumpers and the multi periodic AM CVn stars.
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Dainas, Ashley R. „Keep Calm and Study Memes“. Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1428085991.
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Tavepontakul, Natvalun. „OASIS OF CALM : A STUDY ON CREATING AN URBAN OASIS OF CALM INSPIRED BY NATURE“. Thesis, KTH, Ljusdesign, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-280033.
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We live in daily cycles of brightness and darkness throughout our lives. Light is a device, both through natural and artificial sources, that supports the working of our brains in the processing, reconstruction, and classification of information (Galetta, 2014). According to the models of mental processing provided by various individuals in literature, light as a stimulus can induce specific emotions and behaviors in people (Tomassoni et al., 2015). The objective of this thesis project is to study the possibility of using light patterns and motions to support stress reduction and provide people with a feeling of calm in an indoor setting, where access to nature is limited. The participants (n=30) of the study are students and working adults who live in different cities. They have been asked to evaluate the natural elements and what they perceive as calmness and relaxation through the projection of five different sets of skies. The study considers light as a Biophilic design element, which provides people with calm and a sense of well-being in their work environment (i.e., home office, working space). Through the results of this first survey and insight from the study, the author conducted a lighting experiment using a small model and surveyed the participants’ responses on mood and preference to the different lighting conditions in the model. Consequently, it turned out that most of the participants, from both the online survey and through direct physical interaction with the model, mentioned that they would prefer spending their breaks during their workday in a space that has both patterned light and moving light (not static), rather than the absence of light patterns and motion. By shaping human experience, the study investigates the possibility of using artificial light as a Biophilic design element to provide people with a feeling of calm and, therefore, to support stress reduction in their work environment.
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Medcalf, Kathryn Ann. „The ecology and reinstatement of Carum verticillatum“. Thesis, Aberystwyth University, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337626.
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BENYAMINE, DANIEL. „Epidemiologie des cancers du cavum dans le departement du rhone“. Lyon 1, 1989. http://www.theses.fr/1989LYO1M400.
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Moret, Henri. „La forme pseudo-tumorale de tuberculose du cavum“. Poitiers, 1988. http://www.theses.fr/1988POIT1080.
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Frey, Suzanne. „Scanographie du cavum : les aspects normaux et pathologiques“. Université Louis Pasteur (Strasbourg) (1971-2008), 1985. http://www.theses.fr/1985STR1M107.
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Pattani, Shital. „Shant(calm): a dialogue with my mother“. The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu1328122787.
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Karlsson, Frida. „Estrogenic Substances in Plastic Bottles“. Thesis, Örebro universitet, Institutionen för naturvetenskap och teknik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-37117.
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We live in a time were plastic and plastic products are all around us, taking part in our everyday life. Several chemical additives can be present in plastic products, such as plastic bottles, and can have a big impact on development, as well as on the endocrine system in adults by the binding to, and disturbance of, the estrogen receptor (ER) in cells. This study has focused on a number of different plastic bottles made from different types of plastic and with variations in size and scope of use. The aim of the study was to see if any estrogenic substances leached from the bottles into water. Non-ionic water was added to the plastic bottles, and the bottles were kept at 70°C for 72 hours. The estrogenic activity in the water was determined with the U2OS-luc assay and expressed as bioassay-derived estradiol equivalents (Bio-EEQ). A difference in Bio-EEQ could be detected between the bottles and the tree plastic types used in the study. The polypropylene (PP) bottle gave the highest Bio-EEQ of 0.5 pg/ml, whereas High Density Polyethylene (HDPE) gave 0.3 pg/ml and Polyethylene Terephthalate (PET) 0.04 pg/ml. These results indicate that there is a small leakage of estrogenic substances from the plastic bottles. Further study is needed to determine whether or not the estrogenic activity in the water could have any significant biological effect in humans.Vi lever i en tid där plast och plastprodukter finns överallt runt omkring oss och har en stor del i vår vardag. Många kemiska ämnen kan återfinnas i plastprodukter, såsom plastflaskor, och kan ha en stor inverkan inte bara på den växande kroppen hos barn utan även ge endokrina störningar hos vuxna människor. Detta kan till exempel ske genom att ämnen kan binda till och påverka östrogenreceptorn (ER) i cellerna. Den här studien fokuserar på plastflaskor gjorda av olika typer av plast och med varierande storlek och användningsområde. Syftet med studien var att se huruvida några östrogena substanser kunde lakas ut i vatten som förvarades i flaskorna. Flaskorna fylldes med avjoniserat vatten och förvarades i 70°C i 72 timmar. Östrogenaktiviteten i vattnet mättes sedan i en cellbaserad testmetod, kallad U2OS-luc assay, där den samlade biologiska effekten av alla östrogena ämnen kan mätas. Effekten uttrycks som bioassay-derived estradiol equivalents (Bio-EEQ). Vatten från polypropenflaskan (PP) gav det högsta Bio-EEQ på 0,5 pg/ml medan högdensitetspolyeten (HDPE) gav 0,3 pg/ml och polyetylentereftalat (PET) ett Bio-EEQ på 0,04 pg/ml. Dessa resultat indikerar att plastflaskorna läcker ut små mängder östrogenlika ämnen. Vidare studier behöver göras för att avgöra huruvida detta läckage utgör någon risk för människor.
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Pierce, Alden D. „Morning calm, nuclear sunset: South Korea's atomic option“. Thesis, Monterey, California. Naval Postgraduate School, 1998. http://hdl.handle.net/10945/8700.
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Approved for public release; distribution is unlimitedU.S. national security strategy sets nuclear nonproliferation as a high priority. However pursuing nonproliferation without regard for important traditional security relationships might yield undesired results. The Republic of Korea (ROK) requires a high degree of confidence in the U.S. security guarantee one that includes an extended nuclear deterrent. The nuclear weapons program that South Korea began and abandoned in the 1970s was prompted by a decrease in confidence in U.S. security commitments. Conciliatory actions taken recently by the United States toward the Democratic Peoples' Republic of Korea (DPRK) to prevent a possible nuclear weapons program may undermine the U.S.-ROK security arrangement that has been in place for decades. This work examines perceived threats to South Korea and the U.S. security commitment to Korea since 1945 to reveal how U.S. nuclear nonproliferation policy affects Seoul's propensity to develop nuclear weapons. Recommendations are provided for policy makers regarding strengthening of ROK confidence in the U.S. commitment on the peninsula, with particular emphasis on preventing South Korea from pursuing a nuclear arsenal
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Charolais, Frédéric. „Les complications de l'adenoidectomie chez l'enfant : a propos d'un cas de perforation de la paroi pharyngee posterieure“. Université Louis Pasteur (Strasbourg) (1971-2008), 1991. http://www.theses.fr/1991STR1M042.
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Petraitytė, Nijolė. „PAPRASTOJO KMYNO (CARUM CARVI L.) LIETUVOS POPULIACIJOS FENOTIPINĖ IR GENETINĖ ĮVAIROVĖ“. Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2006. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2005~D_20060116_132111-96004.
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In 1996-2000 during expeditions were found and described 123 Carum carvi habitats. Mostly common caraway is found in pasture type habitats of Cynosurion cristati confederation communities. Plants of Carum carvi cenopopulations are characterized by wide diversity of phenotypic traits strongly influenced by ecological conditions and anthropogenic activity in natural habitats. The most stable parameters are weight of 1000 fruit and biochemical composition of essential oil. Essential oil synthesis in fruits is positively affected by warm and dry weather at the stage of caraway flowering – fruit ripening, carvone content – by warm and wet weather. The identified morphological types of Carum carvi leaves were as follows: normal, dill and parsley. Early-season caraway forms in comparison to others distinguished for the lowest height, fruit weight and total yield, but had the highest carvone content in fruit essential oil. Pink petals are characteristic for early-season caraway cenopopulations. White petal color, greater pigments amount in leaves, higher fruit productivity, as well as essential oil and carvone output characterize medium late and late forms. Various caraway genotypes with different levels of leaf carotinoids, chlorophyll content and ratio, anthocianins amount in petals, different reaction to cold and lighting stress reveal specific adaptive plasticity of caraway. Caraway intercenopopulation genetic diversity was determined at the molecular level.
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ROGER, BERNARDAUD NICOLE CAROLE. „Tumeur du cavum revelee par une detresse respiratoire chez un nouveau-ne“. Limoges, 1988. http://www.theses.fr/1988LIMO0105.
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BUSSET, ROLLAND CORINNE. „Tumeurs malignes primitives du cavum de l'enfant et l'adolescent : a propos de cinq cas“. Nantes, 1992. http://www.theses.fr/1992NANT070M.
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Montgomery, June M. „From Chaos to Calm: Understanding Anger in Urban Adolescent Males“. Diss., Virginia Tech, 2010. http://hdl.handle.net/10919/37630.
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This work is based on the premise that uncontrolled anger contributes to the violence committed by adolescent boys 13-17 years of age. In fact, in all countries, young males are both the principal perpetrators and victims of homicide (World Health Organization, 2002). Identifying the underlying reasons for the anger is instrumental in controlling this emotion and in developing and implementing effective violence prevention methods that may lead to a decrease in adolescent violence. Violence in urban America committed specifically by the adolescent male is a serious problem and one that has stimulated the interest of this writer.The purpose of this dissertation is to provide classroom teachers, school administrators, counselors, and parents with insights, strategies, and techniques to understand and help the chronically angry child. Further, my purpose is to review and describe existing knowledge to provide a basis for action in managing these children. Dealing with an angry child is frustrating as well as challenging if one does not understand angerâ its possible causes and effects. Since 95% of juvenile homicides are committed by boys under the age of 18, it is fitting that this work focuses on adolescent males (Supporting Our Sons, 2003).Ed. D.
17
Owens, Chase. „A Constructional Approach to Establishing and Maintaining Calm Canine Behavior“. Thesis, University of North Texas, 2017. https://digital.library.unt.edu/ark:/67531/metadc984128/.
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Very few behavior-change programs with canines produce effects that persist beyond the training condition. The present study is an experimental demonstration of a constructional program that established calm patterns of behavior as alternatives to hyperactive ones. Three dogs that exhibited hyperactive patterns were chosen as subjects. Seven conditions common to canine-caretaker relationships were used to determine which factors resulted in the hyperactive patterns. Then, sitting and lying down were taught as beginning points using touch as a reinforcer. The final behavior, maintained by naturally occurring reinforcers, was established errorlessly. The study used a control-analysis strategy of behavior change with a changing-criterion design. The intervention resulted in an immediate reduction in hyperactivity and an increase in sitting and lying down for all dogs.
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Jennings, David John. „Performance and behaviour of the combined analogue locked-loop universal modulator (CALLUM)“. Thesis, University of Bristol, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313011.
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Machado, Selene Marinho. „Discurso sobre a pessoa idosa : vozes que falam e vozes que calam“. reponame:Repositório Institucional da UnB, 2008. http://repositorio.unb.br/handle/10482/6285.
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Dissertação (mestrado)—Universidade de Brasília, Departamento de Lingüistica, 2008.Submitted by Suelen Silva dos Santos (suelenunb@yahoo.com.br) on 2009-09-23T18:29:12Z No. of bitstreams: 1 2008_SeleneMarinhoMachado.pdf: 1231299 bytes, checksum: 7871c02bfde2fc532809b02941f7d6c4 (MD5)
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Esta pesquisa é originária de meu interesse pela questão social da pessoa idosa, que envolve uma experiência pessoal, familiar. Meu propósito é verificar a representação e as características identitárias da pessoa idosa, nos discursos do(a)s próprio(a)s idoso(a)s e de pessoas que convivem com ele(a)s e nos discursos sobre a pessoa idosa, presentes na imprensa e em dispositivos legais de proteção ao idoso. O suporte teórico-metodológico adotado é a Análise de Discurso Crítica (ADC), baseado principalmente em abordagens de Chouliaraki & Fairclough (1999) e Fairclough (trad. 2001 e 2003), com ênfase nos significados acional, representacional e identificacional dos textos. O referencial teórico é composto, ainda, por: Thompson (1995) e Foucault (2004, 2006 e 2007), nas questões de poder e ideologia; Silva (2000), Giddens (2002) e Hall (2005) nas análises sobre identidade; Halliday (1985; 1994), Halliday & Hasan (1989) e Halliday & Matthiessen (2004), na abordagem sistêmico-funcional da linguagem; Koch (2005, 2006a e 2006b) nos aspectos de argumentatividade e modalidade; e Van Leeuwen (1997), nos modos de representação presentes nos textos. A metodologia utilizada para geração dos dados é a pesquisa qualitativa e os métodos empregados foram a entrevista semi-estruturada e a entrevista narrativa. O corpus da pesquisa é constituído de fragmentos de textos extraídos do Estatuto do Idoso e de matérias veiculadas pela imprensa, sobre a questão da violência contra idosos; e por narrativas de uma idosa asilada e de uma cuidadora profissional. A pesquisa revela características identitárias de dependência, fragilidade e opressão. Das análises realizadas é possível depreender que o discurso sobre idosos é, em grande parte, ideológico, por reforçar crenças e valores hegemônicos do mundo capitalista, que desqualificam as pessoas que perderam sua capacidade produtiva. Em que pese o Estatuto do Idoso estabelecer direitos e garantias para a pessoa idosa, suas prescrições não se realizam na prática em virtude da naturalização da inferioridade do idoso em relação aos mais jovens. _________________________________________________________________ ABSTRACT
This research is the result of my interest in the elderly social issue which involves a personal and family experience. One of its main purposes is to verify the representation and identity features of old people in their discourse as well as in the discourse of people who live with them, including the discourses which are presented by the press and established in the legal provisions to protect the elderly. The methodological and theoretical approach is what is known as the Critical Discourse Analysis (CDA), based mainly in approaches to Chouliaraki & Fairclough (1999) and Fairclough (1992 and 2003). Action, representation and identification will also be emphasized. The theoretical reference will be based also on Thompson (1995) and Foucault (2004, 2006 and 2007), in what power and ideology are concerned; Silva (2000), Giddens (2002) and Hall (2005) in analyzing identity; Halliday (1985;1994), Halliday & Hasan (1989) e Halliday & Matthiessen (2004), in Systemic Functional Linguistics approach; Koch (2005, the 2006a and 2006b), in what Modality and argumentation are concerned; and Van Leeuwen (1997), in considering the modes of representation which can be found in the text. The methodology used for data generation is the qualitative research and the methods are semistructured and narrative interviews. The research material was extracted from the Elderly Law and from press news about the violence against elderly, and also from statements made by an old woman and by a caretaker. The research reveals identity characteristics of dependency, weakness and oppression. From the analyses we can conclude that the discourse about the elderly is, mostly, ideological, since it reinforces beliefs and hegemonic values of capitalism, which reduce the importance of people who lost their productive capacity. In spite of the Elderly Law establishing rights and guarantees to the elderly, its recommendations do not work in practice, because of the feeling that the elderly are inferior human beings in comparison to the young people.
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Chumpitaz, Francia Luis Angel Giovanni. „Comparación de la técnica radiográfica de “cavum boca abierta” frente a la de “cavum boca cerrada” para la determinación del diagnóstico de hipertrofia adenoidea en niños de 3 - 9 años“. Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2012. https://hdl.handle.net/20.500.12672/15099.
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Publicación a texto completo no autorizada por el autorEl cavum o nasofaringe es la región anatómica que contiene al adenoides cuya patología obstructiva se observa en la población infantil y es llamada hipertrofia adenoidea. Para evaluarla se han ideado métodos no radiológicos y radiológicos, entre los que destaca la radiografía de cavum. La variabilidad en la técnica hace que exista la duda sobre su utilidad en su más sonada discrepancia: realizarla con boca abierta y/o cerrada. Con el objetivo de comparar la técnica radiográfica de “cavum boca abierta” frente a la de “cavum boca cerrada” para la determinación del diagnóstico de hipertrofia adenoidea en niños de 3-9 años, se diseñó un estudio cuantitativo descriptivo comparativo prospectivo en el que se evaluaron las radiografías digitales de 45 pacientes que acudieron al servicio radiológico del Hospital Nacional Guillermo Almenara Irigoyen con solicitud radiográfica de cavum entre los meses de marzo y mayo del presente año. Dos médicos radiólogos midieron las distancias A y N e índice A/N de Fujioka de las radiografías en ambas tomas para analizarlas con la prueba no paramétrica “Prueba de Wilcoxon para datos pareados” en el programa informático SPSS V19.0. Al promediar la diferencia de las medidas de A, N e índice A/N de las radiografías en boca cerrada y abierta se encontró 0.842, 0.556 mm y 0.015 unidades respectivamente. Estadísticamente, para un nivel de significancia de 0.05, se comprobó que existe diferencia entre ambas técnicas respecto a las medidas realizadas para diagnosticar la hipertrofia adenoidea, siendo menores en las vistas en boca abierta. Se concluye que la radiografía de “cavum boca cerrada” es superior comparada con la de "cavum boca abierta” ya que permite realizar mediciones aproximándose al real pasaje de aire por la vía nasofaríngea. Si sólo una técnica radiológica de cavum es necesaria para evaluar la hipertrofia adenoidea, se puede elegir la de boca cerrada.
Tesis
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Spannagel, Ruven [Verfasser], Claus [Akademischer Betreuer] Braxmaier, Calus [Gutachter] Braxmaier und Andreas [Gutachter] Rittweger. „Laser-interferometric dilatometry / Ruven Spannagel ; Gutachter: Calus Braxmaier, Andreas Rittweger ; Betreuer: Claus Braxmaier“. Bremen : Staats- und Universitätsbibliothek Bremen, 2017. http://d-nb.info/1141862026/34.
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EL, GHISSASS MOHAMMED. „Mise en evidence d'une entite anatomo-fonctionnelle cerebrale : l'organe cavum pre-lamina terminalis“. Paris 11, 1990. http://www.theses.fr/1990PA112360.
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Le but de ce travail est de montrer l'individualite d'une structure cerebrale creuse: l'organe cavum pre-lamina terminalis (ocplt). Notre etude a ete concue pour montrer les particularites morphologiques et fonctionnelles de cette structure. Elle est realisee grace a plusieurs approches methodologiques. L'approche anatomique consiste a examiner des coupes seriees sans preparation et apres impregnation de l'organe par un colorant et montre que l'ocplt est forme de deux cornes: l'une est verticale et s'etale de la face inferieure du genou du corps calleux en haut, jusqu'a la face anterieure de l'organe vasculaire de la lame terminale; l'autre est horizontale et s'etend sous le corps calleux. L'approche electrophysiologique montre que les neurones en bordure de la lumiere de l'organe sont sensibles a l'angiotensine ii (aii) et au sodium. L'approche fonctionnelle montre que: i) l'injection d'aii dans l'ocplt provoque un comportement dipsique et des modifications au niveau renal avec antidiurese et antinatriurese. Cette reponse dipsique est potentialisee si l'aii est associee a la vasopressine; ii) l'injection du peptide atrial natriuretique dans l'ocplt est suivie d'une diurese et d'une natriurese; iii) l'injection du peptide yy dns l'ocplt engendre un comportement de prise alimentaire
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Reuter, Shelley Z. „"The very opposite of calm", a socio-cultural history of agoraphobia“. Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/NQ63447.pdf.
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Sen, Dity. „Characterization of the putative CALM/AF10 collaborator Meis1 in leukemia development“. Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-160708.
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Chromosomal translocations are common in human leukemias. Detailed studies of chromosomal translocation have been useful in understanding the pathogenesis and identifying therapeutic targets in hematologic malignancies. Some translocations result in the formation of fusion genes. These fusion proteins play an important role in leukemogenesis. The t(10;11)(p12;q14) translocation is rare but recurring and results in the formation of the CALM/AF10 fusion protein. Patients with this translocation have a bad prognosis.
To understand how CALM/AF10 leads to leukemia, various mouse models have been established. In a murine bone marrow retroviral transduction and transplantation model Deshpande et al. (2006) showed that mice expressing CALM/AF10 in their bone marrow cells developed an acute myeloid leukemia with a penetrance of 100% and a short latency period of 110 days. Using a transgenic mouse model, in which CALM/AF10 was under the control of Vav promoter, Peter Aplan and colleagues demonstrated that only 40% to 50% of mice developed leukemia after a long latency of 10 to 12 months. Two classical transgenic CALM/AF10 models were established in our group using the immunoglobulin heavy chain enhancer/promoter (IgH-CALM/AF10) and proximal murine LcK promoter (pLck-CALM/AF10) to drive CALM/AF10 expression. These transgenic mice did not show any leukemic phenotype even after an observation period of 15 months. Taken together these studies strongly suggest that additional collaborating factors are required for the CALM/AF10 fusion gene to induce leukemia.
Meis1, a Hox cofactor, is known to collaborate with several Hox genes and Hox fusion genes such as HOXA9 and NUP98-HOXD13. In these studies, Meis1 played a critical role in accelerating the development of leukemia. It could also be shown that MEIS1 is highly expressed in CALM/AF10 positive human leukemia cells. Therefore, I sought to determine whether the homeobox gene Meis1 collaborates with CALM/AF10 in inducing leukemia.
In order to achieve this goal, lethally irradiated non-transgenic mice were transplanted with IgH-CALM/AF10 transgenic bone marrow cells transduced with a Meis1 expressing retrovirus. The transplanted mice developed an acute leukemia with a penetrance of 100% and a median latency period of 187 days. The leukemia showed predominantly myeloid features such as the presence of myeloid marker positive cells. The myeloid blast cells infiltrated in multiple hematopoietic as well as non-hematopoietic organs. The leukemic cells were also positive for the B-cell marker B220. Cells that were positive for both lymphoid and myeloid markers, a characteristic feature of CALM/AF10-induced leukemia, were also detected in all the mice. The leukemic cells had clonal DJH rearrangements. Overall, these data suggest that the transformed cell might be an early progenitor cell capable of lymphoid as well as myeloid differentiation or that the leukemia was initiated by a B220+ IgH DJ rearranged cell with blocked lymphoid differentiation, which started a default myeloid differentiation program. By performing serial secondary and tertiary transplantations the leukemic nature of the disease could be confirmed. Colony forming cell assays showed that CALM/AF10 in collaboration with Meis1 failed to induce the transformation of hematopoietic progenitors in vitro. This could either be due to the lack of required growth factors and conditions necessary for the proliferation of the transformable cell or lack of additional events essential for progression towards leukemia development.
In conclusion, I have demonstrated that Meis1 collaborates with CALM/AF10 in inducing acute myeloid leukemia. Additional, detailed analyses of the leukemia initiating cell in these models would help to better understand the pathogenesis of CALM/AF10-induced leukemia.Translokationen treten bei humanen Leukämien sehr häufig auf. Die Analyse von Chromosomentranslokationen hat sowohl zum Verständnis der Pathogenese von Leukämien als auch zur Identifizierung von therapeutischen Zielen geführt. Manche Translokationen führen zur Bildung von Fusionsgenen. Diese Fusionsproteine spielen in der Leukämogenese eine wichtige Rolle. Das Fusionsprotein CALM/AF10 entsteht durch die seltene, aber wiederholt auftretende Translokation t(10;11)(p12;q14). Patienten mit dieser Translokation haben eine schlechte Prognose. Um zu verstehen, wie es von der Expression des Proteins CALM/AF10 zum Ausbruch der Leukämie kommt, wurden verschiedene Mausmodelle etabliert. Deshpande et al. (2006) konnten in einem Mausknochenmarktransplantationsmodell nach retroviraler Transduktion zeigen, dass die Expression von CALM/AF10 zu einer akuten myeloischen Leukämie mit einer Penetranz von 100% und einer kurzen Latenzzeit von 110 Tagen führt. In einem transgenen Mausmodell, bei dem CALM/aF10 unter der Kontrolle des Vav-Promotors exprimiert wurde, wurden von Peter Aplan und Kollegen in lediglich 40 - 50% der Mäuse nach einer langen Latenzzeit von 10 bis 12 Monaten Leukämien beobachten. In unserer Gruppe wurden zwei klassische transgene CALM/AF10-Mausmodelle entwickelt, bei denen CALM/AF10 vom Immunglobulin Heavy-Chain Enhancer Promotor (IgH-CALM/AF10) bzw. vom proximalen murinen Lck-Promoter (pLck-CALM/AF10) gesteuert wurde. Diese transgenen Mäuse zeigten auch nach 15 monatiger Beobachtungszeit noch immer keinen leukämischen Phänotyp. Zusammenfassend zeigen diese Studien, daß neben dem Fusionsgene CALM/AF10 weitere Faktoren zur Induktion von Leukämie notwendig sind. Von Meis1, einem Hox–Kofaktor, ist bekannt, dass es mit mit einigen Hox Genen und auch Hox Fusionsgenen, wie HOXA9 und NUP-HOXD13, kollaboriert. In diesen Studien spielte Meis1 eine wichtige Rolle in der Beschleunigtung der Leukämieentwicklung. Ebenfalls konnte gezeigt werden, daß MEIS1 in CALM/AF10 positiven humanen Leukämiezellen sehr hoch exprimiert wird. Aufgrund dieser Beobachtungen beschloss ich nachzuweisen, ob das Homeoboxgen Meis1 mit CALM/AF10 bei der Leukämieentwicklung kollaboriert. Um dieses Ziel zu erreichen, wurden letal bestrahlte, nicht transgene Mäuse mit IgH-CALM/AF10 transgenen Knochenmarkszellen transplantiert, die mit Meis1 exprimierendem Retrovirus transduziert wurden. Die transplantierten Mäuse entwickelten eine akute Leukämie mit einer Penetranz von 100% und einer mittleren Latenzzeit von 187 Tagen. Die Leukämie zeigte vorwiegend myeloische Eigenschaften mit myeloischen Oberflächenmarkern. Die Blasten infiltrierten sowohl hämatopoetische als auch in nicht hämatopoetische Organe. Die Leukämiezellen waren ebenfalls positiv für den B-Zellmarker B220. Auch Zellen, die sowohl für lymphoide als auch myeloische Marker positiv waren – dies ist ein charakteristisches Zeichen für CALM/AF10 induzierte Leukämie – wurden in allen Mäusen gefunden. Die Leukämiezellen hatten klonale DJH Umlagerungen. Insgesamt lassen diese Daten den Schluss zu, dass die transformierte Zelle eine frühe Vorläuferzelle sein könnte, die sowohl zur lymphatischen als auch zur myeloischen Differenzierung fähig ist oder daß die Leukämie in einer B220+ IgH DJ rearrangierten Zelle mit blockierter lymphatischer Differenzierung entstanden ist, bei der das Standardprogramm der myeloischen Differenzierung abgerufen wurde. Durch Transplantation in sekundäre und tertiäre Rezipientenmäuse konnte bestätigt werden, dass es sich in der Tat um eine Leukämie handelte. Im Colony Forming Cell-Assay hingegen führte die Kollaboration von CALM/AF10 mit Meis1 nicht zur Transformation von hämatopoetischen Vorläuferzellen. Dies könnte zum einen daran liegen, dass notwendige Wachstumsfaktoren und Wachstumsbedingungen für die Proliferation der transformierbaren Zellen fehlten, oder, dass zusätzlichen genetische Ereignissen, die für die Leukämieentstehung essentiell sind, nicht vorhanden waren. Zusammenfassend konnte ich zeigen, daß Meis1 mit CALM/AF10 bei der Induktion der akuten myeloischen Leukämie kollaboriert. Zusätzliche, detailliert Analysen der Leukämie induzierenden Zellen in diesem Modell würden helfen, die Pathogenese der CALM/AF10 induzierten Leukämie besser zu verstehen.
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Elshiekh, Haitham Abdalla. „Maneuvering characteristics in calm water and regular waves for ONR Tumblehome“. Thesis, The University of Iowa, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=1560644.
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Standard maneuvering tests were executed at the IIHR wave basin using free-running model. Experiments in calm water as well as wave were performed for a surface combatant with primary focus on establishing a validation benchmark dataset for an unsteady Reynolds-averaged Navier-Stokes (RANS)-based computational fluid dynamics (CFD) code used for computing both air and water flow around a ship. Experimental data from this study will also be used in developing a mathematical model for computing the external forces exerted on the ship model during maneuvering. The geometry is 1/49 scale fully appended ONR Tumblehome model 5613, with a length of 3.147 m. Tests are performed in 20 x 40 x 4.5 m wave basin which is equipped with six plunger-type wave makers, free-running system, as well as carriage tracking system. The maneuvering tests included course keeping, zigzag, and turning tests in head and following waves as well as calm water. Course keeping and zigzag tests were performed at Froude number 0.2 while turning tests were performed at Froude numbers 0.1, 0.2, and 0.3. While the wave height to wavelength ratio was held constant at 0.02 for all the test cases, experiments were performed at three different wavelengths for each Froude number case at different wave encounter angles. Maneuvering trajectories for each test as well as results such as roll, pitch, yaw and yaw rate results were analyzed for all tests. Drift angle, drifting distance, tactical diameter, advance and transfer results from turning tests were obtained and tactical diameter and advance are compared to other facilities data. 1st and 2nd overshoot angles results from zigzag tests and counter rudder angle and speed loss in course keeping were obtained and documented along with the turning test results to help in developing a mathematical model for calculating the forces and moments acting on the ship model and to establish a benchmark data for the CFD validation use.
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Talabova, Kristina. „Keep calm and Die : Political satire in advertising, lessons from Slovakia“. Thesis, Jönköping University, Internationella Handelshögskolan, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-49007.
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Background: In the age of Millennials, when traditional advertising no longer holds the same power as before, an interesting trend has developed. Controversial politicians are on the rise and for-profit companies are starting to realize the opportunity to reach the hearts of Millennials with the use of political satire in advertising. Problem: Political satire in advertising has not yet been properly conceptualized and the related studies focus rather on its effectiveness in terms of virality. However, this controversial format of advertising needs to be studied in terms of consumer attitudes and several studies here provide mixed results depending on other considerations. Purpose: This thesis aims to explore attitudes of Millennials towards political satire in advertising used by for-profit companies together with related considerations and so to answer the question whether this format could be effective among the generation of Millennials. Method: The research takes exploratory qualitative design and combines two data streams. Data in the form of Facebook comments at the page Zomri where the satirical ads were posted were reinforced by data from three focus groups. Thematic analysis was then used to analyze them and compare them with the developed theoretical model. Given the controversial topic, ethical considerations were emphasized. Results: The findings confirm the need for a more complex perspective on political satire in advertising and validate the developed theoretical model. This format of advertising is capable to induce positive attitudes towards the ads, but more considerations play the role in attitudes towards the brands owned by for-profit companies. These include credibility of the company, message-specific factors and consumer-specific factors.
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Venditti, Silvia. „Shared resources, calm appliances. Sustainable interaction and care in housing context“. Thesis, Malmö högskola, Fakulteten för kultur och samhälle (KS), 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-21877.
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Today’s environment conditions have reached a critical stage that challenges us to revertthe current paradigm of production and waste into new ways to fulfill needs. The wholesociety needs a shift away from the individual ownership, being it one big reason of environmentalcrisis.This thesis project is an exploration into the field of sustainability in housing contexts thatseeks a different approach in the matter by encouraging the collective use of resources.The resulting design is a product service system that uses indeed a combination of artifactsand services to enhance and augment behaviors towards sustainability, by usingcalm technology as main touchpoint with the users. This means that the project tries toestablish a dialog with the user at a level that presents a valuable aesthetic of interactionbecause of the fluency of communication.
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Ista, Willem Gerrit. „Comfortably calm soothing sedation of critically ill children without withdrawal symptoms /“. [S.l. : Rotterdam : The Author] ; Erasmus University [Host], 2008. http://hdl.handle.net/1765/13430.
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Ong, Hui Xin. „TRANSPORT MECHANISMS OF INHALED CIPROFLOXACIN FORMULATIONS ACROSS CALU-3 LUNG EPITHELIA“. Thesis, The University of Sydney, 2013. http://hdl.handle.net/2123/9474.
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The main aim of this work was to investigate and understand the determinants that influence drug absorption across the lung epithelium by focusing on different formulations of ciprofloxacin as a potential inhaled treatment for respiratory tract infections. The transport of inhaled therapeutics follows a series of processes whereby following deposition, aerosol drug particles are wetted, dissolve and diffuse into the apical surface liquid for subsequent absorption across the lung epithelium. To mimic the bolus inhalation in vivo, the twin stage impinger was used in vitro to deposit formulations onto air interface Calu-3 bronchial epithelial cells. In this thesis, the dissolution of ciprofloxacin in the epithelial lining fluid was influenced by a number of factors including drug crystalinity, timing and sequence of drug administration, salt selection, formulation properties, solubility and pH in the epithelial lining fluid. In general, the rate of the overall transport process was governed by the rate of particles dissolution/drug release into the apical lining fluid and subsequent permeability across the pulmonary epithelial cells. These studies have provided an insight into the different factors that could influence drug absorption and reinforce the potential of using in vitro cell culture models as a platform to elucidate the interactions and mechanisms of transepithelial transport, enabling the development of safe and effective inhaled therapeutics.
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Andersson, Matilda. „The Slow Regard of Silent Things“. Thesis, KTH, Arkitektur, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-223224.
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It is time for a library that does not hold all the knowledge. A library that rather deals with very well thought out collections, where you cannot check on the internet before you arrive and find out exactly where the book you want is placed, where you will actually have to browse, to find it, work for your accomplishment and there by add value to it. Perhaps find something different, something you weren’t specifically looking for. A library with a carefully changing selection of knowledge, like curating books.
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Mulaw, Medhanie Assmelash. „Early target genes of CALM/AF10 as revealed by gene expression profiling“. Diss., kostenfrei, 2009. http://edoc.ub.uni-muenchen.de/10480/.
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O'Donoghue, Thomas. „The dynamic behaviour of a surface hose attached to a calm buoy“. Thesis, Heriot-Watt University, 1987. http://hdl.handle.net/10399/1045.
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Lee, Mary E. „Making connections, teachers and students experiencing the career module in CALM 20“. Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0008/NQ59995.pdf.
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Eliasson, Sandra. „Connections between household adn street : Social, calm, safe and intimate - Tool housing“. Thesis, Umeå universitet, Arkitekthögskolan vid Umeå universitet, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-72674.
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Robinson, Timothy Donald. „Cool, calm and collected : the buffering effect of head cooling on stress“. Thesis, University of Canterbury. Psychology, 2012. http://hdl.handle.net/10092/10730.
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Most people would like to be less stressed. With our increasingly fast paced
and busy lives it appears that stress related issues are increasing, with the addition of
issues such as terrorist attacks, stress at times can be hard to avoid. Many studies have
found that cooling the brain is beneficial for those who have sustained traumatic brain
injuries and the process of cooling can often stop or prevent further damage (Qui et al,
2006). The body may also use a natural cooling mechanism, yawning, as a way of
keeping the brain at optimum temperature, so it can perform at its best (Gallup &
Gallup, 2008).There seems to be very little research on the effects of head cooling on
psychological variables. It was hypothesised that cooling would reduce stress levels
and when put in conjunction with a self-affirmation manipulation would decrease
stress levels even further. Participants had their ear temperature measured, filled out a
stress questionnaire and then were asked to sit in between two fans for 12 minutes.
Their ear temperature was measured again, they then went on to complete another
questionnaire, some containing a self-affirmation manipulation and then went on to a
stressor task. Lastly, they received a final stress questionnaire. Results were
nonsignificant, yet general trends headed in the hypothesised direction. The
implications of the findings are discussed as are limitations and suggestions for future
research.
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Zhou, Zhengquan. „A theory and analysis of planing catamarans in calm and rough water“. ScholarWorks@UNO, 2003. http://louisdl.louislibraries.org/u?/NOD,45.
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Thesis (Ph.D)--University of New Orleans, 2003.Title from electronic submission form. "A dissertation ... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Engineering and Applied Science"--Dissertation t.p. Vita. Includes bibliographical references.
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Walker, Mike. „Object-images : the exposed paintings of Callum Innes and the phenomenology of non representational painting“. Thesis, University of Kent, 2017. https://kar.kent.ac.uk/62716/.
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This thesis seeks to explore the notion of non-representation in painting and consider our experience of such paintings in phenomenological terms. It is centred around an analysis of the Exposed Paintings by Callum Innes, made from 1993 to date, and employs the term object-image to examine how such paintings make a viewer aware of their material actuality or corporeality. It considers object-images in relation to the theory and practice of American art in the middle of the twentieth century as well as British painting and sculpture of recent decades. The main section of the thesis draws upon the writing of Maurice Merleau-Ponty to ask questions of our perceptual experience of non-representational paintings especially in relation to the idea of the reciprocity of viewer and viewed.
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VILLENAVE, SABRINA. „KEEP CALM AND CARRY ON: THE INSTRUMENTALIZATION OF MEMORY IN THE MODERN STATE“. PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2011. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=19081@1.
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PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIROUma característica comum ao Estado Moderno é um passado de conflitos e violência. A relação entre esta violência e, muitas vezes, o trauma que decorre dela, irá determinar como será articulada a relação com a memória/esquecimento no momento após os conflitos. Falar de memória não é apenas falar sobre o passado. Falar em memória é também falar do presente e das articulações que resultaram neste presente. Tendo como exemplos a Ex-Iugoslavia e Ruanda é possível se perceber como o Estado Moderno atua através de práticas de memória na monumentalização, na educação e ao trazer uma confrontação com o passado para a construção de uma sociedade homogênea.
A common feature of the modern state is a past of conflict and violence. The relationship between this violence and, often, the trauma that follows it, will determine how the relationship of remembering/forgetting is going to act in the moment after the conflict. Talking about memory is not just to talk about the past. Talking about memory is also to talk about the present. Taking as examples the Former Yugoslavia and Rwanda it is possible to analyze how the modern state acts through the memory practices at monumentalization, education and practices of confrontation with the past for the construction of a homogeneous society.
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Molenaar, Daryn. „Perception of information : enriching location specific information through the use of calm computing“. Thesis, Cape Peninsula University of Technology, 2011. http://hdl.handle.net/20.500.11838/2276.
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Thesis (MTech (Design))--Cape Peninsula University of Technology, 2011.Many studies have been conducted on the interaction between environments and relevant information in the field of interaction design. Most of these studies are focused on increasing the awareness of technology, information and the interaction between them. This awareness could negatively lead to an increase in information overload where each bit of information is competing to be the centre of a person's attention. This information overload gets compounded even more when a person is in a public place because of the amount of available commercial information like billboards, digital displays and printed media which are constantly pushing information into the space. Cognitive studies have shown that human beings have a limit to the amount of information they can consciously focus on and process. When a person reaches information saturation, the quality of their decision-making ability deteriorates drastically (Bray, 2008). Information overload can lead to a situation called decision paralysis. The research proposed an investigation into the possibility of decreasing information overload through the use of calm computing. Relevant information could be pushed to the periphery where it could be accessed or attended to when it was needed. It was argued that when the intake of peripheral information could become an unconscious activity, mainly through the use of ubiquitous computing, more attention could be given to other important activities like increasing social interaction in public spaces.
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Tokita, Tamaki. „Cool, Calm and Collected?: Literary Images of Japan Following the 2011 Triple Disaster“. Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/15372.
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The impact of the 2011 Tōhoku earthquake and tsunami that hit Japan on the 11th of March (3.11) extended far beyond the physical damage produced, prompting a myriad of political and cultural responses worldwide. The Japanese government and authorities, as well as mainstream international media, focused on the narrative of a disciplined, resilient and composed nation, with a vibrant community spirit, united in the face of the disaster. However, it is also true that the disaster sparked widespread public interest in the negative aspects of Japanese society. Left-wing activists and social commentators blamed the government as well as post-war Japanese systems and values for the manmade aspect of the disaster, namely the unresolved situation at the nuclear power plants in Fukushima. Spurred by the heightened emotions following the triple disaster, Japanese society has become increasingly polarized between these two views of how to represent itself. How has literature responded to this conflict? This thesis will examine this issue through an analysis of literary images portraying Japanese identity in post-3.11 literature. Texts will be selected from the Japanese, English and French languages, and the images will also be compared with images of Japanese identity from official government discourse and social commentators, in order to analyse how authors have been creatively adding new elements to the debate and providing alternative visions for Japan's future, in a way that was not achieved by non-literary media. I will argue that 3.11 literature has a significant role to play in mediating between radical views and creating new images for post-3.11 Japan.
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Abudiak, Hani. „Effect of fluoride sustained slow-release devices on fluoride, phosphate and calcum levels in plaque biofilms“. Thesis, University of Leeds, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.446094.
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Couser, Patrick. „An investigation into the performance of high-speed catamarans in calm water and waves“. Thesis, University of Southampton, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390187.
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Rahman, Nahian. „Creating a Sense of Presence in Remote Relationships : A concept of Calm Ambient artifact“. Thesis, Linnéuniversitetet, Institutionen för skog och träteknik (SOT), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-101721.
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Loneliness is a growing social problem that affects people from different age groups. Studies have shown that loneliness is prevalent more in young adults and the elderly demographic. Loneliness can pose serious health issues like cognitive malfunction, heart disease, stroke, depression, etc. People who stay alone from friends and family tend to feel lonelier. Conventional communication tools like a phone or video calls or using social media applications can help the users connect with people but also have adverse effects. As a result of this, the potential of an alternative nonverbal mode of communication needs to be explored. The research aims to understand individuals' behavior, traits, and hidden needs when it comes to loneliness. The purpose is to suggest an alternative way of communication that creates a sense of presence and ensures mental well for the people living alone and suffer from emotional loneliness. The concept of Calm and ambient technology has been explored in this thesis as an alternative means of communication. Users’ needs were gathered from eight semi-structured interviews, and two stakeholders were identified. Over forty ideas were generated from brainstorming. The ideas were sent to twenty individuals through snowballing. The response from them was analyzed and narrowed down by using concept screening and concept scoring. The final concept was a device called ‘One home lamp.’ The device uses light to show the presence of remote family members or loved ones to a person living alone. This concept product was then evaluated through ‘Mankoff’s heuristics’ to see its credibility as a calm ambient artifact.
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Monteiro, Melo Kauã. „The impact of body-movementbased interaction on engagement of peripheral information displays : A case study“. Thesis, KTH, Skolan för elektroteknik och datavetenskap (EECS), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-276242.
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With the growth of ubiquitous computing, people are getting familiar and receptive to the idea of using non personal devices in public spaces. An example of such a possible device are the large ambient displays which can be found in airports, subway stations, malls, and bus stops. While most of these devices are not interactive, some offer interaction through touchscreen. This study explored the impact of body-movement-based interaction on engagement of a peripheral information display. We developed and exhibited two versions of the same peripheral information display in a public space. The first version offered interactivity while no interaction was available in the second version. We counted the number of people who watched/interacted with the displays and timed how long they spent doing so. Qualitative data was also gathered through semi structured interviews and non-participant observations. The statistical analysis provide evidences that the mean time spent watching/interacting with the peripheral information display is higher when there is interaction. We are 95% confident that the interval from 0.25 to 13.71 seconds contains the difierence of mean time spent watching/interacting with the display between the two versions. The interviews and observations indicated that the interaction implemented is easily understandable by the public in few seconds without the need of instructions.Med framväxten av ubik datateknik blir människor allt mer bekanta och mottagliga för att använda allmänt tillgängliga enheter i det offentliga rum. Ett exempel på en sådan enhet är dom stora bildskärmar som placerats på flygplatser, tunnelbanestationer, köpcenter och busshållplatser. Dom flesta av dessa är inte interaktiva, men några är interaktiva genom touch. Denna studie utforskar effekten av kroppsrörelse-baserat interaktion på människors engagemang med perifera informationsskärmar. Vi utvecklade och ställde ut två versioner av en informationsskärm i ett offentligt rum. Den första versionen var interaktiv medans den andra var statisk. Vi räknade antalet människor som uppmärksammade/interagerade med informationsskärmen och tog tiden på hur länge dom eventuellt stannade. Kvalitativ data samlades genom intervjuer genom semistrukturerade intervjuer och icke-deltagande observationer. Statistisk analys av data ger underlag för att säga att medelvärdet för tid spenderat framför informationsskärmen var högre när den var interaktiv. Med ett konfidensintervall på 95% slår vi fast att skillnaden i medelvärde för tid spenderat engagerad med informationsskärmen ligger mellan 0,25 och 13,71 sekunder för dom två versionerna. Intervjuer och observationer pekar mot att den implementerade interaktionen är lätt att förstå inom loppet av några få sekunder utan behov av instruktioner.
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Martins, José Daniel Posada Vilas Boas. „Sofinare-workflow management, a case study: a web database application development“. Master's thesis, Universidade da Beira Interior, 2012. http://hdl.handle.net/10400.6/2000.
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A web-based application has been developed to ensure recording of all details of maintenance
works carried out at SOFINARE (a Portuguese aeronautical company meeting EASA PART 145
standards). The main objective is to have a safe and easy-to-use system to control and retain
maintenance work records. This application is just the beginning of a future software that
later will be developed by Grupo7Air engineers to be used in their organisation covering
specific aspects such as having all maintenance information (aircrafts, technicians, manuals,
maintenance programmes, works, inventory, component tracking, etc.) stored in a vast group
of tables, which will form the database, in a way that, any data one wants to know can be
picked up in those tables through the Software.
This research was carried out at AEROTÉCNICA and SOFINARE, both Portuguese
aeronautical organisations, with the purpose of analysing the maintenance process and also to
study how a software implementation can be done to controlling the maintenance process in
the aeronautical maintenance industry. Later on, this software can be continuously developed
and upgraded to be widely used in the entire Grupo7Air organisation, to help through the
maintenance management while complying with the existent aeronautical legislation
requirements, while ensuring aircraft maintenance planning is efficient and accurate, and, at
the same time, helping the needs of the company to survive, that is, being able to keep
making money in the present crisis.
This work begun by planning how the database should be created in order to save
maintenance organisation data safely and correctly, so it can be used later to future software
tasks.
This application has been developed (and it will continue to be) using PHP open
source language and MySQL database resource. The use of PHP and MySQL as the developing
programming languages allow this software to be a multiple platform software in a time
saving way, since the source code is recognized by the different browsers, that is, it works on
Internet Explorer, or Mozilla Firefox for example, being these, the favorite browsers of the
company’s staff, running under Windows, OS X or Linux. Implementing and learning the
software through one’s favorite browser is thus simplified, it doesn’t have to be installed in
each employee PC and also reduces implementation costs. The PC has only to be able to
connect to the internal server and have access to internal database where all data are safely
stored through this application.Esta dissertação reflete a pesquisa levada a cabo nas instalações das empresas de manutenção aeronáutica Sofinare e Aerotécnica. Ambas empresas fazem parte do Grupo7Air, um grupo que incide totalmente na área da aeronáutica. A Aerotécnica está interessada em iniciar um grande projeto, que incide na criação de um software que contemple todas as empresas do Grupo7Air, tendo sobretudo em conta que este grupo é constituído por empresas certificadas EASA-Part 145 (manutenção), Part-M (gestão da aeronavegabilidade), Part-21 (projeto/design) e Part-147 (formação de Técnicos de Manutenção Aeronáutica). Pretende-se criar uma aplicação que possa gerir toda a informação com que as empresas do grupo trabalham diariamente, ou seja, gerir toda a informação relativa à manutenção aeronáutica (programas de manutenção, componentes, sub-componentes e o seu rastreio, diretivas, ferramentas, material em armazém, etc.), de tal modo que haverá a necessidade da existência de uma grande base de dados alojada num servidor, sendo constituída por inúmeras tabelas que terão toda a informação armazenada. Atualmente a Aerotécnica (juntamente com a Aerovip), dado o seu âmbito na indústria de manutenção aeronáutica, possui uma aplicação designada por C.A.L.M.: um poderoso software que lhes permite inúmeras vantagens, tornando-se uma ferramenta essencial para o trabalho do seu dia-a-dia. No entanto, para além do seu elevado custo, apresenta algumas limitações que se pretendem eliminar, tais como: haver a necessidade de instalar o software em todos os computadores da empresa onde é necessário usá-lo. Por isso, concluiu-se que uma ferramenta que funcionasse através da web (aplicação-web) seria o ideal, estando cada trabalhador da empresa à distância de um simples browser para gerir ou consultar qualquer informação que lhe fosse necessária, sem haver a necessidade de ter que instalar a aplicação em todos os computadores da empresa. Além disso, é pretendido uma aplicação que desempenhe todas as funções do CALM e mais outras funções que surgirão do interesse da empresa, sendo que o código do Software poderá ser alterado, visto que será open-source, e constantemente atualizado, de maneira a cobrir os interesses da empresa. Nesta dissertação, estudou-se um possível começo do desenvolvimento deste software e da sua base de dados, que já pudesse ajudar o pessoal da Sofinare a registar informaticamente a abertura e fecho de Ordens de Trabalho.
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Tesson, Yves. „Les cancers du cavum, experience du centre oscar lambret : 155 cas de janvier 1971 a decembre 1985“. Lille 2, 1990. http://www.theses.fr/1990LIL2M091.
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Sulas, Gianni. „Evaluation of green algae deployment for organic pollutant removal in urban wastewater through ERE-CALUX potency assessment“. Master's thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amslaurea.unibo.it/7790/.
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The interest of the scientific community towards organic pollutants in freshwater streams is fairly recent. During the past 50 years, thousands of chemicals have been synthesized and released into the general environment. Nowadays their occurrence and effects on several organism, invertebrates, fish, birds, reptiles and also humans are well documented. Because of their action, some of these chemicals have been defined as Endocrine Disrupters Compounds (EDCs) and the public health implications of these EDCs have been the subject of scientific debate. Most interestingly, among those that were noticed to have some influence and effects on the endocrine system were the estrone, the 17β-estradiol, the 17α-estradiol, the estriol, the 17α-ethinylestradiol, the testosterone and the progesterone.
This project focused its attention on the 17β-estradiol. Estradiol, or more precisely, 17β-estradiol (also commonly referred to as E2) is a human sex hormone. It belongs to the class of steroid hormones.
In spite of the effort to remove these substances from the effluents, the actual wastewater treatment plants are not able to degrade or inactivate these organic compounds that are continually poured in the ecosystem.
Through this work a new system for the wastewater treatment was tested, to assess the decrease of the estradiol in the water. It involved the action of Chlorella vulgaris, a fresh water green microalga belonging to the family of the Chlorellaceae. This microorganism was selected for its adaptability and for its photosynthetic efficiency.
To detect the decrease of the target compound in the water a CALUX bioassay analysis was chosen.
Three different experiments were carried on to pursue the aim of the project. By analysing their results several aspects emerged.
It was assessed the presence of EDCs inside the water used to prepare the culture media.
C. vulgaris, under controlled conditions, could be efficient for this purpose, although further researches are essential to deepen the knowledge of this complex phenomenon.
Ultimately by assessing the toxicity of the effluent against C. vulgaris, it was clear that at determined concentrations, it could affect the normal growth rate of this microorganism.
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Bickel, Kelly Woolaway. „An empirical test of calm for PD a computer-administered learning module for panic disorder /“. Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1187198889.
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Romero, Camilo. „CALM : centro arqueológico La Muralla : arquitectura para la protección y difusión del patrimonio arqueológico chileno“. Tesis, Universidad de Chile, 2013. http://www.repositorio.uchile.cl/handle/2250/115718.
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ArquitectoChile es un país con historia Arqueológica. En1878 se organiza el primer grupo de estudiosos que dedicaron su tiempo a esta disciplina, indispensable como herramienta para conocer el pasado y nuestra historia. Esta “Sociedad Arqueológica de Santiago” publicó en 1880 el primer y único numero de la revista “Sociedad Arqueológica” Mucho tiempo ha pasado desde ese numero, pero la sed por conocer nuestro pasado se ha mantenido a través del tiempo. Hoy, cada día se forman mas y mas profesionales en el área de la Arqueología, y las investigaciones han llegado a descubrir hallazgos trascendentales aquí mismo en nuestro territorio. CALM es un proyecto que busca tomar la disciplina de la Arqueología y entregársela al publico común, con el fin de crear cultura y consciencia; para proteger y entender el valor patrimonial que yace bajo nuestros pies.
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Masséus, Jonatan. „Where Did The Car Go? : Smart cities, calm technology and the future of autonomous cars“. Thesis, Internationella Handelshögskolan, Jönköping University, IHH, Informatik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-50202.
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Urbanization has been a growing trend in the past fifty years. Cities are now transforming into smart cities, spaces whose infrastructure comprises an embedded digital layer. Hardware collects real-time data in the urban environment and software elaborates it to improve all types of services, from traffic to waste management to well-being. One technology that is expected to use this digital layer to further change the urban environment is the autonomous car. The purpose of this dissertation is to explore what key design attributes future autonomous cars should possess if they have not only to co-exist with and be accepted by people in the landscape of tomorrow’s smart cities, but also what they should not possess in order not to cause any harm. In this sense, the dissertation recognizes calm technology to be necessary in the design of a future autonomous car to support a human-centered, as opposed to a car- or technology-centered, environment. A socio-technical and systemic lens is applied to the phenomenological investigation of nine companies carried out by means of twelve in-depth semi-structured interviews with experts working within the automotive sector, the smart city industry, and calm technology. Eight attributes (safety, on-demand, geo-tracking, sharing, multiple purposes, communication through smart devices, electrical care and IoT/connectedness) are identified as necessary for future autonomous cars to implement in order to take advantage of the smart city infrastructure and provide a human-centered experience. Additionally, six out of the eight calm technology principles recognized in literature are considered necessary when designing future autonomous cars.