Dissertationen zum Thema „C.020.673.440“
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Huang, Xiaohua 1973. „Palladium-catalyzed C-C, C-N and C-O bond formation“. Thesis, Massachusetts Institute of Technology, 2003. http://hdl.handle.net/1721.1/29639.
Der volle Inhalt der QuelleVita.
Includes bibliographical references.
New methods for Pd-catalyzed cross-coupling reactions of aryl halides or arenesulfonates are described. Key to the success of these transformations is the proper choice of ligand and reaction conditions. Palladium catalysts supported by bulky, monodentate phosphine ligands with a biaryl backbone or the bidentate ligand, Xantphos, effectively promote the formation of ca-aryl carbonyl compounds. Base-sensitive functional groups are better tolerated when a weak base, such as K3PO4, is used. One of the most difficult transformations in Pd catalysis, the intermolecular C-O bond formation between primary alcohols and electron-neutral or even electron-rich aryl halides, was effectively promoted by the use of a new generation of ligands, 3-methyl-2-di-t-butylphosphinobiaryl. The one-step synthesis of ligands from cheap starting materials, as well as the mild reaction conditions employed for the coupling reactions, enables the practical use of Pd catalysis to access aryl alkyl ethers for the first time. Continuing study of Pd-catalyzed C-N bond-forming processes using biaryl monophosphine ligands led to the discovery of a structural derivative of these ligands, 2-dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl. This ligand, in combination with a Pd source, produces a catalyst system with both a greater degree of activity and of stability than those that use our previous ligands. Substrates that were not amenable to Pd catalysis previously are reexamined using this new catalyst system, and excellent results are obtained.
by Xiaohua Huang.
Ph.D.
Raghuvanshi, Keshav. „Ruthenium(II)-Catalyzed C-N, C-O and C-C Formations by C-H Activation“. Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2017. http://hdl.handle.net/11858/00-1735-0000-002B-7D4C-2.
Der volle Inhalt der QuelleVoigtländer, David. „Neue Platin-katalysierte C-C- und C-O-Verknüpfungsreaktionen“. [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=961741740.
Der volle Inhalt der QuelleQian, Xin. „Cobalt-Catalyzed C-C and C-N Coupling reactions“. Phd thesis, Ecole Polytechnique X, 2013. http://pastel.archives-ouvertes.fr/pastel-00943479.
Der volle Inhalt der QuelleLuyten, Marcel Andre. „Zur Synthese von (c,c,c,t)-[5.5.5.5]Fenestran /“. [S.l : s.n.], 1985. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.
Der volle Inhalt der QuelleLiu, Weiping. „Ruthenium- and Manganese-Catalyzed C−O and C−C Formation via C−H Activation“. Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2016. http://hdl.handle.net/11858/00-1735-0000-0028-8771-3.
Der volle Inhalt der QuelleFabris, Massimo <1980>. „Innovative green methodologies for C-C, C-N and C-O bond forming reactions“. Doctoral thesis, Università Ca' Foscari Venezia, 2011. http://hdl.handle.net/10579/1096.
Der volle Inhalt der QuelleIn this PhD thesis it is presented the use of some Green Chemistry Tools (supercritical carbon dioxide, ionic liquids and dialkylcarbonates) for the set up of new green methodologies for C-C, C-N and C-O bond forming reactions. The following reactions have been investigated: the self-metathesis of 1-octene catalysed by supported Re oxide systems, carried out using dense CO2 as solvent; the Michael addition of nitroalkanes and beta-diketones to alpha,beta-unsaturated ketons catalyzed by task specific phosphonium based ionic liquids; the selective mono-hydroxyalkylation of anilines with glycerol carbonate catalysed by alkali metal exchanged faujasites; the selective bis-N-methylation of anilines carried by dimethylcarbonate prepared in situ via the transesterification of alkylene carbonate with methanol catalysed by alkali metal exchanged faujasites; the alkylation of primary aromatic amines with alkylene carbonates, catalysed by phosphonium based ionic liquids; the decarboxylation reaction of dialkyl carbonates catalyzed by different heterogeneous systems; the reaction of glycerol carbonate with phenol, in the presence of faujasites as catalysts.
Pagès, Lucas. „Hydrofonctionnalisation d'allénamides terminaux par catalyse au cuivre : formation de liaisons C-C, C-S, C-P et C-O“. Electronic Thesis or Diss., Montpellier, Ecole nationale supérieure de chimie, 2022. http://www.theses.fr/2022ENCM0017.
Der volle Inhalt der QuelleOne of the main objective of the thesis is to discover new economic, non-toxic and non-polluting processes for the synthesis of targets with high added value (in the field of pharmacy and materials), starting from simple starting molecules (possibly issues from the plant world). These new processes will mainly use homogeneous catalysis and inexpensive and low-cost metal catalysts based for example on copper (the methods that these new processes are intended to replace generally make use of very expensive and highly toxic palladium based catalysts and sophisticated ligands). The research will be based on the expertise of the host team in the field of hydrofunctionalization (ref 1) of unsaturated bonds (including hydroamination) as well as in the arylation of carbon, oxygenated or nitrogenous nucleophiles (ref 2) by copper catalysis (formation of C-C and C-heteroatom bonds). The project will include a synthesis methodology part as well as a very advanced mechanistic study of the discovered catalytic systems (NMR, kinetic studies, isolation of intermediate metal complexes, DFT calculations). Application and transfer to industry, where the team has a great deal of experience, will then be considered and implemented if necessary. 1. a) Chem. Comm, 2015, 51, 11210. b) Org. Lett. 2015, 17, 1224. c) Org. Lett. 2016, 18, 1482. d) Adv. Sytnh. Cat., 2017, 349, 4388. e) ACS. Catal. 2017, 7, 425. f) Org. Lett. 2018, 20, 223. g) Synthesis, 2019, 51, 1225. 2. a) Angewandte Chemie, 2007, 46(6), 934. b) Angew. Chem. Int. Ed. 2009, 48, 337. c) Angew. Chem. Int. Ed. 2009, 48, 6954. d) Angew. Chem. Int. Ed. 2009, 48, 8725. d) Angew. Chem. Int. Ed. 2012, 51, 12815. e) Chem. Comm, 2013, 49, 7412. f) Angewandte Chemie, 2015, 54, 1058. g) Angewandte Chemie, 2016, 55, 3785
Hu, Ying. „C/C++ preprocessing directive analysis“. Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ65583.pdf.
Der volle Inhalt der QuelleCáceres, Salazar Jorge Cristián, und Acuña Patricio Carreño. „C&C Power Technologies“. Tesis, Universidad de Chile, 2015. http://repositorio.uchile.cl/handle/2250/137038.
Der volle Inhalt der QuelleJorge Cáceres Salazar [Parte I], Patricio Carreño Acuña [Parte II]
Patricio Carreño Acuña [Parte II],no envía autorización para acceso a texto completo de su documento.
El presente trabajo consiste en el desarrollo de un plan de negocio para la empresa C&C Power Technologies, cuyo giro corresponde a la provisión de servicios energéticos con el objetivo de aumentar los niveles de eficiencia energética de sus clientes, esto en base a un modelo de negocio ESCO, cuya sigla en inglés significa Energy Services Company. Dentro de la industria de servicios energéticos, las empresas que operan bajo el modelo ESCO se caracterizan principalmente por dirigir íntegramente un proyecto de eficiencia energética en las instalaciones del cliente, incluyendo una auditoría energética, propuestas técnicas, propuestas de financiamiento, instalación y mantenimiento de equipamiento tecnológico y monitoreo de ahorros energéticos logrados. Este modelo de negocio se caracteriza por crear una relación a largo plazo con el cliente, donde los servicios son pagados durante años a través del ahorro monetario generado en base al mayor ahorro energético logrado en los procesos productivos de los clientes. Bajo este modelo de negocios, el cliente normalmente transfiere los riesgos técnicos y financieros a C&C Power Technologies. En relación al sector servicios energéticos a la cual pertenece C&C Power Technologies, este se encuentra inmersa en un contexto en donde los desafíos en el ámbito de la energía a nivel nacional son relevantes. A nivel país estamos frente a múltiples y complejos retos que exigen soluciones eficientes: el crecimiento en la demanda de energía, la dependencia energética, el cambio climático y la expansión del sistema eléctrico, entre otros. Frente a todos estos desafíos, la eficiencia energética surge como una solución factible y sustentable para nuestro país. Al respecto, muchas empresas han comenzado a responder a esta necesidad en dicho ámbito, es así como se ha ido consolidando la industria de servicios energéticos, cuyos esfuerzos se han orientado en alcanzar mayores niveles de eficiencia energética en los diversos rubros económicos. De esta forma, la eficiencia energética es parte de la solución, ya que disminuye el consumo de energía del país, reduce la dependencia de los energéticos importados, aumenta la seguridad de suministro y disminuye las emisiones de gases efecto invernadero. Adicionalmente, contribuye a incrementar la competitividad del país, al haber menores costos de producción. La idea de desarrollar este proyecto nace fundamentalmente como una respuesta a necesidades concretas al interior de las empresas, particularmente en relación al alza sostenido del precio de las distintas fuentes energéticas, lo cual incide directamente en la necesidad de las empresas para bajar sus costos productivos, así como también a la necesidad de lograr mayores niveles de responsabilidad social empresarial, mediante la menor emisión de elementos contaminantes hacia el medioambiente. Los servicios que C&C Power Technologies pretende comercializar en el mercado son: i) auditorías energéticas; ii) consultorías en eficiencia energética, e; iii) implementación de proyectos de eficiencia energética. El modelo de negocios que se quiere implementar en C&C Power Technologies va más allá de limitarse a entregar un diagnóstico energético a sus clientes tal como lo hace la mayor parte de las empresas consultoras en el ámbito de la eficiencia energética establecidas en el país. Este modelo ofrece soluciones prácticas y con un alto valor agregado dado que se ofrece llevar a cabo la dirección integra de proyectos de eficiencia energética, asegurando resultados en términos de ahorros energéticos a ser logrados. Es por esto que el modelo de negocios de C&C Power Technologies posee un mayor atractivo en relación a otros tipos de proyectos que en la actualidad se comercializan en el ámbito de la eficiencia energética, en donde la implementación y monitoreo de los resultados finalmente queda a cargo del cliente. Dentro del plan financiero, se da a conocer el VAN esperado de la empresa, el cual asciende a $418.820.330 (TIR 75,2%). Mediante una simulación de escenarios se demuestra un significativo nivel de sensibilidad del VAN sujeto al cambio en el número de servicios comercializados por la empresa durante los próximos diez años, lo cual da cuenta de que el negocio tiene un nivel de riesgo medio/alto.
Perry, Ian B. (Ian Brooks). „Transition metal-facilitated C-C and C-F bond forming“. Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/112449.
Der volle Inhalt der QuelleCataloged from PDF version of thesis. "June 2017."
Includes bibliographical references.
Chapter 1. Copper-Catalyzed Asymmetric Addition of Olefin-Derived Nucleophiles to Ketones A copper (I) catalyzed coupling olefins and ketones has been developed for the diastereo- and enantioselective generation of homopropargyl alcohols bearing vicinal stereocenters. This method allows for the generation of enantioenriched tertiary alcohols with a high degree of functional group compatibility. The utility of the process is further illustrated by a large scale synthesis with extremely low catalyst loading as well as the late stage modification of several pharmaceuticals. Chapter 2. Copper-Catalyzed Enantioselective Addition of Styrene-Derived Nucleophiles to Imines We describe the catalytic generation of amines bearing vicinal stereocenters with a moderate degree of diastereoselectivity. The stereoselective hydrocupration of an unactivated olefinic component is followed by nucleophilic addition of the organocuprate to an N-phosphinoyl protected imine. The mild and general process tolerates a broad-range of functionality, and the process was shown to be successful at a gram-scale synthesis. Chapter 3. Palladium-facilitated Regioselective Nucleophilic Fluorination of Aryl and Heteroaryl Halides. The preliminary findings regarding an aryl and heteroaryl halide fluorination process facilitated by palladium as a reagent is described. Stoichiometric studies illustrate the utility of the method in producing aryl fluorides with unprecedented regioselectivity, and preliminary studies into the fluorination of five- and six-membered heteroaryl bromides are described. Halogen atom substitution as a route to irreversible oxidative addition of aryl and heteroaryl halides is discussed. This strategy may serve to facilitate the fluorination of particularly problematic heteroaryl bromide and chloride substrates.
by Ian B. Perry.
S.B.
Zhao, Tony. „Synthesis of functionalized allylic, propargylic and allenylic compounds : Selective formation of C–B, C–C, C–CF3 and C-Si bonds“. Doctoral thesis, Stockholms universitet, Institutionen för organisk kemi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-116863.
Der volle Inhalt der QuelleAt the time of the doctoral defense, the following paper was unpublished and had a status as follows: Paper 1: Accepted.
Poater, Teixidor Albert. „Isomerism and C-H, C-C, O-O, C-O bond activation studies by transition metals“. Doctoral thesis, Universitat de Girona, 2006. http://hdl.handle.net/10803/7939.
Der volle Inhalt der QuelleThis thesis shows that the cooperation between experimental and theoretical groups gives as a result the achievement of aims impossible working independently. From DFT calculations inorganic and organometallic problems related to great biological and industrial processes can be explained. This thesis is especially focused on the study of mononuclear and binuclear copper complexes, where a C-H, C-C, and O-O bond activation takes place. The study of octahedral ruthenium complexes has allowed carrying out isomeric studies and the rationalization of spectroscopic properties. Furthermore, other little studies related to copper clusters, the Pawson-Khand reaction, Pt-Pt bond interaction in trimer platinum complexes, and isomerism of Ni and Pt complexes.
Grünberg, Matthias F. [Verfasser], und Lukas [Akademischer Betreuer] Gooßen. „Nachhaltige Konzepte zur C-C, C-N und C-S Bindungsknüpfung / Matthias Grünberg. Betreuer: Lukas Gooßen“. Kaiserslautern : Technische Universität Kaiserslautern, 2015. http://d-nb.info/1080521704/34.
Der volle Inhalt der QuelleWrigglesworth, Joseph W. „The development of new palladium(II) catalysed C-C, C-N and C-O bond formations“. Thesis, University of Bristol, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.601218.
Der volle Inhalt der QuelleLee, Kang-sang. „New Concepts and Catalysts for Enantioselective Synthesis of C-C, C-Si, and C-B Bonds“. Thesis, Boston College, 2010. http://hdl.handle.net/2345/1739.
Der volle Inhalt der QuelleChapter 1. The development of chiral monodentate N-heterocyclic carbenes (NHCs) is presented. Structurally varied twenty-eight new chiral imidazolinim salts, NHC precursors, were synthesized and characterized. Chapter 2. The first example of Cu-catalyzed enantioselective conjugate additions of alkyl- and arylzinc reagents to unactivated cyclic enones is presented. Transformations are promoted in the presence of 2.5-15 mol % of a readily available chiral NHC-based Cu complex, affording the desired products bearing all-carbon quaternary stereogenic centers in 67-98% yield and in up to 97% ee. Catalytic enantioselective reactions can be carried out on a benchtop, with undistilled solvent and commercially available (not further purified) Cu salts. Chapter 3. A new class of enantioselective conjugate addition (ECA) reactions that involve aryl- or alkenylsilylfluoride reagents and are catalyzed by chiral non-C2-symmetric Cu-based NHC complexes are presented. Transformations have been designed based on the principle that a catalytically active chiral NHC-Cu-aryl or NHC-Cu-alkenyl complex can be accessed from reaction of a Cu-halide precursor with in situ-generated aryl- or alkenyl-tetrafluorosilicate. Reactions proceed in the presence of 1.5 equivalents of the aryl- or alkenylsilane reagents and 1.5 equivalents of tris(dimethylamino)sulfonium difluorotrimethylsilicate. Desired products are isolated in 63-97% yield and 73.5:26.5-98.5:1.5 enantiomeric ratio (47%-97% ee). Chapter 4. An efficient Cu-catalyzed protocol for enantioselective addition of a dimethylphenylsilanyl group to a wide range of cyclic and acyclic unsaturated ketones, esters, acrylonitriles and dienones is presented. Reactions are performed in the presence of 1-5 mol % of commercially available and inexpensive CuCl, a readily accessible monodentate imidazolinium salt as well as commercially available (dimethylphenylsilyl)pinacolatoboron. Cu-catalyzed 1,4- and 1,6-conjugate additions afford the enantiomerically enriched silanes in 72%-98% yield and 90:10->99:1 enantiomeric ratio (er) with up to >25:1 of Z:E selectivity. Chapter 5. A Cu-catalyzed method for enantioselective boronate conjugate additions to trisubstituted alkenes of acyclic a,b-unsaturated carboxylic esters, ketones, and thioesters is presented. All transformations are promoted by 5 mol % of a chiral monodentate NHC-Cu complex, derived from a readily available C1-symmetric imidazolinium salt, and in the presence of commercially available bis(pinacolato)diboron. Reactions are efficient (typically, 60% to >98% yield after purification) and deliver the desired boryl carbonyls in up to >98:2 enantiomer ratio (er). In addition, metal-free, nucleophilic activation of a B-B bond has been exploited in the development of a highly efficient method for conjugate additions of commercially available bis(pinacolato)diboron to cyclic or acyclic a,b-unsaturated carbonyls. Reactions are readily catalyzed by 2.5-10 mol % of a simple NHC. A variety of cyclic and acyclic unsaturated ketones and esters can serve as substrates. Transformations deliver boryl carbonyls bearing tertiary as well as quaternary B-substituted carbons in up to >98% yield
Thesis (PhD) — Boston College, 2010
Submitted to: Boston College. Graduate School of Arts and Sciences
Discipline: Chemistry
Mudarra, Alonso Ángel Luis. „Coinage complexes in C-C and C-N bond-forming reactions“. Doctoral thesis, Universitat Rovira i Virgili, 2020. http://hdl.handle.net/10803/670357.
Der volle Inhalt der QuelleLos complejos organometálicos de cobre, plata y oro juegan un papel fundamental como especies reactivas en diversas transformaciones químicas. Esta tesis aporta conocimiento sobre el comportamiento de estos complejos en la formación de enlaces C-C y/o C-N. En concreto, estudiamos: i) el mecanismo de reacción por el cual complejos de cobre co-catalizan un acoplamiento oxidante en el contexto de sistemas bimetálicos de rodio y cobre; ii) el potencial de nucleófilos de plata como agentes transmetalantes en reacciones de trifluorometilación catalizadas por paladio; iii) el mecanismo de reacción de sistemas bimetálicos de Pd/Ag usando un sistema modelo; y iv) el comportamiento de complejos bis(trifluorometil) cuprato, argentato y aurato como nucleófilos. En esta tesis, donde se han combinado estudios experimentales y computacionales, se ha adquirido nuevo conocimiento sobre los procesos estudiados, y se ha contribuido al campo de la investigación química basada en el conocimiento.
Organometallic coinage metal complexes are be key reactive species for promoting a wide variety of chemical transformations. This thesis improves the understanding the behavior of these complexes in relevant C-C and/or C-N bond-forming reactions. Specifically, we have explored: i) the mechanistic intricacies of copper species as co-catalyst in the context of rhodium/copper-catalyzed oxidative coupling reactions; ii) the capability of silver nucleophiles as transmetalating agents in palladium-catalyzed trifluoromethylation reactions; iii) the reaction mechanism of Pd/Ag bimetallic reactions using a model system as probe; and, iv) the study of bis(trifluoromethyl) coinage metallates as nucleophiles. The fundamental insights gathered in this Thesis, encompassing both experimental and computational approaches, improve our understanding of the processes under study and make a contribution to the general field of knowledge-driven research in Chemistry.
Moselage, Marc Philipp. „C-H and C-C Activation by Cobalt and Ruthenium Catalysis“. Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2017. http://hdl.handle.net/11858/00-1735-0000-0023-3FB2-6.
Der volle Inhalt der QuelleKümpers, Britta Maren Charlotte. „Understanding C₄ leaf development using closely related C₃ & C₄ species“. Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709247.
Der volle Inhalt der QuelleKanuru, Vijaykumar. „Understanding surface mediated C-C and C-N bond forming reactions“. Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608956.
Der volle Inhalt der QuelleTruscott, Fiona Rosemary. „Transition metal catalysed C-C bond formation via C-H functionalisation“. Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:6a1ef296-8d63-470d-96bd-3e01a887c81f.
Der volle Inhalt der QuelleKorvorapun, Korkit. „Site-Selectivity in Ruthenium-Catalyzed C–H and C–C Activations“. Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2020. http://hdl.handle.net/21.11130/00-1735-0000-0005-148C-7.
Der volle Inhalt der QuelleMeggiato, Francesca <1989>. „catalisi micellare nella formazione di legami C-C e C-O“. Master's Degree Thesis, Università Ca' Foscari Venezia, 2017. http://hdl.handle.net/10579/10470.
Der volle Inhalt der QuelleRangatia, Janki. „C/EBPalpha downregualtes c-jun expression“. Diss., lmu, 2003. http://nbn-resolving.de/urn:nbn:de:bvb:19-10825.
Der volle Inhalt der QuelleThathagar, Mehul Bhupendra. „Nanocluster catalysed C-C coupling reactions“. [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2006. http://dare.uva.nl/document/18448.
Der volle Inhalt der QuelleOldland, John Rupert. „London clothmaking, c. 1270-c. 1550“. Thesis, Royal Holloway, University of London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406519.
Der volle Inhalt der QuelleAgee, Laura L. „Sun C to ANSI C converter /“. Master's thesis, This resource online, 1995. http://scholar.lib.vt.edu/theses/available/etd-10242009-020128/.
Der volle Inhalt der QuelleStadler, Daniel Eberhard. „Diastereoselektive SN1-artige C-C-Verknüpfungen“. München Verl. Dr. Hut, 2009. http://d-nb.info/993731287/04.
Der volle Inhalt der QuelleBollwein, Tobias. „Metallierung, oxidative C-C-Kupplung und C-N-Aktivierung mit Zinkorganyl-Verbindungen“. Diss., [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=963033077.
Der volle Inhalt der QuelleKulchat, Sirinan. „Dynamic covalent chemistry of C=N, C=C and quaternary ammonium constituents“. Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAF018/document.
Der volle Inhalt der QuelleThis thesis describes the dynamic covalent chemistry (DCC) of imine/imine, Knoevenagel/imine, and Knoevenagel/Knoevenagel exchange. L-proline is shown to be an excellent organocatalyst to accelerate the formation of dynamic covalent libraries (DCLs). The interconversion between Knoevenagel derivatives of dimethylbarbituric acid and imines is found to occur rapidly in the absence of catalyst. A new class of DCC based on nucleophilic substitution (SN2/SN2’) component exchange between quaternary ammonium salts and tertiary amines is developed, by the use of iodide as a catalyst. The exchange reactions between pyridinium salts and a pyridine derivative generate dynamic ionic liquids. Finally, kinetic and thermodynamic selection of imine formation in a DCC is perfomed in aqueous solution and organic solvent
Torkelson, Jeffrey Robert. „C-H bond activation and C-C bond formation at adjacent metals“. Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ34848.pdf.
Der volle Inhalt der QuelleCatino, Arthur John. „Oxidative C-H and C-C bond functionalization catalyzed by dirhodium caprolactamate“. College Park, Md. : University of Maryland, 2006. http://hdl.handle.net/1903/4188.
Der volle Inhalt der QuelleThesis research directed by: Chemistry. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
Wang, Hui. „Cobalt(III)- and Manganese(I)-Catalyzed C-H and C-C Activations“. Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2019. http://hdl.handle.net/11858/00-1735-0000-002E-E5EF-5.
Der volle Inhalt der QuelleDesmarchelier, Alaric. „Cascades réactionnelles organocatalysées : création stéréosélective de liaisons C-N et C-C“. Versailles-St Quentin en Yvelines, 2012. http://www.theses.fr/2012VERS0031.
Der volle Inhalt der QuelleThe work presented in this manuscript aims at the study of organocascade reactions enabling the stereoselective formation of C-N and C-C bonds. Several sequential one-pot approaches yielding highly functionalized products from simple substrates have been developed. The first chapter describes the enantioselective synthesis of aziridines from α-substituted enals. α-difunctionalization of aldehydes has then been studied via double-enamine activation. The second chapter presents a one-pot Mannich reaction/electrophilic amination of acetaldehyde, leading to vicinal diamines. The third chapter studies a Michael reaction/electrophilic amination cascade, giving rise to hydrazinoaldehydes bearing a quaternary stereocenter. Finally, the last chapter focuses on the electrophilic amination of α,α-disubstituted aldehydes, and its application in an organocascade reaction, leading to 3-pyrrolines with a quaternary stereocenter
Pardue, Daniel B. „Computational Studies of C–H/C–C Manipulation Utilizing Transition Metal Complexes“. Thesis, University of North Texas, 2015. https://digital.library.unt.edu/ark:/67531/metadc801892/.
Der volle Inhalt der QuelleWolfe, John P. (John Perry) 1970. „Late transition metal catalyzed C-N and C-C bond forming reactions“. Thesis, Massachusetts Institute of Technology, 1999. http://hdl.handle.net/1721.1/9521.
Der volle Inhalt der QuelleIncludes bibliographical references.
New methods for the palladium-catalyzed amination of aryl halides are described. Key to these is the development of new catalysts and reaction conditions for these transformations. Initially, P(o-tol)3 ligated palladium catalysts were investigated but gave way to systems that used chelating phosphine ligands which substantially expanded the scope of the catalytic amination methodology. Palladium catalyst systems based on BINAP ((2,2'-diphenylphosphino)-1, 1 '-binaphthyl) allowed for the transformation of a much wider range of amines and aryl halide substrates, as well as aryl triflates. Of practical significance was that the use of cesium carbonate as a base at 100 °C substantially increased the functional group tolerance of the method. Palladium catalysts supported by novel, bulky, electron-rich phosphine ligands are exceptionally effective in the C-N, C-0, and C-C coupling procedures. For some substrate combinations, these palladium catalysts are effective for the room-temperature catalytic amination of aryl chlorides. These palladium catalysts are also highly effective for Suzuki coupling reactions of aryl bromides and chlorides at room temperature. Suzuki coupling reactions of aryl bromides and aryl chlorides are effective at very low catalyst loadings (0.000001-0.005 mol % Pd for ArBr, 0.02-0.05 mol % for ArCI) at 100 °C, and reactions of hindered aryl halides or boronic acids are effected at moderate catalyst loadings (1 mol % Pd). The high reactivity of these catalysts towards aryl chlorides challenges the conventional dogma that chloride substrates cannot be transformed under mild conditions with palladium catalysts, and significantly expands the pool of substrates available for cross-coupling chemistry.
by John P. Wolfe.
Ph.D.
Midya, S. P. „Transition metal catalyzed (de) hydrogenative C-C and C-N bond formation“. Thesis(Ph.D.), CSIR-National Chemical laboratory, Pune, 2018. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/4568.
Der volle Inhalt der QuelleHachicha, Mohamed. „Regulation of C-C and C-X-C chemokine gene expression in synovial fibroblasts and peripheral blood neutrophils“. Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1996. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ25241.pdf.
Der volle Inhalt der QuelleChudasama, V. „The use of aerobic aldehyde C-H activation for the construction of C-C and C-N bonds“. Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1324525/.
Der volle Inhalt der QuelleStraccia, Marco. „C/EBPß and C/EBPß in neuroinflammation“. Doctoral thesis, Universitat Autònoma de Barcelona, 2012. http://hdl.handle.net/10803/96887.
Der volle Inhalt der QuelleNeuroimmunology studies the relationship between immune and nervous system. It originated in the last decade of the 19th century with Santiago Ramón y Cajal work, but only recently it has exploded as an active research topic. The increase incidence of neurological disorders, especially in high-income countries, has pointed out one of the main clinical aspects of neuroimmunology, the neuroinflammation. Abnormal endogenous and/or exogenous signals can cause neuroinflammation which represents a pleiotropic physiological response initiated by the central nervous system (CNS) innate immunity arm and sometimes mediated by the adaptive peripheral arm. Astrocytes and especially microglia are the immune cell effectors in the CNS. In the last decades many functions of glial cells have been shown, such as adult neurogenesis reservoir or constitutive players in neuronal synaptic transmission. However, one of the main glial roles is to maintain the homeostasis in the adult nervous system by supporting neuronal activity, regulating the microenvironment and buffering any disturbances. When CNS homeostasis is compromised over a physiological threshold, astrocytes and microglia undergo enormous phenotypical changes when attempting to reestablish the original environmental state. This process is known as glial activation. This thesis focuses on glial activation. Since glial activation is highly interconnected with several aspects of immune physiology of CNS, many features of nervous-immune system will be briefly introduced. Glial activation causes a marked change in glial cell physiology, resulting in a profound reorganization of transcriptional machinery and its fine regulation. So far, several transcription factors have been described to control glial activation during pro- and anti-inflammatory response. This thesis focus on the transcriptional regulation of pro-inflammatory glial activation and particularly the role of two members of Ccaat Enhancer Binding Protein family (C/EBPs), the transcription factors C/EBPβ and C/EBPδ. Through bioinformatic, biochemical and cell biology analyses we have characterized transcriptional targets of C/EBPβ and C/EBPδ during glial activation in vitro. In vitro mixed glial cultures and in vivo models of C/EBPs deficient mice have been used to demonstrate the key role of C/EBPβ and C/EBPβ in glial activation, especially in activated microglia. This thesis clearly demonstrates that C/EBPβ and C/EBPδ interact with key pro-inflammatory gene promoters and their absence reduces mRNA and protein levels of target genes in glial activation. In addition, it is shown that C/EBPβ and C/EBPδ control the neurotoxic potential of microglia in vitro. Gene expression analysis of systemically LPS-treated knockout mice has also shown an in vivo C/EBPs transcriptional role in brain cortex neuroinflammation. This work demonstrates for the first time the important role triggered by C/EBPβ and C/EBPδ in glial activation, highlighting these transcription factors as potential therapeutic targets to reduce the detrimental consequences of neuroinflammation.
Javanbakhti, Reza, und Jimmy Pesola. „Statisk detektering av minneshanteringsfel i C/C++“. Thesis, Karlstad University, Division for Information Technology, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-408.
Der volle Inhalt der QuelleDet här examensarbetet är baserat på idéer ur ett uppdrag från företaget Saab Aerotech men är ett eget arbete.
Målet var att undersöka om det finns behov av ett verktyg som statiskt kan detektera dynamiska minneshanteringsproblem, som till exempel minnesläckage, i applikationer skrivna i C/C++. På grund av att minneshanteringsfel i C/C++ länge har varit ett känt problem undersökte vi detta och de befintliga lösningarna till det.
Vi fann två metoder till lösningar som de flesta verktyg använde sig av; statisk och dynamisk detektering. De flesta verktyg löste problemet genom att dynamiskt detektera minnesläckor och andra brister som till exempel buffer overflows. Ett verktyg löste dock problemet genom att statisk detektera minneshanteringsfel i källkoden för applikationerna. Eftersom alla befintliga lösningar har någon form av ineffektivitet så har vi undersökt möjligheten att utveckla ett mer effektivt verktyg. Vi har kommit fram till att denna möjlighet finns men det kräver enormt mycket tid och arbete att göra ett komplett verktyg som detekterar minneshanteringsfel statiskt.
Vår prototyp detekterar dynamiska minneshanteringsproblem i källkoden statiskt. Vi har använt oss av hjälpverktygen Flex och Bison för att utveckla vår prototyp av verktyget. Prototypen kan analysera källkod skriven i programspråken C och C++ och klarar att detektera minnesläckage, felaktiga avallokeringar av minne, dangling pointers, samt läsning från och skrivning till ogiltiga minnesområden. På grund av tidsbrist har vi i nuläget inte implementerat något stöd för klasser och objekt i prototypen.
This bachelor’s project is our own project, but it is based on ideas from an assignment from the Saab Aerotech company.
The goal was to investigate if there is a need for a tool that statically can detect dynamic memory management errors, such as memory leaks, in applications written in C/C++. Since the problem of memory management errors in the C/C++ languages has been known for a long time, we decided to investigate this and the existing solutions.
We found that most tools used two methods as solutions; static and dynamic detection. Most of these tools solve the problem by dynamically detecting memory leaks and other deficiencies such as buffer overflows. However, one of these tools used static detection of these deficiencies by scanning the source code of the applications. Since all the existing solutions have some kind of inefficiency, we have investigated the possibility to develop a more efficient tool. We concluded that this is possible but it will take a lot of time and effort to implement a complete tool that statically detects memory management errors.
Our prototype statically detects dynamic memory management problems in the source code. We have used the tools Flex and Bison to develop our prototype of a static detection tool. The prototype analyzes source code written in the programming languages C and C++ and is capable of detecting memory leaks, invalid deallocations of memory, dangling pointers and reading from and writing to invalid memory areas. Currently, due to lack of time, we have not implemented any support for classes and objects in the prototype.
Brown, Anthony Joseph. „Anglo-Irish Gallicanism, c.1635 - c.1685“. Thesis, University of Cambridge, 2004. https://www.repository.cam.ac.uk/handle/1810/251908.
Der volle Inhalt der QuelleClark, Felicity Helen. „The Northumbrian Frontiers c.500 - c.850“. Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.519757.
Der volle Inhalt der QuelleBrown, Dearg Sutherland. „Anomeric C-C bond formation via sulphones“. Thesis, Imperial College London, 1991. http://hdl.handle.net/10044/1/46687.
Der volle Inhalt der QuelleWebster, Paul. „King John's piety, c.1199 - c.1216“. Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612999.
Der volle Inhalt der QuelleMarsland, Rebecca Louise Katherine. „Complaint in Scotland c.1424- c.1500“. Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:05468bd1-c936-426f-9ab4-79afb94a59fb.
Der volle Inhalt der QuelleEl, Ayoubi Rami. „Dérivés doublement liés de l'étain et de l'antimoine : stannènes, stannaallènes, stibènes et stibaallènes >Sn=C<, >Sn=C=C<, -Sb=C< et -Sb=C=C<“. Toulouse 3, 2008. http://thesesups.ups-tlse.fr/298/.
Der volle Inhalt der QuelleThis thesis describes the results obtained in the field of doubly-bonded derivatives of antimony -Sb=C<, -Sb=C=X (X = C, P) and tin >Sn=C<, >Sn=C=X (X = C, P). In the field of antimony, the synthesis of some precursors of such heteroallenes was described. A 1,3-distibacyclobutane, potential precursor of a stibene -Sb=C<, has been characterized. The attempts to obtain stibaallenes and phosphastibaallenes showed that a very large steric hindrance was necessary on antimony and carbon. In the field of tin, the new stable stannene Tip2Sn=CR2 was obtained and stabilized owing to a very large steric hindrance both on Sn and C. This stannene which appeared a true heteroallene according to NMR and X-ray data, was extremely reactive, particularly towards carbonyl compounds and dienes. Some precursors of stannaallenes >Sn=C=C< and phosphastannaallenes -P=C=Sn< have been prepared. A distannirane, obtained by reaction between the stannaallene Tip2Sn=C=CR2 and the stannylene Tip2Sn, was isolated
Lee, Alison Victoria. „Catalyst and methodology development for regioselective C-N and C-C bond formation“. Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/31377.
Der volle Inhalt der QuelleScience, Faculty of
Chemistry, Department of
Graduate
Fleser, Angelica. „Resténose et expression des proto-oncogènes, c-myc, c-fos et c-jun“. Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ35590.pdf.
Der volle Inhalt der QuelleGraczyk, Karolina. „Iron- and Ruthenium-Catalyzed Site-Selective C–C Forming Direct C–H Functionalizations“. Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2015. http://hdl.handle.net/11858/00-1735-0000-0022-5FA5-4.
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