Zeitschriftenartikel: „Boron-neutron capture therapy“

1

Taskaev, S. Yu. „Boron Neutron Capture Therapy“. Physics of Atomic Nuclei 84, Nr. 2 (März 2021): 207–11. http://dx.doi.org/10.1134/s106377882101021x.

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2

ONO, Koji, Minoru SUZUKI, Shinichiro MASUNAGA, Natsuko KONDO, Yoshinori SAKURAI, Hiroki TANAKA, Yuko KINASHI und Akira MARUHASHI. „Boron Neutron Capture Therapy“. RADIOISOTOPES 61, Nr. 4 (2012): 209–22. http://dx.doi.org/10.3769/radioisotopes.61.209.

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3

FREEMANTLE, MICHAEL. „BORON NEUTRON CAPTURE THERAPY“. Chemical & Engineering News 80, Nr. 34 (26.08.2002): 13. http://dx.doi.org/10.1021/cen-v080n034.p013.

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4

Beddoe, A. H. „Boron neutron capture therapy.“ British Journal of Radiology 70, Nr. 835 (Juli 1997): 665–67. http://dx.doi.org/10.1259/bjr.70.835.9245876.

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5

Slatkin, Daniel N. „Boron neutron-capture therapy“. Neutron News 1, Nr. 4 (Januar 1990): 25–28. http://dx.doi.org/10.1080/10448639008229357.

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6

Ota, Ichiro, und Tadashi Kitahara. „Boron Neutron Capture Therapy (BNCT)“. Practica Oto-Rhino-Laryngologica 107, Nr. 12 (2014): 937–46. http://dx.doi.org/10.5631/jibirin.107.937.

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7

&NA;. „Improving boron neutron capture therapy“. Inpharma Weekly &NA;, Nr. 971 (Januar 1995): 8. http://dx.doi.org/10.2165/00128413-199509710-00016.

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8

Mumot, M. „325. Boron Neutron Capture Therapy“. Reports of Practical Oncology & Radiotherapy 8 (2003): S354—S355. http://dx.doi.org/10.1016/s1507-1367(03)70808-6.

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9

Kato, I. „S17.1 Boron neutron capture therapy“. Oral Oncology Supplement 1, Nr. 1 (Januar 2005): 63. http://dx.doi.org/10.1016/s1744-7895(05)80118-x.

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10

Monti, V., M. Costa, E. Durisi, E. Mafucci, A. Calamida, A. I. Castro Campoy, A. Fontanilla, L. Russo und R. Bedogni. „Neutron spectroscopy for Boron Neutron Capture Therapy beams characterization“. Journal of Instrumentation 19, Nr. 05 (01.05.2024): C05036. http://dx.doi.org/10.1088/1748-0221/19/05/c05036.

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Abstract Boron Neutron Capture Therapy (BNCT) is a therapeutic treatment for malignant tumors that utilizes the nuclear reactions that happen when thermal neutrons are captured by boron-10 atoms to selectively destroy designated cells. Boron-10 atoms are biochemically accumulated inside the tumor target, which is then irradiated with thermal neutrons. In recent years, the possibility to obtain accelerator based intense neutron beams has given a boost to the diffusion of BNCT also in Europe, removing the need of nuclear reactors. In this contest, the monitoring and characterization of the epithermal neutron beams dedicated to BNCT becomes an important issue. The directional neutron spectrometer called NCT-WES (Neutron Capture Therapy Wide Energy Spectrometer) is a single moderator neutron spectrometer composed of a polyethylene cylinder embedding six semiconductor-based detectors positioned at different depths along the cylinder axes. The position of the six detectors is studied in order to maximize the response of each one in a selected neutron energy range. The unfolding of the six simultaneous readings allows to reconstruct the incoming neutron energy spectrum as in a parallelized Bonner Sphere System. A cylindrical collimator situated in the front of the spectrometer makes the instrument sensitive to neutrons coming only from a given direction, which allows to exclude the contribution of the room scattered radiation. The experimental validation of the spectrometer, obtained through several measuring campaigns, is reported and discussed.

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Sauerwein, Wolfgang A. G., Lucie Sancey, Evamarie Hey-Hawkins, Martin Kellert, Luigi Panza, Daniela Imperio, Marcin Balcerzyk et al. „Theranostics in Boron Neutron Capture Therapy“. Life 11, Nr. 4 (10.04.2021): 330. http://dx.doi.org/10.3390/life11040330.

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Boron neutron capture therapy (BNCT) has the potential to specifically destroy tumor cells without damaging the tissues infiltrated by the tumor. BNCT is a binary treatment method based on the combination of two agents that have no effect when applied individually: 10B and thermal neutrons. Exclusively, the combination of both produces an effect, whose extent depends on the amount of 10B in the tumor but also on the organs at risk. It is not yet possible to determine the 10B concentration in a specific tissue using non-invasive methods. At present, it is only possible to measure the 10B concentration in blood and to estimate the boron concentration in tissues based on the assumption that there is a fixed uptake of 10B from the blood into tissues. On this imprecise assumption, BNCT can hardly be developed further. A therapeutic approach, combining the boron carrier for therapeutic purposes with an imaging tool, might allow us to determine the 10B concentration in a specific tissue using a non-invasive method. This review provides an overview of the current clinical protocols and preclinical experiments and results on how innovative drug development for boron delivery systems can also incorporate concurrent imaging. The last section focuses on the importance of proteomics for further optimization of BNCT, a highly precise and personalized therapeutic approach.

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12

Edgecock, Rob. „Accelerator-driven boron neutron capture therapy“. International Journal of Modern Physics A 29, Nr. 14 (26.05.2014): 1441004. http://dx.doi.org/10.1142/s0217751x14410048.

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Boron Neutron Capture Therapy is a binary treatment for certain types of cancer. It works by loading the cancerous cells with a boron-10 carrying compound. This isotope has a large cross-section for thermal neutrons, the reaction producing a lithium nucleus and alpha particle that kill the cell in which they are produced. Recent studies of the boron carrier compound indicate that the uptake process works best in particularly aggressive cancers. Most studied is glioblastoma multiforme and a trial using a combination of BNCT and X-ray radiotherapy has shown an increase of nearly a factor of two in mean survival over the state of the art. However, the main technical problem with BNCT remains producing a sufficient flux of neutrons for a reasonable treatment duration in a hospital environment. This paper discusses this issue.

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13

Wuu, C. S., H. I. Amols, P. Kliauga, L. E. Reinstein und S. Saraf. „Microdosimetry for Boron Neutron Capture Therapy“. Radiation Research 130, Nr. 3 (Juni 1992): 355. http://dx.doi.org/10.2307/3578381.

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14

Barth, Rolf F., Albert H. Soloway und Ralph G. Fairchild. „Boron Neutron Capture Therapy for Cancer“. Scientific American 263, Nr. 4 (Oktober 1990): 100–107. http://dx.doi.org/10.1038/scientificamerican1090-100.

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15

Sauerwein, Wolfgang. „81 Boron neutron capture therapy (BNCT)“. Radiotherapy and Oncology 40 (Januar 1996): S23. http://dx.doi.org/10.1016/s0167-8140(96)80088-0.

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16

Barth, Rolf F., und Albert H. Soloway. „Perspective on boron neutron capture therapy“. International Journal of Radiation Oncology*Biology*Physics 28, Nr. 5 (März 1994): 1059–60. http://dx.doi.org/10.1016/0360-3016(94)90478-2.

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17

Yamamoto, Tetsuya, Kei Nakai und Akira Matsumura. „Boron neutron capture therapy for glioblastoma“. Cancer Letters 262, Nr. 2 (April 2008): 143–52. http://dx.doi.org/10.1016/j.canlet.2008.01.021.

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18

Hatanaka, H. „Boron neutron capture therapy for tumors“. International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes 37, Nr. 1 (Januar 1986): 79–80. http://dx.doi.org/10.1016/0883-2889(86)90215-7.

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19

Hu, Kuan, Zhimin Yang, Lingling Zhang, Lin Xie, Lu Wang, Hao Xu, Lee Josephson, Steven H. Liang und Ming-Rong Zhang. „Boron agents for neutron capture therapy“. Coordination Chemistry Reviews 405 (Februar 2020): 213139. http://dx.doi.org/10.1016/j.ccr.2019.213139.

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20

Salt, C., A. J. Lennox, M. Takagaki, J. A. Maguire und N. S. Hosmane. „Boron and gadolinium neutron capture therapy“. Russian Chemical Bulletin 53, Nr. 9 (September 2004): 1871–88. http://dx.doi.org/10.1007/s11172-005-0045-6.

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21

Howard, William Bruce. „Accelerator-based boron neutron capture therapy“. Medical Physics 25, Nr. 6 (Juni 1998): 1060. http://dx.doi.org/10.1118/1.598286.

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22

MORRIS, J. H. „ChemInform Abstract: Boron Neutron Capture Therapy“. ChemInform 22, Nr. 32 (22.08.2010): no. http://dx.doi.org/10.1002/chin.199132313.

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23

Metwally, Walid A., Yumna A. Alharahsheh, Entesar Z. Dalah und Husam Al-Omari. „Utilizing neutron generators in boron neutron capture therapy“. Applied Radiation and Isotopes 174 (August 2021): 109742. http://dx.doi.org/10.1016/j.apradiso.2021.109742.

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24

Wolber, Gerd. „Fast Neutron Beams for Boron Neutron Capture Therapy?“ Zeitschrift für Medizinische Physik 14, Nr. 1 (2004): 55–63. http://dx.doi.org/10.1078/0939-3889-00192.

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25

Conte, Valeria, Anna Bianchi und Anna Selva. „Boron Neutron Capture Therapy: Microdosimetry at Different Boron Concentrations“. Applied Sciences 14, Nr. 1 (26.12.2023): 216. http://dx.doi.org/10.3390/app14010216.

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This paper explores the role of microdosimetry in boron neutron capture therapy (BNCT), a cancer treatment involving the selective accumulation of boron-containing compounds in cancer cells, followed by neutron irradiation. Neutron interactions with 10B induces a nuclear reaction, releasing densely ionizing particles, specifically alpha particles and recoiling lithium-7 nuclei. These particles deposit their energy within a small tissue volume, potentially targeting cancer cells while sparing healthy tissue. The microscopic energy distribution, subject to significant fluctuations due to the short particle range, influences treatment efficacy. Microdosimetry, by studying this distribution, plays a crucial role in optimizing BNCT treatment planning. The methodology employs paired tissue equivalent proportional counters (TEPCs), one with cathode walls enriched with boron and the other without. Precise assessment of boron concentration is essential, as well as the ability to extrapolate results to the actual 10B concentration within the treatment region. The effective 10B concentrations within four boronated TEPCs, containing 10, 25, 70, and 100 ppm of 10B, have been determined. Results show variations of less than 3% from nominal values. Additionally, dose enhancement due to BNC interactions was measured and found to be proportional to the 10B concentration, with a proportionality factor of 7.7 × 10−3 per ppm of boron. Based on these findings, a robust procedure is presented for assessing the impact of BNCT in the treatment region, considering potential variations in boron content relative to the TEPC used.

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Ogura, K., A. Yamazaki, H. Yanagie, M. Eriguchi, E. H. Lehmann, G. Küehne, G. Bayon, K. Maruyama und H. Kobayashi. „Neutron capture autoradiography for a study on boron neutron capture therapy“. Radiation Measurements 34, Nr. 1-6 (Juni 2001): 555–58. http://dx.doi.org/10.1016/s1350-4487(01)00227-x.

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27

Takahashi, Minoru, Tooru Kobayashi, Mingguang Zhang, Michael Mak, Jiri Stefanica, Vaclav Dostal und Wei Zhao. „ICONE19-43192 STUDY ON HIGH SPEED LITHIUM JET FOR NEUTRON SOURCE OF BORON NEUTRON CAPTURE THERAPY (BNCT)“. Proceedings of the International Conference on Nuclear Engineering (ICONE) 2011.19 (2011): _ICONE1943. http://dx.doi.org/10.1299/jsmeicone.2011.19._icone1943_74.

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28

Ailuno, Giorgia, Alice Balboni, Gabriele Caviglioli, Francesco Lai, Federica Barbieri, Irene Dellacasagrande, Tullio Florio und Sara Baldassari. „Boron Vehiculating Nanosystems for Neutron Capture Therapy in Cancer Treatment“. Cells 11, Nr. 24 (13.12.2022): 4029. http://dx.doi.org/10.3390/cells11244029.

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Boron neutron capture therapy is a low-invasive cancer therapy based on the neutron fission process that occurs upon thermal neutron irradiation of 10B-containing compounds; this process causes the release of alpha particles that selectively damage cancer cells. Although several clinical studies involving mercaptoundecahydro-closo-dodecaborate and the boronophenylalanine–fructose complex are currently ongoing, the success of this promising anticancer therapy is hampered by the lack of appropriate drug delivery systems to selectively carry therapeutic concentrations of boron atoms to cancer tissues, allowing prolonged boron retention therein and avoiding the damage of healthy tissues. To achieve these goals, numerous research groups have explored the possibility to formulate nanoparticulate systems for boron delivery. In this review. we report the newest developments on boron vehiculating drug delivery systems based on nanoparticles, distinguished on the basis of the type of carrier used, with a specific focus on the formulation aspects.

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Sumitani, Shogo, und Yukio Nagasaki. „Boron neutron capture therapy assisted by boron-conjugated nanoparticles“. Polymer Journal 44, Nr. 6 (04.04.2012): 522–30. http://dx.doi.org/10.1038/pj.2012.30.

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30

Pitto-Barry, Anaïs. „Polymers and boron neutron capture therapy (BNCT): a potent combination“. Polymer Chemistry 12, Nr. 14 (2021): 2035–44. http://dx.doi.org/10.1039/d0py01392g.

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31

Susilowati, Anggraeni Dwi, Kusminarto Kusminarto und Yohannes Sardjono. „Boron Neutron Capture Therapy (BNCT) using Compact Neutron generator“. Indonesian Journal of Physics and Nuclear Applications 1, Nr. 2 (30.06.2016): 73. http://dx.doi.org/10.24246/ijpna.v1i2.73-80.

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Boron Neutron Capture Therapy (BNCT) must be appropriate with ﬁve criteria from IAEA. These criteria in order to prevent neutron beam output harm the patient. It can be by using Collimator of neutron source Compact Neutron Generator (CNG) and Monte Carlo simulation method with N particles 5 .CNG is developed by deuteriumtritium reaction (DT) and deuterium-deuterium (DD) reaction. The manufacture result of the collimator is obtained epithermal neutron ﬂux value of 1.69e-9 n/cm^2s for D-T reaction and 8e6 n/cm^2s for D-D reaction, ratio of epithermal and thermal is 1.95e-13 Gy cm^2/n for D-T reaction and for D-D reaction, ratio of fast neutron component is 1.69e-13 Gy cm^2/n for D-T reaction and for D-D reaction, ratio of gamma component is 1.18e-13 Gy cm^2/nfor D-T reaction and for D-D reaction. The Latest reaction is current ratio 0.649 for D-T reaction and 0.46 for D-D reaction.

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32

Kiyanagi, Yoshiaki. „Accelerator-based neutron source for boron neutron capture therapy“. Therapeutic Radiology and Oncology 2 (November 2018): 55. http://dx.doi.org/10.21037/tro.2018.10.05.

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33

Perks, C. A., und J. A. B. Gibson. „Neutron Spectrometry and Dosimetry for Boron Neutron Capture Therapy“. Radiation Protection Dosimetry 44, Nr. 1-4 (01.11.1992): 425–28. http://dx.doi.org/10.1093/oxfordjournals.rpd.a081477.

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34

Perks, C. A., und J. A. B. Gibson. „Neutron Spectrometry and Dosimetry for Boron Neutron Capture Therapy“. Radiation Protection Dosimetry 44, Nr. 1-4 (01.11.1992): 425–28. http://dx.doi.org/10.1093/rpd/44.1-4.425.

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35

Kasatov, D., A. Koshkarev, A. Kuznetsov, A. Makarov, Yu Ostreinov, I. Shchudlo, I. Sorokin, T. Sycheva, S. Taskaev und L. Zaidi. „The accelerator neutron source for boron neutron capture therapy“. Journal of Physics: Conference Series 769 (November 2016): 012064. http://dx.doi.org/10.1088/1742-6596/769/1/012064.

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36

Zaidi, L., E. A. Kashaeva, S. I. Lezhnin, G. N. Malyshkin, S. I. Samarin, T. V. Sycheva, S. Yu Taskaev und S. A. Frolov. „Neutron-beam-shaping assembly for boron neutron-capture therapy“. Physics of Atomic Nuclei 80, Nr. 1 (Januar 2017): 60–66. http://dx.doi.org/10.1134/s106377881701015x.

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37

Golubev, S. V., I. V. Izotov, S. V. Razin, A. V. Sidorov und V. A. Skalyga. „A Compact Neutron Source for Boron Neutron Capture Therapy“. Radiophysics and Quantum Electronics 59, Nr. 8-9 (Januar 2017): 682–89. http://dx.doi.org/10.1007/s11141-017-9735-9.

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38

Kim, Woohyoung, Ji Yeong Won, Jungyu Yi, Seung Chan Choi, Sang Min Lee, Kyungran Mun und Hyeong-Seok Lim. „PK Modeling of L-4-Boronophenylalanine and Development of Bayesian Predictive Platform for L-4-Boronophenylalanine PKs for Boron Neutron Capture Therapy“. Pharmaceuticals 17, Nr. 3 (26.02.2024): 301. http://dx.doi.org/10.3390/ph17030301.

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L-4-[(10B)]Boronophenylalanine (BPA) is an amino acid analogue with a boron-10 moiety. It is most widely used as a boron carrier in boron neutron capture therapy. In this study, a Bayesian predictive platform of blood boron concentration based on a BPA pharmacokinetic (PK) model was developed. This platform is user-friendly and can predict the individual boron PK and optimal time window for boron neutron capture therapy in a simple way. The present study aimed to establish a PK model of L-4-boronophenylalanine and develop a Bayesian predictive platform for blood boron PKs for user-friendly estimation of boron concentration during neutron irradiation of neutron capture therapy. Whole blood boron concentrations from seven previous reports were graphically extracted and analyzed using the nonlinear mixed-effects modeling (NONMEM) approach. Model robustness was assessed using nonparametric bootstrap and visual predictive check approaches. The visual predictive check indicated that the final PK model is able to adequately predict observed concentrations. The Shiny package was used to input real-time blood boron concentration data, and during the following irradiation session blood boron was estimated with an acceptably short calculation time for the determination of irradiation time. Finally, a user-friendly Bayesian estimation platform for BPA PKs was developed to optimize individualized therapy for patients undergoing BNCT.

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Minoru, SUZUKI. „New Application for Boron Neutron Capture Therapy“. RADIOISOTOPES 64, Nr. 1 (2015): 59–66. http://dx.doi.org/10.3769/radioisotopes.64.59.

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40

Maulana, Indra. „ANIMATION OF BORON NEUTRON CAPTURE CANCER THERAPY“. Indonesian Journal of Physics and Nuclear Applications 3, Nr. 3 (22.12.2018): 102–12. http://dx.doi.org/10.24246/ijpna.v3i3.102-112.

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One of the most common causes of death in the world is cancer. Scientists have been trying to find the best cure for cancer ever since it was discovered. There are some ways that are used to treat cancer patients. Lately, scientists have developed a new way in treating cancer, it’s called Boron Neutron Capture Therapy (BNCT). BNCT is a selective cancer therapy, it only selects the cancer cells to be treated and leaves the normal cell untouched. It may have no effect or only a little effect on normal cells. As new knowledge that needs to be known by all people, what is the best way to introduce BNCT? What is the best media to introduce BNCT? Is it enough to just read it in a newspaper or in a book? How about using advanced technology such as animation to introduce BNCT? The use of animation as a form of media to introduce something new is already being done in many fields. Can animation be used as a form of media to introduce BNCT too? Will it be effective? By this study, the author gives information about the effect of using animation as a tool to explain and understand BNCT more.

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41

Kanygin, V. V., E. L. Zavyalov, A. E. Simonovich, A. I. Kichigin, A. I. Kasatova, R. A. Mukhamadiyarov, R. V. Sibirtsev, N. S. Filin und T. V. Sycheva. „BORON NEUTRON CAPTURE THERAPY OF GLIAL TUMORS“. Современные проблемы науки и образования (Modern Problems of Science and Education), Nr. 3 2019 (2019): 144. http://dx.doi.org/10.17513/spno.28914.

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42

Akan, Zafer. „Boron Neutron Capture Therapy for Breast Cancer“. International Journal of Women's Health and Reproduction Sciences 3, Nr. 2 (07.02.2015): 77. http://dx.doi.org/10.15296/ijwhr.2015.14.

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43

Carlsson, Jorgen, Stefan Sjoberg und Bengt S. Larsson. „Present Status of Boron Neutron Capture Therapy“. Acta Oncologica 31, Nr. 8 (Januar 1992): 803–13. http://dx.doi.org/10.3109/02841869209089712.

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44

Kabalka, George W. „Recent developments in boron neutron capture therapy“. Expert Opinion on Therapeutic Patents 8, Nr. 5 (Mai 1998): 545–51. http://dx.doi.org/10.1517/13543776.8.5.545.

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45

Raaijmakers, C. P. J., E. L. Nottelman, B. J. Mijnheer und E. L. Nottelman. „Phantom materials for boron neutron capture therapy“. Physics in Medicine and Biology 45, Nr. 8 (25.07.2000): 2353–61. http://dx.doi.org/10.1088/0031-9155/45/8/320.

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46

Walker, Simon J. „Boron neutron capture therapy: principles and prospects“. Radiography 4, Nr. 3 (August 1998): 211–19. http://dx.doi.org/10.1016/s1078-8174(98)80048-5.

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47

Carlsson, Jörgen, Erika Bohl Kullberg, Jacek Capala, Stefan Sjöberg, Katarina Edwards und Lars Gedda. „Ligand liposomes and boron neutron capture therapy“. Journal of Neuro-oncology 62, Nr. 1-2 (März 2003): 47–59. http://dx.doi.org/10.1007/bf02699933.

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48

Gupta, Nilendu, Reinhard A. Gahbauer, Thomas E. Blue und André Wambersie. „Dose prescription in boron neutron capture therapy“. International Journal of Radiation Oncology*Biology*Physics 28, Nr. 5 (März 1994): 1157–66. http://dx.doi.org/10.1016/0360-3016(94)90490-1.

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49

Diaz, Aidnag Z., Jeffrey A. Coderre, Arjun D. Chanana und Ruimei Ma. „Boron neutron capture therapy for malignant gliomas“. Annals of Medicine 32, Nr. 1 (Januar 2000): 81–85. http://dx.doi.org/10.3109/07853890008995913.

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50

Rij, Catharina M. van, Abraham J. Wilhelm, Wolfgang A. G. Sauerwein und Arie C. van Loenen. „Boron neutron capture therapy for glioblastoma multiforme“. Pharmacy World & Science 27, Nr. 2 (April 2005): 92–95. http://dx.doi.org/10.1007/s11096-004-2850-7.

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