Thematische Bibliographien / Biomoleculaire

Inhaltsverzeichnis

  1. Zeitschriftenartikel
  2. Dissertationen
  3. Bücher
  4. Buchteile
  5. Konferenzberichte
  6. Berichte der Organisationen

Auswahl der wissenschaftlichen Literatur zum Thema „Biomoleculaire“

Autor: Grafiati
Veröffentlicht am 21. Dezember 2024

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Zeitschriftenartikel zum Thema "Biomoleculaire"

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Tongzhou Wang, Tongzhou Wang, Liping Xie Liping Xie, Haley Huang Haley Huang, Xin Li Xin Li, Ruliang Wang Ruliang Wang, Guang Yang Guang Yang, Yanan Du Yanan Du und Guoliang Huang Guoliang Huang. „Label-free biomolecular imaging using scanning spectral interferometry“. Chinese Optics Letters 11, Nr. 11 (2013): 111102–5. http://dx.doi.org/10.3788/col201311.111102.

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Sainz de Murieta, Inaki, Jesus M. Miro-Bueno und Alfonso Rodriguez-Paton. „Biomolecular Computers“. Current Bioinformatics 6, Nr. 2 (01.06.2011): 173–84. http://dx.doi.org/10.2174/1574893611106020173.

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OZAWA, Takeaki. „Biomolecular Science“. TRENDS IN THE SCIENCES 16, Nr. 5 (2011): 53–57. http://dx.doi.org/10.5363/tits.16.5_53.

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DOI, Junta. „Biomolecular Visualization“. Journal of the Visualization Society of Japan 10, Nr. 39 (1990): 222–27. http://dx.doi.org/10.3154/jvs.10.222.

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Hulme, John P., Jihye Gwak und Yuji Miyahara. „Biomolecular Embossing“. Journal of the American Chemical Society 128, Nr. 2 (Januar 2006): 390–91. http://dx.doi.org/10.1021/ja055805r.

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Brown, Keri A., und Terence A. Brown. „Biomolecular Archaeology“. Annual Review of Anthropology 42, Nr. 1 (21.10.2013): 159–74. http://dx.doi.org/10.1146/annurev-anthro-092412-155455.

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HILGARTNER, STEPHEN. „Biomolecular Databases“. Science Communication 17, Nr. 2 (Dezember 1995): 240–63. http://dx.doi.org/10.1177/1075547095017002009.

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Hemaspaandra, Lane A. „Biomolecular computing“. ACM SIGACT News 30, Nr. 2 (Juni 1999): 22–30. http://dx.doi.org/10.1145/568547.568557.

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Hess, Henry, und George D. Bachand. „Biomolecular motors“. Materials Today 8, Nr. 12 (Dezember 2005): 22–29. http://dx.doi.org/10.1016/s1369-7021(05)71286-4.

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Koehler, M., und S. Diekmann. „Biomolecular nanotechnology“. Reviews in Molecular Biotechnology 82, Nr. 1 (November 2001): 1–2. http://dx.doi.org/10.1016/s1389-0352(01)00031-9.

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Dissertationen zum Thema "Biomoleculaire"

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Corsaro, Daniele. „Infections par des micro-organismes intracellulaires : approche biomoleculaire du diagnostic et de l'epidemiologie (doctorat : genie biologique et medical)“. Nancy 1, 2000. http://www.theses.fr/2000NAN11321.

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Navarrete, Belda Vanessa. „Domesticación animal y primeras prácticas ganaderas en el noreste peninsular (5500-4500 cal BC). Integración de los análisis bioquímicos en arqueozoología“. Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/461194.

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En el presente trabajo de tesis doctoral se aborda la problemática de la dinámica del proceso de domesticación animal y las prácticas ganaderas iniciales en el extremo más occidental del área mediterránea a lo largo del intervalo temporal que abarca entre el 5.500-4.700 cal ANE. El objetivo principal de la tesis se aborda a partir del estudio de una muestra significativa de yacimientos neolíticos situados en el noreste de la Península Ibérica. Se ha evaluado con esta tesis doctoral los principales modelos explicativos planteados en torno a los orígenes del neolítico en la Península Ibérica, prestando especial atención a las hipótesis y explicaciones formuladas sobre el proceso de domesticación animal y practicas ganaderas iniciales. A partir de los nuevos datos aportados con el estudio de una muestra significativa de yacimientos neolíticos del área del noreste peninsular se ha analizado la información existente bajo el prisma de la tafonomía, demostrando la importancia de considerar no solo la composición de los conjuntos de restos de fauna, sino su grado de representatividad histórica. La contextualización de los nuevos datos obtenidos a nivel peninsular y europeo, con un énfasis especial en el área mediterránea, ha aportado documentos significativos sobre las implicaciones que tuvieron la adopción y cría de rebaños de las cuatro principales especies domésticas. Los análisis efectuados han permitido constatar la explotación polivalente de los diferentes tipos de producciones animales, la plena integración de los ciclos agrícola y ganaderos, la práctica de estrategias ganaderas tanto intensivas como extensivas y la existencia de explotaciones ganaderas permanentes en zonas elevadas del Pirineo durante el Neolítico Inicial, documentos todo ellos que obligan a replantear algunas de las asunciones que han guiado hasta la actualidad el debate sobre los orígenes del Neolítico. A nivel metodológico, el método seguido contempla como novedad de manera integrada los procesos analíticos desarrollados en el marco de la disciplina arqueológica, arqueotafonómica, arqueozoológica y biomolecular. Esta aproximación ha permitido documentar, caracterizar y evaluar los procesos de trabajo vinculados a la explotación y gestión de los animales domésticos durante el Neolítico Inicial. La integración de los análisis de isotopos estables ha supuesto una aportación significativa al estudio de la gestión ganadera, y ha permitido caracterizar las estrategias implementadas en la alimentación de los primeros animales domésticos. Los resultados ponen en evidencia la rápida adaptación de los animales domésticos a los ambientes peninsulares, documentándose la practica una estrategia ganadera plenamente consolidada caracterizada por la posibilidad de modelar la estructura demográfica de los rebaños, la productividad de las especies y las capacidades de adaptación alimentaria de los animales dependiendo de características fisiológicas y etológicas de cada especie. La interpretación de los resultados muestra que la adopción de las técnicas ganaderas no es un proceso lineal ni homogéneo a inicios del Neolítico en la Península Ibérica. La documentación de modalidades regionales pone en relieve la importancia y magnitud del estudio de la domesticación animal y practicas ganaderas iniciales en el marco del proceso de neolitización en esta área geográfica.
In the present doctoral PhD thesis the problematic of the dynamics of the process of animal domestication and the initial husbandry practices in the most western part of the Mediterranean area throughout the temporal interval that covers between 5,500-4,700 cal ANE is addressed. The main objective of this research is approached from the study of a significant sample of Neolithic sites located in the northeast of the Iberian Peninsula. The main explanatory models proposed about the origins of the Neolithic in the Iberian Peninsula have been evaluated with this doctoral thesis, focusing on the hypotheses and explanations formulated about the process of animal domestication and initial livestock practices. Based on the new data provided by the study of a significant sample of Neolithic sites in the northeastern peninsular area, the existing information has been analyzed from a taphonomical perspective, pointing out the importance of considering not only the composition of the faunal remains, but also its degree of historical representativeness. The contextualisation of the new data obtained at peninsular and European level, with a special emphasis on the Mediterranean area, has provided significant documents of the implications of adoption and herding of the four main domestic species. The analyzes carried out have shown polyvalent exploitation of the different types of animal production, full integration of the agricultural and livestock cycles, practice of intensive and extensive livestock strategies and existence of permanent livestock farms in the high areas of the Pyrenees during the Early Neolithic. All these documents force us to rethink some of the assumptions that have guided the debate on the origins of agriculture and pastoralism. At a methodological level, it is to be note as a novelty that the method implemented integrated several analytical processes developed within the framework of archaeological, archaeo-taphonomical, archaeozoological and biomolecular disciplines. This approach has allowed to document, characterize and evaluate the work processes linked to the exploitation and management of domestic animals during the Early Neolithic period. The integration of stable isotope analysis has involved contributing in a significant manner to the study of livestock management, allowing to characterize the strategies implemented in the feeding of the first domestic animals. Results show the rapid adaptation of domestic animals to peninsular environments. Indeed, the practice of a fully consolidated livestock strategy characterized by the possibility of modeling the demographic structure of the herds, the productivity of the species and the food adaptation capacities of the animals depending on physiological and ethological characteristics of each species, has been documented. Therefore, results allow to interpret that the adoption of livestock techniques was a non-linear, non-homogenous process at the beginning of the Neolithic in the Iberian Peninsula. The documentation of regional modalities highlights the importance and magnitude of the study of animal domestication and initial livestock practices in the framework of the neolithization process in this geographical area.
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Giro, Vocel Alexia. „Prise en charge des cancers du sein : qualité de vie et caractérisations biomoléculaires de ces cancers“. Electronic Thesis or Diss., Université Clermont Auvergne (2021-...), 2024. http://www.theses.fr/2024UCFA0096.

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Le cancer du sein est le plus fréquent chez la femme en France, représentant 33% des cas, suivi par le cancer colorectal et celui du poumon. Il est également le plus meurtrier, étant responsable de 18% des décès féminin par cancer.Mes travaux de thèse visent à améliorer la prise en charge des patientes atteintes d'un cancer du sein. Pour cela, il est essentiel de prendre en compte leur qualité de vie ainsi que les caractéristiques biomoléculaires de leur tumeur. J'ai ainsi structuré mes travaux de thèse autour de ces deux axes.Concernant la qualité de vie des patientes, je suis en charge de l'analyse finale et de la valorisation de l'étude MENOCOR qui étudie l'impact de la ménopause chimio-induite (MCI) chez les femmes jeunes en âge de procréer. Dans ce manuscrit, je vous présente les premiers résultats de l'étude (impact de la MCI sur le score fonctionnel du QLQ-C30 ainsi que sur les hormones). Les patientes sont réparties en 2 groupes à la fin de l'étude selon leur statut ménopausique : ménopausées et non ménopausées. Les résultats montrent une tendance indiquant que l'évolution du score dans le temps entre les 2 groupes est différente : les patientes ménopausées voient leur qualité de vie diminuer dans le temps contrairement aux patientes non ménopausées (p=0.058). Les 2 groupes diffèrent selon l'âge (p<0,001) et les récepteurs aux œstrogènes (p=0,03). L'hormone anti-müllérienne (AMH), dont la différence entre les 2 groupes est significative à l'inclusion (p<0,001), se révèle être un marqueur utile dans la définition du statut ménopausique des patientes. Les résultats finaux permettront d'avoir des données concernant la ménopause (incidence, facteurs de risque) ainsi que son impact sur la qualité de vie afin de permettre, dans l'avenir, d'adapter la prise en charge des patientes jeunes et ménopausées de manière précoce.Je me suis également consacrée à la conception du projet AR-GBS visant à mettre au point une technique de réalité augmentée pour le repérage préopératoire des lésions infracliniques du cancer du sein. La technique de réalité augmentée qui sera développée à l'issue de cette étude permettra aux patientes de ne pas avoir recours aux techniques de repérages actuelles invasives et donc d'améliorer leur prise en charge chirurgicale et par conséquent leur qualité de vie.La caractérisation biomoléculaire des tumeurs est investiguée dans l'étude PERCEPTION qui s'intéresse à la corrélation entre les éléments figurés du sang et l'infiltration lymphocytaire tumorale chez les femmes atteintes d'un cancer du sein triple négatif. Je me suis occupée de la gestion de l'étude, de l'analyse intermédiaire ainsi que de sa valorisation. Les résultats obtenus n'ont pas permis de mettre en évidence de corrélation entre le Neutrophil-to-Lymphocyte Ratio (NLR) et le pourcentage de lymphocytes infiltrant la tumeur (TILs) (rs = -0.19, IC 95% [-0.49 ; 0.16], p = 0.3). Contrairement aux attentes basées sur la littérature existante, les résultats montrent une tendance à une corrélation positive entre le NLR et le ratio des TILs CD8/FoxP3 (rs = 0.36, IC 95% [0.03 ; 0.64], p = 0.043). En raison de la fiable taille de l'échantillon et du manque de puissance statistique, l'absence de différence observée doit être interprétée avec prudence. Il est donc nécessaire d'attendre les résultats de l'analyse finale pour conclure. Cette analyse intermédiaire a également permis d'identifier certains éléments à optimiser pour l'analyse finale telle que la méthode utilisée pour déterminer le nombre de TILs de chaque sous-population qui n'est pas suffisamment représentative de l'infiltration réelle.Ces travaux offrent ainsi des perspectives prometteuses pour améliorer la prise en charge et la qualité de vie des patientes atteintes d'un cancer du sein. La poursuite de ces études permettra non seulement de confirmer les tendances observées mais aussi d'affiner les stratégies thérapeutiques adaptées aux besoins spécifiques des patientes
Breast cancer is the most common cancer among women in France, accounting for 33% of cases, followed by colorectal and lung cancers. It is also the deadliest, responsible for 18% of female cancer deaths.My doctoral research aims to improve the management of patients with breast cancer. To achieve this, it is crucial to consider both their quality of life and the biomolecular characteristics of their tumors. I have structured my thesis work around these two themes.Regarding the quality of life of patients, I am responsible for the final analysis and publication of the MENOCOR study, which examines the impact of chemotherapy-induced menopause (CIM) in young women of childbearing age. In this manuscript, I present the initial results of the study (the impact of CIM on the functional score of the QLQ-C30 and hormone levels). At the end of the study, the patients are divided into two groups based on their menopausal status: menopausal and non-menopausal. The results indicate a trend suggesting that the evolution of the score over time differs between the two groups: menopausal patients experience a decrease in quality of life over time, unlike non-menopausal patients (p = 0.058). The two groups differ in terms of age (p < 0.001) and estrogen receptors (p = 0.03). The Anti-Müllerian Hormone (AMH), which shows a significant difference between the two groups at baseline (p < 0.001), proves to be a useful marker in defining the menopausal status of patients. The final results will provide data on menopause (incidence, risk factors) and its impact on quality of life, enabling the adaptation of early management for young and menopausal patients in the future.I also took part of the AR-GBS project conception, which aims to develop an augmented reality technique for the preoperative localization of subclinical breast cancer lesions. The augmented reality technique developed as a result of this study will allow patients to avoid current invasive localization techniques, thereby improving their surgical management and, consequently, their quality of life.The biomolecular characterization of tumors is investigated in the PERCEPTION study, which explores the correlation between blood components and tumor infiltration lymphocytes in women with triple-negative breast cancer. I was responsible for managing the study, conducting the interim analysis, and its publication. The results did not demonstrate a correlation between the Neutrophil-to-Lymphocyte Ratio (NLR) and the percentage of tumor-infiltrating lymphocytes (TILs) (rs = -0.19, 95% CI [-0.49; 0.16], p = 0.3). Contrary to expectations based on existing literature, the results show a trend toward a positive correlation between the NLR and the CD8/FoxP3 TIL ratio (rs = 0.36, 95% CI [0.03; 0.64], p = 0.043). Due to the small sample size and lack of statistical power, the absence of an observed difference should be interpreted with caution. Therefore, it is necessary to await the final analysis results to draw conclusions. This interim analysis also identified areas for optimization in the final analysis, such as the method used to determine the number of TILs in each subpopulation, which is not sufficiently representative of the actual infiltration.These works thus offer promising perspectives for improving the management and quality of life of breast cancer patients. Continuing these studies will not only confirm the observed trends but also refine therapeutic strategies tailored to the specific needs of patients
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Portugal, Rodrigo Villares. „Estudos de complexos macromoleculares por crio-microscopia eletrônica e técnicas biofísicas“. Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-14112014-104525/.

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Este trabalho apresenta o estudo e caracterização de dois complexos moleculares, hRXRálfadeltaAB e hemocianina de Acanthoscurria gomesiana, através de técnicas estruturais e biofísicas. O uso da técnica de crio-microscopia eletrônica para o estudo da hemocianina de Acanthoscurria gomesiana, resultou em um modelo estrutural com resolução de 14 angstron- pelo métodode Fourier Shell Correlation com critério de 1/2 bit. Neste limite de resolução, já é possível observar detalhes estruturais que o mostram como sendo comptível com outros modelos de hemocianinas. Com relação ao estudo de hRXRalfadeltaAB, mostrou-se, através das técnicas de cromatografia analítica de exclusão por tamanho, eletroforese de gel de poliacrilamida e SAXS, que a proteína pode se apresentar no estado dimérico em solução, mesmo na ausência do seu ligante, 9-cis-RA. Também foi estudado a associação de hRXRalfadeltaAB a elementos responsivos: DR1, DR4, F2 e PAL. Suas constantes de dissociação foram calculadas através da técnica de espectroscopia por anisotropia de fluorescência. Os resultados obtidos mostram maior afinidade por DR1 e DR2 e indicam uma origem entrópica para o processo de associação
This work describes characterization of two biomolecular complexes: hRXR deltaAB and a hemocyanin from Acanthoscurria gomesiana using structural and biophysical techniques. Application of cryo-electron microscopy to studies of a hemocyanin from Acanthoscurria gomesiana resulted in its structural model to 14Å resolution, which was calculated by Fourier Shell Correlation with cut-off of 1/2 bit. At this resolution limit one can observe structural details of the complex which are compatible with other hemocyanin models. With respect to hRXR deltaAB, we showed using analytic size exclusion chromatography, SDS PAGE and SAXS, that the protein is dimeric in solution even at the absence of its ligand, 9-cis-RA. hRXR deltaAB binding to the responsive elements of DNA, DR1, DR4, F2 and PAL was investigated and the binding constants to these responsive elements have been determined using fluorescence anisotropy technique. Our results show higher affinity of the receptor to DR1 and DR4 and indicate entropic mechanism of DNA binding
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Cunha, João Victor de Souza. „Aplicação de Monte Carlo para a geração de ensembles e análise termodinâmica da interação biomolecular“. Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-25112016-143220/.

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As interações moleculares, em especial as de caráter não-covalente, são processos-chave em vários aspectos da biologia celular e molecular, desde a comunicação entre as células ou da velocidade e especificidade das reações enzimáticas. Portanto, há a necessidade de estudar e criar métodos preditivos para calcular a afinidade entre moléculas nos processos de interação, os quais encontram uma gama de aplicações, incluindo a descoberta de novos fármacos. No geral, entre esses valores de afinidade, o mais importante é a energia livre de ligação, que normalmente é determinada por modos computacionalmente rápidos, porém sem uma forte base teórica, ou por cálculos muito complexos, utilizando dinâmica molecular, onde mesmo com um grande poder de determinação da afinidade, é muito custoso computacionalmente. O objetivo deste trabalho é avaliar um modelo menos custoso computacionalmente e que promova um aprofundamento na avaliação de resultados obtidos a partir de simulações de docking molecular. Para esta finalidade, o método de Monte Carlo é empregado para a amostragem de orientações e conformações do ligante do sítio ativo macromolecular. A avaliação desta metodologia demonstrou que é possível calcular grandezas entrópicas e entálpicas e analisar a capacidade interativa entre complexos proteína-ligante de forma satisfatória para o complexo lisozima do bacteriófago T4.
The molecular interactions, especially the ones with a non-covalent nature, are key processes in general aspects of cellular and molecular biology, including cellular communication and velocity and specificity of enzymatic reactions. So, there is a strong need for studies and development of methods for the calculation of the affinity on interaction processes, since these have a wide range of applications like rational drug design. The free energy of binding is the most important measure among the affinity measurements. It can be calculated by quick computational means, but lacking on strong theoretical basis or by complex calculations using molecular dynamics, where one can compute accurate results but at the price of an increased computer power. The aim of this project is to evaluate a computationally inexpensive model which can improve the results from molecular docking simulations. For this end, the Monte Carlo method is implemented to sample different ligand configurations inside the macromolecular binding site. The evaluation of this methodology showed that is possible to calculate entropy and enthalpy, along analyzing the interactive capacity between receptor-ligands complexes in a satisfactory way for the bacteriophage T4.
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Coltro, Wendell Karlos Tomazelli. „Detecção condutométrica sem contato: uma nova ferramenta para monitoramento de interações biomoleculares em microssistemas analíticos“. Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/75/75132/tde-21082009-100220/.

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O trabalho descrito nesta tese mostra a aplicação de um sistema de detecção condutométrica sem contato acoplado capacitivamente (C4D) para monitorar interações biomoleculares em microssistemas analíticos. Inicialmente, o desempenho analítico de microssistemas fabricados em vidro, poli(dimetilsiloxano) (PDMS) e poliéster-toner (PT) foi avaliado de modo a escolher o melhor material (em termos de facilidades de fabricação, custo e repetibilidade) para os ensaios biomoleculares. Dentre os materiais estudados, os dispositivos fabricados em PT mostraram-se mais adequados para testes rápidos, onde a repetibilidade analítica não é o parâmetro mais importante. Os dispositivos fabricados em PDMS e selados contra uma placa de vidro apresentaram os melhores resultados em termos de repetibilidade e o desempenho analítico foi similar aos dispositivos de vidro. Dessa maneira, os dispositivos fabricados em PDMS/vidro foram escolhidos para a demonstração dos objetivos da tese. Por outro lado, os dispositivos fabricados em PT foram explorados para estudar a configuração geométrica do sistema de C4D. A instrumentação para monitoramento dos ensaios de ligação foi composta basicamente de dois sistemas de C4D, um software escrito em LabVIEW e um sistema de bombeamento das soluções. De modo a encontrar a configuração ideal da cela de detecção, geometrias contendo três, quatro e cinco eletrodos foram avaliadas em dispositivos de PT. A configuração ótima foi composta de três eletrodos, espaçados simetricamente. Nesta geometria, um eletrodo é utilizado para aplicar o sinal senoidal de excitação e os outros dois são utilizados para capturar o sinal resultante. As dimensões dos eletrodos (largura e espaçamento entre eles) foram otimizados usando ferramentas quimométricas. O complexo avidina-biotina foi utilizado como modelo de ligação para mostrar a aplicabilidade do sistema proposto. Para os microssistemas biomoleculares, os eletrodos (com geometria otimizada) foram fabricados sobre a superfície de uma placa de vidro por fotolitografia, sputtering e lift-off. Os eletrodos de detecção foram isolados com uma camada de óxido de silício com espessura de 50 nm, depositada pelo processo de deposição química em fase de vapor assistida por plasma. A camada de SiO2 foi modificada quimicamente com solução de 3-amino-propil-trietóxi-silano em etanol. Para imobilização covalente de biotina, uma alíquota de 10 ?L de fotobiotina dissolvida em água (0,1 mg/mL) foi adicionada à superfície e exposta a radiação ultravioleta (365 nm, 10 mW/cm2) durante 15 min. A detecção foi realizada aplicando um sinal senoidal, a partir de um gerador de funções, ao eletrodo de excitação registrando o sinal resultante nos dois eletrodos receptores. Para minimizar a captura de ruído elétrico, os experimentos foram realizados em uma gaiola de Faraday. O controle e a aquisição de dados foi feito mediante um software escrito em LabVIEW monitorando os sensorgramas de condutividade em tempo real. Os canais microfluídicos foram fabricados em PDMS por litografia suave e selados irrevesivelmente contra a placa de vidro contendo os eletrodos isolados e modificados quimicamente. As soluções (tampão e amostra) foram manuseadas com auxílio de uma bomba peristáltica ou duas bombas seringas. Soluções contendo tampão e avidina foram introduzidas nos microcanais e as mudanças de conductividade foram monitoradas em função do tempo. As soluções contendo avidina permaneceram em contato com a superfície modificada até o sinal de condutividade atingir um patamar de equilíbrio. Depois disso, solução tampão foi introduzida no microcanal para remover os analitos adsorvidos à superfície. Duas válvulas solenóides foram utilizadas para permitir um controle automático da distribuição das soluções nos microcanais. O limite de detecção obtido para a interação entre avidina e biotina foi de 75 nmol L-1.
The study reported in this thesis shows the application of a capacitively coupled contactless conductivity detection (C4D) for monitoring biomolecular interactions on analytical microsystems. Initially, the analytical performance of the microsystems fabricated in glass, poly(dimethylsiloxane) (PDMS) and polyester-toner (PT) was investigated in order to choose the best material (in terms of fabrication facilities, costs and repeatability) for the biomolecular assays. Among all substrate materials studied, devices fabricated in PT showed suitability for quick experiments, in which the analytical repeatability is not the most important parameter. The devices fabricated in PDMS and sealed against a glass plate presented the best results in terms of repeatability and the analytical performance was similar to that one of glass devices. For this reason, PDMS/glass devices were chosen for showing the goals of this thesis. On the other hand, PT devices were employed to study the geometrical design of the C4D system. The instrumentation for monitoring binding assays was basically composed of two C4D systems, a software written in LabVIEW and a solution pumping system. In order to find the suitable detection cell configuration for this dual-C4D system, designs containing three, four and five electrodes were evaluated on PT devices. The optimal design was composed of three electrodes symmetrically spaced. In this configuration, one electrode is used for applying an excitation sinusoidal wave and the other two for picking up the resulting signal. The dimensions of the electrodes (width and gap) were optimized by chemometric tools. The avidin-biotin complex was used as a binding model for showing the feasibility of the proposed system. For the biomolecular microsystems, electrodes were fabricated on glass surface using photolithographic, sputtering and lift-off processes. Detection electrodes were insulated with a 50-nm silicon oxide layer deposited by plasmaenhanced chemical vapor deposition. The SiO2 layer was functionalized by immersing the cleaned surface in a 3-aminopropyltriethoxy-silane solution in ethanol for 3 h. For biotinylation of the amino-silane layer, 10 ?L of photobiotin dissolved in deionized water (0.1 mg/mL) was dropped on the modified glass surface and exposed to a 365 nm UV radiation at intensity of 10 mW/cm2 for 15 min. Detection was carried out by passing a sinusoidal excitation signal from the function signal generator to the first electrode and picking up the resulting signal at the two receiver electrodes. To reduce electrical noise pickup, all measurements were carried out in a Faraday cage. The data acquisition was obtained in a software written in LabVIEW and the conductivity sensorgrams were recorded in real-time. The microfluidic network was fabricated in PDMS by soft lithography and irreversibly sealed against the electrodes plate. Solutions were handled into microfluidic channels using a peristaltic pump or two syringe pumps. Buffer and avidin-containing solution was injected into the microchannels and conductivity changes were monitored over time. Avidin solutions were allowed to remain in contact with the surface until a stable conductivity had reached equilibrium. Avidin-free buffer solutions were then injected to rinse off non-specifically bound analytes. Two solenoid valves were used to allow an automatic dispensing of the sample/buffer solution into microchannels. The limit of detection found for avidin-biotin system was 75 nmol L-1.
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Hansel, Fabricio Augusto. „Arqueologia biomolecular“. Florianópolis, SC, 2004. http://repositorio.ufsc.br/xmlui/handle/123456789/87960.

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Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas. Programa de Pós-graduação em Química
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O presente trabalho analisou materiais provenientes de sítios arqueológicos da população pré-colonial Jê (ca. 1000 AD), localizados na faixa costeira de Santa Catarina. O objetivo principal do trabalho foi identificar a origem dos resíduos orgânicos preservados nos fragmentos de cerâmica escavados dos sítios pré-coloniais Jê, através das seguintes técnicas hifenadas: GC-MS, HT GC-MS e GC-C-MS IR. Foram analisados 118 fragmentos de cerâmica, sendo que 53 % dos fragmentos continham lipídios. A maioria classificada como gordura degradada de origem animal, sendo, embora em menor número, detectado resíduos de origem vegetal. A interpretação destes resíduos de origem animal foi realizado a partir da comparação com amostras de referencia arqueológicas (valores de d13C para colágenos de ossos) e modernas (distribuição dos ácidos graxos saturados em gordura de capivara, mamíferos aquáticos, bivalves e peixes,), pela identificação de novos biomarcadores (ácidos 4,8,12-trimetil-tridecanóico, pristânico, fitânico, C16, C18 e C20 w-(o-alquil-fenil)alcanóicos e di-hidroxiácidos) e através dos valores de d13C dos ácidos graxos Ac14:0, Ac16:0 e Ac18:0. Através destes foi possível comprovar que grande parte dos lipídios tinha sua origem em gorduras marinhas. Já a identificação dos resíduos de origem vegetal foi evidenciada através de triterpenos e ésteres de ceras epicuticulares.
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Defaus, Fornaguera Sira. „Glycoprobes for capture and identification of lectins from biological sources“. Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/277290.

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Glycosylation is a posttranslational modification affecting the fast majority of cellular surfaces through glycolipids and glycoproteins. It has been estimated that over 80% of all proteins are glycosylated and that the glycans decorating the periphery of these molecules are fundamental for the biological function of the entity. Many of these functions have yet to be unraveled. As the modification is a secondary-gene event, it depends on the availability and activity of a set of glycosyltransferases, the availability of both donor and acceptor substrate (both in time and place), as well as many other factors that may include temperature, pH, etc. As a consequence a single glycosylation site may express a certain number of different glycans, i.e., structural microheterogeneity. The importance of glycosylation as primary mediators of cellular communication, protein-protein cross-talk, and even cell-pathogen interaction has been attributed precisely to this phenomenon. In the past few years substantial advancements have been made in the understanding of the function of particular glycosidic epitopes, such as the most relevant blood group antigens ABO, and Sda, (sialyl)Lewisx,y,a,b, the HNK-1 antigen, etc., but many more structures have been identified without an attributed functionality, either as a stand-alone epitope or in conjunction with the underlying peptide structure. Similarly, a serious lack of knowledge still exists on the carbohydrate recognizing molecules, i.e. lectins and their function; even so they have been recognized over the last decades as decisive players in numerous biological processes, ranging from cell-cell communication, fertilization, pathogen-cell adhesion to metastasis. Both deficiencies are directly related to the absence of proper tools to elaborate well-defined carbohydrate epitopes for the study of their interaction characteristics and their employment in the discovery of new complementary molecules. Consequently, there is an increasing interest in finding powerful and nanosized tools to screen for these molecules and to study their carbohydrate interactions in detail. In this Thesis, two complementary approaches are described to characterize lectin-carbohydrate interactions with high sensitivity, low sample consumption, and without the need for sample labeling: SPR and CREDEX-MS. In SPR, we have developed an approach where the sugar is immobilized onto a sensor surface through a tailor-made peptide module that allows (1) to capture the lectin, (2) to characterize the interaction through kinetic and thermodynamic parameters, and (3) to identify the interacted protein by mass spectrometry. In CREDEX-MS, based on proteolytic excision of protein-carbohydrate complexes and mass spectrometric analysis, the peptides conforming the carbohydrate binding domain are identified. After completing a preliminary phase where the above mentioned methodologies are optimized and used for the study of carbohydrate-protein interactions using purified well-known lectins; the established platforms are employed to analyze carbohydrate-driven interactions in more complex systems. Specifically, SPR and CREDEX-MS techniques are applied in a research project on molecular aspects of reproduction with the main objective of disclosing the molecular elements that participate in the first steps of fertilization in bovine species, namely: formation of the sperm reservoir in the oviductal epithelium and gamete recognition (oocyte (ZP)-sperm interaction).
La glicosilació, el procés enzimàtic que uneix sacàrids per produir glicans que s'adhereixen a proteïnes, lípids o altres molècules biològiques, és una modificació co-traduccional i post-traduccional present a la pràctica totalitat de components cel•lulars, on trobem glicoproteïnes, glicolípids i altres glicoderivats. Pel que fa específicament a les proteïnes, s’estima que més d’un 80% estan glicosilades i que aquests glicans són fonamentals en processos biològics com la senyalització cel•lular, el cicle infecciós de certs patògens, les respostes inflamatòria i immune, la fertilització, etc. En els últims anys s’ha avançat substancialment en el coneixement bàsic de la funció de determinats epítops o cadenes glicosídiques concretes. No obstant, es desconeixen les funcions de moltes altres estructures glicosídiques. D’altra banda, també existeix un cert desconeixement sobre les molècules que reconeixen els carbohidrats, les lectines “lectores del codi glicòmic”. Aquestes proteïnes es caracteritzen per reconèixer i unir-se de forma reversible i específica a certs monosacàrids o epítops oligosacàrids donant lloc a interaccions similars a les reaccions antigen-anticòs o enzim-substrat. El paper de les lectines en processos com l'aglutinació i la definició de grups sanguinis, la inflamació (selectines), la mielinització del teixit nerviós, la progressió tumoral, etc., demostra la ubiqüitat i diversitat d'activitats en què es veuen implicades aquestes proteïnes. Per això, disposar d'una eina ràpida i fiable per al seu aïllament i identificació, previ a l'estudi de les seves interaccions amb polisacàrids, constitueix un objectiu de màxim interès en l'actual investigació biomèdica. En la present Tesi Doctoral, es descriuen dues aproximacions complementàries mitjançant les quals es poden caracteritzar les interaccions lectina-carbohidrat amb gran sensibilitat, poca mostra i sense la necessitat de cap marcatge. En la tècnica de ressonància de plasmó superficial (SPR), el sucre és immobilitzat sobre una superfície a través d'un mòdul peptídic, la qual cosa permet (1) capturar la lectina, (2) caracteritzar la seva interacció mitjançant paràmetres cinètics i termodinàmics i (3) identificar posteriorment la proteïna mitjançant espectrometria de masses. Complementàriament, la tècnica CREDEX-MS, basada en l'excisió proteolítica del complex proteïna-sucre i posterior anàlisi per espectrometria de masses, ens permet identificar els pèptids que formen part del domini d'unió al sucre.
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Haag, Nicole. „Probing biomolecular fragmentation“. Doctoral thesis, Stockholms universitet, Fysikum, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-54524.

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This thesis deals with fragmentation of complex molecular ions, especially biomolecules, in gas phase collision experiments. The aim is to investigate the relations between energy deposition and fragmentation and to shed light on the mechanisms behind energy and charge transfer processes in collisions involving the building blocks of life. Further, the question how a solvent environment influences the dissociation behavior is elucidated. In the first part of the thesis, results from different collision experiments with biomolecular ions are presented, focusing on electron capture induced dissociation of hydrated nucleotides and small peptides. The investigated processes may be relevant for the understanding of radiation damage and the optimization of sequencing methods used in protein research. Our results clearly demonstrate that effects due to surrounding solvent molecules are substantial. While the dissipation of internal energy by evaporation of the loosely bound solvent molecules may protect the biomolecule, the influence which this environment has on the electronic structure may lead to an enhancement or suppression of certain dissociation channels. The second part of the thesis focuses on recent instrumental developments. Here, the aim was to optimize and complement the techniques used in the experiments above and to have versatile tools available for different kinds of gas phase collision studies involving complex molecular ions. Therefore, we have constructed an electrospray ion source platform for the preparation of intense beams, with options of accumulation and cooling of mass selected ions, allowing for a large variety of experiments. This device is also intended to serve as an ion source for the new storage ring facility DESIREE (DoubleElectroStatic Ion Ring ExpEriment), which is currently under construction at Stockholm University. In these unique storage rings, oppositely charged ions may interact at very low relative velocities in a cryogenically cooled and ultrahigh vacuum environment.
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Bredenberg, Johan. „Modelling biomolecular interactions /“. Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-571-9.

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Bücher zum Thema "Biomoleculaire"

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Barrick, Douglas E. Biomolecular Thermodynamics. Boca Raton : Taylor & Francis, 2017. | Series: Foundations of biochemistry and biophysics: CRC Press, 2017. http://dx.doi.org/10.1201/9781315380193.

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Monticelli, Luca, und Emppu Salonen, Hrsg. Biomolecular Simulations. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-017-5.

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Kim, Jungbae, Seong H. Kim und Ping Wang, Hrsg. Biomolecular Catalysis. Washington, DC: American Chemical Society, 2008. http://dx.doi.org/10.1021/bk-2008-0986.

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Bagshaw, Clive R. Biomolecular Kinetics. Boca Raton : Taylor & Francis/CRC Press, 2017. | Series: Foundations of biochemistry and biophysics |: CRC Press, 2017. http://dx.doi.org/10.1201/9781315120355.

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Brown, Terry, und Keri Brown. Biomolecular Archaeology. Oxford, UK: Wiley-Blackwell, 2011. http://dx.doi.org/10.1002/9781444392449.

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Vsevolodov, Nikolai. Biomolecular Electronics. Herausgegeben von David Amiel. Boston, MA: Birkhäuser Boston, 1998. http://dx.doi.org/10.1007/978-1-4612-2442-6.

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Bonomi, Massimiliano, und Carlo Camilloni, Hrsg. Biomolecular Simulations. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9608-7.

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Fernández Stigliano, Ariel. Biomolecular Interfaces. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-16850-0.

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Rupp, Bernhard. Biomolecular crystallography. New York, NY: Garland Science, 2010.

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Rupp, Bernhard. Biomolecular crystallography. New York, NY: Garland Science, 2010.

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Buchteile zum Thema "Biomoleculaire"

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Du, Ke-Lin, und M. N. S. Swamy. „Biomolecular Computing“. In Search and Optimization by Metaheuristics, 265–81. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-41192-7_16.

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Solov’yov, Ilia A., Andrey V. Korol und Andrey V. Solov’yov. „Biomolecular Systems“. In Multiscale Modeling of Complex Molecular Structure and Dynamics with MBN Explorer, 171–98. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-56087-8_5.

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Dragoman, Daniela, und Mircea Dragoman. „Biomolecular Machines“. In Bionanoelectronics, 173–88. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-25572-4_6.

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Dragoman, Daniela, und Mircea Dragoman. „Biomolecular Computing“. In Bionanoelectronics, 189–206. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-25572-4_7.

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Schmidt, Jacob, und Carlo Montemagno. „Biomolecular Motors“. In Introduction to Nanoscale Science and Technology, 549–74. Boston, MA: Springer US, 2004. http://dx.doi.org/10.1007/1-4020-7757-2_23.

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Goncharova, Larisa, Yuri Melnikov und Alexander O. Tarakanov. „Biomolecular Immunocomputing“. In Lecture Notes in Computer Science, 102–10. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-540-45192-1_10.

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Carbajo, Rodrigo J., und José L. Neira. „Biomolecular NMR“. In SpringerBriefs in Biochemistry and Molecular Biology, 83–115. Dordrecht: Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-6976-2_4.

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Kheyraddini Mousavi, Arash, Zayd Chad Leseman, Manuel L. B. Palacio, Bharat Bhushan, Scott R. Schricker, Vishnu-Baba Sundaresan, Stephen Andrew Sarles et al. „Biomolecular Mechanics“. In Encyclopedia of Nanotechnology, 320. Dordrecht: Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-90-481-9751-4_100075.

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Aizawa, Masuo, So-ichi Yabuki und Hiroaki Shinohara. „Biomolecular Interface“. In Molecular Electronics, 269–75. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4615-7482-8_28.

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Ashrafuzzaman, Mohammad. „Biomolecular Machines“. In Introduction to Modern Biophysics, 133–67. New York: CRC Press, 2023. http://dx.doi.org/10.1201/9781003287780-6.

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Konferenzberichte zum Thema "Biomoleculaire"

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Reis, Gabriele Pereira dos, Diego Bezerra Soares, Isabela Reis Manzoli und Lohraine Talia Domingues. „MECANISMOS BIOMOLECULARES DA SUCCINILCOLINA NA HIPERTERMIA MALIGNA“. In II Congresso Brasileiro de Biologia Molecular On-line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/2326.

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Introdução: A Hipertermia Maligna (HM) é uma doença farmacogenética potencialmente grave, latente e de herança autossômica dominante caracterizada pelo excesso de resposta hipermetabólica durante exposição ao anestésico inalatório ou a um determinado relaxante muscular como a succinilcolina. Essa fisiopatologia desencadeia quadros de acidose metabólica, alterações cardiovasculares, rigidez muscular, falência renal e destruição completa do músculo estriado esquelético. Objetivos: Devido à alta letalidade dessa doença, bem como sua susceptibilidade em todos os grupos étnicos e em ambos os sexos, faz-se necessário mais estudos que elucidam o papel dos mecanismos clínicos e biomoleculares envolvidos no surgimento da HM. Sob esse viés, foi levantado o seguinte questionamento: “Quais os aspectos fisiopatológicos e biomoleculares da succinilcolina na Hipertermia Maligna?”. Material e Métodos: A pesquisa consiste em uma revisão de literatura com o intuito de esclarecer o papel da succinilcolina nos mecanismos que desencadeiam a hipertermia maligna. Para tanto, utilizou-se as bases de dados SciELO, PubMed e MedLine e a literatura Biologia Molecular Básica, do Zaha 5ª edição. Resultados: A partir dos estudos, foi possível observar que os mecanismos moleculares causam a potencialização do efluxo de cálcio do retículo sarcoplasmático do músculo esquelético em indivíduos susceptíveis, após a indução por anestésicos ou relaxantes musculares. Diante disso, há um acúmulo de cálcio no mioplasma que, por sua vez, irá ocasionar uma contínua contração muscular, fato que corrobora a diminuição de ATP e um processo de rigidez muscular e todos os sinais e sintomas associados à doença. Tendo em vista que a succinilcolina é um relaxante muscular despolarizante, ela se torna um fator que estimula o bloqueio da transmissão do impulso nervoso na placa mioneural promovendo o surgimento da Hipertermia Maligna. Conclusão: Em síntese, por meio desse estudo, evidencia-se a atuação da succinilcolina como um mecanismo biomolecular que propicia a ativação de aspectos farmacogenéticos em pacientes suscetíveis à HM e, portanto, o uso do medicamento está contraindicado nessas situações.
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Durup, J., und M. A. Ech-Cherif El-Kettani. „Paths in the Conformational Space of Biopolymers“. In Advances in biomolecular simulations. AIP, 1991. http://dx.doi.org/10.1063/1.41310.

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Simonson, Thomas, und David Perahia. „Normal Mode Analysis of Large Symmetric Assemblies of Macromolecules“. In Advances in biomolecular simulations. AIP, 1991. http://dx.doi.org/10.1063/1.41311.

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Viviani, W., J. L. Rivail und I. G. Csizmadia. „Ab Initio SCF Calculations on Conformational Space of Peptide Models“. In Advances in biomolecular simulations. AIP, 1991. http://dx.doi.org/10.1063/1.41333.

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van Gunsteren, W. F. „Computer Simulation of Biomolecular Systems: Overview of Time-Saving Techniques“. In Advances in biomolecular simulations. AIP, 1991. http://dx.doi.org/10.1063/1.41334.

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Straub, John E., und Martin Karplus. „Molecular Dynamics of Carbon Monoxide After Photodissociation from Myoglobin“. In Advances in biomolecular simulations. AIP, 1991. http://dx.doi.org/10.1063/1.41335.

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Laughton, C. A., und S. Neidle. „DNA Triple Helices a Molecular Dynamics Study“. In Advances in biomolecular simulations. AIP, 1991. http://dx.doi.org/10.1063/1.41360.

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Ohlenbusch, H. H. „Macromolecular graphics of DNA, a tool of genetic architecture“. In Advances in biomolecular simulations. AIP, 1991. http://dx.doi.org/10.1063/1.41361.

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Solmajer, T., und E. L. Mehler. „Electrostatic Screening in Molecular Dynamics Simulations“. In Advances in biomolecular simulations. AIP, 1991. http://dx.doi.org/10.1063/1.41344.

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10

Chirico, G., und J. Langowski. „Simulation of the Structure and Dynamics of Superhelical and Linear DNA by a Second-Order Brownian Dynamics Algorithm with Hydrodynamic Interactions“. In Advances in biomolecular simulations. AIP, 1991. http://dx.doi.org/10.1063/1.41302.

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Berichte der Organisationen zum Thema "Biomoleculaire"

1

Lee, Luke P. Nanogap Biomolecular Junction. Fort Belvoir, VA: Defense Technical Information Center, Mai 2004. http://dx.doi.org/10.21236/ada427808.

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2

Frazier, John, Yaroslav Chusak und Brent Foy. Stochastic Simulation of Biomolecular Reaction Networks Using the Biomolecular Network Simulator Software. Fort Belvoir, VA: Defense Technical Information Center, Februar 2008. http://dx.doi.org/10.21236/ada484775.

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3

Micheel, Christine Marya. Biomolecular Assembly of Gold Nanocrystals. Office of Scientific and Technical Information (OSTI), Mai 2005. http://dx.doi.org/10.2172/877334.

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4

Manalis, Scott R. Development of Microdevices for Biomolecular Detection. Fort Belvoir, VA: Defense Technical Information Center, Juni 2008. http://dx.doi.org/10.21236/ada483978.

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5

David A. Case, Ph D., und Ph D. Charles L. Brooks III. Biomolecular Simulation Using Amber and CHARMM. Office of Scientific and Technical Information (OSTI), November 2004. http://dx.doi.org/10.2172/835140.

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6

Bayley, Hagan. Molecular Genetic Approaches to Biomolecular Materials. Fort Belvoir, VA: Defense Technical Information Center, November 2000. http://dx.doi.org/10.21236/ada391351.

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7

Stachowiak, Jeanne C., Mark Jackson Stevens, David B. Robinson, Steven S. Branda, Frank Zendejas, Robert J. Meagher, Darryl Yoshio Sasaki et al. Biomolecular transport and separation in nanotubular networks. Office of Scientific and Technical Information (OSTI), September 2010. http://dx.doi.org/10.2172/1008147.

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8

Osbourn, Gordon Cecil. Biomolecular decision-making process for self assembly. Office of Scientific and Technical Information (OSTI), Januar 2005. http://dx.doi.org/10.2172/882051.

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9

Hau-Riege, S. Utilizing plasma physics to create biomolecular movies. Office of Scientific and Technical Information (OSTI), Juli 2015. http://dx.doi.org/10.2172/1236128.

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10

Winfree, Erik, Jongmin Kim, Shaun Lee, Sarina Mohanty und Kristin Shantz. Biomolecular Computing by In Vitro Transcriptional Networks. Fort Belvoir, VA: Defense Technical Information Center, April 2004. http://dx.doi.org/10.21236/ada426916.

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