Thematische Bibliographien / Barhl1 / Dissertationen
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Dissertationen zum Thema „Barhl1“

Autor: Grafiati
Veröffentlicht am 25. Mai 2024

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1

Pöschl, Julia. „The role of the transcription factor BARHL1 in medulloblastoma“. Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-137752.

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2

Pöschl, Julia [Verfasser], und Ulrich [Akademischer Betreuer] Schüller. „The role of the transcription factor BARHL1 in medulloblastoma / Julia Pöschl. Betreuer: Ulrich Schüller“. München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2011. http://d-nb.info/1018615717/34.

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3

Bou-Rouphaël, Johnny. „A new role for Barhl1 in a cerebellar germinative zone as inhibitor of T-cell factors transcriptional activity“. Electronic Thesis or Diss., Sorbonne université, 2023. http://www.theses.fr/2023SORUS009.

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Le cervelet humain contient plus de 50 % des neurones cérébraux. Les neurones granulaires cérébelleux représentent la population neuronale majeure. Les progéniteurs des neurones granulaires (GNP), définis par l’expression de Atoh1, émergent à partir de la lèvre rhombique supérieure (URL), une zone germinative située dans le territoire cérébelleux. Au cours du développement, les GNP prolifèrent, migrent et se différencient. Chacun de ces processus est régulé par un certain nombre de facteurs de transcription et de voies de signalisation. Les « T-Cell Factors » (Tcf/Lef) » sont des effecteurs transcriptionnels agissant en aval de la signalisation Wnt/β-caténine. Bien que les Tcf soient transcriptionnellement actifs dans la URL, leur(s) fonction(s) et leur(s) régulateur(s) développementaux n'ont été étudié. Le facteur de transcription « BarH-like 1 » (Barhl1) est exprimé dans les GNPs engagés, situés dans des zones dépourvues d'une activité transcriptionnelle Tcf. Par conséquent, les objectifs de cette thèse étaient d'étudier les fonctions de Tcf et Barhl1 en tant que régulateurs du développement des GNPs chez le Xénope. Les données présentées dans cette thèse englobent une analyse approfondie des marqueurs majeurs impliqués dans le développement des GNPs chez les amphibiens, et une étude des fonctions de Barhl1 et Tcf dans ce processus développemental. Nos expériences de gain et de perte de fonction, ainsi que l'analyse transcriptomique en absence de Barhl1 dans le rhombomère 1 valident un rôle clé de Tcf en tant qu'activateur transcriptionnel de atoh1 et en tant qu'inducteur du territoire cérébelleux, et un rôle pour Barhl1 en tant qu'inhibiteur développemental de l’activité Tcf, permettant aux GNPs de sortir de l'URL. Nous avons identifié des gènes cibles clés inhibés par Barhl1, et impliqués dans le maintien d’une zone germinative
The human cerebellum hosts more than 50% of all brain neurons. Cerebellar granule neurons are the smallest and most abundant neurons. atonal homologue 1 (Atoh1)-expressing granule neuron progenitors (GNPs) emerge from the upper rhombic lip (URL), a germinative zone located in the cerebellar primordium and displaying features of a niche of neural stem cells. GNPs proliferate, migrate, and differentiate to settle into the internal granule layer. These processes are tightly regulated by a number of transcription factors and signaling pathways. T-Cell Factor/Lymphoid Enhancer-binding Factor (Tcf/Lef) are transcriptional effectors acting downstream of Wnt/β-catenin signaling. Although Tcf is transcriptionally active in the URL, neither its function(s) nor its developmental regulator(s) have been addressed in this area. The transcription factor BarH-like 1 (Barhl1) is expressed in committed GNPs located in areas devoid of Tcf transcriptional activity. The aims of this thesis were to investigate the functions of Tcf and of Barhl1 as regulators of GNPs development using amphibian as experimental model. The data presented in this work encompass a thorough analysis of the spatial and temporal expressions of key markers involved in GNP development in amphibian, and an investigation of Barhl1 and Tcf functions in this developmental process. Our gain and loss of function experiments, together with the transcriptomic analysis of Barhl1 depletion in the rhombomere 1 validate a key role for Tcf as a transcriptional activator of atoh1 and as an inducer of the URL territory, and for Barhl1 as a developmental inhibitor of Tcf activity allowing GNPs to exit the URL. We identified key genes inhibited by Barhl1 and involved in the maintenance of URL germinative zone
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Betin, Cansu. „Barely Transitive Groups“. Phd thesis, METU, 2007. http://etd.lib.metu.edu.tr/upload/3/12608605/index.pdf.

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A group G is called a barely transitive group if it acts transitively and faithfully on an infinite set and every orbit of every proper subgroup is finite. A subgroup H of a group G is called a permutable subgroup, if H commutes with every subgroup of G. We showed that if an infinitely generated barely transitive group G has a permutable point stabilizer, then G is locally finite. We proved that if a barely transitive group G has an abelian point stabilizer H, then G is isomorphic to one of the followings: (i) G is a metabelian locally finite p-group, (ii) G is a finitely generated quasi-finite group (in particular H is finite), (iii) G is a finitely generated group with a maximal normal subgroup N where N is a locally finite metabelian group. In particular, G=N is a quasi-finite simple group. In all of the three cases, G is periodic.
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Sena, Elena. „The Transcription Factor Barhl2 Inhibits Wnt Canonical Signaling during Xenopus Embryogenesis“. Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS090/document.

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Le développement embryonnaire est un processus hautement contrôlé où différentes voies de signalisation se coordonnent pour la construction d'un organisme. L'une des principales voies de signalisation impliquées dans ce processus est la voie canonique Wnt. La longue quête pour comprendre la cascade de signalisation Wnt/β-catenine a révélé que la réponse transcriptionelle induite par le signal Wnt/β-catenine est dépendante du contexte, ou compétence, cellulaire. Peu de choses sont connues sur les évènements moléculaires qui influencent cette compétence cellulaire. Dans les embryons de X. laevis Wnt/β-catenine est le signal inducteur pour l'Organisateur de Spemann. On ne sait pas ce qui limite l'activité Wnt dans ce territoire et par voie de conséquence la taille de l'Organisateur. Les résultats présentés dans ce manuscrit de thèse montrent que le facteur de transcription Barhl2 affecte le développement de l'organisateur de Spemann. Nous démontrons que Barhl2 inhibe l'activité Wnt via son interaction avec le corépresseur Groucho et le facteur de transcription Tcf, et mobilise l'activité de Hdac1 qui agit sur la structure chromatinienne. En utilisant des expériences in vitro et in vivo sur des cellules en culture et des embryons de Xénope nous démontrons que la régulation de Barhl2 sur les activités Groucho-Tcf est maintenue pendant l'embryogenèse et joue un rôle dans le confinement des progéniteurs neuraux dans le cerveau. Ensemble, nos résultats fournissent un mécanisme nouveau et important agissant sur le contrôle de l'activité transcriptionelle Wnt et la compétence des cellules à répondre à ce signal
Embryonic development is a highly controlled process where different signaling pathways participate into the elaboration of an organism. One of the main signaling pathways is the Wnt canonical pathway. The long-lasting search to understand Wnt/β-catenin transduction cascade revealed that the net transcriptional read out of Wnt/β-catenin signaling is highly dependent on the cellular context. In X. laevis embryos Wnt/β-catenin signaling is the informative signal for the Spemann Organizer induction. However little is known on what limits Wnt activity in this territory and consequently the size of the Spemann Organizer. The results presented in this manuscript provide evidence that the evolutionarily conserved transcription factor Barhl2 limits the development of the Spemann organizer. In this territory Barhl2 inhibits Wnt activity via its interaction with the co-repressor Groucho and the transcription factor Tcf. It participates to the recruitment of the chromatin remodeling enzyme, Hdac1 that represses the expression of Spemann organizer genes. Using a Xenopus tropicalis Tcf reporter line we demonstrate that Barhl2 inhibitory effect on Groucho-Tcf activities is maintained during embryogenesis and plays a role in the confinement of neural progenitors in the brain. Together, our results provide a new and important mechanism for the control of Wnt transcriptional activity
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Kuzucuoglu, M. „Barely transitive permutation groups“. Thesis, University of Manchester, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233097.

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7

Parish, Elisa Victoria. „Interactions between Pax6, Barhl2 and Shh in the early patterning of the mammalian diencephalon“. Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/23387.

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Diencephalic development requires the transcription factors Pax6 and Barhl2 in order to proceed correctly. Both genes are necessary for the normal development of the organizer region known as the zona limitans intrathalamica (ZLI). The ZLI goes on to pattern the diencephalon via its secretion of the morphogen Shh, which inhibits the expression of Pax6. These findings suggest that interactions between Pax6, Barhl2 and Shh may be involved in the control of diencephalic development. This project aims to characterise these interactions and investigate their roles. The expression domains of Pax6 and Barhl2 were mapped during the early development of the mouse diencephalon. Qualitative approaches were employed to confirm the high complementarity of their expression domains and obtain evidence of a mutually repressive relationship existing between the two genes. The findings from a quantitative analysis suggested that this inhibition is incomplete within the thalamus. Investigations using the Pax6-null mutant mouse confirmed that in the absence of Pax6 the thalamic Barhl2 expression domain expands beyond the ventricular zone, the site of thalamic neurogenesis. The influence of Shh signalling on the expression of Pax6 and Barhl2 was investigated via a gain-of-function approach utilising in utero electroporation to activate the Shh pathway. This led to a downregulation of both Pax6 and Barhl2 within the thalamus. In Shh loss-of-function experiments drug treatment with the Shh antagonist vismodegib led to an upregulation of Barhl2 and the loss of the GABAergic pTh-R in the Pax6-null mutant thalamus, but not in the wild type thalamus, suggesting that Pax6 and Shh may be required to inhibit Barhl2 in order for GABAergic neurogenesis to proceed. Barhl2 expression was detected in the Shh-null mutant mouse confirming that, in contrast with their homologues in Drosophila, Shh may be expressed downstream of Barhl2. Together these findings have been used to develop a novel model of thalamic development in which Barhl2 induces ZLI development, inhibition of Barhl2 by Pax6 restricts its expansion, and secretion of Shh by the ZLI then goes on to inhibit Pax6 and Barhl2 in the pTh-R while mutual repression between Pax6 and Barhl2 modulates neurogenesis in the more caudal regions of the thalamic neuroepithelium.
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Juraver-Geslin, Hugo. „Barhl2, un inhibiteur prolifératif des progéniteurs neuraux dans le développement du diencéphale caudal“. Paris 6, 2013. http://www.theses.fr/2013PA066101.

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Notre équipe s’intéresse à la mise en place de la partie caudale du cerveau antérieur qui génère le thalamus, un processeur de l’information vers le cortex, et son centre organisateur, la zona limitans intrathalamica (ZLI). La ZLI, via la sécrétion des facteurs Wnt et Sonic HedgeHog (Shh), contrôle l’acquisition d’identité et la croissance de toute la partie caudale du cerveau antérieur. Wnt et Shh sont essentiels dans le contrôle de la survie et de la prolifération neurale au cours du développement. Chez les amphibiens, et les rongeurs, le gène à homéodomaine Barhl2 est exprimé dans le neuroépithelium du cerveau antérieur avec des ligands Wnt et Shh. Chez le xénope, Barhl2 limite la prolifération des progéniteurs neuraux du diencéphale et contrôle l’organisation du neuroépithélium. Barhl2 agit via une fonction non apoptotique de la Caspase-3, qui inhibe l’accumulation et l’activation de la caténine, l’intermédiaire majeur de la voie Wnt. En parallèle, Barhl2 est crucial dans l’élaboration du champ histogénique qui génère la ZLI et le thalamus. Un réseau dynamique impliquant barhl2, iroquois (irx), otx et pax6 est en jeu pour l’établissement de ces territoires présomptifs. Mon travail, ainsi que des études chez le poisson zèbre, démontre que barhl2, otx2 et irx3 sont des gènes maîtres dans le prépatterning de la ZLI et que ce rôle est conservé chez les vertébrés
Our team focuses on the development of the caudal forebrain that generates the thalamus, a processor of information to the cortex, and its organizing center, the zona limitans intrathalamica (ZLI). ZLI, through the secretion of Sonic Hedgehog (Shh) and Wnt ligands controls the acquisition of identity and the growth of the entire caudal forebrain. Shh and Wnt are the main pahways that controls the survival and proliferation of neural progenitors during development. In amphibians and rodents, the homeodomain containing gene Barhl2 is expressed with Shh and Wnt ligands in the forebrain neuroepithelium. In Xenopus, Barhl2 limit the proliferation of diencephalic neural progenitors and controls the neuroepithelium architecture. Barhl2 acts through an unconventional function of Caspase-3, the major effector of apoptosis, which inhibits the accumulation and activation of βcaténine. My work also showed that Barhl2 is crucial in the development of the histogenic field that generates the ZLI and thalamus. A dynamic network involving barhl2, iroquois (irx), otx and pax6 is at play in establishing the presumptive territories. My work, and studies in zebrafish, shows that barhl2, otx2 and irx3 are masters prepatterning genes of the ZLI and this role is conserved in vertebrates
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Olivesi, Dominique. „Virgile Barel : 1889-1979 /“. Nice : Serre, 1996. http://catalogue.bnf.fr/ark:/12148/cb36688081n.

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10

Lewis, Colin A. „Barkly East bells and the British Empire“. The Ringing World, 2002. http://www.ringingworld.co.uk.

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Colin Lewis was Professor of Geography at Rhodes University, Grahamstown, South Africa from 1989 until his retirement at the end of 2007. In 1990, with the strong support of the incumbent Vice-Chancellor, Dr Derek Henderson, he instigated the Certificate in Change Ringing (Church Bell Ringing) in the Rhodes University Department of Music and Musicology - the first such course to be offered in Africa. Since that date he has lectured in the basic theory, and taught the practice of change ringing. He is the Ringing Master of the Cathedral of St Michael and St George, Grahamstown, South Africa.
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Shi, Yibing. „Barely visible impact damage in polymer composite laminates“. Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334270.

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Cárdenas, Bunsen José Alejandro. „Mercedes López-Baralt, Guamán Poma, autor y artista“. Pontificia Universidad Católica del Perú, 2013. http://repositorio.pucp.edu.pe/index/handle/123456789/100915.

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Harrison, Paul. „Being barely there : thinking through the break-up of idealism“. Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340438.

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14

Li, Lin. „L'expression de BARD1 et sa fonction potentielle dans le cancer = (Expression of BARD1 isoforms and possible function in cancer) /“. Genève : [s.n.], 2007. http://www.unige.ch/cyberdocuments/theses2007/LiL/these.pdf.

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Th. Univ. Genève, 2007 ; Méd. 10524.
Avec des articles de l'auteur parus dans la presse professionnelle. Contient un résumé (1 p.) et une introduction (5 p.) en français. A paru également en version électronique. Bibliogr.
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Savage, Darryl B. „Nutritional influences on reproductive performance of beef cattle in the Barkly Tableland /“. St. Lucia, Qld, 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17977.pdf.

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Kane, Wendi. „Working Hard and Barely Making it: Ideological Contradictions and the Working Poor“. Master's thesis, University of Central Florida, 2009. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4049.

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The existence of large, relatively comfortable, middle and working classes is what has set the advanced capitalist societies apart from most societies throughout history. These classes, while not quite "privileged," offer the hope of opportunity and upward social mobility for those who work hard. Yet in the last 30 years a growing class of "working poor" has emerged who invest many hours working but at wages that keep upward social mobility beyond their grasp. The existence of the working poor, it seems, dispels a key element in the ideology of individualism; they work hard yet do not "get ahead." This study addresses the contradiction presented by the working poor; specifically, do the working poor support the ideology of individualism? Prior research finds that the disadvantaged justify the system that inhibits them from having a better quality of life (Jost, et al. 2003). This study, however, suggests that the working poor are more conscious of the ideology's failure to explain their lack of mobility in a system that promises opportunity to those who work hard. Research data were generated through the use of telephone surveys in five counties in Central Florida with approximately 1571 respondents. Several measures of "working poor" were created; moreover, respondents within these categories tended to disagree with the "work hard, get ahead" ideology. Respondents who viewed their financial situation as getting worse, unable to grasp the "upward mobility" promise of the American Dream, also significantly disagreed with the ideology.
M.A.
Department of Sociology
Sciences
Applied Sociology MA
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Kane, Wendi Belinda. „Working hard and barely making it ideological contradictions and the working poor /“. Orlando, Fla. : University of Central Florida, 2009. http://purl.fcla.edu/fcla/etd/CFE0002518.

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Adu-Tutu, K. O., W. B. McCloskey, S. H. Husman, P. Clay, M. J. Ottman, E. C. Martin und T. Teegerstrom. „Weed Management and Agronomic Performance of a Cotton-Barely Double Crop Rotation“. College of Agriculture, University of Arizona (Tucson, AZ), 2005. http://hdl.handle.net/10150/198166.

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The tillage operations required to grow an annual barley and cotton crop rotation were reduced by eliminating tillage prior to planting cotton, eliminating cultivations for weed control in cotton, and especially by eliminating tillage following cotton. A light activated, weed sensing automatic spot-spray system reduced the amount of spray volume and herbicide used by 40% to 60% at Marana and 36% to 56% at Maricopa in 2004. At Maricopa, a large number of volunteer cotton plants in the furrows of early planted no-till cotton reduced the spray volume savings from using the weed sensing automatic spot-spray system. Weed control was similar with the weed sensing, automatic spot-spray system compared to the conventional continuous spray system for most weed species but weeds with narrow leaf, upright leaf canopies such as sprangletop, barley and skeleton weed were more difficult to detect and control. In both Marana and Maricopa, there were yield differences between treatments related to planting date, with late-planted cotton yielding less than early-planted cotton. At Marana, the early-planted conventional tillage cotton out-yielded the barley cover crop, early-planted no-till cotton treatment. At Maricopa, there were no yield differences between the two early planted cotton treatments; however, the late-planted conventionally tilled cotton yielded 28% more than the late-planted no-till cotton. Although the yield comparisons are not yet definitive, it appears that in some situations no-till cotton may yield less than conventionally tilled cotton. At Maricopa, the height of cereal crop stubble did not affect subsequent cotton establishment, field populations, plant height or lint production (2003 and 2004) and the position or node of the first fruiting branch and the first retained boll were similarly unaffected in 2004.
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Ybos, Cynthia. „Barely There Tales: A Phenomenological Study of Stories Told by Pre-service Teachers“. ScholarWorks@UNO, 2010. http://scholarworks.uno.edu/td/1240.

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Teacher stories were once relegated to informal gatherings but more recently this aspect of teacher development is being carefully studied in more formalized settings because it is believed to be an important part of teacher development. New ways are being sought to use various aspects of storytelling to help pre-service teachers develop important teaching skills through reflection on experience, dialogue journals, case studies and autobiography. Despite these efforts at the university level, it is especially difficult for pre-service teachers to integrate and apply theories from their methods courses to actual classroom practice. Less effort has been focused on storytelling processes that may occur outside these formal approaches. This study, therefore, looked at how pre-service teachers used stories told in an informal setting to process aspects of learning to teach. This study revealed that pre-service teachers engage in story telling for reasons and in ways that are different from teacher educator intents. Using interviews and private dialogues, patterns of when, how and why six pre-service teachers used oral stories emerged that illuminate challenges to using personal and appropriated stories in coursework. The findings of this study include how oral storytelling is used by pre-service teachers to process emotion and demonstrate specific identities and personal characteristics.
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Baril, Lisa Marie. „Change in deciduous woody vegetation, implications of increased willow (Salix spp.) growth for bird species diversity, and willow species composition in and around Yellowstone National Park's Northern range“. Thesis, Montana State University, 2009. http://etd.lib.montana.edu/etd/2009/baril/BarilL1209.pdf.

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Deciduous woody vegetation (DWV) in Yellowstone's northern range is a rare, but important habitat type. Including willow, alder, aspen, and cottonwood, DWV was limited in height and areal extent since the early 1900s. Since the mid-1990s; however, DWV has increased in height and areal extent in some locations. Previous studies regarding DWV change have focused on quantifying change in vegetation growth in areas of limited extent and none have quantified increased DWV growth at the scale of the landscape. Furthermore, no studies have evaluated the implications for increased growth of DWV for wildlife in the region or how DWV species themselves may influence rates of growth. In this thesis I evaluate change in DWV within wetland and riparian areas using aerial photographs from 1991 and 2006. I also investigate how an increase in willow, the dominant component of DWV in the region, has likely influenced bird diversity. Finally, since willow species vary with respect to genetic limitations on growth and reproduction that in turn may influence observed patterns of growth; I examine willow species composition across the northern range. Results of the air photo interpretation revealed a 170% increase in DWV. Most plots that increased did so by recruitment rather than densification; however, DWV was difficult to detect below 100 cm indicating that the number of plots increasing by recruitment may have been overestimated. Bird community variables were examined in three willow growth conditions: height suppressed, recently released, and previously tall (tall prior to observed increase in growth). I found that willow structure generally increased in complexity from structurally simple height suppressed willows to structurally complex previously tall willows and that this allowed for greater bird richness, abundance, diversity, and the abundance of several willow dependent bird species. I also found that willow species composition was similar and diverse between the released and previously tall condition, but that the suppressed condition was dominated by a singe species. I conclude that increased DWV has allowed for greater bird diversity in the northern range and that increased willow growth in the suppressed condition may be influenced by species composition there.
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Liu, Xuan. „BARF1 sequence analysis and functional significance in EBV-Related disorders“. Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B36190445.

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Bartl, Guido [Verfasser], und A. [Akademischer Betreuer] Hangleiter. „Interferometrische Bestimmung von absoluten Kugelradiustopografien / Guido Bartl ; Betreuer: A. Hangleiter“. Braunschweig : Technische Universität Braunschweig, 2010. http://d-nb.info/117582898X/34.

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Liu, Xuan, und 劉絢. „BARF1 sequence analysis and functional significance in EBV-Related disorders“. Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B36190445.

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Bartl, Daniel [Verfasser]. „Robust techniques for utility maximization and related problems / Daniel Bartl“. Konstanz : KOPS Universität Konstanz, 2019. http://d-nb.info/1192665627/34.

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Lu, Chi-Sheng. „The role of BRCA1/BARD1 in breast cancer a dissertation /“. San Antonio : UTHSC, 2008. http://proquest.umi.com.libproxy.uthscsa.edu/pqdweb?did=1605126591&sid=11&Fmt=2&clientId=70986&RQT=309&VName=PQD.

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MARTORELLI, DEBORA. „BARF1 AS A NEW THERAPEUTIC TARGET FOR EBV-ASSOCIATED MALIGNANCIES“. Doctoral thesis, Università degli studi di Ferrara, 2010. http://hdl.handle.net/11392/2389347.

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While Epstein-Barr virus-specific cytotoxic T lymphocytes (EBV-CTLs) have been used successfully for the prophylaxis and treatment of the highly immunogenic post-transplant lymphoproliferative disorders, the clinical experience for other EBV-associated malignancies, such as Hodgkin's lymphoma and undifferentiated nasopharyngeal carcinoma (NPC), is limited and the results obtained so far indicate that EBV-CTLs are less effective in these settings. Decreased CTL efficacy most likely reflects immune evasion strategies by tumor cells, including down-regulation of immunodominant EBV proteins and the weak immunogenicity of the viral proteins expressed. One of the possible approaches to overcome these limitations is the identification of additional immunogenic viral proteins expressed by tumor cells that may serve as tumor-associated antigens to be targeted by improved CTL induction and expansion protocols. We have recently demonstrated that NPC patients show strong spontaneous CD4+ and CD8+ T cell responses specific for the EBV-encoded oncogenic protein BARF1. We also showed that BARF1 provides immunogenic HLA-A*0201-restricted epitopes, suggesting that exploitation of the immunogenic features of this viral antigen may help improve the current immunotherapeutic strategies for EBV-associated malignancies. On these grounds, we characterized more extensively the immunogenic properties of BARF1 with the final goal to develop improved protocols of adoptive immunotherapy based on the use of EBV-CTLs enriched in BARF1-specific effectors. In particular, we identified and validated additional BARF1 CTL epitopes presented in the context of common HLA class I alleles. These results strictly correlate to those deriving from a high-resolution HLA genotyping of a large series of NPC, giving a precise estimate of the immunogenicity of BARF1 in relation to the HLA class I profile of Italian NPC patients. To fully exploit the immunologic properties of BARF1, we are also developing and characterizing BARF1-specific monoclonal antibodies that may be of both diagnostic and therapeutic usefulness in these clinical settings. In future perspective, the proposed research may provide a strong rationale for the clinical application of improved adoptive immunotherapy protocols for the treatment of EBV-associated malignancies, particularly the less immunogenic forms, such as NPC and, possibly, Hodgkin’s lymphoma.
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Turrini, Riccardo. „Targeting BARF1 for the therapeutic control of EBV-associated malignancies“. Doctoral thesis, Università degli studi di Padova, 2010. http://hdl.handle.net/11577/3427092.

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The Epstein-Barr virus is a y-herpesvirus that preferentially infects human Blymphocytes. It is estimated that 95% of worldwide population is infected, but usually the infection happens during childhood and is asymptomatic. Beside the association to a self-limiting lymphoproliferative disease, infectious mononucleosis, the virus is related to the development of some human cancerous forms, which are characterized by different patterns of viral latency, like Burkitt’s lymphoma (BL) and some forms of gastric carcinoma (GC), Hodgkin’s lymphoma (HL) and nasopharyngeal carcinoma (NPC), and, finally, PTLD, post-transplant lymphoproliferative diseases. In addition to the latency genes, it is known the expression of different non-polyadenilated RNA (EBER) and, especially in the cases of NPC and GC, the expression of a transmembrane protein belonging to the lytic cycle, BARF1. BARF1 is a 221-aa protein with a transmembrane domain at the C-terminal. Only recently, its transforming and immortalizing roles have been demonstrated in human cells. Moreover, its extracellular domain can be cleaved and can act in a paracrin way as a growth factor on bystander cells, and it owns mitogenic activities. Nevertheless, its mitogenic and mutagenic properties are not well understood yet, but the importance of this protein in the pathways of neoplastic progression and its expression only on infected cells (or at the surface of those that can bind its secreted forms) render BARF1 an optimal target for a therapeutic approach of EBV-related tumours. Different strategies for the treatment of EBV-related neoplasms are currently in use in clinic. Some strategies reside on the reduction of the immunosuppressive regimen, on the exploitation of gene therapy, on the use of chemotherapy or antiviral drugs, or on the approaches of immunotherapy. The use of autologous or HLA-matched cytotoxic T lymphocytes (CTL) proved to be efficient and usually devoided of side effects, especially for PTLD patients. A different aspect of immunotherapy is based on the use of monoclonal antibodies (mAb), as it was already demonstrated in different clinical settings by the use of rituximab. In this PhD work, the generation and the in vitro evaluation of different monoclonal antibodies specific for BARF1 are described. Moreover, once their activity was established on cell culture in vitro, this approach was translated to some pre-clinical models, using immunodeficient mice bearing EBV-positive tumours. Also in these experiments, the antibodies proved to be therapeutically efficient. On one side, the use of mAb for the diagnosis and for the cure of malignancies is acquiring an increasing importance in the clinic, thanks to the specificity of action of these molecules and to their relative easiness of use, if compared to the cellular adoptive therapy. On the other side, although BARF1 functions and interactions with other proteins or cells are not well studied yet, it can be regarded as a promising target for EBV-related malignancies, since it is expressed in NPC and GC and owns important transforming properties, while being a lytic cycle protein.
Il virus di Epstein-Barr è un γ-herpesvirus che infetta preferenzialmente i linfociti B umani. Si stima che il 95% della popolazione mondiale sia infettata, ma normalmente tale infezione avviene nell’infanzia ed è asintomatica. Oltre ad essere l'agente causale di una malattia linfoproliferativa autolimitante, la mononucleosi infettiva, la presenza del virus è associata ad alcune neoplasie umane, caratterizzate da diversi pattern di espressione genetica. Alcune delle neoplasie EBV-associate sono il linfoma di Burkitt (BL) e alcune forme di carcinoma gastrico (GC), il linfoma di Hodgkin (HL) e il carcinoma nasofaringeo (NPC), e infine le malattie linfoproliferative post-trapianto (PTLD). Oltre ai geni di latenza, è nota l’espressione di diversi RNA non poliadenilati (EBER) e, soprattutto nei casi di NPC e di GC, l’espressione da parte delle cellule infettate di una proteina transmembrana del ciclo litico, BARF1. BARF1 è una proteina di 221 aminoacidi, con una porzione transmembrana al C-terminale. Solo recentemente ne è stato dimostrato il ruolo trasformante ed immortalizzante in cellule umane. Inoltre, il dominio extracellulare può essere tagliato, ed è in grado di agire in modo paracrino come fattore di crescita per le cellule adiacenti, possedendo infatti attività mitogena. In generale, tuttavia, le attività mitogene e mutagene non sono state ancora completamente elucidate, ma l’importanza di questa proteina nei pathway di progressione neoplastica e la sua espressione unicamente nelle cellule infettate (o in quelle che ne legano la forma secreta) la rendono un ottimo candidato come bersaglio per un approccio terapeutico delle neoplasie EBV-correlate. Esistono diversi orientamenti terapeutici nei confronti delle neoplasie EBV-relate; alcune strategie prevedono la riduzione del regime di immunosoppressione, soprattutto per il trattamento di PTLD, la somministrazione di farmaci antivirali, la terapia genica, l’uso di chemioterapici e approcci di immunoterapia. L’uso di linfociti T citotossici (CTL) autologhi o da donatori compatibili si è dimostrata efficace e generalmente priva di effetti collaterali, soprattutto in pazienti affetti da PTLD. Un altro aspetto dell’immunoterapia prevede l’utilizzo di anticorpi monoclonali (mAb), come già dimostrato in ambito clinico dall'utilizzo di rituximab. In questo progetto di Dottorato viene descritta la generazione e la valutazione in vitro di diversi anticorpi monoclonali specifici per BARF1. Inoltre, una volta dimostratane l'attività su colture cellulari in vitro, si è traslato l'approccio ad alcuni modelli pre-clinici sfruttando topi immunodeficienti portatori di tumore EBV-positivo. Anche in questi esperimenti è stato possibile dimostrare l'efficacia terapeutica degli anticorpi prodotti. Da un lato, l’utilizzo di mAb sia nella diagnosi che nella cura di neoplasie sta assumendo un’importanza crescente in ambito clinico, grazie alla specificità di azione di queste molecole e alla loro relativa facilità d’uso, soprattutto se paragonati all’immunoterapia cellulare adottiva. Dall’altro, BARF1, benchè non ne siano ancora state completamente studiate le funzioni e le interconnessioni con altre molecole o cellule, è sicuramente un target promettente per i tumori EBV-relati, in quanto, nonostante sia una proteina espressa durante il ciclo litico, è presente soprattutto nei casi di NPC e di GC, e possiede importanti funzioni trasformanti, anche con azione paracrina.
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Adamovich, Aleksandra Igorevna. „Functional Analysis of BARD1 and BRCA1 Variants of Uncertain Significance in Homology-Directed Repair“. The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1563316267936516.

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Errera, Reagan Michelle. „Inhibition and success of prymnesium parvum invasion on plankton communities in Texas, USA and prymnesium parvum pigment dynamics“. Thesis, Texas A&M University, 2003. http://hdl.handle.net/1969.1/5985.

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Prymnesium parvum Carter, a haptophyte species capable of forming harmful algal blooms (HABs), has been identified in fresh and brackish water habitats worldwide. In Texas, P. parvum blooms have diminished local community revenues from losses to tourism, fishing, and hatchery production. In this thesis, P. parvum dynamics were studied using in-situ microcosm experiments at Lake Possum Kingdom, Texas during three seasons (fall, winter, spring) in 2004-2005. Specifically, nutrient additions were used to test the hypothesis that increased nutrient levels would not enhance P. parvum's ability to invade phytoplankton communities. In addition to full nutrient additions to levels of f/2 media, other treatments included nutrient additions deficient in either nitrogen (N) or phosphorus (P). Additionally, barley straw extract was tested as a growth inhibitor to prevent P. parvum blooms. Furthermore, P. parvum initial population density was examined to test the hypothesis that increased initial populations could promote an increase in P. parvum population densities. Findings indicated that P. parvum populations in Lake Possum Kingdom would not likely gain a selective advantage over other species when inorganic nutrients (nitrogen and phosphorus) were not limiting. P. parvum did, however, gain an advantage during both N- and P-limited conditions as indicated by toxicity, cell concentrations, and bulk phytoplankton community shifts. Furthermore, P. parvum blooms in Lake Possum Kingdom would likely not be inhibited by barley straw extract application. Initial population densities affected the final population density, but only when initial populations were low. A method to quickly and accurately detect the presence of P. parvum is needed due to P. parvum's potential to cause toxic and lethal blooms. This thesis tested whether P. parvum photopigments are conservative regardless of growth conditions and could be used to quantify the relative abundance of P. parvum in mixed community samples. If biomarker pigments are conservative, then an optimized version of CHEMTAX could be employed as an alternative diagnostic tool to microscopy for enumeration of P. parvum. However, P. parvum pigments in the Texas strain were not conservative throughout the growth cycle and therefore may not be a reliable indicator of cell abundance.
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Feki, Anis. „Rôle de BARD1 comme suppresseur de tumeur dans un modèle animal /“. Genève : [s.n.], 2004. http://www.unige.ch/cyberdocuments/theses2004/FekiA/these.pdf.

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Christensen, Devin Eugene. „Identifying substrate and E2 interactions of the BRCA1/BARD1 ubiquitin ligase /“. Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/9222.

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Madgett, Elizabeth Bryony. „Checkpoint function and replication dynamics in brca1 and bard1 DT40 cells“. Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613163.

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Belliveau, Tammie. „Barely a whisper in the system, parents' perspectives on the prevention of foster care placement“. Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/mq21874.pdf.

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Welter, John T. „Oblique angle pulse-echo ultrasound characterization of barely visible impact damage in polymer matrix composites“. University of Dayton / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1575295152635788.

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Bartl, Alexander [Verfasser], Achim [Akademischer Betreuer] Schwenk und Segovia Almudena [Akademischer Betreuer] Arcones. „Neutrino Interactions with Supernova Matter / Alexander Bartl ; Achim Schwenk, Almudena Arcones Segovia“. Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2016. http://d-nb.info/1117797171/34.

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Kaufmann, Aisling. „The role of the BARD1 BRCT domains in the DNA damage response“. Thesis, University of Dundee, 2014. https://discovery.dundee.ac.uk/en/studentTheses/8c8c745f-8b73-420f-b264-2b12334195e7.

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The DNA within a cell is damaged on a continuous basis by both endogenous and exogenous agents. One of the most dangerous types of damage a cell can incur are DNA Double stranded breaks (DSBs) as failure to repair these types of lesions can lead to mutations, cell death and cancer. In order to maintain genome integrity, cells have several different mechanisms to repair various types of DNA damage. BRCA1 is a tumour suppressor gene commonly mutated in many inherited breast and ovarian cancers. BRCA1 is fundamental to the repair to DNA damage especially the faithful repair of DSB by homologous recombination (HR) as loss of BRCA1 results in aberrant HR, chromosomal translocation and cancer. BRCA1 is almost always found in the nucleus bound to BARD1. BARD1 retains BRCA1 in the nucleus and enhances the E3 ubiquitin ligase function of BRCA1. The importance of BRCA1 in the repair of DNA DSBs has been extensively researched, however the role of BARD1 in repair remains unknown. Similar to BRCA1, BARD1 contains tandem BRCT domains at its C-terminus which are important for binding phosphorylated proteins involved in DNA repair. Mutations in the BARD1 BRCT domains have been discovered in a few breast and ovarian cancers which suggested that BARD1 is important in the DNA damage response (DDR) independent of its function in stabilising BRCA1. Loss of the BARD1 BRCT domains also results in a decrease in the ability of cells to carry out HR. This thesis examines the contribution of the BARD1 BRCT domains to the repair of DNA DSBs. Using homologous recombination assays and colony survival assays, Bard1 DT40 cells reconstituted with BARD1?BRCT showed a significant decrease in their ability to carry out HR and were also extremely sensitive to PARP inhibitors suggesting that the BARD1 BRCT domains do indeed play an important role in HR. Work carried out in this thesis suggests that BARD1 contributes to the stabilisation of the BRCA1-C complex which is important in the repair of DSBs. The BARD1 BRCT domains also showed defects in localisation and delayed recruitment to sites of damage. The defects in HR and localisation seen in the absence of the BARD1 BRCT domains potentially implicate a functional role for the BARD1 BRCT domains in DSB repair. Potential BARD1 BRCT domain interacting proteins were also identified my Mass spectrometry, which may shed some light onto the functional role of BARD1 in DNA repair.
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Lelièvre, Jean. „Problématique d'incohérence des registres d'inventaire chez Marcel Baril Ltee : diagnostic et recommandations /“. Thèse, Chicoutimi : Université du Québec à Chicoutimi, 1986. http://theses.uqac.ca.

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Mémoire (M.P.M.O.)-- Université du Québec à Chicoutimi, 1986.
Ce mémoire a été réalisé à l'Université du Québec en Abitibi-Témiscamingue dans le cadre du programme de maîtrise en gestion des petites et moyennes organisations extensionné de l'UQAC à l'UQAT. CaQCU Document électronique également accessible en format PDF. CaQCU
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Bartl, Bettina Uta [Verfasser]. „Der Einfluss der Lagerung von Erythrozytenkonzentraten auf die Komplementaktivierung / Bettina Uta Bartl“. Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1133492800/34.

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Timofejeva, Oksana. „Formation of Barely Soluble Compounds in the CuSO4 – K4P2O7 – H2O and CuSO4 – (NH4)4P2O7 – H2O Systems“. Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2009. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2009~D_20090526_111121-30909.

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At least three poorly soluble compounds can be formed in the CuSO4 – K4P2O7 – H2O system: a single salt Cu2P2O7.5H2O and two dimorph’s both having chemical formula Cu3K2(P2O7)2.3H2O. A previously known form of Cu3K2(P2O7)2.3H2O (we named it Dimorph A) transforms into a novel Dimorph B, which has a different structure. The similarities between the XRD patterns and vibrations spectra of copper–ammonium and copper–potassium Dimorph’s B imply that they are isostructural. The values of the angle for copper–potassium and copper–ammonium salts and Cu2P2O7.5H2O are relatively low and vary within a narrow range (123.1 – 127.1°). The formation of the compounds significantly depends on the conditions of the experiment. A double salt in the CuSO4 – K4P2O7 – H2O system may be formed after some time in the reaction mixture as a result of the following heterogeneous reaction: 3Cu2P2O7∙5H2O↓ + H2P2O72– + 4K+ → 2Cu3K2(P2O7)2∙3H2O↓ + 2H+ + 9H2O This reaction has not been previously described for any polyphosphate system. Therefore, novel results of scientific investigation are presented. The rate, duration and yield of heterogeneous reaction substantially depend on pH of the solution, [Cu2+ + P2O74–] and n ([P2O74–] / [Cu2+]). At a relatively low pH the induction time is high, the reaction rate is low and duration is long. The maximal yields close to 100% can be achieved when [Cu2+ + P2O74–] = 0.1 M. At increased pH values, the induction time, the yield and duration of the reaction diminish... [to full text]
Naudojant IR-spektrometrijos, rentgenofazinės analizės, atominės absorbcinės spektroskopijos, kolorimetrijos analizės metodus buvo ištirta sistemose CuSO4 – K4P2O7 – H2O ir CuSO4 – (NH4)4P2O7 – H2O susidarančių mažai tirpių junginių sudėtis, jų susidarymo dėsningumai ir vykstančios reakcijos, įvairių veiksnių įtaką nuosėdų sudėčiai ir struktūrai. Nustatyta, kad sistemoje CuSO4 – K4P2O7 – H2O, be jau žinomų mažai tirpių junginių (paprastosios druskos Cu2P2O7 ∙ 5H2O ir dvigubosios druskos Cu3K2(P2O7)2 ∙ 3H2O), susidaro ir naujas mokslinėje literatūroje neaprašytas junginys (Dimorfas B), dvigubajai druskai patiriant polimorfinį perėjimą. Polimorfinio perėjimo trukmė labai priklauso nuo pH ir reaguojančių jonų koncentracijų. FTIR duomenų analizė parodė, kad difosfato jonų energetinė būsena Cu – K ir Cu – NH4 Dimorfuose B panaši. Jų rentgenogramos yra panašios, tikėtina, kad šie junginiai – izostruktūriniai, jų kristalinės gardelės tipas – monoklininis. Naudojant Lazarevo lygtį, bei Rulmonto priklausomybę buvo apskaičiuoti Cu – K ir Cu – NH4 Dimorfų A ir B bei paprastosios druskos P – O – P kampai, gauta, kad jie mažai keičiasi siaurame 123,1 – 127,1 º intervale. Nustatyta, kad dviguboji druska susidaro iš paprastosios, vykstant heterogeninei reakcijai: 3Cu2P2O7 ∙ 5H2O↓ + H2P2O72– + 4K+ → 2Cu3K2(P2O7)2∙ 3H2O↓ + 2H++ 9H2O. Mokslinėje literatūroje tokia reakcija neaprašyta jokiai difosfatų sistemai, jos tyrimo duomenys yra nauji. Taip pat nustatyta, kad heterogeninės reakcijos... [toliau žr. visą tekstą]
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Rice, Ian S. „Honors Thesis: BRCA1 Interactions with BACH1, BARD1, and CHK2: Recent Evidence and Potential Developments in the Diagnosis, Treatment, and Prevention of Human Breast Cancer“. Miami University Honors Theses / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=muhonors1114185039.

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Partorp, David. „Att gestalta nordisk mytologi genom berättarteknik : Berättarteknik i spel“. Thesis, University of Skövde, School of Humanities and Informatics, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-3363.

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Denna rapport avser verket Norse som jag – David Partorp – och min andra gruppmedlem – Jesper Flarup – har skapat. Norse är en modul till The Elder Scrolls IV: Oblivion (2006) med nordisk mytologi som tema. Norse följer en berättelse från mytologin vid namn Gudarnas skatter vars innehåll syftar till att två dvärgar ska tillverka tre skatter till gudarna. Berättelsen är hämtad från böckerna Nordens gudar och myter skriven av H R Ellis Davidson (1964/1984) samt Snorres Edda översatt av Björn Collinder (1970). Till detta huvuduppdrag tillkommer egenskrivna sidouppdrag.

 

Den frågeställning som ligger som grund för rapporten är:

 

  • Hur kan jag förmedla en bild av den nordiska mytologin genom mitt spel?
    • Vilken händelse lämpar sig för att gestalta mytologin?
    • Hur ska händelsen gestaltas?

 

Den första delfrågan behandlar alltså vad som ska berättas och den andra hur händelsen ska berättas.

 

För att besvara dessa frågor så används dels andra liknande spel; Rune (2000), Age of Mythology (2002) och World of Warcraft: Wrath of the Lich King (2008). Den litteratur som används är Game Design - Theory & Practice (Rouse III, 2005), Andrew Rollings and Ernest Adams on Game Design (Rollings & Adams, 2003), Nordisk mytologisk kosmologi som spelvärld - Vilka källor bör användas i skapandet av en spelvärld baserad på nordisk mytologi? (Nilsson, 2006) samt Fruktan, medkänsla och kritisk distans (Tjäder, 2000).

 

Huvudsakligen i Andrew Rollings and Ernest Adams on Game Design (Rollings & Adams, 2003) används Christopher Voglers The Hero’s Journey (1993, i Rollings & Adams, 2003) som definierar hur en berättelse är uppbyggd utifrån tolv steg.

 

Svar på första frågeställningen blev således historien Gudarnas skatter som återfinns i boken Nordens gudar och myter (Davidson, 1964/1984). Valet av just denna historia har bl.a. sin bakgrund i Aristoteles definitioner av ett drama.

 

Svar på andra frågeställningen med användandet av Voglers The Hero’s Journey (1993, i Rollings & Adams, 2003) resulterade i ett icke-linjärt strukturerat uppdrag som följer nio av de tolv steg som beskrivs. De resterande tre stegen används först och främst till längre spel som har en djupare bakgrundshistoria (Rollings & Adams, 2003).


Norse
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Marklund, Sanna, und Max Dyrhage. „Spel som rekryteringsverktyg inom IT“. Thesis, KTH, Skolan för datavetenskap och kommunikation (CSC), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-168969.

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Syftet med denna uppsats var att ta reda på var och hur ett spel kan användas i en rekryteringsprocess inom svenska IT-branschen. För att undersöka detta studerades rekryteringsprocessen för svenska företag inom IT-branschen, forskning och teorier om speldesign och samband mellan personlighetsdrag och spelbeteende. Kvalitativa intervjuer med rekryterare och spelforskare samt en undersökning över samband mellan personlighetsdrag och spelartyp har genomförts.   Undersökningen visar att ett spel bör anpassas efter var i rekryteringsprocessen man ämnar använda det. Det framkom två delar i rekryteringsprocessen där ett spel skulle kunna användas. Dels under insamlingen av kandidater till en rekryteringsprocess för att locka kandidater eller profilera företaget och dels för att bedöma en kandidats lämplighet, både vad gäller personlighet och kompetens, att arbeta inom IT. Den testgrupp som undersökts består till störst del av personer som tycker om att utforska i ett spel och undersökningen föreslår därmed att ett spel för att locka kandidater eller profilera företaget designas för att passa dem. Vad det gäller att bedöma lämplighet föreslår undersökningen att ett spel tillåter kandidaten att spela på olika sätt och utifrån spelarens beteende kan samband med olika personlighetsdrag påvisas.
The purpose of this study was to find out where and how a game can be used in the recruitment process within the IT industry. To investigate this studies were made of the recruitment process Swedish companies in the IT industry, research and theories of game design and the relationship between general personality traits and the gaming behavior. Qualitative interviews with recruiters and game researcher and a study of the relationship between personality traits and the game's personality has been implemented. This has been combined with the literature in recruitment and games to identify recommendations on the continuation of game design for a game aimed towards recruitment.The study shows that a game should be adjusted to where in the recruitment process you aim to use it. The study showed two parts od the recruitment process where a game could be in use, for one a game could fit in the collection of candidates for a recruitment process to attract candidates or brand the company and for second to assess a candidate's technical skills. The test group surveyed consists mostly of people who like to explore in a game and the study therefore proposes a game to attract candidates in a recruitment process should be designed. When it comes to assessing technical skills the study suggests a game the candidate can play in different ways. Based on the player's behavior different personality traits can be demonstrated.
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Wietek, Jonas [Verfasser], Hegemann [Gutachter] Peter, Bartl [Gutachter] Franz und J. Simon [Gutachter] Wiegert. „Anion Conducting Channelrhodopsins / Jonas Wietek ; Gutachter: Hegemann Peter, Bartl Franz, J. Simon Wiegert“. Berlin : Humboldt-Universität zu Berlin, 2018. http://d-nb.info/1185579125/34.

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Bartl, Jasmin [Verfasser], und Edna [Akademischer Betreuer] Grünblatt. „Impairment of insulin signaling pathway in Alzheimer’s disease / Jasmin Bartl. Betreuer: Edna Grünblatt“. Würzburg : Universitätsbibliothek der Universität Würzburg, 2012. http://d-nb.info/1029426759/34.

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Andrade, Simone Caixeta de 1977. „Investigação do papel da homeoproteína BARX1 na morfogênese do dente molar em camundongos“. [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/290038.

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Orientadores: Sergio Roberto Peres Line, Marcelo Rocha Marques
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba
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Resumo: A dentição não é somente o maior componente do complexo crânio facial dos mamíferos, mas um modelo útil de desenvolvimento, combinado em um sistema de um único órgão, onde ocorrem fenômenos de organização espacial, simetria, aquisição de formas complexas e citodiferenciação órgão-específica. Durante os primeiros estágios do desenvolvimento do dente ocorre uma série de interações entre o epitélio oral e mesênquima, por meio de diferentes moléculas sinalizadoras ao longo do futuro processo alveolar. Bmp4 atua ativando Msx1 na região de incisivos e molares e restringe a ação de Barx1 apenas na região dos molares. A interação entre o sinal mesenquimal Bmp4 e o sinal epitelial Shh faz parte dos primeiros eventos da formação do germe dentário no estágio botão. As fases seguintes são os estágios capuz e sino. Mutações nos genes Msx1 e Barx1 impedem o desenvolvimento do germe dentário além do estágio botão. Para o gene Msx1 essa condição é permanente, enquanto para Barx1 é temporal e o crescimento do germe dentário é retomado após o estágio E14.5 em camundongos. O objetivo desse trabalho é investigar a interação genética entre Msx1 e Barx1 no desenvolvimento do primeiro molar inferior na fase sino (E16.5) e qual a influência da ausência do gene Msx1 na dimensão das estruturas vestigiais MS, R2 e do primeiro molar inferior nas fases botão (E13.5) e sino (E16.5). Esse estudo também se propôs a avaliar se genes Barx2, Barhl1 e Barhl2 estariam expressos em botões de molares inferiores (E13.5). Os resultados indicaram que na ausência completa de Barx1, um único alelo de Msx1 não é suficiente para promover a evolução do botão dentário a capuz em camundongos E16.5 Barx1;Msx1 e não houve expressão de Bmp4 nesses camundongos. A expressão nula dos genes Barx2, Barhl1 e Barhl2 em botões de molares inferiores em camundongos wild-type E13.5 indica que genes da família Bar não possuem nenhum papel no desenvolvimento de molares inferiores. Ainda, dados alométricos de Msx1-/- (E13.5 e E16.5) indicam que a mutação no gene Msx1 e consequente ausência de expressão de Smad1-5-8 e Shh não impede o crescimento no sentido proximal-distal. Conclui-se que existe interação entre Barx1 e Msx1. Barx1 é necessário para controlar os níveis de expressão de Bmp4. Barx2 possivelmente desempenha um papel importante na morfogênese de pré-molares e incisivos inferiores. O atraso no desenvolvimento dos molares inferiores de camundongos Msx1-/- é permanente ao estágio botão, contudo, os botões dentários destes camundongos continuam a exibir um crescimento no sentido proximal-distal no estágio E16.5
Abstract: The dentition is not only the largest component of the craniofacial complex of mammals, but a useful model of development, combined in a single organ system, where phenomena of spatial organization, symmetry, complex shape acquisition and organ-specific cytodifferentiation occur. During the early stages of tooth development, series interactions take place between oral epithelial and mesenchyme by different signalling molecules along the future alveolar process. Bmp4 acts by activating Msx1 in the region of incisors and molars and it restricts the action of Barx1 only to the molars' region. The interaction between mesenchymal Bmp4 signal and Shh epithelial signal is part of the first events of tooth germ formation at the bud stage. The next stages are cap and bell. Mutations in Msx1 and Barx1 genes inhibit the development of the tooth germ beyond the bud stage. For the Msx1 gene, this condition is permanent, while for Barx1 is temporal and the growth of tooth germ is retaken after stage E14.5 in mice. This study investigates the genetic interaction between Msx1 and Barx1 in the first lower molar development at the bell stage (E16.5), the effect of the absence of Msx1 gene in the size of the vestigial structures MS, R2 and first lower molar bud (E13.5) and bell (E16.5). This study also aimed to assess whether Barx2, Barhl1 and Barhl2 genes were expressed in lower molars buds (E13.5). The results indicated that in the complete absence of Barx1, a single allele of Msx1 is not sufficient to promote the development of tooth bud to cap in E16.5 Barx1;Msx1 mice, and there was no expression of Bmp4 in these mice. The null expression of Barx2, Barhl1 and Barhl2 genes in lower molar buds in E13.5 wild-type mice indicates that genes of the Bar family do not exert any role in the development of lower molars. Still, allometric data on Msx1-/- (E13.5 and E16.5) indicates that Msx1 gene mutation and consequently the absence of Shh and SMAD1-5-8 expression do not prevent growth towards proximal-distal. It is concluded that there is interaction between Barx1 and Msx1. Barx1 is necessary to control the expression levels of Bmp4. Barx2 might play a role in the lower premolars and incisors morphogenesis. The delayed development of Msx1-/- lower molars is permanent at the bud stage, however, the tooth buds of these mice continue to exhibit growth towards proximal-distal at E16.5 stage
Doutorado
Histologia e Embriologia
Doutor em Biologia Buco-Dental
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46

Coursen, Jeffrey Thomas. „An experiment in joint product price optimization price elasticities and subsitution [sic] decisions of the hungry barfly /“. Connect to this title online, 2007. http://etd.lib.clemson.edu/documents/1202498978/.

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Lee, Cindy. „Analysis of two factors, BARD1 and MYCBP, that stimulate DNA double strand break repair“. The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429262304.

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Barel, Gal [Verfasser]. „Network Propagation with Node Core for Genotype-Phenotype Associations and Module Identification / Gal Barel“. Berlin : Freie Universität Berlin, 2021. http://d-nb.info/1228334633/34.

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49

Bartl, Michael [Verfasser]. „Untersuchungen zur neuromuskulären Pathophysiologie bei der Charcot-Marie-Tooth-Typ-1A-Erkrankung / Michael Bartl“. Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2021. http://d-nb.info/1234236184/34.

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50

Sakka, Emna. „Étude de l'oncogène BARF1 codé par le virus Epstein Barr : fonction mitogène et localisation“. Lyon 1, 2007. http://www.theses.fr/2007LYO10215.

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BARF-1, un oncogène du virus d'Epstein-Barr exprimé dans 90% des cancers nasopharyngés, a un pouvoir immoratalisant et transformant dans divers types cellulaires. Mon premier travail consiste à étudier l'effet et la localisation de la proteine p29 codée par BARF-1 après l'addition dans le milieu de culture de la lignée epithéliale humaine HaCaT. La proteine p29 possède une activité mitogène, entrainant une progression du cycle cellulaire de la phase G1 à S. L'expression de BARF1 dans HaCaT induit la formation tumorale chez la souris nude. L'analyse en microscopie électronique et confocale montre sa localisation cytoplasmique et nucléaire. Dans mon deuxième travail, l'effet transformant des mutants de délétions et substitutions de BARF-1 a été étudié dans les fibroblastes de souris Balb/c3T3. Les acides aminés situant entre 31 et 56ème semblent déterminants dans l'induction de la transformation
BARF1, an oncogene encoded by Epstein-Barr virus expressed in 90% of NPC, possess immortalizing and transforming activity in various cell types. We focus our first part of work to study the effect and localization of p29 protein encoded by BARF1 in human epithelial HaCaT culture medium. The p29 protein showed its mitogenic activity resulting in cell cycle progression G1 to S phase. Expression de BARF in HaCaT cells induced malignant transformation in nude mice. Confocal and immunoelectron mcroscopy analysis showed its cytoplasmic and nuclear localization. In the second part of work, the efect of deletion and substitution mutants of BARB-1 was studied in rodent fibroblast Balb/c3T3. Its amino acid sequence between 31 and 56th was responsible to malignant transformation
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