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Auswahl der wissenschaftlichen Literatur zum Thema „Application des DPI“
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Zeitschriftenartikel zum Thema "Application des DPI"
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Hülskötter, Kirsten, Fred Lühder, Alexander Flügel, Vanessa Herder und Wolfgang Baumgärtner. „Tamoxifen Application Is Associated with Transiently Increased Loss of Hippocampal Neurons following Virus Infection“. International Journal of Molecular Sciences 22, Nr. 16 (06.08.2021): 8486. http://dx.doi.org/10.3390/ijms22168486.
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Tamoxifen is frequently used in murine knockout systems with CreER/LoxP. Besides possible neuroprotective effects, tamoxifen is described as having a negative impact on adult neurogenesis. The present study investigated the effect of a high-dose tamoxifen application on Theiler’s murine encephalomyelitis virus (TMEV)-induced hippocampal damage. Two weeks after TMEV infection, 42% of the untreated TMEV-infected mice were affected by marked inflammation with neuronal loss, whereas 58% exhibited minor inflammation without neuronal loss. Irrespective of the presence of neuronal loss, untreated mice lacked TMEV antigen expression within the hippocampus at 14 days post-infection (dpi). Interestingly, tamoxifen application 0, 2 and 4, or 5, 7 and 9 dpi decelerated virus elimination and markedly increased neuronal loss to 94%, associated with increased reactive astrogliosis at 14 dpi. T cell infiltration, microgliosis and expression of water channels were similar within the inflammatory lesions, regardless of tamoxifen application. Applied at 0, 2 and 4 dpi, tamoxifen had a negative impact on the number of doublecortin (DCX)-positive cells within the dentate gyrus (DG) at 14 dpi, without a long-lasting effect on neuronal loss at 147 dpi. Thus, tamoxifen application during a TMEV infection is associated with transiently increased neuronal loss in the hippocampus, increased reactive astrogliosis and decreased neurogenesis in the DG.
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Meyer, M. D., und M. K. Hausbeck. „Using Soil-Applied Fungicides to Manage Phytophthora Crown and Root Rot on Summer Squash“. Plant Disease 97, Nr. 1 (Januar 2013): 107–12. http://dx.doi.org/10.1094/pdis-12-11-1071-re.
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Phytophthora crown and root rot (Phytophthora capsici) of summer squash is especially difficult to manage because all commercial cultivars are highly susceptible to P. capsici. Producers have traditionally relied on foliar fungicide applications to control Phytophthora crown and root rot despite their limited efficacy. Soil fungicide applications, including via subsurface drip chemigation, have recently gained interest as a method of improving control of P. capsici infections. In this study, soil drenches and foliar applications of 11 fungicides were compared for control of Phytophthora crown and root rot of summer squash in replicated field and greenhouse trials. Fungicides were applied at 7-day intervals. Incidence (%) of plant death was assessed from 7 to 42 days post inoculation (dpi) in field trials. Crown rot severity was rated on a scale of 1 (no wilting) to 5 (plant death) from 5 to 21 dpi in greenhouse trials. Results of field and greenhouse trials were similar. Plant death of ‘Cougar’ following inoculation with P. capsici isolate 12889 occurred at all growth stages from first true-leaf to full maturity in field trials. Plant death 42 dpi differed significantly (P ≤ 0.0001) among fungicides and application methods. The fungicide–application method interaction also was significant. Some fungicides were ineffective regardless of application method. In general, soil drenches were more effective than foliar applications at limiting plant death but no treatment completely controlled disease symptoms. Mean plant death 42 dpi was 41% for soil drenches and 92% for foliar sprays. Drenches of fluopicolide, mandipropamid, or dimethomorph limited plant death to ≤10% and prevented yield loss associated with root and crown rot. Foliar applications generally did not reduce plant death compared with the untreated, inoculated control, and were unable to prevent yield loss in field trials. In greenhouse trials, crown rot severity differed significantly (P ≤ 0.0001) among fungicides, application methods, and cultivars when plants were inoculated with P. capsici isolate 12889 or SP98. Crown rot was less severe and disease progress was slower following soil drenches than foliar applications. Some fungicide treatments were more effective on ‘Leopard,’ which was less susceptible to P. capsici than ‘Cougar.’ Soil application methods, including soil drench and drip chemigation, should be evaluated when fungicides are registered for soilborne disease control, because these methods provide better control of Phytophthora crown and root rot than foliar application.
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Suzuki, Hiroka, Noriyuki Hatano, Yukiko Muraki, Yuka Itoh, Satoko Kimura, Hidetoshi Hayashi, Kikuo Onozaki, Yoshiaki Ohi, Akira Haji und Katsuhiko Muraki. „The NADPH oxidase inhibitor diphenyleneiodonium activates the human TRPA1 nociceptor“. American Journal of Physiology-Cell Physiology 307, Nr. 4 (15.08.2014): C384—C394. http://dx.doi.org/10.1152/ajpcell.00182.2013.
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Transient receptor potential ankyrin 1 (TRPA1) is a Ca2+-permeable nonselective cation channel expressed in neuronal and nonneuronal cells and plays an important role in acute and inflammatory pain. Here, we show that an NADPH oxidase (NOX) inhibitor, diphenyleneiodonium (DPI), functions as a TRPA1 activator in human embryonic kidney cells expressing human TRPA1 (HEK-TRPA1) and in human fibroblast-like synoviocytes. Application of DPI at 0.03–10 μM induced a Ca2+ response in HEK-TRPA1 cells in a concentration-dependent manner. The Ca2+ response was effectively blocked by a selective TRPA1 antagonist, HC-030031 (HC). In contrast, DPI had no effect on HEK cells expressing TRPV1-V4 or TRPM8. Four other NOX inhibitors, apocynin (APO), VAS2870 (VAS), plumbagin, and 2-acetylphenothiazine, also induced a Ca2+ response in HEK-TRPA1 cells, which was inhibited by pretreatment with HC. In the presence of 5 mM glutathione, the Ca2+ response to DPI was effectively reduced. Moreover, mutation of cysteine 621 in TRPA1 substantially inhibited the DPI-induced Ca2+ response, while it did not inhibit the APO- and VAS-induced responses. The channel activity was induced by DPI in excised membrane patches with both outside-out and inside-out configurations. Internal application of neomycin significantly inhibited the DPI-induced inward currents. In inflammatory synoviocytes with TRPA1, DPI evoked a Ca2+ response that was sensitive to HC. In mice, intraplantar injection of DPI caused a pain-related response which was inhibited by preadministration with HC. Taken together, our findings demonstrate that DPI and other NOX inhibitors activate human TRPA1 without mediating NOX.
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Avram, Sorin, und Cristian Neanu. „Large-scale comparison between the diffraction-component precision indexes favors Cruickshank’s Rfree function“. Journal of the Serbian Chemical Society, Nr. 00 (2021): 76. http://dx.doi.org/10.2298/jsc200518076a.
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This study aims to provide a first large-scale comparison between the various diffraction-component precision index (DPI) equations, assess the applicability of the parameter, and make recommendations on DPI computation. The DPI estimates the average accuracy of the atomic coordinates obtained by the structural refinement of protein diffraction data, with application in crystallography and cheminformatics. Although, Cruickshank and Blow proposed DPI equations based on R and Rfree in order to calculate DPI values, which remain scarcely employed in the quality assessment of the Protein Data Base (PDB) files, due to the unclear data extraction protocols (to assign variables), the complex equations, the lack of extensive applicability studies and the limited access to automated computations. In order to address these shortcomings, the entire RCSB PDB database was evaluated using Cruickshank?s and Blow?s R and Rfree DPI variations. Computations of 143070 X-ray structures indicate that Rfree-based DPI equations apply to 30% more protein structures compared to R-based DPI equations, with Cruickshank Rfree-based DPI (CRF) exceeding the number of successful Blow?s Rfree-based DPI (BRF) computations. Although our results indicate that, in general, the resol-utions < 2 ? assure consistency among the various DPIs computations (differences <0.05 ?), we recommend the use of CRF DPI because of its wider applicability.
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Zendehdel Baher, Shalaleh, Shadi Yaqoubi, Kofi Asare-Addo, Hamed Hamishehkar und Ali Nokhodchi. „Dry Powder Formulation of Simvastatin Nanoparticles for Potential Application in Pulmonary Arterial Hypertension“. Pharmaceutics 14, Nr. 5 (20.04.2022): 895. http://dx.doi.org/10.3390/pharmaceutics14050895.
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It has been hypothesized that simvastatin could be used to treat pulmonary arterial hypertension (PAH). This study is intended to formulate a simvastatin nanoparticle dry powder inhalation (DPI) formulation. Simvastatin nanoparticles were prepared via an emulsification and homogenization-extrusion method, followed by spray drying of the colloidal suspension of simvastatin nanoparticles containing mannitol to get it into a respirable size. Particle size distribution, morphology, and crystallinity of the fabricated nanoparticles of the obtained microparticles for DPI formulation were assessed by dynamic light scattering (DLS), scanning electron microscopy (SEM), and X-ray diffraction pattern (XRPD), respectively. Aerosolization performance of the DPI formulation was assessed by the Next Generation Impactor (NGI) equipped with an Aerolizer®. Simvastatin nanoparticles were around 100 nm with a very narrow size distribution (PDI = 0.105). The X-ray diffraction pattern revealed that the crystallinity of simvastatin was decreased by the spray drying procedure. Microscopic images displayed that gathered nanoparticles were in the suitable inhalable range and had the appropriate shape and surface properties for pulmonary delivery. Aerosolization assessment by the NGI indicated a suitable inhalation performance (fine particle fraction of 20%). In conclusion, the results confirmed that the spray drying technique for simvastatin can be optimized to obtain simvastatin aggregated nanoparticles without any coarse carrier to be used in DPI formulation for better deposition of the drug in the lungs for local treatment of PAH.
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Walter, Johannes, Jannis Mende, Samuel Hutagalung, Obada T. Alhalabi, Martin Grutza, Guoli Zheng, Thomas Skutella, Andreas Unterberg, Klaus Zweckberger und Alexander Younsi. „The Single-Dose Application of Interleukin-4 Ameliorates Secondary Brain Damage in the Early Phase after Moderate Experimental Traumatic Brain Injury in Mice“. International Journal of Molecular Sciences 24, Nr. 16 (14.08.2023): 12756. http://dx.doi.org/10.3390/ijms241612756.
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Activation of the interleukin-4 (IL-4) pathway ameliorates secondary injury mechanisms after experimental traumatic brain injury (TBI); therefore, we assessed the effect of a therapeutic IL-4 administration on secondary brain damage after experimental TBI. We subjected 100 C57/Bl6 wildtype mice to controlled cortical impact (CCI) and administered IL-4 or a placebo control subcutaneously 15 min thereafter. Contusion volume (Nissl staining), neurological function (hole board, video open field, and CatWalkXT®), and the immune response (immunofluorescent staining) were analyzed up to 28 days post injury (dpi). Contusion volumes were significantly reduced after IL-4 treatment up to 14 dpi (e.g., 6.47 ± 0.41 mm3 vs. 3.80 ± 0.85 mm3, p = 0.011 3 dpi). Macrophage invasion and microglial response were significantly attenuated in the IL-4 group in the acute phase after CCI (e.g., 1.79 ± 0.15 Iba-1+/CD86+ cells/sROI vs. 1.06 ± 0.21 Iba-1/CD86+ cells/sROI, p = 0.030 in the penumbra 3 dpi), whereas we observed an increased neuroinflammation thereafter (e.g., mean GFAP intensity of 3296.04 ± 354.21 U vs. 6408.65 ± 999.54 U, p = 0.026 in the ipsilateral hippocampus 7 dpi). In terms of functional outcome, several gait parameters were improved in the acute phase following IL-4 treatment (e.g., a difference in max intensity of −7.58 ± 2.00 U vs. −2.71 ± 2.44 U, p = 0.041 3 dpi). In conclusion, the early single-dose administration of IL-4 significantly reduces secondary brain damage in the acute phase after experimental TBI in mice, which seems to be mediated by attenuation of macrophage and microglial invasion.
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Meyer, Michael D., und Mary K. Hausbeck. „Using Cultural Practices and Cultivar Resistance to Manage Phytophthora Crown Rot on Summer Squash“. HortScience 47, Nr. 8 (August 2012): 1080–84. http://dx.doi.org/10.21273/hortsci.47.8.1080.
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The effects of bed height, mulches, composted poultry litter, and cultivars on Phytophthora crown rot, caused by Phytophthora capsici Leonian, of summer squash (Cucurbita pepo L.) were evaluated in the absence of fungicide applications. The experimental design was a split-split-split plot arrangement of a randomized complete block. Bed height (flat or raised) was the main plot treatment. Mulches (bare soil, wheat straw, or plastic) were subplot treatments. Composted poultry litter applications (0 or 4.5 t·ha−1) were sub-subplot treatments. Squash cultivars (Cougar or Payroll) were sub-sub-subplot treatments. Incidence of plant death (%) was assessed from 0 to 35 days post-inoculation (dpi) with P. capsici. Plant death 35 dpi and area under the disease progress curve (AUDPC)differed significantly (P < 0.0001) between the cultivars Cougar and Payroll. Mean plant death 35 dpi was 87% for ‘Payroll’ and 99% for ‘Cougar’. The bed height × cultivar interaction was also significant (P = 0.0018) in the analyses of variance for plant death and AUDPC. Plant death at 35 dpi and AUDPC for ‘Payroll’ were greater in flat beds than raised beds. Disease was unaffected by the main effects of bed height, mulch type, or application of poultry litter. Thirty-two summer squash cultivars and 10 germplasm accessions were also evaluated for resistance to Phytophthora crown rot in a separate greenhouse trial. Crown rot severity was rated on a 1 (no symptoms) to 5 (plant death) scale at 18 dpi. Crown rot severity differed significantly (P < 0.0001) among cultivars and germplasm accessions. Crown rot severity averaged 4.3 on commercial cultivars and 2.2 on germplasm accessions. Crown rot was least severe on the commercial cultivar Spineless Beauty (mean rating = 2.9). No disease developed on four accessions of Cucurbita moschata previously reported to be crown rot-resistant.
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Tian, Yufei, Yang Liu, Qiuyuan Wang, Jie Wen, Yiru Wu, Jianwei Han und Chaolai Man. „Stress-Induced Immunosuppression Affects Immune Response to Newcastle Disease Virus Vaccine via Circulating miRNAs“. Animals 12, Nr. 18 (12.09.2022): 2376. http://dx.doi.org/10.3390/ani12182376.
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Studies have shown that circulating microRNAs (miRNAs) are important players in the immune response and stress-induced immunosuppression. However, the function and mechanism of stress-induced immunosuppression affecting the immune response to the Newcastle disease virus (NDV) vaccine remain largely unknown. This study analyzed the changes of 15 NDV-related circulating miRNAs at different immune stages by qRT-PCR, aiming to explore the key timepoints, potential biomarkers, and mechanisms for the functional regulation of candidate circulating miRNAs under immunosuppressed conditions. The results showed that stress-induced immunosuppression induced differential expressions of the candidate circulating miRNAs, especially at 2 days post immunization (dpi), 14 dpi, and 28 dpi. In addition, stress-induced immunosuppression significantly affected the immune response to NDV vaccine, which was manifested by significant changes in candidate circulating miRNAs at 2 dpi, 5 dpi, and 21 dpi. The featured expressions of candidate circulating miRNAs indicated their potential application as biomarkers in immunity and immunosuppression. Bioinformatics analysis revealed that the candidate circulating miRNAs possibly regulated immune function through key targeted genes, such as Mg2+/Mn2+-dependent 1A (PPM1A) and Nemo-like kinase (NLK), in the MAPK signaling pathway. This study provides a theoretical reference for studying the function and mechanism of circulating miRNAs in immune regulation.
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Zhou, En-min, Jose Riva und Alfonso Clavijo. „Development of an Immunoglobulin M (IgM) Capture Enzyme-Linked Immunosorbent Assay for Detection of Equine and Swine IgM Antibodies to Vesicular Stomatitis Virus“. Clinical Diagnostic Laboratory Immunology 8, Nr. 3 (01.05.2001): 475–81. http://dx.doi.org/10.1128/cdli.8.3.475-481.2001.
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ABSTRACT An immunoglobulin M (IgM) capture enzyme-linked immunosorbent assay (MC-ELISA) was developed for the detection of primary infection of vesicular stomatitis virus (VSV) in equine and swine sera. The test was based on the use of biotinylated sheep antibodies against equine or swine IgM molecules bound to a streptavidin-coated ELISA plate. The captured IgM antibodies were detected by application of antigens prepared from the New Jersey and the Indiana VSV serotypes (VSV-NJ and VSV-IN, respectively) and mouse polyclonal antibodies against VSV-NJ and VSV-IN. The MC-ELISA was compared to a competitive ELISA (C-ELISA) and the standard microtiter serum neutralization (MTSN) assay by testing serum samples from horses and pigs experimentally infected with VSV-NJ or VSV-IN. The MC-ELISA detected specific homologous IgM antibodies from equine and swine sera as early as 5 and 4 days postinfection (DPI), respectively, and as late as 35 DPI. The MTSN test also detected antibodies as early as 5 DPI and as late as 160 DPI. In a similar fashion, the C-ELISA detected antibodies from 6 to 7 DPI and as late as 160 DPI. These results demonstrated that the MC-ELISA is a useful test for serodiagnosis of primary VSV infection in horses and pigs.
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Spadoti, Leila Maria, José Raimundo Ferreira Dornellas und Salvador Massaguer Roig. „Proteolysis of prato type cheese produced using ultrafiltration“. Scientia Agricola 62, Nr. 3 (Juni 2005): 235–39. http://dx.doi.org/10.1590/s0103-90162005000300006.
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The application of milk ultrafiltration technology for cheese manufacture presents several advantages. However, it also influences proteolysis and, consequently, cheese ripening. The effects of five different processing methods for Prato cheese were evaluated with respect to the time evolution of the extent and depth of proteolysis indexes (EPI and DPI). The following treatments (T) for cheese production were studied: T1 - without ultrafiltration (standard); T2, T3, T4 and T5 - using milk concentrated by ultrafiltration (UFCM) and respectively: T2 - without pre-fermentation of the UFCM; T3 - pre-fermentation of 10% of the UFCM; T4 - pre-fermentation of 20% of the UFCM, and T5 - pre-fermentation of 20% of the UFCM plus indirect heating. Treatments affected the EPI and DPI of the cheeses (T1 lower values for EPI and DPI and T4 higher values for EPI and DPI). The time influenced the extent and depth of proteolysis indexes.
Dissertationen zum Thema "Application des DPI"
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Kyrylenko, Anastasiia. „L’exportation des normes de propriété intellectuelle par l’UE vers les pays voisins de l’Europe de l’Est“. Electronic Thesis or Diss., Strasbourg, 2022. http://www.theses.fr/2022STRAA008.
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Dans cette thèse, j'ai abordé les dispositions d'application des droits de propriété intellectuelle de trois accords d'association (AA), que l'Union européenne (UE) a conclus avec la Géorgie, la Moldavie et l'Ukraine au début des années 2010. J'ai puisé dans ces AA en tant que représentants de la politique extérieure souvent critiquée de l'UE en matière de propriété intellectuelle (PI), lancée en 2004, qui consiste à exporter les règles internes de l'UE en matière de propriété intellectuelle par le biais d'accords commerciaux. Cette analyse m'a permis d'aborder la question fondamentale de cette thèse : y a-t-il quelque chose de bon dans les accords commerciaux de l'UE ? La réponse claire, appuyée par cette thèse sur l'exemple des AA, est « oui ». L'enquête générale, qui a conduit à ces conclusions, était triple. Premièrement, j'ai analysé la politique générale de l'UE envers la Géorgie, la Moldavie et l'Ukraine concernant l'application des droits de propriété intellectuelle, ainsi que sa perception dans la littérature académique. Deuxièmement, après avoir retracé les critiques académiques existantes sur les accords commerciaux de l'UE, j'ai examiné si ces critiques étaient justifiées, telles qu'appliquées aux trois AA. Troisièmement, sur la base de cette analyse, j'ai identifié des problèmes supplémentaires auxquels les pays tiers pourraient être confrontés lors de la mise en oeuvre d'un accord commercial avec l'UEIn this thesis, I have addressed the IPR enforcement provisions of three Association Agreements (AAs), which the European Union (EU) concluded with Georgia, Moldova and Ukraine in the early 2010s. I drew on these AAs as representatives of the EU's often criticized external intellectual property (IP) policy, launched in 2004, which consists of exporting the EU's internal IP rules through trade agreements. Said analysis allowed me to approach the fundamental question of this thesis: is there something good with the EU trade agreements? The plain answer, supported by this thesis on the example of the AAs, is “yes”. The general investigation, which led to these conclusions, was threefold. First, I analyzed the general policy of the EU towards Georgia, Moldova and Ukraine regarding the enforcement of IPRs, as well as its perception in the academic literature. Second, after tracing existing academic criticism of the EU's trade agreements, I examined whether such criticism was justified, as applied to the three AAs. Third, based on this analysis, I identified additional problems that third countries might face when implementing a trade agreement with the EU
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Morrison, Matthew Arthur. „Theory, Synthesis, and Application of Adiabatic and Reversible Logic Circuits For Security Applications“. Scholar Commons, 2013. https://scholarcommons.usf.edu/etd/5082.
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Programmable reversible logic is emerging as a prospective logic design style for implementation in modern nanotechnology and quantum computing with minimal impact on circuit heat generation. Adiabatic logic is a design methodology for reversible logic in CMOS where the current flow through the circuit is controlled such that the energy dissipation due to switching and capacitor dissipation is minimized. Recent advances in reversible logic using and quantum computer algorithms allow for improved computer architectures. Production of cost-effective Secure Integrated Chips, such as Smart Cards, requires hardware designers to consider tradeoffs in size, security, and power consumption. In order to design successful security-centric designs, the low-level hardware must contain built-in protection mechanisms to supplement cryptographic algorithms such as AES and Triple DES by preventing side channel attacks, such as Differential Power Analysis (DPA). Dynamic logic obfuscates the output waveforms and the circuit operation, reducing the effectiveness of the DPA attack. Significant research exists in the design and analysis of locally optimal adiabatic elements towards mitigation of side channel attacks. However, none of these works have addressed the use of adiabatic logic in implementation of flexible and programmable hardware security policies. Nor has adiabatic logic been employed in hardware security applications such as trustworthy voting systems and data encryption standards.
In this dissertation, I address theory, synthesis, and application of adiabatic and reversible logic circuits for security applications. First, two major debates in reversible computing are addressed. These debates must be addressed in order to devise computational logic primitives in
any emerging quantum computing technology. First, we address whether charged based computing is limited due to the use of charge as a state variable. We propose the use of body biasing in CMOS adiabatic systems as a design methodology for reducing the need for gradually changing the energy barriers. Simulation results in HSPICE at 22nm are presented which show behavior of a source-memory device operating at sub-Landauer operation. Second, we address whether reversible logic can be used to design sequential computing structures, such as memory devices. we present an analysis of Quantum Turing Machines with sequential reversible logic structures, to show that the entropy gain is substantially less than the Landauer Barrier of kTln(2), which is the limiting factor for irreversible computing. A mathematical proof is presented showing bit erasure does not occur in sequential reversible logic structures, and that these devices are physically reversible as long as appropriate delay elements are inserted in the feedback paths to prevent race conditions. This proof validates implementation of sequential reversible logic towards ultra-low power computing.
Next, a novel algorithm for synthesis of adiabatic circuits in CMOS is proposed. This approach is unique because it correlates the offsets in the permutation matrix to the transistors required for synthesis, instead of determining an equivalent circuit and substituting a previously synthesized circuit from a library. Parallelism is used, and the bijective properties of the device to achieve synthesis of the logic structure in O(n) time. Then, using the ESPRESSO heuristic for minimization of Boolean functions method on each output node in parallel, we optimize the synthesized circuit. It is demonstrated that the algorithm produces a 32.86% improvement over previously synthesized circuit benchmarks.
For stronger mitigation of DPA attacks, we propose the implementation of Adiabatic Dynamic Differential Logic for applications in secure IC design. Such an approach is effective in reducing power consumption, demonstrated using HSPICE simulations with 22nm predictive technology. The benefits of our design are demonstrated by comparing instantaneous power waveforms and observing the magnitude of differential power spikes during switching events. First, simulation results for body-biasing on sub-threshold adiabatic inverters show an improvement in differential power up to 43.28% for similar inverters without body biasing. Then, a High Performance Adiabatic Dynamic Differential Logic (PADDL) is presented for an implementation in high frequency secure ICs. This method improves the differential power over previous dynamic and differential logic methods by up to 89.65%. Finally, we propose a Body-Biased Adiabatic Dynamic Differential Logic (BADDL) for ultra-low power applications. Simulation results show that the differential power was improved upon by a factor of 199.16.
Then, we present an adiabatic S-box which significantly reduces energy imbalance compared to previous benchmarks. The design is capable of forward encryption and reverse decryption with minimal overhead, allowing for efficient hardware reuse.
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Ramirez, Ivette, und David Mauricio. „DPF: App for diagnosing the psychological profile of a possible feminicide“. Institute of Electrical and Electronics Engineers Inc, 2020. http://hdl.handle.net/10757/656632.
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El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.The most visible expression of violence against women is feminicide. The majority of feminicide cases are committed by the partner or former partner of the victim. This involves ongoing domestic abuses, threats or intimidation, sexual violence or situations in which women have less energy or resources than their partner. In addition, clinics, public hospitals or private health institutes have mental health evaluation processes, however, these flows are usually carried out in several sessions, which causes a delay in the diagnosis. In this article, a mobile application that supports psychologists or psychiatrists during the process of the psychological profile diagnosis is proposed. The system contains a questionnaire and psychological tests, in this way, based on the patient responses, indicators, and metrics, the psychological profile of the assailant is obtained as a result. The use of the system in 40 patients shows that the selection times and the psychological test qualification have improved, as well as the interpretation of the results and the total process of diagnosis, which, when obtained at opportune time, allows specialists to prevent the victim from a possible feminicide.
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Vainigli, Lorenzo. „Un'applicazione Android per la gestione ed il monitoraggio dei flussi monetari personali“. Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/13262/.
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Tenere traccia delle proprie entrate e delle proprie uscite monetarie può risultare molto utile se si vogliono avere degli indicatori sulla qualità della gestione del proprio denaro.
In questo testo viene presentata un'applicazione per dispositivi Android con la quale l'utente può salvare tutti i suoi movimenti monetari, con la possibilità di condividerli con altri utenti e di effettuare previsioni su eventi futuri.
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Yu, Haiming. „Analog ASICs for a Depth of Interaction (DOI) Positron Emission Tomography (PET) dectector module /“. Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/6066.
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Zhu, Yitao. „bec: l’applicazione mobile per monitoraggio della sicurezza dei dipendenti“. Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2019.
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BEC è un sistema sviluppato per la gestione della sicurezza del dipendente durante lo svolgimento del lavoro.
Oltre il principale compito di monitoraggio, il sistema cerca di migliorare l'esperienza lavorativa dei dipendenti all'interno dell'azienda attraverso l'utilizzo delle nuove tecnologie.
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ALBERTI, STEFANO. „Synthesis, characterization, optimization and application of TiO2-based photocatalytic materials for environmental applications related to emerging pollution“. Doctoral thesis, Università degli studi di Genova, 2020. http://hdl.handle.net/11567/999751.
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This PhD thesis deals with the exploitation of heterogeneous photocatalysis, as an Advanced Oxidation Process, for environmental issues related to the emerging pollution: in particular for wastewater remediation and bacterial decontamination purposes. During this project, several photocatalytic materials have been synthesized by coupling semiconductor (TiO2) nanoparticles (both bare and doped) to different supporting materials, e.g. persistent luminescence materials (3ZnO:Ga2O3:2GeO2: Cr3+; CaAl2O4: (La, Nd)3+), magnetic and porous materials (ferrite nanoparticles, magnetic zeolite obtained from industrial waste) and polymeric materials (based on polydimethylsiloxane “PDMS”). In addition, an analytical approach to the study on the abatement and the quantification of emerging pollutants was considered, an important part of which was carried out at the Water Lab of the Environmental Engineering Department at Technical University of Crete, under the supervision of Professor Elia Psillakis.
Specifically, TiO2 was synthesized through the sol-gel technique, both in the undoped and doped form (for example with Cu and N), while its crystallization on several supporting materials was obtained with different synthetic techniques such as: sol-gel synthesis, solid-state synthesis, hydrothermal/solvothermal synthesis and electrospinning technique. Some of the synthesized materials were investigated using a chemometric approach, that is the possibility to exploit an Experimental Design mathematical model in order to investigate the optimal synthetic conditions to get enhanced photocatalytic efficiency (within the experimental domain) for the materials.
All samples synthesized within the current project were subjected to a physical-chemical characterization, by means of: X-Ray Diffraction “XRD” and crystallographic refinements (Rietveld, Pair Distribution Function “PDF”, Williamson-Hall plot), Scanning and Transmission Electron Microscopy-Energy Dispersive X-Ray Spectrometry “SEM-EDS”, “TEM”, Porosimetry Brunauer-Emmett-Teller “BET”, Dynamic Light Scattering “DLS”, Differential Scanning Calorimetry “DSC”, Diffuse Reflectance (Kubelka-Munk plots for Energy Gap “Eg”), Rheological Measurements, Luminescence Properties, Turbidimetry, Inductively Coupled Plasma – Atomic Emission Spectroscopy “ICP-AES”, Diffuse Reflectance Infrared Fourier Transform Spectroscopy “DRIFTS” and antibacterial properties with E. Coli cultures. Above all, a kinetic characterization in terms of photocatalytic efficiency evaluation was always performed for synthesized samples. In particular, kinetic behaviour of the photocatalysts was evaluated by means of Methylene Blue “MB” aqueous solutions degradation, studied as a function of time, with different initial concentrations (as required by ISO NORM 10678:2010). For MB quantification, a UV-Vis spectrophotometer was used, and experiments were usually performed in triplicate. Furthermore, during the first part of the project, a Pilot Plant Prototype was assembled (with a processing volume equal to 1L) and used for preliminary evaluations on a potential industrial scale-up. All tests and characterizations achieved were adapted according to the specific supporting material employed.
Eventually, considering the nature of emerging micro-pollutants, an analytical approach to the determination of their concentration in aqueous systems was employed. Specifically, chromatographic tests were performed with liquid and gas chromatography techniques, often coupled with mass spectrometry, for some specific emerging pollutants (Ofloxacin, Parabens, Nicotine, Salbutamol). Matrix effects were also considered in the evaluation of the pollutants’ degradation during the advanced oxidation tests.
This task wouldn’t have been possible without valuable National and International collaborations, which gave an essential help to the development of the project for what concerns a part of the reported characterization. My acknowledgements are directed to: Department of Chemistry and Industrial Chemistry - University of Genova (Analytical, Industrial, Physical Sections), Analytic and Photochemistry Section of the Department of Chemistry - University of Pavia; Department of Chemistry - University of Kuwait; Department of Environmental Engineering - Technical University of Crete; Institute of Methodologies of Environmental Analysis, Institute of Matter and Institute of Superconducting and other Innovative Materials and Devices - National Research Council.
Each individual contribute will be highlighted in each dedicated section, throughout the manuscript.
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Prota, Lucia. „Design and characterization of DPI (dry powder inhaler) for the pulmonary delivery of anti-inflammatory and antibiotic drugs in the treatment of cystic fibrosis disease“. Doctoral thesis, Universita degli studi di Salerno, 2012. http://hdl.handle.net/10556/600.
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2010 - 2011The aim of the present PhD project was to design inhalable powder-based formulations for pharmaceutical products that may improve the treatment of pulmonary diseases, mainly cystic fibrosis, and may be easier for patients to use. Particularly, the present project aims to supply CF patients with flavonoids (Naringin) and aminoglycosides (Gentamicin sulfate) in a respirable form as a valid alternative over more conventional (oral or parenteral) anti-inflammatory and antibiotic therapy. As a matter of fact, in CF epithelial cells, antioxidant defense systems appear to be defective in their ability to control the amount of ROS produced and over abundance of ROS may cause tissue injury-events and modify intracellular signalling pathways leading to enhanced inflammatory processes, typical of CF airways. Overall, evidence suggests improved CFTR function in vitro when flavonoids, such as genistein, are used. For chronic Pseudomonas aeruginosa (Pa) infections in CF, gentamicin given by pulmonary route may plays important role. In fact, it was observed daily inhalation of some aminoglycosides from nebulized solution delays the acquisition of chronic Pa infections and decreases CF progression. The project address a number of the key features that are outstanding in inhaled delivery, mainly - characteristic of the active drug; - properties of the drug formulation, particularly powder flow, particle size, shape, surface properties and drug/carrier interaction; - consistent dose delivery and high proportion of dose getting to the lung; - performance of the inhaler device, including aerosol generation and delivery. A balance among these characteristics is necessary in the design of a drug formulation intended for pulmonary administration. Utilizing proven (Spray-drying) or innovative (Supercritical Assisted Atomization) technology, stable and micronized powders usefull for dry powder inhaler (DPI) production have been developed. Moreover, the research has been based on in vitro product test methods to evaluate the health effects of produced powders and their aerodynamic behaviour through the pulmonary system. Optimized stability and bioavailability of the selected drugs, the achieving of therapeutically effective concentrations for the pulmonary care of cystic fibrosis have been other goals of the research. Technologies and products that the research is aimed to develop would be of interest to a number of pharmaceutical companies either in the respiratory area or trying to get a toehold in this market. Specific objectives of this research have been: design and development of Dry Powder Inhalers (DPIs) containing flavonoids (Naringin) or aminoglycoside antibiotics (Gentamicin sulfate) micronized powder by spray drying production or by Supercritical Assisted Atomization (SAA); optimization of the aerodynamic characteristics of the powders, through the use of excipients (amino acids) not toxic for lung but able to improve the powder flow properties and dispersion which, in turn, may increase lung deposition of the drugs; in vitro evaluation of the biological activity of the engineered particles on a model of bronchial epithelial cell lines from patients with cystic fibrosis (CuFi1, F508del/F508del CFTR), in comparison to the activity of the same products on normal bronchial epithelial cell lines (NuLi1). (edited by author)
X n.s.
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Corno, Camilla <1988>. „"Farmaci in Cina: regolamentazione e sistema di controllo dei prezzi."“. Master's Degree Thesis, Università Ca' Foscari Venezia, 2013. http://hdl.handle.net/10579/2714.
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Con una proiezione di crescita annuale del 20 per cento, il settore farmaceutico in Cina appare destinato a superare il Giappone quale seconda maggiore potenza del settore entro il 2015.Tuttavia, sebbene la percentuale della spesa sanitaria sul Pil totale sia attualmente soltanto di circa un 5 per cento, ciò che preoccupa è che quasi un 50 per cento di questa è dovuto alle spese in medicinali. Per questo motivo negli ultimi anni, il Governo è impegnato a riformare il sistema, attraverso normative e regolamentazioni volte al controllo e al monitoraggio dei prezzi. Gli effetti di questi interventi governativi, tuttavia, per una serie di ragioni, risultano essere ancora poco soddisfacenti ed è necessario pensare a delle strategie alternative per limitare la spesa medica che va a pesare sulle spalle dei singoli pazienti.
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Tumino, Andrea. „Progettazione di un applicativo web-based per il backup dei dati di Google Drive“. Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/17653/.
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Descrizione di un'applicazione web che offre un servizio di backup del proprio Google Drive, sia completo che personalizzato.
Nella tesi vengono spiegati i requisiti, l'architettura e il funzionamento del software, approfondendo le tecnologie utilizzate per lo sviluppo e le difficoltà riscontrate.
Bücher zum Thema "Application des DPI"
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Simon, Perkins, und National Computing Centre, Hrsg. The DIP applications handbook. Oxford: NCCBlackwell, 1991.
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1964-, Xu Xiangyang, und Xiao Rongshi, Hrsg. Ji guang xian dai zhi zao ji shu. Beijing Shi: Guo fang gong ye chu ban she, 2007.
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Xian dai jun yong guang xue ji shu. Beijing: Ke xue chu ban she, 2003.
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Zotti, Valeria, und Ana Pano Alaman, Hrsg. Informatica umanistica. Florence: Firenze University Press, 2017. http://dx.doi.org/10.36253/978-88-6453-546-3.
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Da una prospettiva di grande attualità scientifica e didattica, il volume si inserisce all’interno delle odierne riflessioni teorico-metodologiche sull’informatica umanistica e sulle digital humanities, affrontando diversi aspetti dell’applicazione delle tecnologie digitali allo studio della lingua dell’arte. I contributi, nati dal progetto di ricerca Lessico multilingue dei Beni Culturali, condotto dall’Università di Firenze in collaborazione con altre università italiane e straniere, descrivono numerose risorse e piattaforme online di comunicazione, organizzazione e condivisione di applicativi e di dati, estremamente utili per gli studiosi del lessico e della traduzione specializzata in più lingue, in particolare nell’ambito del patrimonio culturale e artistico.
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G, Nassetti, Timellini G, ENEA (Agency :. Italy) und Centro ceramico (Bologna Italy), Hrsg. Raggi infrarossi e microonde nell'essiccamento dei prodotti ceramici. Bologna: Ed. Int. Centro Ceramico, 1990.
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Pasokonjuku, Ojisan. Yū yū jiteki 50-dai kara no pasokon nyūmon /cho, Ojisan Pasokonjuku. Tōkyō: Kinnokuwagata-sha, 2000.
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Baroni, Francesco. La guerra dei radar: Il suicidio dell'Italia : 1935/1943. Milano: Greco & Greco, 2007.
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Rossi, Monica, und Federica Ottone, Hrsg. Teorie e sperimentalismo progettuale per la ricerca in tecnologia dell’architettura / Theories and experimental design for research in architectural technology. Florence: Firenze University Press, 2013. http://dx.doi.org/10.36253/978-88-6655-406-6.
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Il volume, che raccoglie riflessioni intorno al tema della città, intesa come campo di sperimentazione, traccia un panorama aggiornato della ricerca dottorale e post-dottorale in Tecnologia dell’Architettura, da cui traspare la volontà di offrire spunti teorici di ampio respiro e, contemporaneamente, testimoniare una vasta gamma di applicazioni specialistiche. Nell’approccio ambientale, che accoglie i suggerimenti dei territori valorizzandone la "cultura materiale", appare il tratto comune sul quale sono impostate molte delle tematiche di ricerca qui esposte. The book, that gathers reflections on the theme of the city, intended as field of experimentation, gives an updated panorama of the doctoral (PhD) and postdoctoral research in Architectural Technology, and offers ample theoretical insights as well as a large collection of specialized applications. The environmental approach, that welcomes suggestions from the surrounding areas, highlighting the "material culture", shows the common traits that are present in many of the research themes here exposed.
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Dai zhe iPhone qu lü xing. Taibei Shi: Dian nao ren wen hua, 2013.
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Buzzanca, Giuseppe. Musica e intelligenza artificiale: Per un modello connessionista di mente musicale, teoria dei linguaggi formali, reti neurali artificiali e relative applicazioni in informatica musicale. Bari: Florestano edizioni, 2016.
Den vollen Inhalt der Quelle findenBuchteile zum Thema "Application des DPI"
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Yang, Fang, und Zhi-qun Zhang. „Research of Application Protocol Identification System Based DPI and DFI“. In Recent Advances in Computer Science and Information Engineering, 305–10. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-25769-8_44.
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Zhong, Zhimin, Yuliang Zhang, Guanglong Yang und Yongping Kong. „GPU-Based Parallel Processing Technology in DPI“. In Web Technologies and Applications, 44–53. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-28121-6_5.
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Acs, Zoltan J. „The Digital Platform Economy and the Entrepreneurial State: A European Dilemma“. In International Studies in Entrepreneurship, 317–44. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-94273-1_17.
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AbstractThe application of big data, new algorithms, and cloud computing is creating a digital platform economy (DPE) built around platform organizations and their platform-based ecosystem. We use the DPE Index to examine Europe’s digital efficiency across countries and explain its global position by analyzing Brexit and the electric vehicle industry. We argue that the United Kingdom left the European Union because E.U. regulations were holding back the U.K.’s strong DPE and that a weak DPE is holding German back from being a leader in the electric vehicle industry. The problem for Europe’s DPE is that the entrepreneurial state is strong and the private sector is weak.
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Park, Tae-Jun, Mun-Kyu Lee, Dowon Hong und Kyoil Chung. „A DPA Countermeasure by Randomized Frobenius Decomposition“. In Information Security Applications, 271–82. Berlin, Heidelberg: Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/11604938_21.
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Karasavvas, Konstantinos, Mario Antonioletti, Malcolm Atkinson, Neil Chue Hong, Tom Sugden, Alastair Hume, Mike Jackson, Amrey Krause und Charaka Palansuriya. „Introduction to OGSA-DAI Services“. In Scientific Applications of Grid Computing, 1–12. Berlin, Heidelberg: Springer Berlin Heidelberg, 2005. http://dx.doi.org/10.1007/11423287_1.
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Shin, Jong Hoon, Dong Jin Park und Pil Joong Lee. „DPA Attack on the Improved Ha-Moon Algorithm“. In Information Security Applications, 283–91. Berlin, Heidelberg: Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/11604938_22.
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Gallina, Viola, Barna Gal, Ádám Szaller, Daniel Bachlechner, Elisabeth Ilie-Zudor und Wilfried Sihn. „Reducing Remanufacturing Uncertainties with the Digital Product Passport“. In Lecture Notes in Mechanical Engineering, 60–67. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-28839-5_7.
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AbstractIn contrast to the linear production model, the circular economy aims to close the loop of materials. One part of this approach is remanufacturing, which extends the lifetime of products. Various stakeholders in the supply chain are involved in remanufacturing. This makes the management and optimization of remanufacturing activities complex. The data required for optimization is often missing, which leads to uncertainties. A new European Commission initiative, the digital product passport (DPP), is believed to facilitate information exchange in the supply chain and cloud be a good solution to reduce uncertainties. The primary purpose of this paper is the quantification and evaluation of the advantages of the DPP. Based on real industrial data, a discrete event simulation model of a remanufacturing system with three production lines was developed. The authors suppose the hypothetical existence of a DPP and illustrate the benefits arising from its application.
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Oeming, Manfred. „Intelligentia Dei: Artificial Intelligence, Human Reason and Divine Wisdom“. In Intelligence - Theories and Applications, 351–68. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-04198-3_21.
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Clark, Keith, Peter J. Robinson und Richard Hagen. „Programming Internet Based DAI Applications in Qu-Prolog“. In Multi-Agent Systems. Theories, Languages and Applications, 137–51. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/10693067_10.
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Fischer, Klaus, Jörg P. Müller und Markus Pischel. „A Testbed for the Development of DAI Applications“. In Informatik aktuell, 179–90. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-79267-0_17.
Der volle Inhalt der QuelleKonferenzberichte zum Thema "Application des DPI"
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Li, Yunchun, und Jingxuan Li. „MultiClassifier: A combination of DPI and ML for application-layer classification in SDN“. In 2014 2nd International Conference on Systems and Informatics (ICSAI). IEEE, 2014. http://dx.doi.org/10.1109/icsai.2014.7009372.
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Kim, Eun Joo, Yool Kwon und Young Boo Kim. „A method for providing seamless on-demand application service using DPI in IP network“. In 2011 6th International Conference on Broadband and Biomedical Communications (IB2Com). IEEE, 2011. http://dx.doi.org/10.1109/ib2com.2011.6217890.
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Tasheva, Rumiana. „APPLICATION OF AN INCLINOMETER IN THE FUNCTIONAL DIAGNOSIS OF CHILDREN SPORTING FOOTBALL“. In INTERNATIONAL SCIENTIFIC CONGRESS “APPLIED SPORTS SCIENCES”. Scientific Publishing House NSA Press, 2022. http://dx.doi.org/10.37393/icass2022/157.
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ABSTRACT The aim of the study was to apply for the first time in Bulgaria a Digital Pelvic Inclinometer in the functional diagnostic of children playing football. Material and methods. During the period March-August 2020, 107 boys aged 6-10 years (mean age 8.63 ±.115) from soccer clubs Baroko, Vitosha 13, Talant, Tsarsko Selo were assessed. Players train an average of 1.91 ±0.866 years with a frequency of 2.70 ±0.461 times a week. All children were tested for pelvic inclination using a Digital Pelvic Inclinometer (DPI) based on Sub-4 Technologies. Pelvic angle data is calculated electronically and digitally displayed on an LCD. The anterior superior iliac spine (ASIS) and posterior superior iliac spine (PSIS) levels were measured bilaterally and the difference between the two values was determined as pelvic torsion. Results: Data were analyzed with SPSS 25.0. Pearson’s coefficient demonstrates a correlation of 0.813 between the in-clinometer data on the left and right. There is also a 0.357 correlation between the inclinometer data on pelvic torsion and the isometric test for static strength endurance of the lower paravertebral muscles. Test of Normality Koplmogorov-Smirnov shows other than normal distribution – on the left 0,101 (Sig. .013) and on the right 0,134 (Sig. .000). These results determine applying of the nonparametric test Kruskal Wallis. The data demonstrate statistically significant differences between teams, in the inclinometer on the right x2=7.86 (Sig. .049) and pelvis torsio x2=10.506 (Sig. .015). In addition also the data of the pelvis torsio shows statistically significant differences between groups according to age (first 6-7, second 8-9, and third 10-11 years) x2=8.432 (Sig. .015). Conclusion: The application of Digital Pelvic Inclinometer provides an accurate diagnosis of pelvic inclination and the presence of torsion, which is essential for the timely treatment of functional dysfunctions and for the prevention of complications.
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Versteeg, Henk K., und Ricky D. Wildman. „An Optical Method for the Study of Aerosol Generation in Dry Powder Inhalers“. In ASME 7th Biennial Conference on Engineering Systems Design and Analysis. ASMEDC, 2004. http://dx.doi.org/10.1115/esda2004-58174.
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Dry powder inhalers (DPIs) are portable, breath-actuated devices used for respiratory drug delivery. They have been the subject of intense research and development activity over the last 15 years, however, no systematic study of the effects of geometry on aerosol generation in DPIs has been reported in the literature. In particular, the first stage process — powder fluidisation — has hardly been studied in the context of DPI applications. The short time scales and the complexities of the air/powder interactions during the conversion of a powder bed into an aerosol present a challenging environment for experimental study. This paper reports an optical technique for the study of powder fluidisation inside a simplified, optically transparent DPI metering chamber geometry. We describe a system based on digital image analysis of high-speed video recordings of the transient powder-airflow interactions. Using diffuse backlighting we have generated black-on-white images of the interaction of frictional, cohesionless particles with an air jet flow. Image-processing techniques were subsequently applied to determine several aspects of the time-dependent properties that describe the development of the bed during the aeration of the powder. The paper concludes by pointing out how the proposed method could be used to improve understanding of the limitations associated with current DPI metering chamber configurations and help forward design of improved DPIs.
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Lin, Yen-Liang, und Fan-gang Tseng. „A 2D Chamber-Free Micro Droplet Generator Array Controlled by Dynamic Virtual Walls“. In ASME 2009 Second International Conference on Micro/Nanoscale Heat and Mass Transfer. ASMEDC, 2009. http://dx.doi.org/10.1115/mnhmt2009-18441.
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This paper presents an innovative micro droplet generator array controlled by dynamic virtual walls. The heaters for bubble generation can be arranged into a dense two-dimensional (2D) array by removing the chamber wall structures. The micro droplet generator array was fabricated by heater lithography and direct nozzle formation on a laminated SU-8 dry film without any solid chamber wall among heaters. With precise time-delayed control among microheaters, droplets could be ejected out by the thrust generated from the bubbles around the ejection site under the specific configuration. The volume of the droplet was about 3.8 pL and the initial speed can approach 15 m/s, meeting the standard of commercial printheads. In addition, we carried out the meniscus control by precise sequential control of bubble generations, so the micro droplet generator is free of satellite droplets throughout the whole traveling distance. It showed that the meniscus undergoes a “push-pull-push” progress which can effectively cut the liquid column short. To summarize, a 330 dpi chamber-free micro droplet generator prototype has been realized, and it has the potential for the application to large 2D format, high frequency, high resolution printing.
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Noteboom, Jan Willem. „Generator Retaining Rings: In Situ Inspection and Life Assessment“. In ASME 2009 Power Conference. ASMEDC, 2009. http://dx.doi.org/10.1115/power2009-81072.
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Stress corrosion cracking (SCC) in retaining rings of generators has been a major issue since large generator manufactures started to advise generator owners to replace and inspect retaining rings made from certain materials in the mid 1990’s. KEMA has been inspecting generator retaining rings with automated systems from the seventies on. Since 1995 new developments led to the possibility of also testing rings in situ, eliminating the need of removing the rotor from the stator and thus saving considerable down-time. Over the years, step by step improvements to the system and its application to generator retaining ring inspections have been implemented, one of which is the use of smaller probes and manipulators. Another improvement is the implementation of eddy current testing (ECT) to increase the detection capability for cracking at the outside surface in parallel to the automated ultrasonic testing (AUT). Experience obtained with this method contradicts some of the common ideas about reliability of other Non-destructive testing (NDT) methods, in particular the application of Dye Penetrant inspection (DPI) which appears to be less reliable. By performing fracture mechanics calculations to evaluate detected and sized flaw indications, predictions of remaining life of the rings can be made (Fitness-for-Purpose analysis). This paper presents results of applying the in situ retaining ring inspection system in the last 14 years and gives an overview of cases — some of those from recent inspections — where defect indications were detected, sized and evaluated. In some cases this resulted in recommendations to replace the retaining rings.
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Chen, Wei, und Chenhao Yuan. „A Probabilistic-Based Design Model for Achieving Flexibility in Design“. In ASME 1997 Design Engineering Technical Conferences. American Society of Mechanical Engineers, 1997. http://dx.doi.org/10.1115/detc97/dtm-3882.
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Abstract In the early stages of product development, the transformation between design requirements and design solutions often involves uncertainties when specifying the desired target value for the performance expressed in design requirements. Additionally, to provide flexibility for later development, the design solution obtained is desired to be a range rather than a single solution. Our primary focus in this paper is on developing a probabilistic-based design model as a basis for providing the flexibility that allows designs to be readily adapted to changing conditions. This is obtained by developing a range of design solutions which meet a ranged set of design requirements. Meanwhile, designers are allowed to specify the varying degree of desirability of a ranged set of design requirements based on their preferences. The Design Preference Index (DPI) is introduced as a design metric to measure the goodness of flexible designs. Providing the foundation to our work are the probabilistic representations of design performance, the application of robust design concept, and the utilization of the compromise Decision Support Problem (DSP) as a multi-objective decision model. A two-bar structural design is used as an example to demonstrate our approach. Our focus in this paper is on introducing the probabilistic-based design model and not on the results of the example problem, per se.
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Boya, Vinay Kumar, Anoop Adhyapak, Vineetha Komma und Manoranjan Sahoo. „Automotive EMC Analysis of Touch Sensing IC“. In Symposium on International Automotive Technology. 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 2024. http://dx.doi.org/10.4271/2024-26-0353.
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<div class="section abstract"><div class="htmlview paragraph">The technology in the automotive industry is evolving rapidly in recent times. Thus, with the development of new technologies, the challenges are also ever-increasing from an Electromagnetic Interference and Susceptibility (EMI/EMC) perspective. A lot of the latest technologies in Adaptive Driver Assistance Systems (ADAS), which include Rear Drive Assist, Blind Spot Detection (BSD), Lane Change Assist (LCA) to name a few, and other features like Anti-Braking System (ABS), Emergency Brake Assist (EBD) etc. rely heavily on different types of sensors and their detection circuitry. In addition, a lot of other internal functions in the Engine Control Unit (ECU) also depend on such sensors’ functionalities. Thus, it becomes imperative to study the potential impact of higher field emissions on the immunity behaviour of the sensors. In this paper, we will study the immunity behaviour of such an automotive capacitive touch-sensing integrated circuit (IC) and its impact on the application of the same. A Direct Power Injection (DPI) test is conducted on the IC and the immunity behaviour is extracted by simulation methodology. In order to enhance the overall immunity performance in a practical application, a reference design board is developed, and the immunity performance is measured by the Bulk Current Injection (BCI) technique. In addition, the measured BCI test results are simulated and validated based on the extracted immunity behaviour of the IC. This study shows that the immunity performance of the sensors’ circuitry can be effectively predicted by a simulation-based approach, thereby allowing system engineers to utilize this approach in early design stages to predict possible immunity EMI/EMC test failures and make necessary changes in design to avoid multiple PCB design and EMI/EMC testing iterations.</div></div>
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Chen, Jian, Chiyi He, Xuhua Wang, Yi Liu und Lei Yu. „Cost-Effective D-DPF Design of Aftertreatment System for Non-Road Mobile Machinery China Stage IV“. In WCX SAE World Congress Experience. 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 2024. http://dx.doi.org/10.4271/2024-01-2136.
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<div class="section abstract"><div class="htmlview paragraph">Since Non-Road Mobile Machinery (NRMM) China stage IV legislation has been implemented from 2022, some engines within maximum rated power between 37 to 560 kW are required for gaseous emissions, particulate matter (PM) and particulate number (PN) control, evaluated over testing cycle of Non-Road Transient Cycle (NRTC) and Non-Road Steady Cycle (NRSC). The pollutants from diesel engines, widely used in NRMM applications, can be controlled using aftertreatment systems which are comprised of a diesel oxidation catalyst (DOC) and a diesel particulate filter (DPF), or optionally a selective catalytic reduction (SCR). In this paper, a compact D-DPF design is introduced and discussed on application in harvesters, tractors, and forklifts. Because harvesters have higher exhaust gas temperature than other applications, more passive regeneration behaviors were observed. Subsequently, a compact design of DOC catalyst on DPF (D-DPF) was studied, in other words is to coat DOC catalyst on DPF. For a diesel engine with 3.6 litter(L) displacement application, the total length of D-DPF was shortened around 15% compared to the conventional design of a DOC and a downstream DPF. Meantime, D-DPF design also has higher gaseous emission conversion rate for CO and hydrocarbons (HCs) at high temperature range. The soot loadings can be balanced in the D-DPF system for long time during real operating condition for harvesters’ machinery. By fuel injection upstream of D-DPF, the temperature in the middle of D-DPF can reach 600 °C to actively regenerate the DPF. This type of design of D-DPF is proved to be a very cost-effective solution for NRMM China stage IV application with real operation condition and relevant testing data.</div></div>
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Hedrick, John C., und Steven G. Fritz. „Partial Flow DPF System for Large Bore or High Power Applications“. In ASME 2014 Internal Combustion Engine Division Fall Technical Conference. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/icef2014-5493.
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A number of technical challenges are faced when applying wall flow Diesel Particulate Filter (DPF) systems to large high horsepower off-highway applications, locomotives, and marine diesel engine applications due to the size of the DPF system required and the space constraints associated with these applications. Experimental results show that a new approach of adding an exhaust bypass valve, creating a partial-flow DPF system, can greatly reduce the DPF package size while continuing to offer significant PM emission reductions. The exhaust bypass valve is configured to open proportionally to maintain a pre-set maximum engine backpressure as the exhaust flow increases. Proof-of-concept testing of an experimental partial flow DPF system was conducted on a 3MW, 4-stroke locomotive engine, following U.S. EPA locomotive certification test protocols. These tests showed that the experimental DPF system, which was approximately 40 percent smaller than what would be expected for this application, provided an 84 percent PM reduction over the US-EPA Switcher Cycle and 59 percent reduction over the Line-Haul Cycle. It was calculated that the system could provide a 91 percent PM reduction over the Switcher Cycle and 76 percent PM reduction over the Line-Haul Cycle with addition of a DOC in the bypass exhaust flow.
Berichte der Organisationen zum Thema "Application des DPI"
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Paillart, Maxence, Herman de Beukelaer und Gerald Schennink. Application of dynamic packaging to fresh-cut produce : Fresh on Demand - DP7. Wageningen: Wageningen Food & Biobased Research, 2023. http://dx.doi.org/10.18174/638330.
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2
PIERSON, KENDALL H., GARTH M. REESE, MANOJ K. BHARDWAJ, TIMOTHY F. WALSH und DAVID M. DAY. Experiences with FETI-DP in a Production Level Finite Element Application. Office of Scientific and Technical Information (OSTI), Mai 2002. http://dx.doi.org/10.2172/800966.
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3
Jelinek, Raz, Paul Dawson, Timothy Hanks, William Pennington und Julie Northcutt. Bacterial sensors for food processing environments. United States Department of Agriculture, Januar 2013. http://dx.doi.org/10.32747/2013.7598157.bard.
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The overall objective of this project was to develop a new bacterial contaminant sensor based upon polydiacetylene(PDA) which is a unique polymer that changes color and configuration in response to external molecular stimuli. While this polymer has been well studied and has been shown to respond to bacterial stimuli in the laboratory, application to food processing environments has not been demonstrated. One hurdle in the application of biosensors in a food processing environment is interference of food sanitizers with the detection of bacteria. Common food sanitizers were evaluated for their response to PDA and different concentrations paving the way for use of modified PDAs developed by the research team to be used in food plants. Further development of PDA bacterial sensors focused on simplifying its application by immobilizing PDA on cotton and paper for use on swabs, wipes and dip papers. Increasing the sensitivity of PDAs was investigated by attaching fluorophores. Future and continued work will include the decoration of PDAs with apatmers to improve the specificity of the biosensor to food pathogens.
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Badia, R., J. Ejarque, S. Böhm, C. Soriano und R. Rossi. D4.4 API and runtime (complete with documentation and basic unit testing) for IO employing fast local storage. Scipedia, 2021. http://dx.doi.org/10.23967/exaqute.2021.9.001.
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This deliverable presents the activities performed on the ExaQUte project task 4.5 Development of interface to fast local storage. The activities have been focused in two aspects: reduction of the storage space used by applications and design and implementation of an interface that optimizes the use of fast local storage by MPI simulations involved in the project applications. In the rst case, for one of the environments involved in the project (PyCOMPSs) the default behavior is to keep all intermediate les until the end of the execution, in case these les are reused later by any additional task. In the case of the other environment (HyperLoom), all les are deleted by default. To unify these two behaviours, the calls \delete object" and \detele le"have been added to the API and a ag \keep" that can be set to true to keep the les and objects that maybe needed later on. We are reporting results on the optimization of the storage needed by a small case of the project application that reduces the storage needed from 25GB to 350MB. The second focus has been on the de nition of an interface that enables the optimization of the use of local storage disk. This optimization focuses on MPI simulations that may be executed across multiple nodes. The added annotation enables to de ne access patters of the processes in the MPI simulations, with the objective of giving hints to the runtime of where to allocate the di erent MPI processes and reduce the data transfers, as well as the storage usage.
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Bowlin, Elizabeth, Puneet Agarwal und Rhett Dotson. PR-201-153718-R02 Integrity Assessment of DTI Pipelines Using High Resolution NDE. Chantilly, Virginia: Pipeline Research Council International, Inc. (PRCI), April 2018. http://dx.doi.org/10.55274/r0011480.
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This is a new revision of the Year 2 work. The NDE-3-2 project seeks to advance the state of the art for integrity assessment of difficult to inspect pipelines by proposing guidance for application of alternate inspection approaches other than hydrostatic test, in-line inspection and ECDA/ICDA currently prescribed by Code and Regulations. The hydrostatic test and in-line inspection methods for integrity assessment have in common the concept that the full length of the pipeline is assessed. Many pipelines exhibit configuration and operational issues that preclude integrity assessment by the prescribed methods. The ECDA/ICDA structured processes employ evaluation of protective barriers followed by deployment of a small sample of high resolution wall thickness measurements. The NDE-3-2 study proposes a new structured process that evaluates low resolution NDE data of the pipe wall for the full length of the pipeline followed by statistically significant numbers of high resolution wall thickness measurements to predict the condition of the pipeline relative to the fitness for service criterion of corroded pipe such as prescribed in ASME B31G. While conventional ILI inspections or hydrotest rely on full coverage as the basis for evaluating the integrity of a pipeline segment, this structured process would seek to use partial inspections at discrete locations and then use Extreme Value Analysis to estimate the integrity of pipeline segments. The objective is not to provide guidance to replace ILI or hydrostatic testing but rather to offer an alternative for the purposes of gathering data to justify the safe prioritization of piggability conversion or pipeline replacement of difficult to inspect pipelines for both onshore and subsea. This report documents the current state-of-the-art for corrosion location NDE, selection models, and Extreme Value Analysis (EVA) Methodologies for deployment in a structured process as an Alternative to In-Line Inspection of difficult to inspect pipelines. The research on NDE screening technologies addressed in this report reviews technologies identified in the Year 1 work that can be used to screen the condition of pipe wall along its full length as well as existing location selection models such as employed by Direct Assessment Methodologies. This report leverages extensive research that has been conducted on existing Extreme Value Analysis Methodologies from multiple sources and applications including metal corrosion (HOIS, HSE), pipeline corrosion, metocean criteria, wind loading, and multiple textbooks. Multiple case studies are summarized in this report that demonstrate the use of the Partial Inspection Integrity Assessment process utilizing EVA on segments of a pipeline compared to results from full length integrity assessments (either ILI or hydrotest). This report also documents a full Extreme Value Analysis using a demonstration case study and then compares the EVA results with the wall thickness measurements from a full length integrity assessment as a validation example. Ultimately, it is the goal of NDE-3-2 to identify more case studies that might serve as demonstrations. The report also identifies gaps that currently exist and the work that must be completed to develop a complete validated structured process required to deploy the technologies for integrity assessment of difficult to inspect pipelines. The research also aims to compare predictions of remaining life using statistical approaches applied to the partial inspection data with remaining life obtained from conventional integrity assessment using ILI or hydrostatic test.
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Arango, R. A., S. T. Lebow, V. Yang, S. L. Zelinka, P. K. Lebow und P. DeWald. Evaluation of moldicidal additives for wood preservatives used in dip-treatment of wood packaging materials for military applications. Madison, WI: U.S. Department of Agriculture, Forest Service, Forest Products Laboratory, 2022. http://dx.doi.org/10.2737/fpl-rp-715.
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Donahue, Jennifer, Jonathan Stewart, Nicolas Gregor und Yousef Bozorgnia. Ground-Motion Directivity Modeling for Seismic Hazard Applications. Pacific Earthquake Engineering Research Center, University of California, Berkeley, CA, April 2019. http://dx.doi.org/10.55461/gphh9609.
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We reviewed five models for modifying the natural log mean and within-event standard deviation of ground-motion models (GMMs) to account for directivity effects in the near-fault environment. We found broad consistency for strike–slip ruptures, with positive and negative directivity effects for cases of rupture towards and away from a site of interest, respectively. We found substantial divergence among directivity models for reverse slip, with some providing maximum directivity for sites positioned to experience the peak alignment of rupture direction with the fault-slip direction (this occurs in the up–dip direction), while others optimize directivity based on the amount of fault rupture towards the site (even if the azimuth of rupture propagation does not align with the fault-slip direction). We found four of five NGA-West2 GMMs to be centered on a condition of null directivity. Therefore, we consider those GMMs suitable for use in combination with similarly centered directivity models. We present two deterministic methods for adjusting ground-motion hazard results for the effects of directivity: one modifies ground motions for a specified hazard level based on location-specific (relative to fault) changes in mean and standard deviation; and the second produces a directivity-compatible conditional mean spectra. We also provide recommendations for incorporating directivity effects into calculations within the hazard integral by either (1) modifying the mean and standard deviation of ground motion to approximately account for the effect of variable hypocenter location; (2) integrating over a location-specific distribution of the directivity parameter, which also indirectly accounts for variable hypocenter location; or (3) integrating directly over alternate hypocenter locations. Review Panel: Jonathan D. Bray, Stephen A. Mahin, I. M. Idriss, Robert W. Graves and Tom Shantz.
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Ma, Juming, Fan Xu und Hongjun Li. A meta-analysis on the application of diffusion tensor imaging（DTI） in the diagnosis of HIV-associated neurocognitive disorders（HAND）. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, Oktober 2021. http://dx.doi.org/10.37766/inplasy2021.10.0079.
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Hodges. PR-364-09601-R02 Investigation into High Pressure DP Transmitter Calibration. Chantilly, Virginia: Pipeline Research Council International, Inc. (PRCI), März 2012. http://dx.doi.org/10.55274/r0010760.
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In many applications within the oil and gas industries, and in particular in the measurement of flow, differential pressure transmitters must operate with high accuracy and repeatability. The uncertainty of the measurement of flow varies proportionately to the uncertainty associated with the differential pressure measurement. There are many issues that arise from using differential type meters, and many of these issues are attributable to the differential pressure measurement. Issues such as turndown, linearity, repeatability, hysteresis and others are all important aspects of the differential pressure measurement. To ensure proper differential pressure measurement the oil and gas industry currently requires differential meters to be �calibrated� in the field. Several studies have shown that there are serious issues involved with performing that calibration in the field. The overall purpose of the Pipeline Research Council International, Incs (PRCI) investigation is to determine what these issues are, and how these issues can best be addressed. This is the unblinded version of the report.
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Hodges. PR-364-09601-R01 Investigation into High Pressure DP Transmitter Calibration. Chantilly, Virginia: Pipeline Research Council International, Inc. (PRCI), Oktober 2012. http://dx.doi.org/10.55274/r0010001.
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In many applications within the oil and gas industries, and in particular in the measurement of flow, differential pressure transmitters must operate with high accuracy and repeatability. The uncertainty of the measurement of flow varies proportionately to the uncertainty associated with the differential pressure measurement. There are many issues that arise from using differential type meters, and many of these issues are attributable to the differential pressure measurement. Issues such as turndown, linearity, repeatability, hysteresis and others are all important aspects of the differential pressure measurement. To ensure proper differential pressure measurement the oil and gas industry currently requires differential meters to be �calibrated� in the field. Several studies have shown that there are serious issues involved with performing that calibration in the field. This overall purpose of the Pipeline Research Council International, Inc�s (PRCI) investigation is to determine what these issues are, and how these issues can best be addressed. PRCI has contracted Colorado Engineering Experiment Station Inc. (CEESI) to perform the investigation. The investigation consisted of two milestones, a literature review and laboratory work. The literature review covered applicable industry standards, papers, articles, and manufacturer�s specifications. The results of the literature review are included in this report. The second milestone is the laboratory work. This work was performed at the CEESI facility in Colorado during 2011. The results are included in this report.