Zeitschriftenartikel zum Thema „Anti-oxidation protection“
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1
Zhao, Wei, Bo Zhu und Wei Wei Cao. „Preparation and Properties of Pyrolytic Carbon Coating on Carbon Materials Used in Czochraski Single Crystal Silicon Furnace“. Applied Mechanics and Materials 597 (Juli 2014): 170–74. http://dx.doi.org/10.4028/www.scientific.net/amm.597.170.
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In this paper, resin and vapor deposition (CVD) pyrolytic carbon coating on carbon materials was designed based on the oxidation erosion and silicification corrosion mechanism. Meanwhile the phase structure, microstructure, anti-oxidation and anti-silicification corrosion mechanisms of both coatings were studied. The surface of resin pyrolytic carbon coating has a lot of defec comparing with CVD pyrolytic carbon coating. After static oxidation test at 900 °C, the resin pyrolytic carbon coating haves some antioxidant protection ability, but after 4 h of static oxidation, weight loss rate is still as high as 30%. Antioxidant effect of CVD pyrolytic carbon coating is good, 4 h oxidation weightlessness rate is about 10%. After silicification corrosion at 1600 °C, CVD pyrolytic carbon has excellent silicification protection ability.
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Wang, Li, Jie-qing Li, Ji Zhang, Zhi-min Li, Hong-gao Liu und Yuan-zhong Wang. „Traditional uses, chemical components and pharmacological activities of the genus Ganoderma P. Karst.: a review“. RSC Advances 10, Nr. 69 (2020): 42084–97. http://dx.doi.org/10.1039/d0ra07219b.
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In recent years, some natural products isolated from the fungus of the genus Ganoderma have been found to have anti-tumor, liver protection, anti-inflammatory, immune regulation, anti-oxidation, anti-viral, anti-hyperglycemic and anti-hyperlipidemic effects.
3
Monika, Monika, und Jarosław Frydrych. „Olej ochronny o niskiej lepkości do czasowej ochrony elementów metalowych przed korozją“. Nafta-Gaz 76, Nr. 11 (November 2020): 864–69. http://dx.doi.org/10.18668/ng.2020.11.12.
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Corrosion of metals is the gradual destruction of metal under the impact of environmental factors. Chemical or electrochemical processes on the surface of the metal cause irreversible changes in the structure of the metal. To prevent this, during storage or transport, the surfaces of metal elements must be protected against environmental factors, which include: high air humidity, acid rain and variable temperature. These factors accelerate the corrosion process, which cannot be eliminated, but can be reduced by protecting metal elements with e.g. protective oils. Some metals have the ability to passivate, which is a natural protective agent that prevents corrosion. It consists in the formation of an oxide of this metal on the metal surface. Where there is no natural protection against corrosion, protective measures must be used. This paper presents the technology for the production of protective oil for temporary protection against corrosion. The innovation of this project is that the oil will form a thin, well adhering protective layer on the metal surface, which can be easily removed. It is characterised by very low viscosity and low dripping time. It is possible to achieve by using proper base oil with carefully selected anti-corrosion additives. Based on the standard PN-75/C-04154 Petroleum products. Rust protection by metal preservatives the humidity cabinet test method, corrosion tests were carried out. The paper presents the results of a humidity cabinet test for an oil mixture based on deeply refined base oil and properly selected refining additives. The test results confirmed very good anti-corrosive properties of the developed oil due to the use of a corrosion inhibitor and an oxidation inhibitor. The thickness of the protective layer formed on the metal surface was calculated based on a mathematical formula. The resulting layer forms a thin oil film, easy to remove and protecting the metal surface from corrosion.
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Yang, Zhehan, Yi Pan, Hengyu Zhao, Xiangmin Yang, Ying Liang, Zhen Zhang und Bin Fang. „Facile fabrication and low-temperature bonding of Cu@Sn–Bi core–shell particles for conductive pastes“. RSC Advances 11, Nr. 42 (2021): 26408–14. http://dx.doi.org/10.1039/d1ra02514g.
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Cu@Sn–Bi core–shell particles were synthesized and used as conductive fillers of ink applied to flexible printed circuits. This work provides new insights into the low-temperature bonding and anti-oxidation protection of Cu-based conductive pastes.
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Ji, Yu Bin, Peng Tian, Qi Chang Dai, Si Ting Wang und Ning Chen. „The Present Research Situation of Crinum asiaticum Alkaloids Active Ingredient“. Applied Mechanics and Materials 411-414 (September 2013): 3181–86. http://dx.doi.org/10.4028/www.scientific.net/amm.411-414.3181.
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The basic structures of Crinum Asiaticum alkaloids are N-(3, 4-dioxo-benzyl)-4-O-phenylethylamine, pyrrole phenanthridine, 5,10b-ethanophenanthridine. The basic framework can form a new parent nucleus structure with significant pharmacological activity by oxidation, dehydrogenation, cyclization, O, N-methylation, acylation reaction. Crinum Asiaticum alkaloids antibacterial, antimalarial, anti-inflammatory, anti-cancer, inducing tumor cell apoptosis, the protection of the cardiovascular and other effects are reviewed.
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Kim, Jung-In, Min-Jae Kim, Ha-Gyeong Jo, Da-Eun Jeong, Hye-Jin Park und Young-je Cho. „Anti-oxidation, anti-inflammation, anti-wrinkle, and pore-tightening effects of phenolic compounds from Aeonium sedifolium leaves“. Korean Journal of Food Preservation 30, Nr. 2 (April 2023): 347–57. http://dx.doi.org/10.11002/kjfp.2023.30.2.347.
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The succulent plant Aeonium sedifolium leaves contain several compounds that are of interest for their cosmetic uses on the skin. This study measured the inhibitory effects of enzyme production and antioxidant, astringent effects and skin wrinkles using Aeonium sedifolium leaves (ASL). The total phenolics compounds (TPC) content of ASL under optimal extraction conditions was 34.49 mg/g for hot water extract (ASLW) and 61.64 mg/g for 50% ethanol extract (ASLE). The ASLW and ASLE extracts were freeze-dried, powdered, and used as solids. TPC content, 2,2-diphenyl-1-picrylhydrazy (DPPH) radical scavenging activity, and 2,2’-azinobis (3-ethylben-zothiazoline 6-sulfonate) (ABTS) radical inhibition of the ASL phenolics were tested. The DPPH radical scavenging activities of ASLW and ASLE were tested at a TPC of 100 μg/mL. ABTS radical inhibition showed antioxidant activity of 100.00% in ASLW and ASLE, and the antioxidant protection factor of ASLW and ASLE was 1.07 and 1.22, respectively. The thiobarbituric acid-reactive substance (TBARS) inhibitory activity of ASLW and ASLE was 77.00%. The elastase inhibitory activity of ASLE was 69.03%, and collagenase inhibition activity for ASLW and ASLE was 29.82% and 54.76%, respectively. The astringent effect of ASLE was 89.82% at a TPC of 200 μg/mL. Thus, we concluded that ASL has the potential as a functional cosmetic ingredient with anti-aging effects on the skin.
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Lv, Xin, Linshui Zhou und Liying Xu. „Therapeutic and Clinical Nursing Values of Momordica charantia Extracts Combined with Hedyotis diffusa on Lung Cancer“. Journal of Biobased Materials and Bioenergy 16, Nr. 5 (01.10.2022): 760–64. http://dx.doi.org/10.1166/jbmb.2022.2220.
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The separation and identification of bioactive substances that come from natural resources have aroused increasing attention. Momordica charantia (M. charantia) has a variety of bio-activities, containing anti-oxidation, immune regulation, anti-tumor, radiation protection, anti-diabetes, and liver protection. After the extraction new substances from Momordica charantia, their treatment effect on lung cancer combined with Hedyotis diffusa was determined and the related mechanism was explored as well in this study. Firstly, the CCK-8 assay was conducted and the inhibition of the new substances combined with Hedyotis diffusa. Next, the real time RT-PCR was conducted and the relative expression of the VEGF in the cancer cells was determined. In addition, the complete chloroplast genome sequence of M. charantia is followed by the phylogenetic analysis.
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Lv, Xin, Linshui Zhou und Liying Xu. „Therapeutic and Clinical Nursing Values of Momordica charantia Extracts Combined with Hedyotis diffusa on Lung Cancer“. Journal of Biobased Materials and Bioenergy 17, Nr. 3 (01.06.2023): 345–49. http://dx.doi.org/10.1166/jbmb.2023.2259.
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The separation and identification of bioactive substances that come from natural resources have aroused increasing attention. Momordica charantia (M. charantia) has a variety of bio-activities, containing anti-oxidation, immune regulation, anti-tumor, radiation protection, anti-diabetes, and liver protection. After the extraction new substances from Momordica charantia, their treatment effect on lung cancer combined with Hedyotis diffusa was determined and the related mechanism was explored as well in this study. Firstly, the CCK-8 assay was conducted and the inhibition of the new substances combined with Hedyotis diffusa. Next, the real time RT-PCR was conducted and the relative expression of the VEGF in the cancer cells was determined. In addition, the complete chloroplast genome sequence of M. charantia is followed by the phylogenetic analysis.
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Zhang, Xu, Tao Fu, Kunkun Cui, Yingyi Zhang, Fuqiang Shen, Jie Wang, Laihao Yu und Haobo Mao. „The Protection, Challenge, and Prospect of Anti-Oxidation Coating on the Surface of Niobium Alloy“. Coatings 11, Nr. 7 (22.06.2021): 742. http://dx.doi.org/10.3390/coatings11070742.
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Niobium (Nb)-based alloys have been extensively used in the aerospace field owing to their excellent high-temperature mechanical properties. However, the inferior oxidation resistance severely limits the application of Nb-based alloys in a high-temperature, oxygen-enriched environment. Related scholars have extensively studied the oxidation protection of niobium alloy and pointed out that surface coating technology is ideal for solving this problem. Based on the different preparation methods of Nb-based alloys’ surface coatings, this article summarizes the relevant research of domestic and foreign scholars in the past 30 years, including the slurry sintering method (SS), suspension plasma spraying method (SPS), and halide activated pack cementation method (HAPC), etc. The growth mechanism and micromorphology of the coatings access by different preparation methods are evaluated. In addition, the advantages and disadvantages of various coating oxidation characteristics and coating preparation approaches are summarized. Finally, the coating’s oxidation behavior and failure mechanism are summarized and analyzed, aiming to provide valuable research references in related fields.
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Kanpipit, Nattawadee, Natsajee Nualkaew und Suthasinee Thapphasaraphong. „The Potential of Purple Waxy Corn Cob (Zea mays L.) Extract Loaded-Sericin Hydrogel for Anti-Hyperpigmentation, UV Protection and Anti-Aging Properties as Topical Product Applications“. Pharmaceuticals 16, Nr. 1 (27.12.2022): 35. http://dx.doi.org/10.3390/ph16010035.
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Sericin-hydrogel formulations incorporating purple waxy corn (Zea mays L.) cob extract (PWCC) were developed as potential topical skin cosmetic products. Sericin has wound healing properties, protects against ultraviolet (UV) radiation, and exhibits anti-inflammatory, anti-oxidation, and anti-tyrosinase activities. PWCC is a rich source of anthocyanins with antioxidants, UV protective, anti-inflammatory, and collagen-enhancing activities. Six hydrogel formulations (S1–S6) were investigated for anti-melanogenesis on the B16F10 melanoma cell line and UV-protection on human keratinocytes (HaCaT) and anti-aging activities on normal human dermal fibroblasts (NHDFs). The results showed that the hydrogel formulations enhanced the anthocyanin permeation through the skin. The S4 formulation indicated the highest inhibition of tyrosinase activity and reduced the melanin pigment, increased the cell viability of the UV-induced HaCaT cells, the inhibition of collagenase and elastase, and increased the collagen type I production without cytotoxicity. Therefore, the PWCC loaded-sericin hydrogels show a high potential as a novel anti-hyperpigmentation, UV protection, and anti-aging products for topical applications.
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Angeletti, Andrea, Maurizio Bruschi, Xuliana Kajana, Sonia Spinelli, Enrico Verrina, Francesca Lugani, Gialuca Caridi et al. „Mechanisms Limiting Renal Tissue Protection and Repair in Glomerulonephritis“. International Journal of Molecular Sciences 24, Nr. 9 (05.05.2023): 8318. http://dx.doi.org/10.3390/ijms24098318.
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Glomerulonephritis are renal disorders resulting from different pathogenic mechanisms (i.e., autoimmunity, complement, inflammatory activation, etc.). Clarifying details of the pathogenic cascade is basic to limit the progression from starting inflammation to degenerative stages. The balance between tissue injury, activation of protective systems and renal tissue repair determines the final outcome. Induction of an oxidative stress is part of glomerular inflammation and activation of protective antioxidant systems has a crucial role in reducing tissue effects. The generation of highly reactive oxygen species can be evaluated in vivo by tracing the inner-layer content of phosphatidyl ethanolamine and phosphatidyl serine in cell membranes. Albumin is the major antioxidant in serum and the level of oxidized albumin is another indirect sign of oxidative stress. Studies performed in Gn, specifically in FSGS, showed a high degree of oxidation in most contexts. High levels of circulating anti-SOD2 antibodies, limiting the detoxyfing activity of SOD2, have been detected in autoimmune Gn(lupus nephritis and membranous nephropathy) in association with persistence of proteinuria and worsening of renal function. In renal transplant, high levels of circulating anti-Glutathione S-transferase antibodies have been correlated with chronic antibody rejection and progressive loss of renal function. Annexins, mainly ANXA1 and ANXA2, play a general anti-inflammatory effect by inhibiting neutrophil functions. Cytosolic ANXA1 is decreased in apoptotic neutrophils of patients with glomerular polyangitis in association with delayed apoptosis that is considered the mechanism for polyangitis. High circulating levels of anti-ANXA1 and anti-ANXA2 antibodies characterize lupus nephritis implying a reduced anti-inflammatory effect. High circulating levels of antibodies targeting Macrophages (anti-FMNL1) have been detected in Gn in association with proteinuria. They potentially modify the intra-glomerular presence of protective macrophages (M2a, M2c) thus acting on the composition of renal infiltrate and on tissue repair.
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Zhang, Wenrui. „Bioactivity Applications of Lycium Barbarum Polysaccharide In Regulating Human Health“. Highlights in Science, Engineering and Technology 11 (23.08.2022): 152–57. http://dx.doi.org/10.54097/hset.v11i.1362.
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For approximately 2,000 years, Lycium barbarum was regarding as a traditional medicine, and was believed that Wolfberry can nourish the liver, eyes, and kidneys. The fruit of Goji berries can also be eaten as food, and these berries have various biological importance, its anti-inflammatory, antioxidant, anti-tumor, hypoglycemic, hypolipidemic and anti-aging effects were discovered. Among those bioactive components, the most important one is Lycium Barbarum polysaccharide (LBP). LBP main structures include β-(1→3)-galp, α-(1→4)-galA, α-(1→6)-glc, β-(1→6)-galp, β-(1→4)-galp, and α-(1→5)-ara. There are various ways in which LBP is extracted. Various studies have demonstrated that LBP possess various biological activities. The main activities of LBP are anti-oxidation, anti-cancer and metabolic regulation. It can also be used in nerve damage repair, liver protection and eye protection. In this article, the structure of LBP and its medicinal value will be summarized as a reference for its further applications.
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Lai, Yi-Fen, Ting-Yi Lin, Pin-Kuan Ho, Yi-Hao Chen, Yu-Chuan Huang und Da-Wen Lu. „Erythropoietin in Optic Neuropathies: Current Future Strategies for Optic Nerve Protection and Repair“. International Journal of Molecular Sciences 23, Nr. 13 (27.06.2022): 7143. http://dx.doi.org/10.3390/ijms23137143.
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Erythropoietin (EPO) is known as a hormone for erythropoiesis in response to anemia and hypoxia. However, the effect of EPO is not only limited to hematopoietic tissue. Several studies have highlighted the neuroprotective function of EPO in extra-hematopoietic tissues, especially the retina. EPO could interact with its heterodimer receptor (EPOR/βcR) to exert its anti-apoptosis, anti-inflammation and anti-oxidation effects in preventing retinal ganglion cells death through different intracellular signaling pathways. In this review, we summarized the available pre-clinical studies of EPO in treating glaucomatous optic neuropathy, optic neuritis, non-arteritic anterior ischemic optic neuropathy and traumatic optic neuropathy. In addition, we explore the future strategies of EPO for optic nerve protection and repair, including advances in EPO derivates, and EPO deliveries. These strategies will lead to a new chapter in the treatment of optic neuropathy.
14
Zhao, Wenwen, Feixiang Li, Xianghong Lv, Jianxiu Chang, Sicong Shen, Pan Dai, Yuan Xia und Zhongyue Cao. „Research Progress of Organic Corrosion Inhibitors in Metal Corrosion Protection“. Crystals 13, Nr. 9 (30.08.2023): 1329. http://dx.doi.org/10.3390/cryst13091329.
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Metal materials are vulnerable to corrosion in the process of production and service, which often leads to serious disasters, including the decline of the performance of metal components and the shortened service life, and even causes catastrophic accidents and ecological damage. Adding a certain amount of corrosion inhibitors (CIs) to the corrosive medium is a simple, efficient, and economical anti-corrosion method to slow down and restrain the corrosion of metal materials. Organic corrosion inhibitors (OCIs) are considered to have good application prospects and are widely used for surface anti-corrosion of metal materials, as they generally have advantages such as good metal adsorption, low oxidation resistance, good thermal and chemical stability, and green environmental protection. This paper systematically summarized some major OCIs, including alkyl chains, imidazoles, and pyridines, and their structural characteristics, as well as the action mechanism of OCIs. Moreover, this paper discusses some natural compounds used as environmentally friendly CIs and provides a prospect for the development trend of OCIs.
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Li, Aoran, Ruoshi Xiao, Sijia He, Xiaoyu An, Yi He, Chengtao Wang, Sheng Yin, Bin Wang, Xuewei Shi und Jingren He. „Research Advances of Purple Sweet Potato Anthocyanins: Extraction, Identification, Stability, Bioactivity, Application, and Biotransformation“. Molecules 24, Nr. 21 (23.10.2019): 3816. http://dx.doi.org/10.3390/molecules24213816.
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Purple sweet potato anthocyanins are kinds of natural anthocyanin red pigments extracted from the root or stem of purple sweet potato. They are stable and have the functions of anti-oxidation, anti-mutation, anti-tumor, liver protection, hypoglycemia, and anti-inflammation, which confer them a good application prospect. Nevertheless, there is not a comprehensive review of purple sweet potato anthocyanins so far. The extraction, structural characterization, stability, functional activity, application in the food, cosmetics, medicine, and other industries of anthocyanins from purple sweet potato, together with their biotransformation in vitro or by gut microorganism are reviewed in this paper, which provides a reference for further development and utilization of anthocyanins.
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Ahlstedt, Jonas, Thuy Tran, Sven-Erik Strand, Magnus Gram und Bo Åkerström. „Human Anti-Oxidation Protein A1M—A Potential Kidney Protection Agent in Peptide Receptor Radionuclide Therapy“. International Journal of Molecular Sciences 16, Nr. 12 (18.12.2015): 30309–20. http://dx.doi.org/10.3390/ijms161226234.
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Xu, Baosheng, Yumin An, Peng Wang, Xinxin Jin und Guangdong Zhao. „Microstructure and ablation behavior of double anti-oxidation protection for carbon-bonded carbon fiber composites“. Ceramics International 43, Nr. 1 (Januar 2017): 783–90. http://dx.doi.org/10.1016/j.ceramint.2016.10.009.
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Speisky, Hernán, María Fernanda Arias-Santé und Jocelyn Fuentes. „Oxidation of Quercetin and Kaempferol Markedly Amplifies Their Antioxidant, Cytoprotective, and Anti-Inflammatory Properties“. Antioxidants 12, Nr. 1 (09.01.2023): 155. http://dx.doi.org/10.3390/antiox12010155.
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The contention that flavonoids’ oxidation would necessarily lead to a loss of their antioxidant properties was recently challenged by the demonstration that quercetin oxidation leads to the formation of 2-(3,4-dihydroxybenzoyl)-2,4,6-trihydroxy-3(2H)-benzofuranone (Que-BZF), a metabolite whose antioxidant potency was notably higher than that of its precursor. Here, we compared and expanded the former observation to that of the quercetin analogue kaempferol. Oxidation of kaempferol led to the formation of a mixture of metabolites that included the 2-(4-hydroxybenzoyl)-2,4,6-trihydroxy-3(2H)-benzofuranone (Kae-BZF). Following the chromatographic isolation of Kae-BZF from such a mixture, its antioxidant, mitochondria- and cell-protecting, and NF-kB-inhibiting effects were assessed, and compared with those of Que-BZF, in Caco-2 cells exposed to indomethacin as a source of ROS. The concentrations of Que-BZF (100 nm) and Kae-BZF (1 nm) needed to attain their maximal protection effects were 50- and 5000-fold lower than those of their respective precursors. The former differences in concentrations were also seen when the abilities of Que-BZF and Kae-BZF to inhibit the indomethacin-induced activation of NF-kB were compared. These data not only reveal that the oxidative conversion of quercetin and kaempferol into their respective 2-benzoyl-2-hydroxy-3(2H)-benzofuranones (BZF) results in a considerable amplification of their original antioxidant properties, but also that the in the case of kaempferol, such amplification is 100-fold greater than that of quercetin.
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Lv, Yongqi, Huichao Cheng, Zhanji Geng und Wei Li. „Oxidation Behavior of (Mo,Hf)Si2-Al2O3 Coating on Mo-Based Alloy at Elevated Temperature“. Materials 16, Nr. 8 (19.04.2023): 3215. http://dx.doi.org/10.3390/ma16083215.
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To improve the oxidation resistance of Mo-based alloys, a novel (Mo,Hf)Si2-Al2O3 composite coating was fabricated on a Mo-based alloy by the method of slurry sintering. The isothermal oxidation behavior of the coating was evaluated at 1400 °C. The microstructure evolution and phase composition of the coating before and after oxidation exposure were characterized. The anti-oxidant mechanism for the good performance of the composite coating during high-temperature oxidation was discussed. The coating had a double-layer structure consisting of a MoSi2 inner layer and a (Mo,Hf)Si2-Al2O3 outer composite layer. The composite coating could offer more than 40 h of oxidation-resistant protection at 1400 °C for the Mo-based alloy, and the final weight gain rate was only 6.03 mg/cm2 after oxidation. A SiO2-based oxide scale embedded with Al2O3, HfO2, mullite, and HfSiO4 was formed on the surface of the composite coating during oxidation. The composite oxide scale exhibited high thermal stability, low oxygen permeability, and enhanced thermal mismatch between oxide and coating layers, thus improving the oxidation resistance of the coating.
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Lv, Ziqi, Kai Ren, Tao Liu, Yunyan Zhao, Zhonghua Zhang und Guicun Li. „Design Polyaniline/α-Zirconium Phosphate Composites for Achieving Self-Healing Anti-Corrosion of Carbon Steel“. Nanomaterials 14, Nr. 1 (27.12.2023): 76. http://dx.doi.org/10.3390/nano14010076.
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The rupture of a micro/nano container can trigger the release of repair agents and provides the coating with a self-healing and anti-corrosion effect. However, the defect and inhomogeneity of the coating, produced by the rupture of the micro/nano container, may weaken its anti-corrosion performance. This study reports a rare protection mechanism, which optimizes the space occupying of zirconium phosphate, and the de-doping peculiarity of polyaniline without the rupture of the micro/nano container. Polyaniline/α-zirconium phosphate composites were constructed through in situ oxidation polymerization. Repair agents were added in the form of doped acids. According to the different repair agents in polyaniline/α-zirconium phosphate composites (citric ion, tartaric ion and phytic ion), the performance and protection mechanism of the composites were researched. Polyaniline/α-zirconium phosphate coating (with phytic ion) shows an excellent self-healing anti-corrosive effect, due to the large spatial structure and abundant chelating groups of the precipitation inhibitor. Considering the anti-corrosive application, the developed polyaniline/α-zirconium phosphate composite has a far-reaching influence on marine development.
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Yoon, Seok, Chae Lim, Hwa-Jee Chung, Joo-Hwan Kim, Yang Huh, Keedon Park und Sekyoo Jeong. „Autophagy Activation by Crepidiastrum Denticulatum Extract Attenuates Environmental Pollutant-Induced Damage in Dermal Fibroblasts“. International Journal of Molecular Sciences 20, Nr. 3 (26.01.2019): 517. http://dx.doi.org/10.3390/ijms20030517.
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Pollution-induced skin damage results in oxidative stress; cellular toxicity; inflammation; and, ultimately, premature skin aging. Previous studies suggest that the activation of autophagy can protect oxidation-induced cellular damage and aging-like changes in skin. In order to develop new anti-pollution ingredients, this study screened various kinds of natural extracts to measure their autophagy activation efficacy in cultured dermal fibroblast. The stimulation of autophagy flux by the selected extracts was further confirmed both by the expression of proteins associated with the autophagy signals and by electron microscope. Crepidiastrum denticulatum (CD) extract treated cells showed the highest autophagic vacuole formation in the non-cytotoxic range. The phosphorylation of adenosine monophosphate kinase (AMPK), but not the inhibition of mammalian target of rapamycin (mTOR), was observed by CD-extract treatment. Its anti-pollution effects were further evaluated with model compounds, benzo[a]pyrene (BaP) and cadmium chloride (CdCl2), and a CD extract treatment resulted in both the protection of cytotoxicity and a reduction of proinflammatory cytokines. These results suggest that the autophagy activators can be a new protection regimen for anti-pollution. Therefore, CD extract can be used for anti-inflammatory and anti-pollution cosmetic ingredients.
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Zhang, Zhong Li, Qi Shen Wang, Peng Rao Wei und Xue Gong. „Arc-Spraying Composite Coatings on Mild Steel for Long-Term High-Temperature Oxidation Protection“. Advanced Materials Research 690-693 (Mai 2013): 2039–45. http://dx.doi.org/10.4028/www.scientific.net/amr.690-693.2039.
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An arc-spraying composite coating system for high-temperature oxidation protection is composed of an inner Fe-Cr-Al alloy layer and an Al-Si alloy outer layer. The high-temperature oxidation behavior of the composite coatings on steel substrate was studied during isothermal exposures in air at 900°C. Experiments show that the coatings on steel substrate are not deteriorated and the substrate is protected well, being exposed to high temperatures up to 900°C. Inter diffusion of alloying elements within the protective coatings occur, while the elements, Cr and Al, are also diffusing to the core of the base metal. As test time proceeds, a large number of chromium oxides are generated in situ within the protective coatings, especially close to the coating/substrate interface. The oxides generated increase the bond strength of the coating to the steel substrate, and together with the surface alumina they provide a long-term effective anti-oxidant protection to steel substrate. The results on titanium sponge production site show that the protective coatings on the reactor have provided an effective protection and prolong the lifetime at least forty percent for the reactors.
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Li, Benjiao, Song Li, Binrong Ma, Yong Jing, Zheming Zhang, Zhijia Li und Dequan Zeng. „Research progress on the safety evaluation of selenium enriched yeast“. E3S Web of Conferences 185 (2020): 04011. http://dx.doi.org/10.1051/e3sconf/202018504011.
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Selenium-enriched yeast has the physiological functions of improving immunity, anti-oxidation, liver protection, lipid-lowering and anti-cancer. Currently, it is widely used as an organic selenium supplement to prevent diseases of livestock and poultry and aquatic animals, and increase the rate of littering and egg production rate of poultry, reduce the mortality of fish and other aquatic animals, and promote the growth of livestock and poultry. This article reviews the acute toxicity, genotoxicity and subchronic toxicity of selenium-enriched yeast, in order to provide a reference for the safe application of selenium-enriched yeast.
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Zhai, Xuan, Kangmin Wang, Xingyi Gao und Bin Yan. „Research Progress on Chemical Constituents and Pharmacological Activities of Menispermi Rhizoma“. Molecules 28, Nr. 6 (16.03.2023): 2701. http://dx.doi.org/10.3390/molecules28062701.
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Menispermi Rhizoma, the rhizome of Menispermum dauricum DC., is a traditional Chinese medicine, which has the effect of clearing away heat and detoxification, dispelling wind, and relieving pain. It is often used in the treatment of sore throat, enteritis, dysentery, and rheumatism. The chemical constituents of M. Rhizoma mainly include alkaloids, phenolic acids, quinones, cardiotonic glycosides, and so on. Modern pharmacological studies have proved that M. Rhizoma has the effects of anti-tumour, anti-inflammation, anti-oxidation, bacteriostasis, cardio-cerebrovascular protection, anti-depression and anti-Alzheimer’s disease. In recent years, the chemical constituents of M. Rhizoma have been found continuously, and the pharmacological studies have deepened gradually. This paper reviews the research progress on the chemical composition and pharmacological effects of M. Rhizoma, to provide a basis for further research and development of its medicinal value.
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Verlotski, Vadim, und Goetz Matthaeus. „ChroSiMol: A Completely Different Coating Against Corrosion and Wear“. Journal of Thermal Spray and Engineering 1, Nr. 1 (2018): 13–17. http://dx.doi.org/10.52687/2582-1474/113.
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The paper deals with new layers of the systems Cr-Mo-Ni-Si and Cr-Mo-Co-Si bearing the common name "ChroSiMol". These layers are applied by means of atmospheric plasma spraying on metallic substrates of iron, nickel, cobalt, and titanium-based alloys and serve as corrosion, oxidation and wear protection for these metals at temperatures up to max. 900°C. The layer ChroSiMol is an acid-resistant layer and provides for its substrates a perfect protection against hot sulfuric acid and phosphoric acid in all concentrations. With a hardness of approx. 900 HV and very good anti-friction properties of the molybdenum-containing surface, these layers are optimally suited for use with friction pairs with corrosive loads.
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Grasset, Emilie K., Amanda Duhlin, Hanna E. Agardh, Olga Ovchinnikova, Thomas Hägglöf, Mattias N. Forsell, Gabrielle Paulsson-Berne, Göran K. Hansson, Daniel F. J. Ketelhuth und Mikael C. I. Karlsson. „Sterile inflammation in the spleen during atherosclerosis provides oxidation-specific epitopes that induce a protective B-cell response“. Proceedings of the National Academy of Sciences 112, Nr. 16 (06.04.2015): E2030—E2038. http://dx.doi.org/10.1073/pnas.1421227112.
Annotation:
The B-cell response in atherosclerosis is directed toward oxidation-specific epitopes such as phosphorylcholine (PC) that arise during disease-driven oxidation of self-antigens. PC-bearing antigens have been used to induce atheroprotective antibodies against modified low-density lipoproteins (oxLDL), leading to plaque reduction. Previous studies have found that B-cell transfer from aged atherosclerotic mice confers protection to young mice, but the mechanism is unknown. Here, we dissected the atheroprotective response in the spleen and found an ongoing germinal center reaction, accumulation of antibody-forming cells, and inflammasome activation in apolipoprotein E-deficient mice (Apoe−/−). Specific B-cell clone expansion involved the heavy chain variable region (Vh) 5 and Vh7 B-cell receptor families that harbor anti-PC reactivity. oxLDL also accumulated in the spleen. To investigate whether protection could be induced by self-antigens alone, we injected apoptotic cells that carry the same oxidation-specific epitopes as oxLDL. This treatment reduced serum cholesterol and inhibited the development of atherosclerosis in a B-cell–dependent manner. Thus, we conclude that the spleen harbors a protective B-cell response that is initiated in atherosclerosis through sterile inflammation. These data highlight the importance of the spleen in atherosclerosis-associated immunity.
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Pedersen, Bente Klarlund. „The anti-inflammatory effect of exercise: its role in diabetes and cardiovascular disease control“. Essays in Biochemistry 42 (27.11.2006): 105–17. http://dx.doi.org/10.1042/bse0420105.
Annotation:
Chronic low-grade systemic inflammation is a feature of chronic diseases such as cardiovascular disease and type 2 diabetes. Regular exercise offers protection against all-cause mortality, primarily by protection against atherosclerosis and insulin resistance and there is evidence that physical training is effective as a treatment in patients with chronic heart diseases and type 2 diabetes. Regular exercise induces anti-inflammatory actions. During exercise, IL-6 (interleukin-6) is produced by muscle fibres. IL-6 stimulates the appearance in the circulation of other anti-inflammatory cytokines such as IL-1ra (interleukin-1 receptor antagonist) and IL-10 (interleukin-10) and inhibits the production of the pro-inflammatory cytokine TNF-a (tumour necrosis factor-a). In addition, IL-6 enhances lipid turnover, stimulating lipolysis as well as fat oxidation. It is suggested that regular exercise induces suppression of TNF-a and thereby offers protection against TNF-a-induced insulin resistance. Recently, IL-6 was introduced as the first myokine, defined as a cytokine, that is produced and released by contracting skeletal muscle fibres, exerting its effects in other organs of the body. Myokines may be involved in mediating the beneficial health effects against chronic diseases associated with low-grade inflammation such as diabetes and cardiovascular diseases.
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Petersen, Anne Marie W., und Bente Klarlund Pedersen. „The anti-inflammatory effect of exercise“. Journal of Applied Physiology 98, Nr. 4 (April 2005): 1154–62. http://dx.doi.org/10.1152/japplphysiol.00164.2004.
Annotation:
Regular exercise offers protection against all-cause mortality, primarily by protection against cardiovascular disease and Type 2 diabetes mellitus. The latter disorders have been associated with chronic low-grade systemic inflammation reflected by a two- to threefold elevated level of several cytokines. Adipose tissue contributes to the production of TNF-α, which is reflected by elevated levels of soluble TNF-α receptors, IL-6, IL-1 receptor antagonist, and C-reactive protein. We suggest that TNF-α rather than IL-6 is the driver behind insulin resistance and dyslipidemia and that IL-6 is a marker of the metabolic syndrome, rather than a cause. During exercise, IL-6 is produced by muscle fibers via a TNF-independent pathway. IL-6 stimulates the appearance in the circulation of other anti-inflammatory cytokines such as IL-1ra and IL-10 and inhibits the production of the proinflammatory cytokine TNF-α. In addition, IL-6 enhances lipid turnover, stimulating lipolysis as well as fat oxidation. We suggest that regular exercise induces suppression of TNF-α and thereby offers protection against TNF-α-induced insulin resistance. Recently, IL-6 was introduced as the first myokine, defined as a cytokine that is produced and released by contracting skeletal muscle fibers, exerting its effects in other organs of the body. Here we suggest that myokines may be involved in mediating the health-beneficial effects of exercise and that these in particular are involved in the protection against chronic diseases associated with low-grade inflammation such as diabetes and cardiovascular diseases.
29
Su, Wenjing, Anna V. Mastova, Maya A. Ul’yanova, Polina A. Kononova, Olga Yu Selyutina, Veronika I. Evseenko, Elizaveta S. Meteleva, Alexander V. Dushkin, Weike Su und Nikolay E. Polyakov. „NMR Study of Water-Soluble Carotenoid Crocin: Formation of Mixed Micelles, Interaction with Lipid Membrane and Antioxidant Activity“. International Journal of Molecular Sciences 25, Nr. 6 (11.03.2024): 3194. http://dx.doi.org/10.3390/ijms25063194.
Annotation:
Crocin is a unique water-soluble carotenoid found in crocus and gardenia flowers. Crocin has been shown to have a variety of pharmacological activities, such as antioxidant, anti-cancer, memory improvement, antidepressant, anti-ischemia, blood pressure lowering and aphrodisiac, gene protection and detoxification activities. Due to their amphiphilicity, crocin molecules form concentration-dependent self-associates (micelles) in a water solution. In the present study, using various NMR techniques (T2 relaxation and selective gradient NOESY), we have demonstrated that crocin forms mixed micelles with water-soluble drug delivery system glycyrrhizin and linoleic acid molecules. Note, that the spin–spin T2 relaxation time and NOESY spectroscopy are very sensitive to intermolecular interactions and molecular diffusion mobility. The second purpose of this work was the elucidation of the interaction of crocin with a model lipid membrane using NMR techniques and a molecular dynamics simulation and its effects on lipid oxidation. It was shown that the crocin molecule is located near the surface of the lipid bilayer and effectively protects lipids from oxidation by peroxyl radicals. The role of glycyrrhizin and vitamin C in metal-induced lipid oxidation was also elucidated. The results of this study may be useful for expanding the field of application of crocin in medicine and in the food industry.
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Sridharan, B., J. M. Zhang und M. J. Lee. „In vitro anti-oxidant property and reduction of hyperglycemia-induced oxidation by hydroalcoholic extract of Phyllanthus emblica in cultured mesangial cell lines“. IOP Conference Series: Earth and Environmental Science 858, Nr. 1 (01.09.2021): 012003. http://dx.doi.org/10.1088/1755-1315/858/1/012003.
Annotation:
Abstract The pathology of diabetic nephropathy (DN) is due to long-term poor blood sugar control leading to changes in the filtration unit of the kidneys. However, drugs used to offer renal protection cause many side effects. Therefore, it is necessary to develop a new drug or food supplement that acts on multiple factors of DN. Studies have confirmed that Phyllanthus emblica (PE) has anti-diabetic, free radical scavenging, anti-inflammatory, immune regulation, antipyretic, analgesic, wound healing, anti-atherosclerosis, liver protection, kidney protection, and neuroprotection properties. In this study, we explored the antioxidant activity and ability to maintain redox balance in MES-13 cell line. We performed DPPH and FRAP assay to detect the antioxidant property of PE. SDS-PAGE was performed to understand the changes in the types of protein of the glomerular cells treated (24 hr) with high sugar (25 mM) with/without PE extract (10 & 100 μg/ml). Oxidative stress in cells was detected by RedCC-1 staining. Significant antioxidant activity was shown by the extract (IC50 – 108.9 μg/ml) compared to Trolox (IC50 – 60.9 μg/ml). The protein pattern of high glucose (25 mM) treated cells significantly reduced compared to normal and PE treated cells. Mitochondrial dysfunction and cellular oxidative stress produced by high glucose (intensity - 222.04 units) supplementation was significantly reduced by PE (intensity - 38.67 units). In conclusion, PE extract possesses an antioxidant property that can reduce the glomerular damage and oxidative stress in the cells caused by high glucose exposure
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Nikula, P., H. Ruohola, L. Alhonen-Hongisto und J. Jänne. „Carnitine prevents the early mitochondrial damage induced by methylglyoxal bis(guanylhydrazone) in L1210 leukaemia cells“. Biochemical Journal 228, Nr. 2 (01.06.1985): 513–16. http://dx.doi.org/10.1042/bj2280513.
Annotation:
We previously found that the anti-cancer drug methylglyoxal bis(guanylhydrazone) (mitoguazone) depresses carnitine-dependent oxidation of long-chain fatty acids in cultured mouse leukaemia cells [Nikula, Alhonen-Hongisto, Seppänen & Jänne (1984) Biochem. Biophys. Res. Commun. 120, 9-14]. We have now investigated whether carnitine also influences the development of the well-known mitochondrial damage produced by the drug in L1210 leukaemia cells. Palmitate oxidation was distinctly inhibited in tumour cells exposed to 5 microM-methylglyoxal bis(guanylhydrazone) for only 7 h. Electron-microscopic examination of the drug-exposed cells revealed that more than half of the mitochondria were severely damaged. Similar exposure of the leukaemia cells to the drug in the presence of carnitine not only abolished the inhibition of fatty acid oxidation but almost completely prevented the drug-induced mitochondrial damage. The protection provided by carnitine appeared to depend on the intracellular concentration of methylglyoxal bis(guanylhydrazone), since the mitochondria-sparing effect disappeared at higher drug concentrations.
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Zhu, Yanna, Shilei Yang, Linlin Lv, Xiaohan Zhai, Guoyu Wu, Xiaolin Qi, Deshi Dong und Xufeng Tao. „Research Progress on the Positive and Negative Regulatory Effects of Rhein on the Kidney: A Review of Its Molecular Targets“. Molecules 27, Nr. 19 (04.10.2022): 6572. http://dx.doi.org/10.3390/molecules27196572.
Annotation:
Currently, both acute kidney injury (AKI) and chronic kidney disease (CKD) are considered to be the leading public health problems with gradually increasing incidence rates around the world. Rhein is a monomeric component of anthraquinone isolated from rhubarb, a traditional Chinese medicine. It has anti-inflammation, anti-oxidation, anti-apoptosis, anti-bacterial and other pharmacological activities, as well as a renal protective effects. Rhein exerts its nephroprotective effects mainly through decreasing hypoglycemic and hypolipidemic, playing anti-inflammatory, antioxidant and anti-fibrotic effects and regulating drug-transporters. However, the latest studies show that rhein also has potential kidney toxicity in case of large dosages and long use times. The present review highlights rhein’s molecular targets and its different effects on the kidney based on the available literature and clarifies that rhein regulates the function of the kidney in a positive and negative way. It will be helpful to conduct further studies on how to make full use of rhein in the kidney and to avoid kidney damage so as to make it an effective kidney protection drug.
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Chawla, Raman, Rajesh Arora, Ravinder K. Sagar, Shikha Singh, Satish C. Puri, Raj Kumara, Surender Singh et al. „3-O-β-ᴅ-Galactopyranoside of Quercetin as an Active Principle from High Altitude Podophyllum hexandrum and Evaluation of its Radioprotective Properties“. Zeitschrift für Naturforschung C 60, Nr. 9-10 (01.10.2005): 728–38. http://dx.doi.org/10.1515/znc-2005-9-1012.
Annotation:
Abstract The aqueous-ethanolic extract (AEE) of high altitude Podophyllum hexandrum has earlier been reported to render a radioprotective effect against lethal gamma radiation in in vitro model. AEE has also been reported to possess metal chelating and DNA protecting properties. The present study was undertaken to isolate and characterize the bioactive principle present in AEE and investigate its role in radiation protection. A novel molecule was found to be present in AEE and was assigned as 3-O-β-ᴅ-galactoside of quercetin by acid hydrolysis, LC-MS, LC-APCI-MS/MS and 13C NMR spectra. Various biological activities were investigated at in vitro level. The antioxidant potential of AEE in lipid and aqueous phase was determined against numerous stresses. AEE was found to be significantly (p < 0.05) protective, i.e., against Fe2+ and Cu2+-induced linoleic acid degradation, respectively. Radiationinduced lipid oxidation studies revealed that AEE maximally works at a [lignan]/0.25 kGy ratio 400 (ratio of concentration of AEE divided by the radiation dose, i.e., 0.25 kGy) and no drug-induced lipid oxidation at all concentrations tested was found. In a time-dependent study, total antioxidant activity was maximally exhibited at 1 mg/ml. The site-specific and non-site-specific deoxyribose degradation assay exhibited a dose-dependant hydroxyl scavenging potential of AEE (0.05-500 μg/ml). The anti-lipid peroxidation ability of AEE against radiation (0.25 kGy)-induced lipid peroxidation was higher in case of neural tissue homogenate as compared to kidney homogenate [activity ratio: 0.039 (brain) < 0.24 (kidney)]. The protein protection study using bovine serum albumin was also done for two time intervals (2 h and 4 h) and significant (p < 0.05) protection was observed at 500 μg/ml (> 97%). This study implies that 3-O-β-ᴅ-galactoside present in AEE renders radioprotection by protecting lipids, proteins in renal and neural model system against supra-lethal (0.25 kGy) gamma radiation.
34
Cho, Kyung-Hyun, Ji-Eun Kim, Hyo-Seon Nam, Dae-Jin Kang und Seung-Hee Baek. „Comparison of Policosanols via Incorporation into Reconstituted High-Density Lipoproteins: Cuban Policosanol (Raydel®) Exerts the Highest Antioxidant, Anti-Glycation, and Anti-Inflammatory Activity“. Molecules 28, Nr. 18 (20.09.2023): 6715. http://dx.doi.org/10.3390/molecules28186715.
Annotation:
Reconstituted high-density lipoproteins (rHDL) containing each policosanol from Cuba (Raydel®), China (Shaanxi Pioneer), and the United States (Lesstanol®) were synthesized to compare the physiological properties of policosanol depending on sources and origin countries. After synthesis with apolipoproteinA-I (apoA-I) into rHDL, all policosanols bound well with phospholipid and apoA-I to form discoidal rHDL. An rHDL containing Cuban policosanol (rHDL-1) showed the largest rHDL particle size of around 83 ± 3 nm, while rHDL containing Chinese policosanol (rHDL-2) or American policosanol (rHDL-3) showed smaller particles around 63 ± 3 nm and 60 ± 2 nm in diameter, respectively. The rHDL-1 showed the strongest anti-glycation activity to protect the apoA-I degradation of HDL from fructose-mediated glycation: approximately 2.7-times higher ability to suppress glycation and 1.4-times higher protection ability of apoA-I than that of rHDL-2 and rHDL-3. The rHDL-1 showed the highest antioxidant ability to inhibit cupric ion-mediated LDL oxidation in electromobility and the quantification of oxidized species. A microinjection of each rHDL into a zebrafish embryo in the presence of carboxymethyllysine (CML) showed that rHDL-1 displayed the strongest anti-oxidant activity with the highest embryo survivability, whereas rHDL-2 and rHDL-3 showed much weaker protection ability, similar to rHDL alone (rHDL-0). An intraperitoneal injection of CML (250 μg) into adult zebrafish caused acute death and hyperinflammation with an elevation of infiltration of neutrophils and IL-6 production in the liver. On the other hand, a co-injection of rHDL-1 resulted in the highest survivability and the strongest anti-inflammatory ability to suppress IL-6 production with an improvement of the blood lipid profile, such as elevation of HDL-C and lowering of the total cholesterol, LDL-cholesterol, and triglyceride. In conclusion, Cuban policosanol exhibited the most desirable properties for the in vitro synthesis of rHDL with the stabilization of apoA-I, the largest particle size, anti-glycation against fructation, and antioxidant activities to prevent LDL oxidation. Cuban policosanol in rHDL also exhibited the strongest in vivo antioxidant and anti-inflammatory activities with the highest survivability in zebrafish embryos and adults via the prevention of hyperinflammation in the presence of CML.
35
Teo, Jye Yng, Yongbeom Seo, Eunkyung Ko, Jiayu Leong, Yu-Tong Hong, Yi Yan Yang und Hyunjoon Kong. „Surface tethering of stem cells with H2O2-responsive anti-oxidizing colloidal particles for protection against oxidation-induced death“. Biomaterials 201 (Mai 2019): 1–15. http://dx.doi.org/10.1016/j.biomaterials.2019.01.039.
36
Chen, Long, Wei Chen, Miao Cao und Xin Li. „Performance Comparison of Zn-Based and Al–Si Based Coating on Boron Steel in Hot Stamping“. Materials 14, Nr. 22 (20.11.2021): 7043. http://dx.doi.org/10.3390/ma14227043.
Annotation:
The coatings of boron steels play an important role in affecting the quality of hot stamping parts, so it is important to evaluate the hot stamping performance of coatings before designing processes. Taking the U-type hot stamping part of boron steel as research objects, the surface quality, microstructure and temperature variation of samples with GA (galvannealed), GI (galvanized) and Al–Si coatings were observed and analyzed to evaluate the anti-oxidation, forming and quenching performances of different coatings. The results show that all the GA, GI and Al–Si coatings could provide good oxidation protection and also act as the lubricants for avoiding the friction damage of sample substrates and die-surface. But the different compositions of GA, GI and Al–Si coatings will contribute the different colors. Under the same deformation degree, the Al–Si coating can provide the best substrate protection and the GI coating will induce cracks in the substrate because of the liquid metal-induced embrittlement phenomenon. There is no significant difference between the quenching performances of GA, GI and Al–Si coatings, and the thermal conductivity of the GI coating is slightly better than Al–Si and GA coatings.
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Brandt, Claus, und Bente K. Pedersen. „The Role of Exercise-Induced Myokines in Muscle Homeostasis and the Defense against Chronic Diseases“. Journal of Biomedicine and Biotechnology 2010 (2010): 1–6. http://dx.doi.org/10.1155/2010/520258.
Annotation:
Chronic inflammation is involved in the pathogenesis of insulin resistance, atherosclerosis, neurodegeneration, and tumour growth. Regular exercise offers protection against type 2 diabetes, cardiovascular diseases, colon cancer, breast cancer, and dementia. Evidence suggests that the protective effect of exercise may to some extent be ascribed to the antiinflammatory effect of regular exercise. Here we suggest that exercise may exert its anti-inflammatory effect via a reduction in visceral fat mass and/or by induction of an anti-inflammatory environment with each bout of exercise. According to our theory, such effects may in part be mediated via muscle-derived peptides, so-called “myokines”. Contracting skeletal muscles release myokines with endocrine effects, mediating direct anti-inflammatory effects, and/or specific effects on visceral fat. Other myokines work locally within the muscle and exert their effects on signalling pathways involved in fat oxidation and glucose uptake. By mediating anti-inflammatory effects in the muscle itself, myokines may also counteract TNF-driven insulin resistance. In conclusion, exercise-induced myokines appear to be involved in mediating both systemic as well as local anti-inflammatory effects.
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Zhang, Zhong Li, Pen Yao Wei, Nan Nan Zhang, Qi Shen Wang und Xue Gong. „Oxidation Protective Barrier Coatings for Austenitic Stainless Steels at 1100°C“. Applied Mechanics and Materials 395-396 (September 2013): 726–31. http://dx.doi.org/10.4028/www.scientific.net/amm.395-396.726.
Annotation:
An arc-sprayed oxidation protective barrier coating system on austenitic stainless steel is composed of an inner Ni-Cr-Ti alloy layer and a pure aluminum outer layer. The high-temperature oxidation behavior of the coatings on 304N substrate was investigated during isothermal exposures in air at 1100°C. Experiments showed that interdiffusion of alloying elements within the protective coatings occurred, and the elements, Cr,Ni and Al, were also diffusing into the substrate metal. As test time proceeded, aluminum nitrides were generated in situ in the substrate, which had a layer-like distribution. The nitrides generated play the roles as element diffusion barriers, and together with the surface alumina they provide a long-term effective anti-oxidant protection to the steel substrate. The coatings on 304N substrate were not deteriorated and the substrate was protected well, being exposed to 1100°C for 350 hours. The analysis results of oxidation kinetics showed that the specific mass changes of the coated specimens were much smaller than those without coatings.
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Cho, Kyung-Hyun, Ashutosh Bahuguna, Yunki Lee, Sang Hyuk Lee, Maria del Carmen Dominguez-Horta und Gillian Martinez-Donato. „Synergistic Anti-Inflammatory Activity of Lipid-Free Apolipoprotein (apo) A-I and CIGB-258 in Acute-Phase Zebrafish via Stabilization of the apoA-I Structure to Enhance Anti-Glycation and Antioxidant Activities“. International Journal of Molecular Sciences 25, Nr. 10 (20.05.2024): 5560. http://dx.doi.org/10.3390/ijms25105560.
Annotation:
CIGB-258, a 3 kDa peptide from heat shock protein 60, exhibits synergistic anti-inflammatory activity with apolipoprotein A-I (apoA-I) in reconstituted high-density lipoproteins (rHDLs) via stabilization of the rHDL structure. This study explored the interactions between CIGB-258 and apoA-I in the lipid-free state to assess their synergistic effects in the structural and functional enhancement of apoA-I and HDL. A co-treatment of lipid-free apoA-I and CIGB-258 inhibited the cupric ion-mediated oxidation of low-density lipoprotein (LDL) and a lowering of oxidized species in the dose-responsive manner of CIGB-258. The co-presence of CIGB-258 caused a blue shift in the wavelength of maximum fluorescence (WMF) of apoA-I with protection from proteolytic degradation. The addition of apoA-I:CIGB-258, with a molar ratio of 1:0.1, 1:0.5, and 1:1, to HDL2 and HDL3 remarkably enhanced the antioxidant ability against LDL oxidation up to two-fold higher than HDL alone. HDL-associated paraoxonase activities were elevated up to 28% by the co-addition of apoA-I and CIGB-258, which is linked to the suppression of Cu2+-mediated HDL oxidation with the slowest electromobility. Isothermal denaturation by a urea treatment showed that the co-presence of CIGB-258 attenuated the exposure of intrinsic tryptophan (Trp) and increased the mid-points of denaturation from 2.33 M for apoA-I alone to 2.57 M for an apoA-I:CIGB-258 mixture with a molar ratio of 1:0.5. The addition of CIGB-258 to apoA-I protected the carboxymethyllysine (CML)-facilitated glycation of apoA-I with the prevention of Trp exposure. A co-treatment of apoA-I and CIGB-258 synergistically safeguarded zebrafish embryos from acute death by CML-toxicity, suppressing oxidative stress and apoptosis. In adult zebrafish, the co-treatment of apoA-I+CIGB-258 exerted the highest anti-inflammatory activity with a higher recovery of swimming ability and survivability than apoA-I alone or CIGB-258 alone. A co-injection of apoA-I and CIGB-258 led to the lowest infiltration of neutrophils and interleukin (IL)-6 generation in hepatic tissue, with the lowest serum triglyceride, aspartate transaminase, and alanine transaminase levels in plasma. In conclusion, the co-presence of CIGB-258 ameliorated the beneficial functionalities of apoA-I, such as antioxidant and anti-glycation activities, by enhancing the structural stabilization and protection of apoA-I. The combination of apoA-I and CIGB-258 synergistically enforced the anti-inflammatory effect against CML toxicity in embryos and adult zebrafish.
40
Jin, Runze, Zihan Zhou, Jia Liu, Baolu Shi, Ning Zhou, Xinqiao Wang, Xinlei Jia, Donghui Guo und Baosheng Xu. „Aerogels for Thermal Protection and Their Application in Aerospace“. Gels 9, Nr. 8 (26.07.2023): 606. http://dx.doi.org/10.3390/gels9080606.
Annotation:
With the continuous development of the world’s aerospace industry, countries have put forward higher requirements for thermal protection materials for aerospace vehicles. As a nano porous material with ultra-low thermal conductivity, aerogel has attracted more and more attention in the thermal insulation application of aerospace vehicles. At present, the summary of aerogel used in aerospace thermal protection applications is not comprehensive. Therefore, this paper summarizes the research status of various types of aerogels for thermal protection (oxide aerogels, organic aerogels, etc.), summarizes the hot issues in the current research of various types of aerogels for thermal protection, and puts forward suggestions for the future development of various aerogels. For oxide aerogels, it is necessary to further increase their use temperature and inhibit the sintering of high-temperature resistant components. For organic aerogels, it is necessary to focus on improving the anti-ablation, thermal insulation, and mechanical properties in long-term aerobic high-temperature environments, and on this basis, find cheap raw materials to reduce costs. For carbon aerogels, it is necessary to further explore the balanced relationship between oxidation resistance, mechanics, and thermal insulation properties of materials. The purpose of this paper is to provide a reference for the further development of more efficient and reliable aerogel materials for aerospace applications in the future.
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Mölzer, Christine, Hedwig Huber, Andrea Steyrer, Gesa V. Ziesel, Marlies Wallner, Iryna Goncharova, Sergey Orlov et al. „Interaction between TNFone and tetrapyrroles may account for their anti-genotoxic effects — a novel mechanism for DNA-protection“. Journal of Porphyrins and Phthalocyanines 17, Nr. 12 (Dezember 2013): 1157–66. http://dx.doi.org/10.1142/s1088424613500995.
Annotation:
Bilirubin, the principal and biologically most relevant bile pigment was, until recently, considered a waste product of haem catabolism. However, current data suggest that bile pigments possess biological potential, related to their antioxidant and anti-mutagenic effects. In this context, it is now assumed that bile pigments and their derivatives exert these effects via multiple mechanisms, including discrete anti-oxidative and physico-chemical interactive effects. The major scientific focus so far has concentrated on the compounds' antioxidant action, and mechanistic investigations of possible mutagen-tetrapyrrole interaction are lacking. Therefore we tested structurally related bile pigments/derivatives (bilirubin/-ditaurate/-dimethyl ester, biliverdin/-dimethyl ester, urobilin, stercobilin and protoporphyrin) for anti-genotoxicity in the Salmonella reverse mutation assay (strains TA98, TA102), together with the synthetic mutagen 2,4,7-trinitro-9H-fluoren-9-one (TNFone). To explore possible structural interactions, molecular systems of chlorin e6 porphyrin/bilirubin/biliverdin with TNFone were assayed using circular dichroism. These data consistently revealed, at suprastoichiometric concentrations, that tetrapyrroles interact with TNFone. Addition of TNFone to chlorin e6 porphyrin, bilirubin-albumin and biliverdin-albumin led to a marked change in pigment spectra, providing evidence for tight tetrapyrrole-mutagen interaction. This conclusion was also supported by substantial, TNFone-induced decrease of bilirubin oxidation in the bilirubin-albumin system. This outcome was reflected in a bacterial model, in which most tetrapyrroles and especially protoporphyrin, significantly attenuated TNFone-induced mutagenesis. These data indicate that aromatic, tetrapyrrolic molecules interact with TNFone, providing a novel mechanism to suggest the anti-mutagenic effects of bile pigments in vivo are related to their physico-chemical interaction with genotoxins.
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Ahmad, Farooq, Lin Zhang, Jun Zheng, Iram Sidra und Shihong Zhang. „Characterization of AlCrN and AlCrON Coatings Deposited on Plasma Nitrided AISI H13 Steels Using Ion-Source-Enhanced Arc Ion Plating“. Coatings 10, Nr. 4 (25.03.2020): 306. http://dx.doi.org/10.3390/coatings10040306.
Annotation:
The AlCrN and AlCrON coatings were deposited on plasma nitrided H13 steels through ion-source-enhanced arc ion plating, and their structures, mechanical properties, thermal stabilities, and tribological properties were investigated. Structural analysis showed that the monolayer AlCrN and AlCrON bilayered coatings were mainly composed of fcc-AlCrN and fcc-AlCrON solid solution phases respectively. Upon the addition of thin AlCrON layer, the hardness of AlCrN/AlCrON coating slightly decreased from about 30.5 GPa to 28.6 GPa, and the thermal stability was improved after annealing at 700 °C. Both coatings exhibited excellent wear resistance at room temperature, while all wear process involved a combination of wear mechanisms, including severe abrasion and oxidation at an evaluated temperature. The AlCrON bilayered coating showed better wear resistance than that of AlCrN coating due to a dense anti-oxidation layer and better adhesion at a high temperature, making it suitable for die tool protection coatings.
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Ahmed, Tanvir, und Chin-Kun Wang. „Black Garlic and Its Bioactive Compounds on Human Health Diseases: A Review“. Molecules 26, Nr. 16 (19.08.2021): 5028. http://dx.doi.org/10.3390/molecules26165028.
Annotation:
Black garlic (BG) is a form of aged garlic obtained from raw garlic (Allium sativum) via Millard reaction under high temperature (60–90 °C) and humidity (70–90%) for a period of time. Several studies reported higher contents of water-soluble antioxidants compounds (S-allyl cysteine, S-allyl-mercapto cysteine), 5-hydroxymethylfurfural, organosulfur compounds, polyphenol, volatile compounds, and products of other Millard reactions compared to fresh garlic after the thermal processing. Recent studies have demonstrated that BG and its bioactive compounds possess a wide range of biological activities and pharmacological properties that preserve and show better efficacy in preventing different types of diseases. Most of these benefits can be attributed to its anti-oxidation, anti-inflammation, anti-obesity, hepatoprotection, hypolipidemia, anti-cancer, anti-allergy, immunomodulation, nephroprotection, cardiovascular protection, and neuroprotection. Substantial studies have been conducted on BG and its components against different common human diseases in the last few decades. Still, a lot of research is ongoing to find out the therapeutic effects of BG. Thus, in this review, we summarized the pre-clinical and clinical studies of BG and its bioactive compounds on human health along with diverse bioactivity, a related mode of action, and also future challenges.
44
Liu, R., L. Zhang, X. Lan, L. Li, T. T. Zhang, J. H. Sun und G. H. Du. „Protection by borneol on cortical neurons against oxygen-glucose deprivation/reperfusion: involvement of anti-oxidation and anti-inflammation through nuclear transcription factor κappaB signaling pathway“. Neuroscience 176 (März 2011): 408–19. http://dx.doi.org/10.1016/j.neuroscience.2010.11.029.
45
Deng, Shu Hui, und Yong Deng. „Decarburization Depth Control Technology Research and Application for U71Mn Rail“. Advanced Materials Research 774-776 (September 2013): 1181–85. http://dx.doi.org/10.4028/www.scientific.net/amr.774-776.1181.
Annotation:
U71Mn is the main steel grade for high-speed railway rails. In the production of U71Mn rail, its decarburization depth is the deepest, and the qualified percentage is lower than 60% for the requirement of less than 0.3mm of decarburization depth. On the basis of current heating furnace, the influence of different heating processes on the decarburization depth of U71Mn rail was studied, and the result shows that just optimization of heat process can not decrease greatly the decarburization depth. Therefore the high temperature anti-oxidation coating protection technology was carried out in the process of heating of U71Mn rail. Under the condition of protection heating and optimization of heating process, the decarburization depth of U71Mn rail decreases significantly, and the qualified rate reaches to more than 95% for the depth of less than 0.30mm, and 100% for the depth of less than 0.50mm.
46
Deng, Hong Da, Xiao Wei Liu, Xian Long Cao und Mei Yu Zhao. „Effect of Heat Treatment on Anticorrosion of Soft Magnetic Alloy Fe81Cr17Si1.5TiBRe“. Advanced Materials Research 152-153 (Oktober 2010): 550–55. http://dx.doi.org/10.4028/www.scientific.net/amr.152-153.550.
Annotation:
In the present work, the resistances to corrosion of heat treated soft magnetic alloy Fe81Cr17Si1.5TiBRe and untreated one have been comparatively studied, which were tested in neutral salt spaying tester, in 50%vol. hydrochloric acid (HCl) at 100 , in humidity thermal oxidation tester, specially in simulating oilfield waters containing sulfide ion (S2-) and without S2-. Heat treatment was carried out at 1150 for 4 hours under the protection of hydrogen gas. The results show that heat-treatment affect the magnitude of grain of Fe-base soft magnetic alloy and distribution of inclusions in grain and in grain boundaries. Heat treatment enhances anti-corrosion properties, i.e. resistance to chlorine ion (Cl-) corrosion of the alloys, resistance to humidity thermal oxidation corrosion, oilfield water corrosion. The electrochemical corrosion mechanisms of the alloy in oilfield waters are not affected by heat treatment. In simulating oilfield water, the passivity property of the alloy is affected by S2- or HCO3-.
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Djurendić, Evgenija A., Marina P. Zaviš, Marija N. Sakač, Vesna V. Kojić, Gordana M. Bogdanović und Katarina M. Penov Gaši. „Synthesis and Biological Evaluation of Some A,D-Ring Modified 16,17-Secoandrostane Derivatives“. Collection of Czechoslovak Chemical Communications 73, Nr. 5 (2008): 627–36. http://dx.doi.org/10.1135/cccc20080627.
Annotation:
Starting from 3β-hydroxy-17-oxo-16,17-secoandrost-5-ene-16-nitrile (1), the new 16,17-secoandrostane derivatives 2-11 were synthesized. Protection of the 17-oxo function of compound 1 with ethylene glycol yielded compounds 2 and 3. The Oppenauer oxidation of 2 or oxidation with H2O2 in alkaline conditions gave the respective compounds 4 and 10. Epoxidation of compound 4 yielded a mixture of 4α,5α- and 4β,5β-epoxides 5 and 6 and a mixture of 4α,5α- and 4β,5β-epoxy-carboxamides 7 and 8. Opening of the oxirane ring of a mixture of compounds 5 and 6 with formic acid afforded the 4-hydroxy derivative 9. Anti-aromatase activity and in vitro cytotoxicity for three tumor cell lines (human breast adenocarcinoma ER+, MCF-7 as well as human breast adenocarcinoma ER-, MDA-MB-231, and prostate cancer, PC3) of selected compounds were evaluated. Compounds 2, 4, 9, and 10 showed a strong cytotoxicity for PC3 cells.
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Cruz-Gregorio, Alfredo, und Ana Karina Aranda-Rivera. „Quercetin and Ferroptosis“. Life 13, Nr. 8 (11.08.2023): 1730. http://dx.doi.org/10.3390/life13081730.
Annotation:
Quercetin is a flavonoid present in apples, onions, tea, red wines, and berries, and it has shown different beneficial effects, such as providing cardiovascular protection, possessing anti-inflammatory properties, and demonstrating anticancer activity, among others. These diseases are related to oxidizing molecules such as ROS because these species react and induce the oxidation of cellular biomolecules, such as proteins, lipids, DNA, or carbohydrates, which alters cellular homeostasis. Regarding lipids, the oxidation of these molecules induces lipid hydroperoxides which, if not decreased, particularly by GPX4, produce highly reactive aldehydes such as 4HNE and MDA. These oxidative conditions induce ferroptosis, a type of cell death associated with oxidation that differs from other types of cell death, such as apoptosis, necrosis, or autophagy. The induction of ferroptosis is desired in some diseases, such as cancer, but in others, such as cardiovascular diseases, this type of cell death is not wanted. The possible effects of quercetin associated with reducing or inducing ferroptosis have not been reviewed. Thus, this review focuses on the ability of quercetin to produce ferroptosis in diseases such as cancer as a treatment option and, conversely, on its role in deactivating ferroptosis to alleviate diseases such as cardiovascular diseases.
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Emelyanenko, Kirill A., Alexandre M. Emelyanenko und Ludmila B. Boinovich. „Laser Obtained Superhydrophobic State for Stainless Steel Corrosion Protection, a Review“. Coatings 13, Nr. 1 (15.01.2023): 194. http://dx.doi.org/10.3390/coatings13010194.
Annotation:
Stainless steel has become an integral part of modern engineering materials and daily life due to its mechanical efficiency, strength, recyclability, high resistance to oxidation and corrosive attack, which make it the ideal material for many kinds of applications. At the same time, steel suffers from certain types of corrosion, such as intergranular corrosion, or contact corrosion that develops when stainless steel comes into contact with carbon steel or another metal with a different electrochemical potential. Finally, pitting corrosion is a serious problem often occurring when stainless steel parts work in sea water. This paper provides a brief overview of methods for protecting stainless steel from corrosion using a new approach based on superhydrophobization of the surface of stainless steel using laser processing followed by the deposition of a layer of a substance with a low surface energy. The review discusses the mechanisms of corrosion protection by such coatings and the properties of superhydrophobic coatings presented in the literature. Superhydrophobic protective coatings on stainless steel have been shown to significantly reduce corrosion, with some demonstrating a decrease in corrosion current of up to 156 times. However, a more comprehensive analysis of the mechanisms contributing to this effect, as well as a comparison with anti-corrosion coatings on other metals, suggests that the combination of these mechanisms has the potential to create even more durable and effective surfaces for corrosion protection of stainless steel.
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Moore, RB, TM Hulgan, JW Green und LD Jenkins. „Increased susceptibility of the sickle cell membrane Ca2+ + Mg(2+)- ATPase to t-butylhydroperoxide: protective effects of ascorbate and desferal“. Blood 79, Nr. 5 (01.03.1992): 1334–41. http://dx.doi.org/10.1182/blood.v79.5.1334.1334.
Annotation:
Abstract Normal and sickle cell erythrocyte membranes were examined for significant differences in their ATPase activities, thiobarbituric acid reactive products formed (measured relative to malondialdehyde), membrane protein polymerization, and number of protein-free sulfhydryl groups when treated with 0.5 mmol/L t-butylhydroperoxide (tBHP) for 30 minutes. Isolated sickle cell membranes treated with tBHP produced significantly greater inhibition in both their basal and calmodulin- stimulated Ca2+ + Mg(2+)-ATPase activities (75% inhibition in both cases) compared with that of control membranes. In addition, there was significantly more malondialdehyde formed from sickle cell membranes compared with control membranes. Oxidation caused greater protein polymerization in sickle cell membranes compared with normal membranes as demonstrated by the formation of high molecular weight polymers separated on sodium dodecyl sulfate polyacrylamide gels. The number of free sulfhydryl groups present in spectrin and actin decreased more in sickle cell membranes as measured by 3H-N-ethyl maleimide autoradiography and gel scanning. To prevent enzyme inhibition, erythrocyte membranes were treated with tBHP in the presence of 1 mmol/L ascorbate, a potential antioxidant, and 1 mmol/L desferal, an iron chelator. Both ascorbate and desferal added alone with tBHP were effective in preventing inhibition of the basal and calmodulin- stimulated Ca2+ + Mg(2+)-ATPase activities in normal membranes, but in sickle cell membranes only the addition of ascorbate and desferal together offered significant protection. The enhanced oxidation observed with sickle cell membranes can be mimicked in normal white membranes by adding hemoglobin, hemin, or ferrous chloride in the presence of tBHP. In contrast to hemoglobin, ferrous chloride has the ability to enhance membrane oxidation in the presence of ascorbate with or without tBHP. Furthermore, the addition of desferal to these membranes greatly decreased the iron-ascorbate-tBHP oxidation of erythrocyte membranes as determined by the sustained ATPase activities and the reduced formation of malondialdehyde. Maximal protection was provided by 1 mmol/L desferal in the presence of 1 mmol/L ascorbate, although some protection was observed even at 10 mumol/L, the lowest concentration tested. These results are discussed in light of the pro- and anti-oxidant effects of ascorbate in the absence and presence of iron and tBHP.