Zeitschriftenartikel: „Anti-arthritic Properties“

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Bala, Indu, und Pranav Kumar Prabhakar. „Unveiling Therapeutic Prospects: Evaluating the Anti-Arthritic Properties of Thymosin Alpha 1“. Journal of Multidisciplinary Research in Healthcare 10, Nr. 01 (13.10.2023): 13–18. http://dx.doi.org/10.15415/jmrh.2023.101002.

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Background: Thymosin alpha 1 is a peptide naturally occurring in the thymus that has long been recognized for modifying, enhancing, and restoring immune function. Purpose: The present study focuses on the effects of Thymosin alpha 1 on Body weight, Paw weight, paw volume and arthritic score of Collagen induced arthritis (CIA) rats. Methods: The wistar rats were randomly divided into 5 groups: nor-mal control, arthritic control, CIA+Ta-1 0.25mg/kg, CIA+Ta-1 0.5mg/kg and CIA+Ta-1 mg/kg. The collagen and lipopolysaccharide (LPS) were administered via the intraplantar route to the experimental rat subjects. Prior to the administration of collagen and LPS, the initial paw volume was measured, and the body weight was duly document-ed. The administration of the treatment occurred on the first, third, and fifth days. On the completion of the dosing period, specifically on the fifteenth day, the final body weight was duly recorded. The measurements of paw volume, paw weight, Body weight and arthritic score were duly recorded. Results: Following with the administration of Thymosin alpha-1 the arthritic rats shown significantly reduce the severity of arthritis by decreasing the symptoms of arthritis. Conclusions: Thymosin alpha-1 has shown a promising effect of the reduction in the pathophysiology of rheumatoid arthritis and hence it can be a better therapeutic candidate of future for the management of RA. The more detailed analysis of the mechanistic study may provide a better understanding.

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Khandelwal, V., Anita . und T. Sharma. „In vitro Anti-arthritic and Antioxidant properties of the aqueous and ethanolic extracts of Cordia myxa leaves“. Research Journal of Biotechnology 17, Nr. 5 (25.04.2022): 109–14. http://dx.doi.org/10.25303/1705rjbt109114.

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Many plants of Cordia genus are ethanomedically used to treat various diseased conditions like urine infection, leprosy, lung diseases and act as anti-inflammatory, anthelmintic, appetitie suppressant, cough suppressant, diuretic and antimalarial agents. Cordia myxa is one of that traditionally important plants. The aim of the present research is to investigate the chemical composition, antioxidant, anti-arthritic and anti-inflammatory effects of aqueous and ethanolic extracts of Cordia myxa leaves. Phytochemical investigation indicates the presence of alkaloids, phenols, flavanoids etc. responsible for tremendous pharmacological activities. Both the extracts were found to express significant free radical scavenging activity in dose dependent manner with highest 67.87% by aqueous extract. In vitro antiinflammatory and anti-arthritic were also determined where aqueous extract showed maximum inhibition in HRBC membrane lyses with 68.73% inhibition and 72.4% inhibition in protein denaturation which confers potential anti-arthritic activity.

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Alkahtani, Hamad M., Abdulrahman A. Almehizia, Mohamed A. Al-Omar, Ahmad J. Obaidullah, Amer A. Zen, Ashraf S. Hassan und Wael M. Aboulthana. „In Vitro Evaluation and Bioinformatics Analysis of Schiff Bases Bearing Pyrazole Scaffold as Bioactive Agents: Antioxidant, Anti-Diabetic, Anti-Alzheimer, and Anti-Arthritic“. Molecules 28, Nr. 20 (17.10.2023): 7125. http://dx.doi.org/10.3390/molecules28207125.

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In continuation of our research programs for the discovery, production, and development of the pharmacological activities of molecules for various disease treatments, Schiff bases and pyrazole scaffold have a broad spectrum of activities in biological applications. In this context, this manuscript aims to evaluate and study Schiff base–pyrazole molecules as a new class of antioxidant (total antioxidant capacity, iron-reducing power, scavenging activity against DPPH, and ABTS radicals), anti-diabetic (α-amylase% inhibition), anti-Alzheimer’s (acetylcholinesterase% inhibition), and anti-arthritic (protein denaturation% and proteinase enzyme% inhibitions) therapeutics. Therefore, the Schiff bases bearing pyrazole scaffold (22a, b and 23a, b) were designed and synthesized for evaluation of their antioxidant, anti-diabetic, anti-Alzheimer’s, and anti-arthritic properties. The results for compound 22b demonstrated significant antioxidant, anti-diabetic (α-amylase% inhibition), and anti-Alzheimer’s (ACE%) activities, while compound 23a demonstrated significant anti-arthritic activity. Prediction of in silico bioinformatics analysis (physicochemical properties, bioavailability radar, drug-likeness, and medicinal chemistry) of the target derivatives (22a, b and 23a, b) was performed. The molecular lipophilicity potential (MLP) of the derivatives 22a, b and 23a, b was measured to determine which parts of the surface are hydrophobic and which are hydrophilic. In addition, the molecular polar surface area (PSA) was measured to determine the polar surface area and the non-polar surface area of the derivatives 22a, b and 23a, b. This study could be useful to help pharmaceutical researchers discover a new series of potent agents that may act as an antioxidant, anti-diabetic, anti-Alzheimer, and anti-arthritic.

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Belal, Amany, Rehab Mahmoud, Mohamed Taha, Fatma Mohamed Halfaya, Ahmed Hassaballa, Esraa Salah Elbanna, Esraa Khaled et al. „Therapeutic Potential of Zeolites/Vitamin B12 Nanocomposite on Complete Freund’s Adjuvant-Induced Arthritis as a Bone Disorder: In Vivo Study and Bio-Molecular Investigations“. Pharmaceuticals 16, Nr. 2 (13.02.2023): 285. http://dx.doi.org/10.3390/ph16020285.

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Rheumatoid arthritis (RA) is a long-term autoimmune disease. As nanotechnology has advanced, a growing number of nanodrugs have been used in the treatment of RA due to their unique physical and chemical properties. The purpose of this study was to assess the therapeutic potential of a novel zeolite/vitamin B12 nanocomposite (Nano ZT/Vit B12) formulation in complete Freund’s adjuvant (CFA)-induced arthritis. The newly synthesized Nano ZT/Vit B12 was fully characterized using various techniques such as XRD, FT-IR, BET analysis, HERTEM, SEM, practical size, zeta potential, XRF, and EDX. The anti-arthritic, anti-inflammatory, and antioxidant activities as well as the immunomodulation effect of Nano ZT/Vit B12 on the CFA rat model of arthritis were examined. Histopathologic ankle joint injuries caused by CFA intrapedal injection included synovium hyperplasia, inflammatory cell infiltration, and extensive cartilage deterioration. The arthritic rats’ Nano ZT/Vit B12 supplementation significantly improved these effects. Furthermore, in arthritic rats, Nano ZT/Vit B12 significantly reduced serum levels of RF and CRP, as well as the levels of IL-1β, TNF-α, IL-17, and ADAMTS-5, while increasing IL-4 and TIMP-3 levels. Nano-ZT/Vit B12 significantly declined the LPO level and increased antioxidant activities, such as GSH content and GST activity, in the arthritic rats. In arthritic rats, Nano ZT/Vit B12 also reduced TGF-β mRNA gene expression and MMP-13 protein levels. Collectively, Nano ZT/Vit B12 seems to have anti-arthritic, anti-inflammatory, and antioxidant properties, making it a promising option for RA in the future.

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Pereira, Wanderson S., Girlaine P. da Silva, Mariana V. Vigliano, Nathalia R. F. Leal, Fabiana A. Pinto, Daniele C. Fernandes, Shirley V. M. Santos et al. „Anti-arthritic properties of crude extract fromChenopodium ambrosioidesL. leaves“. Journal of Pharmacy and Pharmacology 70, Nr. 8 (30.04.2018): 1078–91. http://dx.doi.org/10.1111/jphp.12926.

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A Meena, R Buvana, A Deepak, P Dinesh Kumar, K Divyapriya und D Duraiarasan. „Preparation and evaluation of anti-arthritic activity of Moringa oleifera leaves extract loaded silver nanoparticles“. International Journal of Scholarly Research and Reviews 2, Nr. 2 (30.06.2023): 096–106. http://dx.doi.org/10.56781/ijsrr.2023.2.2.0023.

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Silver Nanoparticles (Ag-NPs) are increasingly used in various fields including medical, food, healthcare consumer and industrial purposes due to their unique physical and chemical properties. The conventional physical and chemical methods of synthesis of Ag-NPs seem to be very expensive and hazardous. Interestingly, biologically prepared Ag-NPs show high yield, solubility and high stability. The biologically Ag-NPs was characterized by UV-visible spectroscopy and SEM with EDAX. The appearance of specific absorbance peak at 440 nm indicates the presence of Ag-NPs. The development of Ag-NPs as anti-arthritic molecules is one of the most interesting approaches for arthritic treatment as it can overcome poor delivery and the problem of drug resistance. The anti-arthritic activity of developed MO-AgNPs was determined by albumin denaturation assay. MO-AgNPs (Moringa Olifera leaves extract loaded silver nanoparticles) exhibit 25% higher anti-arthritic activity when compared with standard Aspirin drug.

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Belal, Amany, Rehab Mahmoud, Eman E. Mohamed, Ahmed Farghali, Fatma I. Abo El-Ela, Amr Gamal, Fatma Mohamed Halfaya et al. „A Novel Hydroxyapatite/Vitamin B12 Nanoformula for Treatment of Bone Damage: Preparation, Characterization, and Anti-Arthritic, Anti-Inflammatory, and Antioxidant Activities in Chemically Induced Arthritic Rats“. Pharmaceuticals 16, Nr. 4 (06.04.2023): 551. http://dx.doi.org/10.3390/ph16040551.

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The usage of nanomaterials for rheumatoid arthritis (RA) treatment can improve bioavailability and enable selective targeting. The current study prepares and evaluates the in vivo biological effects of a novel hydroxyapatite/vitamin B12 nanoformula in Complete Freund’s adjuvant-induced arthritis in rats. The synthesized nanoformula was characterized using XRD, FTIR, BET analysis, HERTEM, SEM, particle size, and zeta potential. We synthesized pure HAP NPs with 71.01% loading weight percentages of Vit B12 and 49 mg/g loading capacity. Loading of vitamin B12 on hydroxyapatite was modeled by Monte Carlo simulation. Anti-arthritic, anti-inflammatory, and antioxidant effects of the prepared nanoformula were assessed. Treated arthritic rats showed lower levels of RF and CRP, IL-1β, TNF-α, IL-17, and ADAMTS-5, but higher IL-4 and TIMP-3 levels. In addition, the prepared nanoformula increased GSH content and GST antioxidant activity while decreasing LPO levels. Furthermore, it reduced the expression of TGF-β mRNA. Histopathological examinations revealed an improvement in joint injuries through the reduction of inflammatory cell infiltration, cartilage deterioration, and bone damage caused by Complete Freund’s adjuvant. These findings indicate that the anti-arthritic, antioxidant, and anti-inflammatory properties of the prepared nanoformula could be useful for the development of new anti-arthritic treatments.

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Hajare, Pratiksha, Vaishali Rai, Sonali Nipate, Aishwarya Balap, Bhushan Pimple, Deshraj Chumbhale, Asmita Gaikwad und Harshal Tare. „Anti-arthritic potential of ethyl acetate fraction of Pinus roxburghii Sargent stem bark in Freund's complete adjuvant induced arthritis in Wistar rats“. Multidisciplinary Science Journal 5, Nr. 4 (07.06.2023): 2023046. http://dx.doi.org/10.31893/multiscience.2023046.

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Traditional and folk medicine regularly make use of the Pinus roxburghii Sargent (Pinaceae) plant. Unfortunately, there is a lack of data on this plant's potential anti-arthritic effects.Pinus roxburghii Sargent ethyl acetate stem bark has anti-arthritic properties in Wistar rats with arthritis produced by Freund's Complete adjuvant. As a positive control, diclofenac was administered. To define the anti-arthritic activity, the influence on pain perception parameter, haematological parameters, the effect on rheumatoid factor, CRP, and serum parameters were evaluated.In this study, the ethyl acetate fraction of Pinus roxburgii Sargent was found to significantly inhibit pain perception parameters at doses of 250 and 500 mg/kg. Serum levels of RF, NO, and CRP were significantly lower in the Pinus roxburghii Sargent group compared to the disease control group. In disease-free rats, Pinus roxburghii Sargent significantly raised RBC and lowered WBC, both of which point to a suppressive effect on inflammatory mediators. The number of inflammatory cells had decreased, as seen by histopathology. Several imaging parameters, including spur formation, joint spacing, bone erosion, etc., were significantly reduced in a radiological assessment.In this study, authors noted that Pinus roxburghii Sargent had a direct effect on slowing the progression of arthritis, reducing inflammation and synovitis, and protecting arthritic joints from cartilage and bone deterioration. Stem bark extract of Pinus roxburghii Sargent has been shown to have anti-arthritic action based on clinical, biochemical, and histological analysis. Yet more research is required to pin down the precise mechanism of action.

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Nouir, Sahar, Aicha Laouani, Ahmed Loghmari, Khaireddine Bouassida, Raoudha Slim, Rim Bouhajeb, Yosra Hasni, Khaled Saguem, Bouraoui Ouni und Amira Zaïri. „HPLC-DAD Analysis and Investigation of Biological Properties of the Leaves of Globularia alypum (L.), Infusion Extract“. Pharmaceuticals 16, Nr. 12 (14.12.2023): 1726. http://dx.doi.org/10.3390/ph16121726.

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Globularia alypum L. (GA) belonging to the Globulariaceae family is a Mediterranean plant which is widely used in traditional Tunisian medicine. The aim of this study was to investigate the phytochemical composition, antioxidant, anti-arthritic, antiproliferative, antibacterial and antibiofilm potential of aqueous GA leaf extracts (AGAL). Quantitative analyses of the different constituents of extracts were evaluated by high-performance liquid chromatography with photodiode-array detection (HPLC-DAD). Spectrophotometric methods and chemical tests were used for antioxidant and anti-arthritic activities. The antiproliferative study was evaluated using colorectal cancer SW620 cells, while the antibacterial assessment and analysis of the antibiofilm effects were determined by the microdilution method and the crystal violet assay, respectively. AGAL extracts presented several components, mainly Nepetin-7-Glucoside and trans-ferrulic acid. The results showed that they had an important antioxidant (IC50 = 0.34; 0.38 and 1.20 mg/mL) and anti-arthritic (IC50 = 2.94 mg/mL) properties, and these effects are displayed in a dose-dependent manner. In addition, this extract demonstrated significant antiproliferative (IC50 = 50 µg/mL), antibacterial (MIC = 6.25 mg/mL and MBC = 6.25 mg/mL), and antibiofilm (59.70% at 25 mg/mL) properties especially against S. aureus. The results achieved confirm the important role of this plant as a source of therapeutic activities.

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Ticona, Luis Apaza, Andreea Madalina Serban, Daly Apaza Ticona und Karla Slowing. „Anti-inflammatory and Anti-arthritic Activities of Aqueous Extract and Flavonoids from Tripodanthus acutifolius Leaves in Mice Paw Oedema“. Planta Medica International Open 8, Nr. 02 (27.05.2021): e43-e55. http://dx.doi.org/10.1055/a-1471-8947.

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Abstract Tripodanthus acutifolius, commonly known as Jamillo, is an herbal remedy used in traditional Andean medicine to treat joint problems, such as sprains, dislocations, and rheumatic pain. This study aimed to evaluate the in vitro and in vivo anti-inflammatory and anti-arthritic activity of the aqueous extract and isolated compounds of T. acutifolius. A bioguided phytochemical analysis based on NMR/MS was performed to identify the compounds of the aqueous extract from T. acutifolius. The anti-inflammatory and anti-arthritic activity were evaluated by measuring inflammatory parameters (TNF-α, C-reactive protein, and fibrinogen) in murine models. The chemical structure determination led to the identification of four flavonoids: (E)-2’,4’-dihydroxy-6’-methoxy-chalcone (1), 6,2’,4’-trimethoxyflavone (2), 5,3’,4’-trihydroxy-6,7,8-trimethoxyflavone (3), and 5,4’-dihydroxy-6,7,8-trimethoxyflavone (4). All compounds inhibited the production of TNF-α in the RAW 264.7 cell line, with IC50 values of 0.78, 1.43, 5.73, and 9.71 μM, respectively. In addition, all flavonoids decreased the levels of TNF-α, C-reactive protein, and fibrinogen at a concentration of 5 mg/kg in murine models. Our research shows that these compounds isolated from T. acutifolius have anti-inflammatory and anti-arthritic properties, providing scientific evidence for the traditional use of this plant species.

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Faustino, Célia, Noélia Duarte und Lídia Pinheiro. „Triterpenes Drug Delivery Systems, a Modern Approach for Arthritis Targeted Therapy“. Pharmaceuticals 17, Nr. 1 (28.12.2023): 54. http://dx.doi.org/10.3390/ph17010054.

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Arthritis is a major cause of disability. Currently available anti-arthritic drugs, such as disease-modifying anti-rheumatic drugs (DMARDs), have serious side-effects associated with long-term use. Triterpenoids are natural products with known anti-inflammatory properties, and many have revealed efficiency against arthritis both in vitro and in vivo in several animal models, with negligible cytotoxicity. However, poor bioavailability due to low water solubility and extensive metabolism upon oral administration hinder the therapeutic use of anti-arthritic triterpenoids. Therefore, drug delivery systems (DDSs) able to improve the pharmacokinetic profile of triterpenoids and achieve sustained drug release are useful alternatives for targeted delivery in arthritis treatment. Several DDSs have been described in the literature for triterpenoid delivery, including microparticulate and nanoparticulate DDSs, such as polymeric micro and nanoparticles (NPs), polymeric micelles, liposomes, micro and nanoemulsions, and hydrogels. These systems have shown superior therapeutic effects in arthritis compared to the free drugs and are similar to currently available anti-arthritic drugs without significant side-effects. This review focuses on nanocarriers for triterpenoid delivery in arthritis therapy, including osteoarthritis (OA), rheumatoid arthritis (RA) and gout that appeared in the literature in the last ten years.

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Baroroh, Hanif Nasiatul, Esti Dyah Utami und Anisyah Achmad. „Psidium guajava leaves decrease arthritic symptoms in adjuvant-induced arthritic rats“. Universa Medicina 34, Nr. 3 (27.04.2016): 197. http://dx.doi.org/10.18051/univmed.2015.v34.197-204.

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BACKGROUND Guava is an herbal with proven antioxidant and anti-inflammatory properties. The aim of this study was to investigate the anti-arthritic activity of the ethanol extract of Psidium gujava leaves (EEPG) against complete Freund’s adjuvant (CFA) induced arthritis in rats. METHODS An experimental study was conducted on 40 male Wistar Sprague Dawley rats, which were divided into 5 groups. Each group was induced with 0.2 mL CFA (1 mg/mL) on day 1 and 0.1 CFA mL booster injection on day 5. Group I served as an arthritic control, group II received dexamethasone (6.75 mg.kg-1 orally), group III, IV and V received EEPG at oral doses of 250, 500, and 750 mg/kg BW, respectively, on days 14 to 28. Anti-arthritic activity was observed from the arthritis score, the paw circumference was measured on days 0, 1, 4, 8, 12, 16, 20, 24, and 28, the mobility score was determined on days 12 and 28, and the histolopathology of the knee joint was examined on day 29. RESULTS Ethanol extract of Psidium guajava leaves significantly suppressed the swelling of the paws in chronic phase based on increasing of edema (%), while starting on day 20. EEPG at 250 mg/kg was most effective in significantly reducing arthritis scores (p<0.05). Histopathological examination showed repair of the knee joint synovial membrane and cartilage. CONCLUSIONS Psidium guajava leaf extract is effective in decreasing the inflammatory response and arthritic symptoms in rats with adjuvant-induced arthritis. Psidium guajava leaves can be developed into an alternative anti-arthritis treatment.

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PANDYA, Shridhar, Chetan SAVALIYA, Dheeraj NAGORE, Vaishali UNDALE, Shubhada KHADE und Nishant MANTE. „Evaluation of the Effect of Phytocomplex on Chondroprotective Biomarkers in an Experimental Model of Osteoarthritis in Rats“. Medicina Moderna - Modern Medicine 29, Nr. 4 (14.12.2022): 329–37. http://dx.doi.org/10.31689/rmm.2022.29.4.329.

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Osteoarthritis (OA) is most prevalent joint disease and major contributor to non-fatal burden in India, with prevalence rates of 22% - 39%. The use of conventional medication can be associated with insufficient clinical management and serious side effects. The present study aims to evaluate the anti-arthritic activity and chondrocytes protection and regeneration potential of Joint Support Product (JSP) in monosodium Iodoacetate induced Osteoarthritis rat model. Pain threshold, knee joint swelling, Blood inflammatory parameters like Tissue necrosis factor, Interlukin-6, Leukotriene B 4, C- reactive protein and arthritic biomarkers Matrix metalloproteinase-13 and Cartilage Oligomeric Matrix Protein, were estimated. Also Radiographic and histopathological evaluation were done to estimate the severity of OA. Treatment of JSP demonstrated significant increase in pain threshold by 68 % and decrease in knee joint swelling by 92 %. The inflammatory markers decreased significantly (p< .00001) after treatment with JSP. The Tissue necrosis factor decreased by 55 %, Interlukin-6 by 61%, Leukotriene B 4 by 57%, C- reactive protein by 69 % and arthritic biomarkers - Matrix metalloproteinase by 88% and Cartilage Oligomeric Matrix Protein by 37% as compared to disease control rats. Also the radiological evaluation and gross histopathology of rats showed improved chondrocytes structure. Thus JSP’s analgesic, anti-inflammatory, chondrocyte regeneration, and chondroprotective properties have therefore demonstrated an anti-arthritic impact.

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Magari, K., F. Nishigaki, T. Sasakawa, T. Ogawa, S. Miyata, Y. Ohkubo, S. Mutoh und T. Goto. „Anti-arthritic properties of FK506 on collagen-induced arthritis in rats“. Inflammation Research 52, Nr. 12 (01.11.2003): 524–29. http://dx.doi.org/10.1007/s00011-003-1210-8.

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Sathyaseela R, Kamalinie R, Bupesh G, Baskar M und Vasanth S. „Anti Inflammatory effect of Bacopa Monnieri ( Brahmi) on Swollen Joints – A Case Study“. International Journal of Research in Pharmaceutical Sciences 11, Nr. 3 (23.07.2020): 4074–77. http://dx.doi.org/10.26452/ijrps.v11i3.2607.

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The arthritis is a chronic, inflammatory, autoimmune disease characterized by Pain, edema and stiffness of the joints. Chronic stages of arthritis causes swelling in and around the affected joints. The Siddha herbal medicines are becoming familiar as they possess less adverse effects. Plenty of antiinflammatory herbs are described in Siddha system of medicine. The plant, bacopa monnieri maintains its original place in the management of various diseases, including arthritis, and acts as anti-inflammatory drug. Hardly a few studies are available to prove the antiarthritic and anti-inflammatory properties of Bacopa monnieri. In ancient Siddha literature Bacopa has been highlighted for its antiarthritic properties especially prescribed to reduce the swelling caused by increased synovial effusion. The current study is aimed to assess the antiarthritic and anti inflammatory properties of Bacopa (Brahmi) paste on swollen arthritic joints. A male patient aged 70 was selected from IPD, Pothu maruthuvam department, Sri Sairam Siddha Medical College & Research Center, Chennai -44. Bacopa Paste applied over swollen arthritic ankle joints showed good progress in very few days of treatment.

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Ahirwal, Anjali, Swati Bagde, Mayuri Khare und Vinod Singh. „Study of Antinflammatory properties of Lactic Acid Bacteria in experi-mentally induced musculoskeletal symptoms in Wistar Rat“. South Asian Journal of Experimental Biology 3, Nr. 6 (04.01.2014): 319–24. http://dx.doi.org/10.38150/sajeb.3(6).p319-324.

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Rheumatoid Arthritis (RA) is a manifestation of body from multiple causes of weakened immune system, a developed internal allergic response to un-known allergens, hormonal factors, stress and other unknown factors. The present study was undertaken to determine the Anti-arthritic and Anti-inflammatory property of Lactobacillus acidophilus as probiotics against Col-lagen induced arthritis (CIA) in wistar rat. CIA (100μl) was induced intrader-mally at several sites on the back. A dose of L. acidophilus 2 x 108 CFU/ml was administered orally after induction of arthritis i.e. on 7th day. Dexame-thasone was given as standard drug in the dose of 0.3-3.0 mg/kg body weight. Paw thickness was measured and scored regularly. After sacrifice, blood was withdrawn for haematological, biochemical and serological analy-sis. Histopathology of liver, kidney and ovary was also performed. Oral ad-ministration of Lactobacillus significantly decreased the serum ceruloplasmin level. Beneficial effects such as increased adhesive property shown by Lactic Acid Bacteria (LAB), increased haemoglobin content and RBC and decreased WBC counts were observed. High level of C’ Reactive Protein was observed in arthritic control rats. However, L. acidophilus treatment significantly de-creased CRP level. Standard Drug also reduced the CRP level. Similarly Rheu-matoid factor was also decreased in LAB and standard drug group as com-pared to the control. In conclusion LAB has potent anti-arthritic property against and shown reduced level of RF and CRP in collagen induced arthritis in wistar rats.

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Narendhirakannan, R. T., und T. P. Limmy. „Anti-inflammatory and anti-oxidant properties ofSida rhombifoliastems and roots in adjuvant induced arthritic rats“. Immunopharmacology and Immunotoxicology 34, Nr. 2 (04.10.2011): 326–36. http://dx.doi.org/10.3109/08923973.2011.605142.

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Mashaal, Kiran, Arham Shabbir, Muhammad Shahzad, Aisha Mobashar, Tasleem Akhtar, Tabinda Fatima, Bushra Riaz et al. „Amelioration of Rheumatoid Arthritis by Fragaria nubicola (Wild Strawberry) via Attenuation of Inflammatory Mediators in Sprague Dawley Rats“. Medicina 59, Nr. 11 (30.10.2023): 1917. http://dx.doi.org/10.3390/medicina59111917.

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Background and Objectives: Fragaria nubicola has never been evaluated scientifically for its anti-arthritic potential despite its use in folkloric systems of medicine. The research was conducted to assess the potential of F. nubicola against rheumatoid arthritis. Materials and Methods: The current study provided scientific evidence by evaluating the effects of plants using an in vivo CFA-induced model of arthritic rats and subsequent microscopic histopathological evaluation of ankle joints along with the determination of paw edema using a digital water displacement plethysmometer. The study also gave insight by determining levels of pro-inflammatory cytokines, matrix metalloproteinase enzymes (MMPs), prostaglandin E2 (PGE2), nuclear factor kappa B (NF-κB), vascular endothelial growth factor (VEGF), and biochemical and hematological parameters. GCMS analysis was also conducted for the identification of possible anti-inflammatory plant constituents. Results: The data showed that F. nubicola-treated groups attenuated the progression of arthritis and paw edema. Microscopic histopathological evaluation validated the anti-arthritic potential by showing amelioration of bone erosion, infiltration of inflammatory cells, and pannus formation. RT-PCR analysis displayed that treatment with F. nubicola down-regulated IL1β, IL6, TNFα, NF-κB, VEGF, MMP2, MMP3, and MMP9 levels. Moreover, ELISA exhibited a reduction in levels of PGE2 levels in treatment groups. The levels of RBCs, platelets, WBCs, and Hb content were found to be nearly similar to negative control in the treated group. Statistically, a non-significant difference was found when all groups were compared for urea, creatinine, ALT, and AST analysis, indicating the safety of plant extract and fractions at test doses. GCMS analysis of extract and fractions showed the existence of many anti-inflammatory and antioxidant phytochemicals. Conclusion: In conclusion, F. nubicola possessed anti-arthritic properties that might be attributed to the amelioration of MMPs and pro-inflammatory cytokines.

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Thuy, Trinh Thi, Tran Duc Quan, Nguyen Thanh Tam, Nguyen Thi Hoang Anh, Nguyen Thi Cuc, Nguyen Thi Nga, Tran Van Sung et al. „INVESTIGATING THE ANTI-INFLAMMATORY ACTIVITY OF AN ETHANOLIC EXTRACT FROM ARTOCARPUS TONKINENSIS LEAVES USING A COLLAGEN ANTIBODY-INDUCED ARTHRITIC MOUSE MODEL“. Vietnam Journal of Science and Technology 56, Nr. 3 (11.06.2018): 286. http://dx.doi.org/10.15625/2525-2518/56/3/11105.

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The obtained results here demonstrate that the 70% ethanolic leaf extract of A. tonkinensis (AT2), traditionally used in Vietnamese folk medicine for treating arthritic symtoms, has beneficial effects on pro-inflammatory cytokine inhibition and in an experimental arthritic mouse model. LPS-stimulated RAW 264.7 macrophages treated with AT2 showed a significant decrease in the production of IL-6 and TNFa at concentrations of 12.5, 25 and 50 µg/mL (P<0.05), indicating its potential anti-inflammatory properties. Treatment of CAIA mice with AT2 also led to diminish the incidence of arthritis at doses of 200 and 300 mg/kg body weight.

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Mehdi, Quratulain. „Efficacy of Telmisartan in Pristane Induced Arthritis Rat Model“. Proceedings of Shaikh Zayed Medical Complex Lahore 35, Nr. 3 (26.06.2021): 6–11. http://dx.doi.org/10.47489/pszmc-801-35-3-6-11.

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Introduction: Rheumatoid arthritis is one of the most common systemic inflammatory diseases characterized by progressive damage to the joints. There is rising evidence that Renin Angiotensin Aldosterone System signaling is also involved in the inflammatory response in rheumatoid arthritis and its blockers possess anti-arthritic properties. Telmisartan is an angiotensin receptor blocker and PPAR-? agonist and its anti-arthritic effects were evaluated. Aims & Objectives: This experimental study was designed to evaluate the anti-arthritic efficacy of telmisartan in pristane induced rat model of arthritis in adult female rats. Place and duration of study: The study was conducted in the Department of Pharmacology, Army Medical College, Rawalpindi, in collaboration with National Institute of Health and Armed Forces Institute of Pathology from July 2020 to August 2020. Material & Methods: Twenty four (24) adult non-pregnant female Sprague Dawley rats were divided in three groups (n=8) designated as Group A (normal control), Group B (arthritic control) and Group C (telmisartan group) & maintained on standard diet and water adlibitum. Rheumatoid arthritis was induced in each rat of Groups B &C by a single intradermal injection of 0.5ml pristane at the base of its tail on day 0 and the disease developed in two weeks. All 3 groups were given distilled water 2.5 ml/kg from 2-4 weeks and Group C was additionally given dissolved telmisartan orally at 2 mg/kg/day. Anti-arthritic efficacy was determined by assessing arthrogram score and total leukocyte count on day 0, 14 and 28 along with histological examination done at the end of the study. Data analysis was done using SPSS version 25. Results: Healthy rats in group A maintained a unremarkable arthogram & histogram score & TLC count of 6675±350/?l during the entire study period. Telmisartan administration in Group C for two weeks after pristane induction resulted in significant reduction in arthrogram score (AS) 9.5±3.66, total leukocyte count (TLC) 7350±550/?l and histological score (HS) to 6.88±1.24 as compared to (AS) 14.50±2.07, WBC 10150±350/?L & (HS) 10.75±2.05 in Group B, left untreated with pristane alone. The intergroup comparison showed significant p value < 0.05 respectively. Conclusion: Anti-arthritic effect was shown by telmisartan as it was able to ameliorate the changes induced by pristane.

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Maroyi, Alfred. „Review Article: Medicinal uses, phytochemistry, pharmacology and toxicological properties of Elaeodendron croceum“. Tropical Journal of Pharmaceutical Research 18, Nr. 3 (14.05.2021): 669–76. http://dx.doi.org/10.4314/tjpr.v18i3.30.

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Elaeodendron croceum is a shrub or a small tree used as an emetic, purgative and herbal medicine for cough, sore throat, fever, tuberculosis, blood in sputum, chest congestion, human immunodeficiency virus (HIV) opportunistic infections and to clean the digestive tract. Phytochemical compounds identified from the species include alkaloids, cardiac glucoside, flavonoids, phenols, proanthocyanidins, saponins, sugars, tannins and triterpenoids. Pharmacological studies revealed that E. croceum extracts and compounds have antimycobacterial, anti-arthritic, antibacterial, anti-HIV, antioxidant, anti-inflammatory, antifungal and cytotoxicity activities. Future studies should focus on ethnopharmacological safety and efficacy of E. croceum extracts and compounds isolated from the species using in vivo preclinical studies and clinical trials.

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Punjabi, C. J., D. D. Wood und P. H. Wooley. „A monoclonal anti-type II collagen antibody with cross-reactive anti-Ig activity specific for the F(ab')2 fragment.“ Journal of Immunology 141, Nr. 11 (01.12.1988): 3819–22. http://dx.doi.org/10.4049/jimmunol.141.11.3819.

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Abstract An IgG2a hybridoma antibody (BC-10) was obtained by a myeloma fusion with lymphocytes from B10.RIII mice immunized against native bovine type II collagen. This anti-collagen monoclonal exhibited extensive cross-reactivity with several type II collagen species. BC-10 was found to have self-associating properties, but not the specificity of a typical IgG rheumatoid factor, inasmuch as this mAb bound to F(ab')2 fragments of itself and of normal mouse IgG. Self binding was inhibited by the association of BC-10 with type II collagen, and inhibition assays indicated that antibodies with the capacity to inhibit BC-10 binding to collagen were present in the sera from B10.RIII arthritic mice, but not from DBA/1 LacJ arthritic mice. Joint inflammation and histopathologic features consistent with arthritis were observed in mice injected with the BC-10 hybridoma.

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Paul, Subhashis, Sudeb Sarkar, Tanmoy Dutta und Soumen Bhattacharjee. „Assessment of anti-inflammatory and anti-arthritic properties of Acmella uliginosa (Sw.) Cass. based on experiments in arthritic rat models and qualitative GC/MS analyses.“ Journal of Intercultural Ethnopharmacology 5, Nr. 3 (2016): 257. http://dx.doi.org/10.5455/jice.20160521010145.

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Cheruku, Gowtham Reddy, Pavani Anumula, Divya Jyothi GSV, Tejaswini SS Oruganti und Akhil Babu Gangi. „Phytochemical evaluation and Pharmacological screening of Cuscuta reflexa roxburg on anti-arthritic activity“. Journal of Phytopharmacology 10, Nr. 6 (25.12.2021): 510–13. http://dx.doi.org/10.31254/phyto.2021.10614.

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Cuscuta reflexa Roxb, a rootless, leafless, twining annual parasite with a wide variety of species, is an extensive climber found in temperate and tropical regions. It is widely used in Ayurvedic (traditional medicine native to the Indian subcontinent) medicine to relieve and treat many diseases. There are numerous countries in which it is widely used for treating urination disorders, bilious disorders, diabetic disorders, and inflammatory diseases, including Afghanistan, Malaysia, India, and China. The aim of this study is to demonstrate the anti-inflammatory and antiarthritic properties of the methanolic extract of Cuscuta reflexa Roxburg. A variety of phytoconstituents are found in it, such as alkaloids, tannins, coumarins, phenolic compounds, flavonoids, and saponins. These phytoconstituents are screened by various conformation tests. The anti-inflammatory properties were evaluated in vivo in rats using CFAComplete Fruend’s adjuvant induced polyarthritis model. This study shows that methanolic extract at a concentration of 400mg/kg inhibits arthritic activity. This result was compared with the standard drug, prednisolone 5mg/kg. The anti-arthritic activity of Cuscuta reflexa Roxberg was evaluated by considering paw volume, paw thickness and body weight. Visual criteria were used to monitor the morphological features of arthritis such as redness, swelling, erythema. The scores were recorded during these specific days of the project- 1, 4, 10, 14, 17 and 21. The test compound at 200mg/kg doesn’t show any anti-arthritic property, but at the dose of 400mg/kg it proved its significant action to reduce the inflammation and pain induced by complete Freund's Adjuvant (CFA). Based on the systemic analysis, the extract maintained normal joint parameters and greatly restored the normal architecture of the joints in animals. Thus, Cuscuta reflexa Roxburg would be an interesting source for antiarthritic activity.

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Gupta, Anuradha, Jungmi Lee, Torsha Ghosh, Van Quy Nguyen, Anup Dey, Been Yoon, Wooram Um und Jae Hyung Park. „Polymeric Hydrogels for Controlled Drug Delivery to Treat Arthritis“. Pharmaceutics 14, Nr. 3 (28.02.2022): 540. http://dx.doi.org/10.3390/pharmaceutics14030540.

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Rheumatoid arthritis (RA) and osteoarthritis (OA) are disabling musculoskeletal disorders that affect joints and cartilage and may lead to bone degeneration. Conventional delivery of anti-arthritic agents is limited due to short intra-articular half-life and toxicities. Innovations in polymer chemistry have led to advancements in hydrogel technology, offering a versatile drug delivery platform exhibiting tissue-like properties with tunable drug loading and high residence time properties This review discusses the advantages and drawbacks of polymeric materials along with their modifications as well as their applications for fabricating hydrogels loaded with therapeutic agents (small molecule drugs, immunotherapeutic agents, and cells). Emphasis is given to the biological potentialities of hydrogel hybrid systems/micro-and nanotechnology-integrated hydrogels as promising tools. Applications for facile tuning of therapeutic drug loading, maintaining long-term release, and consequently improving therapeutic outcome and patient compliance in arthritis are detailed. This review also suggests the advantages, challenges, and future perspectives of hydrogels loaded with anti-arthritic agents with high therapeutic potential that may alter the landscape of currently available arthritis treatment modalities.

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Djehiche, Cheima, Nadia Benzidane, Hanene Djeghim, Mehdi Tebboub, El Hassen Mokrani, Saad Mebrek, Mohammed Messaoudi et al. „Exploring the Therapeutic Potential of Ammodaucus leucotrichus Seed Extracts: A Multi-Faceted Analysis of Phytochemical Composition, Anti-Inflammatory Efficacy, Predictive Anti-Arthritic Properties, and Molecular Docking Insights“. Pharmaceuticals 17, Nr. 3 (18.03.2024): 385. http://dx.doi.org/10.3390/ph17030385.

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Ammodaucus leucotrichus exhibits promising pharmacological activity, hinting at anti-inflammatory and anti-arthritic effects. This study investigated seed extracts from Ammodaucus leucotrichus using methanol and n-hexane, focusing on anti-inflammatory and anti-arthritic properties. The methanol extract outperformed the n-hexane extract and diclofenac, a reference anti-inflammatory drug, in trypsin inhibition (85% vs. 30% and 64.67% at 125 μg/mL). For trypsin inhibition, the IC50 values were 82.97 μg/mL (methanol), 202.70 μg/mL (n-hexane), and 97.04 μg/mL (diclofenac). Additionally, the n-hexane extract surpassed the methanol extract and diclofenac in BSA (bovine serum albumin) denaturation inhibition (90.4% vs. 22.0% and 51.4% at 62.5 μg/mL). The BSA denaturation IC50 values were 14.30 μg/mL (n-hexane), 5408 μg/mL (methanol), and 42.30 μg/mL (diclofenac). Gas chromatography–mass spectrometry (GC–MS) revealed 59 and 58 secondary metabolites in the methanol and n-hexane extracts, respectively. The higher therapeutic activity of the methanol extract was attributed to hydroxyacetic acid hydrazide, absent in the n-hexane extract. In silico docking studies identified 28 compounds with negative binding energies, indicating potential trypsin inhibition. The 2-hydroxyacetohydrazide displayed superior inhibitory effects compared to diclofenac. Further mechanistic studies are crucial to validate 2-hydroxyacetohydrazide as a potential drug candidate for rheumatoid arthritis treatment.

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Sattar, Sara, Arham Shabbir, Muhammad Shahzad, Tasleem Akhtar, Arfan Ahmad, Sulaiman Mohammed Alnasser, Bushra Riaz, Shaik Karimullah und Ashfaq Ahmad. „Eichhornia crassipes Ameliorated Rheumatoid Arthritis by Modulating Inflammatory Cytokines and Metalloproteinase Enzymes in a Rat Model“. Medicina 59, Nr. 9 (04.09.2023): 1594. http://dx.doi.org/10.3390/medicina59091594.

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Background and Objectives: This study was planned to investigate the anti-arthritic property of flowers of E. crassipes in a Sprague–Dawley rat model by administering Freund’s Complete Adjuvant (FCA). Materials and Methods: Arthritis was induced at day 0 in all rats except negative controls, while arthritic progress and paw edema were analyzed on specific days (8th, 13th, 18th, and 23rd) via the macroscopic arthritic scale and a digital Vernier caliper, respectively. Histopathological parameters were examined using a Hematoxylin and Eosin (H&E) staining method. Blood samples were withdrawn from rats to investigate the effects of the E. crassipes flower on the mRNA expression values of inflammatory markers, via a reverse transcription PCR technique. Serum samples were used to determine prostaglandin E2 (PGE2) levels using enzyme-linked immunosorbent assay (ELISA). Values of alanine transaminase (ALT), aspartate aminotransferase (AST), creatinine, and urea, besides hematological parameters, i.e., the hemoglobin (Hb) content and complete blood count (CBC), were investigated. Results: The data showed that E. crassipes inhibited the arthritic progress and ameliorated the paw edema. The amelioration of parameters assessed via the histopathological analysis of ankle joints, as well as via hematological analysis, confirmed the diminution of rheumatoid arthritis (RA) in the plant-treated groups. Treatment with E. crassipes inhibited the expression levels of tumor necrosis factor-α (TNF-α), interleukins (IL-1β and IL-6), nuclear factor KappaB (NF-κB), matrix metalloproteinase (MMP-2 and MMP-3), and vascular endothelial growth factor (VEGF). Serum PGE2 levels were also found to be reduced in treatment groups. A biochemical investigation revealed the improvements in hepatic markers in plant-treated groups. The data indicated that the plant has no hepatotoxic or nephrotoxic effects at the studied dose. GC-MS (Gas Chromatography-Mass Spectrometry) analysis displayed the presence of phytochemicals having known anti-inflammatory and antioxidant properties. Conclusions: Therefore, it may be concluded that E. crassipes possesses anti-arthritic characteristics that could be attributed to the modulation of pro-inflammatory cytokines, MMPs, and PGE2 levels.

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Singh, Ajeet, und Navneet. „Ethnomedicinal, Pharmacological Properties and Phytochemistry of Sida spinosa Linn. A mini review“. Journal of Phytopharmacology 7, Nr. 1 (22.01.2018): 88–91. http://dx.doi.org/10.31254/phyto.2018.7118.

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The comprehensive survey information as provided in this review on Sida spinosa Linn traditional uses, ethanobotanical aspects, phytochemistry and pharmacology. The plant has a variety of traditional uses. Leaves are reported to possess demulcent, refrigerant properties, and are useful in cases of gonorrhoea, gleet and scalding urine. They are bruised in water and the filtrate is administered. Root is used as a tonic and diaphoretic and is given in mild cases of debility and fever. A decoction of it is said to be given as a demulcent in irritability of bladder and in gonorrhoea. Decoction given as a demulcent in irritability of bladder and genitourinary tract. Leaves are used as demulcent and refrigerant; used for scalding urine. Sida spinosa possesses various traditional and pharmacological properties includes antibacterial, antifungal, anti-helmintic, anti-fertility, antidiabetic, anti-inflammatory, antioxidant, anti-HIV, anti-arthritic, cytoprotective, hepatoprotective, anti-diarrhoeal and analgesic activities of Sida spinosa

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Mbiantcha, Marius, Marcelle Bejoutance Djami, Gilbert Ateufack, Donatien Albert Atsamo, Gonzal Eric Tsafack, William Nana Yousseu, Flore Stéphanie Nguemnang Djuichou et al. „Anti-inflammatory and anti-arthritic properties of aqueous extract of Nauclea diderrichii (Rubiaceae) stem bark in rats“. Advances in Traditional Medicine 20, Nr. 2 (15.05.2020): 199–212. http://dx.doi.org/10.1007/s13596-020-00446-6.

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Zhang, Maoquan, Baolong Liu und Zonghui Ji. „Effect of Wu-Wei-Gui-Shao decoction on complete Freund's adjuvant-induced arthritis rats“. Tropical Journal of Pharmaceutical Research 19, Nr. 9 (24.11.2020): 1977–83. http://dx.doi.org/10.4314/tjpr.v19i9.25.

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Purpose: To investigate the anti-rheumatic potential of Wu-Wei-Gui-Shao decoction (WGD) and its possible mechanism of action. Methods: Adjuvant arthritis (AA) rats were established using complete Freund's adjuvant. The rats were then given different doses of WGD (100, 200, and 400 mg/kg, for 28 days). The anti-arthritic effects of WGD were evaluated. Furthermore, the in vitro anti-arthritic effects of WGD and its related mechanisms were also determined in MH7A cells. Results: WGD (100 - 400 mg/kg) exhibited significant anti-rheumatic properties after 28 days of treatment, inhibiting paw edema in AA rats, reducing arthritis score and thymus and spleen index, and inhibiting the tumor necrosis factor (TNF)-α and the interleukin (IL)-6. In addition, the results of in vitro cell experiments also confirmed that WGD reduced the release of cytokines, as well as mRNA levels of matrix metalloproteinase (MMP) -2, -3, and -9. Conclusion: These findings suggest that WGD can be further developed as a traditional Chinese medicine to treat rheumatic arthritis. Keywords: Wu-Wei-Gui-Shao decoction, Complete Freund's adjuvant, Arthritis, Molecular mechanism, Traditional Chinese Medicine

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Ololade, ZS, OO Ogunmola, SE Kuyooro und OO Abiona. „Stachytarpheta jamaicensis leaf extract: Chemical composition, antioxidant, anti-arthritic, anti-inflammatory and bactericidal potentials“. Journal of Scientific and Innovative Research 6, Nr. 4 (30.12.2017): 119–25. http://dx.doi.org/10.31254/jsir.2017.6401.

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Stachytarpheta jamaicensis is an important plant with multi therapeutic properties. Hence, this study seeks to screen the leaf extract of S. jamaicensis for its chemical composition and pharmacological activities in order to find possible sources for novel phytochemicals in food and pharmaceutical formulations. The chemical composition, pH, TPC, TFC, TTC, TAA, carotenoid, antioxidant, anti-arthritic, anti-inflammatory and bactericidal potential were measured using GC-MS, pH meter, Folin-Ciocalteu’s, AlCl3, FeCl3/gelatine, 2,4- DNPH, acetone-hexane, DPPH, PTAC, BSA and agar-well diffusion methods respectively. The pH of the aqueous solution was 6.02. The GC and GC-MS analyses revealed the presence of 30 organic compounds. The most abundant components were 3,5-dihydroxy-6-methyl-2,3-dihydro-4H-pyran-4-one (13.7%), D-arabinitol (13.5%), 2-benzylidenemalonic acid (11.9%), 1,3-cyclopentadione (8.9%), α-5-ethyl-2-furylglycine (6.8%), 4,5-dihydro-5-methoxy-4-(2,3-dimethyl-2-buten-4-yl)-2(3H)-furanone (6.4%) and 3-methyl-2H-indazol-2-ol (5.8%). The TPC, TFC, TTC, TAA, β-carotene and lycopene values were 31,882.80 ±0.00 µgmg-1 GAE, 29.29±0.00 µgmg-1 QE, 126.47 µgmg-1 TAE, 53.75±0.01 µgmg-1 AAE, 0.17 mgg-1 and 0.14 mgg-1 , respectively. The antioxidant IC50 and AAI values of the leaf extract were 5.0 µgml-1 and 8.0. The extract was capable of scavenging free radicals in a range between 51.30-78.99%. The PTAC value was 396.15±0.00 µgmg-1 AAE. The extract also gave high egg albumin and BSA anti-arthritic/anti-inflammatory values between 22-80% with IC50 values of 0.04 and 0.15 mgml-1 , respectively. The extract was active against all the tested bacteria with high zones of inhibition (14.0-25.0 mm). These results showed that the leaf extract of S. jamaicensis could be used for the formulation of active compounds with broad activities for food and pharmaceutical industries.

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Chis, Irina C., Doina Baltaru, Simona Clichici, Ovidiu Oniga, Ileana Cojocaru und Cristina Nastasa. „The Effects of a 5-Chromene-yl-thiazolidin-2,4-dione Derivative in Alleviating Oxidative Stress in Adjuvant-Induced Arthritis“. Revista de Chimie 69, Nr. 9 (15.10.2018): 2361–65. http://dx.doi.org/10.37358/rc.18.9.6534.

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Rheumatoid arthritis (RA) is a chronic inflammatory disease that reduces life quality and requires long-life therapy. Quercetin (Que) is a natural flavonoid with antioxidant and anti-inflammatory effects. (3-(2-(4-Chlorophenyl)-2-oxoethyl)-5-((6-methyl-4-oxo-4H-chromen-3-yl)methylene) thiazolidine-2,4-dione (TZD) is a thiazolidinedione derivative synthesized in our laboratory. This study was designed to investigate the antioxidant effects of the Que and TZD derivative administration in adjuvant-induced arthritic (AIA) rats. AIA was induced in Wistar rats by the intraplantar injection of Freund�s complete adjuvant (FCA), unilaterally in the right hind paw. The control non-arthritic rats and the arthritic rats were treated with Que (30 mg/kg/day) or TZD derivative (12 mg/kg/day) for 21 days. The antioxidant effects of 5-chromen-yl- thiazolidinedione were compared to Que. The serum levels of malondialdehyde (MDA) and protein carbonyl (PC) groups, the superoxide dismutase (SOD) and catalase (CAT) activity were assessed. AIA rats showed significatly increased oxidative stress parameter levels in the blood. The results indicated that the TZD derivative decreased the blood oxidative stress parameters in the treated arthritic rats, compared to Que. The antioxidant effects of 5-chromen-yl-thiazolidinedione in AIA suggest its therapeutic properties for the clinical treatment of RA.

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Roumil, Imene, Wafa Cheniti, Abderrahmane Baghiani, Noureddine Charef und Lekhmici Arrar. „HPLC Analysis, Acute toxicity and Assessment of Antioxidant and Anti-inflammatory Capacity of different Extracts of Equisetum arvense“. South Asian Journal of Experimental Biology 12, Nr. 3 (28.05.2022): 318–26. http://dx.doi.org/10.38150/sajeb.12(3).p318-326.

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Equisetum arvense, a medicinal plant belonging to the family of Equisetaceae, is used in the fight against infectious or inflammatory diseases. The aim of this research was to assess the acute oral toxicity, to identify some phenolic acids and flavonoids by HPLC analysis, and to evaluate the antioxidant and the anti-inflammatory activities of E. arvense methanol extract (EAME) and aqueous (EAQE) extracts. The acute toxicity study was carried out using Swiss albino mice. Animals were observed during 14 days and signs of toxicity were controlled, afterwards, mice were sacrificed for biochemical studies. HPLC method was used to analyze E. arvense extracts. Antioxidant activity was determined using DPPH, reducing power, free hydroxyl radicals assays and antihemolytic activity. Xylene-induced ear edema in mice and carrageenan-induced paw edema in rat were used to evaluate anti-inflammatory activity. Formaldehyde-induced paw edema was used to assess anti-arthritic effect of extracts. In the acute toxicity study, both extracts did not engender any mortality or changes in general behaviors of tested animals. The LD50 was found to be superior to 5000 mg/kg DW. Extracts, rich in polyphenols and/or flavonoids, showed high antioxidant activity. Both extracts showed significant anti-inflammatory and anti-arthritic effects on animal models. These results revealed that E. arvense extracts can be a valuable source of phenolic compounds and flavonoids with powerful antioxidant and anti-inflammatory properties.

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Pal, Rashmi Saxena, Yogendra Pal, Pranay Wal und Ankita Wal. „Standardization and Detailed Aspects of Chopchinyadi Churna: A Potent Anti-Arthritic Medicine“. Open Medicine Journal 6, Nr. 1 (30.04.2019): 19–25. http://dx.doi.org/10.2174/1874220301906010019.

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Background: Chopchinyadi Churna is a powdered Ayurvedic churna, commonly used for treating insect bite, rheumatoid arthritis, gout arthritis. Objective: The current research is oriented for the evaluation of ingredients and other aspects of Churna. Materials and Methods: The Churna was standardized as per the parameters of Ayurvedic Formulary of India for the organoleptic characters, microscopy, physicochemical, chromatographic, rheological properties and phytochemical screening for the detection of major phytoconstituents. Results: The parameters were found to be significant and offered future benefits for the advanced evaluation of Churṇa. Conclusion: Herbal based anti-arthritic medicine Chopchinyadi Churna has been evaluated on the basis of various parameters, which can serve as references for developing the pharmacopoeial standards.

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Małek, Agata, Maciej Strzemski, Joanna Kurzepa und Jacek Kurzepa. „Can Bee Venom Be Used as Anticancer Agent in Modern Medicine?“ Cancers 15, Nr. 14 (21.07.2023): 3714. http://dx.doi.org/10.3390/cancers15143714.

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Honey bee venom in its composition contains many biologically active peptides and enzymes that are effective in the fight against diseases of various etiologies. The history of the use of bee venom for medicinal purposes dates back thousands of years. There are many reports in the literature on the pharmacological properties of bee venom and/or its main components, e.g., anti-arthritic, anti-inflammatory, anti-microbial or neuroprotective properties. In addition, both crude venom and melittin exhibit cytotoxic activity against a wide range of tumor cells, with significant anti-metastatic activity in pre-clinical studies. Due to the constantly increasing incidence of cancer, the development of new therapeutic strategies in oncology is a particular challenge for modern medicine. A review paper discusses the various properties of bee venom with an emphasis on its anticancer properties. For this purpose, the PubMed database was searched, and publications related to “bee”, “venom”, “cancer” from the last 10 years were selected.

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Hsieh, I.-N., J.-P. Liou, H.-Y. Lee, M.-J. Lai, Y.-H. Li und C.-R. Yang. „Preclinical anti-arthritic study and pharmacokinetic properties of a potent histone deacetylase inhibitor MPT0G009“. Cell Death & Disease 5, Nr. 4 (April 2014): e1166-e1166. http://dx.doi.org/10.1038/cddis.2014.133.

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Ferdosh, Sahena. „The Extraction of Bioactive Agents from Calophyllum inophyllum L., and Their Pharmacological Properties“. Scientia Pharmaceutica 92, Nr. 1 (09.01.2024): 6. http://dx.doi.org/10.3390/scipharm92010006.

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Calophyllum inophyllum L. has been used for many generations by Pacific Islanders because of its numerous health and aesthetic advantages. The leaves, stems, roots, fruits, flowers, and seeds of this plant contain significant phytochemicals, including flavonoids, coumarins, fatty acids, and xanthones, which have been shown to have wound healing, analgesic, anti-inflammatory, antiaging, anti-arthritic, anti-cancer, anti-proliferative, anti-diabetic, anti-microbial, and anti-HIV effects. The chemical profiles and bioactive potential may vary due to different extraction techniques, plant parts, and geographical origins. Extraction is the essential first step in the analysis of bioactive compounds that leads to further separation, identification, and characterization. Conventional methods like maceration, Soxhlet, and percolation are often used to extract bioactive compounds from C. inophyllum. However, little study has been carried out on non-conventional methods such as pressured liquid extraction, supercritical fluid extraction (SFE), and ultrasound-assisted extraction. The SFE method can be used to extract bioactive compounds from C. inophyllum to retain their pharmacological properties for application in pharmaceutical and cosmetic products.

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C K, Amritha, Suma C, Ananya V M, Thushara P V und Deepak V S. „PHYTOCHEMICAL AND PHARMACOLOGICAL ACTIVITIES OF JUSTICIA PROCUMBENS L.: A REVIEW“. International Journal of Research in Ayurveda and Pharmacy 11, Nr. 5 (30.10.2020): 190–93. http://dx.doi.org/10.7897/2277-4343.1105167.

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Justicia procumbens L. is usually known as water willow which belongs to family Acanthaceae growing widely in southern regions of China, Japan, Vietnam, India and Australia. It is one of the important herbal being used in Ayurvedic system of medicine. The plant contains various active compounds like arylnaphthalide and diarylbutane lignans, glycosides, flavonoids. Few pharmacological properties including anti-inflammatory, anti-arthritic, anti-arrhythmic, anti-asthmatic, anti-proliferative, anti-allergic, antibacterial, cytotoxic and anti-HIV activities activity have been reported for this plant. Conventionally, it is used for the treatment of fever, inflammation, cold, cough, asthma, cancer, snake bites etc. The current review is created with an intended to focus on the numerous ethnobotanical and traditional uses as well as the phytochemical and pharmacological report on Justicia procumbens.

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Cruz de Oliveira Jr., Pedro, Eloise Balen, Jucicleia da Silva Arrigo, Anelise Samara Nazari Formagio, Marciane Maximo da Silva und Candida Aparecida Leite Kassuya. „Analgesic effect of methanolic extract obtained from Schinus terebinthifolius leaves“. Biomedical and Biopharmaceutical Research Journal 17, Nr. 2 (Juli 2020): 1–12. http://dx.doi.org/10.19277/bbr.17.2.234.

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Previous studies from our group showed the analgesic effects of essential oil and extracts of Schinus terebinthifolius. The aims of this research were to evaluate the anti-nociceptive, anti-arthritic properties of methanolic extract obtained from S. terebinthifolius (MEST) leaves in animal models of experimental pain and arthritis. The MEST (30 and 100 mg/kg) reduced both phases of formalin induced licking behavior in Swiss mice. The MEST (100 mg/kg) reduced mechanical hyperalgesia induced by carrageenan in swiss mice. The MEST (100 mg/kg) oral administration reduced significantly the mechanical hyperalgesia (day 2, 5, 10, and 20), knee oedema (day 2), cold (day 15) and heat sensitivity (day 20), but not depressive-like behavior (Forced Swim Test), after Complete Freund's Adjuvant (CFA) in C57B16 mice. The MEST prevented the anti-nociceptive effects in formalin nociception and did not interfere with locomotor activity in Swiss mice (open field test). The MEST was effective for the inhibition of pain and arthritic parameters without altering locomotor activity or depressive-like behavior. The present results may open new possibilities for the development of new analgesic agents from S. terebinthifolius.

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Ribeiro, Rachel Melo, Emanoel Ribeiro De Brito Junior, Mateus Balbino Barbosa De Carvalho, Beatriz da Silva Ferreira De Lima, Lara Possapp Andrade, Gabriel Antônio Bezerra Costa E Souza, Jhônata Costa Moura und Ellen Caroline da Silva Penha. „Dysphania ambrosioides: phytochemical composition and pharmacological potential of the leaves“. Brazilian Journal of Health Review 6, Nr. 4 (18.08.2023): 18067–84. http://dx.doi.org/10.34119/bjhrv6n4-315.

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Dysphania ambrosioides (Amaranthaceae), popularly known as "mastruz" in Brazil, it is a medicinal plant traditionally used in herbal medicines for treatment of diseases in various regions of the world. This study aimed to review the pharmacological properties of D. ambrosoides leaves. D. ambrosioides is a promising ethnomedicinal plant and its leaves are a source of bioactive compounds, and biological potential such anti-inflammatory, gastroprotective, hypotensive, anti-arthritic, antiparasitic, antioxidant, antitumor, and antifertility effect. Recent studies evidence, still, the action of this plant on wound healing and bone metabolism, observing promising results as a bone graft.

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Khan, Mahmood Ahmad, Rafat Sultana Ahmed, Nilesh Chandra, Vinod Kumar Arora und Athar Ali. „In vivo, Extract from Withania somnifera Root Ameliorates Arthritis via Regulation of Key Immune Mediators of Inflammation in Experimental Model of Arthritis“. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 18, Nr. 1 (06.02.2019): 55–70. http://dx.doi.org/10.2174/1871523017666181116092934.

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Background: Rheumatoid Arthritis (RA) is a devastating disease characterized by continual addition of leukocytes and T cells within the articular cavity causing inflammation and cartilage destruction. Withania somnifera is one of the most precious medicinal herbs, reported to have antioxidant, anti‐inflammatory, and immunomodulatory properties. Objective: The purpose of this study was to evaluate anti-inflammatory activity of aqueous extract of Withania somnifera roots (WSAq) in Collagen Induced Arthritic (CIA) rats. Methods: To achieve this, we assessed the level of inflammatory cytokines such as Tumor Necrosis Factor (TNF)-α, IL-1β, IL-6 and IL-10 in CIA rats. Further, transcription factor, oxidative stress parameters and CD+8 expressions were also analyzed in CIA rats. Results: Arthritic rats showed a greater increase in the levels of pro inflammatory cytokines such as TNF-α, IL-1β, IL-6, transcription factor NF-κB and a decrease in IL-10 concentration than controls rats. Oral administration of WSAq at a dose of 300mg/kg.wt. (WSAq300) appreciably attenuated the production of these pro inflammatory cytokines. This anti-inflammatory activity of WSAq300 might be partly mediated through an increase in the secretion of IL-10 and inhibition of NF-κB activity. Further, arthritic rats also show increased oxidative stress as compared to control rats. This increased oxidative stress in the arthritic rats appears to be the outcome of both an activated pro-oxidant and a poor antioxidant defense system. Treatment with WSAq300 strongly ameliorates all these ROS parameters significantly to near normal. Additional, metalloproteinase MMP-8 levels were also measured and found to be increased in CIA rats, which after treatment with WSAq300 came down to near normal. Conclusion: From the above results, it can be concluded that the use of WSAq300 may be a valuable supplement which can improve human arthritis.

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Mobashar, Aisha, Arham Shabbir, Muhammad Shahzad und Glenda Gobe. „Preclinical Rodent Models of Arthritis and Acute Inflammation Indicate Immunomodulatory and Anti-Inflammatory Properties of Juglans regia Extracts“. Evidence-Based Complementary and Alternative Medicine 2022 (05.04.2022): 1–10. http://dx.doi.org/10.1155/2022/1695701.

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Juglans regia has been used to treat inflammatory and arthritic disorders in traditional medicine. The present study aimed to investigate the antiarthritic and anti-inflammatory potential of ethanolic leaves extract of J. regia. Arthritis was induced in rodents with Freund’s complete adjuvant. J. regia treatment was started on 8th day of arthritis induction and sustained for 20 days. Acute inflammatory models were developed using carrageenan, histamine, serotonin, and dextran. Qualitative and GC-MS analyses were also performed. Arthritis was determined using an arthritis scoring index and histopathological examination of ankle joints. RT-PCR was performed to determine the expression of pro-inflammatory markers (TNF-α, NF-κB, IL-6, IL-1β, and COX-2) and anti-inflammatory IL-4. PGE2 levels were evaluated using an ELISA. Blood and biochemical parameters were also determined. Paw edema was measured using a digital plethysmometer. Treatment with extracts inhibited arthritic development and attenuated paw edema along with all histopathological parameters. The expression levels of pro-inflammatory cytokines and COX-2 were downregulated, while IL-4 was upregulated. PGE2 levels were also reduced in extract-treated groups. Blood and biochemical parameters were nearly normalized in the treatment groups. Both extracts significantly inhibited carrageenan, histamine, serotonin, and dextran-induced paw edema. Qualitative phytochemical screening and GC-MS analysis confirmed that extracts possessed potential medicinal compounds. In conclusion, ethanol and n-hexane extracts of J. regia leaves have immunomodulatory and anti-inflammatory effects that ameliorate experimentally induced arthritis and edema. The inhibition of autacoids may also be one of the mechanisms inducing the immunomodulatory effect.

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Huang, W. N., und C. C. Lin. „AB0079 THEAFLAVIN ALLEVIATES COLLAGEN-INDUCED ARTHRITIS IN MICE BY DECREASING REACTIVE OXYGEN SPECIES AND PRO-INFLAMMATORY CYTOKINES“. Annals of the Rheumatic Diseases 82, Suppl 1 (30.05.2023): 1218.1–1218. http://dx.doi.org/10.1136/annrheumdis-2023-eular.5276.

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BackgroundAn autoimmune disease that causes inflammation and bone and cartilage deterioration is rheumatoid arthritis (RA). In the pathogenesis of RA, oxidative stress and pro-inflammatory cytokines are important factors. The main polyphenol in black tea, theaflavins (TFs), has been used medically to treat a variety of inflammatory illnesses by reducing inflammation and reactive oxygen species (ROS)ObjectivesThe medications available to treat RA have a variety of side effects. The current study was designed to assess the anti-arthritic properties of theaflavin in a mouse collagen-induced arthritis model.MethodsIn order to induce arthritis in DBA/1 mice, type II collagen was administered intradermally. From days 21 through days 42, different doses of theaflavin (50 and 100 mg/kg/day) were orally administered. To determine the effect of theaflavin on collagen-induced arthritis, histological analyses were conducted. In addition, the generation of reactive oxygen species (ROS), nitric oxide, and the activities of enzymatic antioxidants (superoxide dismutase, glutathione peroxidase, catalase, and glutathione reductase) in the joint homogenate of mice were examined. The levels of TNF-, IL-6, and IL-1β were also measured by ELISA to detect inflammation.ResultsOur results showed anti-oxidant and anti-inflammatory effects of theaflavin in arthritic mice. Histopathological studies corroborated the anti-arthritic properties of theaflavin. The compound was found to be effective in lowering ROS and nitric oxide levels while increasing enzymatic antioxidant levels. Theaflavin therapy also reduced TNF-, IL-6, and IL-1β levels.ConclusionIn mice with arthritis, theaflavin was successful in reducing inflammation and oxidative stress. These results suggest that theaflavin may be used in conjunction with other treatments to manage RA.Figure 1.TF ameliorated the severity of arthritis in CIA mouse models. (a) Representative photographs depicted the swollen and reddened rear paws of four animal groups 42 days following the initial vaccination. (b) Accumulated clinical arthritis scores in each leg ranged from 0 to 4 and were evaluated every three days using a visual scoring system. The changes in body weight of normal control or CIA mice treated with or without TF or vehicle were recorded every three days till day 42. (c) TNF-, IL-6, and IL-1 inflammatory cytokine protein levels in arthritic mouse hind paw tissues. On day 42, CIA in DBA/1 mice hind paw homogenates were taken from the normal control, vehicle-treated, or TF-treated (50 or 100 mg/kg) groups of mice. The cytokine profiles were measured using ELISA according to the techniques given. ** p < 0.01 and * p < 0.05 showed statistically significant differences in two-way ANOVA compared with the vehicle-treated CIA groupREFERENCES:NIL.Acknowledgements:NIL.Disclosure of InterestsNone Declared.

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Elmaidomy, Abeer H., Esraa M. Mohamed, Hanan F. Aly, Eman A. Younis, Shams Gamal Eldin Shams, Faisal H. Altemani, Mubarak A. Alzubaidi et al. „Anti-Inflammatory and Antioxidant Properties of Malapterurus electricus Skin Fish Methanolic Extract in Arthritic Rats: Therapeutic and Protective Effects“. Marine Drugs 20, Nr. 10 (14.10.2022): 639. http://dx.doi.org/10.3390/md20100639.

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The protective and therapeutic anti-inflammatory and antioxidant potency of Malapterurus electricus (F. Malapteruridae) skin fish methanolic extract (FE) (300 mg/kg.b.wt/day for 7 days, orally) was tested in monosodium urate(MSU)-induced arthritic Wistar albino male rats’ joints. Serum uric acid, TNF-α, IL-1β, NF-𝜅B, MDA, GSH, catalase, SOD, and glutathione reductase levels were all measured. According to the findings, FE significantly reduced uric acid levels and ankle swelling in both protective and therapeutic groups. Furthermore, it has anti-inflammatory effects by downregulating inflammatory cytokines, primarily through decreased oxidative stress and increased antioxidant status. All the aforementioned lesions were significantly improved in protected and treated rats with FE, according to histopathological findings. iNOS immunostaining revealed that protected and treated arthritic rats with FE had weak positive immune-reactive cells. Phytochemical analysis revealed that FE was high in fatty and amino acids. The most abundant compounds were vaccenic (24.52%), 9-octadecenoic (11.66%), palmitic (34.66%), stearic acids (14.63%), glycine (0.813 mg/100 mg), and alanine (1.645 mg/100 mg). Extensive molecular modelling and dynamics simulation experiments revealed that compound 4 has the potential to target and inhibit COX isoforms with a higher affinity for COX-2. As a result, we contend that FE could be a promising protective and therapeutic option for arthritis, aiding in the prevention and progression of this chronic inflammatory disease.

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Omere, E. A., A. U. Osaigbovo und A. T. Adekunle. „Soursop botany, chemical composition and medicinal prospects: a concise review“. Ghana Journal of Science 64, Nr. 1 (24.07.2023): 56–67. http://dx.doi.org/10.4314/gjs.v64i1.7.

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Soursop (Annona muricata L.) belongs to the family Annonaceae and is reported to have the largest fruit in the genus, Annona. It is best known as “sawasop” in Nigerian vernacular. It is a fruit tree that was in almost every home garden in time past. The need for space, urbanization, inadequate knowledge about the fruit tree potentials, economic relevance and/or preference, has led to its fast eroding out of the urban and semi-urban areas, with relatively fewer stands, compared to decades ago.Soursop has been reported to originate from the American tropics but has been successfully introduced and domesticated around the world. Several past and current researches have been aimed at revealing the medicinal potential and other properties of soursop. Hitherto, the reported ethnomedicinal properties of soursop include but not restricted to analgesic, antibacterial, anticancer, antifungal, antioxidant, antitumor, antiulcer, antiviral, anti-arthritic, anti-diabetic, anti-hypertensive, anti-inflammatory, anti-insomnia, anti-rheumatic, anti-stress, immune enhancing, as well as wound healing capacity. This review highlights a brief description of the botany, chemical composition and the burgeoning need for the utilization of soursop based on its inherent medicinal properties.

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Rohit Rawat, Amita Gupta und Nidhi Tripathi. „Cordyceps militaris as an alternative source of food, nutrition and medicine“. World Journal of Advanced Research and Reviews 22, Nr. 1 (30.04.2024): 1600–1620. http://dx.doi.org/10.30574/wjarr.2024.22.1.0767.

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In 2020 Covid 19 outbreak wreaked havoc on the entire world. Through constant hard days, the pandemic has taught us how important it is to have better immunity in our body to avoid diseases like covid 19. In the present-day scenario, there are a handful of factors like pollution, adulterated food items, chemical fertilizers, and pesticides, etc. which are slowly decreasing our immunity. In such a situation, Cordyceps militaris has emerged as a great solution. Cordyceps militaris is a medicinal mushroom, its products have been used as medicine in China for centuries, slowly, Cordyceps militaris is gaining fame in India and many other countries due to its exceptional immunomodulatory and other medicinal properties. Nutrition and immunity are two of the essential factors behind a healthy life. Cordyceps militaris imparts a positive effect on both. It is known for its nutritional and medicinal properties such as anti-aging, anti-inflammatory, antioxidant, anticancer, antiviral, effective in liver disorders, effective sexual disorder, cardiovascular diseases, antimalarial, anti-hyperlipidemia, anti-osteoporotic, anti-arthritic, anti-diabetic anti-fungal, immunomodulatory, etc. Due to the aforesaid exceptional properties, it increases health benefits manifold.

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Marius, Mbiantcha, Ateufack Gilbert, TsafackEric Gonzal, DjuichouNguemnang Stephanie Flore, AtsamoAlbert Donatien, NanaYousseu William, TadjouaTchoumbou Herve und MatahMarthe Mba Vanessa. „In vitro anti-inflammatory, anti-oxidant and in vivo anti-arthritic properties of stem bark extracts from Nauclea pobeguinii (Rubiaceae) in rats“. Asian Pacific Journal of Tropical Biomedicine 10, Nr. 2 (2020): 65. http://dx.doi.org/10.4103/2221-1691.275421.

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Lin, Shih-Chao, Chi-Chien Lin, Shiming Li, Wan-Yi Lin, Caitlin W. Lehman, Nicole R. Bracci und Sen-Wei Tsai. „Alleviation of Collagen-Induced Arthritis by Crotonoside through Modulation of Dendritic Cell Differentiation and Activation“. Plants 9, Nr. 11 (10.11.2020): 1535. http://dx.doi.org/10.3390/plants9111535.

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Crotonoside, a guanosine analog originally isolated from Croton tiglium, is reported to be a potent tyrosine kinase inhibitor with immunosuppressive effects on immune cells. Due to its potential immunotherapeutic effects, we aimed to evaluate the anti-arthritic activity of crotonoside and explore its immunomodulatory properties in alleviating the severity of arthritic symptoms. To this end, we implemented the treatment of crotonoside on collagen-induced arthritic (CIA) DBA/1 mice and investigated its underlying mechanisms towards pathogenic dendritic cells (DCs). Our results suggest that crotonoside treatment remarkably improved clinical arthritic symptoms in this CIA mouse model as indicated by decreased pro-inflammatory cytokine production in the serum and suppressed expression of co-stimulatory molecules, CD40, CD80, and MHC class II, on CD11c+ DCs from the CIA mouse spleens. Additionally, crotonoside treatment significantly reduced the infiltration of CD11c+ DCs into the synovial tissues. Our in vitro study further demonstrated that bone marrow-derived DCs (BMDCs) exhibited lower yield in numbers and expressed lower levels of CD40, CD80, and MHC-II when incubated with crotonoside. Furthermore, LPS-stimulated mature DCs exhibited limited capability to prime antigen-specific CD4+ and T-cell proliferation, cytokine secretions, and co-stimulatory molecule expressions when treated with crotonoside. Our pioneer study highlights the immunotherapeutic role of crotonoside in the alleviation of the CIA via modulation of pathogenic DCs, thus creating possible applications of crotonoside as an immunosuppressive agent that could be utilized and further explored in treating autoimmune disorders in the future.

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Patterson, Daryllynn C., Aleksandra P. Ignatowicz, Janaiya S. Samuels, Srujana Rayalam und Rangaiah Shashidharamurthy. „Lipocalin2, an innate immune protein, modulates iNOS and arginase-1 in macrophages to promote the anti-inflammatory function“. Journal of Immunology 198, Nr. 1_Supplement (01.05.2017): 206.16. http://dx.doi.org/10.4049/jimmunol.198.supp.206.16.

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Abstract Lipocalin 2 (Lcn2), an innate immune protein, is known to be dramatically up regulated in various inflammatory disorders including autoimmune arthritis, yet its biological role remains unclear. Recently our studies have shown an increase in the accumulation of macrophages in Lcn2 deficient mice compared to wild type (WT) mice in a serum transfer arthritic mouse model. Thus, indicating that the upregulation of Lcn2 might be necessary for the initiation and further resolution of inflammatory processes. In this study, we have investigated the anti-inflammatory function of Lcn2 using murine mouse macrophages. RAW 264.7 cells treated with INFγ and LPS both exhibited pro-inflammatory phenotype, M1, while cells treated with IL-4 displayed an anti-inflammatory phenotype, M2. To determine the anti-inflammatory effects of Lcn2 an IL-10 ELISA revealed that M2 macrophages in the presence of recombinant Lcn2 (rLcn2) significantly increased the expression of IL-10. In addition, arginase-1 expression was found to be significantly upregulated in M2 polarized macrophages in the presence of rLcn2 while inducible nitric oxide synthase (iNOS) expression was down-regulated in the M1 phenotype. However, RAW 264.7 cells treated with Lcn2 alone did not exert either pro- or anti-inflammatory effect. In conclusion, Lcn2 displays the ability to significantly increase the release of anti-inflammatory cytokine, IL-10, thus promoting the anti-inflammatory properties of M2 macrophages. Collectively, our data suggests a crucial role of Lcn2 in the resolution of arthritic inflammation via macrophage polarization, making it a promising target in designing better therapeutic strategies to control the ongoing inflammation during autoimmune arthritis.

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Senthil Kumar Raju, Sabarinath Chandrasekar, Hemalatha Dhandapani, Mathipriya Rajendran, Nithya Lingarajan, Sandhiya Devan, Praveen Sekar und Shridharshini Kumar. „Medically significant monotypic species Martynia annua L.: A review on ethnobotany, phytochemistry and pharmacology“. Open Access Research Journal of Biology and Pharmacy 7, Nr. 1 (30.01.2023): 010–20. http://dx.doi.org/10.53022/oarjbp.2023.7.1.0087.

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Martynia annua commonly known as Thael kodukkai belonging to the Martyniaceae family is an herbaceous plant with many medicinal properties. It is a weedy peculiar species native to tropical and subtropical regions of Mexico. The entire herb is found to exhibit potential pharmacological activities. The various parts of this plant have been reported to show many therapeutic indications like anticancer, antibacterial, anticonvulsant, anti-inflammatory, wound healing, analgesic, antipyretic activity, antioxidant, anti-diabetic, anti-nociceptive, immunomodulatory, hepatoprotective, anti-hemolytic, anti-thrombotic, anti-arthritic, anti-haemorrhoidal, anti-alopecia, anti-muscular, anti-helminthic, gastroprotective and anti-fertility activities. This review aims to provide the compilation of existing knowledge on the phytochemistry and pharmacological properties of M. annua from the reported studies. The phytochemical screening results of various extracts of stem, root, leaves and fruits of M. annua were discussed in this review. A greater number of phytoconstituents were reported to be present in leaves. This review suggests that this plant contains various phytoconstituents like anthraquinones, terpenoids, flavonoids, tannins and phenolic compounds that are responsible for various pharmacological activities. In the future, this plant provides an immense scope for pharmacological investigations.

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