Thematische Bibliographien / Anti-arthritic Properties

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Auswahl der wissenschaftlichen Literatur zum Thema „Anti-arthritic Properties“

Autor: Grafiati

Veröffentlicht am 18. Mai 2024

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Zeitschriftenartikel zum Thema "Anti-arthritic Properties"

Bala, Indu, und Pranav Kumar Prabhakar. „Unveiling Therapeutic Prospects: Evaluating the Anti-Arthritic Properties of Thymosin Alpha 1“. Journal of Multidisciplinary Research in Healthcare 10, Nr. 01 (13.10.2023): 13–18. http://dx.doi.org/10.15415/jmrh.2023.101002.

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Background: Thymosin alpha 1 is a peptide naturally occurring in the thymus that has long been recognized for modifying, enhancing, and restoring immune function. Purpose: The present study focuses on the effects of Thymosin alpha 1 on Body weight, Paw weight, paw volume and arthritic score of Collagen induced arthritis (CIA) rats. Methods: The wistar rats were randomly divided into 5 groups: nor-mal control, arthritic control, CIA+Ta-1 0.25mg/kg, CIA+Ta-1 0.5mg/kg and CIA+Ta-1 mg/kg. The collagen and lipopolysaccharide (LPS) were administered via the intraplantar route to the experimental rat subjects. Prior to the administration of collagen and LPS, the initial paw volume was measured, and the body weight was duly document-ed. The administration of the treatment occurred on the first, third, and fifth days. On the completion of the dosing period, specifically on the fifteenth day, the final body weight was duly recorded. The measurements of paw volume, paw weight, Body weight and arthritic score were duly recorded. Results: Following with the administration of Thymosin alpha-1 the arthritic rats shown significantly reduce the severity of arthritis by decreasing the symptoms of arthritis. Conclusions: Thymosin alpha-1 has shown a promising effect of the reduction in the pathophysiology of rheumatoid arthritis and hence it can be a better therapeutic candidate of future for the management of RA. The more detailed analysis of the mechanistic study may provide a better understanding.

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Khandelwal, V., Anita . und T. Sharma. „In vitro Anti-arthritic and Antioxidant properties of the aqueous and ethanolic extracts of Cordia myxa leaves“. Research Journal of Biotechnology 17, Nr. 5 (25.04.2022): 109–14. http://dx.doi.org/10.25303/1705rjbt109114.

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Many plants of Cordia genus are ethanomedically used to treat various diseased conditions like urine infection, leprosy, lung diseases and act as anti-inflammatory, anthelmintic, appetitie suppressant, cough suppressant, diuretic and antimalarial agents. Cordia myxa is one of that traditionally important plants. The aim of the present research is to investigate the chemical composition, antioxidant, anti-arthritic and anti-inflammatory effects of aqueous and ethanolic extracts of Cordia myxa leaves. Phytochemical investigation indicates the presence of alkaloids, phenols, flavanoids etc. responsible for tremendous pharmacological activities. Both the extracts were found to express significant free radical scavenging activity in dose dependent manner with highest 67.87% by aqueous extract. In vitro antiinflammatory and anti-arthritic were also determined where aqueous extract showed maximum inhibition in HRBC membrane lyses with 68.73% inhibition and 72.4% inhibition in protein denaturation which confers potential anti-arthritic activity.

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Alkahtani, Hamad M., Abdulrahman A. Almehizia, Mohamed A. Al-Omar, Ahmad J. Obaidullah, Amer A. Zen, Ashraf S. Hassan und Wael M. Aboulthana. „In Vitro Evaluation and Bioinformatics Analysis of Schiff Bases Bearing Pyrazole Scaffold as Bioactive Agents: Antioxidant, Anti-Diabetic, Anti-Alzheimer, and Anti-Arthritic“. Molecules 28, Nr. 20 (17.10.2023): 7125. http://dx.doi.org/10.3390/molecules28207125.

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In continuation of our research programs for the discovery, production, and development of the pharmacological activities of molecules for various disease treatments, Schiff bases and pyrazole scaffold have a broad spectrum of activities in biological applications. In this context, this manuscript aims to evaluate and study Schiff base–pyrazole molecules as a new class of antioxidant (total antioxidant capacity, iron-reducing power, scavenging activity against DPPH, and ABTS radicals), anti-diabetic (α-amylase% inhibition), anti-Alzheimer’s (acetylcholinesterase% inhibition), and anti-arthritic (protein denaturation% and proteinase enzyme% inhibitions) therapeutics. Therefore, the Schiff bases bearing pyrazole scaffold (22a, b and 23a, b) were designed and synthesized for evaluation of their antioxidant, anti-diabetic, anti-Alzheimer’s, and anti-arthritic properties. The results for compound 22b demonstrated significant antioxidant, anti-diabetic (α-amylase% inhibition), and anti-Alzheimer’s (ACE%) activities, while compound 23a demonstrated significant anti-arthritic activity. Prediction of in silico bioinformatics analysis (physicochemical properties, bioavailability radar, drug-likeness, and medicinal chemistry) of the target derivatives (22a, b and 23a, b) was performed. The molecular lipophilicity potential (MLP) of the derivatives 22a, b and 23a, b was measured to determine which parts of the surface are hydrophobic and which are hydrophilic. In addition, the molecular polar surface area (PSA) was measured to determine the polar surface area and the non-polar surface area of the derivatives 22a, b and 23a, b. This study could be useful to help pharmaceutical researchers discover a new series of potent agents that may act as an antioxidant, anti-diabetic, anti-Alzheimer, and anti-arthritic.

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Belal, Amany, Rehab Mahmoud, Mohamed Taha, Fatma Mohamed Halfaya, Ahmed Hassaballa, Esraa Salah Elbanna, Esraa Khaled et al. „Therapeutic Potential of Zeolites/Vitamin B12 Nanocomposite on Complete Freund’s Adjuvant-Induced Arthritis as a Bone Disorder: In Vivo Study and Bio-Molecular Investigations“. Pharmaceuticals 16, Nr. 2 (13.02.2023): 285. http://dx.doi.org/10.3390/ph16020285.

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Rheumatoid arthritis (RA) is a long-term autoimmune disease. As nanotechnology has advanced, a growing number of nanodrugs have been used in the treatment of RA due to their unique physical and chemical properties. The purpose of this study was to assess the therapeutic potential of a novel zeolite/vitamin B12 nanocomposite (Nano ZT/Vit B12) formulation in complete Freund’s adjuvant (CFA)-induced arthritis. The newly synthesized Nano ZT/Vit B12 was fully characterized using various techniques such as XRD, FT-IR, BET analysis, HERTEM, SEM, practical size, zeta potential, XRF, and EDX. The anti-arthritic, anti-inflammatory, and antioxidant activities as well as the immunomodulation effect of Nano ZT/Vit B12 on the CFA rat model of arthritis were examined. Histopathologic ankle joint injuries caused by CFA intrapedal injection included synovium hyperplasia, inflammatory cell infiltration, and extensive cartilage deterioration. The arthritic rats’ Nano ZT/Vit B12 supplementation significantly improved these effects. Furthermore, in arthritic rats, Nano ZT/Vit B12 significantly reduced serum levels of RF and CRP, as well as the levels of IL-1β, TNF-α, IL-17, and ADAMTS-5, while increasing IL-4 and TIMP-3 levels. Nano-ZT/Vit B12 significantly declined the LPO level and increased antioxidant activities, such as GSH content and GST activity, in the arthritic rats. In arthritic rats, Nano ZT/Vit B12 also reduced TGF-β mRNA gene expression and MMP-13 protein levels. Collectively, Nano ZT/Vit B12 seems to have anti-arthritic, anti-inflammatory, and antioxidant properties, making it a promising option for RA in the future.

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Pereira, Wanderson S., Girlaine P. da Silva, Mariana V. Vigliano, Nathalia R. F. Leal, Fabiana A. Pinto, Daniele C. Fernandes, Shirley V. M. Santos et al. „Anti-arthritic properties of crude extract fromChenopodium ambrosioidesL. leaves“. Journal of Pharmacy and Pharmacology 70, Nr. 8 (30.04.2018): 1078–91. http://dx.doi.org/10.1111/jphp.12926.

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A Meena, R Buvana, A Deepak, P Dinesh Kumar, K Divyapriya und D Duraiarasan. „Preparation and evaluation of anti-arthritic activity of Moringa oleifera leaves extract loaded silver nanoparticles“. International Journal of Scholarly Research and Reviews 2, Nr. 2 (30.06.2023): 096–106. http://dx.doi.org/10.56781/ijsrr.2023.2.2.0023.

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Silver Nanoparticles (Ag-NPs) are increasingly used in various fields including medical, food, healthcare consumer and industrial purposes due to their unique physical and chemical properties. The conventional physical and chemical methods of synthesis of Ag-NPs seem to be very expensive and hazardous. Interestingly, biologically prepared Ag-NPs show high yield, solubility and high stability. The biologically Ag-NPs was characterized by UV-visible spectroscopy and SEM with EDAX. The appearance of specific absorbance peak at 440 nm indicates the presence of Ag-NPs. The development of Ag-NPs as anti-arthritic molecules is one of the most interesting approaches for arthritic treatment as it can overcome poor delivery and the problem of drug resistance. The anti-arthritic activity of developed MO-AgNPs was determined by albumin denaturation assay. MO-AgNPs (Moringa Olifera leaves extract loaded silver nanoparticles) exhibit 25% higher anti-arthritic activity when compared with standard Aspirin drug.

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Belal, Amany, Rehab Mahmoud, Eman E. Mohamed, Ahmed Farghali, Fatma I. Abo El-Ela, Amr Gamal, Fatma Mohamed Halfaya et al. „A Novel Hydroxyapatite/Vitamin B12 Nanoformula for Treatment of Bone Damage: Preparation, Characterization, and Anti-Arthritic, Anti-Inflammatory, and Antioxidant Activities in Chemically Induced Arthritic Rats“. Pharmaceuticals 16, Nr. 4 (06.04.2023): 551. http://dx.doi.org/10.3390/ph16040551.

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The usage of nanomaterials for rheumatoid arthritis (RA) treatment can improve bioavailability and enable selective targeting. The current study prepares and evaluates the in vivo biological effects of a novel hydroxyapatite/vitamin B12 nanoformula in Complete Freund’s adjuvant-induced arthritis in rats. The synthesized nanoformula was characterized using XRD, FTIR, BET analysis, HERTEM, SEM, particle size, and zeta potential. We synthesized pure HAP NPs with 71.01% loading weight percentages of Vit B12 and 49 mg/g loading capacity. Loading of vitamin B12 on hydroxyapatite was modeled by Monte Carlo simulation. Anti-arthritic, anti-inflammatory, and antioxidant effects of the prepared nanoformula were assessed. Treated arthritic rats showed lower levels of RF and CRP, IL-1β, TNF-α, IL-17, and ADAMTS-5, but higher IL-4 and TIMP-3 levels. In addition, the prepared nanoformula increased GSH content and GST antioxidant activity while decreasing LPO levels. Furthermore, it reduced the expression of TGF-β mRNA. Histopathological examinations revealed an improvement in joint injuries through the reduction of inflammatory cell infiltration, cartilage deterioration, and bone damage caused by Complete Freund’s adjuvant. These findings indicate that the anti-arthritic, antioxidant, and anti-inflammatory properties of the prepared nanoformula could be useful for the development of new anti-arthritic treatments.

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Hajare, Pratiksha, Vaishali Rai, Sonali Nipate, Aishwarya Balap, Bhushan Pimple, Deshraj Chumbhale, Asmita Gaikwad und Harshal Tare. „Anti-arthritic potential of ethyl acetate fraction of <em>Pinus roxburghii</em> Sargent stem bark in Freund's complete adjuvant induced arthritis in Wistar rats“. Multidisciplinary Science Journal 5, Nr. 4 (07.06.2023): 2023046. http://dx.doi.org/10.31893/multiscience.2023046.

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Traditional and folk medicine regularly make use of the Pinus roxburghii Sargent (Pinaceae) plant. Unfortunately, there is a lack of data on this plant's potential anti-arthritic effects.Pinus roxburghii Sargent ethyl acetate stem bark has anti-arthritic properties in Wistar rats with arthritis produced by Freund's Complete adjuvant. As a positive control, diclofenac was administered. To define the anti-arthritic activity, the influence on pain perception parameter, haematological parameters, the effect on rheumatoid factor, CRP, and serum parameters were evaluated.In this study, the ethyl acetate fraction of Pinus roxburgii Sargent was found to significantly inhibit pain perception parameters at doses of 250 and 500 mg/kg. Serum levels of RF, NO, and CRP were significantly lower in the Pinus roxburghii Sargent group compared to the disease control group. In disease-free rats, Pinus roxburghii Sargent significantly raised RBC and lowered WBC, both of which point to a suppressive effect on inflammatory mediators. The number of inflammatory cells had decreased, as seen by histopathology. Several imaging parameters, including spur formation, joint spacing, bone erosion, etc., were significantly reduced in a radiological assessment.In this study, authors noted that Pinus roxburghii Sargent had a direct effect on slowing the progression of arthritis, reducing inflammation and synovitis, and protecting arthritic joints from cartilage and bone deterioration. Stem bark extract of Pinus roxburghii Sargent has been shown to have anti-arthritic action based on clinical, biochemical, and histological analysis. Yet more research is required to pin down the precise mechanism of action.

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Nouir, Sahar, Aicha Laouani, Ahmed Loghmari, Khaireddine Bouassida, Raoudha Slim, Rim Bouhajeb, Yosra Hasni, Khaled Saguem, Bouraoui Ouni und Amira Zaïri. „HPLC-DAD Analysis and Investigation of Biological Properties of the Leaves of Globularia alypum (L.), Infusion Extract“. Pharmaceuticals 16, Nr. 12 (14.12.2023): 1726. http://dx.doi.org/10.3390/ph16121726.

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Globularia alypum L. (GA) belonging to the Globulariaceae family is a Mediterranean plant which is widely used in traditional Tunisian medicine. The aim of this study was to investigate the phytochemical composition, antioxidant, anti-arthritic, antiproliferative, antibacterial and antibiofilm potential of aqueous GA leaf extracts (AGAL). Quantitative analyses of the different constituents of extracts were evaluated by high-performance liquid chromatography with photodiode-array detection (HPLC-DAD). Spectrophotometric methods and chemical tests were used for antioxidant and anti-arthritic activities. The antiproliferative study was evaluated using colorectal cancer SW620 cells, while the antibacterial assessment and analysis of the antibiofilm effects were determined by the microdilution method and the crystal violet assay, respectively. AGAL extracts presented several components, mainly Nepetin-7-Glucoside and trans-ferrulic acid. The results showed that they had an important antioxidant (IC50 = 0.34; 0.38 and 1.20 mg/mL) and anti-arthritic (IC50 = 2.94 mg/mL) properties, and these effects are displayed in a dose-dependent manner. In addition, this extract demonstrated significant antiproliferative (IC50 = 50 µg/mL), antibacterial (MIC = 6.25 mg/mL and MBC = 6.25 mg/mL), and antibiofilm (59.70% at 25 mg/mL) properties especially against S. aureus. The results achieved confirm the important role of this plant as a source of therapeutic activities.

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Ticona, Luis Apaza, Andreea Madalina Serban, Daly Apaza Ticona und Karla Slowing. „Anti-inflammatory and Anti-arthritic Activities of Aqueous Extract and Flavonoids from Tripodanthus acutifolius Leaves in Mice Paw Oedema“. Planta Medica International Open 8, Nr. 02 (27.05.2021): e43-e55. http://dx.doi.org/10.1055/a-1471-8947.

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Abstract Tripodanthus acutifolius, commonly known as Jamillo, is an herbal remedy used in traditional Andean medicine to treat joint problems, such as sprains, dislocations, and rheumatic pain. This study aimed to evaluate the in vitro and in vivo anti-inflammatory and anti-arthritic activity of the aqueous extract and isolated compounds of T. acutifolius. A bioguided phytochemical analysis based on NMR/MS was performed to identify the compounds of the aqueous extract from T. acutifolius. The anti-inflammatory and anti-arthritic activity were evaluated by measuring inflammatory parameters (TNF-α, C-reactive protein, and fibrinogen) in murine models. The chemical structure determination led to the identification of four flavonoids: (E)-2’,4’-dihydroxy-6’-methoxy-chalcone (1), 6,2’,4’-trimethoxyflavone (2), 5,3’,4’-trihydroxy-6,7,8-trimethoxyflavone (3), and 5,4’-dihydroxy-6,7,8-trimethoxyflavone (4). All compounds inhibited the production of TNF-α in the RAW 264.7 cell line, with IC50 values of 0.78, 1.43, 5.73, and 9.71 μM, respectively. In addition, all flavonoids decreased the levels of TNF-α, C-reactive protein, and fibrinogen at a concentration of 5 mg/kg in murine models. Our research shows that these compounds isolated from T. acutifolius have anti-inflammatory and anti-arthritic properties, providing scientific evidence for the traditional use of this plant species.

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Dissertationen zum Thema "Anti-arthritic Properties"

Paul, Subhashis. „Exploration of Anti-inflammatory and Anti-arthritic propertics of Aloe Vera (L.) Burm. f. from the Sub-Himalayan West Bengal, India“. Thesis, University of North Bengal, 2021. http://ir.nbu.ac.in/handle/123456789/4662.

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Cheng, Chi Yan. „Anti-arthritic properties of a herbal formula comprising Rosae Multiflorae Fructus and Lonicerae Japonicae Flos“. HKBU Institutional Repository, 2016. https://repository.hkbu.edu.hk/etd_oa/311.

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Rheumatoid arthritis (RA), the most common autoimmune disease, affects billions of people worldwide. Conventional therapeutics do not provide satisfactory efficacy and even cause severe adverse reactions. Researchers are seeking new approaches for RA management. Toll-like receptor 4 (TLR4) signalling plays a pivotal role in the pathogenesis of RA, and has been proposed as a potential therapeutic target for RA. Chinese medicines are believed to be alternative options for conventional RA therapeutics. A herbal formula RL, consisting of Rosae Multiflorae Fructus and Lonicerae Japonicae Flos, has traditionally been used in treating various inflammatory disorders including RA. In this study we assessed the anti-arthritic efficacy of RL in animals, and investigated the involvement of TLR4 signalling in RL's effects in vivo and in vitro. In vivo anti-arthritic efficacy of RL was evaluated using CIA (collagen-induced arthritis) rats, a model that is well established for studying human RA. Articular disease manifestations were investigated grossly, radiographically, and histologically. Isolated splenocytes were used to determine the effects of RL on immune responses. Molecular events in the TLR4 pathways upon RL treatment were examined in sera and joint tissues of CIA rats as well as in cultured lipopolysaccharide (LPS)-stimulated murine RAW264.7 and human THP-1 cells.

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Buchteile zum Thema "Anti-arthritic Properties"

Kumar, Dr Umesh, und Dr Yesh Pratap Singh Rana. „A COMPREHENSIVE REVIEW OF MICROSCOPICAL CHARACTERS OF POWDER OF STEM OF TINOSPORA CARDIFOLIA“. In MICROSCOPICAL EVALUATION OF MEDICINAL PLANTS. KAAV PUBLICATIONS, 2023. http://dx.doi.org/10.52458/9788196830014.2023.eb.ch-10.

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Tinospora cordifolia (T. cordifolia), commonly known as Guduchi, is extensively utilized in traditional and Ayurvedic medicine, including Ayurvedic 'Rasayanas,' to enhance the immune system and serve as a general tonic. It is valued for its anti-periodic, anti-spasmodic, anti-inflammatory, anti-arthritic, and anti-diabetic properties. Numerous studies have explored the health benefits of different parts of the Guduchi plant, with a predominant focus on T. cordifolia stem powder microscopy. In this investigation, stem powders microscopy of T. cordifolia were done through compound microscope. The morphology of the powders was examined using scanning electron microscopy.

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