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Auswahl der wissenschaftlichen Literatur zum Thema „Amphetamine Data“
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Zeitschriftenartikel zum Thema "Amphetamine Data"
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Martin-Iverson, Mathew T., und Bruce A. Lodge. „Effects of chronic treatment of rats with "designer" amphetamines on brain regional monoamines“. Canadian Journal of Physiology and Pharmacology 69, Nr. 12 (01.12.1991): 1825–32. http://dx.doi.org/10.1139/y91-270.
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(+)-Amphetamine and two structurally related analogues, 4-methoxyamphetamine and a recent "designer drug," 4-ethoxy-amphetamine, were given to rats via subcutaneous osmotic minipumps for 1–14 days. Regional brain levels of the drugs as well as monoamine neurotransmitters and some of their major acidic metabolites were determined. Amphetamine produced depletions of dopamine in the striatum after at least 3 days of treatment but not in the nucleus accumbens or olfactory tubercle, even after 14 days of treatment. In contrast, the two ring-substituted amphetamine analogues increased levels of the monoamines and decreased levels of their acid metabolites. These data indicate that the two ring-substituted amphetamine analogues, at least one of which is a potent hallucinogen, have potent monoamine oxidase inhibition properties that are sustained during chronic treatment. Furthermore, these two compounds do not share amphetamine's regionally selective neurotoxic effects on dopamine-releasing terminals, even though brain and striatal drug levels are the same or higher than those of amphetamine.Key words: (+)-amphetamine, 4-methoxyamphetamine, 4-ethoxyamphetamine, designer amphetamines, monoamines, rats, chronic treatment.
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Idayani, Sri, und Ni Luh Nova Dilisca Dwi Putri. „HUBUNGAN PERILAKU MEROKOK DENGAN PENGGUNAAN NAPZA JENIS AMPHETAMIN PADA MAHASISWA PERHOTELAN PERGURUAN TINGGI DI KOTA DENPASAR TAHUN 2019“. Bali Medika Jurnal 7, Nr. 1 (28.07.2020): 138–45. http://dx.doi.org/10.36376/bmj.v7i1.124.
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Salah satu faktor yang mempengaruh penyalahgunaan narkoba adalah kebiasaan merokok. Risiko terhadap penyalahgunaan narkoba cenderung meningkat pada seseorang yang memiliki kebiasaan merokok dan minum alkohol. NAPZA merupakan singkatan dari Narkotika, Psikotropika dan Bahan Adiktif berbahaya lainnya. Salah satu jenis NAPZA yaitu amphetamine. Amphetamine dapat berupa bubuk putih, kuning, maupun coklat, atau bubuk putih kristal kecil dan dapat juga berbentuk sediaan farmasi (tablet). Penelitian ini bertujuan untuk mengetahui hubungan antara perilaku merokok dengan penggunaan NAPZA jenis amphetamin dari urin mahasiswa perhotelan di Perguruan Tinggi Kota Denpasar Tahun 2019. Perilaku merokok dianalisa dari hasil wawancara menggunakan kuesioner dan kandungan amphetamine dari urin di uji dengan menggunakan metode rapid diagnostic test. Jumlah sampel yang urin yang dianalisa sebanyak 27 mahasiswa perhotelan Perguruan Tinggi di Kota Denpasar. Hasil penelitian menunjukkan, uji statistic Chi-Square diperoleh p-value tidak ada data statistik yang dihasilkan karena penggunanan NAPZA jenis amphetamine konstan. Hal tersebut berarti tidak ada hubungan antara perilaku merokok dengan penggunaan NAPZA jenis amphetamin pada urin mahasiswa perhotelan di Perguruan Tinggi Kota Denpasar Tahun 2019.
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Al-Imam, Ahmed. „Adverse Effects of Amphetamines on the Cardiovascular System: Review and Retrospective Analyses of Trends“. Global Journal of Health Science 9, Nr. 11 (18.09.2017): 102. http://dx.doi.org/10.5539/gjhs.v9n11p102.
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BACKGROUND: Amphetamine and amphetamine-type stimulants are powerful physical and psychostimulants; they are phenethylamine derivatives. The use of amphetamines can be either medicinal or illicit. Several amphetamines have been redesigned into illegal drugs of potent properties, also known as research chemicals and designer drugs. Hence, they are named novel (new) psychoactive substances (NPS).MATERIALS & METHODS: This study is a hybrid study of; data crunching and retrospective analysis of a trends database (1), and a systematic review of literature in relation to the amphetamines-induced adverse effects on the cardiovascular system (2). Google Trends database has been analysed in retrospect (2012-2017) to evaluate the attentiveness of surface web users towards amphetamine and a potent renowned amphetamine derivative known as captagon (fenethylline).RESULTS: Amphetamines appear to be highly popular worldwide, particularly in the developed world including North America and European countries, and to a less extent in the developing countries including the Middle East. However, the trends are oscillating with time with significant year-to-year changes although there was some steadiness in the temporal patterns (trends), for example in 2013-2014 (p-value=0.258). Variations in the trends were found to be correlated with global events including international terrorism. The adverse effects of amphetamines were found to be highly related to the cardiovascular system with a high incidence of intoxications and deaths among substance (ab)users.CONCLUSION: Several amphetamines are potent and used illicitly beyond their original therapeutic potential, as in the case of captagon, culminating in monumental public and economic threats. Legalising bodies should exercise tremendous and systematic efforts to counteract these threats. Database analyses can provide an accurate insight into this phenomenon that has been growing exponentially in the past decade.
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O'Reilly, Bridie, Paul Rysavy und Chris Moon. „The Illicit Drug Reporting System (IDRS) 1999: Northern Territory drug patterns and trends“. South Pacific Journal of Psychology 11, Nr. 2 (1999): 48–61. http://dx.doi.org/10.1017/s0257543400000602.
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AbstractThe national Illicit Drug Reporting System acts as an early warning system to detect and track amphetamine, heroin, cannabis, and cocaine use patterns and emerging trends. In the Northern Territory, structured interviews of 28 key informants and analysis of other drug indicator data, demonstrated that there was were diverse groups of amphetamine, opiate, and cannabis users in Darwin. There were reports of increasing use by Aborigines and youth. Amphetamines and morphine were usually injected and there had been a 338% increase in needle and syringe distribution in the 4 years to 1998/99. MS Contin 100mg was the usual opiate used, and the consumption of this Schedule 8 morphine narcotic had increased 1,100% from 1996 to 1998. Opiate overdoses were rare. The purity of amphetamines was low, but cannabis potency was high. All three drugs were considered to be easy to obtain. The policy and research implications of the results are discussed.
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Oliveira, Lúcio Garcia de, Letícia Maria de Araújo de Souza, Lúcia Pereira Barroso, Marcela Júlio César Gouvêa, Carlos Vinícius Dias de Almeida, Daniel Romero Muñoz und Vilma Leyton. „Occupational conditions and the risk of the use of amphetamines by truck drivers“. Revista de Saúde Pública 49 (2015): 1–9. http://dx.doi.org/10.1590/s0034-8910.2015049005944.
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OBJECTIVE To test whether the occupational conditions of professional truck drivers are associated with amphetamine use after demographic characteristics and ones regarding mental health and drug use are controlled for.METHODS Cross-sectional study, with a non-probabilistic sample of 684 male truck drivers, which was collected in three highways in Sao Paulo between years 2012 and 2013. Demographic and occupational information was collected, as well as data on drug use and mental health (sleep quality, emotional stress, and psychiatric disorders). A logistic regression model was developed to identify factors associated with amphetamine use. Odds ratio (OR; 95%CI) was defined as the measure for association. The significance level was established as p < 0.05.RESULTS The studied sample was found to have an average age of 36.7 (SD = 7.8) years, as well as low education (8.6 [SD = 2.3] years); 29.0% of drivers reported having used amphetamines within the twelve months prior to their interviews. After demographic and occupational variables had been controlled for, the factors which indicated amphetamine use among truck drivers were the following: being younger than 38 years (OR = 3.69), having spent less than nine years at school (OR = 1.76), being autonomous (OR = 1.65), working night shifts or irregular schedules (OR = 2.05), working over 12 hours daily (OR = 2.14), and drinking alcohol (OR = 1.74).CONCLUSIONS Occupational aspects are closely related to amphetamine use among truck drivers, which reinforces the importance of closely following the application of law (Resting Act (“Lei do Descanso”); Law 12,619/2012) which regulates the workload and hours of those professionals. Our results show the need for increased strictness on the trade and prescription of amphetamines in Brazil.
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Fonseca, Juliana Gusmão, Gustavo Magalhães Viana, Joyce Elen Murça de Souza und Luiza Augusta Rosa Rossi-Barbosa. „FATORES ASSOCIADOS AO USO DE ANFETAMINAS ENTRE CAMINHONEIROS“. Revista Interdisciplinar de Estudos em Saúde 8, Nr. 1 (27.06.2019): 116–25. http://dx.doi.org/10.33362/ries.v8i1.1474.
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As anfetaminas conhecidas como "rebites" são normalmente utilizadas por caminhoneiros. Este estudo teve como objetivo verificar a prevalência e fatores associados à utilização autorrelatada de anfetaminas entre caminhoneiros que trafegam na rodovia BR 251, no trecho de Montes Claros, MG, com parada em um posto de combustível. Trata-se de um estudo transversal, quantitativo com seleção dos indivíduos por amostragem de conveniência. Foi utilizado um questionário com dados sociodemográficos, econômicos, ocupacionais e relacionados às anfetaminas. Realizou-se a análise bivariada, cuja variável dependente foi o uso de anfetaminas e aquelas que apresentaram associação ao nível de 20% (p≤0,20) foram selecionadas para a análise múltipla utilizando a Regressão de Poisson. Permaneceram no modelo as variáveis com desfecho ao nível de 5% (p≤ 0,05). Dentre os 306 pesquisados, 22,2% eram usuários de anfetaminas, sendo o princípio ativo mais utilizado o Femproporex (Desobesi®). A média de idade foi de 41 anos, variando de 22 a 77 anos. A maioria trabalha mais de 10 horas diárias. O uso de anfetaminas esteve associado aos profissionais mais jovens e com maior carga horária de trabalho. Faz-se necessário um controle maior sobre a venda desses medicamentos por parte dos órgãos competentes.Palavras-chave: Prevalência. Anfetaminas. Drogas Ilícitas. FACTORS ASSOCIATED WITH THE AMPHETAMINES USE AMONG TRUCK DRIVERSABSTRACT: Amphetamines known as "rivets" are commonly used by truck drivers. This study aimed to verify the prevalence and factors associated with the self-reported use of amphetamines among truck drivers who travel on the BR 251 highway, in the Montes Claros stretch, MG, stopping at a fuel station. It is a cross-sectional, quantitative study with selection of individuals by convenience sampling. A questionnaire with socio-demographic, economic, occupational and amphetamine-related data was used. The bivariate analysis was performed, whose dependent variable was the use of amphetamines, and those that showed association at the level of 20% (p≤0.20) were selected to multiple variety analysis using Poisson Regression. Remain in analysis only variables whose end point was 5% (p≤0.05). Among 306 participants, 22.2% had used amphetamine, Femproporex (Desobesi®)was the most common active principle used. Mean age was 41 years, range 22 to 77 years old. Most interviewed works more than 10 hours a day. Younger drivers and more daily hours of work were associated with amphetamine use. Finally, to decrease amphetamine use and abuse, it is essential a closer sale control on this drugs by the government.Keywords: Prevalence. Amphetamines. Illicit Drugs.
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Reissig, James E., und Amy M. Rybarczyk. „Pharmacologic Treatment of Opioid-Induced Sedation in Chronic Pain“. Annals of Pharmacotherapy 39, Nr. 4 (April 2005): 727–31. http://dx.doi.org/10.1345/aph.1e309.
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OBJECTIVE: To review the literature for pharmacologic management of opioid-induced sedation (OIS) in patients with chronic pain. DATA SOURCES: A search of MEDLINE (1966–October 2004) for English-language literature and selected bibliographies was completed. Search terms included pain, opioid, sedation, psychostimulants, amphetamines, modafinil, and donepezil. DATA SYNTHESIS: Amphetamines and amphetamine-like agents, caffeine, donepezil, and modafinil have been evaluated for OIS. Available literature is limited by numbers of subjects, duration, and trial design; however, there is limited support for the use of methylphenidate, donepezil, and modafinil. CONCLUSIONS: Pharmacologic treatment of OIS should be utilized selectively, given the available literature. Methylphenidate, donepezil, and modafinil may be considered in appropriate patients.
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Jonson, C. S. L. „Amphetamine profiling — improvements of data processing“. Forensic Science International 69, Nr. 1 (November 1994): 45–54. http://dx.doi.org/10.1016/0379-0738(94)90048-5.
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Hasenhuetl, Peter S., Shreyas Bhat, Felix P. Mayer, Harald H. Sitte, Michael Freissmuth und Walter Sandtner. „A kinetic account for amphetamine-induced monoamine release“. Journal of General Physiology 150, Nr. 3 (09.02.2018): 431–51. http://dx.doi.org/10.1085/jgp.201711915.
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The plasmalemmal monoamine transporters for dopamine, norepinephrine, and serotonin (SERT) are targets for amphetamines. In vivo, amphetamines elicit most, if not all, of their actions by triggering monoamine efflux. This is thought to be accomplished by an amphetamine-induced switch from the forward-transport to the substrate-exchange mode. The mechanism underlying this switch has remained elusive; available kinetic models posit that substrates and cosubstrate Na+ ions bind either in a random or in a sequential order. Neither can account for all reported experimental observations. We used electrophysiological recordings to interrogate crucial conformational transitions associated with the binding of five different substrates (serotonin, para-chloroamphetamine, and the high-affinity naphthyl-propan-amines PAL-287, PAL-1045, and PAL-1046) to human SERT expressed in HEK293 cells; specifically, we determined the relaxation kinetics of SERT from a substrate-loaded to a substrate-free state at various intracellular and extracellular Na+ concentrations. These rates and their dependence on intracellular and extracellular Na+ concentrations differed considerably between substrates. We also examined the effect of K+ on substrate affinity and found that K+ enhanced substrate dissociation. A kinetic model was developed, which allowed for random, but cooperative, binding of substrate and Na+ (or K+). The synthetic data generated by this model recapitulated the experimental observations. More importantly, the cooperative binding model accounted for the releasing action of amphetamines without any digression from alternating access. To the best of our knowledge, this model is the first to provide a mechanistic framework for amphetamine-induced monoamine release and to account for the findings that some substrates are less efficacious than others in promoting the substrate-exchange mode.
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Tetlow, V. A., und J. Merrill. „Rapid Determination of Amphetamine Stereoisomer Ratios in Urine by Gas Chromatography—Mass Spectroscopy“. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 33, Nr. 1 (Januar 1996): 50–54. http://dx.doi.org/10.1177/000456329603300107.
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We describe a method for the determination of amphetamine optical isomer ratios. A simple basic extraction of amphetamine from urine is followed by on-column derivatization with (S)–(−)-N-(trifluoroacetyl)-L-prolyl chloride and analysis by gas chromatography—mass spectroscopy. This approach has been shown to be satisfactory for the separation of d- and l-amphetamine isomers and precision data shows the method to be reproducible. Patient data is presented to demonstrate the ability to differentiate between patients taking d-amphetamine and those using illicit (racemic) amphetamine by their l/d amphetamine ratio.
Dissertationen zum Thema "Amphetamine Data"
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Pawar, Yash. „Bayes Factors for the Proposition of a Common Source of Amphetamine Seizures“. Thesis, Linköpings universitet, Statistik och maskininlärning, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-176416.
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This thesis sets out to address the challenges with the comparison of Amphetamine material in determining whether they originate from the same source or different sources using pairwise ratios of peak areas within each chromatogram of material and then modeling the difference between the ratios for each comparison as a basis for evaluation. The evaluation of an existing method that uses these ratios to determine the sum of significant differences between each comparison of material that is provided is done. The outcome of this evaluation suggests that there the distributions for comparison of samples originating from the same source and the comparison of samples originating from different sources have an overlap leading to uncertainties in conclusions. In this work, the differences between the ratios of peak areas have been modeled using a feature-based approach. Because the feature space is quite large, Discriminant Analysis methods such as Linear Discriminant Analysis (LDA) and Partial least squares Discriminant Analysis (PLS-DA) have been implemented to perform classification by dimensionality reduction. Another popular method that works on the principle of nearest centroid classifier called as Nearest shrunken centroid is also applied that performs classification on shrunken centroids of the features. The results and analysis of all the methods have been performed to obtain the classification results for classes +1 (samples originate from the same source) and ́1 (samples originate from different sources). Likelihood ratios of each class for each of these methods have also been evaluated using the Empirical Cross-Entropy (ECE) method to determine the robustness of the classifiers. All three models seem to have performed fairly well in terms of classification with LDA being the most robust and reliable with its predictions.
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(9708611), Zackery Ray Roberson. „Advances in Gas Chromatography and Vacuum UV Spectroscopy: Applications to Fire Debris Analysis & Drugs of Abuse“. Thesis, 2021.
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In forensic chemistry, a quicker and more accurate analysis of a sample is always being pursued. Speedy analyses allow the analyst to provide quick turn-around times and potentially decrease back-logs that are known to be a problem in the field. Accurate analyses are paramount with the futures and lives of the accused potentially on the line. One of the most common methods of analysis in forensic chemistry laboratories is gas chromatography, chosen for the relative speed and efficiency afforded by this method. Two major routes were attempted to further improve on gas chromatography applications in forensic chemistry.The first route was to decrease separation times for analysis of ignitable liquid residues by using micro-bore wall coated open-tubular columns. Micro-bore columns are much shorter and have higher separation efficiencies than the standard columns used in forensic chemistry, allowing for faster analysis times while maintaining the expected peak separation. Typical separation times for fire debris samples are between thirty minutes and one hour, the micro-bore columns were able to achieve equivalent performance in three minutes. The reduction in analysis time was demonstrated by analysis of ignitable liquid residues from simulated fire debris exemplars.
The second route looked at a relatively new detector for gas chromatography known as a vacuum ultraviolet (VUV) spectrophotometer. The VUV detector uses traditional UV and far-ultraviolet light to probe the pi and sigma bonds of the gas phase analytes as well as Rydberg traditions to produce spectra that are nearly unique to a compound. Thus far, the only spectra that were not discernable were from enantiomers, otherwise even diastereomers have been differentiated. The specificity attained with the VUV detector has achieved differentiation of compounds that mass spectrometry, the most common detection method for chromatography in forensic chemistry labs, has difficulty distinguishing. This specificity has been demonstrated herein by analyzing various classes of drugs of abuse and applicability to “real world” samples has been demonstrated by analysis of de-identified seized samples.
Bücher zum Thema "Amphetamine Data"
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Patterns and trends of amphetamine-type stimulants (ATS) and other drugs of abuse in East Asia and the Pacific 2006: A report from project: TDRASF97, Improving ATS data and information systems. Bangkok: United Nations Office on Drugs and Crime, Regional Center for East Asia and the Pacific, 2007.
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Mahon, Katie, Manuela Russo und M. Mercedes Perez-Rodriguez. Cognitive Enhancement in Bipolar Disorder. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190214401.003.0011.
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Neurocognitive deficits are acknowledged as integral features of bipolar disorder (BD) and are known to contribute to the compromised level of functioning in individuals with BD. This chapter provides an overview of the current state of cognitive enhancement in BD. Few pharmacological agents have been investigated with regard to their potential for pro-cognitive effects in BD. Dopaminergic agents (pramipexole) and stimulants (modafinil, armodafinil, and amphetamine) as adjunctive treatment in BD appear to be promising cognitive enhancers, and there are few ongoing randomized clinical trials targeting both cognitive dysfunctions and clinical symptomatology in BD. Glutamatergic agents (d-cycloserine) may hold promise as potential cognitive enhancing agents in BD; however, as for dopaminergic agents and stimulants, no conclusive data exist. Larger samples and longer follow-up are needed to obtain a deep understanding of the efficacy and safety of these compounds and their role in the neurobiological mechanisms underpinning cognition in BD.
Buchteile zum Thema "Amphetamine Data"
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Ghaemi, S. Nassir. „Carcinogenicity of Psychotropic Drugs“. In Clinical Psychopharmacology, herausgegeben von S. Nassir Ghaemi, 307–10. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199995486.003.0025.
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The use of psychotropic medications has dramatically increased over the past two decades, especially with serotonin reuptake inhibitors and amphetamines. The majority of U.S. prescriptions for psychotropic drugs happen at the primary care level, usually for anxiety and depressive symptoms and their physical correlates. Given the extensive use of these agents, carcinogenic risk should be carefully weighed when prescribing long-term drug therapies. Some psychotropic drugs have some evidence of carcinogenicity based on animal (preclinical) studies. Other agents do not have such evidence. Whether such risk extends into long-term human use is unclear. The animal data are summarized here and available human data also are investigated.
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Ghaemi, S. Nassir. „Children“. In Clinical Psychopharmacology, herausgegeben von S. Nassir Ghaemi, 331–41. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199995486.003.0028.
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In this chapter, other aspects of psychopharmacological treatment of children are considered, specifically for diagnoses or symptoms of depression, manic states, anxiety, and behavioral problems, as well as autism and OCD. The occurrence of psychiatric symptoms in children does not reflect static disease entities, usually, but rather either diseases in process, which become evident in their final state in adulthood, or other social and cultural factors, such as abuse, trauma, and neglect. Attention deficit disorder (ADD) is not a disease in itself, usually, but rather a mistaken diagnosis when distractibility or impulsivity is caused by mood illnesses or anxiety states. Long-term randomized data with amphetamines indicate no greater functional benefit than with psychosocial interventions for ADD. Notable harms exist, including stunted height and possible neurotoxicity.
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Zhang, Xuefeng, und Thomas R. Kosten. „Evidence-Based Pharmacotherapy for Cocaine, Amphetamine, and Methamphetamine Use Disorders“. In Substance Use Disorders, 283–306. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780190920197.003.0016.
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Cocaine use disorder is one of the important stimulants use disorders worldwide, and amphetamine/methamphetamine misuse is a growing epidemic. There are no pharmacotherapy treatments approved by the US Food and Drug Administration (FDA) available for these illnesses. Numerous treatments based on a variety of strategies from psychotherapy, pharmacotherapy, to neuromodulation have been tested to date. Clinical efficacy of the trialed treatments, including both negative and positive outcomes. are reviewed and discussed in this chapter. In summary, many agents and interventions showed promising therapeutic potential in preclinical and early phase clinical trials but eventually failed in later larger trials. Thus, behavioral interventions and supportive therapy focusing on detoxification, initial recovery, and relapse prevention remain the major therapeutic approach due to lack of targeted treatment. New strategies and models are urgently needed to develop effective treatments for these detrimental disorders.
Konferenzberichte zum Thema "Amphetamine Data"
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Gosav, S., und M. Praisler. „The influence of input data preprocessing and of learning error on the performances of ANN systems identifying amphetamines“. In 2010 IEEE International Conference on Automation, Quality and Testing, Robotics (AQTR 2010). IEEE, 2010. http://dx.doi.org/10.1109/aqtr.2010.5520790.
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