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Thematische Bibliographien / Aminoglycosides uptake / Zeitschriftenartikel

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Zeitschriftenartikel zum Thema „Aminoglycosides uptake“

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Veröffentlicht am 25. Mai 2024

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1

Ford, D. M., R. H. Dahl, C. A. Lamp, and B. A. Molitoris. "Apically and basolaterally internalized aminoglycosides colocalize in LLC-PK1 lysosomes and alter cell function." American Journal of Physiology-Cell Physiology 266, no. 1 (1994): C52—C57. http://dx.doi.org/10.1152/ajpcell.1994.266.1.c52.

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Aminoglycosides bind to apical and basolateral (BL) membranes of renal epithelial cells. However, little is known regarding differential uptake and intracellular processing after internalization across these distinct surface membrane domains. To examine these processes independently, LLC-PK1 cells were grown on porous filters, which allow selective access to both domains. Apical and BL membrane uptakes of gentamicin (0.5 mM), quantified using [3H]gentamicin, were linear from 2 to 24 h (r = 0.99). The 4-h apical gentamicin uptake was 667 +/- 59 pmol/mg protein, the BL 748 +/- 26 pmol/mg protein

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Rodriguez, Mônica B., and Sérgio O. P. Costa. "Spontaneous kanamycin-resistant Escherichia coli mutant with altered periplasmic oligopeptide permease protein (OppA) and impermeability to aminoglycosides." Revista de Microbiologia 30, no. 2 (1999): 153–56. http://dx.doi.org/10.1590/s0001-37141999000200013.

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A spontaneous kanamycin-resistant Escherichia coli mutant, showing cross resistance to five other aminoglycosides and absence of the OppA protein was isolated. [3H]-dihydrostreptomycin uptake is reduced in this mutant, implying that the oligopeptide transport system is involved in accumulation of aminoglycosides, although apparently not related with aminoglycoside permeability alteration due to bacterial adaptation to osmotic changes.

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McCollister, Bruce D., Matthew Hoffman, Maroof Husain, and Andrés Vázquez-Torres. "Nitric Oxide Protects Bacteria from Aminoglycosides by Blocking the Energy-Dependent Phases of Drug Uptake." Antimicrobial Agents and Chemotherapy 55, no. 5 (2011): 2189–96. http://dx.doi.org/10.1128/aac.01203-10.

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ABSTRACTOur investigations have identified a mechanism by which exogenous production of nitric oxide (NO) induces resistance of Gram-positive and -negative bacteria to aminoglycosides. An NO donor was found to protectSalmonellaspp. against structurally diverse classes of aminoglycosides of the 4,6-disubstituted 2-deoxystreptamine group. Likewise, NO generated enzymatically by inducible NO synthase of gamma interferon-primed macrophages protected intracellularSalmonellaagainst the cytotoxicity of gentamicin. NO levels that elicited protection against aminoglycosides repressedSalmonellarespirato

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Ezraty, Benjamin, Alexandra Vergnes, Manuel Banzhaf, et al. "Fe-S Cluster Biosynthesis Controls Uptake of Aminoglycosides in a ROS-Less Death Pathway." Science 340, no. 6140 (2013): 1583–87. http://dx.doi.org/10.1126/science.1238328.

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All bactericidal antibiotics were recently proposed to kill by inducing reactive oxygen species (ROS) production, causing destabilization of iron-sulfur (Fe-S) clusters and generating Fenton chemistry. We find that the ROS response is dispensable upon treatment with bactericidal antibiotics. Furthermore, we demonstrate that Fe-S clusters are required for killing only by aminoglycosides. In contrast to cells, using the major Fe-S cluster biosynthesis machinery, ISC, cells using the alternative machinery, SUF, cannot efficiently mature respiratory complexes I and II, resulting in impendence of t

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Mao, Weimin, Mark S. Warren, Angela Lee, Anita Mistry, and Olga Lomovskaya. "MexXY-OprM Efflux Pump Is Required for Antagonism of Aminoglycosides by Divalent Cations inPseudomonas aeruginosa." Antimicrobial Agents and Chemotherapy 45, no. 7 (2001): 2001–7. http://dx.doi.org/10.1128/aac.45.7.2001-2007.2001.

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ABSTRACT Antagonism of aminoglycosides by divalent cations is well documented for Pseudomonas aeruginosa and is regarded as one of the problems in aminoglycoside therapy. It is generally considered that divalent cations interfere with uptake of aminoglycosides at both the outer and inner membranes. It has been demonstrated recently that aminoglycosides can be removed from cells ofP. aeruginosa by the three-component multidrug resistance efflux pump MexXY-OprM. We sought to investigate the interplay between efflux and uptake in resistance to aminoglycosides inP. aeruginosa. To do so, we studied

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Kang, Hyung Sub, Dirk Kerstan, Long-jun Dai, Gordon Ritchie, and Gary A. Quamme. "Aminoglycosides inhibit hormone-stimulated Mg2+ uptake in mouse distal convoluted tubule cells." Canadian Journal of Physiology and Pharmacology 78, no. 8 (2000): 595–602. http://dx.doi.org/10.1139/y00-038.

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The clinical use of aminoglycosides often leads to renal magnesium wasting and hypomagnesemia. Of the nephron segments, both the thick ascending limb of Henle's loop and the distal tubule play significant roles in renal magnesium conservation but the distal convoluted tubule exerts the final control of urinary excretion. An immortalized mouse distal convoluted tubule (MDCT) cell line has been extensively used to study the cellular mechanisms of magnesium transport in this nephron segment. Peptide hormones, such as parathyroid hormone (PTH), glucagon, calcitonin, and arginine vasopressin (AVP)

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Jassem, Agatha N., James E. A. Zlosnik, Deborah A. Henry, Robert E. W. Hancock, Robert K. Ernst, and David P. Speert. "In VitroSusceptibility of Burkholderia vietnamiensis to Aminoglycosides." Antimicrobial Agents and Chemotherapy 55, no. 5 (2011): 2256–64. http://dx.doi.org/10.1128/aac.01434-10.

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ABSTRACTBurkholderia cepaciacomplex (BCC) bacteria are opportunistic pathogens that can cause severe disease in cystic fibrosis (CF) patients and other immunocompromised individuals and are typically multidrug resistant. Here we observed that unlike other BCC species, most environmental and clinicalBurkholderia vietnamiensisisolates were intrinsically susceptible to aminoglycosides but not to cationic antimicrobial peptides or polymyxin B. Furthermore, strains acquired aminoglycoside resistance during chronic CF infection, a phenomenon that could be induced under tobramycin or azithromycin pre

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8

Hadidi, Kaivin, Ezequiel Wexselblatt, Jeffrey D. Esko, and Yitzhak Tor. "Cellular uptake of modified aminoglycosides." Journal of Antibiotics 71, no. 1 (2017): 142–45. http://dx.doi.org/10.1038/ja.2017.131.

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9

Jiang, Meiyan, Hongzhe Li, Anastasiya Johnson, et al. "Inflammation up-regulates cochlear expression of TRPV1 to potentiate drug-induced hearing loss." Science Advances 5, no. 7 (2019): eaaw1836. http://dx.doi.org/10.1126/sciadv.aaw1836.

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Aminoglycoside antibiotics are essential for treating life-threatening bacterial infections, despite the risk of lifelong hearing loss. Infections induce inflammation and up-regulate expression of candidate aminoglycoside-permeant cation channels, including transient receptor potential vanilloid-1 (TRPV1). Heterologous expression of TRPV1 facilitated cellular uptake of (fluorescently tagged) gentamicin that was enhanced by agonists, and diminished by antagonists, of TRPV1. Cochlear TRPV1 was immunolocalized near the apical membranes of sensory hair cells, adjacent supporting cells, and margina

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10

Schlessinger, D. "Failure of aminoglycoside antibiotics to kill anaerobic, low-pH, and resistant cultures." Clinical Microbiology Reviews 1, no. 1 (1988): 54–59. http://dx.doi.org/10.1128/cmr.1.1.54.

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The critical inhibition of ribosome function by aminoglycosides has long been established. But the binding of drug to ribosomes is reversible: why then are aminoglycosides bactericidal? Several groups have shown that irreversible action (lethality) results from irreversible uptake into susceptible cells; conversely, resistance in cases such as anaerobiosis is associated with the failure of uptake. Oddly, the pattern of results excludes all traditional transport mechanisms; most unusual is the apparent dependence of uptake on the interaction of drug with ribosomes. A traditional view that ribos

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El'Garch, Farid, Katy Jeannot, Didier Hocquet, Catherine Llanes-Barakat, and Patrick Plésiat. "Cumulative Effects of Several Nonenzymatic Mechanisms on the Resistance of Pseudomonas aeruginosa to Aminoglycosides." Antimicrobial Agents and Chemotherapy 51, no. 3 (2006): 1016–21. http://dx.doi.org/10.1128/aac.00704-06.

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ABSTRACT Screening of a Tn5-Hg insertional library (12,000 clones) constructed in wild-type Pseudomonas aeruginosa strain PAO1 identified four genes (namely, galU, nuoG, mexZ, and rplY) whose disruption individually led to increased resistance to aminoglycosides (means of twofold). Inactivation of these genes was associated with (i) impaired outer membrane uptake, (ii) reduced active transport, (iii) increased MexXY-OprM-mediated active efflux, and (iv) alteration of target of aminoglycosides, respectively. In addition, suppression of the gene rplY, which codes for ribosomal protein L25, was f

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12

Zemke, Anna C., Mark T. Gladwin, and Jennifer M. Bomberger. "Sodium Nitrite Blocks the Activity of Aminoglycosides against Pseudomonas aeruginosa Biofilms." Antimicrobial Agents and Chemotherapy 59, no. 6 (2015): 3329–34. http://dx.doi.org/10.1128/aac.00546-15.

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ABSTRACTSodium nitrite has broad antimicrobial activity at pH 6.5, including the ability to prevent biofilm growth byPseudomonas aeruginosaon the surfaces of airway epithelial cells. Because of its antimicrobial activity, nitrite is being investigated as an inhaled agent for chronicP. aeruginosaairway infections in cystic fibrosis patients. However, the interaction between nitrite and commonly used aminoglycosides is unknown. This paper investigates the interaction between nitrite and tobramycin in liquid culture, abiotic biofilms, and a biotic biofilm model simulating the conditions in the cy

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Krahn, Thomas, Christie Gilmour, Justin Tilak, et al. "Determinants of Intrinsic Aminoglycoside Resistance in Pseudomonas aeruginosa." Antimicrobial Agents and Chemotherapy 56, no. 11 (2012): 5591–602. http://dx.doi.org/10.1128/aac.01446-12.

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ABSTRACTScreening of a transposon insertion mutant library ofPseudomonas aeruginosafor increased susceptibility to paromomycin identified a number of genes whose disruption enhanced susceptibility of this organism to multiple aminoglycosides, including tobramycin, amikacin, and gentamicin. These included genes associated with lipid biosynthesis or metabolism (lptA,faoA), phosphate uptake (pstB), and two-component regulators (amgRS, PA2797-PA2798) and a gene of unknown function (PA0392). Deletion mutants lacking these showed enhanced panaminoglycoside susceptibility that was reversed by the clo

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Luedtke, Nathan W., Peter Carmichael, and Yitzhak Tor. "Cellular Uptake of Aminoglycosides, Guanidinoglycosides, and Poly-arginine." Journal of the American Chemical Society 125, no. 41 (2003): 12374–75. http://dx.doi.org/10.1021/ja0360135.

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Chan, Gary L. C. "Alternative Dosing Strategy for Aminoglycosides: Impact on Efficacy, Nephrotoxicity, and Ototoxicity." DICP 23, no. 10 (1989): 788–94. http://dx.doi.org/10.1177/106002808902301010.

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Accumulating evidence suggests that the therapeutic margin of aminoglycoside therapy may be improved by manipulation of dosing strategy. Recent understanding of concentration-dependent bactericidal activity and postantibiotic effect argues that the aminoglycosides may be administered in larger doses and at longer dosing intervals than currently recommended without compromising efficacy. Preliminary clinical experience suggests that once-daily regimens are as efficacious as conventional intermittent injections in the treatment of gram-negative infections including urinary tract infections, cyst

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Girton, Richard A., David P. Sundin, and Mark E. Rosenberg. "Clusterin protects renal tubular epithelial cells from gentamicin-mediated cytotoxicity." American Journal of Physiology-Renal Physiology 282, no. 4 (2002): F703—F709. http://dx.doi.org/10.1152/ajprenal.00060.2001.

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Clusterin is a heterodimeric secreted glycoprotein that is upregulated after acute renal injury. In aminoglycoside nephrotoxicity, clusterin is induced in the tubular epithelium and increased levels are found in the urine. In this study, we developed an in vitro model of gentamicin-induced cytotoxicity in renal proximal tubule cells and tested whether clusterin protected these cells from injury. LLC-PK1 cells were incubated with varying concentrations of gentamicin in serum-free media, and cytotoxicity was quantified by lactate dehydrogenase release and confirmed by vital dye exclusion. A dose

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Reena Rajan. "Mechanism of Drug Resistance in Enterococci and Therapeutic Options - A Review." International Journal of Research in Pharmaceutical Sciences 12, no. 1 (2021): 102–6. http://dx.doi.org/10.26452/ijrps.v12i1.3942.

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Enterococci exhibit an array of ways for constitutional and extrinsic resistance to primary antimicrobial agents available for clinical use. Susceptibility of these agents to β lactams, aminoglycosides or glycopeptides antibiotics or low susceptibility to combination of these agents, monomicrobial or polymicrobial nature of the infection, the involvement of heart valves or other endovascular structures affects therapy of Enterococcal infection. Vancomycin-resistant phenotypes A and B are most prevalent among medically important Enterococci isolates. Due to poor uptake of aminoglycosides, moder

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18

Elkins, Christopher A., and Lisa B. Mullis. "Bile-Mediated Aminoglycoside Sensitivity in Lactobacillus Species Likely Results from Increased Membrane Permeability Attributable to Cholic Acid." Applied and Environmental Microbiology 70, no. 12 (2004): 7200–7209. http://dx.doi.org/10.1128/aem.70.12.7200-7209.2004.

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ABSTRACT Few studies have been conducted on antimicrobial resistance in lactobacilli, presumably because of their nonpathogenic nature as anaerobic commensals. We assessed resistance in 43 type strains and isolates representing 14 species by using agar disk diffusion and MIC analysis in MRS medium. Most noteworthy were two general phenotypes displayed by nearly every strain tested: (i) they were more susceptible (up to 256-fold in some cases) to the deconjugated bile acid cholic acid than to the conjugate taurocholic or taurodeoxycholic acid, and (ii) they became susceptible to aminoglycosides

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19

Sandoval, Ruben M., Robert L. Bacallao, Kenneth W. Dunn, Jeffrey D. Leiser, and Bruce A. Molitoris. "Nucleotide depletion increases trafficking of gentamicin to the Golgi complex in LLC-PK1 cells." American Journal of Physiology-Renal Physiology 283, no. 6 (2002): F1422—F1429. http://dx.doi.org/10.1152/ajprenal.00095.2002.

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Having shown rapid trafficking of aminoglycosides to the Golgi complex in cell culture, we focused on the injurious interaction that occurs when gentamicin administration is preceded by renal ischemia. Using Texas red-labeled gentamicin as a tracer, we determined that 15 min of cellular nucleotide depletion did not significantly increase subsequent uptake. However, cells previously depleted of nucleotides accumulated significantly more Texas red-labeled gentamicin within a dispersed Golgi complex. Using Ricinus communis and Lens culinaris lectins, which label specific compartments of the Golgi

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Lindgren, Helena, and Anders Sjöstedt. "Gallium Potentiates the Antibacterial Effect of Gentamicin against Francisella tularensis." Antimicrobial Agents and Chemotherapy 60, no. 1 (2015): 288–95. http://dx.doi.org/10.1128/aac.01240-15.

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ABSTRACTThe reasons why aminoglycosides are bactericidal have not been not fully elucidated, and evidence indicates that the cidal effects are at least partly dependent on iron. We demonstrate that availability of iron markedly affects the susceptibility of the facultative intracellular bacteriumFrancisella tularensisstrain SCHU S4 to the aminoglycoside gentamicin. Specifically, the intracellular depots of iron were inversely correlated to gentamicin susceptibility, whereas the extracellular iron concentrations were directly correlated to the susceptibility. Further proof of the intimate link

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Acosta, Iván Camilo, Leonardo Posada, Mónica Gabriela Huertas, and María Mercedes Zambrano Eder. "The effect of aminoglycosides on horizontal gene transfer in Klebsiella pneumoniae." Revista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturales 44, no. 170 (2020): 105–20. http://dx.doi.org/10.18257/raccefyn.985.

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Antibiotic-resistant bacteria represent a global risk to public health. Horizontal gene transfer, a common mechanism for genetic exchange in bacteria, plays an essential role in the acquisition of resistance genes. In this work, we evaluated the effect of sub-lethal concentrations of antibiotics on plasmid transfer by conjugation and transformation in the opportunistic pathogen Klebsiella pneumoniae. Despite not being naturally competent, this bacterium could acquire extracellular DNA from various plasmids at a very low frequency, which increased upon incubating cells with the aminoglycoside a

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Jiang, Meiyan, Qi Wang, Takatoshi Karasawa, Ja-Won Koo, Hongzhe Li, and Peter S. Steyger. "Sodium-Glucose Transporter-2 (SGLT2; SLC5A2) Enhances Cellular Uptake of Aminoglycosides." PLoS ONE 9, no. 9 (2014): e108941. http://dx.doi.org/10.1371/journal.pone.0108941.

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Andrade, Jacqueline C., Maria Flaviana B. Morais Braga, Gláucia Morgana M. Guedes, et al. "Cholecalciferol, Ergosterol, and Cholesterol Enhance the Antibiotic Activity of Drugs." International Journal for Vitamin and Nutrition Research 88, no. 5-6 (2018): 244–50. http://dx.doi.org/10.1024/0300-9831/a000268.

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Abstract. Background: This is the first report demonstrating the antibiotic-modifying activity of cholecalciferol. Aim: In this study, cholecalciferol was evaluated against multiresistant strains of Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Methods: The antibacterial and modulatory effects of cholecalciferol, ergosterol, and cholesterol (8–512 μg/mL) were evaluated by microdilution assay against multiresistant bacterial strains. Results: Cholecalciferol, when combined with aminoglycosides, was more effective against P. aeruginosa, reducing the concentration of amikac

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McKay, Susannah L., and Daniel A. Portnoy. "Ribosome Hibernation Facilitates Tolerance of Stationary-Phase Bacteria to Aminoglycosides." Antimicrobial Agents and Chemotherapy 59, no. 11 (2015): 6992–99. http://dx.doi.org/10.1128/aac.01532-15.

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ABSTRACTUpon entry into stationary phase, bacteria dimerize 70S ribosomes into translationally inactive 100S particles by a process called ribosome hibernation. Previously, we reported that the hibernation-promoting factor (HPF) ofListeria monocytogenesis required for 100S particle formation and facilitates adaptation to a number of stresses. Here, we demonstrate that HPF is required for the high tolerance of stationary-phase cultures to aminoglycosides but not to beta-lactam or quinolone antibiotics. The sensitivity of a Δhpfmutant to gentamicin was suppressed by the bacteriostatic antibiotic

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Ahmed, Maizbha Uddin, Jian Li, and Qi (Tony) Zhou. "Tobramycin Reduces Pulmonary Toxicity of Polymyxin B via Inhibiting the Megalin-Mediated Drug Uptake in the Human Lung Epithelial Cells." Pharmaceutics 16, no. 3 (2024): 389. http://dx.doi.org/10.3390/pharmaceutics16030389.

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Accumulation of polymyxins in the lung epithelial cells can lead to increased mitochondrial oxidative stress and pulmonary toxicity. Aminoglycosides and polymyxins are used, via intravenous and pulmonary delivery, against multidrug-resistant Gram-negative pathogens. Our recent in vitro and animal studies demonstrated that the co-administration of polymyxins with aminoglycosides decreases polymyxin-induced pulmonary toxicity. The aim of this study was to investigate the in vitro transport and uptake of polymyxin B and tobramycin in human lung epithelial Calu-3 cells and the mechanism of reduced

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Lopes, Luma Clarindo, Muhammad Hayat, and Sabine Kuss. "Electrochemical Detection of Tobramycin Resistance in Pseudomonas Aeruginosa." ECS Meeting Abstracts MA2022-01, no. 43 (2022): 1858. http://dx.doi.org/10.1149/ma2022-01431858mtgabs.

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Pseudomonas aeruginosa are Gram-negative anaerobic bacteria and is listedby the World Health Organization as one of the critical antibiotic-resistant pathogens1. The treatment for P. aeruginosa infection can be challenging, since this pathogen often exhibits an enhanced resistance to antibiotics, including aminoglycosides, such as Tobramycin (TOB). These are called mucoid strains and are mainly found in the lungs of cystic fibrosis patients, where it is a common cause of death for these individuals2. The overall goal of the presented work is the development of an electrochemical method capable

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Mironov, Alexander, Tatyana Seregina, Konstantin Shatalin, Maxim Nagornykh, Rustem Shakulov, and Evgeny Nudler. "CydDC functions as a cytoplasmic cystine reductase to sensitizeEscherichia colito oxidative stress and aminoglycosides." Proceedings of the National Academy of Sciences 117, no. 38 (2020): 23565–70. http://dx.doi.org/10.1073/pnas.2007817117.

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l-cysteine is the source of all bacterial sulfurous biomolecules. However, the cytoplasmic level ofl-cysteine must be tightly regulated due to its propensity to reduce iron and drive damaging Fenton chemistry. It has been proposed that inEscherichia colithe component of cytochromebd-I terminal oxidase, the CydDC complex, shuttles excessivel-cysteine from the cytoplasm to the periplasm, thereby maintaining redox homeostasis. Here, we provide evidence for an alternative function of CydDC by demonstrating that thecydDphenotype, unlike that of the bona fidel-cysteine exportereamA, parallels that o

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Decorti, Giuliana, Luigi Candussio, Fiora Bartoli Klugmann, and Luciano Baldini. "Effect of Neomycin and Other Aminoglycosides on Adriamycin Uptake in Rat Peritoneal Mast Cells." Pharmacology & Toxicology 73, no. 6 (1993): 341–43. http://dx.doi.org/10.1111/j.1600-0773.1993.tb01362.x.

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Li, Hongzhe, Yongchuan Chai, and Liana Sargsyan. "Otitis media-induced cochlear immune response and opportunistic ototoxicity." Journal of the Acoustical Society of America 151, no. 4 (2022): A147. http://dx.doi.org/10.1121/10.0010925.

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Lipopolysaccharide (LPS), an essential component of the bacterial endotoxin, activates tissue macrophages and triggers the release of inflammatory cytokines. In animal models, intratympanic ( i.t.) injection of LPS is known to simulate acute otitis media (AOM) and modifies the structure and function of the inner ear. However, whether LPS-induced AOM modulates the uptake of ototoxic aminoglycosides in vivo is unclear. Here, we established an AOM mouse model to investigate the gentamicin uptake in the inner ear and the change of cochlear inflammation for pertaining ototoxicity mechanisms. We fou

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Lui, Eric Chi-Chung, and Reina Bendayan. "Gentamicin uptake by LLCPK1 cells: effect of intracellular and extracellular pH changes." Canadian Journal of Physiology and Pharmacology 76, no. 2 (1998): 155–60. http://dx.doi.org/10.1139/y98-008.

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The mechanisms by which aminoglycosides are transported across the luminal membrane of renal proximal tubular cells remain unclear. A luminal organic cation/H+ exchange as well as an adsorptive endocytosis membrane process has been proposed to be involved in gentamicin renal accumulation. The objectives of this work were to explore further the effects of intracellular and extracellular pH changes on gentamicin uptake. [3H]Gentamicin uptake by a continuous renal epithelial cell line, LLCPK1, grown as a monolayer on an impermeable surface was measured at different temperatures and pH conditions

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Kang, Hyung Sub, Dirk Kerstan, Long-jun Dai, Gordon Ritchie, and Gary A. Quamme. "Aminoglycosides inhibit hormone-stimulated Mg²⁺ uptake in mouse distal convoluted tubule cells." Canadian Journal of Physiology and Pharmacology 78, no. 8 (2000): 595–602. http://dx.doi.org/10.1139/cjpp-78-8-595.

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Deng, Wanyan, Tiwei Fu, Zhen Zhang, et al. "L-lysine potentiates aminoglycosides against Acinetobacter baumannii via regulation of proton motive force and antibiotics uptake." Emerging Microbes & Infections 9, no. 1 (2020): 639–50. http://dx.doi.org/10.1080/22221751.2020.1740611.

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Aslangul, Elisabeth, Laurent Massias, Alain Meulemans, et al. "Acquired Gentamicin Resistance by Permeability Impairment in Enterococcus faecalis." Antimicrobial Agents and Chemotherapy 50, no. 11 (2006): 3615–21. http://dx.doi.org/10.1128/aac.00390-06.

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ABSTRACT Enterococci are intrinsically resistant to low levels of aminoglycosides. We previously selected in vitro and in vivo Enterococcus faecalis with intermediate-level resistance to gentamicin that did not abolish synergism with a cell-wall-active agent (E. Aslangul et al., Antimicrob. Agents Chemother. 49:4144-4148, 2005). The aim of this study was to investigate the mechanism of resistance to gentamicin in the 1688-G3 third-step mutant (MIC, 512 μg/ml) of E. faecalis JH2-2. No mutations were found in the genes for L6 ribosomal protein and the four copies of 16S rRNA. Production of a kno

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Kocúreková, Tímea, Lívia Karahutová, and Dobroslava Bujňáková. "Antimicrobial Susceptibility and Detection of Virulence-Associated Genes in Escherichia coli Strains Isolated from Commercial Broilers." Antibiotics 10, no. 11 (2021): 1303. http://dx.doi.org/10.3390/antibiotics10111303.

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The aim of this study was to investigate the presence of iron-uptake and virulence genes, antibiotic resistance profiles, and phylogenetic relatedness in 115 Escherichia coli (E. coli) strains isolated from broilers in Slovakia and to determine their potential threat to human health. The most frequent phylogroups were B1 (37%) and A (21%), and 33.9% strains were included in pathogenic groups. The commonly observed iron-uptake genes were feoB (94%), sitA (83%), and iutA (58%). Protectins (iss, kpsMTII) were identified in 30% of samples. Four percent of B2-associated broilers carried the papC (P

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Takahashi, Masayuki, Yukihiko Aramaki, Asaichi Inaba, and Seishi Tsuchiya. "Inhibition of alkaline phosphatase activity and d-glucose uptake in rat renal brush-border membrane vesicles by aminoglycosides." Biochimica et Biophysica Acta (BBA) - Biomembranes 903, no. 1 (1987): 31–36. http://dx.doi.org/10.1016/0005-2736(87)90152-0.

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Leyton, Benjamin, Juliana Nunes Ramos, Paulo Victor Pereira Baio, et al. "Treat Me Well or Will Resist: Uptake of Mobile Genetic Elements Determine the Resistome of Corynebacterium striatum." International Journal of Molecular Sciences 22, no. 14 (2021): 7499. http://dx.doi.org/10.3390/ijms22147499.

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Corynebacterium striatum, a bacterium that is part of the normal skin microbiota, is also an opportunistic pathogen. In recent years, reports of infections and in-hospital and nosocomial outbreaks caused by antimicrobial multidrug-resistant C. striatum strains have been increasing worldwide. However, there are no studies about the genomic determinants related to antimicrobial resistance in C. striatum. This review updates global information related to antimicrobial resistance found in C. striatum and highlights the essential genomic aspects in its persistence and dissemination. The resistome o

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Kwon, Dong H., and Chung-Dar Lu. "Polyamines Induce Resistance to Cationic Peptide, Aminoglycoside, and Quinolone Antibiotics in Pseudomonas aeruginosa PAO1." Antimicrobial Agents and Chemotherapy 50, no. 5 (2006): 1615–22. http://dx.doi.org/10.1128/aac.50.5.1615-1622.2006.

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ABSTRACT Pseudomonas aeruginosa, a gram-negative bacterium of human pathogens, is noted for its environmental versatility, enormous metabolic capacity, and resistance to antibiotics. Overexpression of the outer membrane protein OprH and increased resistance to polycationic peptide antibiotics (e.g., polymyxin B) mediated by the PhoPQ two-component system on induction of a putative lipopolysaccharide (LPS) modification operon (PA3552-PA3559) have been reported as part of the adaptive responses to magnesium limitation in P. aeruginosa. Induction of the oprH-phoPQ operon and the LPS modification

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Boudville, Neil, David W. Johnson, Junhui Zhao, et al. "Regional variation in the treatment and prevention of peritoneal dialysis-related infections in the Peritoneal Dialysis Outcomes and Practice Patterns Study." Nephrology Dialysis Transplantation 34, no. 12 (2018): 2118–26. http://dx.doi.org/10.1093/ndt/gfy204.

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AbstractBackgroundPeritoneal dialysis (PD)-related infections lead to significant morbidity. The International Society for Peritoneal Dialysis (ISPD) guidelines for the prevention and treatment of PD-related infections are based on variable evidence. We describe practice patterns across facilities participating in the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS).MethodsPDOPPS, a prospective cohort study, enrolled nationally representative samples of PD patients in Australia/New Zealand (ANZ), Canada, Thailand, Japan, the UK and the USA. Data on PD-related infection prevent

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Lv, Boyan, Mengmeng Bian, Xuebing Huang, et al. "n-Butanol Potentiates Subinhibitory Aminoglycosides against Bacterial Persisters and Multidrug-Resistant MRSA by Rapidly Enhancing Antibiotic Uptake." ACS Infectious Diseases 8, no. 2 (2022): 373–86. http://dx.doi.org/10.1021/acsinfecdis.1c00559.

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Stead, D. A., and R. M. E. Richards. "Sensitive high-performance liquid chromatographic assay for aminoglycosides in biological matrices enables the direct estimation of bacterial drug uptake." Journal of Chromatography B: Biomedical Sciences and Applications 693, no. 2 (1997): 415–21. http://dx.doi.org/10.1016/s0378-4347(97)00032-7.

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Henry-Stanley, Michelle J., Donavon J. Hess, and Carol L. Wells. "Aminoglycoside inhibition of Staphylococcus aureus biofilm formation is nutrient dependent." Journal of Medical Microbiology 63, no. 6 (2014): 861–69. http://dx.doi.org/10.1099/jmm.0.068130-0.

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Biofilms represent microbial communities, encased in a self-produced matrix or extracellular polymeric substance. Microbial biofilms are likely responsible for a large proportion of clinically significant infections and the multicellular nature of biofilm existence has been repeatedly associated with antibiotic resistance. Classical in vitro antibiotic-susceptibility testing utilizes artificial growth media and planktonic microbes, but this method may not account for the variability inherent in environments subject to biofilm growth in vivo. Experiments were designed to test the hypothesis tha

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Chopra, I. "Molecular mechanisms involved in the transport of antibiotics into bacteria." Parasitology 96, S1 (1988): S25—S44. http://dx.doi.org/10.1017/s0031182000085966.

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SUMMARYMany clinically useful antibacterial drugs have intracellular target sites. Therefore, in order to reach their targets, these compounds must be able to cross bacterial outer and cytoplasmic membranes. Considerable information is available on the mechanisms by which antibiotics cross bacterial membranes and, in many cases, it is now possible to define the molecular basis of their uptake. Passage of drugs across the outer membrane of Gram-negative bacteria can occur by diffusion through porin channels (e.g. β-lactams and tetracyclines), by facilitated diffusion using specific carriers (e.

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Lade, Harshad, Hwang-Soo Joo та Jae-Seok Kim. "Molecular Basis of Non-β-Lactam Antibiotics Resistance in Staphylococcus aureus". Antibiotics 11, № 10 (2022): 1378. http://dx.doi.org/10.3390/antibiotics11101378.

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Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most successful human pathogens with the potential to cause significant morbidity and mortality. MRSA has acquired resistance to almost all β-lactam antibiotics, including the new-generation cephalosporins, and is often also resistant to multiple other antibiotic classes. The expression of penicillin-binding protein 2a (PBP2a) is the primary basis for β-lactams resistance by MRSA, but it is coupled with other resistance mechanisms, conferring resistance to non-β-lactam antibiotics. The multiplicity of resistance mechanisms includ

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Griffith, J. K., T. Kogoma, D. L. Corvo, W. L. Anderson, and A. L. Kazim. "An N-terminal domain of the tetracycline resistance protein increases susceptibility to aminoglycosides and complements potassium uptake defects in Escherichia coli." Journal of Bacteriology 170, no. 2 (1988): 598–604. http://dx.doi.org/10.1128/jb.170.2.598-604.1988.

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Cheewapat, Rattiya, Jadsadaporn Redkimned, Sirikran Lekuthai, et al. "Genomic Landscape Reveals Chromosomally-Mediated Antimicrobial Resistome and Virulome of a High-Risk International Clone II Acinetobacter baumannii AB073 from Thailand." Global Health, Epidemiology and Genomics 2024 (April 30, 2024): 1–10. http://dx.doi.org/10.1155/2024/8872463.

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This study utilized integrative bioinformatics’ tools together with phenotypic assays to understand the whole-genome features of a carbapenem-resistant international clone II Acinetobacter baumannii AB073. Overall, we found the isolate to be resistant to seven antibiotic classes, penicillins, β-lactam/β-lactamase inhibitor combinations, cephalosporins, carbapenems, aminoglycosides, fluoroquinolones, and folate pathway antagonists. These resistance phenotypes are related to various chromosomal-located antibiotic resistance determinants involved in different mechanisms such as reduced permeabili

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Williams-Hart, Tara, Xiaolin Wu, and Kelly Tatchell. "Protein Phosphatase Type 1 Regulates Ion Homeostasis in Saccharomyces cerevisiae." Genetics 160, no. 4 (2002): 1423–37. http://dx.doi.org/10.1093/genetics/160.4.1423.

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Abstract Protein phosphatase type 1 (PP1) is encoded by the essential gene GLC7 in Saccharomyces cerevisiae. glc7-109 (K259A, R260A) has a dominant, hyperglycogen defect and a recessive, ion and drug sensitivity. Surprisingly, the hyperglycogen phenotype is partially retained in null mutants of GAC1, GIP2, and PIG1, which encode potential glycogen-targeting subunits of Glc7. The R260A substitution in GLC7 is responsible for the dominant and recessive traits of glc7-109. Another mutation at this residue, glc7-R260P, confers only salt sensitivity, indicating that the glycogen and salt traits of

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Omenako, Kwaku Anim, Anthony Enimil, Afia Frimpomaa Asare Marfo, et al. "Pattern of Antimicrobial Susceptibility and Antimicrobial Treatment of Neonates Admitted with Suspected Sepsis in a Teaching Hospital in Ghana, 2021." International Journal of Environmental Research and Public Health 19, no. 19 (2022): 12968. http://dx.doi.org/10.3390/ijerph191912968.

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Neonatal sepsis is a life-threatening emergency, and empirical antimicrobial prescription is common. In this cross-sectional study of neonates admitted with suspected sepsis in a teaching hospital in Ghana from January–December 2021, we described antimicrobial prescription patterns, compliance with national standard treatment guidelines (STG), blood culture testing, antimicrobial resistance patterns and treatment outcomes. Of the 549 neonates admitted with suspected sepsis, 283 (52%) were males. Overall, 529 (96%) received empirical antimicrobials. Most neonates (n = 407, 76.9%) were treated e

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Kurabayashi, Kumiko, Koichi Tanimoto, Shinobu Fueki, Haruyoshi Tomita, and Hidetada Hirakawa. "Elevated Expression of GlpT and UhpT via FNR Activation Contributes to Increased Fosfomycin Susceptibility in Escherichia coli under Anaerobic Conditions." Antimicrobial Agents and Chemotherapy 59, no. 10 (2015): 6352–60. http://dx.doi.org/10.1128/aac.01176-15.

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ABSTRACTBecause a shortage of new antimicrobial agents is a critical issue at present, and with the spread of multidrug-resistant (MDR) pathogens, the use of fosfomycin to treat infections is being revisited as a “last-resort option.” This drug offers a particular benefit in that it is more effective against bacteria growing under oxygen-limited conditions, unlike other commonly used antimicrobials, such as fluoroquinolones and aminoglycosides. In this study, we showed thatEscherichia colistrains, including enterohemorrhagicE. coli(EHEC), were more susceptible to fosfomycin when grown anaerobi

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Fursova, Nadezhda K., Mikhail V. Fursov, Evgeny I. Astashkin, et al. "Multidrug-Resistant and Extensively Drug-Resistant Acinetobacter baumannii Causing Nosocomial Meningitis in the Neurological Intensive Care Unit." Microorganisms 11, no. 8 (2023): 2020. http://dx.doi.org/10.3390/microorganisms11082020.

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Acinetobacter baumannii is one of the significant healthcare-associated meningitis agents characterized by multidrug resistance and a high mortality risk. Thirty-seven A. baumannii strains were isolated from thirty-seven patients of Moscow neuro-ICU with meningitis in 2013–2020. The death rate was 37.8%. Strain susceptibility to antimicrobials was determined on the Vitek-2 instrument. Whole-genome sequencing was conducted using Illumina technology; the sequence types (ST), capsular types (KL), lipooligosaccharide outer core locus (OCL), antimicrobial resistance genes, and virulence genes were

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Borodina, Irina, Charlotte Schöller, Anna Eliasson, and Jens Nielsen. "Metabolic Network Analysis of Streptomyces tenebrarius, a Streptomyces Species with an Active Entner-Doudoroff Pathway." Applied and Environmental Microbiology 71, no. 5 (2005): 2294–302. http://dx.doi.org/10.1128/aem.71.5.2294-2302.2005.

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ABSTRACT Streptomyces tenebrarius is an industrially important microorganism, producing an antibiotic complex that mainly consists of the aminoglycosides apramycin, tobramycin carbamate, and kanamycin B carbamate. When S. tenebrarius is used for industrial tobramycin production, kanamycin B carbamate is an unwanted by-product. The two compounds differ only by one hydroxyl group, which is present in kanamycin carbamate but is reduced during biosynthesis of tobramycin. 13C metabolic flux analysis was used for elucidating connections between the primary carbon metabolism and the composition of th

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