Dissertationen zum Thema „Amidoamine“
Geben Sie eine Quelle nach APA, MLA, Chicago, Harvard und anderen Zitierweisen an
Machen Sie sich mit Top-42 Dissertationen für die Forschung zum Thema "Amidoamine" bekannt.
Neben jedem Werk im Literaturverzeichnis ist die Option "Zur Bibliographie hinzufügen" verfügbar. Nutzen Sie sie, wird Ihre bibliographische Angabe des gewählten Werkes nach der nötigen Zitierweise (APA, MLA, Harvard, Chicago, Vancouver usw.) automatisch gestaltet.
Sie können auch den vollen Text der wissenschaftlichen Publikation im PDF-Format herunterladen und eine Online-Annotation der Arbeit lesen, wenn die relevanten Parameter in den Metadaten verfügbar sind.
Sehen Sie die Dissertationen für verschiedene Spezialgebieten durch und erstellen Sie Ihre Bibliographie auf korrekte Weise.
Martello, F. „Poly(amidoamine)s of biotechnological interest“. Doctoral thesis, Università degli Studi di Milano, 2008. http://hdl.handle.net/2434/59949.
Der volle Inhalt der QuelleRichter-Egger, Dana L. „Spectroscopic investigations of poly(amidoamine) and poly(propyleneimine) dendrimers /“. free to MU campus, to others for purchase, 2001. http://wwwlib.umi.com/cr/mo/fullcit?p3025648.
Der volle Inhalt der QuelleHe, Min. „Immobilization of poly(amidoamine), PAMAM, dendrimers on zirconia chromatographic support“. Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0004/MQ59813.pdf.
Der volle Inhalt der QuelleJones, Nicholas Andrew. „DNA-poly(amidoamine) complexes for gene delivery : a physicochemical description“. Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299707.
Der volle Inhalt der QuelleGargiuli, Joseph Fernand. „Synthesis and modification of water-soluble hyperbranched poly(amidoamine)s“. Thesis, Durham University, 2002. http://etheses.dur.ac.uk/3871/.
Der volle Inhalt der QuelleREIS, G. A. LINO DOS. „Microfabrication and characterization of cellon-chip platforms on poly (amidoamine) hydrogels“. Doctoral thesis, Università degli Studi di Milano, 2010. http://hdl.handle.net/2434/148436.
Der volle Inhalt der QuelleBitto, Alexandro [Verfasser], und Rolf [Akademischer Betreuer] Mülhaupt. „Cellulose-Nanofüllstoffe und mehrfunktionelle Bio-Amidoamine für thermoplastische Biocompounds und isocyanatfreie Polyurethane“. Freiburg : Universität, 2011. http://d-nb.info/112346474X/34.
Der volle Inhalt der QuelleHill, P. „Biological characterisation of poly(amidoamine)s as DNA carriers for gene therapy“. Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285644.
Der volle Inhalt der QuelleRichardson, Simon Clifford Wainwright. „Characterisation of poly(amidoamine)s and chitosan as potential intracytoplasmic delivery systems“. Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369187.
Der volle Inhalt der QuelleRippey, Julie M. „Spectroscopic investigations of acrylodan dye interactions with poly(amidoamine) and poly(propyleneimine) dendrimers“. Diss., Columbia, Mo. : University of Missouri-Columbia, 2008. http://hdl.handle.net/10355/6107.
Der volle Inhalt der QuelleThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed July 13, 2009). Includes bibliographical references.
Gevorgyan, S. „NOVEL POLY(AMIDOAMINE) NANOPARTICLES DESIGNED FOR DRUG DELIVERY TO THE CENTRAL NERVOUS SYSTEM“. Doctoral thesis, Università degli Studi di Milano, 2016. http://hdl.handle.net/2434/366799.
Der volle Inhalt der QuellePollock, Neal. „The synthesis, immobilisation and characterisation of poly(amidoamine) dendrons on plasma polymer thin films“. Thesis, University of Sheffield, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500151.
Der volle Inhalt der QuelleFranckevičius, Marius. „Excited-state dynamics of PPI and PAMAM dendrimers functionalized with photochromic terminal groups“. Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2011. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20111003_114600-62082.
Der volle Inhalt der QuelleDendrimerai tai naujai dendritinių polimerų klasei priskiriamos makromolekulės. Jų dydis, funkcinių grupių skaičius yra tiksliai apibrėžti ir gali būti kontroliuojami sintezės metu. Dėl išskirtinių struktūrinių savybių, dendrimerai jau keletą dešimtmečių yra intensyviai tiriamos medžiagos. Pagrindinis disertacijos tikslas yra ištirti PPI ir PAMAM dendrimerų, funkcionalizuotų CAzPA ir ESA fotochrominiais junginiais optines savybes bei šviesa inicijuotų fotocheminių reakcijų dinamiką panaudojus kelias tyrimų metodikas. Kadangi CAzPA ir ESA junginių fotochromizmas yra susijęs su šviesa indukuota izomerizacijos bei tautomerizacijos fotocheminėmis reakcijomis, todėl darbe buvo siekiama ištirti šiais junginiais funkcionalizuotų dendrimerų dinaminių savybių priklausomybę nuo dendrimero tipo bei jo generacijos. Ištyrus PPI ir PAMAM dendrimerų funkcionalizuotų CAzPA junginiais plėvelių ir tirpalų dinamines savybes, buvo nustatyta, kad izomerizacijos sparta nepriklauso nuo dendrimero tipo, tirpiklio ir žadinančios spinduliuotės energijos. Dendrimerų plėvelių sužadintos būsenos relaksacijos trukmė yra apie 15 ps, o tai apie 7 kartus lėčiau nei tirpaluose. Eksperimentiškai ir teoriškai ištyrus skirtingų generacijų PPI dendrimerų funkcionalizuotų ESA fotochrominiais junginiais optines savybes, buvo nustatytos keturios stabilios ESA funkcinių grupių tautomerinės formos, kurių pagrindinės būsenos energijos yra skirtingos. Skirtingų dendrimero generacijų sužadintos būsenos dinamikos... [toliau žr. visą tekstą]
Franckevičius, Marius. „Sužadintos būsenos dinamika PPI ir PAMAM dendrimeruose funkcionalizuotuose fotochrominiais junginiais“. Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2011. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20111003_114348-59250.
Der volle Inhalt der QuelleDendrimers are multivalent, well-defined materials that constitute a new class of polymer macromolecules. They have been extensively studied over the past several decades mainly due to their exceptional structure properties. The size of molecule, number of terminal groups, molecular weight and several other properties of dendrimers could be precisely controlled during synthesis. The main goal of this thesis is to investigate the optical properties and light induced photochemical reaction dynamics within the PPI and PAMAM dendrimers functionalized by CAzPA and ESA type terminal groups by means of several spectroscopic techniques. Because photochromism of CAzPA and ESA type terminal groups is associated with light induced isomerization and tautomerization photochemical reactions, the main attention of present thesis was devoted to investigate dynamical properties of functionalized dendrimers as an influence of dendrimer type and its generation. Investigations of dynamic properties of PPI and PAMAM dendrimers functionalized with the CAzPA terminal groups have shown that isomerization rate is insensitive to dendrimer type, solvent and excitation wavelength. The isomerization rate of the dendrimer films take place in about 15 ps and it is only seven times slower than in dendrimer solvent. Both experimental and theoretical optical studies performed on PPI dendrimers functionalized with the ESA type terminal groups reveal four stable tautomeric forms with different energy in the... [to full text]
Hartmann, Laura. „Synthese monodisperser, multifunktionaler Poly(amidoamine) und ihre Anwendung als nicht-virale Vektoren für die Gentherapie“. Phd thesis, Universität Potsdam, 2007. http://opus.kobv.de/ubp/volltexte/2007/1312/.
Der volle Inhalt der QuelleRecently, linear poly(amidoamine)s (PAAs) have received considerable attention due to their excellent biocompatibility and ease of synthesis.[1] PAAs are multifunctional polymers, which often exhibit low inherent immunogenicity and reduced cyto- as well as hemotoxicity in contrast to established, cationic polymers such as poly(ethylene imines) (PEI) or poly(L-lysines) (PLL).[2] This makes PAAs highly suitable for biomedical and pharmacological applications in the fields of drug and gene delivery.[1,2] However, the full potential of these polymers cannot be accessed since the synthesis proceeds via an uncontrolled polyaddition reaction leading to ill-defined products with Mw/Mn ≥ 2. This does not only make rational design of polymer properties and the precise positioning of functionalities along the polymer backbone difficult, furthermore product registration becomes complicated because legislation requires increasingly more defined products. Here we present a novel synthesis route towards multifunctional, sequence-defined polyamides.[3] A fully automated, solid-phase polymer synthesis was developed and utilized to obtain linear PAA segments. These exhibit no molecular weight or chemical distributions due to their monodispersity (Mw/Mn = 1) and their controlled monomer sequence. The compatibility of the PAA-synthesis with the standard Fmoc/tBu solid-phase supported peptide synthesis has been preserved, making this route a versatile approach to peptide-PAA (Pep-PAA) and poly(ethylene oxide)-PAA (PEO-PAA) conjugates. Several Pep-PAA and PEO-PAA conjugates were synthesized, exhibiting PAA segments with different cationic functionalities. These conjugates were analyzed concerning their cytotoxicity showing very promising results. Additionally their potential to complex plasmid-DNA and to form so-called polyplexes for non-viral gene delivery was tested. A strong relationship between the monomer sequence and the polyplex structure was observed, depending on the balance and total amount of tertiary, secondary and primary amine functionalities within the PAA-segment. Moreover the monomer sequence has a strong influence on the biological properties such as the cell-internalization of polyplexes as well as the transfection activity. This clear correlation between the chemical assembly and the resulting biological properties may help to further the understanding of the mechanisms of gene delivery by polymeric carriers and hence to promote the rational design of better suited systems. Even if the transfection activity for the PAA-polpylexes might still be not comparable to the established “gold standard” PEI, their low level of toxicity and the possibility to improve the system by adjusting the monomer sequence shows great potential as carrier systems in drug or gene delivery.
Hlavinka, Mark Louis. „Dizinc organometallics based on pre-organized binucleating bis(amidoamine) ligands; synthesis, structure, and reactivity of zinc enolates“. Diss., Connect to online resource, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3207756.
Der volle Inhalt der QuelleSilva, Klaydison. „New approach to hematite recovery from ultrafine iron ore processing tailings : From fundamental studies to on-site pilot testing“. Electronic Thesis or Diss., Université de Lorraine, 2022. http://www.theses.fr/2022LORR0287.
Der volle Inhalt der QuelleThe main objective of the thesis work is to define and explain the differential behavior of hematite and silicates using more selective reagents in the reverse flotation of iron ore slimes. The proposed methodology is based on using the effects of flotation reagents to increase the recovery of fine particles from iron ore processing tailings. Spectroscopic and electrokinetic methods will make it possible to understand the difference in hydration of the mineral surface. Laboratory-scale flotation tests and molecular modeling of the mechanism of interaction between the collectors and the surface of quartz and hematite will also be carried out. Pilot tests will validate the results obtained in this multi-scale thesis work
Anthiya, Ramamoorthi Shubaash. „Development of miRNA-mimic nanoparticles for the treatment of brain tumours“. Thesis, Angers, 2016. http://www.theses.fr/2016ANGE0052/document.
Der volle Inhalt der QuelleGlioblastoma are aggressive brain tumours with a median survival of 15 months even with the best currently available treatment options. microRNAs (miRNA) are ~23 nucleotide natural silencing RNAs that have great potentials to improve cancer treatment outcomes. Lack of a safe, stable and efficient delivery system has, however, hindered the use of miRNAs inclinical applications. The aim is therefore to develop amiRNA delivery system adapted to glioblastoma using linear chain cationic polyamidoamine (PAA) polymers.The first part involved the development of luciferase assay that combined the measurement of gene-knockdown efficiency and cytotoxicity of miRNA nanoparticles. The simple two-step procedure was more effective and sensitive compared to the conventional protein-based normalization method. The second part was focused on the development of miRNA nanoparticles. In the initial phase, conditions required for maximum miRNA-polymer binding was achieved, however, the newly developed miRNA-PAA nanoparticlesdid not produce significant functional gene-knockdown after cell treatment. The second stage was focused on the optimization of nanoparticle formulation as a function of stability in physiologicalionic concentration. Stable PAA-nanoparticles displaying moderate cellular uptake and gene-knockdown were obtained. The final stage of development was focused on PAA-nanoparticle tagging with biotin, which improved their cellular uptake. This work developed simple and informative luciferase assay ; the stability of miRNA-PAA-nanoparticles was improved by thiol-crosslinking and the functional performance was strongly enhanced by a simple butsmart method of ligand tagging
Morosini, Vincent. „Pour une amélioration de la thérapie photodynamique appliquée à la cancérologie : Potentialités des dendrimères poly(amidoamine) et des Quantum Dots CdTe adressés par l'acide folique“. Phd thesis, Université Henri Poincaré - Nancy I, 2010. http://tel.archives-ouvertes.fr/tel-00547015.
Der volle Inhalt der QuelleXu, Yinhui Zhao Dongye. „Removal of copper(II) and lead(II) from soils by poly(amidoamine) dendrimers and reductive immobilization of chromium(VI) by stabilized zero-valent iron nanoparticles“. Auburn, Ala., 2006. http://repo.lib.auburn.edu/Send%208-7-07/XU_YINHUI_21.pdf.
Der volle Inhalt der QuelleFerrari, E. „POLYMERIC MATERIALS FOR THE QUANTITATIVE AND REVERSIBLE ABSORPTION OF ORGANIC AND INORGANIC WATER CONTAMINANTS“. Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/229550.
Der volle Inhalt der QuelleFenili, F. „NOVEL BIOACTIVE AND BIODEGRADABLE BIOMATERIALS OF POLY(AMIDOMINE) STRUCTURE“. Doctoral thesis, Università degli Studi di Milano, 2010. http://hdl.handle.net/2434/150128.
Der volle Inhalt der QuelleDietrich, Sascha. „(Metallo-)Dendrimers in Catalysis, Nanoparticle Stabilization and Biological Application“. Doctoral thesis, Universitätsbibliothek Chemnitz, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-82016.
Der volle Inhalt der QuelleHeldt, Jan-Martin. „Apport des dendrimères organométalliques à la mise au point d' un nouveau format d' immunodosage CMIA en phase solide“. Paris 6, 2005. http://www.theses.fr/2005PA066412.
Der volle Inhalt der QuelleRossi, E. „AN ALTERNATIVE STRATEGY FOR ADIPOSE TISSUE RECONSTRUCTION“. Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/466585.
Der volle Inhalt der QuelleAlonci, Giuseppe. „Injectable hydrogels for innovative clinical applications“. Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAF064.
Der volle Inhalt der QuelleThis thesis deals with the design of injectable hydrogels that can be used in minimally invasive surgery, such as endoscopic submucosal dissection (ESD), percutaneous hernia repair or fistulas closure.Polyamidoamines (PAAm) constitute a class of hydrogel of special interest for these purposes. After studying the different factors that affect their properties, we show that it is also possible to obtain PAAM-based microgels for applications in drug delivery or cell encapsulation.It is possible to synthesize redox-responsive nanocomposite degradable PAAm that can be injected into the submucosa of the stomach to facilitate the ESD.We show that hybrid alginate/PAAm hydrogels can be used for the percutaneous treatment of direct inguinal hernia and hydrogel-based creams have been prepared for use in fistulas closure. The last chapter of the thesis is devoted to the development of a new crosslinking strategy for hyaluronic acid in cosmetic surgery
Paes, Lorena Cristine. „Síntese e desenvolvimento de métodos analíticos para o estudo de pró-fármacos dendriméricos potencialmente ativos em doenças negligenciadas“. Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/9/9138/tde-14122016-152906/.
Der volle Inhalt der QuelleInfectious parasitoses considered neglected diseases represent a great health problem for many countries and areas. Drugs available in the therapeutics are, generally, toxics and do not have good efficacy. So, the discovery and design of new chemotherapeutic agents are extremely needed. In this context, dendrimeric prodrugs may be useful. However, additional effort is required to make the costs accessible, to simplify the synthetic strategies and to investigate the behavior of cleavage. The improvement of analytical methods, purification methods and identification of synthetic products, in order to determine the physicochemical properties and bioactivity aiming to effectively implement this technology, is also required. Based on foregoing considerations, the objective of this work was to study the identity, purity and drug release of two potential dendrimeric prodrugs, based on 3-hydroxyflavone, designed to be active in leishmaniasis and Chagas disease. The first structurally contains myo-inositol as the core and branches consisting of esters from 3-hydroxyflavone with malic acid. The second structurally contains PAMAM-G0 dendrimer (initial generation polyamidoamine) as carrier and succinic acid as spacer. Suitable analytical methods for determining 3-hydroxyflavone by HPLC-UV (High Performance Liquid Chromatography) and MEKC (Micellar Electrokinetic Chromatography) have been developed. Comparing these methods, HPLC method showed more sensitivity, precision and accuracy in the quantification of 3-hydroxyflavone, while the capillary electrophoresis method was faster and less expensive. The ester of 3-hydroxyflavone with malic acid showed to be unstable in organic and aqueous solutions, at different pH and at reaction conditions of synthetic strategies evaluated, which prevented the obtaining of dendrimer based on mio-isositol as core. Notwithstanding, PAMAM-G0 dendrimer funcionalized with 3- hydroxyflavone was synthesized, purified and characterized successfully. There were no 3- hydroxyflavone releases from this dendrimer in simulated gastric fluid (pH 1.2) and a slow release was observed in buffer solutions with pH between 5.0 and 8.5, at 37.0 ºC. Submitted to biological assays in amastigotes of two strains of T. cruzi, Y(Curitiba) and Y(SS), compared to benznidazole e nifurtimox, PAMAM-G0-SUCC-3-OH-FLAV showed moderated activity and low selectivity index.
Fuchs, Sabine. „Oberflächenfunktionalisierte Poly(amidoamin)-Dendrimere als potentielle Trägermoleküle für Cytostatika Synthese, in vitro Cytotoxizität und intrazelluläre Verteilung /“. [S.l.] : [s.n.], 2004. http://www.diss.fu-berlin.de/2004/99/index.html.
Der volle Inhalt der QuelleLee, Tzu-Chien, und 李姿蒨. „Fabrication of Pigment-Based Electrowetting Display by Polyisobutylene-Amidoamine Disperants“. Thesis, 2014. http://ndltd.ncl.edu.tw/handle/72886299508749192018.
Der volle Inhalt der Quelle國立臺灣大學
高分子科學與工程學研究所
102
In Taiwan, the development of flat display devices has advanced the panel industry into prosperity and trend, and created an economic miracle in the past. However, this industry is facing high risk low-return investment and other related problems. By applying multi-incremental-based investment strategy and improving the manufacture processing, but results were unsatisfactory. The market price margin continues to decline. The related industries begin to evolve new directions of future industry development and seek for the next opportunity to make profit. Currently, the competition of flat panel displays will turn into fierce competition. The global community has been gradually investing on R&;D for the next generation product. Many parts of flat panel displays remain to be explored and developed in this emerging market. It is possible that we could make our display industry from a high-efficient mass manufacturer into a pioneer of smart life innovation application supplier. In this thesis, a new strategy has been taken to investigate the pigment-based colorants for the basic design in the electrowetting devices. The advantages of using pigments over dyes had been realized in the development of color filters and printing industries. We synthesized a new class of oily polyisobuytylene-functionalized derivatives as the dispersants for pigment dispersions. We also fabricated for the first time the electrowetting devices and studied the high differences, environmental-friendly issue, low-cost issue, and other critical technologies. The thesis is divided in two chapters (1) Tailoring Pigment Dispersants with Polyisobutylene Twin-Tail Structures for Electrowetting Display Application: We have designed a class of highly hydrophobic dispersants for finely dispersing carbon black and organic pigment nanoparticles in highly oily mediums. The structural design and the synthesis of polymeric dispersants with oily polyisobutylene molecular tails and multiple anchoring heads is essential for homogenizing the pigment dispersion in oil/water and subsequently exhibiting a high color resolution, suitable for EWD uses. (2) First Fabrication of Electrowetting Display by Using Pigment-in-Oil Driving Pixels: We report the first fabrication of pigment particle-based electrowetting display (EWD) by using the requisite poly(isobutylene)-imide (PIB-imide) for effectively dispersing insoluble colorant in decane/water system. The series of PIB-imide dispersants were prepared from the amidation/imidation of PIB-succinic anhydride with different hydrophobic lengths and a suitable amine. The structurally tailored dispersants by adopting the highly hydrophobic PIB tails allows the formation of homogeneous dispersion of nano-sized pigment particles in decane and clearly separated from water. The pigment dispersion at particle size of ca. 100 nm and a low viscosity of 2–3 cps was obtained and fabricated into an EWD device which was operated at AC voltage driver of 15–20 V in achieving a maximum aperture ratio of 80%. With the advantage of both fast response time and vivid color, the pigment-based EWD, stands out as a promising new option for future transparent display and serves as a critical foundation for the next-generation advanced display and electrical materials applications.
Lin, Yu-Sheng, und 林侑陞. „Synthesis of Peptide Conjugated Poly(amidoamine) Dendrimer as Artifical Racemerase“. Thesis, 2010. http://ndltd.ncl.edu.tw/handle/97525607925182174395.
Der volle Inhalt der Quelle高雄醫學大學
醫藥暨應用化學研究所
98
Pyridoxal 5′-Phosphate (PLP) is the active member of of vitamin B6. PLP are known to perform numbers of reactivities in a variety of enzymes in which the lysine is a conserved residue for harboring PLP via Schiff base moiety. This is also known as external aldimine. During the course of reaction, the inbound substrate will form new Schiff base with PLP, and known as external aldimine. The exchange between external and internal aldimine is important for the demonstration of reactions. Base on the previous experimental results, we design a tripeptide involving lysine to modify the surface of PAMAM dendrimer for binding the Pyridoxal 5′-Phosphate. The designed peptides are Phe-Lys-X. The aromatic ring of phenylamine enhances the binding through PLP by?n???{???ninteraction. By the same reason, histidine, tryptophan, or tyrosine are chosen to be the third residue. During the synthesis of peptide, we found the protecting group is crucial to the solubility of those tripeptides. Those with Fmoc protecting group exhibit poor solubility. (G; 4, 5, 7)-dendri-PAMAM-(APO-Phe-Lys)n was selected for the investigation of rasemization. Under basic condition, the racemization was monitered by HPLC analysis. This result proves the ability of those synthetic dendrimers as catalyst of racemization.
Chen, Sih-Han, und 陳思翰. „The influence of surface electricity on internalization of Poly (amidoamine) dendrimers“. Thesis, 2008. http://ndltd.ncl.edu.tw/handle/69947244789927779824.
Der volle Inhalt der Quelle國立臺灣大學
醫學工程學研究所
96
Dendrimers are highly branched polymer with high density of surface functionality and core cavities. The unique architecture of dendrimers contributes to many medical application. The surface electricity of dendrimers is defined as cationic, anionic and neutral due to the functional group, amine, carboxyl and hydroxyl. The internalization of drug/gene carriers is highly interesting because it is important for designing a suitable drug/gene carrier. In this study, several endocytotic inhibitors were used to investigate the influence of surface electricity on internalization of poly (amidoamine) (PAMAM) dendrimers, and confirmed the cellular distribution of dendrimers in the presense of various endocytotic inhibitors by confocal laser scanning microscopy. The results indicate that the cellular uptakes of different PAMAM dendrimers were obviously influenced of surface functionality on the internalizations. Cationic dendrimer was shown the highest uptake by HeLa cells, while the anionic and neutral was shown rarely enter the cells. The further studies on internalization of cationic dendrimer provide a method to investigate the detail process of the attachment and further endocytosis of particle. Understanding the internalization of dendrimers may contribute to develop the modification designing for desired applications and targeting cells.
Meltzer, A. Donald. „Mobility of poly(amidoamine) dendrimers; a study of NMR relaxation times“. 1990. https://scholarworks.umass.edu/dissertations/AAI9022719.
Der volle Inhalt der QuelleChen, Sih-Han. „The influence of surface electricity on internalization of Poly (amidoamine) dendrimers“. 2008. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-3007200815240400.
Der volle Inhalt der QuelleTsai, Ching-Hua, und 蔡靜樺. „Synthesis of Poly(amidoamine) Dendrimer with Peripheral Boronic Acid as Carbohydrates Sensor“. Thesis, 2018. http://ndltd.ncl.edu.tw/handle/897xz5.
Der volle Inhalt der Quelle高雄醫學大學
醫藥暨應用化學系博士班
106
Boronic acid-containing compounds have several unique features, such as strong affinity to diols and forming reversible covalent binding. The diol-containing biomolecules, such as saccharides, glycans, glycoproteins, nucleosides, are the important recognition targets in biomedical applications. Thus, boronic acid-containing compounds are important material for the selective separation and molecular recognition of diol-containing compounds. However, monoboronic acid suffers from low affinity and poor selectivity to glucose. Diboronic acid-containing compound can selectively bind glucose with well-designed geometry between two boronic acids. The poly(amidoamine) (PAMAM) dendrimers have unique advantages, such as massive number of surface groups. These features provided exclusive behavior for cooperative effect. We envisioned the cooperative effect should assist the selective binding of glucose with monoboronic acids. PAMAM dendrimers were considered as a potential platform for selective binding to glucose. We designed highly-densed boronic acid modified PAMAM dendrimer to facilitate glucose selectivity and affinity. We prepared second to sixth generation of 4-carboxyphenylboronic acid modified PAMAM dendrimers and investigated their size-dependent ability of binding to saccharides. During the preparation, we observed that phenol-modified PAMAM dendrimers formed as a hydrolysis of boronic acid, which may resulted in the difficult preoperative in the synthesis of boronic acid modified polymer. Accordingly, we found that the main factor for the hydrolysis is a massive amount of amino groups structurally closed to boronic acid. The binding affinity of 4-carboxyphenylboronic acid-modified PAMAM dendrimer with various saccharides showed that these series of PAMAM dendrimer compounds can selectively bind glucose. The binding constant of third generation 4-carboxyphenylboronic acid-modified PAMAM dendrimers (95b) with glucose is 1963.5 M-1. The 95b has the best selectivity to glucose, and its binding ability is 72.8 times, 93.6 times, and 1310 times stronger than to those of galactose, fructose and lactose respectively. To investigate the underlying mechanism, 4-carboxyphenylboronic acid-modified PAMAM dendrimer-based analogues and glucose derivatives were subjected to the binding experiments and the results indicated that boronic acids on two adjacent branches exhibit cooperative effects for binding of two sites on glucose. For the first time, 4-carboxyphenylboronic acid-modified PAMAM dendrimers exhibited highly selective bind to glucose, such as diboronic acid. So the application of dendrimer can provide different a unique recognition mode for small molecules.
Li, Lingling. „Rheological Properties and Reaction Kinetics of Amidoamine Oxide Surfactants-based Acids with Calcite“. Thesis, 2011. http://hdl.handle.net/1969.1/ETD-TAMU-2011-05-9211.
Der volle Inhalt der QuelleHung, Wei-I., und 洪偉毅. „Synthesis and Properties of Amphiphilic Poly(amidoamine) Dendrimers with an Aniline Pentamer Shell“. Thesis, 2011. http://ndltd.ncl.edu.tw/handle/61091150965095234900.
Der volle Inhalt der Quelle中原大學
化學研究所
99
Poly(amidoamine) (PAMAM) dendrimers with different generations (G = 2, 3, 4 and 5) have been peripherally modified with aniline pentamers (AP). Their redox and dopable behavior are strongly affected by the dendritic architectures at different generations under different pH conditions. It was found that the electron transition of the πB–πQ band red-shifted and the size of PAMAM G2 decreased in an alkaline medium. The chemical oxidation process and the color change of these modified dendritic macromolecules were measured by cyclic voltammetry (CV) and electrochromism. All of the dendrimers showed three redox peaks in the CV. The current density of the voltammograms increased with increasing the number of aniline pentamer segments at the periphery. A drastic color change was observed when a linear potential sweep was applied. From thermal properties of the electroactive dendrimers, it reveals the introduction of electroactive AP on PAMAM dendrimers can improve the thermal stability of the dendrimers. These amphiphilic PAMAM dendrimers peripherally modified with hydrophobic AP shell can self-assemble into vesicular bilayer aggregates at lower (G2 & G3) and higher (G4 & G5) generations in water. The size of these vesicles are decrease with increasing generation under neutral pH. Critical aggregation concentration reveals that these aggregates can be favorably formed in the order of G5 >G4 > G3 > G2. These dendrimer-based vesicles are very adhesive due to the H-bonding interaction and entanglement of dendritic branches located in the outer layer. In addition, the different morphology and size of the bilayer assemblies have great influence on pH values of ~ 3, 7, and 9. The high pH form has a strongly π–π interaction between APs, whereas ion pairing at low pH leads to a loose structure of dendritic branches located in the outer layer, which can identifiable with transmission electron microscopy (TEM) images with negative staining. WAXRD experiments indicated that the higher generations of amphiphilic dendrimers are more order owing to APs exhibit a powerful driving force for the self-assembly.
Hartmann, Laura [Verfasser]. „Synthese monodisperser, multifunktionaler Poly(amidoamine) und ihre Anwendung als nicht-virale Vektoren für die Gentherapie / von Laura Hartmann“. 2007. http://d-nb.info/983950059/34.
Der volle Inhalt der QuelleCheng, Ming-Yu, und 鄭茗譽. „Computational study of the lowest energy conformers and spectrum of poly(amidoamine) PAMAM G0 dendrimers and it's derivative“. Thesis, 2015. http://ndltd.ncl.edu.tw/handle/24248080280367390683.
Der volle Inhalt der Quelle中原大學
化學研究所
103
Understanding the dendrimer-drug interaction is of great importance to design and optimize the dendrimer-based drug delivery system. We use the lowest generation PAMAM-G0 dendrimer to study due to the time and cost . The calculated Mulliken Atomic Charges reveals the terminal group (NH2 or OH) is easy to protonated indicating that it will let the dendrimer become toxicity. Then we try to use phosphorus (P) to substitute the nitrogen (N), we found that the Mulliken Atomic Charges become more positive , indicating that it becomes less toxicity by the substitution of N to P for dendrimer. For the second part we study the interaction between dendrimer and transition metal . We consider six configurations . Our calculation show that metal is likely to bind at the core site , and the binding energy of the metal ions have the following trend Cu > Ag > Au.
Hung, Chih-Bing, und 洪誌彬. „Morphology and Physical Properties Studies of Porous Poly(methyl methacrylate) Composite Membranes by Incorporating Different Loading and Generation of Poly(amidoamine) Dendrimers“. Thesis, 2011. http://ndltd.ncl.edu.tw/handle/27349764031822405947.
Der volle Inhalt der Quelle中原大學
化學研究所
99
In this paper, porous composite membranes were prepared via blending different generations of poly(amidoamine) (PAMAM) dendrimers with poly(methyl methacrylate) (PMMA). Phase behavior and physical properties resulted from interactions between blend components was studied, Moreover, potential application in thermal insulation materials and gas separation membranes were also investigated. First of all, a series of PAMAM dendrimers (G0 and G1) products were prepared through repeat the synthesis steps of michael addition and ester amidation. It has different sizes and different number of functional groups terminated. The as-synthesized PAMAM dendrimers were characterized by FTIR, liquid NMR and mass spectrometry (TOF-mass). PMMA with weight molecular weight (Mw) of ~ 18,000 was prepared by emulsion polymerization, then different loading and different generations of PAMAM dendrimers were blending into as-synthesized PMMA to give a series of PMMA composite membranes. Optical properties, phase behavior, thermal stability and mechanical strength of free-standing porous PMMA composite membranes was investigated by UV-visible absorption spectroscopy, SEM, DSC, TGA and DMA. It should be noted that the free-standing PMMA composite membranes exhibited good thermal insulation and gas separation based on the transient plane source (TPS) technique and gas permeability analysis (GPA) measurements, respectively.
Dietrich, Sascha. „(Metallo-)Dendrimers in Catalysis, Nanoparticle Stabilization and Biological Application“. Doctoral thesis, 2011. https://monarch.qucosa.de/id/qucosa%3A19636.
Der volle Inhalt der QuelleEl, Sabahy Mahmoud. „Polymeric micelles as versatile carriers for drugs and nucleic acids“. Thèse, 2009. http://hdl.handle.net/1866/3481.
Der volle Inhalt der QuelleCancer is considered as the leading cause of premature death in Canada. Taxanes (e.g. paclitaxel and docetaxel (DCTX)) are effective against a range of solid tumors including breast, lung, and ovarian malignancies. In addition, nucleic acids (e.g. antisense oligonucleotides (AON) and short interfering RNA (siRNA)) which are capable of selectively suppressing oncogenes involved in carcinogenesis are currently being investigated for the treatment of a wide variety of cancers. Although the activity of taxanes and nucleic acid drugs is well-established in human and/or animal models, several physicochemical and clinical issues still need to be addressed. Low aqueous solubility (i.e. taxanes), rapid degradation in the blood (i.e. nucleic acids), fast clearance, non-selectivity and toxicity to normal tissues are limiting factors to their effectiveness. Hence, many efforts have been focused on developing targeted polymeric delivery systems to overcome the problems associated with the current therapies. In this thesis, two types of polymeric micelles have been developed for the delivery of DCTX and nucleic acids. On the one hand, poly(ethylene oxide)-block-poly(butylene oxide/styrene oxide) micelles were tested for the first time to solubilize and protect DCTX from hydrolytic degradation. The polymers showed less toxicity than the surfactant used commercially to dissolve DCTX (i.e. polysorbate 80) and released the drug in a sustained fashion. On the other hand, two different systems of polyion complex micelles (PICM) were developed for the sustained release and intracellular delivery of nucleic acids. Novel poly(ethylene glycol) (PEG)-oligonucleotide conjugates were assessed to protect AON against degradation and release them in a sustained manner. When these conjugates were mixed with poly(amidoamine) (PAMAM) dendrimers, monodisperse PICM were formed. These PICM further slowed down AON release and significantly protected it against enzymatic degradation. In addition, the incorporation of poly(ethylene oxide)-block-poly(propyl methacrylate-co-methacrylic acid) was exploited to impart pH-sensitivity to PAMAM-based PICM. This system was composed of the previous copolymer mixed with PAMAM dendrimer. Such PICM were loaded with AON or siRNA targeting the Bcl-2 oncogene. Micelles uptake by the cancer cells was mediated by a monoclonal antibody fragment (i.e. Fab') positioned at the extremity of the PEG corona. Upon cellular uptake and protonation of the methacrylic acid units in the acidic endosomal environment, the micelles lost their corona, thereby exposing their positively-charged endosomolytic PAMAM/nucleic acid core. The targeted, pH-sensitive PICM were found to increase the intracellular bioavailability of the entrapped nucleic acids and knock down the Bcl-2 oncoprotein more than either non-targeted micelles or commercial PAMAM dendrimers. The polymeric nanocarriers reported in this thesis appear to be promising vehicles for the delivery of anticancer drugs and nucleic acids.
Fuchs, Sabine [Verfasser]. „Oberflächenfunktionalisierte Poly(amidoamin)-Dendrimere als potentielle Trägermoleküle für Cytostatika : Synthese, in vitro Cytotoxizität und intrazelluläre Verteilung / vorgelegt von Sabine Fuchs“. 2004. http://d-nb.info/970870396/34.
Der volle Inhalt der Quelle