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1

Sheehy, Suzanne Lyn. „Design of a non-scaling fixed field alternating gradient accelerator for charged particle therapy“. Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:d9cd977c-35db-45cc-ad33-67710fc3e82f.

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This thesis describes the design a novel type of particle accelerator for charged particle therapy. The accelerator is called a non-scaling, Fixed Field Alternating Gradient (ns-FFAG) accelerator, and will accelerate both protons and carbon ions to energies required for clinical use. The work is undertaken as part of the PAMELA project. An existing design for a ns-FFAG is taken as a starting point and analysed in terms of its ability to suit the charged particle therapy application. It is found that this design is particularly sensitive to alignment errors and would be unable to accelerate protons and carbon ions at the proposed acceleration rate due to betatron resonance crossing phenomena. To overcome this issue, a new type of non-linear ns-FFAG is developed which avoids resonance crossing and meets the requirements provided by clinical considerations. Two accelerating rings are required, one for protons up to 250 MeV and fully stripped carbon ions to 68 MeV/u, the other to accelerate the carbon ions up to 400-430 MeV/u. Detailed studies are undertaken to show that this new type of accelerator is suitable for the application. An alignment accuracy of 50 micrometers will not have a detrimental effect on the beam and the dynamic aperture for most lattice configurations is found to be greater than 50 pi.mm.mrad normalised in both the horizontal and vertical plane. Verification of the simulation code used in the PAMELA lattice design is carried out using experimental results from EMMA, the world's first ns-FFAG for 10-20 MeV electrons built at Daresbury Laboratory, UK. Finally, it is shown that the described lattice can translate into realistic designs for the individual components of the accelerator. The integration of these components into the PAMELA facility is discussed.
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2

He, Wei. „Mathematical Modeling of Therapies for MCF7 Breast Cancer Cells“. Diss., Virginia Tech, 2021. http://hdl.handle.net/10919/103967.

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Estrogen receptor (ER)-positive breast cancer is responsive to a number of targeted therapies used clinically. Unfortunately, the continuous application of any targeted therapy often results in resistance to the therapy. Our ultimate goal is to use mathematical modelling to optimize alternating therapies that not only decrease proliferation but also stave off resistance. Toward this end, we measured levels of key proteins and proliferation over a 7-day time course in ER-positive MCF7 breast cancer cells. Treatments included endocrine therapy, either estrogen deprivation, which mimics the effects of an aromatase inhibitor, or fulvestrant, an ER degrader. These data were used to calibrate a mathematical model based on key interactions between ER signaling and the cell cycle. We show that the calibrated model is capable of predicting the combination treatment of fulvestrant and estrogen deprivation. Further, we show that we can add a new drug, palbociclib, to the model by measuring only two key proteins, c-Myc and hyperphosphorylated RB1, and adjusting only parameters associated with the drug. The model is then able to predict the combination treatment of estrogen deprivation and palbociclib. Then we added the dynamics of estrogen concentration in the medium into the model and extended the short-term model to a long-term model. The long-term model can simulate various mono- or combination treatments at different doses over 28 days. In addition to palbociclib, we add another Cdk4/6 inhibitor to the model, abemaciclib, which can induce apoptosis at high concentrations. Then the model can match the effects of abemaciclib treatment at two different doses and also capture the apoptosis effects induced by abemaciclib. After calibrating the model to these different treatment conditions, we used the model to explore the synergism among these different treatments. The mathematical model predicts a significant synergism between palbociclib or abemaciclib in combination with fulvestrant. And the predicted synergisms are verified by experiments. This critical synergism between these Cdk4/6 inhibitors and endocrine therapy could reflect the reason that Cdk4/6 inhibitors achieve pronounced success in clinic trails. Lastly, we used protein biomarkers (cyclinD1, cyclinE1, Cdk4, Cdk6 and Cdk2) and palbociclib dose-response proliferation assays to assess the difference between mono- and alternating therapy after 10 weeks of treatments. But neither the protein levels nor palbociclib dose-response show significant differences after 10 weeks of treatment. Therefore, we cannot conclude that alternating therapy delays palbociclib resistance compared with palbociclib mono-treatment after 10 weeks. Longer term experiments or other methods will be needed to uncover any difference. However, in this research we showed that a mechanism-based mathematical model is able to simulate and predict various effects of clinically-used treatments on ER-positive breast cancer cells at different time scales. And this mathematical model has the potential to explore ideas for potential drug treatments, optimize protocols that limit proliferation, and determine the drugs, doses, and alternating schedule for long term experiments.
Doctor of Philosophy
Estrogen receptors are proteins found inside breast cancer cells that are activated by the hormone estrogen. Estrogen-receptor positive breast cancer is the most common type of breast cancer and accounts for about 70% of breast cancer tumors. Endocrine therapy, which inhibits estrogen receptor signaling, and Cyclin-dependent kinase 4 and 6 (Cdk4/6) inhibitors are the preferred first-line therapy for patients with estrogen receptor-positive cancers. We built a mathematical model of MCF7 cells (an estrogen receptor-positive breast cancer cell line) in response to these standard first-line therapies. This mathematical model can capture the experimentally observed protein and cell proliferation changes in response to various treatment conditions, including different drug combinations, different doses, and different treatment durations up to 28 days. The model can then be used to look for more effective treatment possibilities. In particular, our mathematical model predicted a strong synergism between Cdk4/6 inhibitors and endocrine therapy, which could allow significant reductions in drug dosage while producing the same effect. This synergism was verified by experiments. In addition to treatment methods where one drug or combination of several drugs is used continuously, we consider alternating among various therapies in a fixed cycle. The mathematical model can help us determine which drugs and which doses might be most appropriate. Since an alternating therapy doesn't inhibit one particular target non-stop, the hope is that alternating therapies can delay the onset of drug resistance, where the drug becomes less effective or stops working completely. Unfortunately, an initial 10- week experiment to test for differences in resistance to a mono-therapy versus an alternating therapy did not show a significant difference, pointing to the need for longer experiments to see if alternating therapies can actually make a difference in resistance. Mathematical models will be important for determining the drugs, doses, and time intervals to be used in these experiments, as figuring out the best options by trial and error in such long-term experiments is not practical.
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3

Boyer, Valerie E. „Animal-assisted therapy in speech-language pathology : using an alternating treatment design to compare the effects of using animal-assisted therapy in working with children with language impairments /“. Available to subscribers only, 2006. http://proquest.umi.com/pqdweb?did=1216741901&sid=4&Fmt=2&clientId=1509&RQT=309&VName=PQD.

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Thesis (Ph.D.)--Southern Illinois University Carbondale, 2006.
"Department of Educational Psychology and Special Education." Includes bibliographical references (leaves 114-118). Also available online.
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4

Amano, Tamaki. „The role of alternating bilateral stimulation in establishing positive cognition in EMDR therapy: a multi-channel near-infrared spectroscopy study“. 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225519.

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5

Schmulian, Dunay Liezel. „The development of a universal speech facilitation program as an extension of the speech motor learning program and its application in an experimental alternating treatment study“. Pretoria : [s.n.], 2000. http://upetd.up.ac.za/thesis/available/etd-07172006-130724.

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6

Parralego, Paula Alessandra Garcia Gripp. „Desenvolvimento e aplicação de um protocolo fisioterapêutico para lipodistrofia abdominal feminina por meio de técnicas eletrotermoterapêuticas“. Universidade Tecnológica Federal do Paraná, 2015. http://repositorio.utfpr.edu.br/jspui/handle/1/1925.

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No Brasil 72% dos óbitos são decorrentes de complicações destas doenças. Associado ao alto custo do Sistema Público de Saúde e elevado risco às doenças secundárias, o excesso de peso, pode ocasionar a lipodistrofia localizada, esta, caracterizada pelas poucas alternativas de tratamento, sendo o tratamento cirúrgico o mais realizado. Poucos estudos demonstram a utilização de terapia auxiliar para a redução da lipodistrofia localizada e ainda há maior restrição em pesquisas específicas visando o tratamento da lipodistrofia abdominal. O presente estudo procurou verificar os efeitos de uma terapia não invasiva, em uma região específica predisponente ao acúmulo de gordura, o abdome. Foi realizado um estudo longitudinal, de abordagem quantitativa, do tipo descritiva, composto por 33 mulheres, com acúmulo de adiposidade abdominal, na faixa etária dos 20 a 35 anos. Inicialmente todas assinaram o Termo de Consentimento Livre e Esclarecido (TCLE); sequencialmente, houve uma divisão da amostra em dois grupos: A, que realizou dez sessões seguidas do protocolo fisioterapêutico e B, que realizou cinco sessões, seguida de uma pausa e realizou outras cinco sessões do protocolo. Todas as voluntárias responderam o questionário e realizaram a primeira avaliação corporal que foi repetida após a quinta e décima sessão do protocolo fisioterapêutico além da realização do exame de Densitometria por Absorciometria de Raios X de Dupla Energia (DXA) que foi realizado ao início e término das sessões, que consistiu na aplicação abdominal de um protocolo desenvolvido baseado em associação de duas técnicas fisioterapêuticas: o ultrassom de 3MHz e a corrente alternada de média frequência. Foram analisados inicialmente os dados coletados da amostra geral seguido da análise de comparação entre os grupos A e B, para a verificação da normalidade da distribuição utilizou-se o teste de Shapiro-Wilk e para a comparação dos dados utilizou-se a ANOVA de Friedman. Os resultados encontrados para as variáveis analisadas da amostra geral: massa, perimetria de cintura, perimetria de cicatriz umbilical, perimetria da menor circunferência abdominal, perimetria da maior circunferência abdominal e percentual de gordura de tronco avaliado por meio da DXA, apresentou o valor de p<0,001 verificando uma diferença significativa comparada à avaliação inicial à final. Em relação ao percentual de gordura corporal total avaliado pela DXA, o valor de “p” foi p=0,779, demonstrando uma redução com variação de 0,1% a 2,7% entre as voluntárias. Quando comparados os grupos A e B, observou-se homogeneidade entre os grupos e não foi apresentada diferença estatística entre eles, portanto não houve alteração do resultado final. Sendo assim, este protocolo foi desenvolvido especificamente para o tratamento da lipodistrofia abdominal feminina e durante o estudo se mostrou eficaz no tratamento para redução deste tipo de adiposidade em mulheres jovens.
In Brazil the complications of these illnesses are responsible for 72% of the deaths. Overweight combined with not only the high costs of health service provided by the government, but also with the high risk of secondary diseases, can cause localized lipodystrophy which has few alternatives for treatment, being surgical treatment the most common. Few studies show the usage of adjunctive therapy in order to reduce localized lipodystrophy and still they have greater restriction in specific research aiming at the treatment of localized abdominal lipodystrophy. The objective of this study was to verify the results of a non-invasive therapy in a specific area more predisposed to fat accumulation – the abdomen. A longitudinal study was performed, using a quantitative-descriptive research composed of 33 women with abdominal fat accumulation, with an age range of 20 to 35 years old. All of them signed an informed consent term (TCLE) and the sample was divided in two groups: A, which held ten physiotherapy sessions according to the physiotherapy protocol and B, which held five physiotherapy sessions, followed by a pause, and then held other five sessions according to the protocol. All the volunteers answered a questionnaire and went through their first body evaluation, which was repeated after the fifth and tenth session according to the physiotherapy protocol. They also underwent a Dual-Energy X-ray absorptiometry (DXA) test, repeated in the beginning and in the end of the sessions, which consisted of an application of a protocol, in the abdomen, developed based on the association of two physiotherapy techniques: 3-MHz ultrasound and medium-frequency alternating current. Initially, the general sample data was analyzed, followed by the comparative analysis between groups A and B. A Shapiro- Wilk test was performed to check the normality of the distribution and ANOVA Friedman was used to compare the data. The results for the variables analyzed in general sample were: mass, waist measurement, umbilical scar measurement, narrowest abdominal circumference measurement, widest abdominal circumference measurement and midsection fat percentage p<0,001, evaluated by DXA, showing a considerable difference if compared from the initial evaluation to the final. The percentage of total body fat evaluated by DXA was p=0,779 demonstrating reduction with a variation of 0,1% to 2,7% among all the volunteers. Comparing groups A and B, homogeneity could be observed and there was no statistic difference between them. Therefore, this protocol was developed specifically for the treatment of abdominal lipodystrophy in women and during the present study it demonstrated to be efficient for the treatment of reduction for this type of adiposity in young women.
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7

Müller, Pierrette A. „Autistic children and music therapy : the influence of maternal involvement in therapy“. Thesis, University of Reading, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385078.

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8

Thurber, Shawn L. „The Effects of Direct Supervision on Therapist Behavior: A Functional Analysis“. BYU ScholarsArchive, 2005. https://scholarsarchive.byu.edu/etd/298.

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Live (Direct) Supervision has always been key to training therapists. However, little research has been done to determine which type of direct supervision is most effective in changing therapist behavior. This study compared bug-in-the-ear (BITE), phone-in, and computer assisted (CA) supervision. The purpose of this study was to (a) complete functional analysis of each supervision type via an alternating feedback session, to determine each therapists' most effective form of supervision; (b) determine the effect of using the most-effective form of supervision on the therapists' adherence to treatment protocols during follow-up sessions; (c) determine the effect of therapist adherence on client in-session behaviors, and outcome assessments. Results of the functional analysis indicated that phone-in supervisory feedback was the least effective form of supervision. BITE and CA supervision were both found to be effective for at least one therapist. In follow-up sessions BITE supervision did not create sustained changes in overall adherence. CA feedback appeared to maintain overall therapist adherence. In affecting changes to client behavior and outcome scores BITE supervision gave mixed results. CA supervision created desired changes in client behaviors and outcome assessments. For practitioners in the field, this study demonstrates that client behavior does not improve without therapist intervention. Even when client behavior in session appears to be improving, marital distress may increase. This is especially true when therapist adherence does not improve. This study further demonstrates that when the therapists did not intervene appropriately the clients either worsened, or at best, stayed the same. When the therapists made even small improvements client behavior improved. Improving adherence to treatment protocols will always serve the best interest of the client.
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9

Zupancic, Christine Lyn. „Therapy or Culture: A Comparison of the Buckhorn Model of Therapy to Other Therapeutic Models in the United States“. University of Cincinnati / OhioLINK, 2000. http://rave.ohiolink.edu/etdc/view?acc_num=ucin974918319.

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10

Bates, Nora. „Alternative healing as a complement to traditional, western therapy“. Online version, 2000. http://www.uwstout.edu/lib/thesis/2000/2000batesn.pdf.

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11

Jenkins, Mary M. „Occupational therapy : perspectives on the effectiveness of practice“. Thesis, University of Ulster, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242146.

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12

Munroe, Helena A. „Clinical reasoning in community occupational therapy : patterns and processes“. Thesis, Heriot-Watt University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315181.

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13

Lambe, Camille Eckerd Germino Barbara B. „Complementary and alternative therapy use during treatment of breast cancer“. Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2006. http://dc.lib.unc.edu/u?/etd,671.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2006.
Title from electronic title page (viewed Oct. 10, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the School of Nursing." Discipline: Nursing; Department/School: Nursing.
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14

Cheon, Hee-Sun. „Role profiles an alternative look at personality in couples therapy /“. [Ames, Iowa : Iowa State University], 2007.

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15

Gamelas, Sara Raquel Duarte. „Porphyrin derivatives and mRNA alternative splicing induced by photodynamic therapy“. Master's thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/18633.

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Mestrado em Química
Neste trabalho é descrita a síntese de porfirinas regulares e N-confusas com o objetivo da realização de estudos acerca da sua eficiência como fotossensibilizadores (PSs) em terapia fotodinâmica (PDT) e a influência desta no splicing alternativo do mRNA. Os derivados porfirinicos foram preparados tendo como estrutura base a 5,10,15,20-tetraquis(1-metilpiridinio-4-il)porfirina. Inicialmente irá ser realizada uma breve introdução sobre os macrociclos tetrapirrólicos, nomeadamente sobre porfirinas. Segue-se o capítulo 2 onde há a descrição sintética dos derivados porfirínicos usados neste trabalho. Desta forma, através das condições estabelecidas por Lindsey foram sintetizadas duas porfirinas: 5,10,15,20-tetraquis(4-bromometilfenil)-2-aza-21-carboporfirina e a 5,10,15,20-tetraquis(4-bromometilfenil)porfirina e procedendo-se à sua cationização com piridina que originou os derivados 5,10,15,20-tetraquis(4-(piridinio-1-il-metil)fenil)-2-aza-21-carboporfirina e 5,10,15,20-tetraquis(4-(piridinio-1-il-metil)fenil)porfirina. A formação das porfirinas neutras ocorreu com baixo rendimento, mas a sua cationização foi conseguida com rendimentos acima dos 80%. Neste mesmo capítulo ainda são apresentadas as caracterizações fotofísicas de todos os derivados porfirínicos, nomeadamente fluorescência e geração de oxigénio singleto. As porfirinas regulares foram aquelas que demonstraram bons rendimentos quânticos de fluorescência e capacidade para gerar oxigénio singleto em DMF. No capítulo 3 são descritos todos os estudos biológicos realizados neste trabalho. Inicialmente foram realizados estudos de viabilidade celular em células MCF-7 e HeLa usando o teste com WST-1 e ATPliteTM e como PS de referência a 5,10,15,20-tetraquis(1-metilpiridinio-4-il)porfirina. Foram realizados estudos de concentração (0.1 μM-5.0 μM) e tempo de irradiação (0, 5, 10 e 15 min). A 5,10,15,20-tetraquis(4-(piridinio-1-il-metil)fenil)porfirina revelou ser o melhor PS, tendo sido selecionado um tempo de irradiação de 15 min e uma concentração até 5 μM para o estudos subsequentes. Os estudos de localização subcelular e uptake revelaram que a 5,10,15,20-tetraquis(4-(piridinio-1-il-metil)fenil)porfirina entra nas células mas não se localiza no núcleo como acontece com o controlo positivo. São ainda descritos estudos acerca do tipo de morte celular que as células podem sofrer depois da PDT com estes PSs. Por fim os estudos da influência da terapia fotodinâmica no splicing alternativo mostrou que a 5,10,15,20-tetraquis(4-(piridinio-1-il-metil)fenil)porfirina e a 5,10,15,20-tetraquis(1-metilpiridinio-4-il)porfirina parecem induzir um ligeiro splicing alternativo do mRNA.
In this work the synthesis of regular and N- confused porphyrins with the objective of assessing its efficiency as photosensitizers (PSs) in photodynamic therapy (PDT) and its influence in alternative splicing of mRNA is described. The porphyrin derivatives were prepared having as a template the 5,10,15,20-tetrakis(1-methylpyridynium-4-yl)porphyrin. Initially, a brief introduction about tetrapyrrolic macrocycles, namely about porphyrins will be done. Then, chapter 2 will follow with the synthetic description of the porphyrin derivatives used in this work. Through Lindsey conditions, two porphyrins were synthesized: 5,10,15,20-tetrakis(4-bromomethylphenyl)-2-aza-21-carbaporphyrin; 5,10,15,20-tetrakis(4-bromomethylphenyl)porphyrin and then we proceeded to their cationization with pyridine to give: 5,10,15,20-tetrakis(4-(pyridynium-1-yl-methyl)phenyl)-2-aza-21-carbaporphyrin and 5,10,15,20-tetrakis(4-(pyridynium-1-yl-methyl)phenyl)porphyrin. The formation of the neutral porphyrins occurred with low yield but its cationization was achieved with yields higher than 80%. In the same chapter, the photophysical characterization of all porphyrins, namely singlet oxygen production and fluorescence quantum yield were described. The regular porphyrins demonstrated good fluorescence quantum yields and ability to generate singlet oxygen in DMF. In chapter 3, all the biological assays done in this work are described. Initially, cellular viability studies were done in MCF-7 and HeLa cells using the WST-1 reagent and ATPliteTM and as PSs reference the 5,10,15,20-tetrakis(1-methylpyridynium-4-yl)porphyrin. Studies of concentration (0.1 μM-5.0 μM) and irradiation time (0, 5, 10 and 15 min) were also done. The 5,10,15,20-tetrakis(4-(pyridynium-1-yl-methyl)phenyl)porphyrin showed to be the best PS and 15 min irradiation and a concentration up to 5 μM for the following studies were selected. The subcellular localization and uptake studies revealed that 5,10,15,20-tetrakis(4-(pyridynium-1-yl-methyl)phenyl)porphyrin can enter the cells but it is not localized in the nucleus, contrary to 5,10,15,20-tetrakis(1-methylpyridynium-4-yl)porphyrin. The studies regarding type of cell death that cells undergo after PDT treatment were also assessed. At last, the 5,10,15,20-tetrakis(4-(pyridynium-1-yl-methyl)phenyl)porphyrin and 5,10,15,20-tetrakis(1-methylpyridynium-4-yl)porphyrin seemed to induce a small alternative splicing of mRNA.
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16

Smith, Grace Elaine. „A randomised controlled clinical trial of reflexology in breast cancer patients, to reduce fatigue resulting from radiotherapy to the breast and chest wall“. Thesis, University of Liverpool, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268926.

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17

Williams, Duane, Patsy Cantor, Jennifer Williams, Courtney D. Hall, N. Brown, Ryan Dulling und Ogechi Egbujor. „Reliability of Two Alternative Methods for the Standard Mid-Thigh Pull“. Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etsu-works/575.

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18

Boulanger, Karen Therese. „Factors related to satisfaction, pain and affect outcomes in massage therapy clients“. Thesis, The University of Iowa, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=3711080.

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Massage therapy is often used to treat musculoskeletal symptoms and to promote wellness. While evidence regarding its effectiveness is increasing, research related to actual practice and studies seeking to understand the mechanisms of massage therapy are needed. The purpose of this research was to describe the characteristics of massage therapists and their clients and to understand the role of communication in massage therapy outcomes. The first study examined the outcome expectations, expectancies, and behaviors of a random sample of massage therapists in Iowa (n=151) using a cross-sectional survey. The second study used a practice-based research design incorporating two samples of massage therapy clients (n=320 and n=321) to develop and validate a measure of client expectations of massage, the Client Expectations of Massage Scale (CEMS). The third study examined the influence of client expectations and massage therapists' interpersonal attractiveness on pain and satisfaction following massage. Social Cognitive Theory and Expectancy Violation Theory were used as frameworks to demonstrate how health behavior and communication theories can provide insight to massage therapy research. Results indicated that massage therapists had high expectations regarding the benefits of massage therapy and engaged in a variety of behaviors that reflect the clinical, educational, and interpersonal nature of massage therapy. In addition to using a variety of manual therapies, the massage therapists educated their clients in areas such as diet, stress management, and exercise to improve client health. Similarly, clients had positive expectations as measured by the outcome, clinical, educational, and interpersonal subscales of the CEMS. Positive outcome expectations predicted significant improvements in pain and serenity. High interpersonal expectations were related to negative changes in serenity. The third study revealed that high satisfaction was influenced by positive interpersonal attractiveness but more research is needed to understand the influence of client expectations being met on satisfaction. Initially high educational expectations, exceeded educational expectations, violated interpersonal expectations, and positive interpersonal attractiveness were related to less pain following massage. In conclusion, this research demonstrated that client expectations and massage therapist interpersonal attractiveness are important constructs to consider when evaluating the effects of massage therapy.

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Brown, Andrew Dickson. „Identification and analysis of alternative aberrant forms of the transcription factor ATF1“. Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244185.

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20

Battestella-Williams, Jaime Lyn. „An Exploration of the Experiences of Equine Therapy Specialists“. ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/7460.

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Horses have been an integral part of human history and progress for centuries. Horses and humans have united in diverse ways, including farming, war, construction, racing, and other areas of sports. Researchers have indicated that the use of horses for mental health and wellness is a growing trend that continues to lack strong, empirical evidence. Currently, there is limited research available on the experiences of certified equine specialists incorporating horses into mental health and wellness. It is essential to gain further insight into the incorporation of horses into psychology and counseling for therapists, as well as potential clients, interested in this form of alternative therapy. In this qualitative study, constructivism and phenomenology were used to explore the experiences of therapists using horses in therapy for mental health treatment and wellness. Purposeful sampling was used to recruit 8 therapists for semistructured interviews to gain an understanding of this phenomenon. Data analysis for this study was conducted through a phenomenological approach, thematic analysis, and a priori and emergent coding to identify 8 themes, activities, goals, and outcomes in using horses for mental health treatment and wellness, and insight into the use of horses for mental health and wellness. According to the American Horse Council, there are thousands of unwanted horses in the United States. Incorporating horses into psychology and counseling decreases the number of unwanted horses, as well as horse slaughter. Bringing horses and humans together promotes positive social change by giving both people and horses and new purpose.
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21

Denobrega, Renee Ann. „Evidence-Based Alternative Therapy to Reduce Anxiety in Ambulatory Mental Health Patients“. ScholarWorks, 2016. https://scholarworks.waldenu.edu/dissertations/1965.

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Evidence-Based Alternative Therapy to Reduce Anxiety in Ambulatory Mental Health Patients by Renee Denobrega MS, Widener University, 2013 BS, Alvernia University, 2007 Project Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Nursing Practice Walden University January 2016
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22

Williams, Duane A., Courtney D. Hall, Patsy Cantor, Jennifer Williams, N. Brown, Ryan Dulling und Ogechi Egbujor. „Reliability of Two Alternative Methods for the Standard Mid-thigh Isometric Pull“. Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etsu-works/573.

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The purpose of this study was to determine the reliability of two new alternative portable methods for measuring maximal isometric force measures while performing the standard mid-thigh pull. One method, the bar grip method, required the use of the trunk and upper extremity muscles, while the second method, the pelvic belt method, did not. Both methods demonstrated good test-retest reliability via randomized repeated measures over 24-36 hours. Interestingly, the pelvic belt method generally demonstrated average maximal forces up to 65% higher than the bar method. There was a good relationship between both methods. These new alternative methods could provide strength coaches an option for a more efficient, cost-effective, portable means for the mid-thigh pull test.
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Gotthold, Gunilla. „Alternativa behandlingsmetoder för kvinnor med tidiga klimakteriebesvär.En litteraturstudie“. Thesis, Högskolan i Gävle, Akademin för hälsa och arbetsliv, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-7661.

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Syftet med denna studie var att kartlägga alternativa behandlingsmetoder för behandling av tidiga klimakteriebesvär, kring menopaus. Studien genomfördes som en litteraturstudie med beskrivande design, där tjugo vetenskapliga artiklar granskades. Resultatet visar fem alternativa behandlingsmetoder: akupunktur, yoga, fysisk aktivitet, naturläkemedel och fytoöstrogener. Både akupunktur och yoga gav en signifikant förbättring vad det gäller värmevallningar, nattliga svettningar, sömnkvalitet och livskvalitet. Med ökad fysisk aktivitet upplevde kvinnorna färre fysiska och psykiska besvär kopplade till klimakteriet och förbättring av allmänna välbefinnandet, ingen skillnad sågs vad det gäller vasomotorbesvär. När naturläkemedel och fytoöstrogener jämförts med placebo, ses möjligen en minskning av värmevallningar och nattliga svettningar, samt ökning av livskvaliteten med dessa olika preparat men samma förbättring ses i dessa studier även med placebopreparat. Ingen av de alternativa behandlingsmetoderna hade effekt på vaginalslemhinnan och förbättrade därmed inte de urogenitala besvären. Slutsats av denna litteraturgenomgång av alternativa behandlingsmetoder är att vissa behandlingsmetoder innebär en förbättring vad det gäller tidiga klimakteriebesvär och livskvalitet, men att flera behandlingsmetoder inte är mer effektfulla än placebo. Ytterligare forskning, med fler stora randomiserade kontrollerade studier är nödvändig för att se effekten av och utvärdera de för närvarande tillängliga alternativa behandlingsmetoderna. Ännu ett forskningsområde är att studera kvinnornas upplevelser av alternativa behandlingsmetoder.
The aim of this study was to describe complementary therapies for treating early climacteric complaints, around menopause. The study was conducted as a literature review with a descriptive design, where the author examined twenty scientific articles. The result shows five complementary therapies, acupuncture, yoga, physical activity, herbal medicines and phytoestrogens. Both acupuncture and yoga significantly reduced hot flushes and night sweats, they also improved subjective sleep quality and quality of life. Increased physical activity made women report fewer physical and psychological symptoms attributed to menopause and improved general well-being, but it had no effect on vasomotor symptoms. When herbal medicines and phytoestrogens have been compared with placebo, they all showed a similar small relief of hot flushes and night sweats and improvement in quality of life. None of the complementary therapies showed effect on vaginal tracts and did not improve urogenital symptoms. The conclusion from this literature review is that some complementary therapies show improvement in the early menopausal symptoms and quality of life, but some treatments are not more powerful than placebo. Further research, with larger randomized controlled studies are necessary, both to see the effect of the currently accessible alternative treatments, but also to examine how women perceive the impact.
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Gothhold, Gunilla. „Alternativa behandlingsmetoder för kvinnor med tidiga klimakteriebesvär.En litteraturstudie“. Thesis, University of Gävle, Faculty of Health and Occupational Studies, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-7661.

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Syftet med denna studie var att kartlägga alternativa behandlingsmetoder för behandling av tidiga klimakteriebesvär, kring menopaus. Studien genomfördes som en litteraturstudie med beskrivande design, där tjugo vetenskapliga artiklar granskades. Resultatet visar fem alternativa behandlingsmetoder: akupunktur, yoga, fysisk aktivitet, naturläkemedel och fytoöstrogener. Både akupunktur och yoga gav en signifikant förbättring vad det gäller värmevallningar, nattliga svettningar, sömnkvalitet och livskvalitet. Med ökad fysisk aktivitet upplevde kvinnorna färre fysiska och psykiska besvär kopplade till klimakteriet och förbättring av allmänna välbefinnandet, ingen skillnad sågs vad det gäller vasomotorbesvär. När naturläkemedel och fytoöstrogener jämförts med placebo, ses möjligen en minskning av värmevallningar och nattliga svettningar, samt ökning av livskvaliteten med dessa olika preparat men samma förbättring ses i dessa studier även med placebopreparat. Ingen av de alternativa behandlingsmetoderna hade effekt på vaginalslemhinnan och förbättrade därmed inte de urogenitala besvären. Slutsats av denna litteraturgenomgång av alternativa behandlingsmetoder är att vissa behandlingsmetoder innebär en förbättring vad det gäller tidiga klimakteriebesvär och livskvalitet, men att flera behandlingsmetoder inte är mer effektfulla än placebo. Ytterligare forskning, med fler stora randomiserade kontrollerade studier är nödvändig för att se effekten av och utvärdera de för närvarande tillängliga alternativa behandlingsmetoderna. Ännu ett forskningsområde är att studera kvinnornas upplevelser av alternativa behandlingsmetoder.


The aim of this study was to describe complementary therapies for treating early climacteric complaints, around menopause. The study was conducted as a literature review with a descriptive design, where the author examined twenty scientific articles. The result shows five complementary therapies, acupuncture, yoga, physical activity, herbal medicines and phytoestrogens. Both acupuncture and yoga significantly reduced hot flushes and night sweats, they also improved subjective sleep quality and quality of life. Increased physical activity made women report fewer physical and psychological symptoms attributed to menopause and improved general well-being, but it had no effect on vasomotor symptoms. When herbal medicines and phytoestrogens have been compared with placebo, they all showed a similar small relief of hot flushes and night sweats and improvement in quality of life. None of the complementary therapies showed effect on vaginal tracts and did not improve urogenital symptoms. The conclusion from this literature review is that some complementary therapies show improvement in the early menopausal symptoms and quality of life, but some treatments are not more powerful than placebo. Further research, with larger randomized controlled studies are necessary, both to see the effect of the currently accessible alternative treatments, but also to examine how women perceive the impact.

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Bukhari, Mamdouh. „In vitro-studies relating to honey as an alternative approach to wound therapy“. Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/6669/.

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A comparative study was made between Manuka honey-the main honey used as an antibacterial agent in medicine and some commercially available honeys. Among 22 types of honey, five types were found to be the most effective and these are Rainforest +30, Manuka +20, Nigella sativa, Oak and New Zealand Rewarewa. Three types of honey showed negative response to Catalase (an enzyme which breaks hydrogen peroxide), namely New Zealand Rewarewa, Manuka +20 and Rainforest +30. Exposure of honey to autoclaving generally leads to a reduction in its antibacterial activity. This suggests that hydrogen peroxide and other antibacterial factors are removed/denatured by autoclaving, but that in the case of Manuka against S. aureus and Rain forest+30 against Ps. aeruginosa, some; unknown, non-destroyed, antibacterial factor remains. The antibacterial effects of honey on Fusobacterium nucleatum (an anaerobic bacterium which is a major cause of mouth abscesses) were studied. Undiluted Manuka honey was again shown to be the most effective antibacterial honey against this pathogen. Three types of bacteria were isolated from honey as contaminants. These were identified using 16SrRNA as: Lysinibacillus fusiformis, Staphylococcus epidermidis and Sporosarcina koreensis; and were respectively isolated from Oak honey, Nigella sativa honey and Manuka honey. Some commercial products containing Manuka honey were tested for their antibacterial efficacy. With the exception of the Manuka Honey Conditioner, all of the products showed antibacterial activity against S. aureus such as Body wash, Shampoo, Manuka oil, Kanuka oil, Manuka Body Wash, bee venom with Manuka honey and Vita Complex. Similar results were obtained when Ps. aeruginosa tested. However, in all cases, the antibacterial effect on both bacteria was more pronounced against S. aureus than it was against Ps. aeruginosa. The antibacterial effect of the three mouth-cleaning products was then tested against some bacterial mouth flora. The Manuka and Aquafresh tooth paste showed inhibition zones for all three bacteria, while the non-honey mouthwash had no effect on bacterial growth. Four types of honey were diluted from 80% to 5% to determine the minimum biofilm eradication concentration (MBEC). At a concentration of 20% all honeys killed both types of biofilm bacteria. Some pathogenic traits such as pyocyanin production and biofilm formation were found to be influenced by a range of honeys. Various wound dressings and wound treatments were tested for their antibacterial activity against planktonic and biofilm of S. aureus and Ps. aeruginosa. Panaderm, a mixture of antibiotics, was the most effective treatment against S. aureus and Ps. aeruginosa. Activon Manuka exhibited marked activity against S. aureus and moderate activity against Ps. aeruginosa. Flamazine showed moderate action against S. aureus and Ps. aeruginosa. The proprietary (non-honey based) hand gel showed weak action on both types of bacteria.
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De, Vries Chrissie. „Narratives of a family living with HIV/AIDS and a researcher's alternative story /“. Thesis, Link to the online version, 2004. http://hdl.handle.net/10019/1798.

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Snyder, Caroline Elizabeth. „Increasing Children's Interest in Augmentative and Alternative Communication Apps for iPad“. Ohio University Honors Tutorial College / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1399459343.

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Souza, Márcia Ebling de. „ATIVIDADE ANTIMICROBIANA E ANTIBIOFILME DE NANOPARTÍCULAS DE ÓLEO DE Melaleuca alternifolia“. Universidade Franciscana, 2014. http://tede.universidadefranciscana.edu.br:8080/handle/UFN-BDTD/217.

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Made available in DSpace on 2018-06-27T18:56:26Z (GMT). No. of bitstreams: 3 Marcia Ebling de Souza.pdf: 2695265 bytes, checksum: a2e937aea21007fe96d911a8926690fc (MD5) Marcia Ebling de Souza.pdf.txt: 137369 bytes, checksum: 1823ab125cb3d2d640b4054a50610fcf (MD5) Marcia Ebling de Souza.pdf.jpg: 3457 bytes, checksum: 86b6a5529e61dfd18d87fbf869cbc570 (MD5) Previous issue date: 2014-08-21
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Infections caused by Candida species are an important cause of morbidity and mortality in immunocompromised patients. This growing trend has been linked to resistance to antimicrobial therapy and the ability of the organism to form biofilms. Melaleuca alternifolia oil is traditionally used as an herbal antimicrobial that shows activity in biofilms formed by Candida species. The present study aimed to evaluate the antimicrobial and antibiofilm activity nanoparticles and the essential oil of M. alternifolia. Oil and characterization of nanoparticles M. alternifolia. Antimicrobial activity was determined by the microdilution technique was performed. The ability to form biofilms at different glucose concentrations and measured the levels of exopolysaccharides and proteins in the biofilms was verified. The qualitative analysis of biofilms was performed by staining of Calcofluor White. The cytotoxicity of nanoparticles and the oil was assessed. The chromatographic profile showed that M. alternifolia oil conforms with ISO 4730 with the main constituents, 41.9% of Terpinen-4-ol, 20.1% of γ-terpinene, 9.8% of α-terpinene and 6.0% of 1.8-Cineol. Nanoparticles M. alternifolia oil had a pH of 6.3, particle diameter of 158.2 ± 2 nm, polydispersity 0.213 ± 0.017 and zeta potential of -8.69 ± 0.80 mV. The oil and nanoparticles M. alternifolia showed antimicrobial activity against most microorganisms evaluated. Microorganisms that showed an increased capacity to form biofilms were C. albicans, C. tropicalis, C. membranafaciens, C. parapsilosis and C. glabrata at a concentration of 1% glucose. Administration of oil or nanoparticles of M. alternifolia oil represented a significant reduction of biofilm formed by all Candida species used, as well as a reduction in protein levels and exopolysaccharide biofilms. Was possible to visualize the reduction of biofilm in the presence of nanoparticles of M. alternifolia with Calcofluor White staining. The oil and nanoparticles M. alternifolia showed cytotoxic character at all concentrations evaluated. With the increase in the concentration of fetal calf serum medium, an inhibition of the toxic effect of the nanoparticles occurs. There are probably involved in protein-corona effect on the cytotoxicity of nanoparticles
As infecções causadas por espécies de Candida são importante causa de morbi-mortalidade em pacientes imunodeprimidos. Esta tendência crescente tem sido associada a resistência a terapia antimicrobiana e a capacidade do microrganismo em formar biofilmes. O óleo de Melaleuca alternifolia é um fitoterápico tradicionalmente utilizado como antimicrobiano, que apresenta atividade em biofilmes formados por espécies de Candida. O presente estudo teve como objetivo avaliar a atividade antimicrobiana e antibiofilme de nanopartículas e do óleo essencial de M. alternifolia. Foi realizada a caracterização do óleo e das nanopartículas de M. alternifólia A atividade antimicrobiana foi determinada através da técnica de microdiluição. Foi verificada a capacidade de formação de biofilmes em diferentes concentrações de glicose e mensurados os níveis de exopolissacarídeos e proteínas nos biofilmes formados. A análise qualitativa dos biofilmes foi realizada através da coloração de Calcoflúor Branco. Foi avaliada a citotoxicidade do óleo e das nanopartículas. O perfil cromatográfico demonstrou que óleo de M. alternifolia está de acordo com a ISO 4730 com os constituintes majoritários, 41,9% de Terpinen-4-ol, 20,1% de γ-Terpineno, 9,8% de α-Terpineno e 6,0% de 1,8-Cineol. As nanopartículas de óleo de M. alternifolia apresentaram pH de 6,3, diâmetro de partícula de 158,2 ± 2 nm, índice de polidispersão de 0,213 ± 0,017 e potencial zeta de -8,69 ± 0,80 mV. O óleo e as nanopartículas de M. alternifolia apresentaram atividade antimicrobiana frente a maioria dos microrganismos avalidados. Os microrganismos que apresentaram uma maior capacidade na formação de biofilmes foram C. albicans, C. tropicalis, C. membranafaciens, C. parapsilosis e C. glabrata na concentração de 1% de glicose. A administração de óleo ou as nanopartículas de óleo de M. alternifolia representou uma redução significativa do biofilme formado por todas as espécies de Candida utilizadas, bem como uma redução nos níveis de proteínas e exopolissacarídeos dos biofilmes. Foi possível visualizar a redução do biofilme na presença das nanopartículas de M. alternifolia com a coloração Calcofluor Branco. O óleo e as nanopartículas de M. alternifolia apresentaram caráter citotóxicos em todas as concentrações avaliadas. Com o aumento na concentração de soro fetal bovino do meio, ocorre uma inibição do efeito tóxico das nanopartículas. Provavelmente há o envolvimento do efeito proteína-corona na citotoxicidade das nanopartículas
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Miller, Elizabeth C. „Studies of nutritional support for prostate cancer prevention and therapy“. Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1124140836.

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Davis, Trent Alan. „Counseling and Complementary Therapy: A National Survey of Counselors' Experiences“. Diss., Virginia Tech, 2005. http://hdl.handle.net/10919/26964.

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There has been little research to date specifically addressing counselorsâ experiences with complementary therapy. The objective of this exploratory survey was to assess counselorsâ professional practice, knowledge and training, and personal experience with complementary therapy. The study design was a web-based, random sample survey of American Counseling Association members. Results indicated the typical respondent was female, Caucasian, holds a Masterâ s degree and works in a private practice/self-employed or community agency setting as an outpatient counselor. Few respondents asked about or had clients volunteer use of complementary therapy. Anxiety and depression were the most common client concerns for which respondents recommended or referred for complementary therapy. Respondents agreed that client referrals should be to licensed or certified practitioners. Respondents reported that complementary therapy provided clients with at least some positive benefits and few negative consequences. The majority of respondents included complementary therapy in counseling during the past year and thought that complementary therapy should be included in addition to counseling. Although respondents considered themselves qualified to discuss a variety of complementary therapies, few possessed licensure or certification. The majority of respondents used informal, self-study to gain knowledge of complementary therapy. Most respondents have personally experienced at least one complementary therapy, primarily â To improve overall wellnessâ . Respondents reported they received some to large benefits from this experience. A number of respondents descriptors had moderately positive associations with client usage, recommendation and referral, inclusion, and knowledge factors. These descriptors were those respondents who worked in a private practice/self-employed setting, as an outpatient counselor, were licensed as an LPC, provided individual, family/couples, or alcohol/substance abuse counseling, and had a psychodynamic orientation. There were moderately negative associations between respondents who worked in a K-12 setting, did not possess mental health licensure and were a Masterâ s student and client usage, recommendation and referral, and inclusion factors. The data provide support for the idea that counselors are beginning to embrace a post-modern approach, which gives consideration to complementary therapy interventions. However, the findings also suggested that the counseling profession still has a good deal of work to do before it can be considered truly holistic.
Ph. D.
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Romani, Karen. „Effectiveness of Yoga Therapy on Pain and Related Depression, Anxiety, Perceived Stress, and Quality of Life“. ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/7837.

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Individuals are becoming more dependent on medication for conditions such as chronic-pain, anxiety, and depression. It is reported that patients are often overprescribed medication while health outcomes do not improve. The medicalization of society is distracting attention from the possibility of other therapies such as complementary or alternative medicine (CAMs) that can improve health outcomes if they were as supported as pharmacological research and better received by the medical community. Yoga and meditation, the components of Mindfulness Based Stress Reduction (MBSR) and yoga therapy, have been shown as effective CAMs for cases of anxiety and depression related to chronic illness or chronic pain. There is little agreement in research, among yoga practitioners, and in the medical community on how to prescribe the delivery of yoga therapy interventions to reduce pain, depression, or anxiety. The purpose of this quantitative study and, to address this gap in the literature, is to provide the medical community protocols for the delivery of yoga therapy and to discover a “dose response” for yoga therapy among 6 individuals suffering pain and related affective disorders such as anxiety and depression. The findings of this study showed no significant difference among individuals who practice yoga therapy at the rate of one or three times per week on reported levels of depression, anxiety, pain, perceived stress or quality of life depending on the rate of practice. This study could impact the over-prescription of medication and reduce the dependence on psychopharmacology for management of affective disorders
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Ekström, Malin, und Annelie Ohlsson. „Alternativ och kompletterande kommunikation (AKK) för personer med autism“. Thesis, Örebro University, School of Health and Medical Sciences, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-10809.

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Syftet med denna studie var att beskriva effekten av alternativ och kompletterande kommunikation för personer med autism. Metoden som användes var en litteraturstudie där 11 vetenskapliga studier användes som underlag till resultatet. Resultatet visade att personer med autism bl.a. kan utveckla sin symbolförståelse, sitt spontana tal samt öka antalet ord vid användandet av alternativ och kompletterande kommunikation. Några av barnen visade även på en positiv utveckling av förmågan att generalisera sina kunskaper till andra situationer och kommunikationspartners.

Resultatet av denna litteraturstudie bör inte generaliseras till andra person än de som ingår i studierna då deltagarantalet är lågt och deltagarna befinner sig på ungefär samma kommunikationsnivå.

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Singer-MacNair, Kristy. „Challenges to Augmentative and Alternative Communication Interventions with Autism Spectrum Disorder Students“. Thesis, Walden University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10639718.

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Students with autism spectrum disorder (ASD) have challenges with communication, social interactions, and behavior, which can limit their functioning in school settings. They need to have functional communication skills to access the curriculum and have their needs met across all social environments. Special education teachers often experience barriers to successful implementation of augmentative and alternative communication (AAC) interventions appropriate for these students. The purpose of this case study was to understand how special education teachers experience AAC intervention processes, and illuminate the conditions for effective AAC implementation. A qualitative case study was conducted using interviews from 6 credentialed special education teachers who worked with ASD students for a minimum of 2 years in a school district in a western state. Coding and thematic analysis of data from interviews and work journals was conducted using Ely’s condition of change theory as a framework. Findings for teachers’ perspectives of conditions needed to successfully implement an AAC intervention reflected the need for more time, resources, knowledge and skills, and investment from stakeholders. Recommendations included provision of resources to special education teachers for autism specific materials, on-going autism specific training and assistance, additional time for preparation and related duties necessary for working with these students. Future research on overall strengthening of AAC interventions and overcoming challenges for change is needed. Results of this study might assist schools in empowering ASD students by facilitating their functional communication skills, involvement, learning and academic opportunities across social environments.

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Chauveau, Aurélie. „Identification des mutations à visée diagnostique et pronostique dans les néoplasies myéloprolifératives et impact sur l'épissage alternatif Sequential analysis of 18 genes in polycythemia vera and essential thrombocythemia reveals an association between mutational status and clinical outcome, in Genes chromosomes & cancer 56(5), May 2017 Benefits and pitfalls of pegylated interferon-α2a therapy in patients with myeloproliferative neoplasm-associated myelofibrosis: a French Intergroup of Myeloproliferative neoplasms (FIM) study, in Haematologica 103, March 2018“. Thesis, Brest, 2019. http://www.theses.fr/2019BRES0042.

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Les néoplasies myéloprolifératives (NMP), non BCR-ABL1, regroupent principalement la polyglobulie de Vaquez (PV), la thrombocytémie essentielle (TE) et la myélofibrose primitive (MFP).Ces pathologies partagent, dans des proportions variables, une mutation commune, la mutation JAK2 V617F. La protéine JAK2 mutée a une activité tyrosine kinase constitutive, impliquée dans le développement de la maladie. Cette mutation, seule, n’explique pas l’hétérogénéité phénotypique au sein des NMP. L’avènement des techniques de séquençage haut débit a permis de mieux appréhender la physiopathologie. Notre travail avait pour objectif l’identification de mutations additionnelles au sein de deux cohortes suivies au long cours en lien avec un risque d’aggravation de la maladie, l’une regroupant des patients en phase chronique (TE et PV JAK2 V617F), la seconde regroupant des patients avec une myélofibrose traitée par interféron. A l’instar d’autres travaux récents, nous avons montré que le nombre de mutations et la présence de mutations additionnelles sont associés à l’évolution de la maladie, voire à la réponse au traitement.Parmi les mutations identifiées, certaines pourraient influencer l’épissage. La deuxième partie de ce travail a donc consisté à étudier l’épissage alternatif en fonction des mutations présentes, et en particulier la mutation JAK2 (V617F) et de manière globale dans les TE. Un saut de l’exon 14 de JAK2 a été décrit chez des patients NMP présentant, ou non, la mutation JAK2 V617F. Cette mutation du gène JAK2 est prédite pour altérer un site de fixation de la protéine SRSF6 régulatrice de l’épissage. Nous observons que le saut de l’exon 14 est un événement peu fréquent chez les patients, modulé en partie par l’expression des protéines SR. L’analyse transcriptomique montre une grande hétérogénéité entre les patients en termes d’expression et d’épissage, ce qui ne nous a pas permis de mettre en évidence de profil caractéristique. Ces résultats soulignent l’importance de l’identification des mutations additionnelles au diagnostic et au cours du suivi.Nous avons pu, en outre, identifier quelques transcrits alternatifs associés à la présence de ces mutations. Le rôle fonctionnel de ces variants reste à définir
Polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF) are a group of Philadelphia-negative myeloproliferative neoplasm (MPN). These diseases share a common mutation, JAK2 V617F, in varying proportions. The mutated JAK2 protein has a constitutive tyrosine kinase activity, implicated in the physiopathology of MPN. This mutation alone does not explain the phenotypic heterogeneity within MPN.High throughput sequencing techniques helped understanding the physiopathology. This work aimed to identify additional mutations in two patient cohorts related to the aggravation risk of the disease. The first one consisted of patients in chronic phase (JAK2 V617F ET and PV), the second consisted in patients with myelofibrosis treated with interferon. Like other studies, we have shown that the number of mutations and the presence of additional mutations are associated with disease progression or with response to treatment. Some identified mutations could influence splicing. The second part of this work aimed at studying the putative impact of the JAK2 V617F mutation, on alternative splicing (AS).We also analyzed global AS profiles in ET. JAK2 exon 14 skipping has been described in NMP patients with or without the JAK2 V617F mutation.This mutation was predicted to alter the binding site of the SRSF6 splice-regulating protein. We observed that exon 14 skipping was an uncommon event in patients, in part related to SR protein expression. In addition, our transcriptomic-wide analysis showed a great heterogeneity between the patients with respect to both gene expression and splicing. This prevented us from identifying any characteristic profile. These results underscore the importance of identifying additional mutations at diagnosis and during follow-up. We have also been able to uncover some alternative transcripts associated with the presence of these mutations.The functional role of these variants remains to be defined
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Oklan, Ari M. „Reauthoring Narratives with Alternative Education Students Using Recorded Music Expressive Arts“. Thesis, Alliant International University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10278105.

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Alternative education students face many interacting challenges that put them at significant risk of dropping out of school (Carver & Lewis, 2010), as well as deleterious health and psychological outcomes, and intergenerational cycles of sociopolitical disadvantage (Laird, Kienzel, Debell & Chapman, 2007). Despite the persistent national epidemic of school dropout, few studies have investigated treatments for alternative education students, often characterized as “difficult to reach” given the chronic substance abuse, low motivation, and poor attendance typical of this population (Rumberger & Lim, 2008).

This study investigated the effectiveness of a novel music therapy intervention, Recorded Music Expressive Arts (RMEA), with alternative education students. The purpose of RMEA in this context was to engage students in a potentially motivating, culturally relevant treatment that satisfies identified provisions to ameliorate dropout (Kim & Taylor, 2008). RMEA employs narrative therapy concepts as a framework for treatment, and integrates songwriting, music production, and recording into psychotherapy. Through the song-creation process, participants were encouraged to “tell their story” to re-author problem-saturated personal narratives and discover more self-affirming ways of being (White & Epston, 1990).

Participants were 10 adolescent boys, age 14–18, attending an alternative education school in the San Francisco Bay Area. Ten 60-minute individual RMEA sessions were delivered twice weekly over 7–19 weeks. Pre/post data was analyzed using Vargha-Delaney’s A. Large effect sizes were found for a) coping (problem focused engagement, cognitive restructuring, problem solving, and emotional expression); b) substance misuse (decreased marijuana use) and co-occurring psychological disturbances (decreased school and behavior problems); c) increased contemplation and action readiness to respond to intervention; d) behavior (decreased internalizing, behavior, learning problems, and suspension rates); and e) attendance (increased attendance for RMEA sessions and days on which RMEA was delivered). Overall, the results indicate that RMEA is a viable and effective treatment for alternative education high school students. Analysis of participant interviews and song content further support results, as well as RMEAs proposed therapeutic mechanisms of action, including narrative therapy concepts. Findings highlight the need for replication studies with larger sample sizes, inclusion of adolescent girls, and other alternative education school settings.

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Taylor, Leah Ferree. „Well-Being through Live Music| A Heuristic Exploration“. Thesis, Saybrook University, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10929749.

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Live music is a popular activity that many adults attend regularly. Qualitative research on live music from a listener’s perspective and the meaning it brings to individuals’ lives is lacking. The purpose of this heuristic inquiry was to investigate the lived experience of attending live-music events from the perspective of adult concert-goers between the ages of 18 and 65 years. This phenomenon was explored through the primary research question, “What is the experience of attending live-music events?”

Eight co-researchers were selected to participate via a convenience sample recruitment strategy. Data was collected via open-ended interviews and analyzed through stages following the qualitative method of heuristic inquiry (Moustaskas, 1990).

Three main themes were found to be the core essence of the live music experience: (a) live music connects people deeply; (b) live music is a full body experience; and (c) live music can be transcendent. An increased energy or vitality was evident before, during, and after the live-music events. Co-researchers used these repeated experiences to release, renew, and recharge the positive emotions, and mental resources that they would in turn bring back to their everyday lives.

Findings from this research suggest that listening to live music is a mind-body-spirit practice that can be used by individuals to connect deeply to themselves, others, and something greater than what they know. As an inherently pleasurable activity, live music influenced people’s ability to be open-minded and appreciative for what they have in life. The experience positively impacted the participants physically, mentally, emotionally, and spiritually, which may have implications on overall well-being.

This is the first qualitative study that demonstrated ways in which people can participate in live-music events as a method of self-care to enhance their sense of well-being through meaningful connections, mind-body awareness, and transcendent experiences. Future research studies should examine the effects of live music on overall health outcomes and components of well-being. Keywords: live music, well-being, transcendence, appreciation, mind-body-spirit practice

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Sobie, Timothy J. „Body schema acuity training and Feldenkrais? movements compared to core stabilization biofeedback and motor control exercises| Comparative effects on chronic non-specific low back pain in an outpatient clinical setting| A randomized controlled comparative efficacy study“. Thesis, Saybrook University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10251703.

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Back problems continue to be a leading cause for disability in all of medicine and are the number one symptom disorder for consulting integrative medicine practitioners. Feldenkrais® practitioners aim to clarify new functional interrelationships towards an improved neuroplasticity-based change in the cognitive construct of one’s own background body schema. These phenomena have been found to clinically correlate to chronic pain through concurrent distortions in the reorganization of usual sensory-motor cortical representations in the brain – being further associated with altered body perception (Wand, et al. 2016). The Feldenkrais Method ® (FM) is a comprehensive approach being manifested through manual sensory contact (FI®) techniques and movement experiences (ATM®) and has been anecdotally purported to improve symptoms and functions in Chronic Non-specific Low Back Pain (CNSLBP). However, there is little scientific evidence to support superior treatment efficacy.

A Randomized Controlled Trial compared a novel Virtual Reality Bones™ / Feldenkrais® Movement (VRB3/FM) intervention against more conventional protocols for Core Stabilization Biofeedback / Motor Control Exercises (CSB/MCE). The (VRB 3)™ treatment component consisted of full-scale skeletal models, kinematic avatars, skeletal density imagery, temporal bone-vestibular system relationships, and haptic self-touch techniques being aimed to re-conceptualize participant’s prior notions and beliefs regarding body schema and low back pain (LBP). N=30 participating patients with CNSLBP were assigned to either the experimental group (VRB3/FM @ N=15) or the control group (CSB/MCE @ N=15). Known confounding biopsychosocial variables were controlled via stratified-random assignment on the FABQ. Treatment Outcome measures included VAS-PAIN, RMDQ, PSFS, and Timed Position Endurances Tests – including Flexion / Extension Ratios at baseline, 2-weeks, 4-weeks and 8-weeks. Statistical Analysis was conducted using Wilcoxon Rank Sum and paired, two-tailed t-test. Results showed that the VRB3/FM group demonstrated greater improvement in all treatment outcome measures as compared to the matched CSB/MCE control group.

This is the first RCT study to demonstrate that a Feldenkrais Method® based approach being combined with Virtual Reality Bones™ can be more efficacious for the treatment of CNSLBP than the current and accepted physical medicine standard of isolated Core Stabilization Biofeedback / Training and Motor Control Exercises. Future multi-site RCT studies with larger sample sizes are therefore recommended.

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Al, Mutairi Fouad. „Alternative methods of treating atelectasis in post-operative patients“. Thesis, University of Chester, 2013. http://hdl.handle.net/10034/311066.

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Cardiac surgery incisional pain can decrease inspiratory effort, alter normal respiratory mechanics, and increase the potential for post-operative pulmonary complications. Post-surgical atelectasis is the most frequent complication after coronary artery bypass grafting (CABG), ranging from 54% to 92%. All types of therapy such as an incentive spirometry (IS), deep breathing exercises (DBE) or continuous positive airway pressure (CPAP) have a valuable role to play in the prevention or the treatment of post-surgical atelectasis. However, the type of therapy that should be used is not completely clear yet. The present research aims to evaluate the benefit of early use of CPAP via mask therapy to treat or prevent post-surgical atelectasis after CABG, particularly in smokers and elderly patients, as compared to regular (IS) therapy. Also, it aims to evaluate the patients' and medical staff's experience about the use of the new method of CPAP via mask therapy. The present research was conducted at King Fahd Armed Forces Hospital in Saudi Arabia between March 2010 and December 2011. It used a mixed methods approach. The first two studies were intervention quantitative studies, which investigated the benefit of CPAP via mask therapy. The others were qualitative studies that evaluated the experience of patients and medical staff regarding CPAP therapy use.A total of 180 patients (male and female) (36 in each group) participated in the two quantitative studies. Ninety two participants (male and female) participated in the qualitative studies. The first quantitative study results showed an improvement in CPAP via mask therapy for half hours every two hours group measurements as compared to IS therapy groups. IC was increased significantly in the "CPAP every two hours group" as compared to control group (IS) (baseline mean for IS group 1.34L and "CPAP every two hours group" 1.42L, post- therapy mean 1.59L and 1.88L respectively, p= 0.037). In addition, when chest physiotherapy was added to the two regimens, the improvement of CPAP therapy measurements became more than IS therapy. Moreover, the patient’s acceptance rate for CPAP therapy every two hours was 93% and the medical staff acceptance rate was 86%. CPAP via mask therapy for half hour every two hours had better outcomes in treating or preventing post-surgical atelectasis after CABG, particularly in smokers and elderly patients. Adding chest physiotherapy led to even better outcomes. The use of the new method of CPAP therapy had high acceptance rate by the participants and medical staff.
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McKinney, Bridget L. „Therapist's Perceptions of Walk and Talk Therapy: A Grounded Study“. ScholarWorks@UNO, 2011. http://scholarworks.uno.edu/td/1375.

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Our society has become less physically active (U.S. Department of Health and Human Services, 2010) and less connected to nature than ever before (Berger & Mcleod, 2006). Spending leisure time indoors, technological advancements, urban living, and car dependent communities have led to these changes (Dustin, Bricker, & Schwab, 2010; Hansen-Ketchum, Marck, & Reutter, 2009; Norman & Mills, 2004). As a result, physical health and mental health is deteriorating (Dustin et al., 2010; Maller, Townsend, Pryor, Brown & Leger, 2005). Physical activity and nature can each produce mental and physical health benefits; some approaches such as adventure-based counseling and wilderness therapy already incorporate these elements. A promising alternative approach using physical activity and nature has received attention in recent years. Walk and talk therapy has been described as an intervention that combines counseling, walking, and the outdoors (Doucette, 2004). Despite, a small number of therapists using the approach (Gontang, 2009), anecdotal research (Hays, 1994), and a description of the approach (Doucette, 2004), little is known about walk and talk therapy. In this qualitative study 11 therapists were interviewed about their experiences with walk and talk therapy. Main themes of the study suggested characteristics, a procedure, reasons walk and talk therapy evolved, limitations, outcomes, and a framework for practice for walk and talk therapy. Therapists believe walk and talk therapy is beneficial for clients as well as therapists. Implications for therapists, researchers, and counselor educators are provided.
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Hollenberg, Daniel B. „Understanding plural medicine, alternative and biomedical therapy use among chronic illness sufferers. a Canadian study“. Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ35062.pdf.

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Kenyon, Janet. „Down-regulation of ColQ by RNA interference as a potential alternative therapy in myasthetic disorders“. Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.531967.

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Adamski, Vivian [Verfasser]. „Analysis of chemotherapeutic-induced tumor dormancy in Glioblastoma Multiforme and alternative therapy approaches / Vivian Adamski“. Kiel : Universitätsbibliothek Kiel, 2019. http://d-nb.info/1197612467/34.

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Druiff, Philippa. „Psychodynamic therapy with low-income women : the 'talking cure' as a desirable and alternative intervention“. Thesis, Stellenbosch : Stellenbosch University, 2001. http://hdl.handle.net/10019.1/52420.

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Thesis (MA)--University of Stellenbosch, 2001.
ENGLISH ABSTRACT: This study reviews the literature regarding psychodynamic therapy with low-income women. Low-income women are at psychological risk for developing emotional distress as a result of their deprived living circumstances. They have, however, received little attention from psychological research and practice. This literature review explores what psychological interventions are available for low-income women. It is found that psychodynamic therapy is largely unavailable to low-income women for a variety of reasons, which range from classism, sexism and ignorance to the cogent feminist and cross cultural critiques. It is argued that psychodynamic therapy should be more available to low-income women as it provides a sophisticated understanding of how oppressive social ideologies are internalized in the unconscious, thus facilitating, through therapy, a process of deconstruction and political subversion. Suggestions are also offered as to how to make psychodynamic therapy more accessible to low-income women.
AFRIKAANSE OPSOMMING: Hierdie studie bied 'n oorsig van die beskikbare literatuur aangaande psigodinamiese terapie vir laer inkomste vrouens. Die groep is tot 'n meerdere mate blootgestel aan die ontwikkeling van emosionele stress trauma weens hul ontneemde lewensomstandighede. Laer inkomste vrouens het tot hede min aandag geniet met betrekking tot psigologiese navorsing en praktyk. Hierdie literatuur oorsig fokus op gepaste psigologiese ingryping wat beskikbaar is vir die spesifieke groep. Die ontoeganklikheid van psigodinamiese terapie beskikbaar, vir laer inkomste vrouens, kan toegeskryf word aan 'n verskeidenheid faktore: die strek van klassisme, seksisme en onkunde tot oortuigende feministiese en kruis kulturele beoordeling en debat. Hierdie verhandeling stel voor dat psigodinamiese terapie meer beskikbar moet wees tot laer inkomste vrouens, want dit stel 'n gesofisikeerde begrip, ten doel van hoe onderdrukkende sosiale ideologie geinternaliseer word in die onderbewussyn en die teenwerking daarvan. Die geskrif beredeneer hoe terapie kan fasiliteer in die proses van de-konstruksie en politieke subversie. Dit word ook voorgestel hoe om psigodinamiese terapie toeganklik to maak vir laer inkomste vrouens.
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Birch, Maxine. „The quest for self-discovery : the reconstruction of self identity stories in alternative therapy groups“. Thesis, Oxford Brookes University, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363640.

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Gärtner, Vera. „Hälsoklanger : sökandet efter ljudens och musikens goda inverkan på människan“. Thesis, Kungl. Musikhögskolan, Institutionen för musik, pedagogik och samhälle, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kmh:diva-2499.

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Ljudens och musikens påverkan på människan har alltid intresserat mig i egenskap av violinbyggarmästare men också som cellopedagog. Forskningen inom detta område är starkt begränsad och rör till största delen terapeutiska metoder och då främst musikterapi. Dock använder sig musikterapeuter inte av utifrån kommande frekvenser i sitt arbete och de alternativa terapeuterna har inte vetenskapliga belägg för frekvensernas verkan. Syftet med studien har varit att utföra en grundforskning om hälsoklanger som kan inspirera till vidare forskning om hur utifrån tillförda ljud och musik påverkar människan samt exemplifiera hur några musikterapeuter och tomatiskonsulter i Sverige och Tyskland erbjuder musik och ljud som behandlings- eller träningsform. Studien genomfördes genom en kombination av kvantitativa och kvalitativa metoder: med en enkätundersökning, intervjuer samt personlig kommunikation med musikterapeuter och alternativa terapeuter, en stressforskare och två tomatiskonsulter. Resultaten tyder på att ljud och musik både kan ha stimulerande och lugnande inverkan på människan, men att en tillförlitlig vetenskaplig värderingsmetod saknas för dem som erbjuder behandlingar. En fortsatt forskning blir att vidare undersöka hur utifrån tillförda ljud och musik påverkar människan. Förutsättningen för att kunna mäta detta är att de valda ljud- eller musikavsnitten inte förekommer enbart punktuellt utan under en längre sammanhängande tidsperiod samt att tillgång finns till därför passande medicinsk mätutrustning och en undersökningsgrupp vars storlek utgår från ett antagande om hur stora effekter man kan förvänta sig på en viss definierad utfallsvariabel (2.7 Musikens påverkan på kropp och själ). Studien kan i bästa fall även ge inspiration till fortsatt forskning kring förbättring av negativa bullriga ljudmiljöer.
The effects of sound and music have always been of great interest to me, both as a Luthier, as a Cellist and Strings teacher. Research in this area is very limited and mainly confined to methods of therapy, in particular Music Therapy. Music Therapists, however, do not employ the use of different sound frequencies in their therapy and the effects of frequencies in other forms of alternative therapy have not yet been scientifically researched or validated. The object of this study has been to research how external sounds and music affect people, and to examine the means by which this is used in therapeutic contexts, such as in Music Therapy and Tomatis training. This research was conducted using quantitative and qualitative methods, through surveys, interviews and personal communication with Music Therapists, Alternative Therapists, Stress Researchers and two Tomatis Consultants. The research suggests that sound and music can have a stimulating as well as a soothing influence on people, but that a thorough scientifically based investigation into how external sounds and music affect people is needed for professionals in this field of work. Continued research in this area would involve using chosen external sounds or excerpts of music that are not only short impulses but of a longer duration, access to relevant medical equipment to measure the effects of these sounds and an appropriately sized group of research subjects to correlate with the expected effects of a defined research variable. (2.7 Musikens påverkan på kropp och själ) It is hoped that this study will provide a foundation for further research into the effects of frequencies, sound and music, also with a view to finding means to improve negative, disturbing sound environments.
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Maia, Marina Valente. „Avaliação dos efeitos adversos às drogas (minocilina, ofloxacina e clofazimina) do esquema alternativo para tratamento da hanseníase multibacilar“. Universidade Federal do Amazonas - Fundação Alfredo da Matta, 2012. http://tede.ufam.edu.br/handle/tede/3658.

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Made available in DSpace on 2015-04-22T22:14:14Z (GMT). No. of bitstreams: 1 Marina Valente Maia.pdf: 5078341 bytes, checksum: 01644b70bc08b473565219d3cfbca193 (MD5) Previous issue date: 2012-04-30
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
After introduction of multi-drug therapy (MDT/OMS) there were decline in prevalence coefficients and new cases detections, however, the records of drug resistance and relapse cases are threatening factors against lepra control, therefore, the importance of new alternative schemes and monitoring adverse effects, avoiding abandonment or irregularity to treatment. Objectives: Describe side-effects of multi-drug regimen containing minocycline, ofloxacin and clofazimine in multibacillary (MB) leprosy patients and analyse the clinicalbacteriologic indices. Materials and Methods: A prospective, descriptive and observational study, in multibacillary patients, including intolerance cases of standard MDT and relapse cases, carried out in Alfredo da Matta Foundation, Manaus, Amazonas, Brazil, during april 2010 and january 2012. The side-effects were recorded of every individual patient, filled during the course of alternative treatment. The patients received alternative therapy with daily self-administered doses of 100mg of minocycline, 400 mg of ofloxacin and 50mg of clofazimine and a month supervised dose of 300mg of clofazimine for 06 months, thereafter 18 months of daily self-administered doses of ofloxacin 400mg, clofazimine 50mg and month supervised dose of clofazimine 300mg. Results and Discussions: During research 26 patients were treated, however, of these, only 21 cases were included in this study. The mild and not persistent side-effects occurred in 33,3% of patients. From the 37 side-effects, 45,9% episodes was attributed to ofloxacin, such as abdominal pain, nausea, vomiting, headache and insomnia; 21,6% due to clofazimine, 100% of patients with skin pigmentation; however, no side-effets due to minocycline. Mean duration for the development of adverse effects from the start of therapy was 15,2 days. The media interval of follow-up was 13,7 months and 23,8% of patients completed the 24 months trerapy. All the patients tolerated the drugs well and the adhesion was satisfactory, among 15 patients that completed the first treatment year, 14 took 12 doses at 12 months from alternative regimen. Conclusion: The alternative therapy had a similar feasibility and operational mode from MB/MDT, with safe, well tolerated and good adhesion with no serious events. The side-effects attributed to alternative regimen were comparable to previous studies, however this new three drugs combination indicates the importance of these research results. No drug was stopped unlike others standard MDT studies which had treatment interruption by side-effects. There was significant correlation (p<0,001) between clinical classification and histopatologic diagnosis. At the end of first year, there was clinical improvement and bacteriologic index reduction. Nevertheless, it s necessary a follow-up and new inclusions to guarantee the efficacy and safe for the alternative regimen.
Após introdução do esquema poliquimioterápico padrão (PQT/OMS), houve declínio nos coeficientes de prevalência e detecção de casos novos, entretanto, os registros de resistência medicamentosa e casos de recidiva representam ameaça para o controle da hanseníase, por isso a importância da proposição de novos esquemas alternativos e a necessidade de monitorar seus efeitos adversos, evitando-se casos de abandono ou irregularidade ao tratamento. Objetivos: Descrever os efeitos adversos do esquema terapêutico alternativo, contendo a associação clofazimina, ofloxacina e minociclina, em pacientes com hanseníase multibacilar e análise da evolução clínico-baciloscópica dos pacientes. Materiais e Métodos: Estudo prospectivo, descritivo e observacional, de casos multibacilares, incluindo casos de recidiva da doença ou intolerância à poliquimioterapia padrão, realizado na Fundação Alfredo da Matta, Manaus, Amazonas, Brasil, no período de abril de 2010 e janeiro de 2012. Os efeitos adversos foram registrados em formulários individuais para cada paciente, preenchidos ao longo do tratamento. Os indivíduos receberam o esquema alternativo, composto de doses diárias auto-administradas de 100mg de minociclina, 400mg de ofloxacina e 50mg de clofazimina e dose mensal supervisionada de 300mg de clofazimina por seis meses, seguida de 18 meses de doses diárias autoadministradas de ofloxacina 400mg, clofazimina 50 mg e dose supervisionada mensal de clofazimina 300mg. Resultados: Durante o período foram selecionados 26 pacientes, dos quais 21 foram incluídos no estudo. Efeitos adversos leves e transitórios foram observados em 33,3% dos pacientes. Do total de 37 efeitos secundários, 45,9% foram atribuídos à ofloxacina, como dor abdominal, náuseas, vômitos, cefaléia e insônia; 21,6% associados à clofazimina, com relatos e observação em 100% dos pacientes de hiperpigmentação cutânea; entretanto, nenhum efeito foi relacionado à minociclina, especificamente. O tempo médio de desenvolvimento das reações adversas a partir do início do esquema foi de 15,2 dias. A duração média do acompanhamento dos pacientes foi de 13,7 meses, sendo que 23,8% dos pacientes já concluíram o tratamento em 24 meses. A adesão e regularidade ao esquema foram satisfatórias, dos 15 pacientes que já completaram o primeiro ano de tratamento, 14 indivíduos realizaram 12 doses do esquema proposto em 12 meses. Discussão/Conclusão: O esquema alternativo demonstrou viabilidade e operacionalização semelhantes ao esquema PQT/MB, com segurança, boa tolerabilidade e adesão dos pacientes. A porcentagem de efeitos adversos às drogas foi compatível a de outros trabalhos, contudo, a inovação na combinação das três drogas acima, demonstra a importância dos resultados desta pesquisa. Não houve registros de casos graves que indicassem à suspensão ou interrupção do tratamento. Houve correlação significativa (p<0,001) entre a classificação clínica e o diagnóstico histopatológico. Ao fim do primeiro ano do esquema alternativo, os pacientes apresentaram melhora clínica e redução do índice baciloscópico médio. Todavia, há necessidade de acompanhamento dos indivíduos e aumento do número amostral para garantir a eficácia e segurança ao tratamento em longo prazo.
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Finnie, Sara Elizabeth. „MUSIC THERAPISTS’ EXPERIENCES WITH CLIENTS WITH AUTISM SPECTRUM DISORDER WHO USE AUGMENTATIVE AND ALTERNATIVE COMMUNICATION“. UKnowledge, 2018. https://uknowledge.uky.edu/music_etds/127.

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Music therapists frequently work with clients with Autism Spectrum Disorder (ASD) who use Augmentative and Alternative Communication (AAC). The purpose of this study was to gather information on music therapists’ current experiences with AAC training as well as music therapists’ perceptions of their own communication abilities when communicating with clients who have ASD using their preferred AAC system. The researcher invited 7,279 board-certified music therapists to participate in this study via email, of which 366 completed the survey. Participants reported most often providing services to children and adolescents with ASD, and frequently using electronic AAC and electronic apps with their clients with ASD. The majority (71.2%) of participants stated that they would like additional training in the use of AAC. Of the music therapists who had participated in previous AAC training, many had received training at work or by an SLP or other certified professional. Results of this study provide information about the current practices and perceptions of board-certified music therapists working with clients with ASD.
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Heller, Kristin Noreen. „Alternative to Gene Replacement for Duchenne Muscular Dystrophy using Human Alpha7 Integrin (ITGA7)“. The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1388401639.

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Fetzer, Alice A.-Hui Osborn. „Exploring Korean Hand Therapy in Treating Plantar Fasciitis: A Pilot Study“. BYU ScholarsArchive, 2020. https://scholarsarchive.byu.edu/etd/9241.

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PF is one of the most common foot and ankle problems. People with PF experience mild to severe pain that interferes moderately with activities of daily living (ADL). Due to chronic pain that interferes with ADL, people with PF often use non-steroidal anti-inflammatory medications and/or acetaminophen. These medications alleviate pain but cannot eliminate it. Additionally, with chronic use, these medications can cause well-known adverse side effects. The purposes of this study were to investigate the effect of Korean Hand Therapy (KHT) in (1) treating the pain experienced in patients with plantar fasciitis (PF), (2) evaluating its impact on functionality, and (3) assessing participants' self-adherence to treatment. A pre-post mixed methods pilot study was conducted with 28 participants. Baseline measures included a demographic questionnaire, height and weight, a 10-point pain scale, the foot function index (FFI), and measurement of the plantar fascia via ultrasound. As a group, participants were taught about KHT and how to self-administer it. Participants then self-administered KHT for four weeks. Three weekly electronic surveys were sent asking participants about their pain and use of KHT. After four weeks, participants returned for final data collection, including a focus group. Baseline measures, except the demographic questionnaire and height and weight, were repeated. Thickness of PF was not correlated with pain at baseline (r = -0.14, p = 0.47). Compared to baseline, pain was significantly reduced after the initial KHT treatment on the first visit (4.875 vs 2.625, p < 0.00) and at the 4-week follow up (4.875 vs 2.528, p < 0.05). On average for all four weeks, participants reported 5.48 (SD 1.50) days of self-guided KHT per week. PF thickness was not significantly reduced at the follow up session at 4 weeks (t =1.16, p = 0.26). FFI scores were significantly improved between baseline and four weeks: Pain (t = 3.80, p < 0.00), Activity Limitation (t = 2.64, p = 0.02), and Disability (t = 4.74, p < 0.00) and overall FFI (t = 4.83, p < 0.00). Findings suggest KHT may reduce pain and increase functionality for people who experience PF. While the sample was small, KHT is low-risk, low-cost, and easily self-administered. Further investigation is needed on the long-term effects of KHT and its ability to generally alleviate all types of pain.
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Gang, Na-Hyun. „Action research: an exploration of a music therapy student's journey of establishing a therapeutic relationship with a child with autistic spectrum disorder in music therapy : a research dissertation presented in partial fulfilment of the requirements for the Master of Music Therapy at New Zealand School of Music, Wellington, New Zealand“. Massey University, 2009. http://hdl.handle.net/10179/1155.

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This action research project examines the researcher’s journey of establishing a therapeutic relationship with a child with autism spectrum disorder during her practicum. Children with ASD present difficulty in communication and social relationship skills. As a student in training with a limited experience, the researcher had uncertainty and low confidence with regard to her clinical and professional skills which affected her work. In this project, the researcher has examined her own process of music therapy with a child with ASD and shows how she was able to improve her practice and therefore establish meaningful and effective therapeutic relationships with this client population and obtain valuable learning through the training. The study was conducted at a dedicated therapy centre in New Zealand where the researcher was in placement. A total of seven, thirty-minute weekly individual music therapy sessions and four supervision sessions were employed. This process was adapted into the design of action cycles which involved the repeated process of planning, action and evaluation. In-depth analysis of the researcher’s work was carried out throughout the cycles, using clinical notes, journal excerpts, supervision notes and video recordings of the sessions. The findings suggest that the researcher was able to improve her practice while attempting to build a therapeutic relationship with the client. Various clinical and personal issues arose such as uncertainty about improvisation, and lack of confidence in professional skills including communicating with parents, which led to disjunction and burnout symptoms. Discussions in supervision aided in in-depth reflection of the researcher’s work as well as emotional support. The researcher could ultimately develop ‘internal supervisor’ and was able to use independent strategies to help develop her work. Implications for training include making personal therapy a compulsory course requirement, providing training on professional skills, and student support groups. Future research may investigate the effectiveness of verbal input in music therapy and the emotional stages of parents.
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