Thematische Bibliographien / Alkyl-quinolones

Inhaltsverzeichnis

  1. Zeitschriftenartikel
  2. Dissertationen
  3. Buchteile

Auswahl der wissenschaftlichen Literatur zum Thema „Alkyl-quinolones“

Autor: Grafiati
Veröffentlicht am 25. Mai 2024

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Zeitschriftenartikel zum Thema "Alkyl-quinolones"

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Liu, Huanhuan, Huadan Liu, Enhua Wang, Liangqun Li, Zhongsheng Luo, Jiafu Cao, Jialin Chen, Lishou Yang und Xiaosheng Yang. „Hydrogen Bond Assisted Three-Component Tandem Reactions to Access N-Alkyl-4-Quinolones“. Molecules 28, Nr. 5 (02.03.2023): 2304. http://dx.doi.org/10.3390/molecules28052304.

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Hydrogen-bonding catalytic reactions have gained great interest. Herein, a hydrogen-bond-assisted three-component tandem reaction for the efficient synthesis of N-alkyl-4-quinolones is described. This novel strategy features the first proof of polyphosphate ester (PPE) as a dual hydrogen-bonding catalyst and the use of readily available starting materials for the preparation of N-alkyl-4-quinolones. The method provides a diversity of N-alkyl-4-quinolones in moderate to good yields. The compound 4h demonstrated good neuroprotective activity against N-methyl-ᴅ-aspartate (NMDA)-induced excitotoxicity in PC12 cells.
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2

Mollova-Sapundzhieva, Yordanka, Plamen Angelov, Danail Georgiev und Pavel Yanev. „Synthetic approach to 2-alkyl-4-quinolones and 2-alkyl-4-quinolone-3-carboxamides based on common β-keto amide precursors“. Beilstein Journal of Organic Chemistry 19 (23.11.2023): 1804–10. http://dx.doi.org/10.3762/bjoc.19.132.

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β-Keto amides were used as convenient precursors to both 2-alkyl-4-quinolones and 2-alkyl-4-quinolone-3-carboxamides. The utility of this approach is demonstrated with the synthesis of fourteen novel and four known quinolone derivatives, including natural products of microbial origin such as HHQ and its C5-congener. Two compounds with high activity against S. aureus have been identified among the newly obtained quinolones, with MICs ≤ 3.12 and ≤ 6.25 µg/mL, respectively.
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Tang, Jing, und Xian Huang. „Convenient synthesis of 5-(Arylamino(Alkylthio)Methylene)-2,2-Dimethyl-1,3-Dioxane-4,6-Diones and 2-Arylthio-4-Quinolones“. Journal of Chemical Research 2003, Nr. 3 (März 2003): 140–41. http://dx.doi.org/10.3184/030823403103173264.

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Meldrum's acid reacted with an aryl isothiocynate and alkyl halides to afford the 5-(arylamino(alkylthio)methylene)-5-methylthio-2,2-dimethyl-1,3-dioxane-4,6-diones and the compounds underwent thermal cyclization to give the 4-2-arylthio-4(1 H)-quinolones
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Bezuglyi, P. A., I. V. Ukrainets, V. I. Treskach und A. V. Turov. „4-Hydroxy-2-quinolones. 1. Efficient method for obtaining 3-alkyl-4-hydroxy-2-quinolones“. Chemistry of Heterocyclic Compounds 27, Nr. 11 (November 1991): 1237–38. http://dx.doi.org/10.1007/bf00471752.

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5

Saalim, Muhammad, Jessica Villegas-Moreno und Benjamin R. Clark. „Bacterial Alkyl-4-quinolones: Discovery, Structural Diversity and Biological Properties“. Molecules 25, Nr. 23 (02.12.2020): 5689. http://dx.doi.org/10.3390/molecules25235689.

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The alkyl-4-quinolones (AQs) are a class of metabolites produced primarily by members of the Pseudomonas and Burkholderia genera, consisting of a 4-quinolone core substituted by a range of pendant groups, most commonly at the C-2 position. The history of this class of compounds dates back to the 1940s, when a range of alkylquinolones with notable antibiotic properties were first isolated from Pseudomonas aeruginosa. More recently, it was discovered that an alkylquinolone derivative, the Pseudomonas Quinolone Signal (PQS) plays a key role in bacterial communication and quorum sensing in Pseudomonas aeruginosa. Many of the best-studied examples contain simple hydrocarbon side-chains, but more recent studies have revealed a wide range of structurally diverse examples from multiple bacterial genera, including those with aromatic, isoprenoid, or sulfur-containing side-chains. In addition to their well-known antimicrobial properties, alkylquinolones have been reported with antimalarial, antifungal, antialgal, and antioxidant properties. Here we review the structural diversity and biological activity of these intriguing metabolites.
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Vrla, Geoffrey D., Mark Esposito, Chen Zhang, Yibin Kang, Mohammad R. Seyedsayamdost und Zemer Gitai. „Cytotoxic alkyl-quinolones mediate surface-induced virulence in Pseudomonas aeruginosa“. PLOS Pathogens 16, Nr. 9 (14.09.2020): e1008867. http://dx.doi.org/10.1371/journal.ppat.1008867.

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7

BEZUGLYI, P. A., I. V. UKRAINETS, V. I. TRESKATCH und A. V. TUROV. „ChemInform Abstract: 4-Hydroxy-2-quinolones. Part 1. Effective Preparation of 3-Alkyl-4- hydroxy-2-quinolones.“ ChemInform 24, Nr. 37 (20.08.2010): no. http://dx.doi.org/10.1002/chin.199337226.

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8

Chen, Bang-chi, Xian Huang und Jin Wang. „A Versatile Synthesis of 2-Alkyl and 2-Aryl 4-Quinolones“. Synthesis 1987, Nr. 05 (1987): 482–83. http://dx.doi.org/10.1055/s-1987-33427.

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9

Gupta, Rashmi, und Martin Schuster. „Quorum sensing modulates colony morphology through alkyl quinolones in Pseudomonas aeruginosa“. BMC Microbiology 12, Nr. 1 (2012): 30. http://dx.doi.org/10.1186/1471-2180-12-30.

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10

Michalet, S., P. M. Allard, C. Commun, V. T. Nguyen Ngoc, K. Nouwade, B. Gioia, M. G. Dijoux-Franca, J. L. Wolfender und A. Doléans-Jordheim. „ePS6.03 Alkyl-Quinolones derivatives could predict Pseudomonas infection chronicity in cystic fibrosis“. Journal of Cystic Fibrosis 19 (Juni 2020): S52—S53. http://dx.doi.org/10.1016/s1569-1993(20)30331-3.

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Dissertationen zum Thema "Alkyl-quinolones"

1

Fletcher, Matthew Paul. „Biosynthesis and Regulation of 2-Alkyl-4-Quinolones in Pseudomonas aeruginosa“. Thesis, University of Nottingham, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.489703.

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Pseudomonas aentginosa is an opportunistic pathogen that produces an extensive arsenal of virulence determinants which are regulated in a cell-density dependent manner via quorum-sensing (QS). P. aeruginosa contains two sets of hierarchicallyarranged QS systems, known as las and rhl, which utilise acyl-homoserine lactone (AHL)-based signalling molecules. Recently, a novel class ofQS signal molecule has been discovered in P. aeruginosa, known as 2-alkyl-4-quinolones (AQs), arguably the most important of which are 2-heptyl-3-hydroxy-4-qunolone (PQS) and its immediate precursor 2-heptyl-4-quinolone (HHQ). The genes responsible for the synthesis and effect of AQs include pqsABCDE, pqsH and pqsR. The pqsABCDE genes are arranged in a five-gene operon, the expression of which is under the control of the transcriptional regulator, PqsR. PqsABCD direct the synthesis ofHHQ and PqsH converts this molecule into PQS. To explore AQ synthesis and action, two new bioluminescent biosensor strains were developed for the simple, rapid and inexpensive detection of AQs in bacterial cultures using thin layer chromatography (TLC) and microplate assays. On TLC, both bioreporters were capable of sensitive detection of PQS, HHQ, 2-nonyl-3hydroxy- 4-quinolone (C9-PQS), 2-nonyl-4-quinolone (NHQ) and 2-heptyl-4quinolone N-oxide (HHQNO). Using microplate assays, the bioreporters responded primarily to HHQ then PQS, but were also activated by other AQs in a dosedependent manner, most notably NHQ and C9-PQS. The biosensors were also used successfully to evaluate AQ production after 8 h in a series of P. aeruginosa mutant
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Szamosvári, Dávid [Verfasser]. „Bacterial 2-Alkyl-4-Quinolones : Privileged Structures for the Synthesis of Bioactive Compounds / Dávid Szamosvári“. Konstanz : KOPS Universität Konstanz, 2020. http://d-nb.info/1205665358/34.

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Buchteile zum Thema "Alkyl-quinolones"

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Diggle, Stephen P., Matthew P. Fletcher, Miguel Cámara und Paul Williams. „Detection of 2-Alkyl-4-Quinolones Using Biosensors“. In Methods in Molecular Biology, 21–30. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-971-0_2.

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2

Fletcher, Matthew P., Stephen P. Diggle, Miguel Cámara und Paul Williams. „Detection of 2-Alkyl-4-Quinolones Using Biosensors“. In Methods in Molecular Biology, 25–34. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7309-5_2.

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3

Lahiri, Pallavi, und Dipankar Ghosh. „Single-Step Capture and Targeted Metabolomics of Alkyl-Quinolones in Outer Membrane Vesicles of Pseudomonas aeruginosa“. In Methods in Molecular Biology, 171–84. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6996-8_15.

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4

Lahiri, Pallavi, Priyakshi Gogoi und Dipankar Ghosh. „Single-Step Capture and Targeted Metabolomics of Alkyl-Quinolones in Outer Membrane Vesicles (OMVs) of Pseudomonas Aeruginosa“. In Methods in Molecular Biology, 201–16. New York, NY: Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-2966-6_18.

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