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1

Invisible invaders: Smallpox and other diseases in Aboriginal Australia, 1780-1880. Carlton South, VIC: Melbourne University Press, 2002.

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2

Goldsmid, John. The deadly legacy: Australian history and transmissible disease. Kensington, NSW, Australia: New South Wales University Press in association with the Australian Institute of Biology, 1988.

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3

Gattorna, Lynn. The hospitalisation of Aboriginal people in Western Australia, 1988-1992. Perth, W.A: Epidemiology Branch, State Health Purchasing Authority, Health Dept. of Western Australia, 1995.

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4

Briscoe, Gordon. Queensland Aborigines and the Spanish influenza pandemic of 1918-1919. Canberra, ACT: Australian Institute of Aboriginal and Torres Strait Islander Studies, 1996.

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5

Western Australia. Office of Aboriginal Health. The health of Aboriginal people in the [name of region] health region, 1993-1994. [Perth]: Office of Aboriginal Health and Health Information Centre, Health Dept. of Western Australia, 1996.

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6

Devitt, Jeannie. Living on medicine: A cultural study of end-stage renal disease among Aboriginal people. Alice Springs, N.T: IAD Press, 1998.

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7

Green, Frances. Chronic kidney disease in Aboriginal and Torres Strait Islander people 2011. Canberra: Australian Institute of Health and Welfare, 2011.

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8

Neil, Thomson. Overview of aboriginal health status in [name of region]. Canberra: Australian Govt. Print. Service, 1991.

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9

Western Australia. Office of Aboriginal Health. Hospitalisation for respiratory tract disease in western Australia, 1988-1993: A comparison of aboriginal and non-aboriginal hospital admission patterns. East Perth, W.A.]: Office of Aboriginal Health, Health Dept. of Western Australia, [1997, 1997.

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10

Briscoe, Gordon. Queensland Aborigines and the Spanish influence pandemic of 1918-1919. Canberra : Aboriginal Studies Press: 1996, 1996.

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11

B, Murray Richard, und Kimberley Aboriginal Medical Services' Council., Hrsg. Aboriginal primary health care: An evidence-based approach. Melbourne: Oxford University Press, 1999.

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12

Penm, Elizabeth. Cardiovascular disease and its associated risk factors in Aboriginal and Torres Strait Islander peoples, 2004-05. Canberra: Australian Institute of Health and Welfare, 2008.

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13

Unwin, Elizabeth. The impact of tobacco smoking and alcohol consumption on Aboriginal mortality and hospitalisation in Western Australia: 1983-1991. Perth: Health Dept. of Western Australia, 1994.

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14

Webb, Stephen. Prehistoric stress in Australian aborigines: A palaeopathological study of a hunter-gatherer population. Oxford, England: B.A.R., 1989.

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15

Webb, Stephen D. Prehistoric stress in Australian aborigines: A palaeopathological study of a hunter-gatherer population. Oxford, England: B.A.R., 1989.

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16

Webb, Stephen. Palaeopathology of aboriginal Australians: Health and disease across a hunter-gatherer continent. Cambridge: Cambridge University Press, 2009.

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17

Webb, Stephen. Palaeopathology of aboriginal Australians: Health and disease across a hunter-gatherer continent. Cambridge [England]: Cambridge University Press, 1995.

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18

Bonar, Maria. Just gettin' on with my life without thinkin' about it: The experiences of Aboriginal people in Western Australia who are HIV positive. Perth, W.A: Dept. of Health, 2004.

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19

Mathur, Sushma. Aboriginal and Torres Strait Islander people with coronary heart disease: Further perspectives on health status and treatment. Canberra: Australian Institute of Health and Welfare, 2006.

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20

Mathur, Sushma. Aboriginal and Torres Strait Islander people with coronary heart disease: Further perspectives on health status and treatment. Canberra: Australian Institute of Health and Welfare, 2006.

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21

Holman, C. D'Arcy J. Health and disease in the aboriginal population of the Kimberley region of Western Australia, 1980-1985. Perth: Health Dept. of Western Australia, 1986.

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22

Mathur, Sushma. Aboriginal and Torres Strait Islander people with coronary heart disease: Summary report : further perspectives on health status and treatment. Canberra: Australian Institute of Health and Welfare, 2006.

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23

Welfare, Australian Institute of Health and. Ear and hearing health of indigenous children in the Northern Territory. Canberra: Australian Institute of Health and Welfare, 2011.

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24

Jeannie, Devitt, McMasters Anthony und Devitt Jeannie, Hrsg. On the machine: Aboriginal stories about kidney troubles. Alice Springs, N.T: IAD Press, 1998.

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25

Occurrence and distribution of hepatitis B infection in the aboriginal population of Western Australia. Perth: Health Dept. of Western Australia, 1987.

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26

Couzos, Sophia, und H. P. Books. Couzos Aboriginal Primary Heal. Oxford University Press, 1999.

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27

Saethre, Eirik. Illness Is a Weapon: Indigenous Identity and Enduring Afflictions. Vanderbilt University Press, 2013.

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28

Anthony, Moore, und Australian Institute of Health and Welfare., Hrsg. Hospital procedures for diseases of the digestive tract in Aboriginal and Torres Strait Islander peoples and other Australians. Canberra: Australian Institute of Health and Welfare, 2008.

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29

Neil, Thomson, Hrsg. The health of indigenous Australians. South Melbourne, Victoria, Australia: Oxford University Press, 2003.

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30

Neil, Thomson, Hrsg. The health of indigenous Australian. Oxford: Oxford University Press, 2003.

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31

Campbell, Judy. Invisible Invaders: Smallpox and Other Diseases in Aboriginal Australia 1780-1880. Melbourne University Publishing, 2002.

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32

Webb, Stephen. Palaeopathology of Aboriginal Australians: Health and Disease Across a Hunter-Gatherer Continent. Cambridge University Press, 2010.

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33

Webb, Stephen. Palaeopathology of Aboriginal Australians: Health and Disease Across a Hunter-Gatherer Continent. Cambridge University Press, 2011.

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34

Luyckx, Valerie A. Nephron numbers and hyperfiltration as drivers of progression. Herausgegeben von David J. Goldsmith. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0138.

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Annotation:
The relationship between low birth weight (LBW) and subsequent increased risk of hypertension and renal disease in humans is now well established. The initial hypothesis suggested that an adverse intrauterine environment, reflected by LBW, would impact renal development, resulting in a low nephron number and predisposition to hypertension and renal disease. Studies in various populations have shown a direct correlation between birth weight and nephron number, and in infants, nephron numbers are reduced in those of LBW. Among Caucasian and Australian Aboriginal adults, lower nephron numbers are associated with higher blood pressure, whereas higher nephron numbers appear to protect against hypertension. LBW is currently the best clinical surrogate for low nephron number and has been independently associated with higher blood pressure from infancy through to adulthood in many populations, as well as an increased risk of proteinuria, reduced glomerular filtration rate, chronic kidney disease, and end-stage renal disease in later life. The pathophysiology is analogous to that in other chronic kidney diseases where surviving nephrons are subject to hyperfiltration early on, resulting in glomerular hypertrophy, proteinuria, and eventually, especially in the setting of other renal disease risk factors, glomerulosclerosis, and loss of renal function. Mean nephron number varies by up to 13-fold in certain populations, however, therefore nephron number is unlikely the sole developmentally programmed risk factor for renal disease in later life, but may be a first ‘hit’ impacting an individual’s susceptibility to or resistance to superimposed renal injury. Augmentation of nephron number perinatally has only been addressed in experimental settings. In humans, therefore optimization of nephron number is likely best achieved through good perinatal care and adequate postnatal nutrition. Cardiovascular disease and diabetes are also developmentally programmed and therefore likely coexist in subjects with LBW and low nephron numbers. Awareness of an individual’s birth weight should serve to highlight the possibility of low nephron number and potential risk for future hypertension and renal disease, which may be attenuated by optimization of early nutrition, lifestyle choices, and management of other risk factors for renal disease.
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