Zeitschriftenartikel: „823.7 f“

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Antolić, A., B. Kojić-Prodić, S. Tomić, B. Nigović, V. Magnus und J. D. Cohen. „Structural studies on monofluorinated derivatives of the phytohormone indole-3-acetic acid (auxin)“. Acta Crystallographica Section B Structural Science 52, Nr. 4 (01.08.1996): 651–61. http://dx.doi.org/10.1107/s0108768195016302.

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As part of the molecular recognition studies on the phytohormone indole-3-acetic acid (IAA) a series of fluorinated IAA's has been examined. The phenyl ring substitution at positions 4, 5, 6 and 7 resulted in four compounds, which were analyzed. Structure–activity correlation includes the analysis of their molecular conformations, based on the X-ray diffraction and computational chemistry results, and bioactivity determinations in the Avena coleoptile and the Pisum sativum stem straight-growth tests, lipophilicity and UV absorbance. The conformations of monofluorinated IAA's and a free hormone are defined by rotations about two bonds: one describes the relative orientation of a side chain towards the indole plane and the second the orientation of the carboxylic group. The results of X-ray structure analysis revealed the folded shape of the molecules in all compounds studied. Molecular mechanics and dynamics located the folded conformation as the local minimum, but failed to detect the planar conformation as one of the local minima, which according to ab initio results on IAA and 4-CI-IAA could also be possible. Crystal data at 295 K for 4-F-IAA and at 297 K for 5-F-IAA, and at 100 K for 6-F-IAA and 7-F-IAA using Mo Kα radiation (λ = 0.71073 Å) and Cu Kα (λ = 1.5418 Å, for 7-F-IAA), are as follows: 4-F-IAA, C10H8NO2F, Mr = 193.18, monoclinic, C2/c, a = 17.294 (5), b = 13.875 (4), c = 7.442 (4) Å, β = 103.88 (6)°, V = 1734 (1) Å3, Z = 8, Dx = 1.480 g cm−3, μ = 1.1 cm−1, F(000) = 800, R = 0.043, wR = 0.044 for 823 symmetry-independent [I ≥ 3σ(I)] reflections; 5-F-IAA, C10H8NO2F, monoclinic, P21/c, a = 19.284 (5), b = 5.083 (4), c = 9.939 (4) Å, β = 117.28 (6)°, V = 865.9 (1) Å3, Z = 4, Dx = 1.482 g cm−3, μ = 1.1 cm−1, F(000) = 400, R = 0.062, wR = 0.057 for 729 symmetry-independent [I ≥ 3σ(I)] reflections; 6-F-IAA, C10H8NO2F, monoclinic, P21/a, a = 9.360 (1), b = 5.167 (4), c = 17.751 (4) Å, β = 93.75 (1)°, V = 856.7 (8) Å3, Z = 4, Dx = 1.498 g cm−3, μ = 1.1 cm−1, F(000) = 400, R = 0.048, wR = 0.048 for 1032 symmetry-independent [I ≥ 2σ(I)] reflections; 7-F-IAA, C10H8NO2F, monoclinic, P21/a, a = 9.935 (5), b = 5.0059 (4), c = 17.610 (1) Å, β = 102.13 (1)°, V = 856.3 (1) Å3, Z = 4, Dx = 1.498 g cm−3, μ = 9.8 cm−1 (Cu Kα, F(000) = 400, R = 0.035, wR = 0.040 for 1504 symmetry-independent [I ≥ 2σ(I)] reflections.

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Hasegawa, Yoshiaki, Jeffrey J. Mans, Song Mao, M. Cecilia Lopez, Henry V. Baker, Martin Handfield und Richard J. Lamont. „Gingival Epithelial Cell Transcriptional Responses to Commensal and Opportunistic Oral Microbial Species“. Infection and Immunity 75, Nr. 5 (16.02.2007): 2540–47. http://dx.doi.org/10.1128/iai.01957-06.

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ABSTRACT Transcriptional profiling and ontology tools were utilized to define the biological pathways of gingival epithelial cells modulated by coculture with the oral commensal Streptococcus gordonii and the opportunistic commensal Fusobacterium nucleatum. Overall, F. nucleatum and S. gordonii perturbed the gingival epithelial cell transcriptome much less significantly than the oral pathogens Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans perturbed the transcriptome, indicating that there was a greater degree of host adaptation by the commensal species (M. Handfield, J. J. Mans, G. Zheng, M. C. Lopez, S. Mao, A. Progulske-Fox, G. Narasimhan, H. V. Baker, and R. J. Lamont, Cell. Microbiol. 7:811-823, 2005). The biological pathways significantly impacted by F. nucleatum and S. gordonii included the mitogen-activated protein kinase (MAPK) and Toll-like receptor signaling pathways. Differential regulation of GADD45 and DUSP4, key components of the MAPK pathway, was confirmed at the protein level by Western blotting. Modulation of the MAPK pathway is likely to affect host cell proliferation and differentiation. In addition, both the MAPK and Toll-like receptor pathways ultimately converge on cytokine gene expression. An enzyme-linked immunosorbent assay of secreted interleukin-6 (IL-6) and IL-8 demonstrated that F. nucleatum induced production of these cytokines, whereas S. gordonii inhibited secretion from the epithelial cells. Stimulation of secretion of proinflammatory cytokines from epithelial cells may reflect the invasive phenotype of F. nucleatum and contribute to the greater pathogenic potential of F. nucleatum than of S. gordonii.

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NDIFON, M'jaika, Margaret CHIV, Paul INYANG, Emmanuel ANKRUMAH, Chidiebere P. O. EMEKA und Ikechukwu CHINAKA. „Inhibition of Fusarium oxysporum wilt of scarlet eggplant (Solanum aethiopicum) using plant extracts“. Notulae Scientia Biologicae 14, Nr. 2 (06.06.2022): 10912. http://dx.doi.org/10.55779/nsb14210912.

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Solanum aethiopicum cultivation is highly constrained by Fusarium wilt. A trial was conducted to control soil-borne and seed-borne F. oxysporum f.sp. melongenae using botanicals (ginger and garlic extracts). Seeds of Bello variety of eggplant were used for the trial. The trial was set up using completely randomized design with nine treatments and each treatment replicated thrice. Data were collected on percentage germination, shoot height, number of leaves, plant vigour, shoot weight, disease incidence and disease severity. The results shows that treatment T9 has the lowest percentage germination (18.3%) at 7 DAS which is lower than T1 (44.2%) or mean (48.1%). T7 permits 72.5% germination which is at par with T6 (83.3%) at 15 DAS. Based on germination, T8, T5, T6 and T7 tops the chart (≥ 72.3% germination) compared to T9 (50.8%) at 15 DAS. The incidence of wilt is highest (33.4%) in T9 compared to all treated plots. T4, and T2 are the best treatments (0.0% incidence) at 45 DAS. Percentage severity of wilt follows the same trend as incidence. Based on shoot weight, T8 (8.3 g) and T7 (7.0 g) are the best treatments. The highest vigour index (45 DAS) is from T3 (823) followed by T2 (769), T5 (692), T7 (658) then T1 (604) in descending order of vigour index and mean vigour index is 582. It is concluded that the infection of eggplant by Fusarium sp. affects germination of seeds and subsequent growth in the absence of control measures. However, control of Fusarium sp. is possible with the use of botanicals.

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Barlow, R., H. Hearnshaw, P. F. Arthur und R. E. Darnell. „Evaluation of Hereford and first-cross cows on three pasture systems. I. Calf growth and reproductive performance of young cows“. Journal of Agricultural Science 122, Nr. 1 (Februar 1994): 121–29. http://dx.doi.org/10.1017/s0021859600065862.

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SUMMARYHereford (H × H), Brahman × Hereford (B × H), Simmental × Hereford (S × H) and Friesian × Hereford (F × H) females born over a 5-year period (1973–77) were placed on pastures of high, medium or low nutritive value at Grafton, New South Wales, Australia, at weaning (7–8 months of age). The first mating of heifers on high pasture was at 15 months (1974) while that on medium and low pastures was delayed until 27 months of age (1975). This paper reports the reproductive performance of these cows up to 5 years of age and the preweaning growth of their calves which were sired by Hereford bulls at Grafton, Australia. In total, 1222 calving records were analysed.Most traits were subject to interaction between genotype and other main effects (pasture, year of birth of cow, cow age and sex of calf). Eyelid pigmentation was an exception, with calves from B × H cows having more than calves of other genotypes (73 v. 43%). There were significant genotype differences in calving difficulty among 2-year-old heifers only, with H × H (33%) requiring more assistance than F × H (15%) and SxH (10%) heifers, while B × H heifers did not require any assistance. Genotype differences in percentage of calves born and weaned were observed on low pastures only, where B × H (66% born, 65% weaned) exceeded H × H (48%, 39%) and S × H (39%, 38%) cows, with F × H (58%, 50%) cows being intermediate. Calves by H × H cows were the slowest-growing and were the lightest at weaning on all pastures, with mean gains of 759, 604 and 340 g/day, and mean weaning weights of 212, 188 and 110 kg, on high, medium and low quality pastures, respectively. F × H and S × H cows produced the fastest-growing calves on high quality pasture (966 and 936 g/day, respectively) while B × H cows produced the fastest-growing calves on medium (823 g/day) and low (679 g/day) quality pastures. F × H cows weaned the heaviest calves on high quality pasture (274 kg) while F × H and B × H weaned the heaviest calves on medium (230 and 229 kg, respectively) and low (162 and 169 kg, respectively) quality pastures. Differences in body measurements followed a pattern similar to weaning weight.

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Pich Mitjana, Josep, und David Martínez Fiol. „Manuel Brabo Portillo. Policía, espía y pistolero (1876-1919)“. Vínculos de Historia. Revista del Departamento de Historia de la Universidad de Castilla-La Mancha, Nr. 8 (20.06.2019): 387. http://dx.doi.org/10.18239/vdh_2019.08.20.

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RESUMEN:El objetivo del artículo es aproximarnos a la controvertida biografía del comisario Manuel Brabo Portillo. El trabajo está basado en fuentes primarias y secundarias. El método utilizado es empírico. En el imaginario del mundo sindicalista revolucionario, Brabo Portillo era el policía más odiado, la reencarnación de la cara más turbia del Estado. Fue, así mismo, un espía alemán relacionado con el hundimiento de barcos españoles, el asesinato del empresario e ingeniero Barret y el primer jefe de los terroristas vinculados a la patronal barcelonesa. La conflictividad que afectó a España en el período de la Primera Guerra Mundial es fundamental para entender los orígenes del terrorismo vinculado al pistolerismo, que marcó la historia político social española del primer tercio del siglo XX.PALABRAS CLAVE: Brabo Portillo, pistolerismo, espionaje, sindicalismo, Primera Guerra Mundial.ABSTRACT:The objective of the article is an approach to the controversial biography of Police Chief Manuel Brabo Portillo. The work is based on primary and secondary sources. The method used is empirical. In the imagery of the revolutionary syndicalist world, Brabo Portillo was the most hated policeman, the reincarnation of the murkiest face of the state. He was also a German spy connected with the sinking of Spanish ships, the murder of businessman and engineer Josep Barret and the first head of the terrorists linked to Barcelona employers. The conflict that affected Spain during the period of the First World War is fundamental in order to understand the origins of terrorism linked to pistolerismo, which marked Spanish social political history during the first third of the twentieth century.KEY WORDS: Brabo Portillo, pistolerismo, espionage, syndicalism, First World War. BIBLIOGRAFÍAAisa, M., La efervescencia social de los años 20. Barcelona 1917-1923, Barcelona, Descontrol, 2016.Aguirre de Cárcer, N., La neutralidad de España durante la Primera Guerra Mundial (1914-1918). I. Bélgica, Madrid, Ministerio de Asuntos Exteriores, 1995.Alonso, G., “’Afectos caprichosos’: Tradicionalismo y germanofilia en España durante la Gran Guerra”, Hispania Nova, 15, 2017, pp. 394-415.Amador, A., El Terror blanco en Barcelona. Las bombas y los atentados personales. Actuación infernal de una banda de asesinos al servicio de la burguesía. El asesinato como una industria, Tarragona, Talleres gráf. 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(coord.), Anatomía de una crisis. 1917 y los españoles, Madrid, Alianza, 2017.Granados de Siles, J., “El escandaloso espionaje de Barcelona”, Solidaridad Obrera, 793 (19/6/1918), p. 1.Gual Villalbí, P., Memorias de un industrial de nuestro tiempo, Barcelona, Sociedad General de Publicaciones, [193?].León-Ignacio, J., Los años del pistolerismo. Ensayo para una guerra civil, Barcelona, Planeta, 1981.León-Ignacio, J., “Brabo Portillo, comisario y político”, Historia y vida, 181 (1983), pp. 68-73.Llates, R., 30 anys de vida catalana, Barcelona, Aedos, 1969.Madrid, F., Ocho meses y un día en el Gobierno Civil de Barcelona (confesiones y testimonios), Barcelona-Madrid, Las ediciones de la flecha, 1932.Manent, J., Records d’un sindicalista llibertari català, 1916-1943, París, Edicions Catalanes de París, 1976.Marquès, J., Història de l’organització sindical tèxtil “El Radium”, Barcelona, La Llar del Llibre, 1989.Márquez, B. y Capo, J. M., Las Juntas militares de defensa, Barcelona, Librería Sintes, 1923.Martínez Fiol, D., El catalanisme i la Gran Guerra (1914-1918). Antologia, Barcelona, La Magrana, 1988.Martínez Fiol, D. y Esculies Serrat, J., L’Assemblea de Parlamentaris de 1917 i la Catalunya rebel, Barcelona, Generalitat de Catalunya, 2017.Martínez Fiol, D. y Esculies Serrat, J., 1917. El año en que España pudo cambiar, Sevilla, Renacimiento, 2018.M.C.C., “El ‘affaire’ Brabo Portillo”, publicado en El Parlamentario y reproducido por Solidaridad Obrera, 926 (2/11/1918), p. 1.Mendoza, E., La verdad sobre el caso Savolta, Barcelona, Seix y Barral, 1975.Morales Lezcano, V., El colonialismo hispano-francés en Marruecos (1898-1927), Madrid, Siglo XXI, 1976.Navarra, A., 1914. Aliadófilos y germanófilos en la cultura española, Madrid, Cátedra, 2014.Navarra, A., Aliadòfils i germanòfils a Catalunya durant la Primera Guerra Mundial, Barcelona, Generalitat-CHCC, 2016.Nisk, “¡Inocente Brabo!”, Solidaridad Obrera, 789 (15/6/1918), p, 1.Pestaña, Á.,“A vuela pluma” y “En Libertad”, Solidaridad Obrera, 840-841 (5-6/8/1918), p. 1.Pestaña, Á., Terrorismo en Barcelona. Memorias inéditas, Barcelona, Planeta, [1979].Pradas Baena, M. A., L’anarquisme i les lluites socials a Barcelona 1918-1923. La repressió obrera i la violència, Barcelona, PAM, 2003.Pujadas, X., Marcel·lí Domingo i el marcel·linisme, [Barcelona], PAM, 1996.Roig, M., Rafael Vidiella. L’aventura de la revolució, Barcelona, Laia, 1976.Romero Salvadó, F. J., “Crisi, agonia i fi de la monarquía liberal (1914-1923)”, Segle XX. Revista catalana d’història, 1 (2008), pp. 57-82.Romero Salvadó, F. J. y Smith, A. (eds.), The Agony of Spanish Liberalism. 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Fajriana, Nurul, Ulia Hanum und Nurhidayatun Rahma. „ETHNOBOTANICAL STUDY IDENTIFICATION OF PLANT TYPES THAT CAN BE USED IN ECOPRINT PRODUCTION“. BIOTIK: Jurnal Ilmiah Biologi Teknologi dan Kependidikan 12, Nr. 1 (01.04.2024): 12. http://dx.doi.org/10.22373/biotik.v12i1.19431.

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ABSTRACT Used of synthetic dye in the textile industry produced liquid waste if it is not recycle with properly, it can cause pollution and contamination of water both on the surface and every drop used by humans, disrupting ecosystems and even killing life in aquatic ecosystems. Therefore, an alternative to synthetic dye is neededby using plants as natural dye. Leaves can be used for their color content, leaf bones and leaf surfaces can be used as textile motif called ecoprint. This research purposing to find out the types of plants that can be used as materials for making ecoprint as a substitute for synthetic dye and also to find out the parts of plants that can be used as materialfor making ecoprint. The research method used is descriptive qualitative from literature study and literature references regarding data and information related to research. The results showed there are 30 types of plants that can be used in ecoprint. Thishabitus plants is herbaceous, vines, shrubs, shrubs and trees. From herbaceous habitus found 5 species of plants, 3 species of vine habitus, 7 species of bush habitus, 10 species of shrub habitus and 5 species of tree habitus. The parts of plants that can be used in making ecoprints are the leaves, flowers, stems and roots. The results showed there were 30 species of plants from 21 families that could be used in making ecoprint. The parts of plant can be used in making ecoprintare parts, leaves, flowers, stems and roots, but not all parts of every type of plant can be used in the process of making ecoprint. Keywords: Ethnobotanical Studies, Ecoprint, Synthetic Dyes, Natural Dyes, HabitusREFERENCE[1] Lubis, E. F. M. D., Ghea, A., Viola, D. E, dan Soraya, G. D. 2022. Pemanfaatan Daun dan Bunga Tanaman Buah sebagai Pewarna Motif Alami pada Media Jilbab dengan Teknik Ecoprint. Jurnal Senashtek, hal:819-823.[2]Juniar, , S., T. dan Sulandjari S. 2018. Perbedaan Hasil Rok Pias EcoprintDaun Jati (Tectona grandis) Menggunakan Jenis dan Massa Mordan Tawas dan Cuka. Jurnal Tata Busana, 7. [3] Martani, E., Margino S. dan Nurnawati E. 2011. Isolasi Dan Karakterisasi Jamur Pendegradasi Zat Pewarna Tekstil (Isolation and Characterization of Dye-degrading Fungi). Jurnal Manusia dan Lingkungan, 18, 127-136. [4] Subagyo, P., K. & Seolistyowati. 2021. Pengaruh Zat Pewarna Sintetis terhadap Pewarnaan Kain Batik. Jurnal FOLIO. Vol. 2., No., 2. [5]Komarawidjaja, W. 2016. Sebaran Limbah Cair Industri Tekstil dan Dampaknya pada Beberapa Desa Kecamatan Rancaekek Kabupaten Bandung. Jurnal Teknologi Lingkungan. Vol. 17. No. 2., hal: 118-125. [6] Enrico. 2019. Dampak Limbah Cair Industri Tekstil Terhadap Lingkungan dan Aplikasi Tehnik Eco Printing sebagai Usaha Mengurangi Limbah. Jurnal MODA. Vol.1., No. 1. [7] Masyitoh F. dan Ernawati E. 2019. Pengaruh Mordan Tawas dan Cuka Terhadap Hasil Pewarnaan Ecoprint Bahan Katun Menggunakan Daun Jati (Tectona grandis). Gorga Jurnal Seni Rupa, 8, 387-391. [8] Saraswati, R., M. H. Dewi, S., Ratri, C. R., Fajar, D. P. 2019. Pemanfaatan Daun untuk Ecoprint dalam Menunjang Pariwisata. Depok: Departemen Geografi FMIPA UI. [9] Wirawan, B., M. Alvin. 2019. Teknik Pewarnaan Alam Ecoprint Daun Ubi dengan Penggunaan Fiksator Kapur, Tawas dan Tunjung. Jurnal Litbang Kota Pekalongan: Vol. 17:1-5. [10] Simanungkalit, Y., S. 2020. Teknik Ecoprint dengan Memanfaatkan Limbah Mawar (Rosa Sp.) pada Kain Katun. Skripsi. Semarang: UNNES. [11] Sugiyono, 2013. Metode Penelitian Pendidikan Pendekatan Kuantitatif, Kualitatif; Research & Development. Bandung: Alfabeta. [12] Baharuddin A., Aisyah A., Saokani J. dan Risnah I. A. 2015. Karakterisasi Zat Warna Daun Jati (Tectona Grandis) Fraksi Metanol: N-Heksana sebagaiPhotosensitizer pada Dye Sensitized Solar Cell. Chimica et Natura Acta, 3. [13] Kembaren R., Putriliniar S., Maulana N., Yulianto K., Ikono r., Rochman N. T.dan Mardliyati, E. 2014. Ekstraksi dan Karakterisasi Serbuk Nano Pigmen dari Daun Tanaman Jati (Tectona grandis linn. F). Jurnal Kimia dan Kemasan, 36.[14] Sulistiawati E. dan Swastika P. 2017. Ekstraksi Zat Warna Alami dari Daun JatiMuda (Tectona grandis) dan Kayu Secang (Caesalpinia sappan) dengan Metode Ultrasound Assisted Extraction untuk Aplikasi Produk Tekstil. Skrispsi. Surabaya:InstitutTeknologi Sepuluh Nopember. [15] Koswara S. 2009. Pewarna Alami Produksi dan Penggunaannya. Ebook Pangan. [16] Haffida A. A. N. dan Rahardhian F. D. 2017. Ekstraksi Zat Tanin Dari Bahan Alami Dengan Metode Steam Extraction.Skrispsi. Surabaya:Institut Teknologi Sepuluh Nopember.

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Гордиенко, Татьяна Александровна, und Станислав Григорьевич Гордиенко. „ДИНАМИКА ПОПУЛЯЦИИ ОЛЕНЬКА ОБЫКНОВЕННОГО (DORCUS PARALLELIPIPIDUS L., 1758) В ГОРОДСКОМ ПАРКЕ“. Российский журнал прикладной экологии, Nr. 2 (25.06.2021): 4–9. http://dx.doi.org/10.24852/2411-7374.2021.2.4.9.

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В 2018-2020 гг. исследована популяции оленька обыкновенного (Dorcus parallelipipedus L.), занесенного в Красную книгу Республики Татарстан, на территории парка «Крылья Советов» г. Казани. Установлено, что продолжительность периода активности жука составляет 95‒105 дней. Ведущим фактором динамики уловистости D. parallelipipedus на территории парка является температура воздуха. В 2019 г. произошло сильное смещение и сокращение сроков активности жука из-за пониженных температур во второй половине лета. К 2020 г. численность оленька сократилась в 2.4 раза. На это оказали влияние высокая рекреационная нагрузка в парке и погодные условия. Среди собранных жуков в большей мере преобладали погибшие особи (80%). Соотношение полов в популяции оленька обыкновенного в 2018 г. было оптимально равновесным, а в 2020 г. количество самок стало в 2.3 раза больше самцов. Библиографические ссылки 1. Берлов Э.Я., Кабакова О.Н. Атлас рогачей (Lucanidae) России // URL: https://www.zin.ru/Animalia/Coleoptera/rus/lucanida.htm (дата обращения: 21.01.2021). 2. Гершензон С.М. Основы современной генетики. Киев: Наукова думка, 1983. 558 с. 3. Красная книга Республики Татарстан: животные, растения, грибы. Казань: Природа, ТОО «Стар», 1995. 454 с. 4. Красная книга Республики Татарстан: животные, растения. Изд. 2-е. Казань: Идел–Пресс, 2006. 832 с. 5. Красная книга Республики Татарстан: животные, растения, грибы. Изд. 3-е. Казань: Идел–Пресс, 2016. 760 с. 6. Кузовенко А.Е., Киреева А.С., Мазяркина Т.Н. Находка оленька Dorcus parallelipipedus (Linnaeus, 1758) (Coleoptera:Lucanidae) в Казахстане // Кавказский энтомологический бюллетень. 2019. Т. 15, вып. 1. С. 59–60. 7. Экология города Казани. Казань: Изд-во «Фэн» Академии наук РТ, 2005. 576 с. 8. Alexander K.N.A., Mannerkoski I., Pettersson R., Mason F., Schmidl J. Dorcus parallelipipedus // The IUCN Red List of Threatened Species. 2010. e.T157667A5120866. 9. Bartolozzi L., Sprecher-Uebersax E. Lucanidae // Catalogue of Palaearctic Coleoptera. Vol. 3. Scarabaeoidea – Scirtoidea – Dascilloidea – Buprestoidea – Byrrhoidea. Apollo Books, Stenstrup, Denmark, 2006. P. 63–77. 10. Bartolozzi L., Ghahari H., Sprecher-Uebersax E., Zilioli M. A checklist of stag beetles (Coleoptera: Scarabaeoidea: Lucanidae) from Iran // Zootaxa. 2014. V. 3887, №3. P. 422–436. 11. Della Rocca F., Stefanelli S., Cardarelli E., Bogliani G., Bracco F. Contribution to the knowledge of the arthropods community inhabiting the winter-flooded meadows (marcite) of northern Italy // Biodiversity data journal. 2021. 9. e57889. https://doi.org/10.3897/BDJ.9.e57889. 12. Dorcus parallelipipedus (Linnaeus, 1758) in GBIF Secretariat. GBIF Backbone taxonomy. 2019. https://doi.org/10.15468/39omei. 13. Hardersen S., Ilaria T., Paolo C., Gianfranco C., Piero L., Gianluca N., Fabio P., Emanuele P., Giuseppe P. Survey of selected beetle families in a floodplain remnant in northern Italy // Bulletin of insectology. 2012. V. 65, №2. P. 199–207. 14. Paulsen M.J. Stag beetles of the genus Dorcus MacLeay in North America (Coleoptera, Lucanidae) // Current advances in Scarabaeoidea research. ZooKeys. 2010. V. 34. P. 199–207. DOI: 10.3897/zookeys.34.292. 15. Linnaei C. Systema Naturae Per Regna Tria Naturae, Secundum Classses, Ordines, Genera, Species, Cum Characteribus, Differentiis, Synonymis, Locis. Editio Decima, Reformata. Holmiae [Stockholm]: Impensis Direct. Laurentii Salvii. 1758. Bl. 823 p.

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Гордиенко, Татьяна Александровна, Раиса Анатольевна Суходольская, Юлия Александровна Лукьянова und Дмитрий Николаевич Вавилов. „ВЛИЯНИЕ НАРУШЕНИЙ ПОЧВЕННОГО ПОКРОВА НА СТРУКТУРНУЮ ОРГАНИЗАЦИЮ ПОЧВЕННОЙ МЕЗОФАУНЫ ПОЙМЕННО-ЛУГОВЫХ СООБЩЕСТВ НАЦИОНАЛЬНОГО ПАРКА «НИЖНЯЯ КАМА»“. Российский журнал прикладной экологии, Nr. 2 (06.07.2022): 12–19. http://dx.doi.org/10.24852/2411-7374.2022.2.12.19.

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В результате прокладки трубопроводов и установки стоек высоковольтной линии электропередач в границах Елабужских и Танаевских лугов Национального парка «Нижняя Кама» были нарушен растительный и почвенный покровы. В работе проведена оценка сообществ педобионтов нарушенных и контрольных участков лугов. Показано сокращение таксономического состава и обилия мезофауны на трансформированных участках, численность в них педобионтов соответствовала показателям среднего и низкого значения. На контрольных участках обилие и таксономическое разнообразие мезофауны оставалось высоким. Список литературы Бакин О.В., Рогова Т.В., Ситников А.П. Сосудистые растения Татарстана. Казань: Изд-во Казанского ун-та, 2000. 496 с. Вавилов Д. Н., Суходольская Р. А., Гордиенко Т. А., Лукьянова Ю.А. Воздействие прокладки инженерных коммуникаций на крупных почвенных беспозвоночных // Российский журнал прикладной экологии. 2020. №2. С. 8‒16. Государственный реестр особо охраняемых территорий в Республике Татарстан. Казань: Идел-Пресс, 2007. 408 с. Гордиенко Т.А., Вавилов Д.Н., Лукьянова Ю.А. Структурная организация сообщества наземных и почвенных беспозвоночных на естественных и нарушенных участках Танаевских лугов Национального парка «Нижняя Кама» // Труды Мордовского государственного природного заповедника имени П.Г. Смидовича. 2021. Вып. 28. С. 38‒50. Гордиенко Т.А., Вавилов Д.Н., Суходольская Р.А., Лукьянова Ю.А. Влияние антропогенной трансформации луговых экосистем Национального парка «Нижняя Кама» на сообщества наземных и почвенных беспозвоночных // Российский журнал прикладной экологии. 2017. №3. С. 7‒11. Гордиенко Т.А., Суходольская Р.А., Вавилов Д.Н., Лукьянова Ю.А. Устойчивость луговых сообществ педобионтов при антропогенной нагрузке // Концептуальные и прикладные аспекты научных исследований и образования в области зоологии беспозвоночных / Сборник статей V Междунар. конф. Томск: Изд-во Томского государственного ун-та, 2020. С. 59‒62. Дорохов К.В., Шелухо В.П., Кистерный Г.А. Сравнительное влияние антропогенных факторов на состав, трофическую структуру и плотность мезофауны // Лесной журнал. 2016. №5. С. 9‒21. Кадастр сообществ почвообитающих беспозвоночных (мезофауна) естественных экосистем Республики Татарстан. Казань: Изд-во Казанского ун-та, 2014. 308 с. Методы почвенно-зоологических исследований. М.: Наука, 1975. 280 с. Bagaria G., Helm A., Rodá F., Pino, J. Assessing coexisting plant extinction debt and colonization credit in a grassland-forest change gradient // Oecologia. 2015. Vol. 179. P. 823‒834. doi:1007/s00442-015-3377-4. Clavel J., Julliard R., Devictor V., Worldwide decline of specialist species: toward a global functional homogenization? // Frontiers in ecology and the environment. Vol. 94. P. 222–228. doi: 10.1890/080216. Figueiredo L., Krauss J., Steffan-Dewenter I., Cabral J.S., Understanding extinction debts: spatio-temporal scales, mechanisms and a roadmap for future research // Ecography. 2019. Vol. 42. P. 1973‒1990. doi: 1111/ecog.04740 Krauss J., Bommarco R., Guardiol, M. Habitat fragmentation causes immediate and time delayed biodiversity loss at different trophic levels // Ecology Letters. 2010. Vol. 3. P. 597‒605. doi: 1111/j.1461-0248.2010.01457.x Kuussaari M., Bommarco R., Heikkinen R.K. Extinction debt: a challenge for biodiversity conservation // Trends in ecology & evolution. Vol. 24. P. 564‒571. doi: 10.1016/ j.tree.2009.04.011 Lӧffler F., Poniatowsk D., Fartmann T. Extinction debt across three taxa in well-connected calcareous grasslands // Biological conservation. 2020. Vol. 246. P. 108588. вoi: 1016/j.biocon.2020.108588 Buisson E., Fidelis A., Overbeck G.E., Schmidt I.B., Durigan G., Young T.P., Alvarado S.T., Arruda A.J., Boisson S., Bond W., Coutinho A., Kirkman K., Oliveira R.S., Schmitt M.H., Siebert F.,Siebert S.J., Thompson D.I., Silveira F.A.O. A research agenda for the restoration of tropical and subtropical grasslands and savannas // Restoration ecology. 2021. Vol. 29. P. e13528. doi: 1111/rec.13292 Török P., Vida E., Deák B., Lengyel S., Tóthmérész B. Grassland restoration on former croplands in Europe: an assessment of applicability of techniques and costs // Biodiversity and conservation. 2011. Vol. 20. P. 2311‒2332.

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Singh, Devraj, Giridhar Mishra, Raj Kumar und Raja Ram Yadav. „Temperature Dependence of Elastic and Ultrasonic Properties of Sodium Borohydride“. Communications in Physics 27, Nr. 2 (24.08.2017): 151. http://dx.doi.org/10.15625/0868-3166/27/2/9615.

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We present the temperature dependent elastic and ultrasonic properties of sodium borohydride. The second and third order elastic constants of NaBH4 have been computed in the temperature range 0-300K using Coulomb and Born-Mayer potential. The sodium borohydride crystallizes into NaCl-type structure. The computed values of second order elastic constants have been applied to evaluate the temperature dependent mechanical properties such as bulk modulus, shear modulus, tetragonal modulus, Poisson’s ratio and Zener anisotropy factor and ultrasonic velocity to predict futuristic information about sodium borohydride. The fracture to toughness ratio (bulk modulus/shear modulus) in sodium borohydride varied from 1.91 to 1.62, which shows its behavioral change from ductile to brittle on increasing the temperature. Then, ultrasonic Grüneisen parameters have been computed with the use of elastic constants in the temperature regime 100-300K. The obtained results have been discussed in correlation with available experimental and theoretical results. [1] A. Amudhavalli, M. Manikandan, A. Jemmy Cinthia, R. Rajeswarapalanichamy and K. Iyakutti, Z. Naturforsch. A 72 (2017) 321. [2] D.Singh, P.K.Yadawa and S.K.Sahu, Cryogenics 50 (2010) 476. [3] V. Bhalla, D.Singh and S.K.Jain, Int. J. Comput. Mat. Sc. Eng. 5 (2016) 1650012. [4] S. Kaushik, D. Singh and G. Mishra, Asian J. Chem. 24 (2012) 5655. [5] D. Chernyshov, A. Bosak, V. Dmitriev, Y. Filmchuk and H. Hagemann, Phys. Rev. B 78 (2008)172104. [6] H. Hagemann, S. Gomes, G. Renaudin and K. Yvon, J. Alloys Compd. 363 (2004) 126. [7] Y. Filinchuk, D. Chernyshov and V. Dmitriev, Z. Kristallogr. 223 (2008) 649. [8] Z.Xiao Dong, J.Z. Yi, Z. Bo, H. Z. Feng and H.Y. Qing, Chin. Phys. Lett. 28(2011)076201. [9] T. Ghellab, Z. Charifi, H. Baaziz, Ş. Uğur, G. Uğur and F. Soyalp, Phys. Scr. 91 (2016) 045804. [10] S. Bae, S. Gim, H. Kim and K. Hanna, Appl. Catal. B: Environm. 182 (2016) 541. [11] G. Renaudin, S. Gomes, H. Hagemann, L. Keller and K. Yvon, J Alloys Compd. 375 (2004) 98. [12] P. Vajeeston, P. Ravindran, A. Kjekshus and H. Fjellvåg, J Alloys Compd. 387 (2005) 97. [13] S. Orimo, Y. Nakamori, J.R. Eliseo, A. Zuttel and C. M. Jensen, Chem. Rev. 107 (2007) 4111. [14] A. Istek and E. Gonteki, J. Environ. Bio.7 (2009) 951. [15] R. S. Kumar and A.L. Cornelinus, Appl. Phys. Lett. 87 (2005) 261916. [16] E. Kim, R. Kumar, P. F. Weck, A. L. Cornelius, M. Nicol, S. C. Vogel, J. Zhang, M. Hartl, A.C. Stowe, L. Daemen and Y. Zhao, J. Phys. Chem. Lett. B 111 (2007) 13873. [17] K. Brugger, Phys. Rev. 133 (1964) A1611. [18] P.B. Ghate, Phy. Rev. 139 (1965) A1666 [19] S. Mori, Y. Hiki, J. Phys. Soc. Jpn. 45 (1975) 1449. [20] V. Bhalla, R. Kumar, C. Tripathy and D. Singh, Int. J. Mod. Phys. B 27 (2013) 1350116. [21] D. Singh, S. Kaushik, S. Tripathi, V. Bhalla and A. K. Gupta, Arab. J. Sci. Eng. 39 (2014) 485. [22] K. Brugger, Phys. Rev.137 (1965) 1826. [23] W. P. Mason, Physical Acoustics, vol. IIIB, Academic Press, New York, 1965. [24] M.P. Tosi, Solid State Physics, vol. 12, Academic Press, New York, 1965. [25] Y. Nakamori and S. Orimo, J. Alloy Compd.370(2004)271. [26] D. Singh, D.K. Pandey and P.K. Yadawa, Cent. Eur. J. Phys. 7 (2009) 198. [27] V. Bhalla, D. Singh, G. Mishra and M. Wan, J. Pure Appl. Ultrason. 38 (2016)23. [28] D. Singh, S. Kaushik, S.K. Pandey, G. Mishra and V. Bhalla, VNU J. Sc.: Math. Phys. 32(2016)43. [29] J.P.Watt and L. Peselnick, J.Appl. Phys. 51 (1980) 1525. [30] S.F.Pugh, Philos.Mag. 45 (1954) 823. [31] V. Bhalla, D. Singh and S.K. Jain, Int. J. Thermophys. 37(2016)33. [32] V. Bhalla, D. Singh, S.K. Jain and R. Kumar, Pramana- J. Phys. 86 (2016)135.

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De Santis, S., V. Donato, M. R. Migliorino, B. Tedesco, S. Condo und F. De Marinis. „Stage III non small lung cancer (NSCLC): Docetaxel (D), gemcitabine (G), and cisplatin (C) as induction chemotherapy, an Italian phase I study“. Journal of Clinical Oncology 25, Nr. 18_suppl (20.06.2007): 18201. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.18201.

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18201 Background: Based on the several clinical trials, combined modality therapy became the standard of care for patients with stage III NSCLC “unresectable” with good performance status (Kathy S. Albain, Educational Book ASCO 2006, 453–461; Thomas E. Stinchcombe, Oncologist 2006, 11, 809–823). The most effective induction chemotherapy has yet to be determined. The objective of this prospective phase I study was to define the maximum tolerated dose (MTD), and to evaluate the activity and safety of one of the third generation triplets as a full dose neoadjuvant regimen in patients (pts) with unresectable Stage III NSCLC. Methods: In this study, chemotherapy-naïve pts with stage IIIA-N2 bulky and IIIB (except malignant pleural effusion) NSCLC were eligible. Inclusion into the trial and treatment decisions were done by multidisciplinary panel involving surgeons, medical oncologists and radiotherapists. All drugs were given intravenously on days 1 and 8, and repeated every 3 weeks up to 2 cycles followed by concurrent chemoradiation. D (30–35 mg/m2) was given first, followed by C (35 mg/m2) and G (1000 mg/m2). Results: From Jan ‘06 to Jul ‘06 twelve eligible pts were enrolled, 10/2 m/f gender; median age 63 (50–72), 1 patient with ECOG PS 0, 11 pts with PS 1; 5 pts with stage IIIA-N2 bulky, 7 pts with stage IIIB NSCLC; nine pts were smokers. All pts were evaluable for toxicity. Toxicity grade 3–4 by CTC criteria was: grade 3 neutropenia in 2/3 patients and grade 3 thrombocytopenia in 1/3 patients on the second dose level of chemotherapy (i.e. docetaxel 35 mg/m2), and was considered dose-limiting. Of 9 pts treated at the MTD (i.e. docetaxel 30 mg/m2), only 1 patient developed grade 4 neutropenia and 1 patient grade 3 thrombocytopenia; 3 patients (30%) had grade 2 neutropenia and grade 2 stomatitis. Of 12 evaluable pts for response, after induction chemotherapy eighty-three percent of patients (9/12 pts) had an objective response and 16,6% (2/9 pts) stable disease. Phase II is continuing for larger patient accrual. Conclusions: The recommended doses for further phase II studies are D (30 mg/m2) followed by C (35 mg/m2) and G (1000 mg/m2) every 3 weeks. This regimen is well tolerated and effective, and appears to be an excellent choice for stage III NSCLC. No significant financial relationships to disclose.

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Jaroszewicz, Zbigniew, Eugeniusz Czech und Tomasz Osuch. „Diffractive gratings with varying period’s shape“. Photonics Letters of Poland 11, Nr. 2 (01.07.2019): 41. http://dx.doi.org/10.4302/plp.v11i2.904.

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The aim of this short review is to recall various designs of diffraction gratings when the condition of the period’s identity is relaxed and to mention resulting thus some of their applications. Among others the apodization function can be implemented as a variable diffraction efficiency due to the gradual change of the period’s shape. Another possible application is the passive achromatization of the diffraction efficiency of the blazed gratings by randomizing their blaze angle. Full Text: PDF ReferencesP. Jacquinot and B. Roizen-Dossier, "II Apodisation", Prog. Opt. 3, 29 (1964). CrossRef H. Bartelt, "Computer-generated holographic component with optimum light efficiency", Appl. Opt. 23, 1499 (1984). CrossRef H. Bartelt, "Applications of the tandem component: an element with optimum light efficiency", Appl. Opt. 24, 3811 (1985). CrossRef N. Château, D. Phalippou, and P. Chavel, "A method for splitting a gaussian laser beam into two coherent uniform beams", Opt. Commun. 88, 33 (1992). CrossRef C.I. Robledo-Sánchez et al. "Binary grating with variable bar/space ratio following a geometrical progression", Opt. Commun. 119, 465 (1995). CrossRef S.Yu. Popov and A.T. Friberg, "Apodization of generalized axicons to produce uniform axial line images", Pure Appl. Opt. 7, 537 (1998). CrossRef S.Yu. Popov et al. "Scientists harvest antibodies from plants", Opt. Commun. 154, 359 (1998). CrossRef J. Albert et al. "Moire phase masks for automatic pure apodisation of fibre Bragg gratings", Electron. Lett. 32 2260 (1996). CrossRef J. Albert et al. "Apodization of the spectral response of fiber Bragg gratings using a phase mask with variable diffraction efficiency", Electron. Lett. 31, 222 (1995). CrossRef Z. Jaroszewicz, A.T. Friberg, and S.Yu. Popov, "Kinoform apodization", J. Mod. Opt. 47, 939 (2000). CrossRef Z. Jaroszewicz et al. "Kinoform apodization by using of programmable diffractive optical elements", Proc. SPIE 5456, 153 (2004). CrossRef F. Trépanier, M. Poulin, and G. Bilodeau, "Complex apodized holographic phase mask for FBG writing", Bragg Gratings, Photosensitivity, and Poling in Glass Waveguides, Technical Digest (Optical Society of America, 2003), paper WC5 CrossRef F .Ghiringhelli, F. Fundamental properties of Bragg gratings and their application to the design of advanced structures, PhD thesis, Univ. of Southampton, (2003). DirectLink T. Osuch, Z. Jaroszewicz, "Numerical analysis of apodized fiber Bragg gratings formation using phase mask with variable diffraction efficiency", Opt. Commun. 284, 567 (2011). CrossRef T. Osuch et al. "Fabrication of phase masks with variable diffraction efficiency using HEBS glass technology", Appl. Opt. 50, 5977 (2011). CrossRef T. Osuch and Z. Jaroszewicz, "Influence of optical fiber location behind an apodized phase mask on Bragg grating reflection efficiencies at Bragg wavelength and its harmonics", Opt. Commun. 382, 36 (2017). CrossRef T. Osuch, "Numerical analysis of the harmonic components of the Bragg wavelength content in spectral responses of apodized fiber Bragg gratings written by means of a phase mask with a variable phase step height", J. Opt. Soc. Am. A 33, 178 (2016). CrossRef Z. Jaroszewicz, T. Osuch, "Harmonic analysis of fiber Bragg gratings written using apodized phase and amplitude masks", Opt. Pura Aplic. 50, 259 (2017). CrossRef N. Davidson, A.A Friesem, and E. Hasman, "Efficient formation of nondiffracting beams with uniform intensity along the propagation direction", Opt. Commun. 88, 326 (1992). CrossRef A.T. Friberg, "Stationary-phase analysis of generalized axicons", J. Opt. Soc. Am. A 13, 743 (1996). CrossRef M. Honkanen, J. Turunen, "Tandem systems for efficient generation of uniform-axial-intensity Bessel fields", Opt. Commun. 154, 368 (1998). CrossRef S.Yu. Popov and A.T. Friberg, "Apodization of generalized axicons to produce uniform axial line images", Pure Appl. Opt. 7, 537 (1998). CrossRef A. Kowalik et al. "Apodised linear axicons", Proc. SPIE 7141, 714125 (2008). CrossRef M.J. Simpson, "Diffractive multifocal intraocular lens image quality", Appl. Opt. 31, 3621 (1992). CrossRef J.A. Davison and M.J. Simpson, "History and development of the apodized diffractive intraocular lens", J. Cataract Refract. Surg. 32, 849 (2006). CrossRef J.C. Alfonso et al. "Prospective visual evaluation of apodized diffractive intraocular lenses", J Cataract Refract Surg. 33, 1235 (2007). CrossRef F. Vega, F. Alba-Bueno, and M.S. Millán, "Energy Distribution between Distance and Near Images in Apodized Diffractive Multifocal Intraocular Lenses", Invest. Ophthalmol. Vis. Sci. 52, 5695 (2011). CrossRef F. Vega et al. "Halo and Through-Focus Performance of Four Diffractive Multifocal Intraocular Lenses", Invest Ophthalmol Vis Sci. 56, 3967 (2015). CrossRef J.P. Guigay, "On Fresnel Diffraction by One-dimensional Periodic Objects, with Application to Structure Determination of Phase Objects", Opt. Acta 18 677 (1971). CrossRef V. Arrizon and J. Ojeda-Castañeda, "Irradiance at Fresnel planes of a phase grating", J. Opt. Soc. Am. A 9, 1801 (1992). CrossRef G. Serrano-Heredia, G. Lu, P. Purwosumarto, and F.T.S. Yu, "Measurement of the phase modulation in liquid crystal television based on the fractional-Talbot effect", Opt. Eng. 35, 2680 (1996). CrossRef Z. Jaroszewicz et al. "Determination of the step height of the binary phase grating from its Fresnel images", Optik 111, 207 (2000). CrossRef L. Martínez-León et al. "Phase calibration of spatial light modulators by means of Fresnel images", J. Opt. A: Pure Appl. Opt. 11, 125405 (2009). CrossRef J.M. Rico-García and L.M Sanchez-Brea "Binary gratings with random heights", Appl. Opt. 48, 3062 (2009). CrossRef R. Brunner, Diffractive optical elements, in Springer Handbook of Lasers and Optics, F. Träger, ed., 2nd ed. (Springer, 2012), pp. 454-461. DirectLink Y. Arieli et al. "Design of diffractive optical elements for multiple wavelengths", Appl. Opt. 37, 6174 (1998). CrossRef Y. Arieli et al. "Design of a diffractive optical element for wide spectral bandwidth", Opt. Lett. 23, 823 (1998). CrossRef B.H. Kleemann, M. Seeßelberg, and J. Ruoff, "Design concepts for broadband high-efficiency does", J. Eur. Opt. Soc. Rapid 3, 08015 (2008). CrossRef T. Gühne and J. Barth, "Strategy for design of achromatic diffractive optical elements with minimized etch depths", Appl. Opt. 52, 8419 (2013). CrossRef H. Lajunen, J. Turunen, and J. Tervo, "Design of polarization gratings for broadband illumination", Opt. Express 13, 3055 (2005). CrossRef H. Lajunen, J. Tervo, and J. Turunen, "High-efficiency broadband diffractive elements based on polarization gratings", Opt. Lett 29, 803 (2004). CrossRef J. Pietarinen, T. Vallius, and J. Turunen, "Wideband four-level transmission gratings with flattened spectral efficiency", Opt. Express 14, 2583 (2006). CrossRef Y. Wang, Y. Kanamori, and K. Hane, "Pitch-variable blazed grating consisting of freestanding silicon beams", Opt. Express 17, 4419 (2009). CrossRef G. Minguez-Vega et al. "Diffraction efficiency achromatization by random change of the blaze angle", Proc. SPIE 4829, 1033 (2002). CrossRef E. Czech et al. "Diffraction Efficiency Achromatization of Blazed Gratings", EOS Topical Meeting on Diffractive Optics 2010, paper 2491. DirectLink E. Czech et al. "Analiza dokładności pomiaru, względnego rozkładu egzytancji widmowej źródeł światła, dokonanego przy użyciu spektroradiometru kompaktowego", Prz. Elektrotech. 91, 171 (2015) (in Polish). CrossRef

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Lee, S., S. Y. Kang, Y. H. Eun, H. Kim, H. S. Cha, E. M. Koh und J. Lee. „POS0972 CLUSTER ANALYSIS OF ANKYLOSING SPONDYLITIS PATIENTS REVEALS DIFFERENTIAL DRUG SURVIVAL OF ANTI-TNF AGENTS ACCORDING TO DISTINCT CLINICAL PHENOTYPE“. Annals of the Rheumatic Diseases 80, Suppl 1 (19.05.2021): 752.1–752. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1772.

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Background:Previous studies using cluster analysis technique in ankylosing spondylitis (AS) patients have consistently identified distinct groups of patients in terms of their clinical characteristics: those with pure axial symptoms and those with a high frequency of peripheral manifestations [1,2]. Due to the cross-sectional nature of these studies, however, prognostic information such as drug survival of anti-TNF agents in these group were not provided.Objectives:Using the data retrieved from Korean College of Rheumatology Biologics (KOBIO) registry, which includes longitudinal data of AS patients using anti-TNF agents, this study aims to perform cluster analysis to differentiate AS patients in terms of clinical phenotypes and to examine the differential drug survival of anti-TNF agents in these groups.Methods:Clinical characteristics and demographic data of AS patients in KOBIO registry were analyzed using hierarchical clustering analysis. After clustering, drug survivals of anti-TNF agents were compared between these groups.Results:1,046 patients were included in the study with no missing data. The hierarchical cluster analysis classified patients in two groups; one with predominant isolated axial manifestations (axial group, n=823) and the other with more frequent extra-axial symptoms (extra-axial group, n=223). Almost all extra-axial symptoms (peripheral arthritis, enthesitis, uveitis, dactylitis, and psoriasis) were more frequently observed in extra-axial group than axial group. In addition, patients with shorter disease duration, late disease onset, and high disease activity were classified in extra-axial group (Table 1). Interestingly, the extra-axial group had lower drug survival probability than the axial group (p=0.008, Figure 1).Conclusion:Cluster analysis of AS patients using anti-TNF agents classified two distinct groups of patients in terms of their clinical phenotypes and revealed that the patients with prominent extra-axial manifestations had lower drug survival with anti-TNF agents.References:[1]Costantino F, et al. Two Phenotypes Are Identified by Cluster Analysis in Early Inflammatory Back Pain Suggestive of Spondyloarthritis: Results From the DESIR Cohort. Arthritis Rheumatol. 2016 Jul;68(7):1660-8.[2]Porcher R, et al. Two major spondylarthropathy phenotypes are distinguished by pattern analysis in multiplex families. Arthritis Rheum. 2005 Apr 15;53(2):263-71.Table 1.Clinical characteristics of divided groupsGroup1 (axial group)2 (extra-axial group)pNumber of patients823223Age at start of TNFi (yr)38.21 (12.78)38.58 (14.17)0.713Disease duration (yr)3.95 (5.26)2.29 (4.32)<0.001Age at diagnosis34.27 (13.05)36.29 (14.11)0.044Sex (male) (%)645 (78.4)152 (68.2)0.002HLA-B27 positivity (%)736 (89.4)197 (88.3)0.732Inflammatory back pain (%)699 (84.9)191 (85.7)0.872Peripheral arthritis (%)201 (24.4)191 (85.7)<0.001Enthesitis (%)65 (7.9)154 (69.1)<0.001Uveitis (%)163 (19.8)59 (26.5)0.039Dactylitis (%)12 (1.5)13 (5.8)<0.001Psoriasis (%)15 (1.8)12 (5.4)0.006Good response to NSAIDs (%)205 (24.9)155 (69.5)<0.001Family history (%)88 (10.7)27 (12.1)0.632Smoking (%)408 (49.6)102 (45.7)0.347CRP (mg/dl)2.10 (2.74)2.89 (3.57)<0.001ESR (mm/hr)35.52 (28.73)46.33 (32.94)<0.001BASDAI5.93 (1.92)6.41 (1.80)0.001BASF3.42 (2.56)3.64 (2.58)0.255Drug change after one year (%)160 (19.4)61 (27.4)0.013Disclosure of Interests:None declared.

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Ling, K. S., J. Th J. Verhoeven, R. P. Singh und J. K. Brown. „First Report of Tomato chlorotic dwarf viroid in Greenhouse Tomatoes in Arizona“. Plant Disease 93, Nr. 10 (Oktober 2009): 1075. http://dx.doi.org/10.1094/pdis-93-10-1075b.

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Tomato chlorotic dwarf viroid (TCDVd), a member of the genus Pospivroid, family Pospiviroidae, was first identified on greenhouse tomato (Solanum lycopersicum) in Canada (2). Since then, it has also been reported elsewhere, e.g., on tomato in Colorado (4). During 2006 in Arizona, tomato plants in a large greenhouse facility with continuous tomato production exhibited viroid-like symptoms of plant stunting and chlorosis of the young leaves. Symptomatic plants were often located along the edge of the row, indicating the presence of a mechanical transmissible agent. Approximately 4% of the plants in this greenhouse were symptomatic in 2008. Symptoms were distinctly different from those caused by Pepino mosaic virus (PepMV), a virus that was generally present in this greenhouse and also in our test samples. Other commonly occurring tomato viruses were ruled out by serological, PCR, or reverse transcription (RT)-PCR tests in multiple laboratories. RT-PCR with two sets of universal pospiviroid primers, PospiI-FW/RE and Vid-FW/RE (4), yielded amplicons of the expected sizes of 196 and 360 bp in three samples collected from symptomatic plants. Direct sequencing of the amplicons revealed that the genome was 360 nt and 100% identical to the type TCDVd from Canada (GenBank Accession No. AF162131) (2). Mechanical inoculation with leaf tissue extract from four samples to plants of the tomato ‘Money-Maker’ resulted in the same viroid-like symptoms and TCDVd was confirmed in these plants by RT-PCR and sequencing. In both 2007 and 2008, 18 samples were tested using primers PSTVd-F and PSTVd-R (1), which are capable of amplifying the full TCDVd genome. Analysis of the sequences from the amplicons revealed two genotypes of TCDVd. The first genotype (GenBank Accession No. FJ822877) was identical to the type TCDVd and found in 11 samples from 2007 and one from 2008. The second genotype (GenBank Accession No. FJ822878) was 361 nt, differing from the first by nine nucleotide substitutions, 2 insertions, and 1 deletion. This second genotype was found in 7 and 17 samples from 2007 and 2008, respectively, and showed the highest sequence identity (97%) to a Japanese tomato isolate (AB329668) and a much lower sequence identity (92%) to a U.S. isolate previously identified in Colorado (AY372399) (4). The origin of TCDVd in this outbreak is not clear. The genotype identified first could have been introduced from a neighboring greenhouse where the disease was observed before 2006 and where this genotype also was identified in 2007. The second genotype may have been introduced from infected seed since TCDVd has recently been shown to be seed transmitted in tomato (3). To our knowledge, this is the first report of natural occurrence of TCDVd in Arizona. References: (1) A. M. Shamloul et al. Can. J. Plant Pathol. 19:89, 1997. (2) R. P. Singh et al. J. Gen. Virol. 80:2823, 1999. (3) R. P. Singh and A. D. Dilworth. Eur. J. Plant Pathol. 123:111, 2009. (4) J. Th. J. Verhoeven et al. Eur. J. Plant Pathol. 110:823, 2004.

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Gerçek, H., B. S. Unuvar, O. Umit Yemisci und A. Aytar. „AB1491 ACUTE EFFECTS OF AN INSTRUMENT ASSISTED SOFT TISSUE MOBILIZATION TECHNIQUE ON CHRONIC NECK PAIN: A DOUBLE-BLIND, RANDOMIZED CONTROLLED TRIAL“. Annals of the Rheumatic Diseases 81, Suppl 1 (23.05.2022): 1850.1–1850. http://dx.doi.org/10.1136/annrheumdis-2022-eular.134.

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BackgroundIndividuals with chronic neck pain, proprioceptive afferent information from the cervical spine may be impaired due to the presence of pain. Instrument-assisted soft-tissue mobilization (IASTM) is used to reduce pain and improve range of motion (ROM) and function.Cervical sensorimotor control includes the central integration and processing of all afferent information and the execution of the motor program through the cervical muscles and contributes to the maintenance of head posture and balance(1). In individuals with chronic neck pain, proprioceptive afferent information from the cervical spine may be impaired due to the presence of this pain(2). Many treatment modalities such as instrument-assisted soft-tissue mobilization (IASTM) have been used to reduce pain and increase proprioception(3).IASTM is used to reduce pain, increase soft-tissue mobility, and improve range of motion (ROM) and function. These instruments cause microtrauma to restore normal elasticity and function in soft-tissue(4). Kivlan has shown that significant and rapid changes in muscle function can occur with only a single IASTM application and have suggested the following mechanisms of action: an increased fascial motility, a proliferation of extracellular matrix fibroblasts, and an increased blood flow to the area close to the injured tissue, with decreased cellular matrix adhesion and localized ischemia(5).ObjectivesAim of this study, to determine the acute effects of single-session, IASTM on cervical joint position error (JPE) and pain in individuals with chronic neck pain.MethodsA total of 39 individuals (mean age=40.18±11.10 years) with chronic neck pain were included in this study. We divided the participants into IASTM, sham, and control groups of 13 members each. In the IASTM group, intervention was applied to the sternocleidomastoid and trapezius muscles with an application time of 45 seconds and a frequency of 60 beats/min. In the sham group, IASTM was applied at a 90° angle without pressure. The control group received no intervention. The pain severity and joint position error were evaluated before and after the intervention, by using the visual analog scale (VAS) and a cervical range of motion device.ResultsThe effects of time and treatment group on VAS score were statistically significant. The effect of time and treatment for VAS score was statistically significant (p=0.001). When the post-test was examined according to application, a statistically significant difference found in VAS scores (p=0.001), with the lowest pain score in the IASTM group and the highest pain score in the control group. The significant improvements found in JPE in all aspects of the cervical region in the IASTM group (p<0.05). In the sham group, significant improvements observed in cervical extension, left rotation, and left lateral flexion movements in JPE (p<0.05).ConclusionSingle-session IASTM is effective for improving the acute pain and JPE in individuals with chronic neck pain.References[1]Michiels S, De Hertogh W, Truijen S, November D, Wuyts F, Van de Heyning P. The assessment of cervical sensory motor control: A systematic review focusing on measuring methods and their clinimetric characteristics. Gait Posture. 2013;38(1):1–7.[2]Uremović M, Cvijetić S, Pasić MB, Serić V, Vidrih B, Demarin V. Impairment of proprioception after whiplash injury. Coll Antropol. 2007;31(3):823–7.[3]Damgaard P, Bartels EM, Ris I, Christensen R, Juul-Kristensen B. Evidence of Physiotherapy Interventions for Patients with Chronic Neck Pain: A Systematic Review of Randomised Controlled Trials. ISRN Pain. 2013;1–23.[4.]Baker RT, Nasypany A, Seegmiller JG, Baker JG. Instrument-Assisted Soft Tissue Mobilization Treatment for Tissue Extensibility Dysfunction. Int J Athl Ther Train. 2013;18(5):16–21.[5]Kivlan BR, Carcia CR, Clemente FR, Phelps AL, Martin RL. The effect of Astym Therapy on muscle strength: a blinded, randomized, clinically controlled trial. BMC Musculoskelet Disord. 2015;16(1):325.Disclosure of InterestsNone declared

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Mazacón Gómez, Martha Narcisa, Cindy del Rocío Paliz Sánchez und Luis Antonio Caicedo Hinojosa. „LAS COMPETENCIAS PROFESIONALES DE LA ENFERMERÍA Y SU EFECTO EN LA LABOR PROFESIONAL“. Universidad Ciencia y Tecnología 24, Nr. 105 (11.10.2020): 72–78. http://dx.doi.org/10.47460/uct.v24i105.383.

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Distintos autores aseguran que el desarrollo profesional de la enfermería debe tener un enfoque vinculante que relacione la gestión, la administración y las competencias profesionales. La enfermería es hoy una profesión de primer orden en el sistema de salud universal, reconocida como protagonista principal en el cuidado y atención del paciente, lo que obliga a estos profesionales conocimientos actualizados que se manifiestan en su desempeño. Por ello, esta investigación examina las teorías sobre competencia, gestión y la administración en el ejercicio de la enfermería, mediante una revisión bibliográfica en bases de datos atendiendo los criterios de inclusión y exclusión elegidos. Una vez realizada la búsqueda se seleccionaron 11 documentos relacionados con el objetivo de la investigación. Sobre la base de una revisión crítica del referencial teórico, se identificó los conocimientos, capacidad, liderazgo, compromiso social y comunicación de la enfermería como eje central en el cuidado integral del paciente y el desarrollo integral del profesional de la enfermería. Palabras Clave: gestión, administración, enfermería, calidad profesional. Referencias [1]A.Orellana y O. Sanhueza, "Competencia en investigación en enfermería," Ciencia y Enfermería, vol. XVII, nº 2, p. 15-23, 2011. [2]Consejo Internacional de enfermeras , "Informe del proceso de elaboración de consultas del Consejo Internacional de enfermeía", Munich, 2003. [3]Sociedad Española de Enfermería , "Competencias de enfermería en urgencias y emergencia", Ginebra, 1998. [4]P.Ramritu y D. Barnard, "Cómo comprenden la competencia los enfermeros recien licenciados", International Nursing Review version española, vol. 48, nº 1, pp. 41-61, 2001. [5]R.Samper, "Gestion del cuidado de enfermería para la atencion cerrada", Rev Cubana Enfermer, vol. 26, nº 1, pp. 1-12, 2010. [6]M.Asenjo, "Gestión diaria en el hospital", Rev. Esp. Salud Pública, vol. 3, nº 73, pp. 417-419, 1999. [7]P.Milos, "La gestion del cuidado en la legislacion Chilena interpretacion y alcance", Cienc. Enfermería, vol. XVI, nº 1, pp. 17-29, 2010. [8]J.Valdebenito, "Gestión de cuidado: valoración y conocimientos de enfermeros/as de un hospital de la region metropolitana de Chile",Cienc. enf., vol. 21, nº 01, pp. 5-25, 2015. [9]S.Estefa y J. Paravic, "Enfermería en el rol de gestora de los cuidados",Cienc. Enferm., vol. 16, nº 3, pp. 3-39, 2010. [10]B. Scalzi y B. Mowinski, "Diffeferentiating nursing leadersip and management competensies", Nurs outlook, vol. 55, nº 1, pp. 169-175, 2007. [11]H.Koontz y H. Weihrieh, "Introducción a la administración" de Administración una perspectiva global, Mexico, Interamericana Editores, 2016, pp. 15-36. [12]L.Daderian y C. Arndt, "Breve historia de la teoria de la administración y su aplicación en la enfermería" de Administración de enfermería teoria para la práctica con un enfoque de sistema, California, Copyrignt, 2017, pp. 3-4. [13]N.Hernandez, "Administración de servicios sanitarios",2014. [En línea]. Available: ciniorte. [Último acceso: 23 07 2020]. [14]Z.Vargas, A. Espinosa, M. Lamadrid y M. Saavedra, "El desempeño de los profesionales de Enfermería", Rev.Cubana de Enfermería, vol. 3, nº 1, Recuperado de: http://www.revenfermeria.sld.cu/index.php/enf/article/view/823/155, 2016. [15]M.Loreto y L. Soler, Gestion y administración de servicios de enfermería, España, 2019. [16]C. Gonzalez, N. Barahona, M. Estrada, A. Favela y F. Cuen, "Evaluación de competencias del profesional de enfermería que labora en hospitales públicos y privado", Rev. Elec. Enfermería Actual en Costa Rica , vol. 27, pp. 9-15, 2016. [17]C. Fernandez, C. López y M. Sánchez, "La gestión del cuidado en la atencion primaria en salud Chile",Rev. iberoam.Educ. investi. Enferm, vol. 8, nº 2, pp. 18-29, 2018. [18]J.A.Riera, Gestion de cuidados enfermeros, Catalunya: Universidad Oberta de Catlunya, 2014. [19]F.Aguayo y R. Moraga, "Significado práctico del concepto gestión del cuidado en las enfermeras/os que se desempeñan en atención primaria en salud,"Cienc.enferm., vol. 21, nº 3, pp. 73-85, 2016. [20]N.Febres y V. Baldilla, "Calidad en enfermería su gestión implementación y medicion", Revista Medica Clinica los Condes, vol. 25,n° 2, pp. 278-287, 2016. [21]J.R. Beltran, "Gestión de enfermeria y el comportamiento de indicadores de calidad de atención de enfermería,» Revista Médica Clínica Las Condes, vol. 29, nº 3, pp. 269-276, 2018. [22]S.Martínez, F. Gómez y M. Lara, "El desempeño de los profesionales de enfermería", Revista cubana de enfermería, vol. 32, nº 1, pp. 98-108, 2016. [23]A.Hernández, "La gestion del cuidado",Revista Enfermería CyL, vol. 7, nº 2, pp. 19-26, 2014. [24]M.Lavalle y M. Villadiego, "La administración de enfermería en el area clinica y sus implicaciones en el cuidado," Revista colombiana de enfermería, vol. 9, nº 64, pp. 14-23, 2016. [25]M.Silveira y M. Galan, "Administración del cuidado concordancia entre prescripción de enfermería y necesidades de cuidados en los pacientes", Rlae, vol. 24:e2723., doi.org/10.1590/1518-8345.0645.2723 , 2016.

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Foran, James M., Theresa H. Keegan, Christina A. Clarke und Sandra J. Horning. „The Impact of Race and Socioeconomic Status (SES) on Survival in Non-Hodgkin’s Lymphoma (NHL): A Population-Based Study from the California Cancer Registry (CCR).“ Blood 110, Nr. 11 (16.11.2007): 3580. http://dx.doi.org/10.1182/blood.v110.11.3580.3580.

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Abstract Background: Despite the existence of well-established clinical prognostic indices for diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL), the 2 most common subtypes of NHL, significant heterogeneity in survival remains even within prognostic groups. SES has not previously been evaluated as a prognostic factor for NHL, particularly using an unselected patient population. We therefore used the large multiethnic CCR to examine NHL survival according to histology, race/ethnicity and neighborhood SES. Methods: NHL pts were identified from the CCR for the period 1988–97 using standardized ICD-0-3 classifications (morphology codes 9690–99 for FL & 9680–84 for DLBCL). Patients with evidence of HIV/AIDS were excluded. Neighborhood SES was assigned based on the address of residence at diagnosis, according to 1990 US Census Bureau census block group (each block contains about 1500 residents), and is based upon principal components of 7 indicator variables of SES (education level, proportion with blue collar job, proportion unemployed, median household income, proportion below 200% of poverty line, median rent & median home value). Using this index, we assigned each patient into an SES quintile (SES-1 lowest, SES-5 highest) based on the statewide distribution of neighborhood SES. We computed 5-year relative survival ± standard error (SE) with SEER*Stat software using customized race and SES-specific life tables based on US Census Bureau estimates for California residents. Results: Unselected DLBCL pts [n=13,604; comprising 73% non-Hispanic White (W), 4% Black (B), 14% Hispanic (H), 8% Asian/Pacific Islander (A)] & FL pts (n=7372; 82% W, 3% B, 11% H, 4% A) were identified. The overall 5 yr relative survival for DLBCL was 45.5% (SE 0.5) and for FL was 71.1% (SE 0.6); females had a better survival than males for DLBCL [F 48.3% (SE 0.7) vs. M 42.3% (SE 0.6)] but not for FL. Lower SES was associated with inferior survival for both DLBCL & FL (Table 1). Within SES groups there were not significant racial/ethnic differences in survival. However, in DLBCL, B (34%) and H (33%) pts were proportionally more likely to be in SES-1 than W (9%) or A pts (15%), and less likely to be in SES-5 (9% B, 10% H) than W (27%) or A (22%) pts. Similarly, in FL, B (39%) & H (26%) pts were also more likely than W (8%) & A (10%) pts to be in SES-1 and less likely to be in SES-5 (W-29%, A-32%, B-10%, H-11%). Conclusion: SES predicts survival in DLBCL and FL. Race/ethnicity differences in SES distribution are apparent in NHL patients, but when stratified by SES, race/ethnicity does not appear to predict for significant differences in NHL survival. 5 Year Relative Survival in DLBCL & FL by SES & Race SES-1 (%) SE (%) n SES-5 (%) SE (%) n W-non-Hispanic White; A-Asian/Pacific Islander; B-Black; H-Hispanic DLBCL 40.6 1.3 1905 49.4 1.0 3192 W 38.4 1.9 915 49.4 1.1 2701 A 44.0 4.2 168 48.2 3.5 244 B 45.0 4.2 185 54.3 7.3 51 H 41.6 2.1 637 48.9 4.0 196 FL 66.4 2.1 823 76.6 1.2 1959 W 66.3 2.7 502 77.1 1.2 1753 A 65.4 10.0 30 72.0 5.0 93 B 69.1 6.5 85 76.1 10.0 22 H 65.9 3.8 206 71.8 5.4 91

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Lu, Dan, Hua He, Bin Wu und Shanjing Yao. „Cytotoxic Effect on Cancer Cells and Structural Identification of Phenols from Spatholobi Caulis by HPLC-ESI-MSn“. Natural Product Communications 4, Nr. 6 (Juni 2009): 1934578X0900400. http://dx.doi.org/10.1177/1934578x0900400614.

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To find fractions from Spatholobi caulis with cytotoxic effects on cancer cell lines, screening tests were carried out using the SRB assay on the HL60 cell line. Further investigation with HL60 and another four human cancer cell lines (KB, K562, MCF-7 and Hep G2), revealed a dose-dependent response. High-performance liquid chromatography coupled with electrospray ionization-tandem mass spectrometry (HPLC- ESI-MSn) was used to isolate and identify the active constituents from the active fraction. Three fractions (F-IV, F-V and F-VII) showed in vitro cytotoxicity. F-V inhibited the growth of cancer cells in a dose-dependent manner. The IC50 values for KB, K562 and HL60 cells were 17.6, 8.3 and 9.7 μg/mL, respectively. The dominating constituents of F-V were either identified or tentatively characterized as nine phenolic compounds, eight isoflavones and 9-methoxycoumestrol. The isoflavones 7-hydroxy-3′,4′-dimethoxy isoflavone, 7-hydroxy-6,2′,4′-trimethoxy isoflavone and 3′-hydroxy-7,4′-dimethoxy isoflavone are reported for the first time for Spatholobi caulis. The results suggest that these compounds contribute to the cytotoxic effect of Spatholobi caulis.

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PAI, Chih-Hung, Kuo-Min KO und Troy SANTOS. „A Study of the Effect of Service Recovery on Customer Loyalty Based On Marketing Word Of Mouth in Tourism Industry“. Revista de Cercetare si Interventie Sociala 64 (06.03.2019): 74–84. http://dx.doi.org/10.33788/rcis.64.6.

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Akamavi, R K., Mohamed, E., Pellmann, K., & Xu, Y. (2015). Key determinants of passenger loyalty in the low-cost airline business. Tourism Management, 46, 528-545. Baldus, B.J., Voorhees, C., & Calantone, R. (2015). Online brand community engagement: Scale development and validation. Journal of Business Research, 68(5), 978-985. Boo, H.V. (2017). Service Environment of Restaurants: Findings from the youth customers. Journal of Asian Behavioural Studies, 2(2), 67-77. Bowen, T.J., & Chen, S.L. (2015). Transitioning Loyalty Programs: A Commentary on the Relationship Between Customer Loyalty & Customer Satisfaction. International Journal of Contemporary Hospitality Management, 27(3), 415-430. Casidy, R., & Shin, H. (2015). The effects of harm directions and service recovery strategies on customer forgiveness and negative word-of-mouth intentions. Journal of Retailing and Consumer Services, 27, 103-112. Chang, J.H. (2017). The role of relationship on time and monetary compensation. The Service Industries Journal, 37, 915-935. Fan, A., Mattila, A.S., & Zhao, X. (2015). How does social distance impact customers’ complaint intentions? A cross-cultural examination. International Journal of Health Policy and Management, 47, 35-42. Gohary, A., Hamzelu, B., & Alizadeh, H. (2016). Please explain why it happened! How perceived justice and customer involvement affect post co-recovery evaluations: a study of Iranian online shoppers. Journal of Retailing and Consumer Services, 31, 127-142. Guo, L., Lotz, S.L., Tang, C., & Gruen, T.W. (2015). The role of perceived control in customer value cocreation and service recovery evaluation. Journal of Service Research, 19(1), 39-56. Heidenreich, S., Wittkowski, K., Handrich, M., & Falk, T. (2015). The dark side of customer co-creation: exploring the consequences of failed co-created services. The Journal of the Academy of Marketing Science, 43(3), 279-296. Hsu, C.L., & Lin, J.C.C. (2016). Effect of perceived value and social influences onmobile app stickiness and in-app purchase intention.Technological Forecasting and Social Change, 108, 42-53. Kashif, M., Zarkada, A., & Ramayah, T. (2016).The impact of attitude, subjective norms, and perceived behavioural control on managers’ intentions to behave ethically. Total Quality Management & Business Excellence, 29(5-6), 1-21. Li, M., Qiu, S.C., & Liu, Z., (2016). The Chinese way of response to hospitality service failure: The effects of face and guanxi. International Journal Hospital Management, 57, 18-29. Liu, S.Q., & Mattila, A.S. (2015). “I Want to Help” versus “I Am Just Mad” how affective commitment influences customer feedback decisions. Cornell Hospitality Quarterly, 56(2), 213-222. Oman, B., Pepur, M., & Arneric, J. (2016). The impact of service quality and sport-team identification on the repurchase intention. Journal of Contemporary Management Issues, 21(1), 19-46. Ozuem, W., Patel, A., Howell, K.E. & Lancaster, G. (2016). An Exploration of Consumers' Response to Online Service Recovery Initiatives. International Journal of Market Research, 59(1), 97-115. Park, J., & Ha, S. (2016). Co-creation of service recovery: Utilitarian and hedonic value and post-recovery responses. Journal of Retailing and Consumer Services, 28, 310-316. Rezaei, S., Shahijan, M.K., Amin, M., & Ismail, W.K.W. (2016). Determinants ofapp stores continuance behavior: A pls path modellingapproach. Journal of Internet Commerce, 15(4), 408-440. Sengupta, S.A., Balaji, M., & Krishnan, B.C. (2015). How customers cope with service failure? A study of brand reputation and customer satisfaction. Journal of Business Research, 68(3), 665-674. Sloan, S., Bodey, K., & Gyrd-Jones, R. (2015). Knowledge sharing in online brand communities. Qualitative Market Research: An International Journal, 18(3), 320-345. Tan, C., Benbasat, I. & Cenfetelli, R.T. (2016). An Exploratory Study of the Formation and Impact of Electronic Service Failures. MIS Quarterly, 40(1), 1-31. Van Vaerenbergh, Y., & Orsingher, C. (2016). Service Recovery: An Integrative Framework and Research Agenda. The Academy of Management Perspectives, 30(3), 328-346. Varela, J.C.S., Svensson, G., Brambilla, F.R., & Oliveros, M.E.G. (2015) Perceived Justice & Emotions in a Negative Service Encounter: A Latin American Perspective. In: Kubacki K. (eds). Ideas in Marketing: Finding the New and Polishing the Old. Developments in Marketing Science: Proceedings of the Academy of Marketing Science. Cham: Springer. Vyas, V. & Raitani, S. (2015). A Study of the Impact of Relationship Marketing on Cross-Buying. Journal of Relationship Marketing, 14(2), 79-108. Weber, K., Sparks, B., & Hsu, C.H. (2016). The effects of acculturation, social distinctiveness, and social presence in a service failure situation. International Journal Hospital Management, 56, 44-55. Wu, J., Huang, L., Zhao, J.L., & Hua, Z. (2015).The deeper, the better? Effect of online brand community activity on customer purchase frequency. Information & Management, 52(7), 813-823. Yang, A., Chen, Y., & Huang, Y. (2017). Enhancing customer loyalty in tourism services: the role of customer-company identification and customer participation. Asia Pacific Journal of Tourism Research, 22(7), 735-746. Zhang, H., Zhang, K.Z., Lee, M.K., & Feng, F. (2015). Brand loyalty in enterprise microblogs: Influence of community commitment, IT habit, and participation. Information Technology & People, 28(2), 304-326.

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Xu, Hui, Qin Wang und Wen-Bin Yang. „Antifungal Activities of Some Indole Derivatives“. Zeitschrift für Naturforschung C 65, Nr. 7-8 (01.08.2010): 437–39. http://dx.doi.org/10.1515/znc-2010-7-803.

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Nine indole derivatives were evaluated in vitro against Fusarium graminearum, Alternaria alternata, Helminthosporium sorokinianum, Pyricularia oryzae, Fusarium oxysporum f. sp. vasinfectum, Fusarium oxysporum f. sp. cucumarinum, and Alternaria brassicae. Most of the compounds were found to possess antifungal activities. Especially compounds 2, 5, 8, and 9 exhibited broad-spectrum antifungal activities against the above-mentioned seven phytopathogenic fungi, and showed more potent activities than hymexazole, a commercial agricultural fungicide.

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Evers, Helen K. „Jaber F. Gubrium and Andrea Sankar (eds), The Home Care Experience, Sage, London, 1990, 280 pp., hbk no price, ISBN 0 803 93527 7, pbk no price, ISBN 0 803 93528 5.“ Ageing and Society 11, Nr. 3 (September 1991): 364–66. http://dx.doi.org/10.1017/s0144686x0000430x.

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Lilly, M., J. P. Rheeder, R. H. Proctor und W. C. A. Gelderblom. „FUM gene expression and variation in fumonisin production of clonal isolates of Fusarium verticillioides MRC 826“. World Mycotoxin Journal 14, Nr. 2 (12.04.2021): 121–37. http://dx.doi.org/10.3920/wmj2020.2626.

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B-series fumonisins (FBs) are a family of carcinogenic mycotoxins that commonly occur in maize. These mycotoxins cause multiple diseases in animals and are epidemiologically associated with several human diseases in populations for which maize is a dietary staple. FBs are produced by multiple genera of the fungi Aspergillus, Fusarium and Tolypocladium, but the plant pathogen Fusarium verticillioides is considered the primary cause of FB contamination in maize. One F. verticillioides strain, MRC 826, is reported to produce high levels of FBs. However, in the current study, 18 isolates derived from strain MRC 826 exhibited highly variable levels of FB, which negatively correlated (r=-0.333; P<0.008) with fungal growth. Microsatellite analysis confirmed that all MRC 826 derived isolates examined were clonal, and 100% DNA sequence identity was observed across the FUM gene clusters of two high FB producing and two low FB producing isolates. At the gene expression level, qRT-PCR at each time point (7, 14, 21 and 28 days of incubation) showed differential upregulation of selected FUM genes in the high compared to the low FB isolates. Variation in FB production appears due to differences in FUM gene expression, most likely caused by sequence differences at unexamined loci not part of the FUM cluster or from epigenetic influences. Clarification of the genetic/epigenetic basis for quantitative differences in fumonisin production among strains and isolates of F. verticillioides has potential to reveal targets for reducing FB contamination in maize.

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Suryana, Dadan, Fitriana Sari Khairma, Novi Engla Sari, Lina, Farida Mayar und Sri Satria. „Star of The Week Programs Based on Peer Relationship for Children Social Emotional Development“. JPUD - Jurnal Pendidikan Usia Dini 14, Nr. 2 (30.11.2020): 288–302. http://dx.doi.org/10.21009/jpud.142.07.

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The influence of family, school and peers on students' emotional social development is very important as a starting point for the design of school activities that will also improve student development in an integral way. The Star of the Week program was developed with the aim of helping students apply the knowledge, attitudes, and skills needed to socialize and understand and manage emotions. This study uses the Thiagarajan model stages, namely define, design, develop, and disseminate (4D). The results of the validity test from the experts show that this program has workable value with 91.1% material aspects, 90% emotional development aspects and 92% presentation aspects. For the practicality test results through teacher questionnaires obtained scores of 90%, and 88.67% through teacher observations of children who are in the high practical category. The results of the program effectiveness test showed a value of 89.08% on children's social-emotional development, because it showed an increase in values before and after the intervention. The implication of further research is that it is hoped that various kinds of learning methods will develop aspects of child development based on cooperation and peer relationships. Keywords: Early Childhood, Peer Relationships, Star of the Week Program, Social Emotional References Acar, I. H., Hong, S. Y., & Wu, C. R. (2017). Examining the role of teacher presence and scaffolding in preschoolers’ peer interactions. European Early Childhood Education Research Journal, 25(6), 866–884. https://doi.org/10.1080/1350293X.2017.1380884 Acar, I. H., Rudasill, K. M., Molfese, V., Torquati, J., & Prokasky, A. (2015). Temperament and preschool children’s peer interactions. Early Education and Development, 26(4), 479–495. https://doi.org/10.1080/10409289.2015.1000718 Akhir, K., & Wisz, M. S. (2018). Sustainostic Nusantara : Managing marine plastic debris for sustainable tourism in the ‘ New Bali ’ of Indonesia (4.0). https://doi.org/https://doi.org/10.7287/peerj.preprints.26747v1 | Alwaely, S. A., Yousif, N. B. A., & Mikhaylov, A. (2020). Emotional development in preschoolers and socialization. Early Child Development and Care, 0(0), 1–10. https://doi.org/10.1080/03004430.2020.1717480 Asher, S. R., & Parker, J. G. (1989). Significance of Peer Relationship Problems in Childhood. In Social Competence in Developmental Perspective, 5–23. https://doi.org/https://doi.org/10.1007/978-94-009-2442-0_1 Beazidou, E., & Botsoglou, K. (2016). Peer acceptance and friendship in early childhood: the conceptual distinctions between them. Early Child Development and Care, 186(10), 1615–1631. https://doi.org/10.1080/03004430.2015.1117077 Blazevic, I. (2016). Family, Peer and School Influence on Children’s Social Development. World Journal of Education, 6(2), 42–49. https://doi.org/10.5430/wje.v6n2p42 Chung, K. K. H., Lam, C. B., & Liew, J. (2020). Studying Children’s Social-Emotional Development in School and at Home through a Cultural Lens. Early Education and Development, 31(6), 927–929. https://doi.org/10.1080/10409289.2020.1782860 Coelho, L., Torres, N., Fernandes, C., & Santos, A. J. (2017). Quality of play, social acceptance and reciprocal friendship in preschool children. European Early Childhood Education Research Journal, 25(6), 812–823. https://doi.org/10.1080/1350293X.2017.1380879 Conti-Ramsden, G., Mok, P., Durkin, K., Pickles, A., Toseeb, U., & Botting, N. (2019). Do emotional difficulties and peer problems occur together from childhood to adolescence? The case of children with a history of developmental language disorder (DLD). European Child and Adolescent Psychiatry, 28(7), 993–1004. https://doi.org/10.1007/s00787-018-1261-6 Di Maggio, R., Zappulla, C., Pace, U., & Izard, C. E. (2017). Adopting the Emotions Course in the Italian Context: A Pilot Study to Test Effects on Social-Emotional Competence in Preschool Children. Child Indicators Research, 10(2), 571–590. https://doi.org/10.1007/s12187-016-9387-x Domitrovich, C. E., Staley, K. C., Durlak, J. A., & Weissberg, R. P. (2017). Social-Emotional Competence : An Essential Factor for Promoting Positive Adjustment and Reducing Risk in School Children Social-Emotional Competence : An Essential Factor for Promoting Positive Adjustment and Reducing Risk in School Children. Child Development, 1–9. Durlak, J. A., Weissberg, R. P., Dymnicki, A. B., Taylor, R. D., & Schellinger, K. B. (2011). The Impact of Enhancing Students’ Social and Emotional Learning: A Meta-Analysis of School-Based Universal Interventions. Child Development, 82(1), 405–432. https://doi.org/10.1111/j.1467-8624.2010.01564.x Elias, M. J., & Haynes, N. M. (2008). Social Competence, Social Support, and Academic Achievement in Minority, Low-Income, Urban Elementary School Children. School Psychology Quarterly, 23(4), 474–495. https://doi.org/10.1037/1045-3830.23.4.474 Fajriyah, L. (2018). Pengembangan Literasi Emergen Pada Anak Usia Dini. Proceedings of the ICECRS, 165–172. https://doi.org/https://doi.org/10.21070/picecrs.v1i3.1394 Forrest, C. L., Gibson, J. L., Halligan, S. L., & St Clair, M. C. (2018). A longitudinal analysis of early language difficulty and peer problems on later emotional difficulties in adolescence: Evidence from the Millennium Cohort Study. Autism & Developmental Language Impairments, 3, 239694151879539. https://doi.org/10.1177/2396941518795392 Hartup, W. W. (1992). Peer Relations in Early and Middle Childhood. https://doi.org/https://doi.org/10.1007/978-1-4899-0694-6_11 Hernández, Y. C. U., Núñez, E. F. D., Inga-Arias, M., & Lozada, O. R. (2020). Early stimulation and emotional intelligence and its incidence in communication learning at the initial level. International Journal of Early Childhood Special Education,12(1), 433–441. https://doi.org/10.9756/INT-JECSE/V12I1.201023 Khoiruddin, M. A. (2018). Perkembangan Anak Ditinjau dari Kemampuan Sosial Emosional. Jurnal Pemikiran Keislaman, 29(2), 425–438. https://doi.org/https://doi.org/10.33367/tribakti.v29i2.624 Kim, J., & Cicchetti, D. (2010). Longitudinal pathways linking child maltreatment, emotion regulation. J Child Psychol Psychiatry, 51(6), 706–716. https://doi.org/10.1111/j.1469-7610.2009.02202.x.Longitudinal Kompri. (2016). Motivasi Pembelajaran Perspektif Guru dan Siswa. PT Remaja Rosdakarya. Krauthamer Ewing, E. S., Herres, J., Dilks, K. E., Rahim, F., & Trentacosta, C. J. (2019). Understanding of Emotions and Empathy: Predictors of Positive Parenting with Preschoolers in Economically Stressed Families. Journal of Child and Family Studies, 28(5), 1346–1358. https://doi.org/10.1007/s10826-018-01303-6 Lane, J. D., & Shepley, C. (2019). Research to Practice: Promoting Academic and Social Behaviors in a Small Group. Journal of Early Intervention, 41(4), 279–282. https://doi.org/10.1177/1053815116643833 Lojk, M., & Adolfsson, M. (2017). Promoting peer interactions of preschool children with behavior problems A Systematic Literature Review. Magdalena, S. M. (2013). Social and emotional competence - predictors of school adjustment. Procedia - Social and Behavioral Sciences, 76, 29–33. https://doi.org/10.1016/j.sbspro.2013.04.068 Maslow, A. (1984). Motivasi dan Kepribadian: Teori Motivasi dengan Ancangar Hirarki Kebutuhan Manusia. Gramedia Pustaka Utama. Mayar, F. (2013). Perkembangan Sosial Anak Usia Dini Sebagai Bibit Untuk Masa Depan Bangsa. AL-Ta Lim, 20(3), 459–464. https://doi.org/https://doi.org/10.15548/jt.v20i3.43 McCormac, M. E., & Snyder, S. (2019). Districtwide Initiative to Improve Tier 1 With Evidence-Based Classroom Lessons. Professional School Counseling, 22(1b), 2156759X1983443. https://doi.org/10.1177/2156759x19834438 Moberly, D. A., Waddle, J. L., & Duff, R. E. (2014). Journal of Early Childhood Teacher Education The use of rewards and punishment in early childhood classrooms The use of rewards and punishment in early childhood classrooms. Journal of Early Childhood Teacher Education, 37–41. https://doi.org/10.1080/1090102050250410 Moore, J. E., Cooper, B. R., Domitrovich, C. E., Morgan, N. R., Cleveland, M. J., Shah, H., Jacobson, L., & Greenberg, M. T. (2015). The effects of exposure to an enhanced preschool program on the social-emotional functioning of at-risk children. Early Childhood Research Quarterly, 32, 127–138. https://doi.org/10.1016/j.ecresq.2015.03.004 Morris, A. S., & Williamson, A. C. (2019). Building early social and emotional relationships with infants and toddlers: Integrating research and practice. Building Early Social and Emotional Relationships with Infants and Toddlers: Integrating Research and Practice, 1–351. https://doi.org/10.1007/978-3-030-03110-7 Morrison, G. S. (2012). Dasar-dasar Pendidikan Anak Usia Dini (PAUD). Indeks. Nix, R. L., Bierman, K. L., Domitrovich, C. E., & Gill, S. (2013). Promoting Children’s Social-Emotional Skills in Preschool Can Enhance Academic and Behavioral Functioning in Kindergarten: Findings from Head Start REDI. Early Educ Dev, 24(7), 1–7. https://doi.org/10.1080/10409289.2013.825565.Promoting Nurmalitasari, F. (2015). Perkembangan Sosial Emosi pada Anak Usia Prasekolah. Buletin Psikologi, 23(2), 103. https://doi.org/https://doi.org/10.22146/bpsi.10567 Ramani, G. B., Brownell, C. A., & Campbell, S. B. (2010). Positive and negative peer interaction in 3- and 4-year-olds in relation to regulation and dysregulation. In Journal of Genetic Psychology (Vol. 171, Issue 3). https://doi.org/10.1080/00221320903300353 Santrock, J. W. (2012). Perkembangan Masa Hidup. Erlangga. Shearer, R. J. B., Domínguez, X., Ell, E. R., Rouse, H. L., & Fantuzzo, J. W. (2010). Relation Between Behavioral Disorders Problems in Classroom Social and Learning Situations and Peer Social Competence in Head Start and kindergarten. Journal of Emotional and Behavioral Disorders, 18(4), 195–210. https://doi.org/https://doi.org/10.1177/1063426609351172 Uslu, F., & Gizir, S. (2017). School belonging of adolescents: The role of teacher–student relationships, peer relationships and family involvement. Kuram ve Uygulamada Egitim Bilimleri, 17(1), 63–82. https://doi.org/10.12738/estp.2017.1.0104 Wang, C., Hatzigianni, M., Shahaeian, A., Murray, E., & Harrison, L. J. (2016). The combined effects of teacher-child and peer relationships on children’s social-emotional adjustment. Journal of School Psychology, 59, 1–11. https://doi.org/10.1016/j.jsp.2016.09.003 Wang, Y., Palonen, T., Hurme, T. R., & Kinos, J. (2019). Do you want to play with me today? Friendship stability among preschool children. European Early Childhood Education Research Journal, 27(2), 170–184. https://doi.org/10.1080/1350293X.2019.1579545 Watanabe, N., Denham, S. A., Jones, N. M., Kobayashi, T., Bassett, H. H., & Ferrier, D. E. (2019). Working Toward Cross-Cultural Adaptation: Preliminary Psychometric Evaluation of the Affect Knowledge Test in Japanese Preschoolers. SAGE Open, 9(2), 2–4. https://doi.org/10.1177/2158244019846688 Westrupp, E. M., Reilly, S., McKean, C., Law, J., Mensah, F., & Nicholson, J. M. (2020). Vocabulary Development and Trajectories of Behavioral and Emotional Difficulties Via Academic Ability and Peer Problems. Child Development, 91(2), e365–e382. https://doi.org/10.1111/cdev.13219 Wilson, L. M., & Corpus, D. A. (2001). The Effects of Reward Systems on Academic Performance. Middle School Journal, 33(1), 56–60. https://doi.org/10.1080/00940771.2001.11495578 Yang, W., Datu, J. A. D., Lin, X., Lau, M. M., & Li, H. (2019). Can Early Childhood Curriculum Enhance Social-Emotional Competence in Low-Income Children? A Meta-Analysis of the Educational Effects. Early Education and Development,30(1), 36–59. https://doi.org/10.1080/10409289.2018.1539557

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Bachir, Dora, Anoosha Habibi, Serge Pissard, Zohra Ourabah und Frederic Galacteros. „Treatment with rhEPO Decreases the Need for Transfusion in Patients with βThalassemia.“ Blood 104, Nr. 11 (16.11.2004): 3778. http://dx.doi.org/10.1182/blood.v104.11.3778.3778.

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Abstract The usage of human recombinant erythropoietin (rhEPO) in βthalassemia shows in many sudies, that not only it increases the synthesis of γ chains, but it also improves erythroid parameters. Among our population of thalassemic patients, eight patients with βthalassemia intermedia that were regulary transfused, were given escalating doses of rhEPO mostly darpoietin-α. Before receiving rhEPO, all patients had undergone splenectomy, also received iron chelation therapy, and folic acid supplementation. No patient received iron supplementation together with rhEPO. With rhEPO, two patients were able to discontinue their requirements for transfusions. In the others, haemoglobin level was maintained above 8 g/dl. Four patients experienced bone pain which was successfully treated with hydroxyurea. All patients had improvement in their quality of life. This small series illustrates that rhEPO may be useful and cost effective in the long term (considering the risks of red blood cell transfusion) in some selected splenectomized transfusion-dependent patients with βthalassemia intermedia. Results Transfusion requirements (ml/kg/year) Patients Year of birth Sex Final doses of rhEPO (UI*kg/week) Follow-up (months) Before After Hydroxyurea * interruption of rhEPO because of participation to ICL 670 A 0107 protocol 1 1975 M 970 33 150 75 + 2 1973 F 1365 34 125 0 + 3 1965 M 820 33 130 0 + 4 1959 F 650 27 125 98 + 5 1979 F 715 15 210 160 * + 6 1978 M 1035 7 255 90 − 7 1987 F 450 3 135 80 − 8 1974 M 900 7 190 75 +

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Jain, Manu. „Electron Spin Resonance Of Vo2+ In Likso4 Single Crystals“. Zeitschrift für Naturforschung A 59, Nr. 7-8 (01.08.2004): 488–90. http://dx.doi.org/10.1515/zna-2004-7-813.

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Electron spin resonance of VO2+ doped in LiKSO4 single crystals has been studied at 295 K, using an X-band spectrometer. Three sites have been observed. VO2+ enters the lattice at Li and K substitutional sites. The ESR spectra have been analysed and spin-Hamiltonian parameters evaluated. PACS: 76.30 F

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Hiramatsu, Daichi, Edo Berger, Brian D. Metzger, Sebastian Gomez, Allyson Bieryla, Iair Arcavi, D. Andrew Howell, Ryan Mckinven und Nozomu Tominaga. „Limits on Simultaneous and Delayed Optical Emission from Well-localized Fast Radio Bursts“. Astrophysical Journal Letters 947, Nr. 2 (01.04.2023): L28. http://dx.doi.org/10.3847/2041-8213/acae98.

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Abstract We present the largest compilation to date of optical observations during and following fast radio bursts (FRBs). The data set includes our dedicated simultaneous and follow-up observations, as well as serendipitous archival survey observations, for a sample of 15 well-localized FRBs: eight repeating and seven one-off sources. Our simultaneous (and nearly simultaneous with a 0.4 s delay) optical observations of 13 (1) bursts from the repeating FRB 20220912A provide the deepest such limits to date for any extragalactic FRB, reaching a luminosity limit of ν L ν ≲ 1042 erg s−1 (≲2 × 1041 erg s−1) with 15–400 s exposures; an optical-flux-to-radio-fluence ratio of f opt/F radio ≲ 10−7 ms−1 (≲10−8 ms−1); and a flux ratio of f opt/f radio ≲ 0.02–≲2 × 10−5 (≲10−6) on millisecond to second timescales. These simultaneous limits provide useful constraints in the context of FRB emission models, such as the pulsar magnetosphere and pulsar nebula models. Interpreting all available optical limits in the context of the synchrotron maser model, we find that they constrain the flare energies to ≲1043–1049 erg (depending on the distances of the various repeating FRBs, with ≲1039 erg for the Galactic SGR 1935+2154). These limits are generally at least an order of magnitude larger than those inferred from the FRBs themselves, although in the case of FRB 20220912A our simultaneous and rapid follow-up observations severely restrict the model parameter space. We conclude by exploring the potential of future simultaneous and rapid-response observations with large optical telescopes.

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Heintz, K. E., P. A. Oesch, M. Aravena, R. J. Bouwens, P. Dayal, A. Ferrara, Y. Fudamoto et al. „The ALMA REBELS Survey: The Cosmic H i Gas Mass Density in Galaxies at z ≈ 7“. Astrophysical Journal Letters 934, Nr. 2 (01.08.2022): L27. http://dx.doi.org/10.3847/2041-8213/ac8057.

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Abstract The neutral atomic gas content of individual galaxies at large cosmological distances has until recently been difficult to measure due to the weakness of the hyperfine H i 21 cm transition. Here we estimate the H i gas mass of a sample of main-sequence star-forming galaxies at z ∼ 6.5–7.8 surveyed for [C ii] 158 μm emission as part of the Reionization Era Bright Emission Line Survey (REBELS), using a recent calibration of the [C ii]-to-H i conversion factor. We find that the H i gas mass excess in galaxies increases as a function of redshift, with an average of M Hi /M ⋆ ≈ 10, corresponding to H i gas mass fractions of f Hi = M Hi /(M ⋆ + M Hi ) = 90%, at z ≈ 7. Based on the [C ii] 158 μm luminosity function (LF) derived from the same sample of galaxies, we further place constraints on the cosmic H i gas mass density in galaxies (ρ Hi ) at this redshift, which we measure to be ρ H I = 7.1 − 3.0 + 6.4 × 10 6 M ⊙ Mpc − 3 . This estimate is substantially lower by a factor of ≈10 than that inferred from an extrapolation of damped Lyα absorber (DLA) measurements and largely depends on the exact [C ii] LF adopted. However, we find this decrease in ρ Hi to be consistent with recent simulations and argue that this apparent discrepancy is likely a consequence of the DLA sight lines predominantly probing the substantial fraction of H i gas in high-z galactic halos, whereas [C ii] traces the H i in the ISM associated with star formation. We make predictions for this buildup of neutral gas in galaxies as a function of redshift, showing that at z ≳ 5, only ≈10% of the cosmic H i gas content is confined in galaxies and associated with the star-forming ISM.

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Adekile, Adekunle D., Ferdane Kutlar, Kathleen McKie, Anthony Addington, Dedrey Elam, Betsy Clair, Leslie Holley und Abdullah Kutlar. „The Influence of Uridine Diphosphate Glucuronosyl Transferase 1A Promoter Polymorphism, βS-Globin Gene Haplotype, Co-Inherited α-Thalassemia Trait and Hb F on Steady-State Serum Bilirubin Levels in Sickle Cell Anemia.“ Blood 104, Nr. 11 (16.11.2004): 1682. http://dx.doi.org/10.1182/blood.v104.11.1682.1682.

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Abstract The chronic hemolysis of sickle cell anemia (SCA) produces hyperbilirubinemia but serum bilirubin level varies considerably and the modulating factors have not been fully elucidated. One identified genetic factor is the uridine diphosphate glucuronosyl transferase 1A (UGT1A) gene promoter polymorphism in which homozygosity for the (AT)7 allele has been associated with increased bilirubin levels in children with SCA. The same association has been reported in apparently healthy individuals, in β-thalassemia, G6PD deficiency, neonatal jaundice and hereditary spherocytosis. In the present study, in addition to UGT1A promoter genotype, serum bilirubin level was related to other genetic modifiers - βS-globin gene haplotype, Hb F, co-inherited α-thal trait, age and gender. The patients were randomly selected from the sickle cell clinic, Medical College of Georgia. UGT1A promoter genotypes were determined using automated sequencing and spreadex gel electrophoresis. Other investigations were with standard techniques. There were 67 SCA patients (41 males, 26 females), aged 2 to 44 years (mean of 20.6±10.7). Ten (14.9%) patients were homozygous for the (AT)6 UGT1A allele, 22 (32.8%) were homozygous for the (AT)7, while 35 (52.2%) were heterozygous for the two. Serum bilirubin was significantly higher in the homozygous (AT)7 group (3.7±1.5, 5.6±2.4 and 3.8±2.3 mg/dl respectively). It was also significantly higher in males than females (4.9±2.7 vs 3.7±1.7 mg/dl) and highest in patients aged >10 years. Co-inherited α-thal trait did not significantly affect the levels. There was a significant negative linear correlation (r = −0.304, p=0.016) of serum bilirubin with Hb F. Hb F was also significantly higher among females than males and when the different age groups were compared, it was highest in those <10 years old. Apart from UGT1A (AT)7 homozygosity, Hb F significantly influences serum bilirubin level in steady-state SCA. This is probably mediated via its hemolysis-sparing effect. Our (AT)7 homozygotes, including both children and adults, had significantly higher mean serum bilirubin level as previously reported by others. Indeed, when only the adults were analyzed, there was a distinct trimodal distribution among the 6/6, 6/7 and 7/7 UGT1A genotypes with serum bilirubin levels of 3.9 ± 0.9, 4.9 ± 2.2 and 5.8 ± 2.5 mg/dl respectively. Among children (<10 years), this trimodal distribution is lost, which supports the premise that a high Hb F is probably more important in modulating serum bilirubin levels in this age group. Serum Bilirubin and Other Parameters Grouped According to UGT1A1 Genotype UGT1A1 Genotype Age (yrs) Hb (g/dl) Retics (%) Hb F (%) Bilirubin (mg/dl) 6/6 (n=10) 18.1±8.7 7.9±1.2 11.3±4.7 8.4±6.4 3.7±1.5 6/7 (n=35) 17.9±10.9 8.7±1.3 11.4±4.2 10.9±8.6 3.8±2.3 7/7 (n=22) 26.1±9.3 8.3±2.1 10.9±4.8 6.6±5.4 5.6±2.4

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Balansa, Walter, Lis C. Lukas, Frets J. Rieuwpassa und Aprelia M. Tomasoa. „Aktivitas Antibakteri Sponge Agelas Nakamurai Terhadap Bakteri Gram Negative: Study In Vitro dan In Silico“. Samakia : Jurnal Ilmu Perikanan 14, Nr. 1 (06.05.2023): 76–84. http://dx.doi.org/10.35316/jsapi.v14i1.3012.

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Bakteri gram negatif tetap menjadi ancaman serius bagi akuakultur, ekonomi, dan kesehatan manusia. Ironisnya, sementara antibiotik yang efektif belum ditemukan, resistensi bakteri ini terhadap berbagai antibiotik meningkat dengan kecepatan yang mengkhawatirkan. Hal ini menunjukkan urgensi penemuan antibiotik baru, terutama antibiotik yang dapat menghambat replikasi enzim seperti DNA gyrase atau topoisomerase IV, yang saat ini menjadi target baru penemuan antibiotik. Tujuan dari penelitian ini adalah untuk mengetahui potensi antibakteri Agelas nakamurai terhadap A. hydrophila, A. salmonicida dan E. tarda menggunakan ekstrak spons (1, 10, dan 100) mg/mL dan tetrasiklin (1 mg/mL) sebagai kontrol positif dan memprediksi potensi antibakteri dari agelasine A-F (1-6) dan agelasidine A (7) dari A. nakamurai dari Kepulauan Sangihe terhadap protein topoisomerase IV melalui docking molekuler. Uji in vitro dilakukan dengan menggunakan metode Kirby Bauer dengan sedikit modifikasi dan studi in silico menggunakan CB-dock 2 dan Protein Ligand Interaction Profiler. Meskipun ekstrak menunjukkan aktivitas antibakteri yang lebih lemah terhadap A. hydrophila, A. salmonicida dan E. tarda dibandingkan tetrasiklin, molekul docking dengan CB-dock 2 menunjukkan bahwa agelasine A-F (1-6) dan agelasidin A (7) memiliki afinitas pengikatan yang lebih kuat (-7.1). hingga -8,6 kJ/mol) daripada tetrasiklin (10), ciprofloksasin (11) atau levofloksasin (12) (-6,6 hingga -8,3 kJ/mol). Docking molekuler pada agelasidin C (9) dan D (10) juga menunjukkan afinitas pengikatan yang kuat (-8,3 dan -8,8 kJ/mol) ke protein target 1S16 terutama akibat ikatan hidrogen dan interaksi hidrofobik. Secara kolektif, hasil ini menunjukkan potensi agelasidin A, C dan D sebagai modulator dari target antibiotik baru, enzim topoisomerase IV.

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Gould, Dinah. „Media reviews. Clinical Genetics in Nursing Practice 2nd edition, by F. Lashley, Springer Publishing Company, New York, 1998, 552 pages, $79.00, ISBN 0 826 11177 7.“ Journal of Advanced Nursing 31, Nr. 4 (April 2000): 981–82. http://dx.doi.org/10.1046/j.1365-2648.2000.1399d.x.

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Stockert, J. C., C. I. Trigoso, A. Tato und J. M. Ferrer. „Electron Microscopical Morphology of Cytoplasmic Granules from Horse Eosinophil Leucocytes“. Zeitschrift für Naturforschung C 48, Nr. 7-8 (01.08.1993): 669–72. http://dx.doi.org/10.1515/znc-1993-7-822.

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The structure of specific granules from horse eosinophil leucocytes is still largely unknown. In this work, electron microscopical studies of horse eosinophils reveal that the large cytoplasmic granules contain an external membrane, a m atrix o f less density, and a dense (non crystalline) core. Round vacuolar inclusions of matrix materials were often observed within the cores. Horse eosinophil granules showed a considerable heterogeneity, and three morphological types could be identified according to structural features of the core and matrix.

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Zorgniotti, A. W. „Re: Physiology of Erection and Pharmacological Management of Impotence, by T. F. Lue and E. A. Tanagho, J. Urol., 137: 829–836, 1987“. Journal of Urology 139, Nr. 2 (Februar 1988): 387. http://dx.doi.org/10.1016/s0022-5347(17)42434-7.

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Garbarino, James, Robert John Zagar, Brad Randmark, Ishup Singh, Joseph Kovach, Emma Cenzon, Michael Benko, Steve Tippins, Kenneth G. Busch und Rohit Baghel. „16-Questions to Find Mass-Murderers, Spree-Shooters, Domestic-Terrorists, and a Study-1 of 232-School-Shooters with Controls and a Study-2 of 6-Teen-Shooters With 11-Homicidal and 12-Control Youth Rated with Ask Standard Predictor (ASP) of Violence Potential-Youth Version and the MMPI-A: Implications: Use Computer-Tests and Machine-Learning-Equations to Lower Insurance-Premiums and Prevent Church-Bankruptcy from Violent Offenses“. Review of European Studies 14, Nr. 2 (17.05.2022): 115. http://dx.doi.org/10.5539/res.v14n2p115.

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630 Domestic-Terrorist-Mass-Murdering-Spree-Shooters are compared with 623-controls and separated by16-Questions with significant a=.846, p<.01, AUC=.704, p<.01 that are: (1) homicidal? (2) suicidal? (3) stressful-life-event? (4) handgun-many-weapons-access? (5) violence-planning-preparing? (6) revenge-motive? (7) eliciting-others-concern? (8) intent-leakage? (9) criminal-misconduct-history? (10) personal-grievance? (11) random-violent-behavior? (12) threatening-victims? (13) dead-male-victim? (14) targeting-person-school-or-work? (15) student-professional-work-relationship? and (15) student? Before the killing, terrorists come twice to courts, doctors, schools and human resources and are not diagnosed as dangerous. In Study-1: [from 1936-2019] 232-school-shooters are contrasted with 232-controls resulting in 414-dead, 832-injured, and 68-suicides (29%) which are analyzed with logistic-regression, F= 227.14, p<.01, df=8/455, R=.894, p<.01, R2=.8, p<.01, and separated with 8-Questions: (1) student? (2) suicidal? (3) stressful-life-event? (4) homicidal? (5) violence-planning-preparing? (6) personal-grievance? (7) handgun-access? and (8) targeting-person(s)? In Study-2: 6-teen-shooters with 11-homicidal and 12-controls are contrasted with the Ask-Standard-Predictor [ASP] Violence-Potential, Youth-Version (54-questions, a=.61, p<.01, AUC=.91, p<.01, rtest-retest=.75, p<.01, F=123.09, p<.01, and the Minnesota Multiphasic Personality Inventory Adolescent Version [MMPI-A (468-questions):], ANOVA-F=17.22, p<.01, Lie, F=33.91, Depression, F=26.18, p<.01, Psychopathic-Deviate, F=57.45, p<.01,Paranoia, F=23.92, p<.01, Schizophrenia, F=21.69, p<.01, MacAndrews Alcohol, F=16.84, p<.01, Addiction Admission, F= 38.88, p<.01, resulting in a “7-point-violence-profile,”found over 95 yrs. in 212-studies .(N=320,051). The expense side includes 2 examples. 1st, School-shooter insurance-industry higher-premiums from (1936-2019) resulted in [414-dead @ $3,834,988.08=$1,587,685,065.12] + [832-injured @ $33,773.52=$28,099,568.64]+[232-shooters@$3,834,988.08=$889,717,234.60]+[$2,505,501,868.32x1.3= $3,257,152,428.82] =a high cost of $5,762,654,297.14]. With no-computer-tests-equations from 2020-2106, ($5,762,654,297.14x2= [the expense will double to] $11,525,308,594.27, 828-dead, 1,664-injured. The 2nd violence example is the U.S-Catholic-Church-pedophilia-loss, (1936-2107) [payouts, $17,435,353,000] + [lost-donations =1.3 x payouts=] 22,665,958,900=$40,101,511,900(1986-2107), with 5,679 victims increasing (1936-2107) to 39,753-victims.

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Riss, A. „Cradle of Liberty: Race, the Child, and National Belonging from Thomas Jefferson to W. E. B. Du Bois. By Caroline F. Levander. (Durham: Duke University Press, 2006. xii, 247 pp. Cloth, $74.95, ISBN 978-0-8223-3856-7. Paper, $21.95, ISBN 978-0-8223-3872-7.)“. Journal of American History 94, Nr. 2 (01.09.2007): 546–47. http://dx.doi.org/10.2307/25094984.

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LINE, J. ERIC, ALFRED R. FAIN, ALICE B. MORAN, L. MICHELE MARTIN, RICHARD V. LECHOWICH, JERRY M. CAROSELLA und WILLIAM L. BROWN. „Lethality of Heat to Escherichia coli 0157:H7: D-Value and Z-Value Determinations in Ground Beef“. Journal of Food Protection 54, Nr. 10 (01.10.1991): 762–66. http://dx.doi.org/10.4315/0362-028x-54.10.762.

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D-values and z-values were determined for lean (2.0% fat) and fatty (30.5% fat) ground beef inoculated with approximately 107 Escherichia coli 0157:H7 cells per g. Inoculated ground meat was sealed in glass thermal death time tubes which were completely immersed in a circulating water bath and held at prescribed temperatures for predetermined lengths of time. Survival was determined by enumeration on plate count agar (PCA) containing 1% sodium pyruvate and by the 2-h indole test of Lee and McClain (7). D-values for fatty ground beef exceeded those for lean ground beef at the temperatures tested. D-values for lean and fatty ground beef at 125°F were 78.2 and 115.5 min, respectively, as enumerated on PCA plus pyruvate. D-values at 135°F were 4.1 and 5.3 min for lean and fatty beef. At 145°F D-values were determined to be 0.3 and 0.5 min. D-values calculated from 2-h indole test data for lean and fatty ground beef at 125°F were 80.1 and 121.0 min, respectively. D-values at 135°F were 4.0 and 7.4 min for lean and fatty beef and at 145°F a D-value of 0.2 min was calculated for lean beef only, due to insufficient survival of E. coli 0157:H7 in fatty beef at this temperature. The z-values determined for lean beef and fatty beef using PCA were 8.3 and 8.4°F respectively. The z-value for lean beef using the 2-h indole data was 7.8°F. No z-value for fatty beef using 2-h indole data could be determined.

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Correa, Juan Gonzalo, Alberto Alvarez-Larrán, Monica Lopez-Guerra, Juan Carlos Hernandez Boluda, Mar Tormo, María Rozman, Daniel Martínez, Dolors Colomer, Jordi Esteve und Francisco Cervantes. „Triple Negative Myelofibrosis and Myelodysplastic Syndrome with Fibrosis: Clinico-Biological Characterization and Correlation with Gene Mutations“. Blood 132, Supplement 1 (29.11.2018): 4299. http://dx.doi.org/10.1182/blood-2018-99-115888.

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Abstract Introduction: Triple negative primary myelofibrosis (TN-PMF) and myelodysplastic syndromes with fibrosis (F-MDS) are rare entities, often difficult to distinguish each other. Currently, no specific molecular markers allowing a precise differential diagnosis are available. In this sense, next generation techniques (NGS) might be useful to distinguish between both entities and to refine prognosis. Methods: Thirty-nine patients with TN-PMF (n=16) or F-MDS (n=23) were analyzed, Targeted NGS was performed in 28 cases (10 TN-PMF and 18 F-MDS) using the Sophia Genetics Myeloid Tumor Solution Panel including the following genes: ABL1, ASXL1, BRAF, CALR, CBL,CEBPA, CSF3R,CSNK1A1,DNMT3A, ETV6, EZH2, FLT3,HRAS, IDH1, IDH2, JAK2, KIT, KMT2A, KRAS, MPL, NPM1, NRAS, PTPN11, RUNX1, SETBP1, SF3B1, SRSF2, TET2, TP53, U2AF1, U2AF2, WT1 and ZRSR2. High molecular risk (HMR) was defined by the presence of any mutation in ASXL1, SRSF2, EZH2 or IDH1/2 genes. Clinical and biological data at diagnosis were compared among both groups of patients, including bone marrow cytogenetics, bone marrow histology, and the results from NGS analysis. The probabilities of survival and progression to acute leukemia were estimated by the Kaplan Meier method using the log rank test for comparisons. Results: Median age at diagnosis for the whole series was 63 years (range 42-87). Cytogenetic abnormalities were detected in 16 (57%) out of 28 assessable patients, being classified as low risk (n=17), intermediate risk (n=5), and high risk (n=6) There were no significant differences among TN-PMF and F-MDS regarding age, sex, hematological values, spleen size or cytogenetic risk or the number of blasts in peripheral blood or bone marrow. Mutations were detected by NGS in 26 out of 28 (93%) patients. Median number of mutations was 3 (Range: 1-7). Most frequent mutated genes were: ASXL1 n=10 (36%), TET2 n=7 (25%), SRSF2 n=6 (21%), DNMT3A n=6 (21%), U2AF1 n=5 (18%), ETV6 n=4 (14%), SETBP1 n=3 (11%), RUNX1 n=3 (11%), EZH2 n=2 (7%), TP53 n=2 (7%), ZRSR2 n=2 (7%) and KMT2A n=2 (7%). Mutations in either TET2, U2AF1, SETBP1, TP53 or RUNX1 genes were observed in only 1 patient with TN-PMF in contrast with 12 out of 18 (67%) F-MDS cases (p=0.006). HMR mutations were detected in 12 cases (43%) with 7 of them (21%) carrying two or more HMR mutations. There were no significant differences among TN-PMF and F-MDS regarding the total number of mutations per case or in the presence of HMR mutations. Median survival was 1.6 and 3.7 years for patients with TN-PMF and F-MDS, respectively (p=0.4). Leukocyte count > 25x109/L and presence of blasts ≥ 1% in peripheral blood were associated with a significantly lower survival. High risk cytogenetics and ≥ 2 HMR mutations were associated with a tendency towards lower survival. Median survival was 1.6 years in patients with ≥ 3 mutations in comparison with 8.3 years in those with < 3 mutations, respectively (p=0.03). Progression to acute myeloid leukemia was observed in 11 patients, resulting in a probability of 32% at 3 years. There were no significant differences in the probability of progression to acute leukemia among TN-PMF and F-MFDS. Time to acute leukemia was significantly shorter in patients with ≥ 3 mutations (3-year probability 45% versus 16%, p=0.039). Conclusions: TN-PMF and F-MDS showed a high rate of mutations in myeloid genes with TET2, U2AF1, SETBP1, TP53 or RUNX1 being more frequently mutated in F-MDS. Despite survival being short in both entities, NGS allowed the identification of a subgroup of patients with especially poor prognosis characterized by the presence of ≥ 3 mutations. Disclosures Hernandez Boluda: Novartis: Consultancy; Incyte: Consultancy. Cervantes:Hospital Clinic Barcelona: Employment; Novartis: Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Celgene: Membership on an entity's Board of Directors or advisory committees.

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Córdoba-Ávila, Miguel Ángel, Nicolás Santiago-González, Raúl Vargas-Céspedes, Amelia de los Ángeles Arellano-Vera, Maribel López-Martínez, Daniela Moedano-Jiménez und Saúl Rojas-Martínez. „Deterioro de la piel asociado con aseguramiento del dispositivo de acceso intravascular“. Revista Ciencia y Cuidado 19, Nr. 2 (01.05.2022): 40–49. http://dx.doi.org/10.22463/17949831.3220.

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El deterioro de la piel asociado con adhesivos de uso médico en dispositivos de acceso intravascular es un evento adverso que puede contribuir a la interrupción de la terapia de infusión intravascular. La Sociedad de enfermeras de infusión recomienda usar tecnologías de protección como apósito estéril para aseguramiento del catéter y cinta quirúrgica para aseguramiento complementario. Objetivo: Analizar las causas y prevalencia del deterioro de la piel asociado con aseguramiento del dispositivo de acceso intravascular. Métodos: Estudio analítico, de corte transversal. Para recolectar datos se empleó un formato digital y observación directa a pacientes hospitalizados (n=813) con algún dispositivo de aseguramiento en acceso intravascular central o periférico, y aseguramiento complementario con cinta quirúrgica, dando seguimiento durante 7 días en febrero 2020. Resultados: El deterioro de la piel incluyó desprendimiento de epidermis, maceración, dermatitis irritativa por contacto y alérgica, con prevalencia de 2.2%. Se atribuyeron a catéter venoso central (f=8), catéter venoso periférico (f=7) y cinta quirúrgica para aseguramiento complementario del apósito transparente (f=3). Discusión: Las causas de deterioro de la piel se debieron al tipo de dispositivo y material implementado para aseguramiento; en la mayoría de casos las lesiones se encontraron en accesos venosos periféricos, seguida de accesos venosos centrales, siendo el aseguramiento complementario la menor causa de deterioro de la piel. Conclusiones: La técnica correcta de aplicación y retiro de insumos adhesivos de estabilización y aseguramiento del catéter intravascular evitará el desprendimiento de los mismos, lesiones de piel e interrupción de la terapia de infusión intravascular.

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Davies, Stephen. „Mary Lee Hummert, John M. Wiemann and Jon F. Nussbaum (eds), Interpersonal Communication in Older Adulthood: Interdisciplinary Theory and Research, Sage, London, 1994, 272 pp., hbk £37.50, ISBN 0 803 95116 7, pbk £19.50, ISBN 0 803 95117 5.“ Ageing and Society 15, Nr. 4 (Dezember 1995): 580–81. http://dx.doi.org/10.1017/s0144686x00003020.

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SB, Patil. „Anticancer Potential of Novel Pyrimidine Analogs: Recent Updates“. Medicinal and Analytical Chemistry International Journal 8, Nr. 1 (31.01.2024): 1–6. http://dx.doi.org/10.23880/macij-16000189.

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Pyrimidine, having two nitrogen atoms, looks like pyridine and benzene. In nature, pyrimidine is present in different forms, such as the bases of DNA and RNA. Due to its structure, various kinds of biological activity have been observed. The substituted and fused pyrimidine derivatives were chemically synthesized and showed anti-cancer potential against cancer cell lines (SW480, A549, CCRF-CEM, THP-1, HepG2, HCT-116, PC3, Huh-7, CNE-2, MGC-803, and MDA-MB-435). Based on the experimental results, the substituted pyrimidines and fused derivatives showed remarkably enhanced anticancer activity, which may be due to the presence of Cl, F, Br, CH3O, aryl urea, indolyl pyrimidine, thienopyrimidine, benzyl amino pyrimidine and the pyrimidine moiety. In this article, recent anticancer research findings were highlighted

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Obana, Akira, Ryo Asaoka, Ayako Miura, Miho Nozue, Yuji Takayanagi und Mieko Nakamura. „Improving Skin Carotenoid Levels in Young Students through Brief Dietary Education Using the Veggie Meter“. Antioxidants 11, Nr. 8 (14.08.2022): 1570. http://dx.doi.org/10.3390/antiox11081570.

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The antioxidant and anti-inflammatory effects of carotenoid have been determined to aid in the prevention of a wide range of oxidative disorders, arteriosclerosis, obesity, and various types of cancers. In order to keep high carotenoid levels in the body, much of the vegetable and fruit (V/F) intake is mandatory. However, the actual intake of V/F is not enough in many countries. The aim of this study was to assess whether brief dietary education using the Veggie Meter (VM) that could measure skin carotenoid (SC) levels could induce the increase in carotenoid levels via V/F intake. Two hundred and sixty-one elementary and junior high school students (ages 7–14 years old) received brief educational session and SC evaluation by VM, and the changes in SC levels were examined after 6 months. The baseline VM scores ranged from 131 to 825, and the average significantly increased from 400.0 ± 124.7 (standard deviation) to 447.4 ± 140.4 at Month 6 (p < 0.0001). The percentage of increase at month 6 was negatively correlated with the baseline values (r = −0.36, p < 0.0001). This finding implies that subjects who became aware of their inferiority tended to make a significant effort to change their behavior. The multivariate logistic regression analysis demonstrated that subjects taking much of green and yellow vegetables, drinking vegetable/tomato juice, and eating any fruit had higher VM scores than the average value. In conclusion, the educational approach using VM was supposed to be an effective method of raising awareness of the V/F shortage and increasing V/F intake that could indue the increase in SC levels.

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COOTE, BRIAN. „MORE LIGHT ON DUNLOP V. LAMBERT“. Cambridge Law Journal 57, Nr. 2 (Juli 1998): 235–73. http://dx.doi.org/10.1017/s0008197398270012.

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In their judgment in Alfred McAlpine Construction Ltd. v. Panatown Ltd. (The Times, 11 February 1998), the Court of Appeal has added yet another to the list of explanations for the rule in Dunlop v. Lambert (1839) 6 Cl. & F. 600; 7 E.R. 824. There, the House of Lords held that, where goods had been lost at sea, a consignor could recover substantial damages even though the goods, by the time of the loss, had become the property of the consignee. Since then, it has generally been accepted that the same result follows even though the consignee has neither title, risk, nor an immediate right to possession of the goods. It has also generally been assumed that the consignor holds the damages for the benefit of the true owner.

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Metcalfe, Travis S., Adam J. Finley, Oleg Kochukhov, Victor See, Thomas R. Ayres, Keivan G. Stassun, Jennifer L. van Saders et al. „The Origin of Weakened Magnetic Braking in Old Solar Analogs“. Astrophysical Journal Letters 933, Nr. 1 (30.06.2022): L17. http://dx.doi.org/10.3847/2041-8213/ac794d.

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Abstract The rotation rates of main-sequence stars slow over time as they gradually lose angular momentum to their magnetized stellar winds. The rate of angular momentum loss depends on the strength and morphology of the magnetic field, the mass-loss rate, and the stellar rotation period, mass, and radius. Previous observations suggested a shift in magnetic morphology between two F-type stars with similar rotation rates but very different ages (88 Leo and ρ CrB). In this Letter, we identify a comparable transition in an evolutionary sequence of solar analogs with ages between 2–7 Gyr. We present new spectropolarimetry of 18 Sco and 16 Cyg A and B from the Large Binocular Telescope, and we reanalyze previously published Zeeman Doppler images of HD 76151 and 18 Sco, providing additional constraints on the nature and timing of this transition. We combine archival X-ray observations with updated distances from Gaia to estimate mass-loss rates, and we adopt precise stellar properties from asteroseismology and other sources. We then calculate the wind braking torque for each star in the evolutionary sequence, demonstrating that the rate of angular momentum loss drops by more than an order of magnitude between the ages of HD 76151 and 18 Sco (2.6–3.7 Gyr) and continues to decrease modestly to the age of 16 Cyg A and B (7 Gyr). We suggest that this magnetic transition may represent a disruption of the global dynamo arising from weaker differential rotation, and we outline plans to probe this phenomenon in additional stars spanning a wide range of spectral types.

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Ridgman, W. J. „Subsistence Agriculture Improvement, ed. F. Goeltenboth. 228 pp. Weikersheim, German Federal Republic: Margraf Scientific Publishers (1990). Distributed by Gazelle Book Services (Lancaster). £14.75 (soft covers). ISBN 3 8236 1157 7.“ Journal of Agricultural Science 116, Nr. 2 (April 1991): 326. http://dx.doi.org/10.1017/s0021859600077790.

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Roy, Pierre-Alexis, Björn Benneke, Caroline Piaulet, Ian J. M. Crossfield, Laura Kreidberg, Diana Dragomir, Drake Deming et al. „Is the Hot, Dense Sub-Neptune TOI-824 b an Exposed Neptune Mantle? Spitzer Detection of the Hot Dayside and Reanalysis of the Interior Composition“. Astrophysical Journal 941, Nr. 1 (01.12.2022): 89. http://dx.doi.org/10.3847/1538-4357/ac9f18.

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Abstract The Kepler and TESS missions revealed a remarkable abundance of sub-Neptune exoplanets. Despite this abundance, our understanding of the nature and compositional diversity of sub-Neptunes remains limited, to a large part because atmospheric studies via transmission spectroscopy almost exclusively have aimed for low-density sub-Neptunes, and even those were often affected by high-altitude clouds. The recent TESS discovery of the hot, dense TOI-824 b (2.93 R ⊕ and 18.47 M ⊕) opens a new window into sub-Neptune science by enabling the study of a dense sub-Neptune via secondary eclipses. Here, we present the detection of TOI-824 b’s hot dayside via Spitzer secondary-eclipse observations in the 3.6 and 4.5 μm channels, combined with a reanalysis of its interior composition. The measured eclipse depths (142 − 52 + 57 and 245 − 77 + 75 ppm) and brightness temperatures (1463 − 196 + 183 and 1484 − 202 + 180 K) indicate a poor heat redistribution (f < 0.49) and a low Bond albedo (A B < 0.26). We conclude that TOI-824 b could be an “exposed Neptune mantle”: a planet with a Neptune-like water-rich interior that never accreted a hydrogen envelope or that subsequently lost it. The hot dayside temperature is then naturally explained by a high-metallicity envelope reemitting the bulk of the incoming radiation from the dayside. TOI-824 b’s density is also consistent with a massive rocky core that accreted up to 1% of hydrogen, but the observed eclipse depths favor our high-metallicity general circulation model (GCM) simulation to a solar-metallicity GCM simulation with a likelihood ratio of 7:1. The new insights into TOI-824 b’s nature suggest that the sub-Neptune population may be more diverse than previously thought, with some of the dense hot sub-Neptunes potentially not hosting a hydrogen-rich envelope as generally assumed for sub-Neptunes.

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Griebenow, Kai, Alfred R. Holzwarth und Kurt Schaffner. „The 5.6-Kilodalton Protein in Isolated Chlorosomes of Chloroflexus aurantiacus Strain Ok -70-fl is a Degradation Product“. Zeitschrift für Naturforschung C 45, Nr. 7-8 (01.08.1990): 823–28. http://dx.doi.org/10.1515/znc-1990-7-813.

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Abstract Chlorosomcs containing BChl a790 have been isolated from Chloroflexus aurantiacus on sucrose density gradients using the detergents Miranol. Deriphat. N.N-dimethyldodecyl- aminc-N-oxidc, and dodecyl-p-D-rnaltoside. All freshly prepared samples cither lack the poly- peptide of approximately 5 kDa. which appears identical with the 5.6-kDa protein previously assigned the role of BChl c-binding [R. G. Feick and R. C. Fuller. Biochemistry 23, 3693- 3700 (1984)]. or they contain only a minor amount thereof. This polypeptide accumulates in the chlorosomcs in vitro at room temperature within 24 h after isolation. The reaction cannot be prevented simply by addition of the protease inhibitors benzamidinc. F.-caproic ac|d. and phenylmethylsulfonyl fluoride. However, upon denaturation, as required lor gel electrophore- sis, of the freshly isolated chlorosome sample the formation of the 5-kDa polypeptide is inhibit- ed. We conclude that this species, viz. 5.6-kDa protein, is a degradation product of another - as yet unidentified - protein present in the chlorosome preparations. Despite the pronounced proteolytic activity which affords the 5-kDa fragment, the native absorption and fluorescence properties of BChl c and BChl a arc essentially not changed in these chlorosome preparations.

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Wagner, C. D., R. Mrowka, B. Nafz und P. B. Persson. „Complexity and "chaos" in blood pressure after baroreceptor denervation of conscious dogs“. American Journal of Physiology-Heart and Circulatory Physiology 269, Nr. 5 (01.11.1995): H1760—H1766. http://dx.doi.org/10.1152/ajpheart.1995.269.5.h1760.

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To investigate how arterial baroreceptors affect the dynamic properties of short-term blood pressure control, we determined Lyapunov exponents and correlation dimensions of blood pressure. Two groups of conscious dogs were studied: a control group (n = 7) and a group subjected to total sinoaortic and cardiopulmonary baroreceptor denervation (n = 7). As a measure of variability, standard deviation was determined and power spectra were calculated. In the lower frequency range (f < 0.1 Hz) power density was inversely related to frequency in both groups, indicating "1/f noise." Estimating the correlation dimension via the Grassberger-Procaccia algorithm as a quantification of complexity revealed a decrease after baroreceptor denervation (1.74 +/- 0.2 vs. 3.05 +/- 0.23 control; P < 0.05). Determination of the largest Lyapunov exponents lambda 1, which indicates the sensitive dependence on initial conditions, a hallmark of chaos, also yielded a diminution after denervation (lambda 1 = 0.74 +/- 0.08 vs. 1.85 +/- 0.18, P < 0.01). The results were cross-checked with surrogate data statistics. The null hypothesis, that there is no nonlinear structure in arterial blood pressure time series, was rejected. This shows that after baroreceptor denervation, blood pressure control is less complex and less sensitive to initial conditions ("chaos"). In contrast, variability (standard deviation) is increased (22.2 +/- 3.1 denervation vs. 8.3 +/- 1.4 control; P < 0.05). It is concluded that under physiological conditions, arterial and cardiopulmonary baroreceptors reduce variability of blood pressure, however, at the cost of blood pressure being less predictable. Thus the regulation is more sensitive depending on initial conditions.(ABSTRACT TRUNCATED AT 250 WORDS)

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Frénoy, J. P., A. T. Tran und R. Bourrillon. „Structure and stability of Ricinus communis haemagglutinin“. Biochemical Journal 240, Nr. 1 (15.11.1986): 227–31. http://dx.doi.org/10.1042/bj2400227.

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The molecular properties of the haemagglutinin of Ricinus communis (RCA I or RCA 120) were evaluated by analytical ultracentrifugation, light-scattering, c.d. and fluorescence. The native molecule had a fairly expanded structure (f/f0 = 1.43) and dissociated into two subunits of equal size in 6 M-guanidinium chloride. This native structure was stable in alkali (up to pH 11) and resistant to thermal denaturation at neutrality. A pH-triggered change in the haemagglutinin conformation was observed and characterized by analytical ultracentrifugation, c.d. and fluorescence between pH 7 and 4.5, the range in which its affinity for galactosides decreased [Yamasaki, Absar & Funatsu (1985) Biochim, Biophys. Acta 828, 155-161]. These results are discussed in relation to those reported in the literature for other lectins and more especially ricin, for which a pH-dependent conformation transition has been observed in the same range of low pH.

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Ye, Neng, Zhenya Wu, Xiaohui Wu, Yonglai Lu und Liqun Zhang. „Performance Enhancement of Polymerized, Functionalized Solution Styrene–Butadiene Rubber Composites Using Oligomeric Resin towards Extremely Safe and Energy-Saving Tires“. Polymers 14, Nr. 14 (20.07.2022): 2928. http://dx.doi.org/10.3390/polym14142928.

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Polymerized, functionalized solution styrene–butadiene rubber (F-SSBR) is a new type of polymerized styrene–butadiene rubber solution containing specific terminal groups, which can be used in treads for high performances. However, the wet skid resistance related to safety, the rolling resistance to energy consumption, and the wear resistance to service life are often contradictory and form the performance “magic triangle”. In this work, oligomeric resins, including Coumarone resin, C9 resin, C5/C9 resin and a styrene-α-methyl styrene copolymer (SSC), were used as tire functional additives and selected to replace treated distillate aromatic extract (TDAE) to improve the performances of silica-filled F-SSBR composites. The C9 resin, C5/C9 resin and SSC could enhance the modulus at 300% and tensile strength of the F-SSBR composite. The four resins could improve the wet skid resistance and wear resistance of the composites. However, Coumarone resin caused poor silica dispersion in the F-SSBR matrix and eventually, the lower modulus, higher loss factor at 60 °C and the higher heat buildup in the composite were comparative to the composite with TDAE. Furthermore, the synergistic effect of the C5/C9 resin and SSC was found to improve the mechanical performance of the composites and it resulted in higher tensile strength and modulus, and a lower heat buildup, compared to the case when only TDAE was used. It is noted that the properties “magic triangle” was broken by the C5/C9 resin and SSC, and the C5/C910T15 increased the wet skid resistance by 21.7%, fuel-saving rate by 2.3%, and wear resistance by 8.3%, while S20T5 increased the wet skid resistance by 30.4%, fuel-saving rate by 7%, and wear resistance by 25% compared with CG.

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Burton, Kiana, Meredith A. MacGregor und Rachel A. Osten. „First Millimeter Flares Detected from ϵ Eridani with the Atacama Large Millimeter/submillimeter Array“. Astrophysical Journal Letters 939, Nr. 1 (26.10.2022): L6. http://dx.doi.org/10.3847/2041-8213/ac9973.

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Abstract We report the detection of three large millimeter flaring events from the nearby Sun-like, ϵ Eridani, found in archival Atacama Large Millimeter/submillimeter Array (ALMA) 12 m and Atacama Compact Array observations at 1.33 mm taken from 2015 January 17 to 18 and 2016 October 24 to November 23, respectively. This is the first time that flares have been detected from a Sun-like star at millimeter wavelengths. The largest flare among our data was detected in the ALMA observations on 2015 January 17 from 20:09:10.4–21:02:49.3 UT with a peak flux density of 28 ± 7 mJy and a duration of 9 s. The peak brightness of the largest flare is 3.4 ± 0.9 × 1014 erg s−1 Hz−1, a factor of >50× times brighter than the star’s quiescent luminosity and >10× brighter than solar flares observed at comparable wavelengths. We find changes in the spectral index (F ν ∝ ν α ) at the flare peak, with α = 1.81 ± 1.94 and a lower limit on the fractional linear polarization ∣Q/I∣ = 0.08 ± 0.12. This positive spectral index is more similar to millimeter solar flares, differing from M-dwarf flares also detected at millimeter wavelengths that exhibit steeply negative spectral indices.

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Langeroodi, Danial, und Jens Hjorth. „Little Red Dots or Brown Dwarfs? NIRSpec Discovery of Three Distant Brown Dwarfs Masquerading as NIRCam-selected Highly Reddened Active Galactic Nuclei“. Astrophysical Journal Letters 957, Nr. 2 (01.11.2023): L27. http://dx.doi.org/10.3847/2041-8213/acfeec.

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Abstract Cold, substellar objects such as brown dwarfs have long been recognized as contaminants in color-selected samples of active galactic nuclei (AGNs). In particular, their near- to mid-infrared colors (1–5 μm) can closely resemble the V-shaped (f λ ) spectra of highly reddened accreting supermassive black holes (“little red dots”), especially at 6 < z < 7. Recently, a NIRCam-selected sample of little red dots over 45 arcmin2 has been followed up with deep NIRSpec multiobject prism spectroscopy through the UNCOVER program. By investigating the acquired spectra, we identify 3 of the 14 followed-up objects as T/Y dwarfs with temperatures between 650 and 1300 K and distances between 0.8 and 4.8 kpc. At 4.8 − 0.1 + 0.6 kpc, A2744-BD1 is the most distant brown dwarf discovered to date. We identify the remaining 11 objects as extragalactic sources at z spec ≳ 5. Given that three of these sources are strongly lensed images of the same AGN (A2744-QSO1), we derive a brown dwarf contamination fraction of 25% in this NIRCam selection of little red dots. We find that in the near-infrared filters, brown dwarfs appear much bluer than the highly reddened AGN, providing an avenue for distinguishing the two and compiling cleaner samples of photometrically selected highly reddened AGN.

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Gottlieb, A. B., J. F. Merola, A. Armstrong, R. Langley, M. Lebwohl, C. E. M. Griffiths, M. Shawi et al. „AB0528 COMPARABLE SAFETY PROFILE OF GUSELKUMAB IN PSORIATIC ARTHRITIS AND PSORIASIS: RESULTS FROM PHASE 3 TRIALS THROUGH 1 YEAR“. Annals of the Rheumatic Diseases 80, Suppl 1 (19.05.2021): 1293–94. http://dx.doi.org/10.1136/annrheumdis-2021-eular.556.

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Background:DISCOVER 1&2 (PsA) and VOYAGE 1&2 (PsO) are Phase 3 trials of guselkumab (GUS).Objectives:Compare safety results through up to 1yr of GUS in PsA and PsO pts.Methods:In DISCOVER, 1120 pts with active PsA despite standard therapy were treated. Most pts were biologic-naïve; ~30% in DISCOVER 1 had previous exposure to 1-2 TNFi. Concomitant MTX (57%), oral corticosteroids (17%), and NSAIDs (64%) were permitted. Pts were randomized to SC GUS 100mg at W0, W4, then Q8W; GUS 100mg Q4W; or PBO. At W24, PBO patients were switched to GUS 100mg Q4W. In VOYAGE, in which concomitant MTX use was prohibited, 1245 pts with moderate to severe PsO were treated and randomized to SC GUS 100 mg at W0, W4, W12, then Q8W; or PBO at W0, W4, W12, with crossover to GUS at W16, W20, then Q8W. AEs and laboratory parameters, analyzed by National Cancer Institute-Common Terminology Criteria for AEs [NCI-CTCAE] toxicity grades, were summarized through the PBO-controlled periods and 1yr.Results:Safety profiles were generally consistent across the GUS PsO and PsA clinical programs (Table 1). Time-adjusted incidence rates for numbers of AEs, serious AEs, serious infections, malignancy, MACE and AEs leading to d/c were generally similar between PsO and PsA. No cases of anaphylaxis or opportunistic infections were reported. Proportions of pts with decreased neutrophil counts and elevations in hepatic transaminases were slightly higher in PsA vs PsO. These abnormalities were mostly of NCI-CTCAE Grade 1 or 2 (<LLN-1000/mm3 for neutrophils; <5.0 x ULN for AST/ ALT), generally transient, required no medical interventions, resolved spontaneously, and did not lead to interruption or d/c of treatment. Through 1yr, proportions of pts with ALT/AST elevations in PsA trials were slightly higher for GUS Q4W than Q8W and in pts with vs without baseline MTX use.Conclusion:The GUS safety profile was generally consistent in PsA and PsO GUS-treated pts through 1yr of the DISCOVER and VOYAGE trials.Table 1.Treatment-Emergent AEs During PBO-controlled Period and Through 1Yr: VOYAGE & DISCOVER TrialsPooled VOYAGE 1&2Pooled DISCOVER 1&2Time PeriodW0-16Through 1YrW0-24bThrough 1Yr(N=)PBO(422)GUS Q8W(823)Combined GUSa(1221)PBOc(372)GUS Q8W(375)GUS Q4W (373)GUS Q8W(375)GUS Q4W (373)Combined GUS† (1100)Total pt-yrs of follow-up128255974173173172384385973Incidence/100 pt-yrs (95% CI)dAEs317 (287,349)330 (308,353)259 (249, 270)219 (198,243)256 (232,281)221 (200, 245)218 (203,233)177 (164,191)191 (182, 199)SAEs5 (2, 10)6 (4, 10)6 (5, 8)9 (5, 15)4 (2, 8)5 (2, 10)6 (4, 9)4 (2, 7)6 (4, 7)AEs leading to study agent d/c3 (0.9, 8)4 (2, 8)2 (2, 4)4 (2, 8)3 (1, 7)7 (4, 12)2 (1, 4)4 (2, 6)3 (2, 5)Infections86 (71, 104)98 (86, 111)98 (92, 104)58 (48, 71)58 (47, 71)63 (51, 76)58 (50, 66)53 (46, 61)55 (50, 60)Serious Infections0. 8 (0, 4)0.4 (0, 2)1 (0.5, 2)4 (2, 8)0.6 (0, 3)2 (0.4, 5)2 (0.6, 3)1 (0, 2)2 (0.9, 3)All Malignancy0 (0, 2)0.4 (0, 2)1 (0.4, 2)0.6 (0, 3)1 (0, 4)0 (0, 2)0.5 (0, 2)0 (0, 0. 8)0 (0, 1)MACE0 (0, 2)0.4 (0, 2)0.4 (0, 1)0.6 (0, 3)0 (0, 2)0.6 (0, 3)0 (0, 0.8)0.3 (0, 1.4)0.1 (0, 0.6)% pts with ≥1 injection site rxn3.14.55.00.31.31.11.62.41.7aPlacebo crossover pts were included in the combined GUS column after crossover to GUSbFor all pts who d/c study treatment early with the last dose of PBO/GUS prior to W24 and who did not receive any PBO/GUS at or after Wk24, all data including the final safety follow-up visit collected through 1yr were includedcFor pts in PBO group who switched to GUS due to cross-over or inadvertently, only data prior to first administration of GUS were included.dCI based on an exact method assuming observed number of events follows a Poisson distributionDisclosure of Interests:Alice B Gottlieb Consultant of: Anaptyps Bio, Avotres Therapeutics, Beiersdorf, Boehringer Ingelheim, Bristol-Myers-Squibb, Eli Lilly, Janssen, LEO Pharma, Novartis, Sun Pharmaceuticals, UCB, and Xbiotech, Grant/research support from: Boehringer Ingelheim, Janssen, Novartis, Sun Pharmaceuticals, UCB, and Xbiotech, Joseph F. Merola Consultant of: AbbVie, Arena, Biogen, BMS, Dermavant, Eli Lilly, Janssen, Novartis, Pfizer, Sun Pharma, UCB, April Armstrong Consultant of: AbbVie, Janssen, Lilly, Leo, Novartis, UCB, Ortho Dermatologics, Dermira, KHK, Sanofi, Regeneron, Sun Pharma, BMS, Dermavant, and Modernizing Medicine, Richard Langley Speakers bureau: AbbVie, Amgen, Boehringer Ingelheim, Celgene, Eli Lilly, Janssen, LEO Pharma, Merck, Novartis, Pizer, Sun Pharmaceutical, and UCB Pharma, Consultant of: AbbVie, Amgen, Boehringer Ingelheim, Celgene, Eli Lilly, Janssen, LEO Pharma, Merck, Novartis, Pizer, Sun Pharmaceutical, and UCB Pharma, Mark Lebwohl Consultant of: Aditum Bio, Allergan, Almirall, Arcutis, Inc., Avotres Therapeutics, BirchBioMed Inc., BMD skincare, Boehringer-Ingelheim, Bristol-Myers Squibb, Cara Therapeutics, Castle Biosciences, Corrona, Dermavant Sciences, Evelo, Evommune, Facilitate International Dermatologic Education, Foundation for Research and Education in Dermatology, Inozyme Pharma, Kyowa Kirin, LEO Pharma, Meiji Seika Pharma, Menlo, Mitsubishi, Neuroderm, Pfizer, Promius/Dr. Reddy’s Laboratories, Serono, Theravance, and Verrica., Grant/research support from: Abbvie, Amgen, Arcutis, Boehringer Ingelheim, Dermavant, Eli Lilly, Evommune, Incyte, Janssen, Leo Pharmaceutucals, Ortho Dermatologics, Pfizer, and UCB, Christopher E.M. Griffiths Speakers bureau: AbbVie, Amgen, Almirall, BMS, Boehringer Ingelheim Celgene, Janssen, LEO Pharma, Lilly, Novartis, Pfizer, Sun Pharma, UCB Pharma., Consultant of: AbbVie, Amgen, Almirall, BMS, Boehringer Ingelheim Celgene, Janssen, LEO Pharma, Lilly, Novartis, Pfizer, Sun Pharma, UCB Pharma., Grant/research support from: AbbVie, Amgen, Almirall, BMS, Boehringer Ingelheim Celgene, Janssen, LEO Pharma, Lilly, Novartis, Pfizer, Sun Pharma, UCB Pharma., May Shawi Shareholder of: Johnson & Johnson, Employee of: Janssen Global Services, LLC, Ya-Wen Yang Shareholder of: Johnson & Johnson, Employee of: Janssen Global Services, LLC, Elizabeth C Hsia Shareholder of: Johnson & Johnson, Employee of: Janssen Research & Development, LLC, Alexa Kollmeier Shareholder of: Johnson & Johnson, Employee of: Janssen Research & Development, LLC, Xie L Xu Shareholder of: Johnson & Johnson, Employee of: Janssen Research & Development, LLC, Miwa Izutsu Shareholder of: Johnson & Johnson, Employee of: Janssen Research & Development, LLC, Paraneedharan Ramachandran Shareholder of: Johnson & Johnson, Employee of: Janssen Research & Development, LLC, Shihong Sheng Shareholder of: Johnson & Johnson, Employee of: Janssen Research & Development, LLC, Yin You Shareholder of: Johnson & Johnson, Employee of: Janssen Research & Development, LLC, Megan Miller Shareholder of: Johnson & Johnson, Employee of: Janssen Research & Development, LLC, Christopher T. Ritchlin Consultant of: AbbVie, Amgen, Gilead, Janssen, Lilly, Novartis, Pfizer, and UCB Pharma, Grant/research support from: AbbVie, Amgen, and UCB Pharma, Iain McInnes Consultant of: AbbVie, Bristol-Myers Squibb, Celgene, Eli Lilly and Company, Gilead, and Janssen, Novartis, Pfizer, and UCB, Grant/research support from: Bristol-Myers Squibb, Celgene, Eli Lilly and Company, Janssen, and UCB, Proton Rahman Speakers bureau: AbbVie, Eli Lilly, Janssen, Novartis, Pfizer, and UCB, Consultant of: AbbVie, Amgen, Bristol Myers Squibb, Celgene, Eli Lilly, Janssen, Novartis, Pfizer, Roche, and UCB, Grant/research support from: Janssen and Novartis.

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