Thematische Bibliographien / 801/.95

Auswahl der wissenschaftlichen Literatur zum Thema „801/.95“

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Veröffentlicht am 25. Juli 2024

Zuletzt aktualisiert am 26. Juli 2024

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Zeitschriftenartikel zum Thema "801/.95"

van Lookeren Campagne, Menno, Jeroen B. Verheul, Klaas Nicolay und Robert Balázs. „Early Evolution and Recovery from Excitotoxic Injury in the Neonatal Rat Brain: A Study Combining Magnetic Resonance Imaging, Electrical Impedance, and Histology“. Journal of Cerebral Blood Flow & Metabolism 14, Nr. 6 (November 1994): 1011–23. http://dx.doi.org/10.1038/jcbfm.1994.133.

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We explored the therapeutic potentials of two N-methyl-d-aspartate (NMDA) receptor antagonists in vivo using different techniques. NMDA injected into the striatum of neonatal rats (20 nmol/0.5 μl) induced a rapid increase in the diffusion-weighted (DW) image intensity, spreading over a large part of the ipsilateral hemisphere. Subcutaneous injection of the NMDA receptor antagonist MK-801 (1 mg/kg) or d-( E)-4-(3-phosphono-2-prop-enyl)-2-piperazine-carboxylic acid (D-CPPene; 1.5 mg/kg) reversed both the volume and the grading of the NMDA-induced hyperintensity of DW images, the reversal by MK-801 being more rapid than that by D-CPPene. In the cerebral cortex, there was an inverse relationship between changes in DW image intensity and the size of the extracellular space, assessed by electrical impedance measurements. The reduction of the hyperintense volume in DW images 1 or 2 h after MK-801 or D-CPPene treatment of NMDA-injected animals depended on the type of antagonist used and on the interval between intrastriatal NMDA injection and antagonist treatment. The reduction was 95% when MK-801 was given with a delay of 90 min and decreased to 20% when it was given at 360 min. With D-CPPene, the reduction was 80% after a delay of 30 min and virtually absent when it was administered at 360 min. Quantitative analysis showed significant correlations between the residual hyperintense volume 1 or 2 h after MK-801 or D-CPPene treatment and the final lesion volume, assessed from either T2-weighted images ( R = 0.89, p < 0.001) or histology ( R = 0.80, p < 0.001) 5 days after the insult. This study illustrates the sensitivity of DW magnetic resonance imaging to monitor in vivo early events after an excitotoxic insult and the effect of putative protective drugs that may counteract the resulting damage.

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Jiang, Honglin, Jialin Guo, Jing Li, Chunlin Li, Wenchong Du, Federico Canavese, Charlie Baker, Hao Ying und Jing Hua. „Artificial Neural Network Modeling to Predict Neonatal Metabolic Bone Disease in the Prenatal and Postnatal Periods“. JAMA Network Open 6, Nr. 1 (23.01.2023): e2251849. http://dx.doi.org/10.1001/jamanetworkopen.2022.51849.

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ImportanceEarly recognition of metabolic bone disease (MBD) in infants is necessary but difficult; an appropriate tool to screen infants at risk of developing MBD is needed.ObjectivesTo develop a predictive model for neonates at risk for MBD in the prenatal and postnatal periods and detect the pivotal exposed factors in each period.Design, Setting, and ParticipantsA diagnostic study was conducted from January 1, 2012, to December 31, 2021, in Shanghai, China. A total of 10 801 pregnant women (singleton pregnancy, followed up until 1 month after parturition) and their infants (n = 10 801) were included. An artificial neural network (ANN) framework was used to build 5 predictive models with different exposures from prenatal to postnatal periods. The receiver operating characteristic curve was used to evaluate the model performance. The importance of each feature was examined and ranked.ResultsOf the 10 801 Chinese women who participated in the study (mean [SD] age, 29.7 [3.9] years), 7104 (65.8%) were local residents, 1001 (9.3%) had uterine scarring, and 138 (1.3%) gave birth to an infant with MBD. Among the 5 ANN models, model 1 (significant prenatal and postnatal factors) showed the highest AUC of 0.981 (95% CI, 0.970-0.992), followed by model 5 (postnatal factors; AUC, 0.977; 95% CI, 0.966-0.988), model 4 (all prenatal factors; AUC, 0.850; 95% CI, 0.785-0.915), model 3 (gestational complications or comorbidities and medication use; AUC, 0.808; 95% CI, 0.726-0.891), and model 2 (maternal nutritional conditions; AUC, 0.647; 95% CI, 0.571-0.723). Birth weight, maternal age at pregnancy, and neonatal disorders (anemia, respiratory distress syndrome, and septicemia) were the most important model 1 characteristics for predicting infants at risk of MBD; among these characteristics, extremely low birth weight (importance, 50.5%) was the most powerful factor. The use of magnesium sulfate during pregnancy (model 4: importance, 21.2%) was the most significant predictor of MBD risk in the prenatal period.Conclusions and RelevanceIn this diagnostic study, ANN appeared to be a simple and efficient tool for identifying neonates at risk for MBD. Combining prenatal and postnatal factors or using postnatal exposures alone provided the most precise prediction. Extremely low birth weight was the most significant predictive factor, whereas magnesium sulfate use during pregnancy could be an important bellwether for MBD before delivery.

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Hitchcock, Ian S., Timothy M. Skerry, Martin R. Howard und Paul G. Genever. „NMDA receptor–mediated regulation of human megakaryocytopoiesis“. Blood 102, Nr. 4 (15.08.2003): 1254–59. http://dx.doi.org/10.1182/blood-2002-11-3553.

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Abstract Identification of the regulatory inputs that direct megakaryocytopoiesis and platelet production is essential for the development of novel therapeutic strategies for the treatment of thrombosis and related hematologic disorders. We have previously shown that primary human megakaryocytes express the N-methyl-d-aspartate acid (NMDA) receptor 1 (NR1) subunit of NMDA-type glutamate receptors, which appear to be pharmacologically similar to those identified at neuronal synapses, responsible for mediating excitatory neurotransmission in the central nervous system. However, the functional role of NMDA receptor signaling in megakaryocytopoiesis remains unclear. Here we provide evidence that demonstrates the fundamental importance of this signaling pathway during human megakaryocyte maturation in vitro. Reverse transcriptase–polymerase chain reaction (RT-PCR) analysis of RNA extracted from CD34+-derived megakaryocytes identified expression of NR2A and NR2D receptor subunits in these cells, as well as the NMDA receptor accessory proteins, Yotiao and postsynaptic density protein 95 (PSD-95). In functional studies, addition of a selective NMDA receptor antagonist, MK-801 inhibited proplatelet formation, without affecting proliferation or apoptosis. Exposure of CD34+ cells to MK-801 cultured for 14 days in the presence of thrombopoietin induced a decrease in expression of the megakaryocyte cell surface markers CD61, CD41a, and CD42a compared with controls. At an ultrastructural level, MK-801–treated cells lacked α-granules, demarcated membranes, and multilobed nuclei, which were prominent in untreated mature megakaryocyte controls. Using immunohistochemistry on sections of whole tibiae from c-Mpl knockout mice we demonstrated that megakaryocytic NMDA receptor expression was maintained following c-Mpl ablation. These data support a fundamental role for glutamate signaling in megakaryocytopoiesis and platelet production, which is likely to be independent of thrombopoietin-mediated effects.

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Яснецов, Вик В., Т. А. Воронина, С. Я. Скачилова und Владимир Викторович Яснецов. „Эффекты эмопага на переживающих срезах гиппокампа крыс“. Экспериментальная и клиническая фармакология 82, Nr. 8 (22.09.2019): 37–40. http://dx.doi.org/10.30906/0869-2092-2019-82-8-37-40.

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На переживающих срезах гиппокампа крыс эмопаг и мексидол в концентрации 4 мМ подавляли ортодромные популяционные ответы в поле СA1 на 58 ± 4 % и 43 ± 3 % соответственно. Специфический неконкурентный антагонист NMDA-рецепторного комплекса МК-801 ослаблял угнетающее действие эмопага на 38 ± 4 %, а мексидола — на 73 ± 6 %, действуя в отношении первого в 1,9 раза менее выраженно. Специфический блокатор глутаматных AMPA-рецепторов CNQX практически полностью блокировал депрессирующий эффект эмопага либо ослаблял его на 54 ± 5 %, действуя по крайней мере в 1,4 раза более выраженно, чем МК-801. В пирамидных нейронах поля СA1 гиппокампа крысят эмопаг (2 мМ) угнетал возбуждающий постсинаптический ток, вызванный раздражением коллатералей Шаффера, на 92 ± 3 %, а на фоне действия специфического блокатора глутаматных AMPA-рецепторов NBQX его депрессирующий эффект практически полностью ослаблялся на 95 ± 4 %. Следовательно, можно предполагать, что гиппокамп играет существенную роль в реализации центрального действия эмопага. При этом его эффект реализуется через активацию AMPA-рецепторов.

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Olén, Ola, Johan Askling, Michael C. Sachs, Martin Neovius, Karin E. Smedby, Anders Ekbom und Jonas F. Ludvigsson. „Mortality in adult-onset and elderly-onset IBD: a nationwide register-based cohort study 1964–2014“. Gut 69, Nr. 3 (15.05.2019): 453–61. http://dx.doi.org/10.1136/gutjnl-2018-317572.

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ObjectivesTo examine all-cause and cause-specific mortality in adult-onset and elderly-onset IBD and to describe time trends in mortality over the past 50 years.DesignSwedish nationwide register-based cohort study 1964–2014, comparing mortality in 82 718 incident IBD cases (inpatient and non-primary outpatient care) with 10 times as many matched general population reference individuals (n=801 180) using multivariable Cox regression to estimate HRs. Among patients with IBD, the number of participants with elderly-onset (≥60 years) IBD was 17 873.ResultsDuring 984 330 person-years of follow-up, 15 698/82 718 (19%) of all patients with IBD died (15.9/1000 person-years) compared with 121 095/801 180 (15.1%) of reference individuals, corresponding to an HR of 1.5 for IBD (95% CI=1.5 to 1.5 (HR=1.5; 95% CI=1.5 to 1.5 in elderly-onset IBD)) or one extra death each year per 263 patients. Mortality was increased specifically for UC (HR=1.4; 95% CI=1.4 to 1.5), Crohn’s disease (HR=1.6; 95% CI=1.6 to 1.7) and IBD-unclasssified (HR=1.6; 95% CI=1.5 to 1.8). IBD was linked to increased rates of multiple causes of death, including cardiovascular disease (HR=1.3; 1.3 to 1.3), malignancy (HR=1.4; 1.4 to 1.5) and digestive disease (HR=5.2; 95% CI=4.9 to 5.5). Relative mortality during the first 5 years of follow-up decreased significantly over time. Incident cases of 2002–2014 had 2.3 years shorter mean estimated life span than matched comparators.ConclusionsAdult-onset and elderly-onset patients with UC, Crohn’s disease and IBD-unclassified were all at increased risk of death. The increased mortality remained also after the introduction of biological therapies but has decreased over time.

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Fu, Ying, Yan Sun, Qianqian Pei, Xiaobo Han, Wen Qin, Fang Mei, Shi Tan und Ligang Cui. „Factors Influencing the Sample Adequacy of Ultrasound-Guided Fine-Needle Aspiration from Solid Thyroid Nodules for Liquid-Based Cytology: A Demographic, Sonographic, and Technical Perspective“. Medicina 58, Nr. 11 (13.11.2022): 1639. http://dx.doi.org/10.3390/medicina58111639.

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Background and Objectives: To identify factors that influence the sample adequacy of solid thyroid nodules based on ultrasound-guided fine-needle aspiration (FNA) with subsequent liquid-based cytology. Materials and Methods: We retrospectively reviewed 855 patients who underwent ultrasound-guided FNA at our hospital between July 2019 and July 2020. The final analysis included 801 solid thyroid nodules in 801 patients. After reviewing the demographic data, ultrasonic features, and FNA technique-related factors, we defined 14 potential variables. For cytological results, the Bethesda categories II–VI were defined as adequate sample results. Univariate and multivariate analyses were performed to identify factors that influenced sample adequacy. Results: The adequate sample rate was 87.1%. The univariate analysis showed that four factors were related to adequate sampling in patients with thyroid FNA. These factors included age (p < 0.001), nodule orientation (p = 0.0232), calcification (p = 0.0034), and operator experience (p = 0.0286). After the multivariate analysis, five independent factors were identified to improve the diagnostic results of FNA for solid thyroid nodules: (1) the presence of Hashimoto’s thyroiditis (odds ratio (OR) = 1.810; 95% confidence interval (CI): 1.076–3.045; p = 0.0254), (2) a taller-than-wide orientation (OR = 2.038; 95% CI: 1.260–3.296; p = 0.0037), (3) the presence of calcification (OR = 1.767; 95% CI: 1.115–2.799; p = 0.0153), (4) four needle passes to obtain material (OR = 1.750; 95% CI: 1.094–2.799; p = 0.0196), and (5) an experienced operator (OR = 0.561; 95% CI: 0.319–0.987; p = 0.0451). Conclusions: A taller-than-wide orientation, the presence of calcification, and the presence of Hashimoto’s thyroiditis were found to affect the sample adequacy of ultrasound-guided FNA with liquid-based cytology. The sample adequacy could be improved when FNA is performed with four needle passes by experienced doctors.

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Allpas-Gómez, Henry Lowell, Jarvis Raraz-Vidal und Omar Raraz-Vidal. „Factores asociados al bajo peso al nacer en un hospital de Huánuco“. ACTA MEDICA PERUANA 31, Nr. 2 (29.06.2014): 79. http://dx.doi.org/10.35663/amp.2014.312.200.

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Introducción. El bajo peso al nacer (BPN) es un importante indicador de salud fetal, neonatal y de las condiciones de la gestación. Objetivo: identificar factores asociados al BPN en el Hospital Carlos Showing Ferrari de Huánuco, Perú. Material y método. Estudio descriptivo, retrospectivo de corte transversal. Se realizó en el servicio de Ginecoobstetricia del Hospital Carlos Showing Ferrari de Huánuco. Participantes. Madre e hijos atendidos en el servicio de Gineco-obstetricia. Intervenciones. Según los criterios de inclusión y exclusión se obtuvo, 801 madreshijos registrados en el Sistema Informático Perinatal (SIP) del 2011. Se utilizó un instrumento de recolección validado, se obtuvo información del SIP e historias clínicas, durante 6 meses. Se realizó el análisis descriptivo; para el análisis inferencial se usó la prueba ji cuadrado con una significancia del 95 %. Se empleó el paquete estadístico SPSS y Microsoft Excel. Resultados. De los 801 nacidos, el peso promedio fue 3 217,8 (+ 446,1) gramos y una p revalencia de BPN de 6,2 %. Los factores asociados que resultaron estadísticamente significativos fueron: la primiparidad con p = 0,013(IC-95%: 1,16-3,81); número de controles prenatales (menor de cuatro) con p < 0,05 (IC95%: 2,63-8,74) y parto pretérmino con p < 0,05 (IC95%: 0,01-0,25). Conclusión. La prevalencia del bajo peso al nacer en el Hospital Carlos Showing Ferrari de Huánuco fue 6,2 %. La primiparidad, el inadecuado control prenatal y el parto pretérmino fueron los factores asociados.

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Li, Ji-Tao, Yu Feng, Yun-Ai Su, Xiao-Dong Wang und Tian-Mei Si. „Enhanced interaction among ErbB4, PSD-95 and NMDAR by chronic MK-801 treatment is associated with behavioral abnormalities“. Pharmacology Biochemistry and Behavior 108 (Juli 2013): 44–53. http://dx.doi.org/10.1016/j.pbb.2013.04.008.

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Zangue, Camille Teitsa, Justin Kouamo, Ferdinand Ngoula, Ludovic Pépin M’bapté Tawali, Mathias Mba Talla, Lionnel Yvan Kantchouet Mbeba, Claude Landry Makuetamang Doumtsop und Bernard Viban Tangwa. „Seroprevalence and Risks Factors Associated with Coxiella burnetii Infection in Slaughterhouse Zebu Cattle (Bos indicus) from Northern Regions of Cameroon“. Epidemiologia 3, Nr. 4 (06.10.2022): 434–42. http://dx.doi.org/10.3390/epidemiologia3040033.

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A study was conducted to determine the seroprevalence and risks factors of Coxiella burnetii in zebu cattle from the northern regions of Cameroon. From a total of 2016 (1754 females and 262 males) sera sampled, 801, 762 and 453 were collected, respectively, from Adamawa, North and Far North, and screened for Coxiella burnetii using indirect enzyme-linked immunosorbent assay (iELISA). A total of 23.76% (479/2016) were serologically positive. The seroprevalence of Adamawa, North and Far North were 29.09% (233/801), 19.95% (152/762) and 20.75% (94/453); respectively. The seropositivity of male and female were 4.58% and 26.62%; respectively. Cattle from Adamawa region were more likely to have been exposed to C. burnetii than animals from Far North region (OR = 3.28; 95%CI: 1.13–7.85; p = 0.02). The Gudali breed was significantly more infected than Aku (OR =2.52; 95%CI: 1.06–5.99; p = 0.03), and animals aged of (6–9) years were 1.89 times more likely to have been infected to C. burnetii than young animals (p = 0.03). The seropositivity to this bacterium was significantly associated to pregnant cattle than non-pregnant (OR = 1.71; 95%CI: 1.01–2.90; p = 0.04). Female cattle were more likely to have been infected by C. burnetii than male and the rainy season were 1.66 more associated to this disease than dry season. The linear regression model indicated that C. burnetii seropositivity were positively correlated to the regions (0.09, CI: 0.04; 0.18; p = 0.007), age (0.01, CI: −0.01; 0.04; p = 0.02), sex (0.19, CI: 0.08–0.32, p = 0.001) and physiological status (0.11, CI: −0.04; 0.26; p = 0.006). This study revealed that C. burnetii infection is widespread among zebu cattle of Adamawa, North and Far North of Cameroon.

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Richards, Kaitlyn, Ankit Kadakia, Charles C. Wykoff, James C. Major, Tien P. Wong, Eric Chen, Amy C. Schefler et al. „MANAGEMENT OF LARGE FULL-THICKNESS MACULAR HOLES“. Retina 44, Nr. 7 (Juli 2024): 1165–70. http://dx.doi.org/10.1097/iae.0000000000004099.

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Background/Purpose: To determine and compare the efficacy of a surgical internal limiting membrane (ILM) flap technique with the traditional ILM peel on long-term visual and anatomical outcomes for large (>400 µm) full-thickness macular holes. Methods: From October 2016 to July 2022, patients undergoing initial full-thickness macular hole repair with the ILM flap or ILM peel technique were reviewed. Final outcomes were recorded and based on size in microns: 401 to 800, 801 to 1,200, and >1,200. Results: Patients treated with ILM flap (n = 52, 94.2% closure rate) or ILM peel (n = 407, 93.6% closure rate) were followed with a mean follow-up time of 15.0 ± 10.2 and 20.0 ± 13.4 months, respectively. Success rates for ILM flaps and ILM peels were compared for full-thickness macular holes of 401 to 800 (100%, 95.8%, P = 0.39), 801 to 1,200 (95%, 93%, P = 0.74), and >1,200 (86.7%, 86.7%, P = 1.0) µm. Mean best-recorded logarithm of the minimal angle of resolution visual acuity for ILM flaps and ILM peels, respectively, was 1.02 ± 0.46 and 0.87 ± 0.47 preoperatively, with follow-up acuity of 0.48 ± 0.32 (P < 0.03) and 0.39 ± 0.42 (P < 0.01) at Year 3. Conclusion: Both techniques provide a similar anatomical closure rate and functional improvement in vision. Comparisons should be cautiously made based on difference in preoperative hole size.

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Bücher zum Thema "801/.95"

S, Baumlin James, Baumlin Tita French und Jensen George H, Hrsg. Post-Jungian criticism: Theory and practice. Albany: State University of New York Press, 2004.

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1961-, Ziarek Krzysztof, und Deane Seamus 1940-, Hrsg. Future crossings: Literature between philosophy and cultural studies. Evanston, Ill: Northwestern University Press, 2000.

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Eagleton, Terry. Marxism and Literary Criticism. London: Taylor & Francis Group Plc, 2004.

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Ann, Hohne Karen, und Wussow Helen, Hrsg. A Dialogue of voices: Feminist literary theory and Bakhtin. Minneapolis: University of Minnesota Press, 1994.

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Cultural criticism, literary theory, poststructuralism. New York: Columbia University Press, 1992.

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Deconstruction: Derrida. Basingstoke: Macmillan, 1998.

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Sexual/textual politics: Feminist literary theory. 2. Aufl. London: Routledge, 2002.

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Buchteile zum Thema "801/.95"

Albertini, Tamara. „Rābi‘a al-‘Adawiyya of Basra 712–801/185–95 رابعة ا عدوية ا بصرية“. In Women in the History of Philosophy and Sciences, 191–224. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-28563-9_10.

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Konferenzberichte zum Thema "801/.95"

Cooner, M. L., R. S. Reynolds und R. Srinivasan. „Application of Taguchi Optimization Techniques to the Combustor Design Process“. In ASME 1995 International Gas Turbine and Aeroengine Congress and Exposition. American Society of Mechanical Engineers, 1995. http://dx.doi.org/10.1115/95-gt-413.

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This paper describes the application of Taguchi design of experiments (DOE) methods to the initial development of the T800-LHT-801 growth engine combustor design. The performance of a gas turbine combustor is strongly influenced by the primary zone aerodynamics and stoichiometry. The interactions between fuel spray and airflows through swirlers, primary jets, and dome surface cooling dominate the primary zone characteristics. Development of a robust combustor design requires a good knowledge of the relative sensitivities of these interactions. In this application, the Taguchi DOE method was used to efficiently determine the design parameters driving the combustor performance, while minimizing the number of tests. The improved design configuration resulted in 60 percent reduction in Lean Blow Out (LBO), 140°C reduction in peak wall temperature, and elimination of carbon formation potential at severe operating conditions.

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