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Whittall, Ian R., Mark G. Humphrey und David C. R. Hockless. „Structural Systematics of Metal Acetylide Complexes: X-Ray Studies of Some 'Extended-Chain' Gold σ-Acetylide Complexes“. Australian Journal of Chemistry 50, Nr. 10 (1997): 991. http://dx.doi.org/10.1071/c97049.
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The structures of Au(4-C≡CC6H4XYC6H4-4′-NO2)(PPh3) (XY = (E )-CH=CH (1), (Z)-CH=CH (2), C≡C (3), N=CH (4)) have been determined by single-crystal X-ray diffraction analyses, refining by full-matrix least-squares analysis. For (1), crystals are triclinic, space group P-1, with a8·847(1), b 17·870(4), c 19·705(3) Å, α116·25(1), β 93·33(1), γ 92·64(2)˚, Z 4, 6747 unique reflections (703 parameters), converging at R 0·025 and Rw 0·029. For (2), crystals are monoclinic, space group P 21/a, with a 10·718(6), b 19·398(5), c14·469(3) Å, β 108·96(2)˚, Z 4, 3295 unique reflections (352 parameters), converging atR 0·040 and Rw 0·034. For (3), crystals are triclinic, space group P-1, with a 10·671(4), b 17·599(7), c 18·220(8) Å, α 116·31(3), β 105·00(4), γ 95·08(4)˚, Z 4, 4828 unique reflections (703 parameters), converging at R 0·043 and Rw 0·030. For (4), crystals are triclinic, space group P-1, with a 8·8314(6), b 17·834(2), c 20·001(2) Å, α 115·249(7), β 90·930(7), γ 94·082(7)˚, Z 4, 4724 unique reflections (703 parameters), converging at R 0·035 and Rw 0·034. Despite the [ligated metal donor]-bridge-[nitro acceptor] composition of these complexes, Au–C and C≡C distances are normal and consistent with minimal allenylidene contribution to the ground-state geometry. Within the 3σ confidence limits, the structural data do not provide evidence for π*-back-bonding in these complexes
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Cruz, Leonardo De la, Jorge Torres, Adrián Solano, Marcial Espinoza, Maria Neyra, Pablo Constantino, Jesús Aranzolo und Ricardo Sánchez. „Pneumatic gauge pressure comparison from 700 kPa to 7 000 kPa“. Metrologia 57, Nr. 1A (01.01.2020): 07024. http://dx.doi.org/10.1088/0026-1394/57/1a/07024.
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Manus, Jean-Marie. „Alerte au Sénat, 700 000 élèves en danger !“ Revue Francophone des Laboratoires 2022, Nr. 541 (April 2022): 22–23. http://dx.doi.org/10.1016/s1773-035x(22)00130-7.
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Brimble, Margaret A., Andrew Johnston, Trevor W. Hambley und Peter Turner. „Crystal Structures of (3S*,4S*,5S*,6S*)-3,4-Epoxy- 1,7-dioxaspiro[5.5]undecan-5-ol, (3R*,5S*,6S*)-1,7- Dioxaspiro[5.5]undecane-3,5-diyl Diacetate and (4S*,5S*,6S*)-1,7-Dioxaspiro[5.5]undecane-4,5-diol“. Australian Journal of Chemistry 50, Nr. 2 (1997): 123. http://dx.doi.org/10.1071/c96186.
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The structures of (3S*,4S*,5S*,6S*)-3,4-epoxy-1,7-dioxaspiro[5.5]undecan-5-ol (2), (3R*,5S*,6S*)-1,7- dioxaspiro[5.5]undecane-3,5-diyl diacetate (4) and (4S*,5S*,6S*)-1,7-dioxaspiro[5.5]undecane-4,5-diol (5) have been determined by X-ray crystallography. The unsubstituted tetrahydropyran ring in (2) adopts an axial position with respect to the epoxy-substituted ring and the hydroxy group at C5 is syn to the epoxide group. Intermolecular hydrogen bonding is observed between the C5 hydroxy group and O1. The two six-membered rings in (4) adopt chair conformations and the two acetate groups adopt 1,3-diaxial positions. The C5 hydroxy group in (5) assumes an axial position anti to the C-O bond of the neighbouring ring whilst 4-OH occupies an equatorial position. Intermolecular hydrogen bonding is also observed between 4-OH and 5-OH. Compound (2), C9H14O4, M 186·21, crystallized in the monoclinic space group P 21/c with a 7·867(1), b 12·2060(9), c 9·3676(8) Å, b 102·744(8), V 877·4(1) Å 3 and No 1163 [I > 2·5s (I)], R 0·031, Rw 0·035. Compound (4), C13H20O6, M 272·30, crystallized in the triclinic space group P 1 with a 9·902(1), b 11·0024(9), c 6·9183(5)Å, a 104·078(8), b 96·769(9), g 101·980(8), V 703·8(1) Å 3 , No 1657 [I > 2·5s(I)], R 0·047, Rw 0·044. Compound (5), C9H16O4, M 188·22, crystallized in the orthorhombic space group Pbca with a 25·504(3), b 8·909(2), c 8·038(2) Å, V 1826·4(5) QA 3 , No 1096 [I > 2·5s(I)], R 0·030, Rw 0·030.
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Rosen, Alan. „Australian psychiatry: coming of age?“ International Psychiatry 2, Nr. 10 (Oktober 2005): 15–17. http://dx.doi.org/10.1192/s1749367600007505.
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Australia, a vast continent of 7 700 000 km2(including the island state of Tasmania), is roughly the size of Western Europe or mainland USA, but with a population of only 20.2 million (2004 estimate), mainly concentrated in coastal areas.
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Hüthig, Stefanie. „Über 700 Aufgaben in einem Portal“. Bankfachklasse 42, Nr. 5-6 (Juni 2020): 6–7. http://dx.doi.org/10.1007/s35139-020-0189-7.
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Cervi, Laura. „Comunidades virtuales de viajeros: un caso de éxito“. Universitas, Nr. 30 (28.02.2019): 97–125. http://dx.doi.org/10.17163/uni.n30.2019.05.
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Este artículo se propone estudiar la comunidad italiana de viajeros on line Ho sempre voglia di partire que, en solo dos años de vida, cuenta con más de 540 000 seguidores, más de 7 000 000 de visitas por mes y 2 700 000 interacciones. El objetivo es describir las interacciones presentes en la comunidad para desvelar las razones por las cuales los usuarios participan, los beneficios, reales y simbólicos que obtienen, y poder comprender las razones del éxito. A través de una triangulación de métodos el artículo desvela como la clave de todas las interacciones es la emoción y que, por lo tanto, los beneficios que los miembros obtienen son principalmente emocionales.
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Gendron, Tracey, Camp Alyssa, Amateau Gigi, Mullen Mia, Jacobs Kristen, Jenny Inker und Sarah Marrs. „AGEISM IS NOT A CATCH-ALL: THE INTERRELATEDNESS OF AGEISM AND ABLEISM“. Innovation in Aging 7, Supplement_1 (01.12.2023): 364. http://dx.doi.org/10.1093/geroni/igad104.1208.
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Abstract Ageism represents discrimination based on age, while ableism represents discrimination toward people with disabilities. Given the natural occurrence of physical decline accompanying aging, it is essential to explore how prejudice toward disability intersects with fear about aging. 913 individuals responded to a survey on ageism and ableism. Multiple regression with internalized ageism as the criterion variable was significant F(7, 705) = 81.71, p <.001. Overall, the regression model explained 44.8% of the variance in internalized ageism with significance for age (t(705) = -5.45, p < .001), relational ageism (t(705) = 11.72, p < .001), affinity for older people (t(705) = -2.77, p = .006), ableism for physical disability (t(705) = 6.88, p < .001), and ableism for cognitive disability (t(705) = -2.86, p = .004), Multiple regression with relational ageism as the criterion variable was significant F(7, 705) = 88.12, p <.001. Overall, the regression model explained 46.7% of the variance in relational ageism with a significant for affinity for older people (t(705) = -3.80, p < .001), internalized ageism (t(705) = 11.72, p < .001), relational ableism (t(705) = 6.73, p < .001), ableism for cognitive disability (t(705) = 2.15, p = .007), and ableism for sensory disability (t(705) = -2.78, p = .006). Examining the intersection between ageism and ableism represents the next critical juncture to increasing our understanding of developing effective anti-ageism interventions that address the root anxieties influencing attitudes about aging.
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Ismi', Muhammad Ilham, Burhamtoro Burhamtoro und Muhamad Fajar Subkhan. „ANALISIS TEBAL PERKERASAN KAKU JALAN TOL SERANG – PANIMBANG DENGAN METODE BINA MARGA 2003 DAN AASHTO 1993 PADA STA. 0+000 – 7+700“. Jurnal JOS-MRK 2, Nr. 3 (20.09.2021): 150–55. http://dx.doi.org/10.55404/jos-mrk.2021.02.03.150-155.
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The Serang - Panimbang Toll Road is a means of supporting the Government's program to develop the Tanjung Lesung Special Economic Zone (KEK) which is one of the main priorities of the Committee for the Acceleration of Priority Infrastructure Provision (KPPIP) and for developing territorial potential by the local Regional Government. The Serang - Panimbang Toll Road will be connected to the Jakarta - Merak Toll Road. This study aims to analyze the thickness of the rigid pavement on the toll road using Bina Marga 2003 and AASHTO 1993 methods. The results obtained from this study are rigid pavement planning using a type of continuous cement concrete pavement without reinforcement. The results of the analysis of the concrete pavement calculation obtained a concrete plate thickness of 240 mm or 24 cm for the 2003 Bina Marga method, while for the 1993 AASHTO method a concrete plate thickness of 12.5 inches or 31.75 cm was obtained, with a sub-base layer on each method of 100 mm or 10 cm.
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Ogura, Atsushi, Tsuyoshi Konishi, Chris Cunningham, Julio Garcia-Aguilar, Henrik Iversen, Shigeo Toda, In Kyu Lee et al. „Neoadjuvant (Chemo)radiotherapy With Total Mesorectal Excision Only Is Not Sufficient to Prevent Lateral Local Recurrence in Enlarged Nodes: Results of the Multicenter Lateral Node Study of Patients With Low cT3/4 Rectal Cancer“. Journal of Clinical Oncology 37, Nr. 1 (01.01.2019): 33–43. http://dx.doi.org/10.1200/jco.18.00032.
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Purpose Improvements in magnetic resonance imaging (MRI), total mesorectal excision (TME) surgery, and the use of (chemo)radiotherapy ([C]RT) have improved local control of rectal cancer; however, we have been unable to eradicate local recurrence (LR). Even in the face of TME and negative resection margins (R0), a significant proportion of patients with enlarged lateral lymph nodes (LLNs) suffer from lateral LR (LLR). Japanese studies suggest that the addition of an LLN dissection (LLND) could reduce LLR. This multicenter pooled analysis aims to ascertain whether LLNs actually pose a problem and whether LLND results in fewer LLRs. Patients and Methods Data from 1,216 consecutive patients with cT3/T4 rectal cancers up to 8 cm from the anal verge who underwent surgery in a 5-year period were collected. LLND was performed in 142 patients (12%). MRIs were re-evaluated with a standardized protocol to assess LLN features. Results On pretreatment MRI, 703 patients (58%) had visible LLN, and 192 (16%) had a short axis of at least 7 mm. One hundred eight patients developed LR (5-year LR rate, 10.0%), of which 59 (54%) were LLRs (5-year LLR rate, 5.5%). After multivariable analyses, LLNs with a short axis of at least 7 mm resulted in a significantly higher risk of LLR (hazard ratio, 2.060; P = .045) compared with LLNs of less than 7 mm. In patients with LLNs at least 7 mm, (C)RT plus TME plus LLND resulted in a 5-year LLR of 5.7%, which was significantly lower than that in patients who underwent (C)RT plus TME (5-year LLR, 19.5%; P = .042). Conclusion LLR is still a significant problem after (C)RT plus TME in LLNs with a short axis at least 7 mm on pretreatment MRI. The addition of LLND results in a significantly lower LLR rate.
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Whybrow, Stephen, Graham W. Horgan und Jennie I. Macdiarmid. „Buying less and wasting less food. Changes in household food energy purchases, energy intakes and energy density between 2007 and 2012 with and without adjustment for food waste“. Public Health Nutrition 20, Nr. 7 (19.12.2016): 1248–56. http://dx.doi.org/10.1017/s1368980016003256.
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AbstractObjectiveConsumers in the UK responded to the rapid increases in food prices between 2007 and 2009 partly by reducing the amount of food energy bought. Household food and drink waste has also decreased since 2007. The present study explored the combined effects of reductions in food purchases and waste on estimated food energy intakes and dietary energy density.DesignThe amount of food energy purchased per adult equivalent was calculated from Kantar Worldpanel household food and drink purchase data for 2007 and 2012. Food energy intakes were estimated by adjusting purchase data for food and drink waste, using waste factors specific to the two years and scaled for household size.SettingScotland.SubjectsHouseholds in Scotland (n 2657 in 2007; n 2841 in 2012).ResultsThe amount of food energy purchased decreased between 2007 and 2012, from 8·6 to 8·2 MJ/adult equivalent per d (P<0·001). After accounting for the decrease in food waste, estimated food energy intake was not significantly different (7·3 and 7·2 MJ/adult equivalent per d for 2007 and 2012, respectively; P=0·186). Energy density of foods purchased increased slightly from 700 to 706 kJ/100 g (P=0·010).ConclusionsWhile consumers in Scotland reduced the amount of food energy that they purchased between 2007 and 2012, this was balanced by reductions in household food and drink waste over the same time, resulting in no significant change in net estimated energy intake of foods brought into the home.
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Rittmeier-Kettner, M., und G. M. Schneider. „Phase behaviour of neopentylglycol up to 700 MPa“. Thermochimica Acta 266 (November 1995): 185–87. http://dx.doi.org/10.1016/0040-6031(95)02441-7.
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Cannon, Joseph G. „Comprehensive Organic Functional Group Transformations Edited by A. R. Katritzky, O. Meth-Cohn, and C. W. Rees. Pergamon Press (Elsevier Science Ltd.), Tarrytown, NY. 1995. 7 vols., 19.5 × 28 cm. vol. 1, xix + 1420 pp; vol. 2, xix + 1441 pp; vol. 3, xix + 941 pp; vol. 4, xix + 1352 pp; vol. 5, xix + 1442 pp; vol. 6, xix + 933 pp; vol. 7, xvii + 1251 pp. ISBN 0-08-042-322-1; 0-08-042-323-X; 0-08-042-324-8; 0-08-0442-325-6; 0-08-042-326-4; 0-08-042-704-9; 0-08-042-705-7. $4310 (set).“ Journal of Medicinal Chemistry 40, Nr. 12 (Juni 1997): 1940. http://dx.doi.org/10.1021/jm970186l.
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Motcho, K. H. „Croissance urbaine et insécurité dans la ville de Niamey“. Geographica Helvetica 59, Nr. 3 (30.09.2004): 199–207. http://dx.doi.org/10.5194/gh-59-199-2004.
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Abstract. Née de la colonisation, la ville de Niamey comptait 1 730 habitants en 1931 et plus de 15 000 en 1953, soit une croissance annuelle de 7%. A partir de 1970, ce taux augmente pour atteindre 10%. En 1988, la capitale du Niger comptait 400 000 habitants. Aujourd'hui, eile en comporte près de 700 000. L'extension de la ville a été tout aussi rapide: en 1970, Niamey couvrait 1 367 ha, alors que sa superficie atteint plus de 10 000 ha aujourd'hui. Cette urbanisation galopante pose avec acuité des problèmes de sécurité. Vols à la tire, cambriolages et braquages, contre lesquels les quelques fonctionnaires de la police sont impuissants, fönt aujourd'hui partie du vécu des Niaméens. Cette insécurité grandissante est malheureusement le résultat de deux facteurs principaux qui sont intimement liés: la paupérisation grandissante de la population et la faiblesse du mode d'encadrement des jeunes. La délinquance juvénile prend de plus en plus d'ampleur, comme en témoigne le très grand nombre d'enfants de la rue qui, à l'occasion, commettent de petits larcins ou, au pire, sont les indicateurs des grands délinquants.
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Akilov, Kh A., N. T. Urmanov, F. Sh Primov, Jurat A. Djurayev und N. R. Xadjayarov. „EXPERIENCE IN TREATING ACUTE APPENDICITIS IN TASHKENT“. Russian Journal of Pediatric Surgery 23, Nr. 3 (12.07.2019): 157–60. http://dx.doi.org/10.18821/1560-9510-2019-23-3-157-160.
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75% of all emergency surgeries are surgeries for acute appendicitis. Annually, only in the Republican Scientific Center 700 appendectomies in children are made, in average. The article summarizes data obtained in the retrospective analysis of case histories of 6 256 patients with acute appendicitis and its complications who were hospitalized in the pediatric department of emergency surgery for 12 years. The following incidence of acute appendicitis in children is reported: from 1 to 3 years of age - 0.6 per 1 000; from 4 to 7-1.4-2.6 per 1 000; 13 years of age - 8 per 1 000. The authors discuss specific features in the clinical picture of acute appendicitis in children depending on patient’s age and anatomical location of the appendix. The clinical picture in children of older age and of the first three years of life is discussed separately. Out of 6 256 pediatric patients with acute appendicitis 72 (1.15%) were children younger than 3. The authors have substantiated a complex of diagnostic and therapeutic manipulations as well as tactic options to the treatment of this category of patients. Widespread implementation of the laparoscopic technique into surgical practice has significantly changed the tactics of treatment. The number of surgeries for simple appendicitis in children has decreased up to 3.9-7%.
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Silva, Marcos Pereira, Marília Evelyn Rodrigues Oliveira, Francisco Marcos Costa Batista, Maria Rita de Morais Chaves Santos, Maria Gardennia Fonseca und Edson Cavalcanti Silva Filho. „Organofunctionalization of Natural Palygorskite with Ethylene Sulfide in the Absence of a Solvent“. Materials Science Forum 869 (August 2016): 176–80. http://dx.doi.org/10.4028/www.scientific.net/msf.869.176.
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The search for functional materials has increased daily in order to improve their functionality while maintaining a low cost. Among the materials of considerable interest are clays and within them is a particular clay known as palygorskite, which contains a hydrated silicate of aluminum and magnesium with a fibrous morphology. This work achieved the organofunctionalization of palygorskite with ethylene sulfide in the absence of a solvent. Through the elemental analysis of sulphur, the incorporation of 9.73 ± 0.36 mmol g-1 was identified. A significant decrease in the crystallographic planes (110) and (040) was identified in the XRD. The FTIR showed vibrations of stretching and deformation of the methylene groups in the region below 3000 and in 1421 cm-1, respectively. The deformation related to the C-S group in the region of 700 and 600 cm-1, and the surface area (BET) showed a significant reduction from 113 to 7 m2 g-1. Additionally, the SEM presented a loss of fibrous character.
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Oleszczuk, Ryszard, Janusz Urbański und Monika Gąsowska. „The influence of morphological changes of small lowland river on discharge rate“. Annals of Warsaw University of Life Sciences, Land Reclamation 46, Nr. 4 (01.12.2014): 279–90. http://dx.doi.org/10.1515/sggw-2015-0002.
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Abstract The influence of morphological changes of small lowland river on discharge rate. The aim of the study was the comparison of the changes of cross-sections and longitudinal profile of the Mała river at the distance of 600 m. The paper presents the geometry changes of the river from field measurements made in 2013 in comparison with design assumptions from 1967 which were implemented in 1971. The four (available historical) cross-sections (hm 7+700, 7+800, 7+900, 8+000) and longitudinal profile (hm 7+700÷8+300) of the river were analysed and compared. The large scale of subsidence of the land surface on both banks was observed (even to 0.5 m). Probably it is the effect of peat shrinkage and mineralization processes of organic soils. The bottom of the Mała river was still located at the same altitude in sand deposits in the analysed period 1971-2013. The designed slope of bottom of the Mała river equals 0.7‰ (1967) and present slope (2013) was estimated to be around 1‰. The subsidence of peat layers on both river banks, changes in cross-sections’ parameters (present irregular shapes in comparison with designed trapezoidal cross-sections) caused the reduction of cross-sectional area and water discharge of about 40-50% in comparison with parameters designed in 1967 and made in 1971.
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Armstrong, D. G., C. O. McKay, D. J. Morrell und C. Goddard. „Insulin-like growth factor-I binding proteins in serum from the domestic fowl“. Journal of Endocrinology 120, Nr. 3 (März 1989): 373–78. http://dx.doi.org/10.1677/joe.0.1200373.
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ABSTRACT This investigation describes the presence of insulinlike growth factor-I (IGF-I) binding proteins in chicken serum. Whole blood was collected from broiler chickens of 7–9 weeks of age and analysed for binding proteins after gel permeation chromatography under both neutral and acidic conditions, and by polyacrylamide gel electrophoresis in the presence of 12·5% sodium dodecyl sulphate (SDS-PAGE). When serum was chromatographed under neutral conditions, about 70% of the IGF-I immunoreactivity was associated with a large protein complex (Mr=150 000) and 20–25% was associated with an intermediate-sized protein complex (Mr = 45 000). Up to 6% of the serum IGF-I immunoreactivity was eluted in a fraction which corresponded to an Mr of about 7500 and was presumably free IGF-I. Chromatography under acidic conditions dissociated the IGF-I/protein complexes and revealed the presence of an acid-stable binding protein (Mr = 50 000–60 000). After analysis of serum by SDS-PAGE, three monomeric IGF-I binding proteins (Mr = 28 800, 33 200 and 40 700) were detected. The largest monomer (Mr = 40 700) is probably the binding protein component of the intermediate-sized IGF-I/protein complex. The relationship between the other monomers and both the large IGF-I/protein complex and the acid-stable binding protein is not known. Although the pattern of binding proteins in chicken serum is similar to that observed in mammals, a major difference is the presence of up to 6% of the serum IGF-I immunoreactivity in an unbound form. Journal of Endocrinology (1989) 120, 373–378
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Effendy, John D. Kildea und Allan H. White. „Lewis-Base Adducts of Group 11 Metal(I) Compounds. LXVIII Synthesis and Structural Systematics of Some 1 : 3 Adducts of Silver(I) Compounds with Triphenylstibine, [(Ph3Sb)3AgX], X = Cl, I, SCN, NCS, CN, ONO2“. Australian Journal of Chemistry 50, Nr. 6 (1997): 587. http://dx.doi.org/10.1071/c96035.
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The syntheses and room-temperature single-crystal X-ray structural characterization of 1 : 3 adducts formed between silver(I) (pseudo-) halides, AgX, and triphenylstibine, SbPh3, are described for X = Cl, I, SCN, NCS, CN, NO3 (1)-(6). The chloride, as its methanol solvate (1a), is isomorphous with the arsine analogue: triclinic, P-1, a 13·373(4), b 14·48(6), c 14·702(3) Å, α 83·49(3), β 87·76(2), γ 76·45(3)°; Z = 2, conventional R on F being 0·046 for No 5514 independent ‘observed’ reflections (I > 3σ(I )). A new form (1b) of the chloride has also been authenticated: monoclinic, P 21/c, a 12·832(2), b 54·24(1), c 18·519(8) Å, β 129·68(3)°; Z = 8 (R 0·065 for No 5672). No bromide has been obtained; the iodide (2) is described as monoclinic, P 21/n, a 19·611(4), b 14·473(6), c 17·74(1) Å, β 98·28(3)°; Z = 4 (R 0·036 for No 6769). The thiocyanate crystallizes from acetonitrile or pyridine as an S-bonded form (3) isomorphous with the arsine analogue: monoclinic, P 21/n, a 19·143(7), b 14·288(5), c 18·694(6) Å, β 98·81(2)°; Z = 4 (R 0·037 for No 4482). From 2-methylpyridine, remarkably, a solvate is obtained in which the thiocyanate is N-bonded (4): triclinic, P-1, a 27·261(5), b 14·767(3), c 13·319(1) Å, α 91·53(1), β 101·58(1), γ 92·29(2)°; Z = 4 (R 0·045 for No 6900). The cyanide is also monoclinic, P 21/n, a 19·442(7), b 14·267(3), c 17·741(6) Å, β 97·63(3)°, z = 4; R 0·057 for No 2487. The unsolvated 1 : 3 nitrate complex (6a) is monoclinic, P 21/n, a 19·602(5), b 14·455(1), c 17·727(2) Å, β 97·19(2)°, Z = 4; R was 0·034 for No 6522. The complex is isomorphous with the arsenic and phosphorus analogues, being mononuclear [(Ph3Sb)3Ag(O2NO)]. The ethanol solvate (6b) is triclinic, P-1, a 13·352(5), b 14·548(9), c 14·701(4) Å, α 81·64(4), β 84·45(3), γ 75·32(4)°, Z = 2; R was 0·058 for No 4702. Ag-Sb range between 2·6980(8) and 2·843(3) Å in the precise determinations; Ag-X are 2·481(4) and 2·52(1) Å (the two chlorides), 2·757(1) (I), 2·533(3) (SCN), 2·21(1) (NCS), 2· 09(3) (CN), 2·377(7) Å (unidentate ONO2)
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Roberts, Spencer S. H., Emma Falkenberg, Alysha Stevens, Brad Aisbett, Michele Lastella und Dominique Condo. „The Sleep of Elite Australian Rules Footballers During Preseason: A Comparison of Men and Women“. International Journal of Sports Physiology and Performance 16, Nr. 5 (01.05.2021): 641–46. http://dx.doi.org/10.1123/ijspp.2020-0340.
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Purpose: Australian football has elite men’s (Australian Football League; AFL) and women’s (Australian Football League Women’s; AFLW) competitions. This study compared AFL and AFLW players’ sleep and characterized players’ sleep in the context of current sleep recommendations. Methods: A total of 70 players (36 AFL, 34 AFLW) had their sleep monitored via actigraphy over a 10-day preseason period. Sleep outcomes and their intraindividual variation, were compared between AFL and AFLW players using linear mixed models. Proportions of players sleeping ≥7 and ≥8 hours per night, and achieving ≥85% sleep efficiency, were compared using chi-square analyses. Results: Compared with AFL players, AFLW players slept less (7.9 [0.5] vs 7.1 [0.6] h, P = .000), had lower sleep efficiency (89.5% [2.8%] vs 84.0% [4.4%], P = .000), and greater intraindividual variation in sleep efficiency (3.1% [0.9%] vs 5.1% [2.1%], P = .000). A total of 47% of AFLW versus 3% of AFL players averaged <7 hours sleep (χ2 = 18.6, P = .000). A total of 88% of AFLW versus 50% of AFL players averaged <8 hours sleep (χ2 = 11.9, P = .001). A total of 53% of AFLW versus 14% of AFL players averaged <85% sleep efficiency (χ2 = 12.1, P = .001). Conclusions: AFLW players slept less and had poorer sleep quality than AFL players. Many AFLW players do not meet current sleep duration or sleep quality recommendations. Research should test strategies to improve sleep among Australian rules footballers, particularly among elite women.
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Gimingham, C. H. „Worldwide Fund For Nature, 1989. WWF Conservation Yearbook 1987/88. WWF Information and Education Division, Switzerland. 701 pages. ISBN 2-88085-020-7. Price: £16.00.“ Journal of Tropical Ecology 6, Nr. 3 (August 1990): 383–84. http://dx.doi.org/10.1017/s0266467400004715.
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Kim, Eun Young, Kyu Man Shin, Soyong Jang und Seikwan Oh. „Changes of [3H]Muscimol, [3H]Flunitrazepam and [3H]MK-801 Binding in Rat Brain by Prolonged Ventricular Infusion of 7-Nitroindazole“. Neurochemical Research 29, Nr. 12 (Dezember 2004): 2221–29. http://dx.doi.org/10.1007/s11064-004-7029-z.
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Casillas-Berumen, Sergio, Florencia A. Rojas-Miguez, Alik Farber, Sevan Komshian, Jeffrey A. Kalish, Denis Rybin, Gheorghe Doros und Jeffrey J. Siracuse. „Patient and Aneurysm Characteristics Predicting Prolonged Length of Stay After Elective Open AAA Repair in the Endovascular Era“. Vascular and Endovascular Surgery 52, Nr. 1 (09.11.2017): 5–10. http://dx.doi.org/10.1177/1538574417739747.
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Introduction: Open aortic aneurysm repair (AAA) repair can be resource intensive and associated with a prolonged length of stay (LOS). We sought to examine patient and aneurysm predictors of prolonged LOS to better identify those at risk in the preoperative setting. Methods: Patient data were obtained from the targeted AAA American College of Surgery National Surgical Quality Improvement Program database from 2012 to 2014 of patients undergoing open AAA repair. Multivariable logistic regression was used to determine predictors of prolonged postoperative LOS defined as greater than 10 days (75th percentile). Results: There were 1172 open AAA repairs identified. The majority (54%) of patients were older than 70 years and male (74%). Surgical approach was transperitoneal (70.9%) and retroperitoneal (29.1%). Aneurysms were 51.4% infrarenal, 33% juxtarenal, 5.7% pararenal, 7.4% suprarenal, and 2.5% type IV thoracoabdominal. Mean and median LOS were 9.1 ± 7.4 and 7 (0-72) days, respectively. Independently associated with extended LOS factors were visceral revascularization (odds ratio [OR]: 5.32, 95% confidence interval [CI]: 2.77-10.22, P < .001), type IV thoracoabdominal extent (OR: 3.09, 95% CI: 1.01-9.46, P = .048), suprarenal extent (OR: 1.89, 95% CI: 1.07-3.34, P = .029) and juxtarenal (OR: 1.43, 95% CI: 1.01-2.02, P = .004), non-Caucasian race (OR: 2.80, 95% CI: 1.77-4.41, P < .001), chronic obstructive pulmonary disease (OR: 1.76, 95% CI: 1.20-2.59, P = .004), not-from-home admission (OR: 1.91, 95% CI: 1.13-3.24), and age greater than 70 (OR: 1.49, 95% CI: 1.08-2.05, P = .014). Conclusion: We identified patient and aneurysm characteristics independently associated with protracted LOS following open AAA repair. Prospective identification of high-risk patients may allow physicians and hospitals to engage in multidisciplinary collaborations preoperatively to try to improve LOS in this resource-intensive population.
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Vega Sevilla, L. F., M. A. Villarreal-Alarcón, D. P. Flores-Gutierrez, N. De Avila Gonzalez, I. D. J. Hernandez-Galarza, J. A. Cardenas-de la Garza und D. Á. Galarza-Delgado. „POS0798-HPR PREVALENCE OF RISK FOR ANXIETY AND DEPRESSION IN PATIENTS WITH RHEUMATIC DISEASES“. Annals of the Rheumatic Diseases 82, Suppl 1 (30.05.2023): 692.2–693. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2788.
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BackgroundPatients with chronic diseases have a higher prevalence of anxiety and depression. The complex relationship between chronic diseases and mental health disorders can influence each other negatively. (1)ObjectivesTo determine anxiety and depression symptoms prevalence in an out-patient rheumatology clinic, and its associated factors.MethodsThis was a cross-sectional study. Patients > 16 years old with a rheumatologic disease were included. Data from medical history were collected. The Hospital Anxiety and Depression Scale (HADS) was applied from March to November 2022. A score from 0-7 points is classified as low risk, 8-10 as intermediate risk, and >11 as high risk. Patients with high risk were referred to an evaluation by Psychiatry in the same clinic. We compared groups according to HADS scores using Kruskal-Wallis or Chi-square test.ResultsA total of 705 patients were included, 658 women, demographic characteristics in Table 1. Most common diagnosis was RA, followed by systemic lupus erythematosus (SLE). High anxiety risk was found in 125 patients, median disease duration of 6 years. Sixteen patients had high risk for depression, median disease duration of 10 years. Intermediate risk of depression was assessed in 15 patients, median disease duration of 10 years. We received 38 patients that accepted to be referred to a psychiatric evaluation. An association was found between high risk of anxiety and gender (p=0.019), no association was found with age or menopause. High risk of anxiety was more prevalent (n=125) than depression (n=16), and patients with intermediate risk for depression showed a higher prevalence of intermediate and high risk for anxiety (p=.000).ConclusionWe found that high risk of anxiety was more prevalent than depression. Higher risk of anxiety was found in female patients. Almost 1 of every 5 patients with rheumatic diseases has an intermediate risk for anxiety. The implementation of a mental health screening tool can help patients receive earlier attention by a specialist.References[1]Hayward G, Mandela R, Barr A, Freeston J, Vandevelde C, Marzo-Ortega H. Counselling services embedded within rheumatology clinics could help bridge the gap in mental health care provision for adults with rheumatic diseases. Rheumatol Adv Pract. 2022;6(3):rkac080.[2]Maldonado G, Ríos C, Paredes C, Ferro C, Intriago MJ, Aguirre C, et al. Depression in Rheumatoid Arthritis. Revista Colombiana de Reumatología (English Edition). 2017;24(2):84-91.Table 1.Demographic, clinical and rheumatic disease characteristics.CharacteristicsHADS A lowHADS A interHADS A highpHADS D lowHADS D interHADS D highp(n= 477)(n=103)(n=125)(n= 674)(n=15)(n=16)Age, years, median (iQR)51.0 (42.5-61.0)51.0 (45.0-61.0)56.0 (45.0-64.0)NS52.0 (43.0-61.0)60.0 (38.0-63.0)59.5 (40.5-69.0)NSWomen, n (%)437 (91.6)98 (95.1)123 (98.4)0.019628 (93.1)98 (100)15 (93.7)NSDisease duration, years, mean5.0 (1.0-10.0)4.0 (1.00-10.0)6.0 (2.25-12.0)NS5.0 (1.0-10.0)10.0 (1.00-20.0)10.0 (4.25-20.0)NSAge of diagnose, years, median (iQR)45 (32.0-53.5)45.9 (35.0-54.0)48.0 (37.0-56.7)NS45.0 (33.5-54.0)45.0 (31.0-59.0)47.0 (28.3-58.5)NSComorbidities, #, median (iQR)0.0 (0.0-1.0)0.0 (0.0-1.0)0.0 (0.0-1.0)NS0.0 (0.0-1.0)1.0 (0.0-1.0)1.0 (0.0-1.0)NSRA, n (%)249 (52.2)52 (50.4)53 (42.4)NS341 (50.5)6 (40.0)7 (43.7)NSLES, n (%)67 (14.0)12 (11.6)15 (12.0)89 (13.2)1 (6.6)4 (25.0)FM, n (%)14 (2.9)2 (1.9)3 (2.4)18 (2.6)1 (6.6)0 (0)SS, n (%)10 (2.0)4 (3.8)5 (4.0)18 (2.6)1 (6.6)0 (0)SCLERODERMA, n (%)10 (2.0)2 (1.9)1 (0.8)12 (1.7)1 (6.6)0 (0)OP, n (%)15 (3.1)2 (1.9)7 (5.6)22 (3.2)1 (6.6)1 (6.2)Overlap, n (%)31 (6.4)10 (9.7)21 (16.8)57 (8.4)3 (20.0)2 (12.5)Other, n (%)81 (16.9)19 (18.4)19 (15.2)116 (17.2)1 (6.6)2 (12.5)iQR interquartile range, RA reumathoid arthritis, SLE systemic lupus erytemathosus, FM fibromyalgia, SS Sjogren´s syndrome, OP osteopeniaDisclosure of InterestsNone Declared.
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Fang, Xuan, Xiao-Wei Liu und Peter J. Storey. „Very deep spectroscopy of the bright Saturn nebula NGC 7009: The optical recombination spectrum and new effective recombination coefficients“. Proceedings of the International Astronomical Union 7, S283 (Juli 2011): 354–55. http://dx.doi.org/10.1017/s1743921312011398.
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AbstractWe present very deep spectroscopic observations of the rich optical recombination line (ORL) spectrum of the bright Saturn nebula NGC 7009. Detailed spectral analyses, combined with systematic emission line identifications, in the whole optical range (3040–11 000 Å) give more than 1000 emission lines, over 80% of which are ORLs. New calculations of the N ii effective recombination coefficients in intermediate coupling scheme are carried out. These N ii atomic data, together with the most recent O ii and Ne ii effective recombination coefficients, are utilized in the spectral analyses of NGC 7009. Departure from LS coupling is noticed. Agreement is found between the observed and predicted relative intensities of ORLs. The elemental abundances of C, N, O, and Ne deduced from ORLs are systematically higher than those from collisionally excited lines (CELs) by a factor of 5–7.
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Nieminen, Mauri. „Ennen poro ruokki poromiehen, nyt poromies ruokkii poron“. Suomen Maataloustieteellisen Seuran Tiedote, Nr. 33 (31.01.2016): 1–7. http://dx.doi.org/10.33354/smst.75214.
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Suomessa poronomistajia on enää 4 000 ja alle 900 pitää porotaloutta elinkeinonaan. Ylä-Lapin kankailla jäkälämäärä pieneni 30 vuodessa 75 %, ja sitä on enää 120 kg kuivapainoa/ha. Poronhoitoalueen keski ja eteläosassa jäkälää on vain 35 kg/ha. Määrät ovat 10-100 kertaa pienemmät kuin metsäpeuroilla Kuhmossa sekä tunturipeuroilla ja poroilla Etelä-Norjassa ja Kuolassa. Vaikka tunturialueesta on suojeltu yli 80 %, myös tunturikoivikot ovat ylilaidunnettuja ja uhanalaisia. Poroja ruokitaan talvisin kaikissa paliskunnissa ja yli 45 miljoonalla rehukilolla. Rehuista yli puolet on kaupallisia, ja säilörehua tuodaan myös poron oitoalueen ulkopuolelta. Tällä rehumäärällä Suomen noin 200 000 eloporoa elää yli neljä kuukautta. Laitumiltaan kaksi kertaa suuremman Sallan paliskunnan poronhoito poikkeaa suuresti samassa kunnassa sijaitsevasta Pohjois-Sallasta. Kesälaitumia on kolme kertaa enemmän mutta jäkälää erittäin vähän. Eloporotiheys on siellä kaksi kertaa pienempi kuin Pohjois-Sallassa mutta talviruokinta on yleistä. Ruokintakulut olivat tutkimusvuosina 2005-13 Sallassa noin kuusi kertaa suuremmat kuin Pohjois-Sallassa, jossa poroja on ruokittu vähän vain paliskunnan eteläosassa. Sallassa poroelinkeinon tulos ilman peto ja liikennevahinkokorvauksia sekä maataloustukia oli suurista ruokintakuluista johtuen negatiivinen, keskimäärin jopa 6 000 euroa/poronomistaja. Ruokinta ja kesyyntyminen ovat tuoneet Sallassa poroja taajamiin, pihoille, pelloille ja teille lisäten liikennevahinkoja. Vahinkokorvaukset nostivat hieman kokonaistulosta, ja maataloustukien myötä se oli yli 7 000 euroa/poronomistaja. Pohjois-Sallassa lähes kaikki poronomistajat saivat puolestaan petokorvauksia ja paliskunta myös vasahävikkikorvausta. Keskimääräinen petovahinkokorvaus kasvoi nelinkertaisesti laskeviin myyntituloihin verrattuna. Poroelinkeinon tulos oli ilman petokorvauksia ja maataloustukia 2 000-7 700 euroa/poronomistaja. Kokonaistulos kasvoi nopeasti ja suuresti petovahinkokorvausten myötä, ja se oli lopulta keskimäärin yli 15 000 euroa/poronomistaja. Kokonaistulos oli Pohjois-Sallan poronomistajilla ja pääasiassa luonnonlaitumilla yli kaksi kertaa suurempi kuin Sallassa. Veroja maksoi molemmissa paliskunnissa vuosittain vain muutama poronomistaja. Tutkimustulosten mukaan poroja pitäisi hoitaa paremman kannattavuuden, mutta myös hyvän imagon vuoksi enemmän luonnonlaitumilla. Porolaidunten riittävyyteen, kuntoon ja poromääriin pitäisi kiinnittää huomiota jo kasvavien liikenne ja petovahinkojen vuoksi koko poronhoitoalueella.
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Lai, Shaoqing, Fenghuan Ju, Guiqi Wang, Shun He, Xiaoguang Ni, Lei Zhang, Guixiang Yu, Yueming Zhang und Xiaoyan Li. „The clinical epidemiological characteristics of 704 cases of colorectal cancer from 2004–2008“. Chinese-German Journal of Clinical Oncology 9, Nr. 6 (Juni 2010): 327–29. http://dx.doi.org/10.1007/s10330-010-0612-7.
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Bouchelle, Zoe, Aditi Vasan, Molly Candon und Chén C. Kenyon. „Food Insufficiency Following Discontinuation of Monthly Child Tax Credit Payments Among Lower-Income US Households“. JAMA Health Forum 3, Nr. 11 (11.11.2022): e224039. http://dx.doi.org/10.1001/jamahealthforum.2022.4039.
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ImportanceThe 2021 expanded Child Tax Credit provided advance monthly payments to many US families with children from July through December 2021 and was associated with a reduction in food insufficiency. Less is known about the effect of the discontinuation of monthly payments.ObjectiveTo assess whether the discontinuation of monthly Child Tax Credit payments was associated with subsequent changes in food insufficiency among lower-income US households with children.Design, Setting, and ParticipantsThis population-based cross-sectional study used data from the Household Pulse Survey, a recurring online survey of US households conducted by the US Census Bureau, from January 2021 to March 2022. This study estimated difference-in-differences regression models for households making less than $50 000, less than $35 000, and less than $25 000 annually, adjusting for demographic characteristics and state of residence. The estimation sample of households making less than $50 000/y included 114 705 responses, representing a weighted population size of 27 342 296 households.ExposuresReceipt of monthly Child Tax Credit payments, as measured by living in a household with children during the period of monthly payments from July through December 2021.Main Outcomes and MeasuresHousehold food insufficiency, as measured by a respondent indicating that there was sometimes or often not enough food to eat in the household in the previous 7 days.ResultsAmong 114 705 households making less than $50 000/y, respondents were predominantly female (57%); White (71%); not of Hispanic, Latino, or Spanish origin (79%); had high school or equivalent education (38%); and were unmarried (70%). Following the discontinuation of monthly Child Tax Credit payments, food insufficiency in US households with children increased by 3.5 percentage points (95% CI, 1.4-5.7 percentage points) among households making less than $50 000/y, 4.9 percentage points (95% CI, 2.6-7.3 percentage points) among households making less than $35 000/y, and 6.2 percentage points (95% CI, 3.3-9.3 percentage points) among households making less than $25 000/y. These estimates represent a relative increase in food insufficiency of approximately 16.7% among households making less than $50 000/y, 20.8% among households making less than $35 000/y, and 23.2% among households making less than $25 000/y.Conclusions and RelevanceIn this population-based cross-sectional study, discontinuation of monthly Child Tax Credit payments in December 2021 was associated with a statistically significant increase in household food insufficiency among lower-income households, with the greatest increase occurring in the lowest-income households.
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Millar, Colin. „A. Erkkila & H. Siiskonen 1992. Forestry in Namibia 1850–1990. University of Joensuu, Finland. 244 pages. ISBN 951-708-010-7. Price: US $45.00 (hardback).“ Journal of Tropical Ecology 11, Nr. 1 (Februar 1995): 153–54. http://dx.doi.org/10.1017/s026646740000852x.
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Nadeem, Muhammad, Naomi Galili, Muhammad Mumtaz, Peter Daya, Jason Cheskis und Azra Raza. „Survival Analysis of Myelodysplastic Syndrome (MDS) Patients with Abnormal Karyotype - A Single Group Experience“. Blood 120, Nr. 21 (16.11.2012): 4952. http://dx.doi.org/10.1182/blood.v120.21.4952.4952.
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Abstract Abstract 4952 Introduction: MDS are a heterogeneous group of hematologic disorders associated with clonal evolution of abnormal erythroid, myeloid and megakaryocytic lineages. Risk of transformation to acute myeloid leukemia (AML) is determined by IPSS score. Common chromosomal aberrations include abnormalities of 5, 7, 8, 20 and Y. The present survival analysis is unique in that only one team of experts was involved in diagnosis and management of these patients over more than two decades. Material and Methods: Data of patients with abnormal karyotype either at first presentation or during the course of MDS was collected retroactively. FAB, IPSS and WHO classification were used. Dates of death were retrieved from social security death index. Statistical analyses were performed by using SPSS version 18. Results: Of 709 patients with abnormal karyotypes, 292(41%) were classified as RA (or refractory cytopenias), 80 (11%) RARS, 253(36%) RAEB, 45(6%) CMMoL and 34(5%) RAEB-t and 5 (1%) were unclassified. There were 271 (37%) females and 438 (63%) males with a median age of 67 yrs and 68 yrs respectively. The most frequent abnormalities affected chromosome 5 (279 or 40%); del5q/-5 with other changes was seen in 233 (83. 5 %) and isolated del5q/-5 in 79 (28. 3%). Chromosome 7 abnormalities were found in 181 (25. 5%) patients with 38 (21%) having isolated del7q/-7. Chromosomal 8 abnormality was seen in 174 (24. 5%) patients and 71 (41%) had isolated trisomy 8. Other frequently involved chromosomes were 20 and Y affecting 158 (22. 3%) and 55 (7. 8%) patients respectively. Complex karyotype with 3 or more chromosomal aberrations was seen in 201 (28. 3%) patients. Data on 700 patients was available for analysis when all chromosomal aberrations were considered according to various IPSS risk categories. The median survival was 73 months for low risk (74 patients), 33. 7 months for int-1 (303 patients), 13 months for int-2 (227 patients) and 11. 5 months for high risk (96 patients) (p=0. 000) groups. By cytogenetic abnormalities, the best median survival of 82 months (39/229) was seen in patients with del5q/-5 and low risk disease. Other risk groups with de5q/-5 showed 32, 11 and 9 months in int-1, int-2 and high risk disease respectively (p=<0. 05). The worst median survival was in patients with high risk disease and del7q/-7 (7. 4 months, 33/127) and in patients with complex karyotype (8 months, 55/197). Conclusion: Deletion 5q patients show the best median survival among low and int-1 risk groups. Our data show considerable improvement in median survival of high risk patients compared to the earlier reported survival (11. 5 versus 4 months) which probably reflects improvement due to the use of hypomethylating agents. This improvement in survival gains more significance when considering the fact that we have used the data of only those patients with chromosomal aberrations. Disclosures: No relevant conflicts of interest to declare.
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Yarantseva, S. В., M. A. Shishkina und L. D. Gerasimchuk. „New breed of dairy cattle Sibiryachka“. Siberian Herald of Agricultural Science 49, Nr. 6 (29.01.2020): 62–70. http://dx.doi.org/10.26898/0370-8799-2019-6-7.
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Based on the use of the best domestic and world gene pool of the Holstein breed, a domestic highly productive breed of cattle with a genetic potential of more than 10 000 kg of milk per lactation adapted to the climatic conditions of Siberia was created. When breeding it, different reproductive crosses were used. As a result, a competitive livestock breed with a population of 26 770 heads was obtained. The productivity of 10 129 cows at the time of breed testing averaged 7,461 kg of milk with a fat content of 3.78% and a protein content of 3.16%. In terms of milk yield and protein content in milk, they surpass Black-and-White cows by 1,460 kg and 0.05%, respectively. However, the animals of the original breed have a higher fat content of milk, by 0.14%. The live weight of cows of Sibiryachka breed is 36 kg (6%) more than that of Black-and-White cows. Young animals of the new breed are intensively growing and developing. At all ages, their live weight is higher than Black-and-White peers. The average daily increase from birth to one year for heifers of the new breed was 770 g, for Black-and-White peers – 700 g. For a growing period of up to 18 months, daily growth averaged 706 and 673 g, respectively. The live weight of heifers at 18 months is 424 kg, Black-and-White – 405 kg, which allows insemination of heifers of Sibiryachka breed 24 days earlier. The average yield of calves over 3 years in the new breed was 82.7%, in the original one it was 3.7% less. The period of use of the cows of the created breed is 3.47 calving, which is 8% more compared to the Black-and-White breed.
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Mena-Vázquez, N., C. M. Romero-Barco, M. Rojas-Giménez, R. Redondo, I. Ureña, I. Añón Oñate, P. Morales-Garrido et al. „POS0886 EFFICACY AND SAFETY OF RITUXIMAB IN AUTOIMMUNE DISEASE–ASSOCIATED INTERSTITIAL LUNG DISEASE: A PROSPECTIVE COHORT STUDY.“ Annals of the Rheumatic Diseases 81, Suppl 1 (23.05.2022): 739–40. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3014.
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BackgroundInterstitial lung disease (ILD) is a common condition in patients with connective tissue disease (CTD). It is associated with increased morbidity and mortality. Rituximab (RTX) has been approved for treatment of RA and some recent retrospective studies suggest that it could be an alternative treatment for patients with CTD-ILD, even in cases that prove refractory to conventional immunosuppressants.ObjectivesTo analyze the efficacy and safety of RTX in connective tissue disease associated with interstitial lung disease (CTD-ILD).MethodsWe performed a multicenter, prospective, observational study of patients with CTD-ILD receiving RTX between 2015 and 2020. Patients who had worsening of respiratory symptoms or decline in the pulmonary function tests (PFT) compared to the time of ILD diagnosis were treated with rituximab. The patients were assessed using high-resolution computed tomography and PFT baseline, at 12 months, and at the end of follow-up. The main outcome measure at the end of follow-up was forced vital capacity (FVC)>10% or diffusing capacity of the lungs for carbon monoxide (DLCO)>15% and radiological progression or death. We recorded clinical characteristics, time to initiation of RTX, concomitant treatment, infections, and hospitalization. A Cox regression analysis was performed to identify factors associated with worsening of ILD.ResultsWe included 37 patients with CTD-ILD treated with RTX for a median (IQR) of 38.2 (17.7-69.0) months (Table 1). At the end of the follow-up, disease had improved or stabilized in 23 patients (62.1%) and worsened in 7 (18.9%); 7 patients (18.9%) died. Mean PFT values decreased significantly at the start of RTX compared to the date of ILD diagnosis in FVC (72.2[21.3]vs 73.5 [16.9] mg/l;p=0.040) and DLCO-SB (55.9 [15.7] vs 58.3 [16.1] mg/l; p=0.041). No significant decline was observed in median FVC (72.2 vs 70.8; p=0.530) or DLCO (55.9 vs 52.2; p=0.100). The multivariate analysis showed the independent predictors for worsening of CTD-ILD to be baseline DLCO (OR [95% CI], 0.904 [0.8-0.9]; p=0.015), time to initiation of RTX (1.01 [1.001-1.02]; p=0.029), and mycophenolate (0.202 [0.04-0.8]; p=0.034). The infection incidence rate was 0.21 patient-years.Table 1.Baseline demographic and clinical characteristics of 37 patients with CTD-ILD receiving rituximab.VariableTotal n=37RAn=19SSn=14IMn=4p ValueFemale sex, n (%)27 (73.0)13 (68.4)11 (78.6)3 (75.0)0.806Age in years, mean (SD)62.8 (9.9)67.7 (9.7)57.9 (7.9)56.6 (5.5)0.001Smoking0.147Never smoked, n (%)20 (54.1)9 (47.4)7 (50.0)4 (100.0)Smoked at some time, n (%)17 (45.9)10 (52.6)7 (50.0)0 (0.0)Duration of CTD, months, median (IQR)107.8 (49.5-188.8)151.0 (8.,0-240.5)89.6 (51.3-184.4)35.1 (25.1-49.0)0.017Duration of ILD, months, median (IQR)65.4 (31.1-110.3)82.2 (37.4-120.1)64.5 (35.5-107.1)25.9 (25.0-36.0)0.136Time to initiation of RTX, median (IRQ)12.0 (6.5-48.2)25.1 (7.0-57.6)11.4 (3.9-43.6)7.4 (7.0-10.4)0.455Duration of treatment with RTX, median (IQR)38.2 (23.4-69.9)45.3 (22.2-79.9)52.5 (24.7-63.3)22.8 (17.7-36.2)0.291Combined with csDMARDs, n (%)15 (40.5)9 (47.4)5 (35.7)1 (25.0)0.637Methotrexate, n (%)5 (13.5)2 (10.5)3 (21.4)0 (0.0)0.468Leflunomide, n (%)2 (5.4)2 (10.5)0 (0.0)0 (0.0)0.367Sulfasalazine, n (%)1 (2.7)1 (5.3)0 (0.0)0 (0.0)0.615Hydroxychloroquine, n (%)7 (18.9)4 (21.1)2 (14.3)1 (25.0)0.840Combination with immunosuppressants, n (%)20 (54.1)7 (36.8)9 (64.3)4 (100.0)0.044Mycophenolate, n (%)19 (51.4)6 (31.6)9 (64.3)4 (100.0)0.021Azathioprine, n (%)1 (2.7)1 (5.3)0 (0.0)0 (0.0)0.615Corticosteroids, n (%)25 (67.6)14 (73.7)7 (50.0)4 (100.0)0.121Doses of corticosteroids, median (IQR)5.0 (0.0-10.0)5.0 (0.0-10.0)2.5 (0.0-7.5)10.0 (8.1-10.5)0.519ConclusionLung function improved or stabilized in more than half of patients with CTD-ILD treated with RTX. No significant increase in infection rates was observed. Early treatment and combination with mycophenolate could reduce the risk of progression of ILD.Disclosure of InterestsNone declared
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Choe, Young June, Young-Joon Park, Eun-Young Kim, Myoungyoun Jo, Eun Young Cho, Hyunju Lee, Yun-Kyung Kim, Yae-Jean Kim und Eun Hwa Choi. „SARS-CoV-2 transmission in schools in Korea: nationwide cohort study“. Archives of Disease in Childhood 107, Nr. 3 (02.12.2021): e20-e20. http://dx.doi.org/10.1136/archdischild-2021-322355.
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ObjectiveThere is an urgent public need to readdress the school closure strategies. We aimed to describe the epidemiology of COVID-19 in schools and school-aged children to understand their roles in transmitting SARS-CoV-2 in Korea.DesignRetrospective cohort study.SettingAll schools in KoreaPatientsAll school-aged children in Korea.InterventionsNone (observational study).Main outcome measuresIncidence rate, proportion of affected schools.ResultsBetween February and December 2020, the incidence rate was lower among school-aged children (63.2–79.8 per 100 000) compared with adults aged 19 and above (130.4 per 100 000). Household was the main route of transmission (62.3%), followed by community (21.3%) and school clusters (7.9%). Among the schools in Korea, 52% of secondary schools had COVID-19 cases, followed by 39% of primary schools and 3% of kindergartens.ConclusionsWe found that schools and school-aged children aged 7–18 years were not the main drivers of COVID-19 transmission. The major sources of transmission were households.
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Önal, ArmaĞan. „A Highly Sensitive Spectrofluorometric Method for the Determination of a New Antidepressant Drug, Reboxetine, in Tablets“. Journal of AOAC INTERNATIONAL 89, Nr. 4 (01.07.2006): 972–75. http://dx.doi.org/10.1093/jaoac/89.4.972.
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Abstract A highly sensitive, selective, and rapid spectrofluorometric method has been developed for the determination of reboxetine (REB) in tablets. The method is based on derivatization with 7-chloro-4-nitrobenzofurazan. The product showed an absorption maximum at 476 nm and a fluorescence emission peak at 533 nm in ethyl acetate. The optimum conditions of the reaction were investigated, and it was found that the reaction proceeded quantitatively at pH 8.5, 70C in 5 min. The calibration graph is rectilinear over the range of 0.02-0.40 μg/mL. The relative standard deviation values for intraday and interday precision were 0.40-0.93 and 0.54-1.37%, respectively. The proposed method was applied to the assay of REB in tablets. Mean recovery of REB from the tablets ranged between 99.91-100.20%. The results were compared statistically with those obtained by a method reported in the literature. The method is sensitive, simple, and selective, and can be used for routine quality control analysis.
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Corina, Varsami. „An Analysis of Maritime Accidents Involving Oil Tankers from a Structural Point of View“. Scientific Bulletin of Naval Academy XIX, Nr. 1 (15.07.2018): 71–76. http://dx.doi.org/10.21279/1454-864x-18-i1-010.
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The international tanker owners pollution federation (ITOPF) is an international organization offering technical consultancy and information regarding pollution prevention and spillage prevention effect on the marine environment. ITOPF maintains a data base including oil spillages causes by oil tankers. It includes information regarding accidental spillage except those which result from acts of war. The data base includes information related to spillages starting from 1970. Our analysis intends to include the type of oil products spilled, the quantity, the cause and place of the incident as well as information related to the ships involved. For historical reasons, spillages are officially classified according to the quantities spilled: quantities lower than 7 t, between 7-700 t and over 700 t. According to the data registered until now, it was determined that out of almost 10.000 incidents, the great majority as in 81% of them are in the first category. Our paper intends to analyze information collected from public sources, such as media publications in the maritime transport field and different specialized publication as well as information given by owners and insurers.
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Abrahamsen, Niels, und Peter W. Readma. „Geomagnetic secular variation in Late Weichselian Allerød sediments from Nr. Lyngby (Denmark)“. Bulletin of the Geological Society of Denmark 44 (15.03.1997): 45–58. http://dx.doi.org/10.37570/bgsd-1998-44-03.
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Palaeomagnetic measurements on 400 specimens from lake sediments exposed in the cliff of the classic Late Glacial Allerød site at Nørre Lyngby in North Jutland, Denmark, are presented. Two profiles in the 7 m sequence of sand, silt and gyttja, spanning the time interval between c. 12 000 and c. 10 700 BP show about 5 cycles in the declination and about 2 cycles in inclination. Secular variation features as observed at this site are also recognizable at sites in southern Sweden and Soviet Karelia. Comparisons with Holocene records indicate that the short time-scale behaviour (i.e. < 103 y) of the geomagnetic field appears to have been similar since 14 000 BP, i.e. for a period considerably longer than the timescale of the variations themselves, thus suggesting that this type of behaviour is a permanent feature of the geomagnetic field. These secular variation features may be useful in local as well as more regional stratigraphical correlations for the Late Glacial and Holocene on a much more detailed timescale than is obtained from the magnetic reversal timescale used for older materials.
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Akivis, Maks A., und Vladislav V. Goldberg. „Dually Degenerate Varieties and the Generalization of a Theorem of Griffiths?Harris“. Acta Applicandae Mathematicae 86, Nr. 3 (Mai 2005): 249–65. http://dx.doi.org/10.1007/s10440-004-7029-7.
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Arieli, A., E. Naim, R. W. Benjamin und D. Pasternak. „The effect of feeding saltbush and sodium chloride on energy metabolism in sheep“. Animal Science 49, Nr. 3 (Dezember 1989): 451–57. http://dx.doi.org/10.1017/s0003356100032657.
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ABSTRACTThe effect of consumption of saltbush and sodium chloride on energy metabolism in sheep was investigated. Twenty-four Awassi wethers were fed at maintenance level and allotted to three treatments: saltbush (Atriplex barclayana), salt (NaCl) and control. Daily mineral intakes with these diets were 149, 158 and 57 g, respectively. The saltbush had been irrigated with an equal-part mixture of seawater and fresh water and contained 15 g nitrogen and 310 g ash per kg. Energy and nitrogen balance were conducted using indirect calorimetry. The disappearance of organic matter and nitrogen from saltbush in the rumen was studied by the polyester bag technique.Water intake of animals fed a high salt diet was 2·9 times higher and urine excretion was 3·7 times higher than in the control. Digested energy was proportionately 0·616 of dietary gross energy in the saltbush treatment, and 0·700 and 0·707 in the salt and control treatments respectively. Metabolizable energy (ME) was proportionately 0·795, 0·786 and 0·815 of digested energy, and heat production was 1·135, 1·043 and 0·867 of ME in the saltbush, salt and control treatments, respectively. The calculated values for digestible energy, ME, and net energy for maintenance on the saltbush diet were 5·02, 3·77 and 0·54 MJ/kg dry matter.It is suggested that the low energetic utilization of saltbush is related to its low digestibility and the associated increase in energy expenditure, which are apparently related to mineral metabolism in the rumen. To maintain sheep on saltbush diets efforts should be made to lower the mineral content of this shrub.
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Bataillou, Léa, Laure Martinelli, Clara Desgranges, Sophie Bosonnet, Kevin Ginestar, Frédéric Miserque, Yves Wouters et al. „Growth Kinetics and Characterization of Chromia Scales Formed on Ni–30Cr Alloy in Impure Argon at 700 °C“. Oxidation of Metals 93, Nr. 3-4 (19.02.2020): 329–53. http://dx.doi.org/10.1007/s11085-020-09958-7.
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Voltas, Núria, Victoria Arija, Estefania Aparicio und Josefa Canals. „Longitudinal study of psychopathological, anthropometric and sociodemographic factors related to the level of Mediterranean diet adherence in a community sample of Spanish adolescents“. Public Health Nutrition 19, Nr. 10 (28.01.2016): 1812–22. http://dx.doi.org/10.1017/s1368980015003560.
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AbstractObjectiveThe Mediterranean diet (MD) pattern has important health benefits; however, it seems that Spanish school-aged children have been abandoning this healthy pattern recently. We aimed to identify psychopathological, anthropometric and sociodemographic factors that may influence the risk of low MD adherence.DesignLongitudinal study in three phases. MD adherence was assessed using the Krece Plus food questionnaire and psychopathological symptoms using the Screen for Childhood Anxiety Related Emotional Disorders, Children’s Depression Inventory, Youth’s Inventory-4 and Eating Disorder Inventory-2. Anthropometric data were collected in the first and third phases.SettingsAll five representative areas in Reus, Spain.SubjectsAdolescents (n241).ResultsRegardless of past and current BMI, socio-economic status was a protective factor for low MD adherence (OR=0·805,P=0·003) and a risk factor for high BMI (OR=0·718,P=0·002; OR=0·707,P=0·001). Regardless of socio-economic status, depression was involved with risk of low adherence (OR=1·069,P=0·021). Girls with lower MD adherence presented significantly higher scores for eating disorders measured using the Eating Disorder Inventory-2 (low adherence, mean 18·9 (sd13·5); high adherence, mean 8·9 (sd9·0),P=0·020) and the Youth Inventory-4 (low adherence, mean 5·2 (sd4·3); medium adherence, mean 3·6 (sd3·2),P=0·044). They also presented higher depression symptoms (low adherence, mean 17·7 (sd9·6); medium adherence, mean 12·3 (sd7·2),P=0·01) than girls with high adherence.ConclusionsThe results highlight the influence of psychosocial factors on levels of MD adherence. These factors need to be taken into account when developing prevention and health promotion initiatives.
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Guinau, M., I. Vilajosana und J. M. Vilaplana. „GIS-based debris flow source and runout susceptibility assessment from DEM data – a case study in NW Nicaragua“. Natural Hazards and Earth System Sciences 7, Nr. 6 (26.11.2007): 703–16. http://dx.doi.org/10.5194/nhess-7-703-2007.
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Abstract. In October 1998, Hurricane Mitch triggered numerous landslides (mainly debris flows) in Honduras and Nicaragua, resulting in a high death toll and in considerable damage to property. The potential application of relatively simple and affordable spatial prediction models for landslide hazard mapping in developing countries was studied. Our attention was focused on a region in NW Nicaragua, one of the most severely hit places during the Mitch event. A landslide map was obtained at 1:10 000 scale in a Geographic Information System (GIS) environment from the interpretation of aerial photographs and detailed field work. In this map the terrain failure zones were distinguished from the areas within the reach of the mobilized materials. A Digital Elevation Model (DEM) with 20 m×20 m of pixel size was also employed in the study area. A comparative analysis of the terrain failures caused by Hurricane Mitch and a selection of 4 terrain factors extracted from the DEM which, contributed to the terrain instability, was carried out. Land propensity to failure was determined with the aid of a bivariate analysis and GIS tools in a terrain failure susceptibility map. In order to estimate the areas that could be affected by the path or deposition of the mobilized materials, we considered the fact that under intense rainfall events debris flows tend to travel long distances following the maximum slope and merging with the drainage network. Using the TauDEM extension for ArcGIS software we generated automatically flow lines following the maximum slope in the DEM starting from the areas prone to failure in the terrain failure susceptibility map. The areas crossed by the flow lines from each terrain failure susceptibility class correspond to the runout susceptibility classes represented in a runout susceptibility map. The study of terrain failure and runout susceptibility enabled us to obtain a spatial prediction for landslides, which could contribute to landslide risk mitigation.
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Quintero, A., M. Libera, C. Cabral, C. Lavoie und J. M. E. Harper. „Mechanisms for enhanced C54–TiSi2 formation in Ti–Ta alloy films on single-crystal Si“. Journal of Materials Research 14, Nr. 12 (Dezember 1999): 4690–700. http://dx.doi.org/10.1557/jmr.1999.0635.
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The mechanisms are studied for enhanced formation of C54–TiSi2 at about 700 °C when rapid thermal annealing at 3 °C/s in N2 is performed on 32-nm-thick codeposited Ti–5.9 at.% Ta on Si(100) single-crystal substrates. The enhancement is related to an increased C54–TiSi2 nucleation rate due to the development of a multilayered microstructure. The multilayer microstructure forms at temperatures below 600 °C with the formation of an amorphous disilicide adjacent to the Si substrate and a M5Si3 (M = Ti, Ta) capping layer. This amorphous disilicide crystallizes at higher temperatures to C49–TiSi2. The multilayer microstructure introduces an additional interface that increases the area available for the heterogeneous nucleation of C54. The capping layer is identified as hexagonal Ti 5Si3 or its isomorphous compound (Ti1–xTax)5Si3. Crystal simulations demonstrate that C54(040) has a lattice mismatch of 6–7% relative to Ti5Si3(300) suggesting that a pseudomorphic epitaxial relationship may lower the interfacial energy between these two phases and reduce the energy barrier for C54 nucleation. A C40 disilicide phase was also observed at temperatures above that required to form C54–TiSi2 suggesting that, in the present experiments, the C40 phase does not play a major role in catalyzing C54 formation.
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Magnus, Dan, Santosh Bhatta und Julie Mytton. „432 Establishing injury surveillance in emergency departments in Nepal: epidemiology and burden of paediatric injuries“. Emergency Medicine Journal 37, Nr. 12 (23.11.2020): 825.2–827. http://dx.doi.org/10.1136/emj-2020-rcemabstracts.7.
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Aims/Objectives/BackgroundGlobally, injuries cause more than 5 million deaths annually. Children and young people are a particularly vulnerable group and injuries are the leading cause of death in people aged 5–24 years globally and a leading cause of disability.In most low and middle-income countries where the majority of global child injury burden occurs, systems for routinely collecting injury data are limited. There is a continuing need for better data on childhood injuries and for injury surveillance.The aim of our study was to introduce a hospital-based injury surveillance tool – the first of its kind in Nepal and explore its feasibility. We undertook prospective collection of data on all injuries/trauma presenting to 2 hospital emergency departments to describe the epidemiology of paediatric hospital injury presentations and associated risk factors.Methods/DesignA new injury surveillance system for use in emergency departments in Nepal was designed and used to collect data on patients presenting with injuries. Data were collected prospectively in two hospitals 24 h a day over 12 months (April 2019 - March 2020) by trained data collectors using tablet computers.Abstract 432 Table 1Socio-demographic profile and characteristics of injury among children attending emergency of hospitals in Makwanpur district, Nepal, April 2019 – March 2020 (N=2696)CharacteristicsFrequencyGender Male 1778 Female 918 Age groups 0–4 years 653 5–9 years 866 10–14 years 680 15–17 years 497 Median year (IRQ) 8 (5 – 13) Ethnicity/caste Janajati 1384 Brahmin/Chhetri 892 Dalit 148 Madhesi 146 Muslim 74 Others 50 Unknown 2 Place where injury occurred Home/Compound 1576 Highway/road/street 636 School 233 Recreational area 138 Workplace 76 Other 37 Activities at the time injury occurred Leisure/Play 1889 Travelling (other than to/from school/work) 296 Work 202 Travelling (to/from school/work) 184 Education 42 Organised sports 11 Other 52 Unknown 20 Intent of injury Unintentional 2560 Intentional (self-harm) 61 Intentional (assault) 75 Unintentional (n=2560) Fall 912 Animal or insect related 728 Road traffic injury 356 Injured by a blunt force 201 Stabbed, cut or pierced 176 Fire, burn or scald 65 Poisoning 52 Suffocation/choking 36 Electrocution 12 Drowning and submersion 7 Other 13 Unknown 2 Self-harm (n=61) Poisoning 38 Hanging, strangulation, suffocation 12 Stabbed, cut or pierced 6 Injured by blunt object 4 Other 1 Assault (n=75) Bodily force (physical violence) 43 Injured by blunt object 18 Stabbed, cut or pierced 8 Pushing from a high place 2 Poisoning 2 Sexual assault 1 Other 1 Nature of injury (one most severe) Cuts, bites or open wound 1378 Bruise or superficial injury 383 Fracture 299 Sprain, strain or dislocation 243 Internal injury 124 Head Injury/Concussion 83 Burns 67 Other 115 Unknown 2 Not recorded 2 Severity of injury No apparent injury 125 Minor 1645 Moderate 813 Severe 111 Not recorded 2 Disposition Discharged 2317 Admitted to hospital 164 Transferred to another hospital 179 Died 21 Leave Against Medical Advice (LAMA) 11 Unknown 2 Not recorded 2 Note:Not recorded = missing cases95% CI calculated using one proportion test and normal approximation method in Minitab.Abstract 432 Table 2Distribution of injuries by age-group, sex and mechanism of injury among children attending emergency of hospitals in Makwanpur district, Nepal, April 2019 – March 2020Age groups & Sex0 - 4 years5 - 9 years10–14 years15–17 yearsMaleFemaleTotalIntent & mechanismsn (%)n (%)n (%)n (%)n (%)n (%)n (%)Unintentional Fall 239 (26.2) 328 (36.0) 249 (27.3) 96 (10.5) 636 (69.7) 276 (30.3) 912 (100) Animal or insect related 175 (24.0) 260 (35.7) 190 (26.1) 103 (14.1) 470 (64.6) 258 (35.4) 728 (100) Road traffic injury 49 (13.8) 108 (30.3) 86 (24.2) 113 (31.7) 223 (62.6) 133 (37.4) 356 (100) Injured by a blunt force 54 (26.9) 74 (36.8) 49 (24.4) 24 (11.9) 150 (74.6) 51 (25.4) 201 (100) Stabbed, cut or pierced 20 (11.4) 56 (31.8) 49 (27.8) 51 (29.0) 127 (72.2) 49 (27.8) 176 (100) Fire, burn or scald 42 (64.6) 10 (15.4) 9 (13.8) 4 (6.2) 27 (41.5) 38 (58.5) 65 (100) Poisoning 33 (63.5) 6 (11.5) 5 (9.6) 8 (15.4) 26 (50.0) 26 (50.0) 52 (100) Suffocation/choking 24 (66.7) 5 (13.9) 2 (5.6) 5 (13.9) 20 (55.6) 16 (44.4) 36 (100) Electrocution 2 (15.7) 0 (0.0) 3 (25.0) 7 (58.3) 10 (83.3) 2 (16.7) 12 (100) Drowning and submersion 1 (14.3) 1 (14.3) 3 (42.9) 2 (28.6) 3 (42.9) 4 (57.1) 7 (100) Other 6 (46.2) 4 (30.8) 3 (23.1) 0 (0.0) 10 (76.9) 3 (23.1) 13 (100) Unknown 2 (100) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 2 (100) 2 (100) Total 647 (25.3) 852 (33.3) 648 (25.3) 413 (16.1) 1702 (66.5) 858 (33.5) 2560 (100) Self-harm Poisoning 0 (0.0) 0 (0.0) 6 (15.8) 32 (84.2) 7 (18.4) 31 (81.6) 38 (100) Hanging 0 (0.0) 0 (0.0) 3 (25.0) 9 (75.0) 4 (33.3) 8 (66.7) 12 (100) Stabbed, cut or pierced 0 (0.0) 0 (0.0) 2 (33.3) 4 (66.7) 1 (16.7) 5 (83.3) 6 (100) Injured by blunt object 0 (0.0) 2 (50.0) 2 (50.0) 0 (0.0) 4 (100) 0 (0.0) 4 (100) Other 0 (0.0) 0 (0.0) 0 (0.0) 1 (100) 1 (100) 0 (0.0) 1 (100) Total 0 (0.0) 2 (3.3) 13 (21.3) 46 (75.4) 17 (27.9) 44 (72.1) 61 (100) Assault Bodily force (physical violence) 3 (7.0) 1 (2.3) 11 (25.6) 28 (65.1) 37 (86.0) 6 (14.0) 43 (100) Injured by blunt object 2 (11.1) 8 (44.4) 4 (22.2) 4 (22.2) 13 (72.2) 5 (27.8) 18 (100) Stabbed, cut or pierced 1 (12.5) 0 (0.0) 2 (25.0) 5 (62.5) 7 (87.5) 1 (12.5) 8 (100) Pushing from a high place 0 (0.0) 1 (50.0) 1 (50.0) 0 (0.0) 1 (50.0) 1 (50.0) 2 (100) Poisoning 0 (0.0) 1 (50.0) 0 (0.0) 1 (50.0) 1 (50.0) 1 (50.0) 2 (100) Sexual assault 0 (0.0) 0 (0.0) 1 (100) 0 (0.0) 0 (0.0) 1 (100) 1 (100) Other 0 (0.0) 1 (100) 0 (0.0) 0 (0.0) 0 (0.0) 1 (100) 1 (100) Total 6 (8.0) 12 (16.0) 19 (25.3) 38 (50.7) 59 (78.7) 16 (21.3) 75 (100) Abstract 432 Table 3Association of injury location, nature and severity with age among children attending emergency of hospitals in Makwanpur district, Nepal, April 2019 – March 2020Age groups0 – 4 years5 – 9 years10–14 years15–17 yearsTotalChi-SquareInjury characteristicsn (%)n (%)n (%)n (%)n (%)P valueLocation of injury sustained Home/Compound 537 (34.1) 504 (32.0) 319 (20.2) 216 (13.7) 1576 (100) <0.001 Highway/road/street 85 (13.4) 196 (30.8) 190 (29.9) 165 (25.9) 636 (100) School 15 (6.4) 107 (45.9) 85 (36.5) 26 (11.2) 233 (100) Recreational area 9 (6.5) 44 (31.9) 55 (39.9) 30 (21.7) 138 (100) Workplace 1 (1.3) 4 (5.3) 19 (25.0) 52 (68.4) 76 (100) Other 6 (16.2) 11 (29.7) 12 (32.4) 8 (21.6) 37 (100) Total 653 (24.2) 866 (32.1) 680 (25.2) 497 (18.4) 2696 (100) Nature of injury Cuts, bites or open wound 328 (23.8) 506 (36.7) 314 (22.8) 230 (16.7) 1378 (100) <0.001 Bruise or superficial injury 81 (21.1) 99 (25.8) 118 (30.8) 85 (22.2) 383 (100) Fracture 48 (16.1) 101 (33.8) 112 (37.5) 38 (12.7) 299 (100) Sprain, strain or dislocation 48 (19.8) 78 (32.1) 72 (29.6) 45 (18.5) 243 (100) Internal injury 44 (35.5) 8 (6.5) 18 (14.5) 54 (43.5) 124 (100) Head Injury/Concussion 18 (21.7) 26 (31.3) 18 (21.7) 21 (25.3) 83 (100) Burns 42 (62.7) 9 (13.4) 10 (14.9) 6 (9.0) 67 (100) Other 41 (35.7) 38 (33.0) 18 (15.7) 18 (15.7) 115 (100) Unknown 2 (100) 0 (0.0) 0 (0.0) 0 (0.0) 2 (100) Total 652 (24.2) 865 (32.1) 680 (25.2) 497 (18.4) 2694 (100) Severity of injury No apparent injury 39 (31.2) 45 (36.0) 26 (20.8) 15 (12.0) 125 (100) <0.001 Minor 419 (25.5) 535 (32.5) 406 (24.7) 285 (17.3) 1645 (100) Moderate 171 (21.0) 262 (32.2) 225 (27.7) 155 (19.1) 813 (100) Severe 23 (20.7) 23 (20.7) 23 (20.7) 42 (37.8) 111 (100) Total 652 (24.2) 865 (32.1) 680 (25.2) 497 (18.4) 2694 (100) Abstract 432 Table 4Association of injury location, nature and severity with sex among children attending emergency of hospitals in Makwanpur district, Nepal, April 2019 – March 2020SexMaleFemaleTotalChi-SquareInjury characteristicsn (%)n (%)n (%)P valueLocation of injury sustained Home/Compound 979 (62.1) 597 (37.9) 1576 (100) <0.001 Highway/road/street 421 (66.2) 215 (33.8) 636 (100) School 176 (75.5) 57 (24.5) 233 (100) Recreational area 111 (80.4) 27 (19.6) 138 (100) Workplace 62 (81.6) 14 (18.4) 76 (100) Other 29 (78.4) 8 (21.6) 37 (100) Total 1778 (65.9) 918 (34.1) 2696 (100) Nature of injury Cuts, bites or open wound 959 (69.6) 419 (30.4) 1378 (100) <0.001 Bruise or superficial injury 246 (64.2) 137 (35.8) 383 (100) Fracture 200 (66.9) 99 (33.1) 299 (100) Sprain, strain or dislocation 154 (63.4) 89 (36.6) 243 (100) Internal injury 50 (40.3) 74 (59.7) 124 (100) Head Injury/Concussion 59 (71.1) 24 (28.9) 83 (100) Burns 27 (40.3) 40 (59.7) 67 (100) Other 79 (68.7) 36 (31.3) 115 (100) Unknown 2 (100) 0 (0.0) 2 (100) Total 1776 (65.9) 918 (34.1) 2694 (100) Severity of injury No apparent injury 81 (64.8) 44 (35.2) 125 (100) 0.048 Minor 1102 (67.0) 543 (33.0) 1645 (100) Moderate 533 (65.6) 280 (34.4) 813 (100) Severe 60 (54.1) 51 (45.9) 111 (100) Total 1776 (65.9) 918 (34.1) 2694 (100) Abstract 432 Table 5Distribution of injuries by outcome and mechanism of injury among children attending emergency of hospitals in Makwanpur district, Nepal, April 2019 – March 2020Outcome of injuryDischargedAdmittedTransferredDiedLAMAUnknownTotalIntent & mechanismsn (%)n (%)n (%)n (%)n (%)n (%)n (%)Unintentional Fall 787 (86.5) 65 (7.1) 53 (5.8) 0 (0.0) 4 (0.4) 1 (0.1) 910 (100) Animal/insect bite/sting 704 (96.7) 3 (0.4) 19 (2.6) 0 (0.0) 1 (0.1) 1 (0.1) 728 (100) Road traffic injury 260 (73.0) 47 (13.2) 44 (12.4) 5 (1.4) 0 (0.0) 0 (0.0) 356 (100) Injured by a blunt force 190 (94.5) 4 (2.0) 6 (3.0) 0 (0.0) 1 (0.5) 0 (0.0) 201 (100) Stabbed, cut or pierced 165 (93.8) 8 (4.5) 3 (1.7) 0 (0.0) 0 (0.0) 0 (0.0) 176 (100) Fire, burn or scald 52 (80.0) 12 (18.5) 1 (1.5) 0 (0.0) 0 (0.0) 0 (0.0) 65 (100) Poisoning 30 (57.7) 4 (7.7) 16 (30.8) 1 (1.9) 1 (1.9) 0 (0.0) 52 (100) Suffocation/choking/asphyxia 24 (66.7) 4 (11.1) 6 (16.7) 1 (2.8) 1 (2.8) 0 (0.0) 36 (100) Electrocution 7 (58.3) 2 (16.7) 2 (16.7) 1 (8.3) 0 (0.0) 0 (0.0) 12 (100) Drowning and submersion 4 (57.1) 0 (0.0) 0 (0.0) 3 (42.9) 0 (0.0) 0 (0.0) 7 (100) Other 12 (92.3) 1 (7.7) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 13 (100) Unknown 2 (100) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 2 (100) Total 2237 (87.5) 150 (5.9) 150 (5.9) 11 (0.4) 8 (0.3) 2 (0.1) 2558 (100) Self-harm Poisoning 5 (13.2) 8 (21.1) 23 (60.5) 0 (0.0) 2 (5.3) 0 (0.0) 38 (100) Hanging 1 (8.3) 0 (0.0) 1 (8.3) 10 (83.3) 0 (0.0) 0 (0.0) 12 (100) Stabbed, cut or pierced 6 (100) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 6 (100) Injured by blunt object 4 (100) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 4 (100) Other 1 (100) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (100) Total 17 (27.9) 8 (13.1) 24 (39.3) 10 (16.4) 2 (3.3) 0 (0.0) 61 (100) Assault Bodily force (physical violence) 34 (79.1) 5 (11.6) 3 (7.0) 0 (0.0) 1 (2.3) 0 (0.0) 43 (100) Injured by blunt object 18 (100) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 18 (100) Stabbed, cut or pierced 6 (75.0) 1 (12.5) 1 (12.5) 0 (0.0) 0 (0.0) 0 (0.0) 8 (100) Pushing from a high place 2 (100) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 2 (100) Poisoning 1 (50) 0 (0.0) 1 (50.0) 0 (0.0) 0 (0.0) 0 (0.0) 2 (100) Sexual assault 1 (100) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (100) Other 1 (100) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (100) Total 63 (84.0) 6 (8.0) 5 (6.7) 0 (0.0) 1 (1.3) 0 (0.0) 75 (100) Abstract 432 Figure 1Seasonal variation of injuries identified by the injury surveillance system over a year among children attending emergency of hospitals in Makwanpur district, Nepal, April 2019 – March 2020Results/ConclusionsThe total number of ED patients with injury in the study was 10,154.2,696 were patients aged <18 years. Most injuries in children were unintentional and over half of children presenting with injuries were <10 years of age. Falls, animal bites/stings and road traffic injuries accounted for nearly 75% of all injuries with some (drowning, poisonings and burns) under-represented. Over half of injuries were cuts, bites and open wounds. The next most common injury types were superficial injuries (14.2%); fractures (11.1%); sprains/dislocations (9.0%). Child mortality was 1%.This is the biggest prospective injury surveillance study in a low or middle country in recent years and supports the use of injury surveillance in Nepal for reducing child morbidity and mortality through improved data.CHILD PAPER: RESULTS SECTIONTotal number of ED patients: 33046Total number of ED patient with injury: 10154 (adult=7458 & children=2696)8.2% (n=2696) patients with injury were children aged <18 yearsHetauda hospital: 2274 (84.3%)Chure hill hospital: 422 (15.7%)
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Czernecka-Rej, Bożena. „Can Başkent, Thomas Macaulay Ferguson (eds.), Graham Priest on Dialetheism and Paraconsistency, Springer International Publishing, Outstanding Contributions to Logic, Vol. 18, 2019, pp. 704+xi; ISBN 978-3-030-25367-7 (Softcover) 106.99 €, ISBN 978-3-030-25364-6 (Hardcover) 149.79 €.“ Studia Logica 110, Nr. 2 (14.02.2022): 593–96. http://dx.doi.org/10.1007/s11225-021-09980-z.
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Ozcan, Muhit, Seung Tae Lee, Felix Mensah, Dipenkumar Modi, Alexander Fossa, Won Seog Kim, Ewa Paszkiewicz-Kozik et al. „Zilovertamab vedotin (MK 2140) in relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL): Early results from the phase 2 waveLINE-004 study.“ Journal of Clinical Oncology 41, Nr. 16_suppl (01.06.2023): 7531. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.7531.
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7531 Background: Treatment options are limited for patients (pts) with R/R DLBCL who are not candidates for autologous stem cell transplant (ASCT). ROR1 is an oncofetal protein pathologically expressed in hematologic malignancies including DLBCL. In the phase 1 first-in-human study in hematologic malignancies (waveLINE-001), the ROR1-targeting antibody-drug conjugate zilovertamab vedotin (ZV) showed promising activity and manageable safety in R/R DLBCL. The single-arm, open-label, phase 2 waveLINE-004 study (NCT05144841) is designed to evaluate activity of ZV monotherapy in pts with R/R DLBCL. Early data are reported. Methods: Eligible pts were ≥18 y old, had histologically confirmed DLBCL by WHO classification, measurable disease per Lugano 2014 criteria, PET-positive disease, and ECOG PS of 0-2. Pts must have received ≥2 prior lines of therapy (including an alkylating agent, anthracycline, and an anti-CD20 antibody) with progression after or ineligibility for ASCT and CAR T-cell therapy. All pts received ZV 2.5 mg/kg IV Q3W until disease progression, unacceptable toxicity, or withdrawal. Primary end point was ORR per Lugano 2014 criteria. Safety and tolerability was a secondary end point. Safety was evaluated in all pts who received ≥1 dose of treatment; efficacy was reported for pts with ≥3 mo follow-up. Results: At data cutoff (Nov 16, 2022), 40 pts enrolled and received ≥1 dose of treatment; 23 (58%) had discontinued and 17 (43%) were ongoing. Median age was 68.0 y, 29 (73%) pts were male, 37 (93%) had an ECOG PS of 0 or 1, 24 (60%) had ≥3 prior lines of therapy, and 10 (25%) received prior ASCT. 11 (28%) pts received prior CAR-T. Median follow-up (range) was 2.6 mo (0.3-7.9) for all pts and 6.0 mo (3.0-7.9) for pts in the efficacy analysis (n = 20). ORR by investigator review was 30% (95% CI, 11.9-54.3), with 2 pts having a CR and 4 a PR; 5 pts had SD (DCR, 55% [95% CI, 31.5-76.9]). Treatment related AEs (TRAEs) occurred in 28 (70%) pts, most commonly (≥15%) diarrhea (9 [23%]), anemia (8 [20%]), neutropenia (7 [18%]), neutrophil count decreased (7 [18%]), and alopecia (6 [15%]). Grade 3/4 TRAEs occurred in 16 (40%) pts, most commonly (≥10%) neutropenia (7 [18%]), anemia (6 [15%]), and neutrophil count decreased (4 [10%]). Discontinuation due to a TRAE of diabetic ketoacidosis occurred in 1 (3%) pt. Grade 1/2 treatment-related peripheral neuropathy occurred in 6 (15%) pts; no grade 3/4 AEs occurred. Dose reduction due to treatment-related peripheral neuropathy occurred in 3 (8%) pts. No infusion reaction or tumor lysis syndrome due to treatment occurred and no pts died because of TRAEs. Conclusions: Early results show that ZV had clinically meaningful antitumor activity in pts with R/R DLBCL who progressed after or have been ineligible for ASCT and/or CAR-T. Additionally, the safety profile was manageable and consistent with other monomethyl auristatin E–containing agents. Clinical trial information: NCT05144841 .
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Lipp, Christian, und Thomas Schleid. „Die Selten-Erd-Metall(III)-Fluorid-Oxoselenate(IV) MF[SeO3] (M = Y, Ho–Lu) imYF[SeO3]-Typ/ The Rare-Earth Metal(III) Fluoride Oxoselenates(IV) MF[SeO3] (M = Y, Ho–Lu) with YF[SeO3]-type Structure“. Zeitschrift für Naturforschung B 64, Nr. 4 (01.04.2009): 375–82. http://dx.doi.org/10.1515/znb-2009-0403.
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YF[SeO3]-type rare-earth metal(III) fluoride oxoselenates(IV) MF[SeO3] (M = Y, Ho-Lu) crystallize monoclinically in space group P21/c (no. 14) with Z = 4. Obeying the lanthanoid contraction, the lattice parameters decrease successively from a = 657.65(7), b = 689.71(7), c = 717.28(7) pm and β = 99.036(5)° for YF[SeO3] at 298 K to a = 648.39(6), b = 681.28(7), c = 705.81(7) pm and β = 98.657(5)° for LuF[SeO3] at 100 K (LT-LuF[SeO3], LT ≡ Low Temperature). The M3+ cations are occupying the general site 4e. Contrary to the triclinic structure of RT-LuF[SeO3] (RT ≡ Room Temperature; CN(Lu3+) = 7) the higher coordination number eight is achieved for the M3+ cations in all YF[SeO3]-type compounds. This results in [MO6F2]11− polyhedra (d(M-O) = 228 - 243/225 - 239 plus 263/258 pm, d(M-F) = 219/216 pm, M = Y/Lu), which are connected via common O・ ・ ・O edges to form infinite chains 1∞{[MOe 4/2Ot 2/1Ft 2/1]7−} (e ≡ edge-sharing, t ≡ terminal) running along [010]. Neighboring chains share common O3・ ・ ・O3 and O3・ ・ ・F edges generating 2∞{[M(O3)3/3(O2)2/2(O1)1/1F2/2]4−} sheets parallel to the (100) plane. Finally, these 2 ∞{[MO3F]4−} sheets are interconnected by Se4+ cations, which appear in isolated ψ1-tetrahedral [SeO3]2− anions (d(Se-O) = 167 - 175 pm). For the synthesis of the YF[SeO3]-type rare-earth metal(III) fluoride oxoselenates( IV) MF[SeO3] (M = Y, Ho-Lu), the rare-earth metal sesquioxides (M2O3) and trifluorides (MF3), and selenium dioxide (SeO2) in molar ratios of 1 : 1 : 3 with the fluxing agent CsBr were reacted within five days at 700 - 750 °C in evacuated graphitized silica ampoules.
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Henke, Peter. „Incidence and Risk Factors of Peripheral Arterial Occlusive Disease in a Prospective Cohort of 700 Adult Men Followed for 5 Years“. World Journal of Surgery 34, Nr. 8 (29.05.2010): 1980–81. http://dx.doi.org/10.1007/s00268-010-0629-7.
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Ortiz, Johana, John Van Camp, Sylviana Wijaya, Silvana Donoso und Lieven Huybregts. „Determinants of child malnutrition in rural and urban Ecuadorian highlands“. Public Health Nutrition 17, Nr. 9 (30.09.2013): 2122–30. http://dx.doi.org/10.1017/s1368980013002528.
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AbstractObjectiveTo identify and compare the sociodemographic determinants of stunting, wasting and overweight among infants of urban and rural areas in the Ecuadorian highlands.DesignCross-sectional study.SettingNabon (rural) and Cuenca (urban) cantons, Azuay Province, Ecuador.SubjectsA total of 703 children aged 0–24 months and their caregivers (227 rural and 476 urban) recruited during the period from June to September 2008.ResultsStunting prevalence was significantly higher in the rural area (37·4 %v. 17·7 %;P< 0·001) while wasting (7·1 %) and overweight (17·1 %) prevalence were more similar between areas. Determinants of stunting for the pooled sample were male gender (OR = 1·43; 95 % CI 1·06, 1·92;P= 0·02), preterm delivery (OR = 1·65; 95 % CI 1·14, 2·38;P= 0·008), child's age (OR = 1·04; 95 % CI 1·01, 1·07;P= 0·011), maternal education (OR = 0·95; 95 % CI 0·92, 0·99;P= 0·025) and facility-based delivery (OR = 0·57; 95 % CI 0·45, 0·74;P< 0·001). The latter was also a determinant of overweight (OR = 0·39; 95 % CI 0·25, 0·62;P< 0·001). Rural determinants of stunting were maternal height (OR = 0·004; 95 % CI 0·00004, 0·39;P= 0·018), diarrhoea prevalence (OR = 2·18; 95 % CI 1·13, 4·21;P= 0·02), socio-economic status (OR = 0·79; 95 % CI 0·64, 0·98;P= 0·030) and child's age (OR = 1·07; 95 % CI 1·02, 1·11;P= 0·005). Urban determinants were: maternal BMI for stunting (OR = 0·91; 95 % CI 0·84, 0·99;P= 0·027), cough prevalence (OR = 0·57; 95 % CI 0·34, 0·96;P= 0·036) and facility-based delivery (OR = 0·25; 95 % CI 0·09, 0·73;P= 0·011) for overweight, and hygiene for wasting (OR = 0·57; 95 % CI 0·36, 0·89;P= 0·013).ConclusionsInfant malnutrition was associated with different sociodemographic determinants between urban and rural areas in the Ecuadorian highlands, a finding which contributes to prioritize the determinants to be assessed in nutritional interventions.
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Nyoni, Bothwell, Sifundo Duma, Lukanyo Bolo, Shaka Shabangu und Shanganyane P. Hlangothi. „Co-pyrolysis of South African bituminous coal and Scenedesmus microalgae: Kinetics and synergistic effects study“. International Journal of Coal Science & Technology 7, Nr. 4 (21.03.2020): 807–15. http://dx.doi.org/10.1007/s40789-020-00310-7.
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AbstractIn this work, the co-pyrolysis of coal and algae is explored with special emphasis on decomposition kinetics and the possibility of the existence of synergistic effects. Modelling and kinetics analysis based approaches were used for the investigation of the existence of synergistic effects. The co-pyrolysis kinetics was studied using the model-free, Coats–Redfern integral method. The kinetics were evaluated for 1st and 2nd order reaction models. Results reveal that Scenedesmus microalgae is characterised by a two stage decomposition process that occurs at temperature ranges of 200–400 °C and 500–700 °C with activation energy of 145.5 and 127.3 kJ/mol, respectively. Bituminous coal has a two stage, slow decomposition process that occurs at temperature ranges of 400–700 °C and above 750 °C with an activation energy of 81.8 and 649.3 kJ/mol, respectively. Furthermore, co-pyrolysis of coal and microalgae is characterised by three stages whose kinetics are dominated by the pyrolysis of the individual materials. For the studied range of coal/algae ratios, the three pyrolysis stages occur in the approximate temperature ranges of 200–400 °C, 430–650 °C and above 750 °C, with activation energies in the ranges of 131–138, 72–78 and 864.5–1235 kJ/mol, respectively. Modelling and kinetics study showed that there is strong evidence of interactions between coal and microalgae that manifest as synergistic effects especially in the second and third stages of decomposition.
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Bruce, Michael I., Brian W. Skelton, Natasha N. Zaitseva und Allan H. White. „Temperature Dependence of the Crystal Structure of Ru4(µ4-C2H2)(CO)9(η-PhMe)“. Australian Journal of Chemistry 52, Nr. 7 (1999): 681. http://dx.doi.org/10.1071/ch99035.
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The thermal reaction between Ru4(µ4-C2H2)(CO)12 and toluene afforded Ru4(µ4-C2H2)(CO)9(η-PhMe), whose crystal and molecular structures, determined at c. 300 and 153 K, are reported [triclinic, P 1; a ≈ 8 . 0; b ≈ 10 . 4; c ≈ 13 . 7 Å, a ≈ 87; b ≈ 89 . 7; γ ≈ 70°, Z = 2; conventional R values on |F| at convergence were 0 . 027 (300 K), 0 . 020 (153 K) for 4561, 4761 independent ‘observed’ [F >4σ(F)] reflections, respectively]. At low temperature, the structure is a nicely ordered Ru4 butterfly with a C2H2 ligand sitting between the wing tips and an η6 -PhMe ligand attached to one of the wing-tip atoms along the extension of the axis between them. At 300 K, a disordered component is evident, 9% occupancy of the wing-tip atom appended to toluene being displaced by 0 . 701(8) Å so that the bonding to the toluene approaches η2; this is accompanied by a counterpart displacement of one of the hinge Ru atoms. It is suggested that this is the first stage of a putative migration of the arene from wing-tip to hinge Ru atoms.