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1
Sobański, Remigiusz. „Teoria prawa kościelnego“. Prawo Kanoniczne 31, Nr. 1-2 (05.06.1988): 3–12. http://dx.doi.org/10.21697/pk.1988.31.1-2.01.
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Elaboratio theariae iuris ecclesialis postulatur. Distingui debet theoria eventus iuridici qua phaenomena iuridica enueleantur et theoria iuris utpote scientia iuridica. Theoria iuris ecclesialis de qua agitur in ambitu theologiae uiti pars scienitiae iuris canonici comprehendiitur. Breviter protolemata praecipua theoriae iuris ecclesialis demonstrantur. Versio germanica articuli in ZfevKR (32, 1987, 535—545, Festschrift Dombois) invenitur.
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Robson, Joanna, Helen Doll, Ravi Suppiah, Oliver Flossmann, Lorraine Harper, Peter Höglund, David Jayne, Alfred Mahr, Kerstin Westman und Raashid Luqmani. „Damage in the anca-associated vasculitides: long-term data from the European Vasculitis Study group (EUVAS) therapeutic trials“. Annals of the Rheumatic Diseases 74, Nr. 1 (15.11.2013): 177–84. http://dx.doi.org/10.1136/annrheumdis-2013-203927.
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ObjectivesTo describe short-term (up to 12 months) and long-term (up to 7 years) damage in patients with newly diagnosed antineutrophil-cytoplasm antibody-associated vasculitis (AAV).MethodsData were combined from six European Vasculitis Study group trials (n=735). Long-term follow-up (LTFU) data available for patients from four trials (n=535). Damage accrued was quantified by the Vasculitis Damage Index (VDI). Sixteen damage items were defined a priori as being potentially treatment-related.ResultsVDI data were available for 629 of 735 patients (85.6%) at baseline, at which time 217/629 (34.5%) had ≥1 item of damage and 32 (5.1%) ≥5 items, reflecting disease manifestations prior to diagnosis and trial enrolment. LTFU data were available for 467/535 (87.3%) at a mean of 7.3 years postdiagnosis. 302/535 patients (56.4%) had VDI data at LTFU, with 104/302 (34.4%) having ≥5 items and only 24 (7.9%) no items of damage. At 6 months and LTFU, the most frequent items were proteinuria, impaired glomerular filtration rate, hypertension, nasal crusting, hearing loss and peripheral neuropathy. The frequency of damage, including potentially treatment-related damage, rose over time (p<0.01). At LTFU, the most commonly reported items of treatment-related damage were hypertension (41.5%; 95% CI 35.6 to 47.4%), osteoporosis (14.1%; 9.9 to 18.2%), malignancy (12.6%; 8.6 to 16.6%), and diabetes (10.4%; 6.7 to 14.0%).ConclusionsIn AAV, renal, otolaryngological and treatment-related (cardiovascular, disease, diabetes, osteoporosis and malignancy) damage increases over time, with around one-third of patients having ≥5 items of damage at a mean of 7 years postdiagnosis.
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Liao, Guang Ming, Chun Hong Zheng und Shou Zhi Pu. „Research on Photochromic Materials with Synthesis and Properties of 1-(2-Methyl-3-Benzothiophene)-2-[2-Methyl-5-(3-Cyanophenyl)-3-Thienyl]Perfluorocyclopentene“. Applied Mechanics and Materials 662 (Oktober 2014): 95–98. http://dx.doi.org/10.4028/www.scientific.net/amm.662.95.
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An asymmetrical photochromic diarylethene1-(2-Methyl-3-benzothiophene)-2-[2-methyl-5-(3-cyanophenyl)-3-thienyl] perfluorocyclopentene (1o) was synthesized and its phtochromic, fluorescent properties in both solution and PMMA films were investigated in detail. This compound exhibited remarkable photochromism, upon irradiation with 297 nm UV light, the colorless solution of 1o turned to violet with a new visible absorption band centered at 535 nm (ε = 1.08 × 104 L mol-1 cm-1) attributable to the closed-ring isomer 1c. The emission intensity of diarylethene 1o in a photostationary state was quenched to ca. 32% in hexane and 43% in PMMA film.
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CRAIK, W. A. „Reviews“. Notes and Queries 32, Nr. 4 (01.12.1985): 535–36. http://dx.doi.org/10.1093/nq/32-4-535.
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Min, Young-Kee, Sora Baek, Eun Kyoung Kang und Seung-Joo Nam. „Characteristics of Patients With Esophageal Dysphagia Assessed by Chest X-Ray Imaging After Videofluoroscopic Swallowing Study“. Annals of Rehabilitation Medicine 44, Nr. 1 (29.02.2020): 38–47. http://dx.doi.org/10.5535/arm.2020.44.1.38.
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Objective To evaluate the prevalence rate, types, characteristics, and associated factors of esophageal dysphagia detected on chest X-ray images after videofluoroscopic swallowing study (VFSS).Methods The medical records of 535 adults were reviewed retrospectively. Chest X-ray images taken after barium swallow study were analyzed and presence of any residual barium in the esophagus was considered as esophageal dysphagia. Esophageal dysphagia was classified based on the largest width of barium deposit (mild, <2 cm; severe ≥2 cm) and the anatomic level at which it was located (upper and lower esophagus).Results Esophageal residual barium on chest X-ray images was identified in 40 patients (7.5%, 40/535). Esophageal dysphagia was more frequent in individuals aged 65–79 years (odds ratio=4.78, p<0.05) than in those aged <65 years. Mild esophageal dysphagia was more frequent (n=32) than its severe form (n=8). Lower esophageal dysphagia was more frequent (n=31) than upper esophageal dysphagia (n=9). Esophageal residual barium in patients diagnosed with esophageal cancer or lung cancer was significantly associated with severe esophageal dysphagia (p<0.05) and at the upper esophagus level (p<0.01).Conclusion Esophageal residual barium was observed on chest X-ray imaging after VFSS. Esophageal barium in the upper esophagus with a diameter of ≥2 cm is an important indicator of malignancy, and chest X-ray image taken after VFSS is an important step to evaluate the presence of esophageal disorder.
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Akram, Bushra, und Mehak Batool. „Suicidal Behavior Among the Youth With and Without Sensory Impairment: Prevalence and Comparison“. OMEGA - Journal of Death and Dying 81, Nr. 3 (03.06.2018): 393–403. http://dx.doi.org/10.1177/0030222818779711.
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This comparative survey was conducted to explore the prevalence of suicidal behavior among the youth without sensory impairment ( n = 595) as well as youth with sensory impairment: visual impairment ( n = 537) and hearing impairment ( n = 535). Suicidal behavior of the participants were assessed by the Urdu form of Suicidal Behavior Questionnaire. Findings indicated the higher prevalence of overall suicidal behavior among the participants with visual impairment (38%) as compared with the participants with (32%) and the youth (13%) without sensory impairment. Odds ratios further confirmed these results by showing the participants with visual impairment higher on suicidal behavior. Moreover access to counseling, monthly income of the parents, and severity level of disability appeared to be positive predictors of suicidal behavior among the participants. Thus, results showed that all of the three groups are at the risk of having suicidal behavior and, therefore, careful measures are required to be taken at prevention and intervention levels.
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Aparisi, Álvaro, Cristina Ybarra-Falcón, Mario García-Gómez, Javier Tobar, Carolina Iglesias-Echeverría, Sofía Jaurrieta-Largo, Raquel Ladrón et al. „Exercise Ventilatory Inefficiency in Post-COVID-19 Syndrome: Insights from a Prospective Evaluation“. Journal of Clinical Medicine 10, Nr. 12 (11.06.2021): 2591. http://dx.doi.org/10.3390/jcm10122591.
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Introduction: Coronavirus disease 2019 (COVID-19) is a systemic disease characterized by a disproportionate inflammatory response in the acute phase. This study sought to identify clinical sequelae and their potential mechanism. Methods: We conducted a prospective single-center study (NCT04689490) of previously hospitalized COVID-19 patients with and without dyspnea during mid-term follow-up. An outpatient group was also evaluated. They underwent serial testing with a cardiopulmonary exercise test (CPET), transthoracic echocardiogram, pulmonary lung test, six-minute walking test, serum biomarker analysis, and quality of life questionaries. Results: Patients with dyspnea (n = 41, 58.6%), compared with asymptomatic patients (n = 29, 41.4%), had a higher proportion of females (73.2 vs. 51.7%; p = 0.065) with comparable age and prevalence of cardiovascular risk factors. There were no significant differences in the transthoracic echocardiogram and pulmonary function test. Patients who complained of persistent dyspnea had a significant decline in predicted peak VO2 consumption (77.8 (64–92.5) vs. 99 (88–105); p < 0.00; p < 0.001), total distance in the six-minute walking test (535 (467–600) vs. 611 (550–650) meters; p = 0.001), and quality of life (KCCQ-23 60.1 ± 18.6 vs. 82.8 ± 11.3; p < 0.001). Additionally, abnormalities in CPET were suggestive of an impaired ventilatory efficiency (VE/VCO2 slope 32 (28.1–37.4) vs. 29.4 (26.9–31.4); p = 0.022) and high PETCO2 (34.5 (32–39) vs. 38 (36–40); p = 0.025). Interpretation: In this study, >50% of COVID-19 survivors present a symptomatic functional impairment irrespective of age or prior hospitalization. Our findings suggest a potential ventilation/perfusion mismatch or hyperventilation syndrome.
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Trippel, Edward A., und Steven RE Neil. „Maternal and seasonal differences in egg sizes and spawning activity of northwest Atlantic haddock (Melanogrammus aeglefinus) in relation to body size and condition“. Canadian Journal of Fisheries and Aquatic Sciences 61, Nr. 11 (01.11.2004): 2097–110. http://dx.doi.org/10.1139/f04-125.
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Egg and larval production of 22 captive spawning pairs of northwest Atlantic haddock (Melanogrammus aeglefinus) were monitored. Females spawned an average of nine egg batches (range 316) with a mean batch fecundity of 60 000 eggs and mean total fecundity of 535 000 eggs. Mean spawning duration was 37 days with a mean batch interval of 5.4 days. In multiple linear regression, male Fulton's condition factor (range 1.101.55) and mean batch interval explained 56% of variation in fertilization rate (33% and 23%, respectively). Seasonal composite egg diameter spanned 1.371.53 mm among females. Mean egg diameter within females declined seasonally by an average of 10.4% (37% by volume). Females produced 46 larvae per gram body weight. Body weight was the single best predictor of fecundity (r2 = 0.57), with Fulton's condition factor (range 1.041.76) explaining no significant additional variation over length or weight. Length and condition explained 39% of variation in seasonal composite egg diameter (22% and 17%, respectively) and body weight independently explained 32%. Sex-specific parental condition and body size acted through large egg size and elevated fertility to enhance reproductive output. Male spawning success was more sensitive than egg production to changes in condition.
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Anita, Anita, Dwi Agustanti und Purwati Purwati. „Pijat Refleksi dan Penurunan Intensitas Nyeri pada Pasien Post Operasi Sectio Caesarea“. Jurnal Kesehatan 13, Nr. 2 (07.09.2022): 355. http://dx.doi.org/10.26630/jk.v13i2.3410.
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<p>Post Sectio Caesarea patients experience pain so they need postoperative adaptation. The pain felt by Sectio Cesarean patients comes from wounds in the abdomen. The pain usually occurs 10 to 36 hours after surgery and decreases on the third day. The purpose of this study was to determine the effect of reflexology on labor pain after a cesarean section. The research was conducted from August to October 2021, at Bhayangkara Hospital Bandar Lampung and RSIA AMC. Quasi-experimental research design with Wilcoxon signed rank. The research sample will be conducted on some 64 respondents (32 intervention respondents and 32 control respondents). Inclusion criteria for post-SC mothers, age 20-50 years, spinal anesthesia, intervention time 10 hours after post-SC, and mothers who are willing to receive reflexology. The results of the study the average score in the post-intervention foot reflexology group were 6.19 with a standard deviation of 644, the lowest pain scale was 4 and the highest pain scale was 7. The average score in the post-control group was 6.13 with a standard deviation of 535, the scale the lowest pain was 5 and the highest pain scale was 7. The results of the statistical analysis obtained showed that the p-value<0.05, and it was concluded that there was an effect of foot reflexology on reducing pain intensity in postoperative Sectio Caesarea patients. Learning recommendations add to the literature review related to foot reflexology and include in nursing services at health care institutions and further research on complementary therapies for post-op pain or palliative care.</p>
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Marconato, Laura, Silvia Sabattini, Giorgia Marisi, Federica Rossi, Vito Ferdinando Leone und Andrea Casadei-Gardini. „Sorafenib for the Treatment of Unresectable Hepatocellular Carcinoma: Preliminary Toxicity and Activity Data in Dogs“. Cancers 12, Nr. 5 (18.05.2020): 1272. http://dx.doi.org/10.3390/cancers12051272.
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Unresectable nodular and diffuse hepatocellular carcinoma (HCC) have a poor prognosis with limited treatment options. Systemic traditional chemotherapy has been only rarely reported, with unsatisfactory results. The aim of this prospective, non-randomized, non-blinded, single center clinical trial was to investigate safety profile, objective response rate, time to progression and overall survival of sorafenib in comparison with metronomic chemotherapy (MC) consisting of thalidomide, piroxicam and cyclophosphamide in dogs with advanced, unresectable HCC. Between December 2011 and June 2017, 13 dogs were enrolled: seven received sorafenib, and six were treated with MC. Median time to progression was 363 days (95% CI, 191–535) in dogs treated with sorafenib versus 27 days (95% CI, 0–68) in dogs treated with MC (p = 0.044). Median overall survival was 361 days (95% CI, 0–909) in dogs receiving sorafenib, while 32 days (95% CI, 0–235) in those receiving MC (p = 0.079). Sorafenib seems to be a good candidate for the treatment of dogs with advanced HCC, due to a benefit in disease control and an acceptable safety profile, offering a good basis on which new randomized prospective clinical trials should be undertaken to compare the efficacy and drawback of sorafenib versus MC or traditional chemotherapy.
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Durło, Grzegorz, Krystyna Jagiełło-Leńczuk, Mariusz Kormanek, Stanisław Małek und Jacek Banach. „Supplementary irrigation at container nursery“. Forest Research Papers 79, Nr. 1 (01.03.2018): 13–21. http://dx.doi.org/10.2478/frp-2018-0002.
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Abstract For the period from the 1st of May to the 30th of October 2014, the water balance for Scots pine, Norway spruce, Pedunculate oak and European beech seedlings in a plantation setting was analysed. The experiment was conducted at the container nursery in the Rudy Raciborskie Forest District, Poland. Water was supplied by natural rainfall as well as a by small-droplet irrigation system and two automatic weather stations combined with 32 rain collectors were used to monitor rainfall throughout this research. Rain gauges were located 25 cm above the metal pallets and 10 cm below the nursery containers. An average of 987 mm∙m−2 of water reached the plantation, of which 53% were provided by the irrigation system. Most water was supplied to the oak field, whereas least was given to the spruce plantations and the irrigation water amounted to 535 liters and 422 liters per square meter, respectively. The amount of water percolating through the substrate was approximately 50–65%, depending on the tree species. An average sum of evapotranspiration at the container nursery was estimated to amount to 520 mm∙m−2 during the growth season leading to a total water balance of +463 mm.
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Motkowski, Radosław, Paweł Abramowicz, Jolanta Kubalska, Bożena Mikołuć und Jerzy Konstantynowicz. „Efficacy and Safety of Statin Treatment in Children with Familial Hypercholesterolemia: Outcomes of 20 Years of Experience“. Journal of Clinical Medicine 12, Nr. 23 (21.11.2023): 7197. http://dx.doi.org/10.3390/jcm12237197.
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Background: The objective of this retrospective cohort study was to present the experience of 20-year-long comprehensive care of pediatric patients with familial hypercholesterolemia (FH) in a single academic center. Methods and Results: The study included 84 children aged 1–18 years with FH. For the whole study group, 535 medical visits were recorded. The mean follow-up period was 33.6 months. Molecular testing performed in 55 children (65%) provided genetic confirmation of the diagnosis in 36 children (43%). Twenty-seven children (32%) were treated pharmacologically with statins. Follow-up during the treatment averaged 29 months. Treatment with statins was associated with a mean reduction in total cholesterol and LDL-cholesterol levels of 24 and 33% from the baseline. Symptoms of statin intolerance occurred incidentally and did not require amendment in the treatment protocol. Significantly higher values of body weight, height, and BMI were found only among girls older than 10 years who were treated with statins. Conclusions: These data confirm a high efficacy and a good safety profile of statin treatment in children with FH, demonstrating no harm to physical development. However, there is a need for further cause-and-effect research regarding associations between long-term treatment with low-cholesterol, low-fat diets, statin therapy, and excessive weight gain.
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Buechter, Matthias, Dominik Dorn, Birte Möhlendick, Winfried Siffert, Hideo A. Baba, Guido Gerken und Alisan Kahraman. „Characteristics and Long-Term Outcome of 535 Patients with Autoimmune Hepatitis—The 20-Year Experience of a High-Volume Tertiary Center“. Journal of Clinical Medicine 12, Nr. 13 (21.06.2023): 4192. http://dx.doi.org/10.3390/jcm12134192.
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Background and aims: Autoimmune hepatitis (AIH) is a complex and progressive inflammatory liver disease characterized by immune-mediated destruction of the liver parenchyma, hypergammaglobulinemia, the presence of circulating autoantibodies, and good response to immunosuppressive therapy. Since the prevalence of AIH is relatively rare, data on the clinical course and the long-term outcome are scarce. Patients and methods: We retrospectively analyzed the data of 535 well-documented AIH patients treated at the University Hospital Essen between 2000 and 2020. Results: The majority of patients were middle-aged females (75% women, mean age 45 years) with AIH type 1 (97%). Approximately 32% of patients were diagnosed with cirrhosis due to AIH, 29% had concomitant autoimmune (predominantly autoimmune thyroiditis), and 10% had psychiatric diseases, respectively. Skin tumors were the most common malignant diseases (47% of all tumors), while hepatocellular carcinoma rarely occurred (only six cases). Overall long-term mortality and liver-associated mortality were 9.16% and 4.67%, respectively. However, long-term survival was strongly associated with disease remission. Conclusions: Although AIH is a silent disease and cirrhosis is present in many cases, a favorable long-term prognosis can be achieved by consequent immunosuppressive therapy. The incidence of (liver-associated) complications seems to be lower in comparison to other etiologies, such as viral hepatitis or NASH, and mainly depends on the long-term side effects of immunosuppressive therapy.
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Emde, Martina, Susanne Beck, Vladimir Benes, Jerome Moreaux, Anja Seckinger und Dirk Hose. „RNA-Sequencing Based Assessment of Targets, Risk and Long Term Survival for Personalized Treatment of Multiple Myeloma“. Blood 134, Supplement_1 (13.11.2019): 1801. http://dx.doi.org/10.1182/blood-2019-131159.
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Aim of our study is to implement RNA-sequencing as basis for risk adapted and targeted treatment-strategies in multiple myeloma. We establish assessment of malignant plasma cell proliferation and risk-stratification de novo (HDHRS) by RNA-sequencing, transfer microarray-based risk scores to RNA-sequencing, and report expression of actionable including immune-oncological targets. Methods. Transcriptome profiling was performed on CD138 purified malignant plasma cell samples from previously untreated symptomatic multiple myeloma patients undergoing high-dose melphalan treatment and autologous stem cell transplantation. RNA-sequencing was performed on an Illumina NextSeq500-platform using 5ng of total RNA (n=535), and, in the same cohort, by gene expression profiling using Affymetrix U133 2.0 DNA-microarrays (n=534). iFISH was performed using a ten-probe panel (n=535). Clinical data and survival of patients treated with high-dose therapy and autologous stem cell transplantation were assessed (n=534/533/534 for RNA-seq/GEP/iFISH) with median follow up of 64 months. Data were validated using the independent COMPASS cohort (n=767 pts., median follow up of 31 months). Results. RNA-sequencing is feasible in more than 90% of myeloma patients. It allows assessment of proliferation (RPI) and risk, both de novo (HDHRS) and regarding microarray-based scores (UAMS GEP70-, EMC92-, Rs-score). All scores are significantly predictive for overall and event-free survival in GEP are likewise in RNA-seq with hazard ratio for high risk to low risk group of 3.06, 4.3, 2.84, 3.93 and 3.30 in overall survival of test group. (See as example gene expression based proliferation index / RNA-seq based proliferation index, Fig. 1). The de novo RNA-seq risk stratification (HDHRS) superiorly delineates three significantly different groups of 40%, 38%, and 22% of patients with 5-year survival rates of 84%, 67%, and 32%, respectively (Fig.2). It likewise discerns a group of long term surviving patients with a survival rate of 57% and 49%, at 10 and 12 years, respectively. Targets expressed in normal plasma cells with varying expression height in malignant include BCMA and CD38, those aberrantly expressed CSF1, CD20 and HGF. Mutated actionable transcripts include BRAF V600E/K (target), the proteasome and cereblon (resistance). In conclusion, RNA-seq allows assessment of risk, long term survival and targets in multiple myeloma both in phase III multicenter trials as well as in clinical Routine. Disclosures Moreaux: Diag2Tec: Other: Co-founder of Diag2Tec company.
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Mey, W. „Common, I. F. B. (1990): Moth of Australia. - E. J. Brill (Leiden, New York, Kobenhavn, Köln); 535 S., 129 Abb., 32 Farbtafeln, Preis: 171.00 $. ISBN 90-04-092227-7“. Deutsche Entomologische Zeitschrift 38, Nr. 4-5 (22.04.2008): 364. http://dx.doi.org/10.1002/mmnd.19910380410.
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Mey, W. „Common, I. F. B. (1990): Moth of Australia. – E. J. Brill (Leiden, New York, Kobenhavn, Köln); 535 S., 129 Abb., 32 Farbtafeln, Preis: 171.00 $. ISBN 90-04-092227–7“. Deutsche Entomologische Zeitschrift 38, Nr. 4-5 (19.09.1991): 364. http://dx.doi.org/10.1002/mmnd.4800380410.
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Malasyi, Syibral. „Pengaruh pemberian jenis pakan komersial berbeda dengan penambahan Vitamin E terhadap pemijahan dan pembesaran ikan cupang (Betta sp.)“. Arwana: Jurnal Ilmiah Program Studi Perairan 3, Nr. 2 (29.11.2021): 131–40. http://dx.doi.org/10.51179/jipsbp.v3i2.672.
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Masalah yang sering dijumpai pada pemeliharaan ikan cupang terlebih pada pengembangbiakan intensif adalah kematian benih yang cukup tinggi dan perkembangan yang sangat lambat. Penggunaan pakan buatan pelet sudah banyak dilakukan namun hasilnya masih belum mencapai target. Penambahan vitamin E pada pakan buatan adalah salah satu alternatif yang dapat dilakukan untuk meningkatkan gizi pakan. Vitamin E pada pakan mampu bertindak menjadi antioksidan, yang mampu menjaga ketersediaan HUFA (Highly Unsaturated Fatty Acid) di membran sel atau mencegah radikal bebas intraseluler. Penelitian ini dilakukan untuk mengetahui pengaruh pemberian jenis pakan komersial berbeda dengan penambahan vitamin E terhadap pemijahan dan pembesaran ikan Cupang. Metode penelitian ini menggunakan Rancangan Acak Lengkap (RAL) faktorial dengan 4 perlakuan dan 3 pengulangan. Hasil penelitian didapatkan daya tetas telur ikan Cupang pada 3 perlakuan didapatkan sebesar 55% dengan jumlah telur yang dihasilkan dari 9 pasang indukan sebanyak 535 butir dan yang menetas sebesar 296 butir. Abnormalitas ikan Cupang didapatkan sebesar 11% dengan jumlah benih sebanyak 295 ekor dan benih yang abnormal sebanyak 32 ekor. Kelangsungan hidup ikan Cupang diperoleh sebesar 97% dengan jumlah benih minggu 0 sebanyak 295 ekor dan benih yang tinggal pada minggu 4 sebanyak 285 ekor dengan jumlah kematian sebanyak 10 ekor. Pertumbuhan mutlak benih ikan Cupang didapatkan rata-rata peningkatan bobot sebesar 48,02 miligram. Pertumbuhan panjang mutlak benih ikan Cupang didapatkan rata-rata peningkatan panjang sebesar 14,15 milimeter
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Couto, Gabriela Martucci, Anelise Lima de Abreu Dessimoni, Maria Lúcia Bianchi, Deise Morone Perígolo und Paulo Fernando Trugilho. „Use of sawdust Eucalyptus sp. in the preparation of activated carbons“. Ciência e Agrotecnologia 36, Nr. 1 (Februar 2012): 69–77. http://dx.doi.org/10.1590/s1413-70542012000100009.
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Wood sawdust is a solid residue, generated in the timber industry, which is of no profitable use and can cause serious environmental problems if disposed inadequately. The aim of this study was to use the eucalyptus sawdust in the preparation of activated carbons AC) and test them as adsorbents of methylene blue (MB) and phenol, representative pollutants from aqueous effluents of various industries. The eucalyptus sawdust was characterized by instrumental analysis such as elementary analysis (CHNS-O), thermogravimetric analysis (TGA), infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The activated carbons were prepared by physical activation with carbon dioxide AC_CO2, (10º C min-1, 850º C, 1h) and by chemical activation with potassium carbonate AC_K2CO3 (10º C min-1, 850º C, 3h). The AC_CO2 and AC_K2CO3 were characterized by CHN-O, TGA, FTIR, N2 adsorption/desorption (BET) to evaluate the specific surface area and SEM. The resulting activated carbons were tested for their ability to adsorb MB and phenol in water. The activated carbons produced in this work were predominantly microporous and showed specific surface area of about 535 m² g-1. The AC_K2CO3 was more effective in the adsorption of MB (81 mg g-1) and phenol (330 mg g-1) than AC_CO2 (32 mg g-1 and 172 mg g-1, respectively, for MB and phenol).
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Tjandraningsih, Dewi, und Rahul Khan. „Analysis of Legal Protection for Owners of Multiple Land Certificates Issued The Badan Pertanahan Nasional“. International Journal of Law Review and State Administration 1, Nr. 1 (20.07.2023): 15–22. http://dx.doi.org/10.58818/ijlrsa.v1i1.40.
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The research objective is to analyze the legal consequences of multiple land certificates with the same object. To study the law for holders of various certificates. To analyze the Supreme Court Decision number 1820K/Pdt/2021. The research method uses a qualitative approach that narrates events that occurred in the field. Data collection techniques through interviews with judges and plaintiffs and documentation studies in the form of archives at the supreme court. The conclusion is that the legal consequences of multiple certificates on land with the same object due to the negligence of the head of the land agency are legal uncertainty in the ownership of various certificates so that multiple certificates can be canceled through a Court Decision because they have permanent legal force (Eintracht van gewijsde), the land agency must is responsible for issuing double certificates and revoking them because they have been declared null and void. Legal protection for land certificate holders, as stated in Government Regulation no. 24 of 1997, Article 19 paragraph (2) letter c, Article 23 paragraph (2), Article 32 paragraph (2), and Article 38 paragraph (2). The certificate is valid as strong evidence; with the Supreme Court's cancellation decision Number 1820 K/Pdt/2021, with Property Rights Certificate no. 535 in Cipatujah Village, legal protection for certificate owners has yet to materialize.
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Oliveira, Maria Walcleanes Magalhães de, Júlio César Sousa Prado, Martinair Santana da Silva, Maria Gleiciane de Queiroz Martins und Francisco Cesar Barroso Barbosa. „Frequency of Multidrug-Resistant Microorganisms Associated with Bacterial Coinfections in Hospitalized Patient with Covid-19: A Literature Review“. Archives of Current Research International 24, Nr. 3 (22.02.2024): 27–37. http://dx.doi.org/10.9734/acri/2024/v24i3640.
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Patients with a doença do coronavírus 2019 (COVID-19) may be at risk of associated bacterial co-infections, and the involvement of multidrug-resistant (MDR) microorganisms in these cases can lead to an increase in morbidity and mortality rates. The objective of this study was to describe the frequency of the main MDR microorganisms associated with bacterial co-infections in patients hospitalized with COVID-19. To this end, we carried out a search in the PubMed and Regional Portal of the Virtual Health Library (VHL) databases, from December 2019 to September 2023, with the keywords COVID-19, co-infection and multidrug-resistant microorganism. Of the 535 articles initially found, only 14 were selected for analysis. Gram-negative bacteria were most frequently involved in bacterial co-infections in patients with COVID-19 (70%). Among these, Klebsiella pneumoniae and Acinetobacter baumannii predominated, with 85.71% and 78.57%, respectively. Among gram-positive bacteria, Staphylococcus aureus (71.42%) was the most common. Among MDR microorganisms, the prevalent species were carbapenem-resistant gram-negative bacilli (32%) and methicillin-resistant S. aureus (85.7%). Furthermore, a higher frequency of MDR microorganisms was observed in patients with COVID-19 in intensive care units (ICU). Thus, the findings of the present study indicate the need for attention to infections caused by multidrug-resistant microorganisms in critically ill patients with COVID-19.
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Creighton, C., J. Rae, A. Chinnaiyan und M. Lippman. „Improved prediction of disease-free survival in tamoxifen-treated patients using an expression signature of estrogen-regulated genes as compared to progesterone receptor“. Journal of Clinical Oncology 24, Nr. 18_suppl (20.06.2006): 535. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.535.
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535 Background: Progesterone receptor (PR) is a direct downstream target of activated estrogen receptor (ER) and its expression is a marker of estrogen signaling within breast tumors. Studies suggest the absence of PR predicts the likelihood of distant recurrence in patients treated with hormonal therapies such as tamoxifen, but better clinical measures are needed. Methods: Through analysis of public mRNA expression profiling datasets, we identified 36 genes with the following expression patterns similar to PR: (1) induced by 17β-estradiol (E2) in estrogen receptor (ER)-positive breast cancer cell lines in vitro, (2) under-expressed in ER-negative compared to ER-positive breast tumors, and (3) correlated with PR expression in ER-positive tumors. The average expression of these 36 genes was used as a “risk index” for assessing disease-specific survival in two independent tumor profile datasets of 60 and 67 patients treated with tamoxifen (these data not having been used to initially select the 36 genes), with a high risk group in each dataset defined as those with the bottom 25% of risk index values. Results: The Kaplan-Meier estimates of the rates of distant recurrence at 10 years in the low-risk and high-risk groups were 24% and 64% in the one dataset and 32% and 72% in the other dataset. In both validation datasets, the rate in the low-risk group was significantly lower than that in the high-risk group (P=0.008 and P=0.006 by log-rank, respectively), whereas patient groups defined by histologically-assigned PR status did not show significant risk differences (P=0.70 and P=0.94, respectively). In a univariate Cox model, the risk index combined across both validation datasets provided significant predictive power (P=0.03). Conclusions: Through RT-PCR assay of a larger independent cohort of breast tumor samples, we are currently validating the prognostic value of individual genes within the 36-gene signature. No significant financial relationships to disclose.
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Getmantseva, Lyubov, Siroj Bakoev, Olga V. Kostyunina, Alexey Traspov, Yuri Prytkov und Nekruz Bakoev. „PSVII-26 Detection of selection signatures in Civil and Large White pig breeds“. Journal of Animal Science 98, Supplement_4 (03.11.2020): 464–65. http://dx.doi.org/10.1093/jas/skaa278.808.
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Abstract The detection of selection signatures can help to understand the mechanisms of artificial selection. The purpose of this work is to determine the selection signatures in Civil pig relatively Large White breed. The research was carried out on Large White of three breeding centers (LW_1_New=16, LW_2_New=12, LW_3_New=15) and Civilskay, bred in Russia on the basis of local pigs and Large White boars, (Civil=17). GeneSeek GGP Porcine HD BeadChip (San Diego, USA) was used. A heatmap plot of genomic relationship matrix (GRM) was used to evaluate genetic variability between populations. The signals of diversifying selection were detected using Fst and Smoothing Fst (R package Lokern). QTLs and genes were identified and annotated in the Ensembl genome browser (Sscrofa 11.1) (https://www.ensembl.org/index.html), Panther 15.0 (http://www.pantherdb.org/) and QTLdb (https://www.animalgenome.org/cgi-bin/QTLdb/index).Data visualization from heatmapplot (Fig.) showed that all individuals are grouped in relation to their groups. However, the groups LW_1_New, LW_3_New and CIVIL were separated from LW_2_New. We have selected LW_1_New, LW_3_New and CIVIL to identify the selection signatures. After smoothing of the data by moving average, top 0.1% of the observations were considered as pinpointing CIVIL-specific selection signals. As a result, genome regions with strong selection signals on SSC1:214634036-217738857, SSSC2:137533941-138048506, SSC4:24655041-30832595, SSC7:27386432-28655399 and SSC8:55806826-56299366 were found. In these areas, 535 QTLs have been identified, including 347 QTLs for Meat and Carcass Traits (the majority related to Backfat), 67 QTLs Production (Average daily gain or Body weight), 62 QTLs Health (Mean corpuscular volume, Actinobacillus pleuropneumoniae susceptibility et al.), 32 QTLs Reproduction (Teat number) and 27 QTLs Exterior (Leg conformation). In general, 32 genes are defined in these regions (SSC1-11; SSC2-5; SSC4-10; SSC7-3; SSC8-3) (Table). They are mainly involved in the following biological processes: metabolic (GO:0008152), cellular (GO:0009987) and biological regulation (GO:0065007). This research was supported by the Russian Scientific Foundation (RSF) within Project No. 19-16-00109.
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Buledi, Majid Hussain, und Tunku Ahmad Tunku Badariah. „Exploring Digital Technology Usage among English Language Instructors at a Saudi Higher Education Institution and Validating a Hierarchical Structure of Usage Based on the SAMR Model“. IIUM Journal of Educational Studies 12, Nr. 1 (31.01.2024): 90–111. http://dx.doi.org/10.31436/ijes.v12i1.446.
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This study examined the usage of digital technology among English language instructors at a public university in Saudi Arabia as perceived by their students and tested the notion that such usage could be ranked in hierarchical levels. The SAMR model, developed by Puentedura (2014), was employed to categorise and rank technology usage into four incremental levels, i.e., Substitution, Augmentation, Modification and Redefinition, with Substitution being the most rudimentary level and Redefinition being the highest and most sophisticated usage. A 32-item questionnaire rated on a 5-point Likert scale measuring how frequently English language instructors used technology at the four SAMR levels was developed by the authors, content-validated by six instructional technology experts and pilot-tested with 63 students prior to its use in the actual survey. Data were gathered from a survey sample of 535 Saudi learners studying English in their foundation year programme and analysed using three statistical procedures, i.e., descriptive statistics, exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). The descriptive results pointed to instructors' technology usage revolving around the Substitution level of the SAMR model, indicating a predominant tendency among instructors to merely replace traditional teaching tools with digital alternatives. The EFA procedure (via Principal Axis Factoring with Promax rotation) produced conflicting results. While the extracted factor structure supported only two levels of usage, the scree plot suggested the existence of four usage levels consistent with the SAMR model. This was addressed by the subsequent CFA procedure performed on the data that confirmed the four SAMR levels, with the fit statistics indicating a good-fitting technology usage model; χ2(98) = 268.73; χ2/df = 2.74; CFI = .94; RMSEA = .078, CI: .067, .090. Sixteen out of the 32 technology usage items were successfully extracted and confirmed as the indicators SAMR’s four levels. The results corroborated previous findings that technology utilisation among English instructors is pervasive but rudimentary. They also supported the theoretical notion that technology usage can be categorised, ranked, and understood in hierarchical levels as purported by the SAMR model.
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Szary, Cezary, Justyna Wilczko, Michal Zawadzki und Tomasz Grzela. „Hemodynamic and Radiological Classification of Ovarian Veins System Insufficiency“. Journal of Clinical Medicine 10, Nr. 4 (08.02.2021): 646. http://dx.doi.org/10.3390/jcm10040646.
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Ovarian veins system insufficiency is one of the most common reasons for pelvic venous insufficiency (PVI). PVI is a hemodynamic phenomenon responsible for the occurrence of venous insufficiency of the lower extremities and recurrent varicose veins in nulliparous and parous women, as well as for a set of symptoms described as pelvic congestion syndrome (PCS). In the years 2017–2019, 535 patients admitted to our center with symptoms of venous insufficiency of the lower extremities, underwent complete ultrasound diagnostics (color-duplex ultrasound) of the venous system of the abdomen, pelvis and lower limbs, as well as extended imaging diagnostics using computed tomography (CT) or magnetic resonance (MR) venography. On the basis of the obtained results, the authors proposed a 4-grade hemodynamic and radiological classification (grades I-IV) defining the stratification of ovarian veins insufficiency. Using the above mentioned classification approx. 32% patients were identified as Grade I and I/II, approximately 35% revealed morphological and hemodynamic changes corresponding to Grade II and II/III, approximately 25% were classified as Grade III, whereas the remaining 8% were assessed as Grade IV. The described classification allows for the grading of ovarian veins insufficiency based on transparent radiological criteria, making it easy to use in everyday clinical practice. According to the authors, the proposed classification could facilitate communication between diagnostic physicians, specialists dealing with the treatment of venous insufficiency and gynecologists, who admit patients with symptoms suggesting venous insufficiency of the pelvis.
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Guo, Jianqing, Jing Li, Sebastien Massart, Kanglai He, Frédéric Francis und Zhenying Wang. „Analysis of the Genetic Diversity of Two Rhopalosiphum Species from China and Europe Based on Nuclear and Mitochondrial Genes“. Insects 14, Nr. 1 (06.01.2023): 57. http://dx.doi.org/10.3390/insects14010057.
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Population genetic studies can reveal clues about the evolution of adaptive strategies of aphid species in agroecosystems and demonstrate the influence of environmental factors on the genetic diversity and gene flow among aphid populations. To investigate the genetic diversity of two Rhopalosiphum aphid species from different geographical regions, 32 populations (n = 535) of the bird cherry-oat aphid (Rhopalosiphum padi Linnaeus) and 38 populations (n = 808) of the corn leaf aphid (Rhopalosiphum maidis Fitch) from China and Europe were analyzed using one nuclear (elongation factor-1 alpha) and two mitochondrial (cytochrome oxidase I and II) genes. Based on the COI-COII sequencing, two obvious clades between Chinese and European populations and a low level of gene flow (Nm = 0.15) were detected in R. padi, while no geographical-associated genetic variation was found for EF-1α in this species. All genes in R. maidis had low genetic variation, indicating a high level of gene flow (Nm = 5.31 of COI-COII and Nm = 2.89 of EF-1α). Based on the mitochondrial result of R. padi, we concluded that the long distance between China and Europe may be interrupting the gene flow. The discordant results of nuclear gene analyses in R. padi may be due to the slower evolution of nuclear genes compared to mitochondrial genes. The gene exchange may occur gradually with the potential for continuous migration of the aphid. This study facilitates the design of control strategies for these pests.
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Kvaček, Jiří, Jiřina Dašková und Milan Libertín. „Catalogue of plant fossils described in works by Kaspar M. Sternberg. Second revised edition“. Sternbergiana 1, Nr. 1 (2021): 1–309. http://dx.doi.org/10.37520/s-fi.2021.01.
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This Catalogue is the second revised and expanded edition of the first edition, published in 1997 by J. Kvaček and Straková. The material presented in the original edition was completely nomenclaturally revised and newly photodocumented. This second edition provides as much updated information as it was possible to acquire. The Catalogue includes and reviews new nomenclatural and taxonomic assignments of Sternberg’s type material and taxa published after 1997. It is clear that much of the impulse to conduct this new research came from the first edition of the Catalogue, as the community realized the type material is available for study. In summary, the second edition of the Catalogue comprises specimens that are types of 82 genera, 3 subgenera, 535 species and 14 varieties described by Kaspar Maria Count Sternberg and his collaborators: K. B. Presl and A. C. J. Corda. The type material of 32 genera, 233 species and 5 varieties is housed in the National Museum, Prague. The types of 79 species and 4 varieties have been located in other European museums. The rest of the type specimens are currently missing – destroyed, lost, or of unknown repository. For available specimens, more detailed taxonomic, stratigraphic and geographical information is provided. All cases are noted where names in Sternberg’s works have priority over names currently used, although the current names may be more widely known. Only two nomenclatural acts are published in the present work; they are designations of a lectotypes for Aspleniopteris difformis Sternb. and Cycadites salicifolius C.Presl in Sternberg.
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Guyon, Maxime, Cyrielle Chea, Davy Laroche, Isabelle Fournel, Audrey Baudet, Michel Toupet und Alexis Bozorg Grayeli. „Measuring threshold and latency of motion perception on a swinging bed“. PLOS ONE 16, Nr. 7 (09.07.2021): e0252914. http://dx.doi.org/10.1371/journal.pone.0252914.
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Introduction Our objective was to develop and to evaluate a system to measure latency and threshold of pendular motion perception based on a swinging bed. Materials and methods This prospective study included 30 healthy adults (age: 32 ± 12 years). All subjects were tested twice with a 10 min. interval. A second trial was conducted 2 to 15 days after. A rehabilitation swinging bed was connected to an electronic device emitting a beep at the beginning of each oscillation phase with an adjustable time lag. Subjects were blindfolded and auditory cues other than the beep were minimized. The acceleration threshold was measured by letting the bed oscillate freely until a natural break and asking the patient when he did not perceive any motion. The perception latency was determined by asking the patient to indicate whether the beep and the peak of each oscillation were synchronous. The time lag between sound and peak of the head position was swept from -750 to +750 ms by 50 ms increments. Results The mean acceleration threshold was 9.2±4.60 cm/s2. The range width of the synchronous perception interval was estimated as 535±190 ms. The point of subjective synchronicity defined as the center of this interval was -195±106 ms (n = 30). The test-retest evaluation in the same trial showed an acceptable reproducibility for the acceleration threshold and good to excellent for all parameters related to sound-movement latency. Conclusion Swinging bed combined to sound stimulation can provide reproducible information on movement perception in a simple and non-invasive manner with highly reproducible results.
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Simental-Mendía, Luis E., Rita Gómez-Díaz, Niels H. Wacher und Fernando Guerrero-Romero. „The Triglycerides and Glucose Index is Negatively Associated with Insulin Secretion in Young Adults with Normal Weight“. Hormone and Metabolic Research 54, Nr. 01 (Januar 2022): 33–36. http://dx.doi.org/10.1055/a-1713-7821.
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AbstractSeveral studies have supported the usefulness of the triglycerides and glucose (TyG) index as a surrogate measure of insulin resistance; however, it has not been evaluated in insulin secretion. The aim of this study was to assess the association between the TyG index and insulin secretion in young adults with normal weight. Apparently healthy non-pregnant women and men, aged 18 to 23 years, were enrolled in a cross-sectional study. Overweight, obesity, pregnancy, smoking, alcohol consumption, diabetes, liver disease, renal disease, cardiovascular disease, and neoplasia were the exclusion criteria. Normal weight was defined by a body mass index (BMI)≥18.5<25.0 kg/m2 and the TyG index was calculated as the Ln [fasting triglycerides (mg/dl) x fasting glucose (mg/dl)]/2. A total of 1676 young adults with normal-weight, 1141 (68%) women, and 535 (32%) men were enrolled. Of them, 269 (16%) individuals exhibited insulin resistance; 213 (12.7%) women and 56 (3.3%) men. The linear regression analysis adjusted by gender, BMI, and waist circumference showed a significant association between the TyG index and HOMA-B (B=−35.90; 95% CI:−68.25 to−3.54, p=0.03) in the overall population. An additional analysis adjusted by BMI and waist circumference revealed that the TyG index is significantly associated with HOMA-B in subjects with and without insulin resistance (B=−104.73; 95% CI:−204.28 to−5.18, p=0.03 and B=−74.72; 95% CI:−108.04 to−41.40, p<0.001). The results of this study showed that the TyG index is negatively associated with insulin secretion in young adults with normal weight.
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Rothwell, Peter M., und Charles P. Warlow. „Familial frequency of ischaemic stroke and transient ischaemic attack in relation to clinical subtype and intermediate phenotypes“. Stroke 32, suppl_1 (Januar 2001): 321. http://dx.doi.org/10.1161/str.32.suppl_1.321-a.
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28 Susceptibility to cerebral ischaemia is influenced by genetic factors. However, although a number of rare Mendelian syndromes have been characterised, there have been few studies of the genetic epidemiology of the common forms of ischaemic stroke and TIA. Previous studies have not reported familial frequency in the specific clinical subtypes of ischaemic stroke, and have not assessed the extent to which familial susceptibility is related to intermediate phenotypes such as hypertension, diabetes and hyperlipidaemia. We studied family history of stroke in 544 ischaemic strokes (Oxfordshire Community Stroke Project: OCSP) and 469 TIAs (hospital-referred case series in Oxford). Information on history of stroke in first degree relatives (FDR) was obtained in 535 stokes and 467 TIAs. Stroke had occurred in a FDR of 40 (8%, 95% CI = 6 - 10) stroke cases. Positive family history was unrelated to clinical subtype (OCSP classification). In particular, it was no more common in lacunar than non-lacunar stroke. In the TIAs, there was a history of stroke in at least one FDR in 98 (21%, 95% CI = 17 - 25) cases: 80 (17%) with one FDR, 16 (3.4%) with two FDRs and 2 (0.4%) with 3+ FDRs. The frequency of hypertension increased with the number of FDRs affected (P=0.003): nil - 105/373 (28%), one - 32/78 (41%); two or more - 12/18 (67%). Mean (SD) systolic blood pressure (mmHg) also increased across these groups (P=0.02): 157 (31), 162 (30) and 177 (36). In the strokes, a history of hypertension was also more frequent in those with a family history of stroke (P=0.02), and this was also shown by differences in measured blood pressure. In both cohorts, cases without hypertension, diabetes or hyperlipidaemia were least likely to have a family history of stroke. A history of stroke in a FDR was relatively infrequent, and was not related to the clinical subtype of stroke. However, in both the strokes and TIAs, family history of stroke was strongly related to intermediate phenotypes, particularly hypertension. These data suggest that genetic susceptibility to hypertension might account for a substantial proportion of the familial clustering of ischaemic stroke and TIA.
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Fedorych P. V. und Mavrov G. I. „INCIDENCE OF SEXUALLY TRANSMITTED INFECTIONS: LOCAL STUDY IN UKRAINE“. World Science 2, Nr. 8(36) (31.08.2018): 4–7. http://dx.doi.org/10.31435/rsglobal_ws/30082018/6059.
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Introduction.The structure of incidence of sexually transmitted infections is changing constantly. Information on such changes supports correct planning of clinical and diagnostic activities of institutions providing specialized medical care by qualified specialists.Objective:to investigate the prevalence of sexually transmitted infections with pathogens clinically significant to the genitourinary system in Ukraine and at the local level.Materials and methods. Polymerase chain reaction was used to test the biological material obtained from the genitourinary clinical specimens from subjects with sexually transmitted infections, who underwent clinical and laboratory examinations in Oleksandrivsk Clinical Hospital (Kyiv, Ukraine) for Chlamydia trachomatis, Mycoplasma hominis, Mycoplasma genitalium, Ureaplasma urealyticum, Trichomonas vaginalis, Human papillomavirus, and Neisseria gonorrhoea. During 2017, 607 subjects of both genders, including 295 (48.6%) females and 312 (51.4%) males, were examined. Their mean age was 32±3.5.Findings. Chlamydia trachomatis was found in 159 (26.2%) of 607 examined subjects – 85 males and 74 females. Mycoplasma hominis was found in 122 of 585 (21.1%) examined subjects – 64 males and 58 females. Mycoplasma genitalium, respectively, in 17 (6.62%) of 258 subjects – 6 males and 11 females. Ureaplasma urealyticum was found in the largest number of subjects (305, i.e. in 48.77% of 601 examined subjects) – 157 males and 148 females. Trichomonas vaginalis was found in 28 (5.23%) of 535 subjects – 15 males and 13 females. Human papillomavirus was found in 158 of 297 (53.2%) examined subjects – 88 males and 70 females. Neisseria gonorrhea was found in 33 of 297 (8.45%) subjects – 8 males and 25 females.Conclusions. As suggested by the local study of the sexually transmitted infections incidence in Ukraine, the most clinically significant for the genitourinary system are Human papillomavirus (53.2%), Ureaplasma urealyticum (48.77%), Chlamydia trachomatis (26.2%) and Mycoplasma hominis (21.1%). Therefore, tests for these pathogens in the specified region is currently the most appropriate during diagnostic examinations and counselling of subjects with genitourinary infections.
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Leggiero, Nicole, Terri Armstrong, Elizabeth Vera, Mark Gilbert und Amanda King. „QOLP-28. THE USE OF VIRTUAL REALITY FOR SYMPTOM MANAGEMENT: APPLICATION IN NEURO-ONCOLOGY“. Neuro-Oncology 21, Supplement_6 (November 2019): vi203—vi204. http://dx.doi.org/10.1093/neuonc/noz175.848.
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Abstract Patients with primary central nervous system (CNS) tumors are highly symptomatic due to the functional sequelae of their disease and an unfavorable prognosis. Virtual reality (VR) immersive technology has demonstrated benefit in improving patients’ symptom burden, such as distress, pain, anxiety, and fatigue. However, this has not been explored in a CNS tumor population. This project explored the potential use of VR for symptom management in CNS tumor patients. A descriptive analysis of MDASI-BT/MDASI-SP/PROMIS-Anxiety patient-reported outcomes (PROs) for 535 CNS tumor patients was performed to identify the common moderate-severe (> 4 on a 0–10 scale) symptoms. Additionally, a systematic review of literature was performed addressing the question “For adult patients with solid tumors, what effect does VR have on their self-reported symptoms, such as distress, anxiety and pain?” The systematic literature review resulted in 17 studies using VR in other solid tumor populations, which demonstrated improvement in pain, anxiety, and distress. However, study designs often lacked rigor and none incorporated any biomarkers to correlate with PROs. CNS tumor symptom review of our patient cohort revealed that the majority of the patients were Caucasian (83%) males (58%) with a median age of 50 years (range, 18–83). At the time of diagnosis, 35% had a gross total resection. Glioblastoma was the most common diagnosis (32%) and 50% had a high-grade glioma. The most prevalent moderate-severe symptoms in this sample was fatigue (34%), with (14%) anxiety, (18%) pain, and (19%) distress. Given the high symptom rate in our patients, the promising but limited data that VR technology could improve distress and other symptoms provides strong support for this intervention in the CNS tumor population. Further research is needed to assess feasibility and efficacy of VR, as well as incorporation of correlative biomarkers, to better determine potential improvement in patient symptom burden.
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Mohammad, Hasan R., Stefano Campi, James A. Kennedy, Andrew Judge, David W. Murray und Stephen J. Mellon. „Long-term in vivo wear of different bearing types used for the Oxford Unicompartmental Knee Replacement“. Bone & Joint Research 8, Nr. 11 (November 2019): 535–43. http://dx.doi.org/10.1302/2046-3758.811.bjr-2019-0163.r1.
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Objectives The aim of this study was to determine the polyethylene wear rate of Phase 3 Oxford Unicompartmental Knee Replacement bearings and to investigate the effects of resin type and manufacturing process. Methods A total of 63 patients with at least ten years’ follow-up with three bearing types (1900 resin machined, 1050 resin machined, and 1050 resin moulded) were recruited. Patients underwent full weight-bearing model-based radiostereometric analysis to determine the bearing thickness. The linear wear rate was estimated from the change in thickness divided by the duration of implantation. Results The wear rate for 1900 resin machined (n = 19), 1050 machined (n = 21), and 1050 moulded bearings (n = 23) were 60 µm/year (sd 42), 76 µm/year (sd 32), and 57 µm/year (sd 30), respectively. There was no significant difference between 1900 machined and 1050 machined (p = 0.20), but 1050 moulded had significantly less wear than the 1050 machined (p = 0.05). Increasing femoral (p < 0.001) and tibial (p < 0.001) component size were associated with increasing wear. Conclusion Wear rate is similar with 1050 and 1900 resin, but lower with moulded bearings than machined bearings. The currently used Phase 3 bearings wear rate is low (1050 moulded, 57 µm/year), but higher than the previously reported Phase 2 bearings (1900 moulded, 20 µm/year). This is unlikely to be due to the change in polyethylene but may relate to the minimally invasive approach used with the Phase 3. This approach, as well as improving function and thus increasing activity levels, may increase the risk of surgical errors, such as impingement or bearing overhang, which can increase wear. Surgeons should aim to use 4 mm thick bearings rather than 3 mm thick bearings in young patients, unless they are small and need conservative bone resections. Cite this article: Bone Joint Res 2019;8:535–543.
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Andriichuk, T. P., A. Ya Senchuk und D. A. Martynova. „ДІАГНОСТИКА ТА КОРЕКЦІЯ МАГНІЄВОГО ДЕФІЦИТУ У ВАГІТНИХ ІЗ ОБТЯЖЕНИМ ГІНЕКОЛОГІЧНИМ АНАМНЕЗОМ“. Актуальні питання педіатрії, акушерства та гінекології, Nr. 1 (11.06.2019): 38–42. http://dx.doi.org/10.11603/24116-4944.2019.1.10172.
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Мета дослідження – виокремлення пацієнток із клінічними ознаками дефіциту магнію серед вагітних із групи ризику розвитку прееклампсії і вивчення ефективності застосування в них препаратів магнію для профілактики прееклампсії.
Матеріали та методи. Нами здійснені обстеження і комплексна пероральна магнієва профілактика пізнього гестозу у 100 вагітних (I група) із групи ризику виникнення цього ускладнення вагітності. Результати порівнювали із даними спостереження за 50-ма вагітними (II група) з групи ризику виникнення прееклампсії, яким до профілактичного комплексу пероральні препарати магнію не додавали. Контрольну групу (КГ) склали 50 здорових жінок із фізіологічним перебігом вагітності. Наявність дефіциту магнію визначали за результатами вивчення даних опитування, зафіксованих у розробленій нами анкеті для дослідження дефіциту магнію у вагітних. Магнієву монопрофілактику прееклампсії здійснювали такими препаратами:
Магнію оксид легкий 342 мг і магнію карбонат легкий 670 мг, що відповідає 365 мг іонів Mg++ – по 1 шипучій таблетці на добу переривчастими курсами – у 10–12; 22–26; 30–32 тижні вагітності.
Мікрогранульований порошок магнію оксид, 535 мг, що відповідає 300 мг магнію і магнію оксиду легкого 403,0–435,2 мг, що відповідає іонам магнію 243 мг. Препарати призначали з 10 тижнів протягом усієї вагітності по 1 таблетці 1 раз на добу.
Результати дослідження та їх обговорення. Результати профілактичного застосування пероральних препаратів магнію показали високу ефективність, нешкідливість і гарну переносимість запропонованої терапії порівняно із загальноприйнятими підходами (протокол МОЗ). У групі вагітних, які використовували препарати магнію (I група), значно меншою була частота загрози переривання вагітності та плацентарної дисфункції. Ефективність профілактики прееклампсії становила 96,0 % у I групі і тільки 68,0 % у групі пацієнток, яким профілактика прееклампсії здійснювалась за протоколом (II група).
Висновки. Визначено, що пацієнтки із групи ризику розвитку прееклампсії потребують призначення препаратів магнію, корекції способу життя та харчування. Профілактичний прийом препаратів магнію пацієнтками з групи ризику розвитку прееклампсії є високоефективним, нешкідливим і гарно переноситься. Ефективність профілактики прееклампсії становить 96,0 %.
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BOSTRÖM, U., M. HANSSON und H. FOGELFORS. „Weeds and yields of spring cereals as influenced by stubble-cultivation and reduced doses of herbicides in five long-term trials“. Journal of Agricultural Science 134, Nr. 3 (Mai 2000): 237–44. http://dx.doi.org/10.1017/s0021859699007662.
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The influence of herbicides at reduced rates and repeated stubble-cultivation on weeds and crop yields was estimated in five field trials with spring-sown cereals situated in the south of Sweden during the autumn of 1989 until the spring of 1997. Stubble-cultivation was accomplished during 1989–1996, while herbicides were applied at 0, 1/8, 1/4 or 1/2 of full dose during 1990–1996.In the spring of 1997, i.e. after 7 years without herbicide application, seedling densities 3 weeks after weed emergence were 68–340/m2 at three sites and 535–610/m2 at two sites when averaged over tillage treatments.Averaged over herbicide doses, stubble-cultivation reduced the plant density of annual broad- leaved weeds by 6–32% at three sites and increased the density by 25% at one site. At the remaining site, the density was not significantly influenced. Stubble-cultivation reduced the populations of two perennial and seven annual weed species, while one species was stimulated and nine species showed null, or inconsistent, responses. In the spring of 1997, i.e. one year after the last herbicide application, the densities of weed seedlings in 1/8, 1/4 and 1/2-doses were 34, 46 and 56% lower, respectively, than in the untreated controls.Stubble-cultivation increased crop yields at four sites by 200 kg/ha as a mean over herbicide doses. At these four sites, averaged over 1993–1995, herbicides increased yields in plots that were not stubble-cultivated by 7, 8 and 10% in the 1/8, 1/4 and 1/2 of a full dose, respectively, relative to the untreated control. In 1996, herbicides increased yields at only two sites.It is concluded that a fruitful way for weed management with a low input of agrochemicals is to combine the use of herbicides at reduced rates with repeated stubble-cultivation.
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Wingert, Aireen, Jennifer Pillay, Dorothy L. Moore, Samantha Guitard, Ben Vandermeer, Michele P. Dyson, Angela Sinilaite, Matthew Tunis und Lisa Hartling. „Fardeau de la maladie chez les nourrissons et les jeunes enfants hospitalisés pour le virus respiratoire syncytial : un examen rapide“. Relevé des maladies transmissibles au Canada 47, Nr. 09 (10.09.2021): 420–41. http://dx.doi.org/10.14745/ccdr.v47i09a05f.
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Les infections par le virus respiratoire syncytial sont fréquentes chez les jeunes enfants et représentent un fardeau important pour les patients, leurs familles et le système de santé canadien. Nous procédons ici à un examen rapide du fardeau lié au virus respiratoire syncytial chez les enfants âgés de 24 mois ou moins. Quatre bases de données (Medline, Embase, Cochrane Database of Clinical Trials, ClinicalTrials.gov de 2014 à 2018), la littérature grise et les listes de référence ont été examinées pour trouver des études portant sur les éléments suivants : enfants avec ou sans facteur de risque, sans prophylaxie et avec une infection par le virus respiratoire syncytial confirmée en laboratoire. Sur les 29 études trouvées, 10 ont fourni des comparaisons intraétudes et peu ont fait l’examen des conditions cliniques autres que la prématurité. Pour les nourrissons âgés de 33 à 36 semaines de grossesse (SG) par rapport aux nourrissons nés à terme, il existe des preuves de certitude faible à modérée d’une augmentation des hospitalisations dues au virus respiratoire syncytial (n = 599 535 nourrissons; RR 2,05 [IC 95 % 1,89 à 2,22]; 1,3 de plus pour 100 [1,1 à 1,5 de plus]) et de la durée d’hospitalisation (n = 7 597 nourrissons; différence moyenne de 1,00 jour [IC 95 % 0,88 à 1,12]). Il y avait des preuves de certitude faible à modérée d’une différence faible à nulle entre les nourrissons nés entre 29 à 32 SG et ceux nés entre 33 à 36 SG pour l’hospitalisation (n = 12 812 nourrissons; RR 1,20 [IC 95 % 0,92 à 1,56]). Il existe des preuves de faible certitude d’une ventilation mécanique accrue pour les nourrissons hospitalisés nés à 29 à 32 SG par rapport à 33 à 35 SG (n = 212 nourrissons; RR 1,58; IC 95 % 0,94 à 2,65). Chez les nourrissons nés entre 32 et 35 SG, l’hospitalisation pour le virus respiratoire syncytial dans la petite enfance peut être associée à une augmentation de la respiration sifflante et de l’utilisation de médicaments contre l’asthme au cours du suivi de six ans (RR de 1,3 à 1,7). Les enfants atteints du syndrome de Down peuvent avoir une durée d’hospitalisation plus longue que ceux qui n’en sont pas atteints (n = 7 206 enfants; différence moyenne de 3,00 jours, IC 95 % 1,95 à 4,05; certitude faible). Les preuves pour les autres comparaisons intraétudes étaient d’un niveau de certitude très faible. En résumé, la prématurité est associée à un risque plus élevé d’hospitalisation pour le virus respiratoire syncytial et à une durée d’hospitalisation plus longue, et le syndrome de Down peut être associé à une hospitalisation plus longue pour le virus respiratoire syncytial. L’hospitalisation due au virus respiratoire syncytial dans la petite enfance peut être associée à une plus grande respiration sifflante et à une plus grande utilisation de médicaments contre l’asthme dans la petite enfance. L’absence de groupe de comparaison a constitué une limite majeure pour de nombreuses études.
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Wakeman, R., R. Ainley, I. D. Arnott, K. J. Barrett, G. Bell, S. Berry, G. Bhatnagar et al. „P129 IBD care in the UK: A comprehensive, novel service assessment with feedback from 10,222 patients and 166 NHS organisations to inform a vision for quality improvement“. Journal of Crohn's and Colitis 15, Supplement_1 (01.05.2021): S220—S221. http://dx.doi.org/10.1093/ecco-jcc/jjab076.256.
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Abstract Background The IBD Benchmarking Tool, comprising an online Service Self-Assessment and Patient Survey, has provided a unique and comprehensive picture of Inflammatory Bowel Disease (IBD) care across the UK. The aim was to evaluate current local service performance to facilitate future quality improvement. Methods The IBD Patient Survey (PS) ran from July to November 2019 and the Service Self-Assessment (SSA) from October 2019 to January 2020. Detailed views were collected of the quality of IBD care from patient and clinician perspectives, measured against the UK IBD Standards 2019.1 The IBD UK National Report will be published in April 2021. Results 10,222 patients completed the PS. 89% (9,100/10,222) had found it hard to cope with having Crohn’s or Colitis over the previous year. 72% (6,954/9,640) rated the quality of their care as excellent, very good or good and 28% (2,686/9,640) rated the quality of their care as fair or poor. The top three factors that predicted how highly people with IBD rated their quality of care were: feeling supported by a team of specialists; having regular reviews; and discussing wider life goals and priorities, as part of planning their care. 26% (535/2,089) had waited more than a year for their diagnosis. 41% (849/2,087) had visited Accident & Emergency at least once before being diagnosed. 32% (656/2,057) were not offered any information about their condition when diagnosed. 91% (8,284/9,099) did not have a personalised care plan. Over the previous 12 months, 70% (6,732/9,574) had one or more flares and 72% (1,622/2,250) of inpatient admissions were unplanned. A key finding from the SSA (166 centres: 134 adult, 32 paediatric) was that no adult IBD services reported meeting the IBD Standards’ recommendation for whole time equivalent (WTE) staffing across the IBD team. Where services reported meeting the WTE for IBD nurse specialists, patients were more likely to rate the quality of their care highly and to have regular clinical review of their Crohn’s or Colitis. Conclusion The results highlight four key areas for change: improvements in diagnosis and information provision; personalised care and support for self-management; faster access to specialist advice and treatment; and effective multidisciplinary team (MDT) working. The Report sets out recommendations for action in each of these areas. To our knowledge, this is the first time that healthcare professionals and patients have assessed care against a common set of standards. The IBD Benchmarking Tool provides location-matched service performance and patient experience as an exemplar for others to follow. Reference
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Wang, Qi, Danrong Li, Wei Zhang, Bujian Tang, Qingdi Quentin Li und Li Li. „Evaluation of Proteomics-Identified CCL18 and CXCL1 as Circulating Tumor Markers for Differential Diagnosis between Ovarian Carcinomas and Benign Pelvic Masses“. International Journal of Biological Markers 26, Nr. 4 (Juli 2011): 262–73. http://dx.doi.org/10.5301/jbm.2011.8616.
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A lack of sensitive and specific tumor markers for early diagnosis and treatment is a major cause for the high mortality rate of ovarian cancer. The purpose of this study was to identify potential proteomics-based biomarkers useful for the differential diagnosis between ovarian cancer and benign pelvic masses. Serum samples from 41 patients with ovarian cancer, 32 patients with benign pelvic masses, and 41 healthy female blood donors were examined, and proteomic profiling of the samples was assessed by surface-enhanced laser desorption/ionization time-of-flight (SELDI-TOF) mass spectroscopy (MS). A confirmatory study was also conducted with serum specimens from 58 patients with ovarian carcinoma, 37 patients with benign pelvic masses, and 48 healthy women. A classification tree was established using Biomarker Pattern Software. Six differentially expressed proteins (APP, CA 125, CCL18, CXCL1, IL-8, and ITIH4) were separated by high-performance liquid chromatography and identified by matrix-assisted laser desorption/ionization (MALDI)-MS/MS and database searches. Two of the proteins overexpressed in ovarian cancer patients, chemokine CC2 motif ligand 18 (CCL18) and chemokine CXC motif ligand 1 (CXCL1), were automatically selected in a multivariate predictive model. These two protein biomarkers were then validated and evaluated by enzyme-linked immunosorbent assay (ELISA) in 535 serum specimens (130 ovarian cancer, 64 benign ovarian masses, 36 lung cancer, 60 gastric cancer, 55 nasopharyngeal carcinoma, 48 hepatocellular carcinoma, and 142 healthy women). The combined use of CCL18 and CXCL1 as biomarkers for ovarian cancer had a sensitivity of 92% and a specificity of 97%. The multivariate ELISA analysis of the two putative markers in combination with CA 125 resulted in a sensitivity of 99% for healthy women and 94% for benign pelvic masses, and a specificity of 92% for both groups; these values were significantly higher than those obtained with CA 125 alone (P<0.05). We conclude that serum CCL18 and CXCL1 are potentially useful as novel circulating tumor markers for the differential diagnosis between ovarian cancer and benign ovarian masses.
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Pochukalin, A. Ye, S. V. Pryima und O. V. Rizun. „DIACHRONIC DEVELOPMENT OF LOCAL LINES AND RELATED GROUPS OF BROWN CARPATIAN CATTLE FOR GENERATIONS“. Animal Breeding and Genetics 59 (04.05.2020): 142–59. http://dx.doi.org/10.31073/abg.59.16.
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In domestic theory of breeding line breeding takes the leading place, because it uses the valuable genetic material of the bull’s leaders. Numerous studies have continuously monitored the economically beneficial traits of animals of different lines, both within breeding herds and in the general breed population.
The Brown Carpathian cattle of the combined direction of productivity were officially recognized as breed and, accordingly, had all components of the breed structure (local lines and families). It should be noted that this breed has disappeared taking into account the fact that there has been no active (breeding) population since 2011.
The purpose of the study is the schematic location of the bulls of the Brown Carpathian breed lines in generations, as well as the characterization of line extensions indicating the production of mothers.
The material of the study was the State Books of Breeding Animals of eight volumes (1948, 1968, 1972, 1975, 1978, 1983, 1987 and 1992). Catalogs of dairy breed bulls for 1985–1988 were also used to evaluate the bull’s lines and groups.
Since 1972 (the time of the official recognition of the breed) and until now (in the form of genetic material that is concentrated in cryobanks) the Brown Carpathian breed has the following local lines and related groups: Pishty 10 KAZ-67, Malchyka 3 KAZ-145, Shoni 6 KAZ-81, Fitsko 33 KAZ-107, Yury 32–Iuvelira 273, Kaplara 43 KAZ-9, Sokola 553 KAZ-182, Siroho 1759 KAZ-70, Bondi 101 KAZ-25 and Muki 100 KAZ-22 and Valsa 1205 KAZ-171. The total number of bulls under study is 535 heads, including the 1st generation – 109 heads, the II generation – 111 goals, III generation – 126 goals, IV generation – 99 goals, V generation – 65 goals, VI generation – 24 goals. and VII generation – 1 head. The investigated bulls were born during 1939… 1990 years.
The related group of bull Bondi 101 KAZ-25 in the genealogical structure of the Brown Carpathian breed did not spread. The main reason was the small number of bulls. The bull was born in 1948 in the collective farm. Lenin of Mukachevo district of Zakarpattia region.
Kappa’s 43 KAZ-9 local line. The ancestor of the line was born in 1944 and came from bull Shoni 2 and Montsii (8–300–4800–3.84). The live weight at the age of Kaplar 43 was 920 kg at the age of 11 with 82 points for the exterior.
Local line of Malchyka 3 KAZ-145. The line's founder was born in 1948 and belonged to the collective farm. Dimitrov Mukachevo district of Zakarpattia region. Its origin is unknown.
The Sokol’s 553 KAZ-182 local line. The founder of the line was born in 1949 and belonged to the collective farm "For a new life" of the Irshava district of Zakarpattia region. Its high live weight (5 years 840 kg) and body dimensions (height at the withers 145 cm, oblique torso length 180 cm, girth of the breast 220 and pestle 21 cm) ensured the animal’s mass.
The related group of bull Muki 100 KAZ-22. The founder of the factory line was born in 1949 and had a brown suit and belonged to the collective farm. Chapayev. It was born of the Malyny 719, which received 4922 kg of milk for the fourth lactation and the bull Buki 220 of the Brown Swiss breed.
The related group of bull Siroho 1759 ZCP-70. The founder of the bull Siryi 1759 was born in 1962 year. The live weight of 920 kg bull at the age of 5 years with 85,5 points for the exterior.
The local line of Fitsko 33 KAZ-107. Bull Fitsko 33 has brown suit, was born in 1948, and belonged Zakarpattia Regional Agricultural Research Station. In the 12 years of its live weight was 840 kg.
The local line of Pishty 10 KAZ-67. Pishty 10, the line's ancestor, was born in 1947 and was brown. He was born to a high-yielding cow Senesha 10, from which 2 lactations received 6240 kg milk of 3.7% fat, and bull Shandora 1.
The Shoni 6 KAZ-81 local line is one of the leading in the Brown Carpathian breed. The ancestor of the line was born in 1949 from cow Fania 171, which for the 4th lactation yielded 4800 kg of milk with a fat content of 3.7% and the Fidelio bull of the Brown Swiss breed.
The local line of the Yuri 32 KAZ-8-Yuvelira 273 KAZ-162 is the most numerous and branched in the Brown Carpathian breed. The ancestor of the lineage bull Yura 32 was born in 1943 from the cow of Cavia 517, from which for the 2nd lactation received 3014 kg with a fat content of 3.75%. Its live weight at 4 years was 850 kg.
The related group of bull Valsa 1205 KAZ-171. The founder of Valsa 1205 was born in 1961 years. At 2 years of age, it had a live weight of 545 kg and a high exterior rating of 90.5 points. It came from Venetsia 564 (3–299–4416–3,6) and the Brown Swiss bull Iltis 7623.
The genealogical structure of line breeding and related groups is presented covering the period of the birth of the bulls during 1939 ... 1990 and has 535 goals. During this time, local lines were tested and related groups were formed. The production lines of Pishta 10, Fitzko 33, Shoni 6 and Yury 32-Yuvelira 273, were the most numerous, and the number of bulls in each exceeded 70 goals. Less numerous (›6 goals) were the related groups of the Bondi 101 and Valsa 1205. Each group related to the ancestor has its twigs and branches.
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Nasreen, Shaikh Zinnat Ara, Shafinaz Shahreen und Shahnaz Rahman. „Is There any Difference of Climacteric Symptoms between Natural and Surgical Menopause?“ Journal of SAFOMS 1, Nr. 2 (2013): 63–65. http://dx.doi.org/10.5005/jp-journals-10032-1014.
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ABSTRACT Objective To compare the effects of the natural and the surgical menopause (SM) on climacteric condition. Materials and methods This prospective study was conducted from Jan 2008 to Jan 2013 in ZHSWMCH. Initially, 4,000 women were enrolled but finally 1,743 of natural menopause (NM) and 554 of SM were analyzed. All women were aged between 45 and 50 years, and they were of menopause for 1 to 5 years. Ethical and patient's permission was taken. Once enrolled, they were asked questions. The questions were related to menopausal symptoms (MS). Data was collected and analyzed by SPSS software. Results Hot flushes, (535 vs 290, p < 0.001), sweating (344 vs 122, p < 0.001), poor memory (99 vs 65 p < 0.001), feeling depressed (335 vs 126, p < 0.001), dry skin/mucosa (229 vs 91, p < 0.001), decreased libido (289 vs 117, p < 0.001), dry vagina (99 vs 65, p < 0.001) and urinary complains (59 vs 42, p < 0.001) were found in SM vs NM. Hypertension or cardiovascular disease was more (191 vs 92, p < 0.01), blood sugar were more (90 vs 32, p ≤ 0.001) and metabolic syndrome are also more (48 vs 26, p < 0.07) in SM than NM but this did not reach the significance. Conclusion Menopausal symptoms are common in both NM and SM. These MS were significantly higher in surgically menopause women and they were troubled more, so we need to be cautious about oophorectomy, and ovarian preservation should be the aim in all benign cases. Of course, we need to assess the risks and benefit where there is risk of ovarian cancer during the time of total abdominal hysterectomy. Both hormone replacement therapy (HRT) (following a risk/benefit analysis) and treatment of osteoporosis may be recommended after surgery to decrease the climacteric symptoms and osteoporosis in women with menopausal symptoms. How to cite this article Nasreen SZA, Shahreen S, Rahman S. Is There any Difference of Climacteric Symptoms between Natural and Surgical Menopause? J South Asian Feder Menopause Soc 2013;1(2):63-65.
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Obosu, J. K., J. S. Y. Kuma und W. K. Buah. „Estimation of the Quantity of Water in the Abandoned Underground Mine of Gold Fields Ghana Limited Tarkwa: A Potential Source to Augment Water Supply to Tarkwa Municipality“. Ghana Mining Journal 19, Nr. 1 (30.06.2019): 9–20. http://dx.doi.org/10.4314/gm.v19i1.2.
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The Tarkwa district is an important gold mining area in the Southwestern part of Ghana. The main source of potable water supply to the Tarkwa Nsuaem Municipality is from the Bonsa River treatment plant managed by the Ghana Water Company Limited (GWCL). The River is under threat from serious contamination by illegal mining ("galamsey") activities within its catchment area. Consequently, the amount of water supplied to the Municipality has not kept pace with its growing population due to increasing treatment cost and supply difficulties. The need to find alternative and sustainable sources of potable water supply to augment that from GWCL to the Municipality has become imperative. A large void volume created as a result of the abandoned underground mine operated by Gold Fields Ghana Limited (GFGL), after its closure in 1999 has flooded. This potential water resource is being pumped out daily, and wasted, sometimes spilling-over to low lying areas around the mine when allowed to reach its decant level. This study estimated the quantity of water in the Abontiakoon Vertical Shaft (AVS) which is part of the large underground void using survey production figures and post-closure void filling parameters resulting in 2.8 x 106 m3 and 2.9 x 106 m3 respectively. The rate of recharge to the underground water was also estimated to ascertain the sustainability of the void water should it be considered for use by employing the model of predicting rebound on “void filling” basis and average dewatering rate before closure at 2 535 m3/day and 2 618 m3/day respectively; indicating that recharge to the AVS reservoir is about 6 x 106 gal/day or 30% of current daily water supply deficit in the TNM. The estimated potential volume of mine water in storage in the entire Tarkwa underground void is 32 x106 m3. Two samples of the mine water were taken in November 2011 and February 2015 for quality analysis, in order to have a fair knowledge of the water quality parameters. The quality of the underground water was found to be potentially good, and not likely to cause any health threats, or water quality problems. Depth sampling is recommended to determine the chemical profile of the reservoir. Keywords: Reservoir, Municipality, Bonsa River, Contamination, Tarkwa
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Toro-Rendón, Luis Guillermo. „Infección por el virus de la Hepatitis B en el embarazo“. Revista Médicas UIS 31, Nr. 2 (21.08.2018): 49–56. http://dx.doi.org/10.18273/revmed.v31n2-2018006.
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Introducción: la infección por el virus de la hepatitis B constituye un importante problema de salud pública a nivel mundial, pues genera una gran carga de morbilidad y mortalidad relacionada con cirrosis y hepatocarcinoma. En áreas de alta prevalencia la transmisión vertical constituye una fuente importante de infección. Objetivo: revisar la presentación de la infección por virus de la hepatitis B en el embarazo y ofrecer pautas para el manejo de esta entidad. Metodología de búsqueda: se realizó una búsqueda bibliográfica en las bases de datos Pubmed, LILACS, SciELO y el motor de búsqueda Google Scholar, de artículos publicados hasta agosto de 2017, utilizando los términos hepatitis B virus AND infection AND pregnancy. Se restringió la búsqueda a artículos de los últimos quince años, en inglés y español, incluyendo artículos de revisión, estudios clínicos controlados y metaanálisis. Se obtuvieron en total 535 manuscritos para revisión, de los cuales 52 fueron referenciados. Desarrollo del tema: los hijos de madres seropositivas para el antígeno de superficie de la hepatitis B deberían recibir inmunoglobulina y vacunación contra la hepatitis B en las primeras doce horas de nacimiento, lográndose reducir la tasa de transmisión vertical desde más del 90% a menos del 10%. La terapia antiviral, al ser administrada en el tercer trimestre de gestación, puede prevenir la falla inmunoprofiláctica, y debería utilizarse en madres con alto riesgo de trasmisión vertical. Datos recientes apuntan acerca de la seguridad de Tenofovir en el embarazo, siendo actualmente el medicamento de elección. Conclusiones: el tamizaje universal en la gestante para la infección por el virus de la hepatitis B es una medida costoefectiva para reducir la transmisión vertical. Los niveles elevados de antígeno de superficie del virus de la hepatitis B y la carga viral materna, así como la presencia de antígeno e, se asocian a mayor riesgo de transmisión vertical. La combinación de inmunoglobulina y vacunación para hepatitis B, administradas dentro de las doce horas posteriores al nacimiento, se asocian a reducción de la tasa de transmisión vertical. El Tenofovir es la mejor opción terapéutica como terapia antiviral iniciado en las semanas 28-32 de gestación en aquellas gestantes con alto riesgo de transmisión de la infección. MÉD.UIS. 2018;31(2):49-56.
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Bang, Nguyen N., Nguyen V. Chanh, Nguyen X. Trach, Duong N. Khang, Ben J. Hayes, John B. Gaughan, Russell E. Lyons, Nguyen T. Hai und David M. McNeill. „Assessment of Performance and Some Welfare Indicators of Cows in Vietnamese Smallholder Dairy Farms“. Animals 11, Nr. 3 (03.03.2021): 674. http://dx.doi.org/10.3390/ani11030674.
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Smallholder dairy farms (SDFs) are distributed widely across lowland and highland regions in Vietnam, but data on the productivity and welfare status of these cows remains limited. This cross-sectional study was conducted to describe and compare the productivity and welfare status of SDF cows across contrasting regions. It was conducted in autumn 2017 on 32 SDFs randomly selected from four typical but contrasting dairy regions (eight SDFs per region); a south lowland, a south highland, a north lowland, and a north highland region. Each farm was visited over a 24-h period (an afternoon followed by a morning milking and adjacent husbandry activities) to collect data of individual lactating cows (n = 345) and dry cows (n = 123), which included: milk yield and concentrations, body weight (BW), body condition score (BCS, 5-point scale, 5 = very fat), inseminations per conception, and level of heat stress experienced (panting score, 4.5-point scale, 0 = no stress). The high level of heat stress (96% of lactating cows were moderate to highly heat-stressed in the afternoon), low energy corrected milk yield (15.7 kg/cow/d), low percentage of lactating cows (37.3% herd), low BW (498 and 521 kg in lactating and dry cows, respectively), and low BCS of lactating cows (2.8) were the most important productivity and welfare concerns determined and these were most serious in the south lowland. By contrast, cows in the north lowland, a relatively hot but new dairying region, performed similarly to those in the south highland; a region historically considered to be one of the most suitable for dairy cows in Vietnam due to its cool environment. This indicates the potential to mitigate heat stress through new husbandry strategies. Cows in the north highland had the highest BW (535 and 569 kg in lactating and dry cows, respectively) and the highest energy corrected milk yield (19.2 kg/cow/d). Cows in all regions were heat-stressed during the daytime, although less so in the highlands compared to the lowlands. Opportunities for research into improving the productivity and welfare of Vietnamese SDF cows are discussed.
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Xi, Xinming, Zicheng Zhang, Huimin Wei, Zeyu Chen und Xiaoze Du. „Experimental Study of Simultaneous Charging and Discharging Process in Thermocline Phase Change Heat Storage System Based on Solar Energy“. Sustainability 15, Nr. 9 (28.04.2023): 7322. http://dx.doi.org/10.3390/su15097322.
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As a renewable energy power generation method, concentrating solar power generation has a broad application prospect. Weather and fluctuation significantly affect the output power of concentrating solar power generation. A heat storage system can stabilize this fluctuation and generate continuous and stable power. Therefore, the research on heat storage systems is of great significance to the development of concentrating solar power generation. This paper mainly studies the operating characteristics of the heat storage system based on solar energy in simultaneous charging, the influence in the change in solar radiation intensity on the charging power and the discharging outlet temperature, and the feasibility of the heat storage tank as an inertial link to stabilize the fluctuation in solar energy and the discharging outlet temperature. In this study, an experimental system for heat storage was established, in which solar energy was used as the heat source, water was used as the heat transfer fluid, and paraffin was used as the phase change heat storage material. When the initial temperature is 50 °C and the charging flow rate is maintained at 0.7 m3/h, at the same time the discharging flow rate is 0.1 m3/h, 0.3 m3/h, and 0.5 m3/h, respectively. The results show that when the solar radiation intensity is lower than 548 W/m2, the curve of heat storage power is almost parallel to the curve of solar radiation intensity; when the solar radiation intensity is lower than 535 W/m2, the moving direction of the thermocline will change; the average discharging outlet temperature in each case is higher than the phase change temperature of the phase change material and this system can continuously supply hot water at more than 69 °C for more than 3 h 32 min; and increasing the discharging flow rate will increase the whole charging and discharging time, thicken the thermocline, and disturb the temperature field in the tank. The experimental analysis will be conducive to profoundly understanding the operation characteristics of the thermocline heat storage tank under the solar heat source and has reference value for the subsequent design of a more efficient heat storage system.
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Leva, Charles Di. „Emerging Principles of International Environmental Law. By Sumudu Atapattu. Transnational Publishers, 2006. Pp. xxviii, 535. Index. $125, €125. - International Environmental Law: Fairness, Effectiveness and World Order. By Elli Louka. Cambridge University Press, 2006. Pp. xvi, 518. Index. $101, £59, cloth; $52, £32, paper.“ American Journal of International Law 101, Nr. 4 (Oktober 2007): 933–38. http://dx.doi.org/10.1017/s0002930000037842.
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Renouf, D., R. Wood-Baker, D. Ionescu, S. Leung, H. Massoudi, B. Gilks und J. Laskin. „Prognostic significance of immunohistochemical markers in non-small cell lung cancer“. Journal of Clinical Oncology 24, Nr. 18_suppl (20.06.2006): 7211. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.7211.
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7211 Background: The purpose of this study is to use a large patient population to identify immunohistochemical (IHC) biomarkers to enable improved prognostication in patients with non-small cell lung cancer (NSCLC). Methods: A tissue microarray was constructed using duplicate 0.6 mm cores of formalin-fixed paraffin embedded tissue blocks from 609 patients with NSCLC. IHC was used to detect 11 biomarkers including EGFR, HER2, HER3, p53, p63, Bcl-1, Bcl-2, TTF-1, CEA, Ch, and SNP. A clinical database was created prospectively at the time of tissue collection. Survival outcomes were obtained from a Provincial Cancer Registry database. Results: Male to female ratio was 400:209; median age 63yrs (range 35–82); median survival 3.5yrs (mean 5.7). All specimens were reviewed: 243 adenocarcinoma (ACA), 272 squamous cell carcinoma (SCC), 35 large cell carcinoma, 32 non-small cell carcinoma NOS, and 6 other (giant cell carcinoma). 21 patients with other histologies were excluded. Survival data for 535 cases was available. As of June 2005, 429 patients (80%) had died; of these 286 (54%) died of lung cancer, 117 (22%) died of other known causes, and for 26 (5%) the cause of death was not available. Bcl-2 (p = 0.007) was the only biomarker to predict better overall survival (OS). Bcl-2 (p = 0.021) and p63 (p = 0.025) were significant for disease specific survival (DSS) in all NSCLC. Analysis of the subgroups indicated that p63 was significant (p = 0.039) for DSS in squamous cell carcinoma (SCC) but not for adenocarcinoma (ACA) (p = 0.81). Bcl-2 was not significant for DSS in either subgroup (p = 0.28 for SCC, p = 0.112 for ACA). EGFR expression was associated with improved DSS in SCC (p = 0.012) but not for ACA. Co-expression of EGFR-HER3 was more likely in SCC then in ACA (p = 0.033). There was no correlation between outcome and any combination or clustering of biomarkers. Conclusions: The biomarkers p63 and Bcl-2 are predictive of DSS in NSCLC. EGFR expression is predictive of DSS in SCC. Sub-classification of NSCLC by histopathology is important as the relevance of some biomarkers (EGFR) would be lost if pooled. p63, Bcl-2, and EGFR may be used as prognostic markers in patients with NSCLC. Co-expression of EGFR-HER3 is more likely in SCC then in ACA. This may help explain the differential response to EGFR inhibitors in SCC versus ACA. No significant financial relationships to disclose.
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Tsai, Kuochen, Paul A. Gillis, Subrata Sen und Rodney O. Fox. „A Finite-Mode PDF Model for Turbulent Reacting Flows“. Journal of Fluids Engineering 124, Nr. 1 (25.04.2001): 102–7. http://dx.doi.org/10.1115/1.1431546.
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The recently proposed multi-environment model, R. O. Fox, 1998, “On the Relationship between Lagrangian Micromixing Models and Computational Fluid Dynamics,” Chem. Eng. Proc., Vol. 37, pp. 521–535. J. Villermaux and J. C. Devillon, 1994, “A Generalized Mixing Model for Initial Contacting of Reactive Fluids,” Chem. Eng. Sci., Vol. 49, p. 5127, provides a new category of modeling techniques that can be employed to resolve the turbulence-chemistry interactions found in reactive flows. By solving the Eulerian transport equations for volume fractions and chemical species simultaneously, the local concentrations of chemical species in each environment can be obtained. Assuming micromixing occurs only in phase space, the well-known IEM (interaction by exchange with the mean) model can be applied to close the micromixing term. This simplification allows the model to use micromixing timescales obtained from more sophisticated models and can be applied to any number of environments. Although the PDF shape doesn’t change under this assumption, the interaction between turbulence and chemistry can be resolved up to the second moments without any ad-hoc assumptions for the mean reaction rates. Furthermore, the PDF shape is found to have minimal effect on mean reaction rates for incompressible turbulent reacting flows. In this formulation, a spurious dissipation term arises in the transport equation of the scalar variances due to the use of Eulerian transport equations. A procedure is proposed to eliminate this spurious term. The model is applied to simulate the experiment of S. Komori, et al., 1993, “Measurements of Mass Flux in a Turbulent Liquid Flow With a Chemical Reaction,” AIChE J., Vol. 39, pp. 1611–1620, for a reactive mixing layer and the experiment of K. Li and H. Toor, 1986, “Turbulent Reactive Mixing With a Series Parallel reaction: Effect of Mixing on Yield,” AIChE J., Vol. 32, pp. 1312–1320, with a two-step parallel/consecutive reaction. The results are found to be in good agreement with the experimental data of Komori et al. and the PDF simulation of K. Tsai and R. Fox, 1994, “PDF Simulation of a Turbulent Series-Parallel Reaction in an Axisymmetric Reactor,” Chem. Eng. Sci., Vol. 49, pp. 5141–5158, for the experiment of Li and Toor. The resulting model is implemented in the commercial CFD code, FLUENT,1 and can be applied with any number of species and reactions.
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Braia, V., R. Manai, P. Bocchino, F. Angelini, G. Gallone, G. De Lio, S. Pidello et al. „REAL WORLD USAGE OF RANOLAZINE FOR ANTIARRHYTHMIC PURPOSES: SINGLE CENTER EXPERIENCE“. European Heart Journal Supplements 26, Supplement_2 (April 2024): ii47. http://dx.doi.org/10.1093/eurheartjsupp/suae036.105.
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Abstract Introduction Ranolazine is a late sodium current blocking drug developed as an antianginal agent, with good preliminary efficacy data even for antiarrhythmic purposes (both at atrial and at ventricular level). Objectives To evaluate patients’ clinical characteristics and antiarrhythmic efficacy of ranolazine in subjects with a history of atrial and/or ventricular arrhythmias, isolated or repetitive. Patients and methods we included patients who received a first prescription of ranolazine for antiarrhythmic purposes in our center from 1/2022 to 11/2023 and evaluated the survival free from major arrhythmic relapses/ablation. Results 93 patients were enrolled (66±13 years, 15% women): 59% with arterial hypertension, 26% diabetics, 46% with post–ischemic dilated heart disease, 32% with primary cardiomyopathy (including 11% with hypertrophic cardiomyopathy, 10% with LMNA, 14% with TTN), 46% with implantable cardioverter defibrillator, 9% with pacemaker. The mean LV ejection fraction was 42 ± 15%, the mean serum creatinine 1 ± 0.3 mg/dL. Half (50%) had a history of atrial arrhythmias in the 6 months before starting the drug, mainly paroxysmal atrial fibrillation (AF), 67% of ventricular arrhythmias (VAs), mainly isolated and repetitive premature ventricular beats (PVB, 47% of the total), but also sustained or treated VAs (n=18, 19%). Overall, 18% of patients had already undergone AF ablation, 13% ventricular tachycardia ablation, 3% cardiac sympathetic denervation. Finally, 95% of patients were on beta–blocker therapy and 28% were on amiodarone. Ranolazine was prescribed at an average initial dose of 535± 150 mg. The majority (54%) of patients (n=50) had a follow–up longer than 3 months (median 9 months, IQR 6–14); in 6% the drug was stopped due to intolerance and the average dose at the last FU was 641 ± 150 mg. Twenty–eight percent of patients with paroxysmal/persistent atrial arrhythmias had relapses, requiring ablation in 6%. Among patients with major VAs, 57% suffered recurrences, but only 19% required ablation (invasive in 2 cases, non–invasive in 1 case). Finally, among the patients with PVBs, none suffered major VAs or required PVB/VA ablation. Conclusions This is the largest available case–series reporting about the real–world usage of ranolazine for antiarrhythmic purposes. Our single center experience supports ranolazine’s good safety and tolerability and shows encouraging efficacy results in terms of clinical stabilization of complex patients.
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Piovella, Franco, Andrea M. D’Armini, Marisa Barone, Vincenzo Emmi, Chiara Beltrametti und Mario Viganò. „Long Term Results of Pulmonary Endarterectomy (PEA) in Patients with Chronic Thromboembolic Pulmonary Hypertension (CTEPH). The Pavia Endarterectomy Program.“ Blood 110, Nr. 11 (16.11.2007): 4006. http://dx.doi.org/10.1182/blood.v110.11.4006.4006.
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Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare disease which results from obstruction of the major pulmonary arteries by incompletely resolved or organized pulmonary emboli which have become incorporated into the pulmonary artery wall, eventually causing an increase in pulmonary vascular resistances. Pulmonary endarterectomy (PEA) is the treatment of choice. Careful pre- and post-operative management is essential for a successful outcome following PEA. In 1994, we started in Pavia a program in which members of a multidisciplinary team work in close interaction with the aim of increase experience in the challenging problems these patients present in the evaluative, surgical, and post-operative phases of their care. So far, 134 PEAs have been performed. Preoperatively, New York Heart Association (NYHA) class distribution was respectively 3-II, 56-III, and 75-IV; mean pulmonary artery pressure and pulmonary vascular resistances were 47 ± 13 mmHg and 1149 ± 535 dynes/sec/cm−5 respectively. The overall operative mortality has been 9.7% (in 2005 mortality rate was 4.5%). At present, 92% of the PEA patients are actively participating in the follow-up study. Follow-up visits are at 3 months after PEA, yearly for the following 5 years, and then at 7, 10, and 15 years postoperatively. Both early and late survivals were excellent. Survival rate at 3 months, 1 year, and 3 years were respectively of 89.5±2.7%, 87.3±3.0%, and 82.7±3.6%. Survival rates had not changed at 5, 7, and 10 years postoperative. Three months after PEA, 29 (58%) subjects were within NYHA class I, 18 (36%) in class II, and 3 (6%) in class III. At 1-year follow-up, 40 (80%) patients were within NYHA class I, 10 (20%) in class II. A statistically significant difference exists not only between the preoperative and the postoperative data (p <0.0001), but also between the functional status at 3 months and the other two postoperative controls (p <0.001). Table summarizes the results of hemodynamic tests collected at three months, one year and three years on the first 35 patients who completed the follow-up program. Hemodynamic data from 35 patients participating to the Pavia Pulmonary Endarterectomy Program with complete 3-year follow-up. CVP mPAP CO CI PVR PVRI CVP (mmHg) central venous pressure; mPAP (mmHg) mean pulmonary artery pressure; CO (L/min) cardiac output; CI (L/min/m2) cardiac index; PVR (dynes/sec/cm-5) pulmonary vascular resistances; PVRI (dynes/sec/cm-5/m2) pulmonary vascular resistances index; RV-EF (%) right ventricle ejection fraction. RV-EF A: Before-PEA 7±6 48±12 3.3±0.9 1.8±0.5 1125±412 2027±731 15±8 B:Before discharge 5±4 25±10 5.2±1.1 2.9±0.5 289±142 505±234 32±8 C: 3 months 2±2 24±11 5.1±1.4 2.8±0.6 231±198 542±271 32±7 D: 1 year 1±2 23±12 5.0±1.1 2.7±0.6 290±191 531±343 35±8 E: 3 years 2±2 24±12 4.9±1.1 2.6±0.5 317±226 579±393 34±8 p value A vs. B: nsA vs. C, D, and E: <0.0001B vs. C, D and E: <0.05 A vs. B, C, D and E: <0.0001 A vs. B, C, D and E: <0.0001 A vs. B, C, D and E: <0.0001 A vs. B, C, D and E: <0.0001 A vs. B, C, D and E: <0.0001 A vs. B, C, D and E:
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Uspenskiy, Y., M. Galagudza, S. Ivanov, Y. Fominikh, R. Dreval und O. Mayorova. „P652 Treatment patterns in patients receiving outpatient care for inflammatory bowel disease in Russian Federation“. Journal of Crohn's and Colitis 15, Supplement_1 (01.05.2021): S582—S583. http://dx.doi.org/10.1093/ecco-jcc/jjab076.772.
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Abstract Background There is a global trend of increasing prevalence of inflammatory bowel disease (IBD) worldwide, Russian Federation including. Meanwhile, treatment options for patients with IBD have expanded significantly in recent years with the advent of novel biotherapeutics. However, insufficient information is available on the treatment patterns of Crohn’s disease (CD) and ulcerative colitis (UC) in large cities. We aimed to study the levels of usage of different therapeutic agents in the patients with IBD receiving outpatient care in St-Petersburg, Russian Federation. Methods In a cross-sectional study lasting from January 1, 2019 to December 31, 2019, the data on drug therapy of adult (> 18 years old) patients with IBD were obtained from 42 outpatient clinics of St. Petersburg. The Wilson’s method of 95% confidence interval (CI) determination was used to determine the statistical differences in the levels of usage of different therapeutics. р values ≤ 0.05 were considered significant. The data on continuous variables are presented as “median (25 quartile; 75 quartile)”. Results In total, 535 patients were included. Among them, there were 241 and 294 patients with CD and UC, respectively. Mean age of the patients with CD and UC was 40 (29; 59) and 43 (32; 59) years, respectively (p > 0.05). Among the patients with CD, the ileal, colonic, ileocolonic, and other locations were found in 23.4, 37.6, 34.4, and 4.6 %, respectively. In UC patients, we observed proctitis, left-sided colitis and pancolitis in 24.4, 55.2, and 20.4%, respectively. Oral 5-aminosalicylic acid (5-ASA) drugs, topical 5-ASA drugs, oral (both systemic and topical) glucocorticoids, immunosuppressants, and biologicals were used in 89.3 (84.4–92.8), 32.6 (26.7–39.1), 17.5 (13.0–23.1), 16.5 (12.2–22.0), and 7.3% (0.4–11.7) of patients with CD, accordingly. In UC patients, oral 5-ASA, topical 5-ASA, oral (both systemic and topical) glucocorticoids, immunosuppressants, and biologicals were used in 86.2 (81.4–90.0), 63.1 (56.9–68.8), 12.1 (8.6–16.8), 4.4 (2.5–7.7), and 0.8% (0.02–2.7) of cases, accordingly. Conclusion Oral 5-ASA is the most commonly used class of drugs in Russian patients with both CD and UC. The use of topical 5-ASA formulations was more common in patients with UC as compared to CD patients, while immunosuppressive drugs were more commonly prescribed to CD vs. UC patients. We found relatively rare use of systemic and topical oral glucocorticoids in the patients with IBD receiving outpatient care. In our cohort, the use of biological agents was minimal, which probably reflects the trend of prescribing biologicals mostly at the specialized clinics.
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Roy, Udoy Shankar, Md Murshidur Rahman Khan, Tapas Kanti Bhowmik und Ramendra Nath Sarker. „Value of the Resting Electrocardiogram in Assessing Patients with Recent Onset Chest Pain A Study in Tertiary Care Hospital, Dhaka Bangladesh“. Journal of Shaheed Suhrawardy Medical College 9, Nr. 2 (05.07.2018): 65–68. http://dx.doi.org/10.3329/jssmc.v9i2.37265.
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Background: Chest pain or discomfort caused by acute coronary syndrome (ACS) or angina has a potentially poor prognosis, emphasizing the importance of prompt and accurate diagnosis. To evaluate a clinic set up specifically to assess patients with recent onset chest pain, particularly those presenting with a normal resting electrocargram.Method: The cross-sectional study was carried out from September 2016 to August 2017 in cardiology department of Shaheed Suhrawardy Medical College hospital, Sher-E-Bangla Nagar, Dhaka. Total 1000 consecutive patients with recent onset chest pain were evaluated within 24 hours of general practitioner referral, to find out the clinical diagnosis and management.Results: Total 1000 patients (535 men and 465women, mean age 51.5±11.4 years with range from 32 to 70 years) were assessed over 12 months. Most of the patients 844 (84.4%) had symptoms in duration of ≤30 days. Majority 433 (43.3%) patients had peptic ulcer disease (PUD), 317 (31.7%) patients had chronic stable angina (CSA), 94 (9.4%) had unstable angina (UA), 92 (9.2%) had anxiety neurosis (AN) and 64 (6.4%) had myocardial infarction (MI). Regarding outcome of the patients 525 (52.5%) [PUD: 433+ AN: 91] patients considered to have noncardiac pain and referred to medicine outpatient department (OPD) without further follow up. In a further 317 patients (31.7%, CSA) arrangements were made for outpatient review. Ninety four patients (9.4%, UA) were referred to National Institute of Cardiovascular diseases (NICVD) for admission out of them 61 patients were admitted for medical treatment & 33 patients were discharged from emergency department whose troponin-I were negative. Remaining 64 (6.4%) acute MI patients were admitted into Coronary Care Unit (CCU) of NICVD, out of them 41 patients received streptokinase injection, 23 patients received Enoxaparin injection, after conservative treatment all patients were advised to do coronary angiography within 3 to 4 weeks. Among these 43 patients underwent coronary angiography within 4 weeks, 23 patients had coronary angioplasty, eleven patients had coronary bypass surgery and nine patients refused any intervention and discharged with medicine.Conclusion: This experience highlights the inadequacy of a routine electrocardiogram reporting service in patients with recent onset of chest pain. Clinical diagnosis found were peptic ulcer disease (PUD), chronic stable angina (CSA), unstable angina (UA), anxiety neurosis and myocardial infarction (MI). Regarding outcome of the patients were coronary angiography followed by coronary angioplasty, coronary artery bypass surgery, discharged with medicine and referred to out patients department of medicine unit.J Shaheed Suhrawardy Med Coll, December 2017, Vol.9(2); 65-68