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Ziani, F., S. A. Brahmi, L. Amaadour, B. Meryem, K. Rajae, Z. L. Fatima, A. Samia und M. Nawfel. „P-082 Gastric cancer in Moroccan patients aged 45 years or younger: Clinicopathological features and prognosis“. Annals of Oncology 26 (Juni 2015): iv23. http://dx.doi.org/10.1093/annonc/mdv233.82.
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ADENEKAN, SHOLA. „CHANTAL ZABUS, Out in Africa: same-sex desire in sub-Saharan literatures & cultures. Woodbridge: James Currey (hb £45 – 978 1 84701 082 7). 2013, 292 pp.“ Africa 85, Nr. 3 (09.07.2015): 552–54. http://dx.doi.org/10.1017/s0001972015000406.
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Oliver, Jonathan M., Dustin P. Joubert, Steven E. Martin und Stephen F. Crouse. „Oral Creatine Supplementation’s Decrease of Blood Lactate During Exhaustive, Incremental Cycling“. International Journal of Sport Nutrition and Exercise Metabolism 23, Nr. 3 (Juni 2013): 252–58. http://dx.doi.org/10.1123/ijsnem.23.3.252.
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Purpose:To determine the effects of creatine supplementation on blood lactate during incremental cycling exercise.Methods:Thirteen male subjects (M ± SD 23 ± 2 yr, 178.0 ± 8.1 cm, 86.3 ± 16.0 kg, 24% ± 9% body fat) performed a maximal, incremental cycling test to exhaustion before (Pre) and after (Post) 6 d of creatine supplementation (4 doses/d of 5 g creatine + 15 g glucose). Blood lactate was measured at the end of each exercise stage during the protocol, and the lactate threshold was determined as the stage before achieving 4 mmol/L. Lactate concentrations during the incremental test were analyzed using a 2 (condition) × 6 (exercise stage) repeated-measures ANOVA. Differences in power at lactate threshold, power at exhaustion, and total exercise time were determined by paired t tests and are presented as M ± SD.Results:Lactate concentrations were reduced during exercise after supplementation, demonstrating a significant condition effect (p = .041). There was a tendency for increased power at the lactate threshold (Pre 128 ± 45 W, Post 143 ± 26 W; p = .11). Total time to fatigue approached significant increases (Pre 22.6 ± 3.2 min, Post 23.3 ± 3.3 min; p = .056), as did maximal power output (Pre 212.5 ± 32.5 W, Post 220 ± 34.6 W; p = .082).Conclusions:Our findings demonstrate that creatine supplementation decreases lactate during incremental cycling exercise and tends to raise lactate threshold. Therefore, creatine supplementation could potentially benefit endurance athletes.
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Xiao, Yu-Tian, Xianzhi Zhao, Yifan Chang, Xiaojun Lu, Ye Wang, Huojun Zhang und Shancheng Ren. „Assessing the safety and feasibility of neoadjuvant hormone and radiation therapy followed by robot-assisted radical prostatectomy for treating locally advanced prostate cancer: protocol for an open-label, dose-escalation, single-centre, phase I clinical trial“. BMJ Open 10, Nr. 11 (November 2020): e038678. http://dx.doi.org/10.1136/bmjopen-2020-038678.
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IntroductionPatients with locally advanced prostate cancer are at high risk of recurrence after definitive treatment. There are emerging data that radical prostatectomy can delay the progression of castration resistance and potentially prolong survival. Neoadjuvant radiation therapy improves local control and has shown survival benefit with favourable toxicity profiles in several other malignancies. We have designed this trial to investigate whether this combination, which theoretically maximises local control, is a safe and feasible approach for treating locally advanced prostate cancer.Methods and analysisThis study is a phase I, open-label study to investigate the safety and feasibility of neoadjuvant hormone and radiation therapy followed by robot-assisted radical prostatectomy by a traditional 3+3 dose-escalation design with four planned radiation dose levels (39.6 Gy/22F, 45 Gy/25F, 50.4 Gy/28F and 54 Gy/30F). Locally advanced prostate cancer patients with positive pelvic and/or retroperitoneal lymph nodes will be recruited. The primary objective is to determine the adverse events and maximal tolerable dose (MTD) of neoadjuvant radiotherapy. Toxicity will be assessed using the National Cancer Institute Common Toxicity Criteria V.5.0.Ethics and disseminationThis protocol was approved by the Institutional Review Board of Shanghai Changhai Hospital (ref. CHEC2019-070 and CHEC2019-082). The study will be performed in compliance with applicable local legislation and in accordance with the ethical principles developed by the World Medical Association in the Declaration of Helsinki 2013. Study results will be disseminated through conferences and peer-reviewed scientific journals.Trial registration numbersChiCTR1900022716; ChiCTR1900022754.
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Yvernault, Martine. „William Perry MARVIN, Hunting Law and Ritual in Medieval English Literature , Woodbridge, Brewer, 2006 ; 1 vol., X-198 p. ISBN : 1-84434-082-0. Prix : GBP 45 ; USD 80.“ Le Moyen Age Tome CXIV, Nr. 3 (23.02.2009): LXVIII. http://dx.doi.org/10.3917/rma.143.0647zzp.
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Benndorf, J. „RAINER STAWIKOWSKI und UWE WERNER: Die Buntbarsche der Neuen Welt — Südamerika.— 288 S., 176 Farb- und 105 Schwarzweißphotos. Stuttgart: Verlag Eugen Ulmer 1988. ISBN 3–87401–082–1. DM 45,—“. Internationale Revue der gesamten Hydrobiologie und Hydrographie 75, Nr. 5 (1990): 694. http://dx.doi.org/10.1002/iroh.19900750531.
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Elías, Rudy. „International programs for the evaluation of academic achievements and their influence on educational policies in Latin America“. Población y Desarrollo 23, Nr. 45 (30.12.2017): 74–82. http://dx.doi.org/10.18004/pdfce/2076-054x/2017.023(45)074-082.
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Ikuta, Keiko, Shunsaku Nakagawa, Kenji Momo, Atsushi Yonezawa, Kotaro Itohara, Yuki Sato, Satoshi Imai, Takayuki Nakagawa und Kazuo Matsubara. „Association of proton pump inhibitors and concomitant drugs with risk of acute kidney injury: a nested case–control study“. BMJ Open 11, Nr. 2 (Februar 2021): e041543. http://dx.doi.org/10.1136/bmjopen-2020-041543.
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ObjectivesThis study aimed to assess whether the combined use of proton pump inhibitors (PPIs) with non-steroidal anti-inflammatory drugs (NSAIDs) or antibiotics (penicillins, macrolides, cephalosporins or fluoroquinolones) was associated with an increased risk of acute kidney injury (AKI).DesignA nested case–control study.SettingA health insurance claims database constructed by the Japan Medical Data Center.ParticipantsPatients were eligible if they were prescribed a PPI, NSAID and antibiotic at least once between January 2005 and June 2017. The patients who were new PPI users and did not have any history of renal diseases before cohort entry were included (n=219 082). The mean age was 45 and 44% were women.InterventionsCurrent use of PPIs, NSAIDs, or antibiotics.Primary outcome measuresAcute kidney injury.ResultsDuring a mean follow-up of 2.4 (SD, 1.7) years, 317 cases of AKI were identified (incidence rate of 6.1/10 000 person-years). The current use of PPIs was associated with a higher risk of AKI compared with past PPI use (unadjusted OR, 4.09; 95% CI, 3.09 to 5.44). The unadjusted ORs of AKI for the current use of PPIs with NSAIDs, cephalosporins and fluoroquinolones, compared with the current use of PPIs alone, were 3.92 (95% CI, 2.40 to 6.52), 2.57 (1.43 to 4.62) and 3.08 (1.50 to 6.38), respectively. The effects of concurrent use of PPIs with NSAIDs, cephalosporins or fluoroquinolones remain significant in the adjusted model. The analyses on absolute risk of AKI confirmed the results from the nested case–control study.ConclusionsConcomitant use of NSAIDs with PPIs significantly increased the risk for AKI. Moreover, the results suggested that concomitant use of cephalosporins or fluoroquinolones with PPIs was associated with increased risk of incident AKI.
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Aung, Si Thu, Wint Wint Nyunt, Myat Myat Moe, Htin Lin Aung und Thandar Lwin. „The fourth national tuberculosis prevalence survey in Myanmar“. PLOS Global Public Health 2, Nr. 6 (14.06.2022): e0000588. http://dx.doi.org/10.1371/journal.pgph.0000588.
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Tuberculosis (TB) remains a significant cause of morbidity and mortality in Myanmar. The fourth National TB Prevalence Survey was conducted in 2017–2018 to determine the actual burden of TB not only at the national level but also for three subnational strata (the states, regions other than Yangon, and the Yangon region) and develop a more efficacious country strategy on TB care and control. One hundred and thirty eight clusters were selected by population proportionate sampling. Adult (≥15 years of age) residents having lived for 2 weeks or more in the households of the selected clusters were invited to participate in the survey. The survey participants were screened for TB by a questionnaire and digital chest X-ray (CXR) after providing written informed consent. Individuals with a positive symptom screen and/or chest X-ray suggestive of TB were asked to provide sputum samples to test for Mycobacterium tuberculosis (Mtb) by Ziehl-Neelsen direct light microscopy, Xpert MTB/RIF Ultra (Xpert), and culture (Ogawa media). Bacteriologically confirmed TB cases were defined by an expert panel. Of 75 676 eligible residents, 66 480 (88%) participated, and 10 082 (15%) screened positive for TB. Among these, 322 participants were defined as bacteriologically confirmed TB cases. Cough lasting for two weeks or longer, one of the criteria used for screening for symptoms, could detect only 14% (45/322) of the study cases. The estimated prevalence of bacteriologically confirmed adult pulmonary TB was 468 (95% CI: 391–546) per 100,000. The prevalence was much higher among males, the older age group, urban Yangon and remote villages. In-depth interview with the participants on TB treatment showed that none of them was diagnosed in a TB health centre (primary care facilities). The prevalence of TB in Myanmar is still high due to challenges such as uncontrolled urbanization, an ageing population, migration, and poor access to health facilities in remote areas. New screening and diagnostic tools might help to detect more TB patients. There is a need to lay greater emphasis on multisectoral approaches, decentralization and the integration of basic TB services into primary care facilities.
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Moccia, Moccia A., Jane Donaldson, Mukesh Chhanabhai, Paul Hoskins, Richard Klasa, Kerry J. Savage, Tamara Shenkier et al. „The International Prognostic Factor Project Score (IPS) in Advanced Stage Hodgkin Lymphoma Has Limited Utility in Patients Treated in the Modern Era.“ Blood 114, Nr. 22 (20.11.2009): 1554. http://dx.doi.org/10.1182/blood.v114.22.1554.1554.
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Abstract Abstract 1554 Poster Board I-577 Introduction The International Prognostic Factor Project Score (IPS) is the most widely utilized risk stratification index for Hodgkin lymphoma (HL) (Hasenclever, N Engl J Med, 1998). Based on patients treated before 1992, it incorporates 7 adverse risk features (male gender, age ≥45 y, stage IV, hemoglobin <105 g/L, WBC ≥15 × 109/L, lymphocyte count <0.6 × 109/L or <8% of differential, albumin <40 g/L) and predicts for a 5-year freedom-from progression (FFP) ranging from 42-84%.The IPS has not been validated in a more recently treated population, where more accurate pathologic diagnosis, routine use of growth factors and enhanced supportive care may have improved outcomes compared with historic results. Methods This retrospective population-based analysis used the British Columbia Cancer Agency Lymphoid Cancer Database to identify all patients ages 15-65 y diagnosed from January 1st,1990 to June 30th, 2008 with advanced stage HL (stage III/IV, or stage I/II with B symptoms or bulky disease ≥10 cm), who were treated with curative intent with ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) or an ABVD-equivalent regimen and had complete information including all IPS variables. Primary endpoint was FFP, defined as the interval from diagnosis to first progression or relapse or death due to treatment toxicity; deaths from unrelated causes were censored. Results 579 patients were identified. Median age was 29 y (range 15-65); 11 (2%) stage I, 239 (41%) stage II, 202 (35%) stage III and 127 (22%) stage IV; 245 (42.3%) had bulky disease; and 359 (62%) had B symptoms. Histologies included: 455 (79%) nodular sclerosing, 35 (6%) mixed cellularity, 7 (1%) lymphocyte-rich, 11 (2%) lymphocyte depleted, 13 (2%) nodular lymphocyte predominant, 58 (10%) HL NOS. 161 (28%) patients received IFRT with primary treatment. Adverse prognostic factors were present as follows: 119 (21%) age≥45, 375 (65%) albumin <40 g/L, 88 (15%) WBC ≥15 × 109/L, 116 (20%) hemoglobin <105 g/L, 57 (10%) lymphocyte count <0.6 × 109/L or <8%, 302 (52%) male, 127(22%) stage IV. Only 37 (6.4%) patients had a prognostic score ≥5. With a median follow-up of 73 months (range, 1-222), 512 (88.4%) patients were alive and 67 (11.6%) had died (39 with HL, 7 due to toxicity and 21 from unrelated causes). Five year FFP and overall survival (OS) were 79% and 91%, respectively. The IPS was prognostic for both FFP (p=.0035) and OS (p<.0001), with 5-y FFP ranging from 66% to 86% and 5-y OS ranging from 74% to 98% (Table 1). In univariate analysis only stage IV (p=.003) and hemoglobin (P=.001) were prognostic for FFP. Albumin (p=.054), age (p=.082) and WBC (p=.094) were borderline significant, but gender (p=.329) and lymphocyte count (P=.496) appeared to have a weaker prognostic value for FFP. Only stage IV (HR=1.63, CI 1.10-2.40, p=.014) and hemoglobin (HR=1.73, CI 1.17-2.57, p=.006) were prognostic for FFP in a multivariate Cox regression. Conclusion The IPS remains prognostic for patients with advanced stage HL treated in a more modern era. However, it does not identify risk groups with sufficiently good or poor outcome to justify deviation from standard therapy. Identification of truly low or high risk populations will require supplementation with molecular markers and/or the use of early PET scanning. Caution should be used when comparing results from current clinical trials to historic controls, since more recent outcomes with standard therapy are clearly superior to those previously reported. Disclosures No relevant conflicts of interest to declare.
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BLACK, J. M. W., F. A. BARAGAR und D. S. CHANASYK. „A MATHEMATICAL MODEL TO ESTIMATE AGGREGATE BREAKDOWN DURING SOIL SIEVING IN A MODIFIED RAPD3 ROTARY SIEVE“. Canadian Journal of Soil Science 69, Nr. 4 (01.11.1989): 817–24. http://dx.doi.org/10.4141/cjss89-082.
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The percentage of soil material > 0.84 mm obtained by dry sieving is commonly used as an index of the wind erodibility of soils. Present sieving procedures do not account for the breakdown of friable aggregates during sieving so that results do not necessarily represent aggregation in the original sample. An equation was fitted to soil sieving data from a modified rapid rotary sieve. It successfully evaluated aggregate attrition during sieving for 397 out of 404 samples representing a wide variety of textures. Good reproducibility of results using the methodology was obtained for 45 paired soil samples. Results obtained employing the new method will relate more closely to field conditions allowing a better estimate of soil erodibility. Key words: Wind erosion, aggregate breakdown, sieving, soil erodibility, modified rapid rotary sieve
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Kawahara, Naoko, Hisayoshi Ikatsu, Hiroshige Kawata, Shin-ichi Miyoshi, Ken-ichi Tomochika und Sumio Sinoda. „Purification and characterization of 2-ethoxyphenol-induced cytochrome P450 fromCorynebacteriumsp. strain EP1“. Canadian Journal of Microbiology 45, Nr. 10 (01.10.1999): 833–39. http://dx.doi.org/10.1139/w99-082.
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A soluble cytochrome P450 (P450EP1A) induced by 2-ethoxyphenol was purified to apparent homogeneity from Corynebacterium sp. strain EP1. The P450EP1Ashowed a single band on sodium dodecyl sulfate-polyacrylamide gel electrophoresis with a molecular weight of about 45 kDa. The CO-reduced difference spectra of P450EP1Ahad a Soret maximum at 447.6 nm. The substrate difference spectra with 2-ethoxyphenol showed an absorption maximum at 394.0 nm. The purified P450EP1Adegraded 2-ethoxyphenol in an assay system composed of spinach ferredoxin-NADP+oxidoreductase and NADPH. The reaction activity decreased to 1.4% of its original activity by addition of CO. The existence of catechol in the reaction mixture was confirmed after the metabolic reaction, indicating that P450EP1Acatalyzes O-dealkylation of 2-ethoxyphenol. In addition to 2-ethoxyphenol, the P450EP1Ametabolized 2-methoxyphenol, 1,1,1-trichloroethane, carbon tetrachloride, benzene, and toluene.Key words: cytochrome P450, Corynebacterium sp., 2-ethoxyphenol, enzyme purification, biodegradation.
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Lupwayi, N. Z., G. W. Clayton, J. T. O’Donovan, K. N. Harker, T. K. Turkington und W. A. Rice. „Decomposition of crop residues under conventional and zero tillage“. Canadian Journal of Soil Science 84, Nr. 4 (01.11.2004): 403–10. http://dx.doi.org/10.4141/s03-082.
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Field experiments were conducted to determine decomposition patterns of red clover (Trifolium pratense), field pea (Pisum sativum), canola (Brassica rapa) and wheat (Triticum aestivum) residues under zero and conventional tillage. Crop residue amounts produced in 2 trial years ranged from 1.6 t ha-1 for monoculture wheat to 6.05 t ha-1 for peas, and tillage had no effect. The extent of dry matter (DM) decomposition was usually less under zero than under conventional tillage, e.g., 31 to 41% of canola DM decomposed under zero tillage while 41 to 50% decomposed under conventional tillage in 12 mo. Corresponding percentages for other residues under zero and conventional tillage, respectively, were: 65 and 75% for clover, 43 and 45 to 55% for pea, and 27 and 40% for wheat. The rate and extent of DM decomposition were positively correlated with N and P concentrations, and negatively correlated with C/N, C/P, lignin/P and lignin/K ratios. These decomposition patterns have implications for nutrient release and soil cover. Rapid decomposition is not necessarily desirable because the nutrients released are subject to losses in soil. Key words: Biological soil quality, crop residue quality, crop rotation
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Donald, David B., William T. Aitken, Carrie Paquette und Shaun S. Wulff. „Winter snowfall determines the occupancy of northern prairie wetlands by tadpoles of the Wood Frog (Lithobates sylvaticus)“. Canadian Journal of Zoology 89, Nr. 11 (November 2011): 1063–73. http://dx.doi.org/10.1139/z11-082.
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In the northern plains of North America, the wetland breeding habitat of amphibians and their populations could be reduced by a change in climate that included decreased precipitation. To test this hypothesis, relative abundance of late-stage tadpoles of the Wood Frog ( Lithobates sylvaticus (LeConte, 1825)) was monitored from 1997 to 2010 during a wet–dry–wet cycle in 29 wetlands distributed throughout central Saskatchewan, Canada. The wetlands were dry for up to 7 consecutive years, and for a mean of 3.8 consecutive years. Consequently, tadpole occupancy of the wetlands was reduced to less than 40% for 5 consecutive years and none of the wetlands had tadpoles during the severe drought of 2001 and 2002. However, the drought had no observable long-term effect on either tadpole occupancy of wetlands or tadpole abundance. In 2007, 93% of the wetlands supported tadpoles, and in 2008 the highest mean relative abundance of tadpoles was recorded. Tadpole occupancy of wetlands was related to winter and spring precipitation (R2 = 0.84) with 67% of long-term variation in occupancy related to snowfall from November to February and 17% related to rainfall from March to June. Less than 45 mm of winter precipitation for 6 consecutive years would probably cause regional extinction of populations of the Wood Frog.
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Lawrence, Derek Joseph, N. Luckai, W. L. Meyer, C. Shahi, A. J. Fazekas, P. Kesanakurti und S. Newmaster. „Distribution of white spruce lateral fine roots as affected by the presence of trembling aspen: root mapping using simple sequence repeat DNA profiling“. Canadian Journal of Forest Research 42, Nr. 8 (August 2012): 1566–76. http://dx.doi.org/10.1139/x2012-082.
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Mixedwood forests of white spruce ( Picea glauca (Moench) Voss) and trembling aspen ( Populus tremuloides Michx.) may possess ecological advantages over monospecific white spruce stands. Belowground competition may be reduced through vertically stratified roots; facilitation of growth may occur in upper soil layers through nutrient-rich trembling aspen litterfall. These effects may incentivize white spruce to preferentially exploit upper soil layers in mixedwood stands, resulting in wider root systems. This research contrasted white spruce fine root (diameter <2 mm) distributions in organic layers of white spruce and mixedwood stands. Research occurred at the Fallingsnow Ecosystem Project site in northwestern Ontario. Eighteen plots represented mixedwood and pure white spruce stands. Trees were mapped; foliage and root samples were collected. Roots were separated by species and scanned to determine length. Simple sequence repeat DNA profiles were determined for all white spruce trees and for 45 white spruce root fragments per plot. Root and tree DNA profiles were matched; corresponding distances were calculated. Most (80%) root fragments were within 3.2 m of tree stems. Root prevalence decreased rapidly with distance. Organic layer pH was significantly less acidic in mixedwood plots, but only in one block. A subtle significant trend towards wider root distributions occurred in mixedwood stands.
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De Brito, Rávilla Endy da Rocha Cunha, und Ruth Silva Lima Da Costa. „LACAZIOSE (DOENÇA DE JORGE LOBO): UM RELATO DE CASO“. REVISTA FOCO 17, Nr. 1 (19.01.2024): e4150. http://dx.doi.org/10.54751/revistafoco.v17n1-082.
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A lacaziose, também conhecida como doença de Jorge Lobo, é uma doença de granulomatosa de caráter crônico, que é causada quando há implantação traumática do fungo Lacazia loboi no tecido cutâneo e subcutâneo. A doença acontece mais em regiões de clima quente e úmido, sendo que, no Brasil, é mais registrada na região amazônica. É observado que são mais acometidas pessoas do sexo masculino, com idade entre 20 e 45 anos, que trabalham em área rural e/ou de floresta. A apresentação clínica é dada, principalmente, por lesões nodulares queloidianas. Os locais mais acometidos são os membros e a face – com destaque para o pavilhão auricular. O objetivo do estudo foi descrever o caso de um paciente acometido por lacaziose. O caso retrata um paciente de 59 anos que começou a apresentar lesão em pavilhão auricular há 22 anos, a qual progrediu em tamanho e disseminação. O diagnóstico aconteceu com auxílio de biópsia, anos depois, e o tratamento foi instituído associando excisão cirúrgica e abordagem medicamentosa. O paciente apresentou diversas recorrências, necessitando de diversas intervenções cirúrgicas. A má adesão ao tratamento medicamentoso é um ponto importante no caso relatado, sendo um fator importante para a análise da recorrência das lesões.
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UKRAINETZ, H., C. A. CAMPBELL, R. P. ZENTNER und M. MONREAL. „RESPONSE OF BROMEGRASS TO N, P AND S FERTILIZER ON A GRAY LUVISOLIC SOIL IN NORTHWESTERN SASKATCHEWAN“. Canadian Journal of Plant Science 68, Nr. 3 (01.07.1988): 687–703. http://dx.doi.org/10.4141/cjps88-082.
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A 9-yr study was conducted on a Gray Luvisolic loam at Loon Lake, Saskatchewan to determine the effect of ammonium nitrate-N (34–0–0) and urea-N (46–0–0) on bromegrass (Bromus inermis Leyss.) production and nutrient quality, N recovery, and N use efficiency when the N was applied either annually or as a single application at the start of the experiment. The effects of phosphorus (P) and sulphur (S) were also assessed. Each N source was applied at single rates of 0, 100, 200, 400 and 800 kg ha−1 N and annual rates of 0, 50, 100 and 200 kg ha−1 N. The ammonium nitrate was also applied as a single dose at rates of 600 and 1000 kg ha−1 N. Phosphorus and S were applied every second year at 224 kg ha−1 P2O5 and 45 kg ha−1 S. Forage dry matter yields were positively related to precipitation received in May and July, and April–May, but negatively related to June precipitation. Forage dry matter production was greater over the first 8-yr period for annual N applications than for a single application receiving an equivalent amount of N; but fertilizer N recovered in forage over the same period was similar (about 30%) for the two methods of application. Dry matter yields were 19% greater after 4 yr and 26% greater after 8 yr when ammonium nitrate was used compared to urea. Recovery of fertilizer N in forage also favored the ammonium nitrate source. The application of low to moderate N rates depressed forage N and P concentrations when yield response was high but concentrations were increased by the highest rates of N fertilizer and by repeated annual applications of N. Toxic concentrations of NO3-N occurred in bromegrass in the first year when N was applied at or above 400 kg ha−1 as one application and also in the second year when N was applied at 800 kg ha−1. When N was applied annually at 200 kg ha−1, NO3-toxicity became a potential problem in later years as soil mineral N accumulated. Phosphorus and S fertilizers increased dry matter yields of forage; P fertilizer increased and S decreased forage P concentration. Annual N applications resulted in more uniform year-to-year yields and N uptake response compared to a single application and provided greater dry matter production without loss of nutritive quality. It was concluded that, in contrast to reports in the literature, the response of forage grasses to N is not site specific.Key words: N source, N recovery, N application method, N use efficiency, phosphorus, sulfur
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Blank, N., J. Henes, T. Kallinich, P. Oommen, C. Schuetz, M. Borte, J. Weber-Arden und J. B. Kuemmerle-Deschner. „POS1380 LONG-TERM EFFICACY AND SAFETY OF CANAKINUMAB IN PATIENTS WITH TRAPS (TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED PERIODIC SYNDROME) - INTERIM ANALYSIS OF THE RELIANCE REGISTRY“. Annals of the Rheumatic Diseases 80, Suppl 1 (19.05.2021): 972–73. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3808.
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Background:Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is a rare autoinflammatory condition characterized by severe systemic and organ inflammation. In a phase 3 pivotal trial (CLUSTER study), TRAPS patients have been successfully treated with the interleukin-1β inhibitor canakinumab. 45% of patients reached clinical remission after 16 weeks (primary endpoint)1. Canakinumab has been approved and applied for the treatment of TRAPS patients since 20172.Objectives:The present study explores the long-term efficacy and safety of canakinumab under routine clinical practice conditions in pediatric (age ≥2 years) and adult TRAPS patients.Methods:RELIANCE is a prospective, non-interventional, multi-center, observational study based in Germany with a 3-year follow-up period. Patients with clinically confirmed diagnoses of TRAPS, CAPS, FMF or HIDS/MKD who routinely receive canakinumab are enrolled in order to evaluate efficacy and safety of canakinumab under standard clinical practice conditions. Disease activity and remission by physician assessment, disease activity and fatigue by patient assessment, days absent from school/work due to study indication, inflammatory markers, and AIDAI (Auto-Inflammatory Diseases Activity Index) score were assessed at baseline and at 6-monthly intervals.Results:The interim analysis of TRAPS patients enrolled by December 2020 includes baseline (N=16, including 1 patient with atypical TRAPS) and preliminary 18-month data. Mean age in this cohort was 23 years (3−43 years) and the median duration of prior CAN treatment was 1.0 year (0−4 years).Physician assessment indicated 60-80% remission and laboratory parameters were within normal range. Disease control by patient assessment showed no major changes regarding the analyzed parameters (Table 1, Figure 1). Of the three serious adverse events reported none was classified as drug-related.Conclusion:Preliminary analysis of 18 month interim data of TRAPS patients treated with CAN available from the RELIANCE study indicate stable efficacy and safety of CAN long-term treatment.References:[1]De Benedetti F, et al. Canakinumab for the treatment of autoinflammatory recurrent fever syndromes. N Engl J Med 2018;378:1908–19.[2]Ilaris, INN-canakinumab (europa.eu)Table 1.Baseline characteristics and interim analysis data of patients with TRAPSBaseline6 months12 months18 monthsNumber of patients, N1613106Median age, years (min; max)23 (3; 43)17 (3; 43)16 (4; 38)25 (4; 43)Females (%)11 (69)9 (69)7 (70)3 (50)Median duration of prior CAN therapy at baseline, years (min; max)1.0 (0; 4)1.0 (0; 4)1.0 (0; 4)1.5 (0; 2)Number (%) of patients in disease remission (physician assessment)9 (60.0)9 (81.8)7 (77.8)4 (80.0)Physician Global Assessment, percentage of absent/mild-moderate/severe rating40 / 53 / 082 / 9 / 044 / 44 / 1180 / 20 / 0Patient assessment of current disease activity; 0–10, median (min; max)1.5 (0; 5)1.0 (0; 4)1.0 (0; 6)0.0 (0; 3)Patient assessment of current fatigue; 0–10, median (min; max)2.0 (0; 8)1.0 (0; 7)2,5 (0; 8)4.0 (0; 7)Number (%) of patients without impairment of social life by the disease4 (50)5 (63)2 (33)3 (60)Number (%) of patients with days absent from work/school during last 6 months8 (50)5 (39)5 (56)3 (50)CRP, median (mg/dl)0.10.10.10.0SAA, median (mg/dl)0.50.40.40.3ESR, median (mm/h)7.05.05.05.0SAENumber of eventsIncidence rate per 100 patient yearsTotal314.7Circulatory collapse (non fatal)14.9Dizziness14.9Headache14.9CRP, c-reactive protein; ESR, erythrocyte sedimentation rate; SAA, serum amyloid A; SAE, serious adverse eventDisclosure of Interests:Norbert Blank Consultant of: Novartis, Sobi, Lilly, Pfizer, Abbvie, BMS, MSD, Actelion, UCB, Boehringer-Ingelheim, Roche, Grant/research support from: Novartis, Sobi, Jörg Henes Consultant of: Novartis, AbbVie, Sobi, Roche, Janssen, Boehringer-Ingelheim, Grant/research support from: Novartis, Roche, Tilmann Kallinich Consultant of: Sobi, Novartis, Roche, Grant/research support from: Novartis, Prasad Oommen Grant/research support from: Novartis, Catharina Schuetz: None declared, Michael Borte Grant/research support from: Pfizer, Shire, Julia Weber-Arden Employee of: Novartis, J. B. Kuemmerle-Deschner Consultant of: Novartis, AbbVie, Sobi, Grant/research support from: Novartis, AbbVie, Sobi
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Chiappella, Annalisa, Benedetta Puccini, Marianna Rossi, Simone Ferrero, Luca Arcaini, Ernesta Audisio, Ileana Baldi et al. „Mantle Cell International Prognostic Index (MIPI) Is a Strong Predictor of the Outcome of Mantle Cell Lymphoma (MCL) in the Rituximab (R) Era.“ Blood 114, Nr. 22 (20.11.2009): 2928. http://dx.doi.org/10.1182/blood.v114.22.2928.2928.
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Abstract Abstract 2928 Poster Board II-904 Introduction: A new prognostic clinical index (MIPI) and a biological one with cell proliferation (Ki-67) evaluation (MIPIb), were defined specifically for MCL to give a more reliable estimation of outcome (Hoster 2008). Aim of our analysis was to test MIPI and MIPIb on a retrospective series of MCL patients treated with R-chemotherapy. Patients and methods: Between 1999 and 2008, 136 MCL at diagnosis consecutively treated in five institutions entered into the study. Histology was centrally reviewed. Clinical characteristics were: median age 62 (37-84) years, 78% stage IV, 73% with bone marrow involvement and 15% with blastoid variant. First-line treatments were: R-high-dose chemotherapy with Autologous Stem Cell Transplantation (R-HDC) in 48 patients, R-Fludarabine based chemotherapy in 22, R-CHOP-like in 50 and other R containing regimens in 16. Ki-67 evaluation was performed in 93 patients; 43 were not, due to inadequate pathological materials. Overall Survival (OS) and failure-free survival (FFS) curves were estimated both overall and stratified by MIPI, MIPIb and IPI score. Differences between curves were tested using the 2-tailed log-rank test. In order to quantify the predictive discrimination of MIPI, MIPIb and IPI scores, in a subgroup of 84 patients fulfilled MIPI, MIPIb and IPI scores, a Cox's model analysis and univariate logistic models (with death and failure event as binary outcomes) were fitted and the area under the receiver operating characteristic (ROC) curves (c-index) was estimated. Results: Prognostic index stratification was as follows: according to MIPI 45 patients (33%) were at low-risk (LR, 0-3), 36 (26%) at intermediate-risk (IR, 4-5), 43 (32%) at high-risk (HR, >5) and 12 missing; according to MIPIb 70 patients (51%) were at LR (0-5.699), 7 (5%) at IR (5.7-6.499), 16 (12%) at HR (>6.5) and 43 missing; according to IPI 38 patients (28%) were at LR, 41 (30%) at LIR, 47 (35%) at IH-HR and 10 missing. Responses were as follows: complete 74, partial 29, no response 22, not yet evaluable 11. With a median follow-up of 28 months, 2-year OS was 80% (95% CI:71%-86%) and 2-year FFS was 60% (95%CI: 51%-69%). 2-year OS and 2-year FFS rates according to MIPI, MIPIb and IPI were shown in table 1. Eighty-four patients had all the factors to accurately calculate MIPI, MIPIb and IPI; in this subgroup, an univariate logistic model and a Cox's model including the time at the event were performed. The c-index and Cox-index for death event were 73% and 77% for MIPI, 72% and 73% for MIPIb, 67% and 65% for IPI respectively; the c-index and Cox-index for failure event were 66% and 72% for MIPI, 66% and 65% for MIPIb, 67% and 64% for IPI respectively. A further analysis for death event was performed to adjust the effect of MIPI for other known risk factors (Ann-Arbor stage, Bone Marrow involvement, blastoid variant, number of extranodal sites). In a Cox model, MIPI score and number of extranodal sites were confirmed as independent predictors of death event: adjusted hazard ratio was 8.75 (95%CI: 3.14-24.4, p=<.0001) for MIPI-HR group vs MIPI-LR, and 5.97 (95%CI: 0.80-44.59, p=.082) for at least one extranodal site. Discussion: MIPI score was confirmed as a strong predictor of death event in MCL retrospective patients treated with R-chemotherapy regimens. New therapeutic strategies are warranted to improve the outcome of MCL namely in MIPI-HR group. Disclosures: Ladetto: CELGENE: Honoraria; JANSSEN-CILAG: Research Funding. Vitolo:Roche:.
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Petrie, Mark J., Joseph P. Fleskes, Mike A. Wolder, Craig R. Isola, Gregory S. Yarris und Daniel A. Skalos. „Potential Effects of Drought on Carrying Capacity for Wintering Waterfowl in the Central Valley of California“. Journal of Fish and Wildlife Management 7, Nr. 2 (01.09.2016): 408–22. http://dx.doi.org/10.3996/082015-jfwm-082.
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Abstract We used the bioenergetics model TRUEMET to evaluate potential effects of California's recent drought on food supplies for waterfowl wintering in the Central Valley under a range of habitat and waterfowl population scenarios. In nondrought years in the current Central Valley landscape, food supplies are projected to be adequate for waterfowl from fall through early spring (except late March) even if waterfowl populations reach North American Waterfowl Management Plan goals. However, in all drought scenarios that we evaluated, food supplies were projected to be exhausted for ducks by mid- to late winter and by late winter or early spring for geese. For ducks, these results were strongly related to projected declines in winter-flooded rice fields that provide 45% of all the food energy available to ducks in the Central Valley in nondrought water years. Delayed flooding of some managed wetlands may help alleviate food shortages by providing wetland food resources better timed with waterfowl migration and abundance patterns in the Central Valley, as well as reducing the amount of water needed to manage these habitats. However, future research is needed to evaluate the impacts of delayed flooding on waterfowl hunting, and whether California's existing water delivery system would make delayed flooding feasible. Securing adequate water supplies for waterfowl and other wetland-dependent birds is among the greatest challenges facing resource managers in coming years, especially in the increasingly arid western United States.
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Maharramov, S. „Econometric Assessment of Azerbaijan's Logistics Capabilities in Terms of Relations with Turkic-Speaking States“. Economic Herald of the Donbas, Nr. 4 (66) (2021): 45–52. http://dx.doi.org/10.12958/1817-3772-2021-4(66)-45-52.
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Modern world grows very fast every day. The main arrow of every state economy is logistics sector, which is increasing very dynamically. The Turkic Speaking States are locating on the Historical Great Silk Road. The total of territory and population of those countries are 4 732 082 km2 and 157 949 505 people. After collapsing the USSR, the five Turkic Speaking States get independence (Azerbaijan, Kazakhstan, Uzbekistan, Turkmenistan and Kyrgyzstan), economy and political policy of those states have been changed to the modern market rules. The most of those countries economy base on the raw materials, gas and petroleum. For exporting of all those raw materials the States need strong logistics systems. The article illustrates the economic development of logistics sectors and trade over between Turkic Speaking States. This research will help to open the problems and find out the solution, implementation of the logistics policy for all of them. Using strong and different fundamental databases, such as statistic of those countries, trade balance, logistics relations, import and export dates, different correlation methods and economic models, the international resource and powerful academic literature help to describe the potential of economy relation and real situations, perspectives, problems and logistics power of the Turkic Speaking States.
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Wilson, Andrew. „Detritus, disease and death in the city - Xavier Dupré Raventós y Josep-Anton Remolà, SORDES URBIS. LA ELIMINACIÓN DE RESIDUOS EN LA CIUDAD ROMANA. ACTAS DE LA REUNIÓN DE ROME (15-16 DE NOVIEMBRE DE 1996) (Bibliotheca Italica: Monografías de la Escuela Española de Historia y Arqueología en Roma n° 24; L'Erma di Bretschneider, Roma 2000). Pp. xv + 150, 38 figs. ISBN 88-8265-082-0. - Valerie M. Hope and Eireann Marshall (edd.), DEATH AND DISEASE IN THE ANCIENT CITY (Routledge, London 2000). Pp. xii + 194. ISBN 0-415-21427-0. £45.“ Journal of Roman Archaeology 15 (2002): 479–84. http://dx.doi.org/10.1017/s1047759400014264.
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Moya-Salazar, Jeel, Marleny Ccorahua, Eliane A. Goicochea-Palomino, Jeel G. Moya-Espinoza und Hans Contreras-Pulache. „Favorable Attitudes Toward Research in Nursing Students During Internship: A Cross-Sectional Study in Peru“. SAGE Open Nursing 9 (Januar 2023). http://dx.doi.org/10.1177/23779608231206776.
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Introduction and objective Research attitudes among nursing students are essential to improve the quality of care and promote evidence-based practice. The objective of this study was to determine the attitude towards research of nursing students during their undergraduate internship and explore the demographic and study-related factors that may affect these attitudes. Materials and Methods In this cross-sectional retrospective study, 100 nursing interns who are >18 years old, currently studying and working, and have a prior academic background were included. To assess the attitudes toward research, the 43-item Likert-like Scale of Attitudes Towards Research questionnaire was used, which has been previously validated in the Peruvian population and includes three distinct dimensions: affective, cognitive, and behavioral. Results The mean age was 28.7 ± 5.2 years and 88% were women. Fifty percent had favorable attitudes toward research. The favorable attitude according to the affective, cognitive, and behavioral dimensions was 28%, 11%, and 45%, respectively. Although the youngest age group (20 to 30 years old) had the highest frequency of favorable attitudes (36%), no significant differences were found when compared to other age groups ( p = .082). Conclusions Nursing students presented favorable attitudes toward research during their undergraduate internship, especially among young students. However, more research is needed to understand how these attitudes are shaped and consolidated during the research process and how they can be further improved to promote evidence-based practice in nursing.
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Kharma, Nadir, Stefan Roehrig, Ahmed Atef Shible, Moustafa Sayed Elshafei, Dema Osman, Ingi Mohamed Elsaid, Salma Faisal Mustafa, Asjad Aldabi, Osamah A. M. Smain und Marcus D. Lance. „Anticoagulation in critically ill patients on mechanical ventilation suffering from COVID-19 disease, The ANTI-CO trial: A structured summary of a study protocol for a randomised controlled trial“. Trials 21, Nr. 1 (07.09.2020). http://dx.doi.org/10.1186/s13063-020-04689-1.
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Abstract Objectives To assess the effect of anticoagulation with bivalirudin administered intravenously on gas-exchange in patients with COVID-19 and respiratory failure using invasive mechanical ventilation. Trial design This is a single centre parallel group, superiority, randomized (1:1 allocation ratio) controlled trial. Participants All patients admitted to the Hamad Medical Corporation -ICU in Qatar for COVID-19 associated respiratory distress and in need of mechanical ventilation are screened for eligibility. Inclusion criteria: all adult patients admitted to the ICU who test positive for COVID-19 by PCR-test and in need for mechanical ventilation are eligible for inclusion. Upon crossing the limit of D-dimers (1.2 mg/L) these patients are routinely treated with an increased dose of anticoagulant according to our local protocol. This will be the start of randomization. Exclusion criteria: pregnancy, allergic to the drug, inherited coagulation abnormalities, no informed consent. Intervention and comparator The intervention group will receive the anticoagulant bivalirudin intravenously with a target aPTT of 45-70 sec for three days while the control group will stay on the standard treatment with low-molecular-weight heparins /unfractionated heparin subcutaneously (see scheme in Additional file 1). All other treatment will be unchanged and left to the attending physicians. Main outcomes As a surrogate parameter for clinical improvement and primary outcome we will use the PaO2/FiO2 (P/F) ratio. Randomisation After inclusion, the patients will be randomized using a closed envelope method into the conventional treatment group, which uses the standard strategy and the experimental group which receives anticoagulation treatment with bivalirudin using an allocation ratio of 1:1. Blinding (masking) Due to logistical and safety reasons (assessment of aPTT to titrate the study drug) only the data-analyst will be blinded to the groups. Numbers to be randomised (sample size) We performed a sample size calculation and assumed the data for P/F ratio (according to literature) is normally distributed and used the mean which would be: 160 and SD is 80. We expect the treatment will improve this by 30%. In order to reach a power of 80% we would need 44 patients per group (in total 88 patients). Taking approximately 10% of dropout into account we will include 100 patients (50 in each group). Trial Status The local registration number is MRC-05-082 with the protocol version number 2. The date of approval is 18th June 2020. Recruitment started on 28th June and is expected to end in November 2020. Trial registration The protocol is registered before starting subject recruitment under the title: “Anticoagulation in patients suffering from COVID-19 disease. The ANTI-CO Trial” in ClinicalTrials.org with the registration number: NCT04445935. Registered on 24 June 2020. Full protocol The full protocol is attached as an additional file, accessible from the Trials website (Additional file 2). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol.
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Rugescu, I. A., R. Dumitrescu, D. Dinu Draganescu, A. Botezatu, A. Albulescu, A. Fudulu, A. Plesa et al. „P-082 Estradiol levels in idiopathic male infertility“. Human Reproduction 38, Supplement_1 (01.06.2023). http://dx.doi.org/10.1093/humrep/dead093.447.
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Abstract Study question Investigating estradiol in relation with other sperm parameters might reveal new correlations which would help our understanding of male idiopathic infertility Summary answer Statistical significance was found in a series of correlations of E2 levels and sperm, hormonal and health parameters What is known already Male infertility is a rising major health concern, with sperm counts decreasing by 50-60% in the recent decades. The causes for male infertility are very different (genetic, systemic, neurological, infections, trauma, etc.), but at least 44% of cases are idiopathic. Estradiol (E2) regulates spermatogenesis by binding to classical intracellular estrogen receptors or membrane estrogen receptors to trigger genomic and nongenomic signal transduction pathways. Although E2 doesn’t carry any prognostic value by itself, as its levels don’t vary significantly between infertile and fertile men, its association with other parameters may lead to a better understanding of male infertility Study design, size, duration the design of cross-sectional study comprising 111 subjects- 87 infertile patients (median: 34 years, range 20–55 years) and 24 control (median: 33 years, range 20–45 years). The subjects were included in this study during 3 years (between October 2019- September2022). Inclusion criteria: spermatic parameters according to WHO 2010 Standards Exclusion criteria: Radiotherapy and/or pelvic chemotherapy (over the last 6 months), known genetic aberrations, endocrine diseases, urogenital infections, bilateral orchiectomy, vasectomy and occupational exposure. Participants/materials, setting, methods Infertile men were grouped in azoospermia (AZOO), oligoasthenoteratozoospermia (OATS/OATSS) and oligoasthenozoospermia (OAS/OASS). Blood and semen samples were collected and E2 levels were measured in both seminal and blood samples, along with sperm parameters (sperm count, motility, morphology) and other factors (BMI, hormone and vitamin D levels, BsmI polymorphism in the vitamin D receptor gene) were evaluated. E2 levels were assayed using the electrochemiluminescence method with the RocheCobas E601 autoanalyzer. Main results and the role of chance E2 varies slightly between the different patients’ groups, the highest values being found in the OAT/OATSS group. BMI is higher in the infertile group; significant higher values were found for the OAS/OASS (p = 0.002) and OATS/OATS (p = 0.017) groups. Statistical analysis has revealed a significant difference between serum and seminal E2 levels in each group (AZOO p = 0.0355; OATS/OATSS p = 0.0156; control p = 0.0009), but also between OATS/OATSS seminal group and control seminal group (p = 0.0366). The E2/Inhibin ratio presented higher values in patients with OATS/OATSS (p = 0.0031) and azoospermia (p = 0.0059). The lowest values of E2/Vitamin D ratio were detected in the OAS/OASS and OATS/OATSS groups (p = 0.0254), A significant increase of E2 serum level was observed in patients from the OATS/OATSS group in the case of homozygous for mutant allele of BsmI polymorphism (p = 0.0419). The results bring new evidence regarding the role of E2 in male infertility. The obtained data indicates an interplay between E2 and Inhibin B and vitamin D serum levels, highlighting it’s the role in male infertility. Limitations, reasons for caution The study could be extended to a larger population sample, in order to further validate the obtained results Wider implications of the findings Estradiol activity plays an important role in male fertility and along with the investigated parameters could serve as potential markers in the diagnosis and management of male infertility. Trial registration number PN-III-P2-2.1-PED-2019-4402