Thematische Bibliographien / 3-hydroxy fatty acids

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  2. Dissertationen
  3. Buchteile
  4. Konferenzberichte

Auswahl der wissenschaftlichen Literatur zum Thema „3-hydroxy fatty acids“

Autor: Grafiati
Veröffentlicht am 25. Mai 2024

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Zeitschriftenartikel zum Thema "3-hydroxy fatty acids"

1

Wood, Paul L. „Fatty Acyl Esters of Hydroxy Fatty Acid (FAHFA) Lipid Families“. Metabolites 10, Nr. 12 (17.12.2020): 512. http://dx.doi.org/10.3390/metabo10120512.

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Fatty Acyl esters of Hydroxy Fatty Acids (FAHFA) encompass three different lipid families which have incorrectly been classified as wax esters. These families include (i) Branched-chain FAHFAs, involved in the regulation of glucose metabolism and inflammation, with acylation of an internal branched-chain hydroxy-palmitic or -stearic acid; (ii) ω-FAHFAs, which function as biosurfactants in a number of biofluids, are formed via acylation of the ω-hydroxyl group of very-long-chain fatty acids (these lipids have also been designated as o-acyl hydroxy fatty acids; OAHFA); and (iii) Ornithine-FAHFAs are bacterial lipids formed by the acylation of short-chain 3-hydroxy fatty acids and the addition of ornithine to the free carboxy group of the hydroxy fatty acid. The differences in biosynthetic pathways and cellular functions of these lipid families will be reviewed and compared to wax esters, which are formed by the acylation of a fatty alcohol, not a hydroxy fatty acid. In summary, FAHFA lipid families are both unique and complex in their biosynthesis and their biological actions. We have only evaluated the tip of the iceberg and much more exciting research is required to understand these lipids in health and disease.
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Nichols, Frank, und Baliram Maraj. „Relationship between Hydroxy Fatty Acids and Prostaglandin E2 in Gingival Tissue“. Infection and Immunity 66, Nr. 12 (01.12.1998): 5805–11. http://dx.doi.org/10.1128/iai.66.12.5805-5811.1998.

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ABSTRACT Bacterial hydroxy fatty acids and alpha-hydroxy fatty acids have been demonstrated in complex lipid extracts of subgingival plaque and gingival tissue. However, little is known about the relationship between these hydroxy fatty acids in plaque and gingival tissues or the significance of these complex lipids in promoting inflammatory periodontal disease. The present study determined the percentages of ester-linked and amide-linked hydroxy fatty acids in complex lipids recovered from plaque and gingival tissue samples and the relationship between bacterial hydroxy fatty acids and alpha-hydroxy fatty acids in the lipid extracts. To evaluate a potential role for these hydroxy fatty acids in inflammatory periodontal disease, gingival tissue samples were examined for a relationship between prostaglandin E2 (PGE2) and hydroxy fatty acids recovered in gingival lipid. This investigation demonstrated that alpha-hydroxy fatty acids are only ester linked in plaque lipids but are largely amide linked in gingival tissue lipids. Furthermore, the level of alpha-hydroxy fatty acid in gingival lipid is directly related to the level of the bacterial hydroxy fatty acid 3-OHiso-branched C17:0 (3-OH iC17:0) in the same lipid extract. However, the relationship between hydroxy fatty acids in gingival lipids does not parallel the fatty acid relationship observed in plaque lipids. Finally, alpha-hydroxy fatty acid levels in gingival tissue lipids correlate directly with the recovery of PGE2 in the same tissue samples. These results demonstrate that alpha-hydroxy fatty acid levels in gingival lipids are directly related to both 3-OH iC17:0 bacterial lipid levels and PGE2 levels. These results indicate that in periodontal tissues there are unusual host-parasite interactions involving penetration of bacterial lipid in association with an altered gingival lipid metabolism and prostaglandin synthesis.
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Yang, Nian-Yun, Yi-Fang Yang und Kun Li. „Analysis of Hydroxy Fatty Acids from the Pollen of Brassica campestris L. var. oleifera DC. by UPLC-MS/MS“. Journal of Pharmaceutics 2013 (10.10.2013): 1–6. http://dx.doi.org/10.1155/2013/874875.

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Ultraperformance liquid chromatography coupled with negative electrospray tandem mass spectrometry (UPLC-ESI-MS/MS) was used to determine 7 hydroxy fatty acids in the pollen of Brassica campestris L. var. oleifera DC. All the investigated hydroxy fatty acids showed strong deprotonated molecular ions [M–H]−, which underwent two major fragment pathways of the allyl scission and the β-fission of the alcoholic hydroxyl group. By comparison of their molecular ions and abundant fragment ions with those of reference compounds, they were tentatively assigned as 15,16-dihydroxy-9Z,12Z-octadecadienoic acid (1), 10,11,12-trihydroxy-(7Z,14Z)-heptadecadienoic acid (2), 7,15,16-trihydroxy-9Z,12Z-octadecadienoic acid (3), 15,16-dihydroxy-9Z,12Z-octadecadienoic acid (4), 15-hydroxy-6Z,9Z,12Z-octadecatrienoic acid (5), 15-hydroxy-9Z,12Z- octadecadienoic acid (6), and 15-hydroxy-12Z-octadecaenoic acid (7), respectively. Compounds 3, 5, and 7 are reported for the first time.
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Bourboula, Asimina, Dimitris Limnios, Maroula G. Kokotou, Olga G. Mountanea und George Kokotos. „Enantioselective Organocatalysis-Based Synthesis of 3-Hydroxy Fatty Acids and Fatty γ-Lactones“. Molecules 24, Nr. 11 (31.05.2019): 2081. http://dx.doi.org/10.3390/molecules24112081.

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3-Hydroxy fatty acids have attracted the interest of researchers, since some of them may interact with free fatty acid receptors more effectively than their non-hydroxylated counterparts and their determination in plasma provides diagnostic information regarding mitochondrial deficiency. We present here the development of a convenient and general methodology for the asymmetric synthesis of 3-hydroxy fatty acids. The enantioselective organocatalytic synthesis of terminal epoxides, starting from long chain aldehydes, is the key-step of our methodology, followed by ring opening with vinylmagnesium bromide. Ozonolysis and subsequent oxidation leads to the target products. MacMillan’s third generation imidazolidinone organocatalyst has been employed for the epoxide formation, ensuring products in high enantiomeric purity. Furthermore, a route for the incorporation of deuterium on the carbon atom carrying the hydroxy group was developed allowing the synthesis of deuterated derivatives, which may be useful in biological studies and in mass spectrometry studies. In addition, the synthesis of fatty γ-lactones, corresponding to 4-hydroxy fatty acids, was also explored.
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Sjögren, Jörgen, Jesper Magnusson, Anders Broberg, Johan Schnürer und Lennart Kenne. „Antifungal 3-Hydroxy Fatty Acids from Lactobacillus plantarum MiLAB 14“. Applied and Environmental Microbiology 69, Nr. 12 (Dezember 2003): 7554–57. http://dx.doi.org/10.1128/aem.69.12.7554-7557.2003.

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ABSTRACT We report the identification and chemical characterization of four antifungal substances, 3-(R)-hydroxydecanoic acid, 3-hydroxy-5-cis-dodecenoic acid, 3-(R)-hydroxydodecanoic acid and 3-(R)-hydroxytetradecanoic acid, from Lactobacillus plantarum MiLAB 14. The concentrations of the 3-hydroxy fatty acids in the supernatant followed the bacterial growth. Racemic mixtures of the saturated 3-hydroxy fatty acids showed antifungal activity against different molds and yeasts with MICs between 10 and 100 μg ml−1.
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Nawabi, Parwez, Stefan Bauer, Nikos Kyrpides und Athanasios Lykidis. „Engineering Escherichia coli for Biodiesel Production Utilizing a Bacterial Fatty Acid Methyltransferase“. Applied and Environmental Microbiology 77, Nr. 22 (16.09.2011): 8052–61. http://dx.doi.org/10.1128/aem.05046-11.

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ABSTRACTThe production of low-cost biofuels in engineered microorganisms is of great interest due to the continual increase in the world's energy demands. Biodiesel is a renewable fuel that can potentially be produced in microbes cost-effectively. Fatty acid methyl esters (FAMEs) are a common component of biodiesel and can be synthesized from either triacylglycerol or free fatty acids (FFAs). Here we report the identification of a novel bacterial fatty acid methyltransferase (FAMT) that catalyzes the formation of FAMEs and 3-hydroxyl fatty acid methyl esters (3-OH-FAMEs) from the respective free acids andS-adenosylmethionine (AdoMet). FAMT exhibits a higher specificity toward 3-hydroxy free fatty acids (3-OH-FFAs) than FFAs, synthesizing 3-hydroxy fatty acid methyl esters (3-OH-FAMEs)in vivo. We have also identified bacterial members of the fatty acyl-acyl carrier protein (ACP) thioesterase (FAT) enzyme family with distinct acyl chain specificities. These bacterial FATs exhibit increased specificity toward 3-hydroxyacyl-ACP, generating 3-OH-FFAs, which can subsequently be utilized by FAMTs to produce 3-OH-FAMEs. PhaG (3-hydroxyacyl ACP:coenzyme A [CoA] transacylase) constitutes an alternative route to 3-OH-FFA synthesis; the coexpression of PhaG with FAMT led to the highest level of accumulation of 3-OH-FAMEs and FAMEs. The availability of AdoMet, the second substrate for FAMT, is an important factor regulating the amount of methyl esters produced by bacterial cells. Our results indicate that the deletion of the global methionine regulatormetJand the overexpression of methionine adenosyltransferase result in increased methyl ester synthesis.
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Sebolai, Olihile M., Carolina H. Pohl, Piet J. Botes, Catharina J. Strauss, Pieter W. J. van Wyk, Alfred Botha und Johan L. F. Kock. „3-Hydroxy fatty acids found in capsules ofCryptococcus neoformans“. Canadian Journal of Microbiology 53, Nr. 6 (Juni 2007): 809–12. http://dx.doi.org/10.1139/w07-045.

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Venter, Pierre, Johan L. F. Kock, Dennis J. Coetzee, Piet J. Botes und Santosh Nigam. „The production of 3-Hydroxy fatty acids by yeast“. Prostaglandins & Other Lipid Mediators 59, Nr. 1-6 (Dezember 1999): 198. http://dx.doi.org/10.1016/s0090-6980(99)90433-1.

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Jacob, Jürgen, und Gottfried Raab. „2,3-Dihydroxy Fatty Acids-Containing Waxes in Storks (C iconiidae)“. Zeitschrift für Naturforschung C 51, Nr. 9-10 (01.10.1996): 743–49. http://dx.doi.org/10.1515/znc-1996-9-1021.

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Uropygial gland secretions from five out of a total of seven species forming the genus Ciconia (family Ciconiidae; order Ciconiiformes) were found to consist of mixtures of monoester waxes, diester waxes, triester waxes, and triglycerides. Monoester waxes were composed of unbranched fatty acids and alcohols, whereas diester waxes derived from both 2- and 3-hydroxy fatty acids esterified with unbranched alcohols and fatty acids. Interestingly, triester waxes were also found deriving from either 2-hydroxy alkylmalonic acids or from erythro-2,3-dihydroxy fatty acids the latter of which have not yet been found in vertebrates so far. To compare the typical mass spectrometric fragmentation of this class of compounds erythro-2,3-dihydroxyhexadecanoic acid has been synthesized
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Guichardant, M., und M. Lagarde. „Monohydroxylated fatty acid substrate specificity of human leukocyte 5-lipoxygenase and ω-hydroxylase“. Biochemical Journal 256, Nr. 3 (15.12.1988): 879–83. http://dx.doi.org/10.1042/bj2560879.

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Various monohydroxylated fatty acids were synthesized from eicosapolyenoic acids, namely arachidonic (20:4 omega-6), timnodonic (20:5 omega-3), dihomogammalinolenic (20:3 omega-6) and mead (20:3 omega-9) acids. 12-Hydroxy derivatives, as well as 12-hydroxy-5,8,10-heptadecatrienoic acid (HHT), were produced with platelets as the enzyme source, and 15-hydroxy derivatives were produced by soya bean lipoxygenase treatment. Each monohydroxylated fatty acid was incubated with human leukocytes in the presence or absence of the calcium ionophore A23187, and dihydroxylated products were analysed by h.p.l.c. 12-Hydroxy derivatives of 20:4 omega-6, 20:5 omega-3 and 20:3 omega-9 were similarly oxygenated by both the 5-lipoxygenase and the omega-hydroxylase. As expected, the 12-hydroxy derivative of 20:3 omega-6 was not a substrate for 5-lipoxygenase, but surprisingly, omega-6 oxygenated products, like 15-OH-20:4 or HHT, were not converted by the enzyme, although being potential substrates because of the presence of two double bonds at C-5 and C-8. omega-6 oxygenated derivatives were also poorly converted by leukotriene B4 omega-hydroxylase, a cytochrome P-450-dependent enzyme. It is concluded that both leukocyte 5-lipoxygenase and omega-hydroxylase exhibit a substrate specificity towards monohydroxylated fatty acids with respect to their double bonds and/or the carbon position of the alcohol function.
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Dissertationen zum Thema "3-hydroxy fatty acids"

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Jenske, Ramona. „Compound specific and enantioselective determination of 2- and 3-hydroxy fatty acids in food“. Aachen Shaker, 2009. http://d-nb.info/996919910/04.

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McDaniel, J., Karen A. Massey und Anna Nicolaou. „Fish oil supplementation alters levels of lipid mediators of inflammation in microenvironment of acute human wounds“. Wiley, 2010. http://hdl.handle.net/10454/4577.

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Chronic wounds often result from prolonged inflammation involving excessive polymorphonuclear leukocyte activity. Studies show that the omega-3 polyunsaturated fatty acids eicosapentaenoic and docosahexaenoic acids found in fish oils generate bioactive lipid mediators that reduce inflammation and polymorphonuclear leukocyte recruitment in numerous inflammatory disease models. The purpose of this study was to test the hypotheses that boosting plasma levels of eicosapentaenoic and docosahexaenoic acids with oral supplementation would alter lipid mediator levels in acute wound microenvironments and reduce polymorphonuclear leukocyte levels. Eighteen individuals were randomized to 28 days of either eicosapentaenoic + docosahexaenoic acid supplementation (Active Group) or placebo. After 28 days the Active Group had significantly higher plasma levels of eicosapentaenoic (p<0.001) and docosahexaenoic acid (p<0.001) than the Placebo Group and significantly lower wound fluid levels of two 15-lipoxygenase products of omega-6 polyunsaturated fatty acids, [9- hydroxyoctadecadienoic (HODE) acid (p = 0.033) and15-hydroxyeicosatrienoic acid (HETrE) (p = 0.006)], at 24 hours post wounding. The Active Group also had lower mean levels of myeloperoxidase, a leukocyte marker, at 12 hours and significantly more re-epithelialization on Day 5 post wounding. We suggest that lipid mediator profiles can be manipulated by altering polyunsaturated fatty acid intake to create a wound microenvironment more conducive to healing.
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Jenske, Ramona [Verfasser]. „Compound-Specific and Enantioselective Determination of 2- and 3-Hydroxy Fatty Acids in Food / Ramona Jenske“. Aachen : Shaker, 2009. http://d-nb.info/1159835012/34.

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Kiezel-Tsugunova, Magdalena. „Elucidating the metabolism of n-3 polyunsaturated fatty acids and formation of bioactive lipid mediators in human skin“. Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/elucidating-the-metabolism-of-n3-polyunsaturated-fatty-acids-and-formation-of-bioactive-lipid-mediators-in-human-skin(773abedd-c726-4dab-890a-694a96b1c074).html.

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Human skin has distinct lipid metabolism and production of bioactive lipid mediators that can be modulated by nutritional supplementation with omega-3 polyunsaturated fatty acids (n-3 PUFA), of which eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids exert anti-inflammatory effects. The aims of this project were to gain better understanding of their individual mechanisms in human epidermis and dermis. HaCaT keratinocytes, 46BR.1N fibroblasts, primary human epidermal keratinocytes and dermal fibroblasts were treated with EPA or DHA for 72h and then sham-irradiated or exposed to 15 mJ/cm2 ultraviolet radiation (UVR). Viability was measured by the MTT assay. The expression of cyclooxygenase-2 (COX-2), microsomal prostaglandin synthase-1 (mPGES-1) and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) proteins was explored by western blotting. Human skin explants (n=4 donors) were cultured for 3 or 6 days and supplemented with EPA, DHA or vehicle. Culture media were collected to evaluate tissue damage and PUFA cytotoxicity (lactate dehydrogenase assay). Epidermal and dermal lipid profiles were assessed by gas chromatography and liquid chromatography coupled to tandem mass spectrometry. Primary keratinocytes were treated with fatty acids and various lipid mediators for 48h. Their effect was determined by the scratch assay and transepithelial electrical resistance. UVR upregulated COX-2 in HaCaT and primary epidermal keratinocytes, but did not affect mPGES-1 and 15-PGDH protein expression. UVR upregulated COX-2 and mPGES-1 in 46BR.1N fibroblasts but had no effect on 15-PGDH expression. The same UVR dose did not alter the expression of COX-2, mPGES-1 and 15-PGDH in primary dermal fibroblasts. Only EPA attenuated COX-2 expression in HaCaT and primary keratinocytes and either EPA or DHA had any effect in 46BR.1N and primary fibroblasts. Skin explants showed initial post-biopsy tissue damage. EPA and DHA supplementation augmented cellular levels of the corresponding fatty acids in both epidermis and dermis to a different extent. Increased uptake of DHA in the dermis was accompanied by reduced arachidonic acid levels. EPA treatment stimulated the production of PGE3 and various HEPE in epidermis, while DHA treatment caused high levels of HDHA species in dermis. N-3 PUFA and their derivatives delayed wound healing, cell migration and epidermal barrier permeability, while n-6 PUFA lipids showed the opposite effect. Overall, these findings suggest that EPA and DHA differently affect skin cells and skin, with EPA preference in epidermis and DHA in the dermis. These results highlight the importance of differential skin responses that could be important in skin health and disease.
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Awada, Manar. „L’oxydation modifie les effets métaboliques d'acides gras polyinsaturés de la série n-3 incorporés par différents vecteurs dans des régimes hyperlipidiques : contribution de l’absorption intestinale et de la réactivité cellulaire du 4-hydroxy-hexénal“. Thesis, Lyon, INSA, 2012. http://www.theses.fr/2012ISAL0143/document.

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Les aliments riches en acides gras polyinsaturés (AGPI) à longue chaîne (LC) de la série n-3 sont recommandés pour leurs effets bénéfiques sur la santé humaine et en particulier dans la prevention du développement des maladies métaboliques. Or, la biodisponibilité de ces AGPI et leur impact métabolique pourraient être modulés par la nature chimique des molécules qui les véhiculent dans les aliments (triacylglycérols, TG ou phospholipides, PL). De plus, ces AGPI sont sensibles à la peroxydation lipidique. S’ils ne sont pas protégés de l’oxydation, ils peuvent former des espèces réactives toxiques comme le 4-hydroxy-hexénal (4-HHE). Dans ce contexte, le but de notre étude a été d’évaluer l’impact de l’enrichissement de régimes hyperlipidiques en AGPI n-3 (i) portés par des TG ou des PL et (ii) sous forme non-oxydée ou oxydée, sur l’inflammation et le stress oxydant métaboliques et d’en comprendre certains mécanismes liés à l’absorption intestinale et la réactivité du 4-HHE. D’une part, notre étude a confirmé que la consommation d’AGPI-LC n-3 empêche l’induction du stress oxydant et de l’inflammation lors d’un régime hyperlipidique chez la souris. Cependant, par rapport aux TG, les PL vecteurs d’AGPI n-3 permettent de réduire la taille des adipocytes et de stimuler le système antioxydant. D’autre part, notre étude a montré que la consommation d’AGPI n-3 oxydés de manière modérée aboutit à une élévation des concentrations plasmatiques de 4-HHE et des marqueurs inflammatoires. De plus, une activation des voies inflammatoires ainsi que du stress du réticulum endoplasmique ont été détectées au niveau de l’intestin grêle. Nos résultats in vivo et in vitro sur cellules intestinales Caco-2/TC7 indiquent que cela peut être dû en partie à une absorption au niveau intestinal du 4-HHE, produit d’oxydations des AGPI n-3. Dans le contexte du développement des aliments contenant des AGPI-LC n-3, nos résultats contribuent à identifier les structures vectrices de ces acides gras les plus efficaces du point de vue métabolique. En santé publique et en pratique clinique, nos résultats constituent une nouvelle base de réflexion pour la mise en place de bonnes pratiques de production et de conservation des aliments et des compléments nutritionnels enrichis en AGPI-LC n-3 pour éviter leur oxydation et ses possibles effets délétères
Dietary intake of n-3 long chain (LC) polyunsaturated fatty acids (PUFA) are recommended for their beneficial effects on human health, especially to prevent the development of metabolic diseases. However, the bioavailability of these PUFAs and their metabolic impact could be modulated by their chemical carriers (triacylglycerols, TG or phospholipids, PL). In addition, these PUFA are susceptible to lipid peroxidation. If they are not protected from oxidation, they can form toxic reactive species such as 4-hydroxy-hexenal (4-HHE). In this context, the aim of our study was to evaluate the impact of enriching high-fat diets with n-3 PUFA (i) bound to TG or PL and (ii) in unoxidized or oxidized form on the generation of inflammation and oxidative stress, and to understand some underlying mechanisms associated with intestinal absorption and reactivity of 4-HHE. On the one hand, our study confirmed in mice that the consumption of n-3 PUFA protects against oxidative stress and inflammation induced by high-fat diets. However, compared to TG, n-3 PUFA in the form of PL reduce the size of adipocytes and stimulate the antioxidant system. On the other hand, our study showed that the consumption of moderately oxidized n-3 PUFA results in increased plasma concentrations of 4-HHE and of inflammatory markers. In addition, activation of inflammatory pathways as well as endoplasmic reticulum stress were detected in the small intestine. Our results in vivo and in vitro, using intestinal Caco-2/TC7 cells, indicate that this can be partly due to the intestinal absorption of the end-product of n-3 PUFA oxidation, 4-HHE. In the context of the development of foods containing LC n-3 PUFA, our results contribute to identify the most effective PUFA carriers on a metabolic standpoint. Regarding public health and clinical practice, our results provide new basis for the set up of best practices regarding production and storage of food and supplements enriched with LC n-3 PUFA to avoid their lipid oxidation and its possible deleterious effects
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Liu, Hong-yi, und 劉鴻毅. „Study on the roles and quantification of 3-hydroxy fatty acids in the soma and supernatant of cultured Burkholderia cepacia complex“. Thesis, 2009. http://ndltd.ncl.edu.tw/handle/78dh4t.

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碩士
國立高雄師範大學
生物科學研究所
97
Study on the roles and quantification of 3-hydroxy fatty acids in the soma and supernatant of cultured Burkholderia cepacia complex Abstract Although Burkholderia cepacia complex (BCC) divided into 9 of recA genomovars in present, the virulence to hosts in these genomovars were still undifferentiated. We hypothesized that, in cultural supernatants, the amounts of C14:0 3-OH fatty acids, the unique components of BCC lipopolysaccharides (LPS), acted as a biomarker for virulence, were related to the degrees of pathologically inflammatory effects on animals with BCC infection. Thirty-two strains were identified to BCC gonomorvarⅢa by the outcomes of biochemical and molecular tests, and typed to their genetic independence by the profiles of cellular fatty acid and randomly amplified polymorphic DNA (RAPD), respectively. To determine the concentration of fatty acids in supernatants, the quantitative profiles of each fatty acid methyl ester (FAME) analyzed by gas chromatography mass spectrometry (GC/MS) was developed. In this study, the instrument detection limits were reached to 26 ng/ml. The optimal reaction was defined as >90% in esterification for each fatty acid. The processing of samples were performed as that, after a 7 d-incubation, the cultural supernatants were acted as reactants and sequentially reacted to alkaline hydrolysis for 30 min and esterification for 10min. Among of the cultures of these isolates, the concentration of C14:0 3-OH fatty acid in supernatants was ranged from 19.3±0.4 to 133.7±3.6ng/ml. The molar ratio of C14:0/C16:0 3-OH fatty acid was calculated to be 1.78±0.3. With multiple regression analysis, a positive correlation was shown that the concentration of 3-OH fatty acids in supernatants of each isolates was against some levels of pathological effect (area of cell debris in liver) of Balb/c mice with tested BCC infection individually (R2=0.682). Results suggested that the concentration of C14:0 3-OH fatty acid in BCC cultural supernatants was acted as an indicator of virulence to the mice with the bacterial infection for 2 d. Keywords：Burkholderia cepacia complex, lipopolysaccharides, C14:0 3-OH fatty acid, Gas chromatography mass spectrometry
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Buchteile zum Thema "3-hydroxy fatty acids"

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Kock, J. Lodewyk F., Pierre Venter, Alfred Botha, Dennis J. Coetzee, Pieter W. J. van Wyk, Dandré P. Smith, Tankred Schewe und Santosh Nigam. „Production of 3-Hydroxy Fatty Acids by the Yeast Dipodascopsis Uninucleata. Biological Implications“. In Advances in Experimental Medicine and Biology, 675–77. Boston, MA: Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4793-8_97.

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Raulin, J., D. Lapous, C. Loriette und I. K. Grundt. „HMGR (3-Hydroxy, 3-Methylglutaryl-CoA Reductase) Activity of Cultured Rat Brain Cells: Sensitivity to n-3 and n-6 Polyunsaturated Fatty Acids (PUFAs) from Cod-Liver and Sunflower Oils“. In Enzymes of Lipid Metabolism II, 479–84. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-5212-9_62.

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Ziboh, Vincent A. „Cutaneous essential fatty acids and hydroxy fatty acids: Modulation of inflammatory and hyperproliferative processes“. In Fatty Acids and Inflammatory Skin Diseases, 55–67. Basel: Birkhäuser Basel, 1999. http://dx.doi.org/10.1007/978-3-0348-8761-8_4.

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Cullingford, T. E., K. K. Bhakoo, S. Peuchen, C. T. Dolphin und J. B. Clark. „Regulation of the Ketogenic Enzyme Mitochondrial 3-Hydroxy-3-Methylglutaryl-COA Synthase in Astrocytes and Meningeal Fibroblasts“. In Current Views of Fatty Acid Oxidation and Ketogenesis, 241–51. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/0-306-46818-2_29.

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Jones, Patricia M., und Michael J. Bennett. „3-Hydroxy-Fatty Acid Analysis by Gas Chromatography-Mass Spectrometry“. In Methods in Molecular Biology, 229–43. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60761-459-3_21.

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Derogis, Priscilla Bento Matos Cruz, Adriano B. Chaves-Fillho und Sayuri Miyamoto. „Characterization of Hydroxy and Hydroperoxy Polyunsaturated Fatty Acids by Mass Spectrometry“. In Advances in Experimental Medicine and Biology, 21–35. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-11488-6_2.

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Tanamoto, K. „Development of a New Quantitative Method for Detection of Endotoxin by Fluorescence Labeling of 3-Hydroxy Fatty Acid“. In Endotoxin, 203–13. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4757-5140-6_18.

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Aitken, Alastair. „Structure determination of acylated proteins“. In Lipid Modification of Proteins, 63–88. Oxford University PressOxford, 1992. http://dx.doi.org/10.1093/oso/9780199632749.003.0004.

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Abstract This chapter will describe methods available for the study of the modifications in the wide range of eukaryotic and prokaryotic proteins known to be acylated with fatty acids. There are three main types of such modification in eukaryotes: at the amino terminus on glycine residues (1); internally attached to cysteine or hydroxy-amino acids (2); or at the carboxy-terminus as a PI containing glycan moiety (3) (see Figure 1). Analysis of isoprenylation (4) at the carboxy-terminus will also be covered. The methods described will be confined to those not included in other chapters of this volume.
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Konferenzberichte zum Thema "3-hydroxy fatty acids"

1

Véquaud, P., S. Derenne, A. Thibault, C. Anquetil, G. Bonanomi, S. Collin, S. Contreras et al. „Global Temperature and pH Calibrations Based on Bacterial 3-HYDROXY Fatty Acids in Soils“. In 30th International Meeting on Organic Geochemistry (IMOG 2021). European Association of Geoscientists & Engineers, 2021. http://dx.doi.org/10.3997/2214-4609.202134047.

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Hou, C., G. Duffy, A. Yamoah, D. Sasche, P. Chaiseanwang, C. Wang, Y. Yang, E. Norris und J. Bendle. „Initial Calibration of 3-Hydroxy Fatty Acids Paleoclimate Proxies for European Lakes and Soils“. In IMOG 2023. European Association of Geoscientists & Engineers, 2023. http://dx.doi.org/10.3997/2214-4609.202333062.

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Véquaud, P., S. Collin, C. Anquetil, J. Poulenard, P. Sabatier, P. Choler, S. Derenne und A. Huguet. „Bacterial 3-Hydroxy Fatty Acids: Applicability as Temperature and Ph Proxies in Soils from the French Alps“. In 29th International Meeting on Organic Geochemistry. European Association of Geoscientists & Engineers, 2019. http://dx.doi.org/10.3997/2214-4609.201902985.

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Naeher, S., S. Rosenberg, J. A. Bendle, K. Yamoah, J. Pearman, B. Duncan und M. J. Vandergoes. „Investigating Bacterial 3-Hydroxy Fatty Acids as New Indicators of Past Air Temperature in Lake Sediments from New Zealand“. In IMOG 2023. European Association of Geoscientists & Engineers, 2023. http://dx.doi.org/10.3997/2214-4609.202333039.

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Huguet, Arnaud, Eve Hellequin, Pierre Véquaud, Marina Seder-Colomina, Sylvie Collin und Adrienne Kish. „Effect of temperature and pH on the membrane lipid composition of soil Gram-negative bacteria isolates: Implications for the use of 3-hydroxy fatty acids as (paleo)environmental proxies“. In Goldschmidt2023. France: European Association of Geochemistry, 2023. http://dx.doi.org/10.7185/gold2023.16169.

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Wang, Canfa, James Bendle, Huan Yang, Yi Yang, Alice Hardman, Afrifa Yamoah, Amy Thorpe et al. „Calibration of bacterial 3-hydroxy fatty acid based palaeoclimate proxies in global soils“. In Goldschmidt2021. France: European Association of Geochemistry, 2021. http://dx.doi.org/10.7185/gold2021.7290.

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Hardman, A., A. Thorpe, K. Yamoah, C. Wang, Y. Yang, D. Read und J. Bendle. „A Novel 3-Hydroxy Fatty Acid-Based Palaeothermometer Developed from Southwestern US Lacustrine Environments“. In IMOG 2023. European Association of Geoscientists & Engineers, 2023. http://dx.doi.org/10.3997/2214-4609.202333161.

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Bendle, J., C. Wang, Y. Yang, A. Hardman, A. Yamoah, A. Thorpe, I. Mandel et al. „Calibration of Bacterial 3-Hydroxy Fatty Acid-Based Paleoclimate Proxies in Global Soils, Marine Sediments and Lakes“. In 30th International Meeting on Organic Geochemistry (IMOG 2021). European Association of Geoscientists & Engineers, 2021. http://dx.doi.org/10.3997/2214-4609.202134241.

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Hines, C. J., M. Petersen, M. Mendell, D. Milton, L. Larsson und W. Fisk. „146. Endotoxin and 3-Hydroxy Fatty Acid Analysis of Air and Dust Samples from an Office Building“. In AIHce 1998. AIHA, 1999. http://dx.doi.org/10.3320/1.2762528.

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Dalli, Jesmond, Ana Rodriguez, Bernd Spur und Charles Serhan. „Structure elucidation and biological evaluations of sulfido-conjugated specialized pro-resolving mediators“. In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/mqgv6628.

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Inflammatory diseases are characterized by unabated inflammation that leads tissue destruction resulting in malaise. Whilst much is known on the mechanism that perpetuate inflammation, less is known about the molecules and pathways that coordinate the termination of inflammation and facilitate the repair and regeneration of damaged tissues. To evaluate the potential contribution of essential fatty acid-derived mediators in coordinating this life saving response we interrogated inflammatory exudates obtained following self-limited inflammatory challenge. Using radio-isotope tracking we found that the omega-3 fatty acid docosahexaenoic acid is utilized to produce novel bioactive molecules in these exudates. The structures of these molecules were elucidated using a range of physical techniques, demonstrating that these molecules were peptide lipid conjugated mediators and the stereochemistry of the functional groups was established using total organic synthesis. Investigations into their biosynthetic pathways demonstrated that the formation of their formation was initiated via the 14-lipoxygenation of DHA, that was then converted into an intermediate allylic epoxide and then conjugated to glutathione to yield the first mediator in the family which was coined as maresin conjugated in tissue regeneration (MCTR)1. This was then further converted to to 13-cysteinylglycinyl,14-hydroxy-docosahexaenoic acid (MCTR2) and 13-glycinyl,14-hydroxy-docosahexaenoic acid (MCTR3). Evaluation of the biological activities of these molecules demonstrated that they limited the recruitment of inflammatory cells to the sites of both sterile and infectious challenge. They reprogrammed biology towards a tissue protective phenotype and promoted the repair and regeneration of damaged tissues. Evaluation of the levels of these mediators in human peripheral blood demonstrated that the production of MCTR3 is significantly reduced in patients with rheumatoid arthritis that display signs of erosive joint disease. Together, these findings identify previously undescribed chemical signals that enhance host responses to limit inflammation, stimulate resolution of inflammation, and promote the restoration of function.
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