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Медведев, С. С., Д. В. Обливанцева und Д. Н. Небиеридзе. „Анализ женской преступности и выявление ее причин“. ТЕНДЕНЦИИ РАЗВИТИЯ НАУКИ И ОБРАЗОВАНИЯ 74, Nr. 6 (2021): 110–12. http://dx.doi.org/10.18411/lj-06-2021-227.
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В данной статье проведен правовой анализ женской преступности, направленный на выявление ее причин. Актуальность исследования в том, что лица женского пола все чаще стали прибегать к совершению преступлений. Особенностью женской преступности является то, что она в сравнении с мужской преступностью носит не такой массовый характер, но с каждым годом количественные показатели, согласно статистическим данным, имеют тенденцию роста. И это несмотря на то, что в нашей стране женщин больше, чем мужчин. Безусловно, данная тема актуальна в настоящее время. Результаты данного исследования позволяют углубить познания.
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O'Dea, Denise, Catherine M. Handy und Ann Wexler. „Ocular Changes With Oxaliplatin“. Clinical Journal of Oncology Nursing 10, Nr. 2 (01.04.2006): 227–29. http://dx.doi.org/10.1188/06.cjon.227-229.
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Шарко, Ю. И., und А. Ю. Иокамиди. „Северный морской путь. перспективы развития универсального транспортного коридора“. ТЕНДЕНЦИИ РАЗВИТИЯ НАУКИ И ОБРАЗОВАНИЯ 98, Nr. 4 (2023): 157–61. http://dx.doi.org/10.18411/trnio-06-2023-227.
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В данной статье проведен анализ перспектив инфраструктурного развития Арктики в условиях глобального изменения климата. Потепление способствует сокращению площади льда в летний период, что в свою очередь открывает новые возможности, для развития Арктической зоны с ее огромным потенциалом. Россия должна стремиться к максимально эффективному использованию северных территорий. Данное исследование актуально, в связи с развитием Северного морского пути, и превращением его в инфраструктурный транспортный объект. Сокращение ледяного покрова означает новые экономические возможности, а именно: рыболовные угодья, судоходные маршруты, доступ к скрытым месторождениям нефти и газа. В нынешних политических и экономических условиях требуются глобальные изменения в управлении транспортной системы Арктического региона. Поисков новых механизмов взаимодействия и сотрудничества с иностранными государствами, а также привлечение частного финансирования
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Ситянина, Н. В. „Лексические единицы, обозначающие уникальность товара и его положительные качества как средство воздействия в рекламе продуктов питания“. ТЕНДЕНЦИИ РАЗВИТИЯ НАУКИ И ОБРАЗОВАНИЯ 86, Nr. 5 (2022): 120–23. http://dx.doi.org/10.18411/trnio-06-2022-227.
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В статье рассматривается эмоционально-экспрессивная лексика как средство привлечения внимания в рекламных текстах продуктов питания. Изучению подвергается самая многочисленная группа лексических единиц, обозначающих положительные свойства и уникальность товара. Автор анализирует особенности данных лексических единиц и их функционирование в русскоязычных и англоязычных рекламных текстах.
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Shrestha, Abhigan Babu, Manjil Aryal und Sajina Shrestha. „Masking of Possible Dengue Epidemic Due to COVID-19 Pandemic in Nepal“. International Journal of Human and Health Sciences (IJHHS) 6, Nr. 2 (31.03.2022): 227. http://dx.doi.org/10.31344/ijhhs.v6i2.452.
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COVID-19 had its first outbreak in Wuhan city, China. With its escalating cases, WHO declared it as a pandemic on 11th of March, 2020. Nepal faced the same scenario as other countries. Being a landlocked country, India facing its possible third wave has created a greater concern for Nepal. Along with COVID-19 cases, dengue cases have also been spotted. Nepal is a dengue endemic country with the worst endemic faced in 2019. COVID-19 and dengue share similar clinical and diagnostic features. As of now, all focus is given to control the pandemic, with minimal attention to dengue. This monsoon season, dengue cases are anticipated to increase so, proper attention must be driven towards it. Preparations must be taken to tackle the endemic. Vector surveillance programs and mass awareness should be done, focusing on previous endemic zones. Places lacking rapid diagnostic tests must be supplied with it as soon as possible in order to prevent the untimely diagnosis of dengue or even co-infection which could be more lethal cocktail.International Journal of Human and Health Sciences Vol. 06 No. 02 April’22 Page: 227-230
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Mozgunov, Evgeny, und Daniel Lidar. „Completely positive master equation for arbitrary driving and small level spacing“. Quantum 4 (06.02.2020): 227. http://dx.doi.org/10.22331/q-2020-02-06-227.
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Markovian master equations are a ubiquitous tool in the study of open quantum systems, but deriving them from first principles involves a series of compromises. On the one hand, the Redfield equation is valid for fast environments (whose correlation function decays much faster than the system relaxation time) regardless of the relative strength of the coupling to the system Hamiltonian, but is notoriously non-completely-positive. On the other hand, the Davies equation preserves complete positivity but is valid only in the ultra-weak coupling limit and for systems with a finite level spacing, which makes it incompatible with arbitrarily fast time-dependent driving. Here we show that a recently derived Markovian coarse-grained master equation (CGME), already known to be completely positive, has a much expanded range of applicability compared to the Davies equation, and moreover, is locally generated and can be generalized to accommodate arbitrarily fast driving. This generalization, which we refer to as the time-dependent CGME, is thus suitable for the analysis of fast operations in gate-model quantum computing, such as quantum error correction and dynamical decoupling. Our derivation proceeds directly from the Redfield equation and allows us to place rigorous error bounds on all three equations: Redfield, Davies, and coarse-grained. Our main result is thus a completely positive Markovian master equation that is a controlled approximation to the true evolution for any time-dependence of the system Hamiltonian, and works for systems with arbitrarily small level spacing. We illustrate this with an analysis showing that dynamical decoupling can extend coherence times even in a strictly Markovian setting.
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Caioni, Charles, Sandra Mara Alves da Silva Neves, Santino Seabra Junior und Ronaldo José Neves. „ANÁLISE MULTITEMPORAL DA TEMPERATURA SUPERFICIAL DO MUNICÍPIO DE CARLINDA - MATO GROSSO“. Boletim de Geografia 35, Nr. 3 (08.09.2017): 26. http://dx.doi.org/10.4025/bolgeogr.v35i3.27779.
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O bioma Amazônia por meio do processo de interação solo, planta e atmosfera desempenha importante papel na regulação do clima, contudo os diferentes usos antrópicos vêm ocasionando significativas alterações no balanço do fluxo energético superficial, que podem implicar em fortes mudanças de temperatura e umidade do solo. O presente estudo objetivou realizar a análise multitemporal da temperatura superficial do município de Carlinda/Mato Grosso, bem como, verificar sua relação com os índices de uso da terra e de vegetação por Diferença Normaliza. Para a elaboração dos mapas temáticos utilizou-se três imagens do satélite Landsat 5 (08/08/1994, 28/06/2004 e 13/06/2010), todas referentes a órbita/ponto 227/67. As imagens foram georreferenciadas, recortadas, segmentadas e classificadas no software SPRING 4.3. Os layouts e as quantificações foram feitas no software Arcgis 9.2. Os índices de vegetação por Diferença Normalizada foram obtidos a partir das bandas 3 e 4, do sensor TM, referentes as faixas do infravermelho médio e do infravermelho próximo, respectivamente. Para a obtenção dos níveis térmicos realizou-se a conversão na banda 6 dos números digitais em temperatura. Os resultados indicaram relações entre os valores de índices de vegetação por Diferença Normalizada, uso da terra e temperatura superficial, verificando as menores temperaturas para os ambientes hídricos e florestais e as maiores para as áreas de pastagem degradada, urbana e de solo exposto. Constatou-se ainda aumentos dos níveis térmicos superficiais, que podem vir a causar fortes reduções de disponibilidade hídrica ao município. Concluiu-se que o aumento do uso antrópico e a redução do vigor da vegetação, que implica no decréscimo dos valores dos índices de vegetação, têm sido as principais causas da elevação dos níveis térmicos superficiais, necessitando da tomada de medidas mitigadoras de controle para reversão deste cenário.
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Mota, Jose Mauricio S. C., Min Yuen Teo, Andrea Knezevic, Richard Martin Bambury, Vaios Hatzoglou, Karen A. Autio, Wassim Abida et al. „Clinicopathologic and genomic characterization of parenchymal brain metastases (BM) in prostate cancer (PCa).“ Journal of Clinical Oncology 37, Nr. 7_suppl (01.03.2019): 227. http://dx.doi.org/10.1200/jco.2019.37.7_suppl.227.
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227 Background: BM are rarely seen with PCa, but the incidence may be increasing with contemporary therapies. We sought to evaluate the clinical phenotypes associated with BM and their outcomes. Methods: The MSKCC institutional clinical database from 01/2001 through 06/2018 was reviewed to identify pts with PCa and (1) secondary malignant neoplasm of the brain / spinal cord per ICD-9 (198.3), (2) radiation treatment plan targeting the brain, (3) craniotomy, or (3) notes containing the terms “brain metastasis”. Medical charts were reviewed to confirm diagnosis (dx) and extract data. The logrank statistic and the Cox proportional hazards model were used to determine correlations with overall survival (OS). Results: Of 575 pts who met search criteria, 43 had BM and prostate adenocarcinoma. At PCa dx, median age was 60 years (range: 44 –77 years) and 51% had metastasis (mets). Median time from PCa dx to BM was 4.2 years. At the time of BM dx, 36 had metastatic castration-resistant PCa (mCRPC), 55% had liver mets and 66% had lung mets. 45% had ≥3 lines of therapy for mCRPC prior to BM dx (abiraterone/enzalutamide: 47%, chemotherapy: 91%). The median OS from BM dx was 5.8 months (Table). 4/10 pts with sequencing data had germline mutations ( ATM, BRCA1, BRIP1, MUTYH). To date, 4 BM were sequenced, and 3 showed PTEN loss. Conclusions: BM associated with a poor prognosis and occurred after prolonged treatment. Presence of liver/lung mets, 3 or more BM, and surgical resection (SR) prognosticate for OS in univariate analysis; SR in multivariate analysis. Further analysis is needed to determine if germline mutations and/or PTEN loss associate with BM. [Table: see text]
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Lan, Phạm Thị, und Huỳnh Minh Tuấn. „Chi phí chăm sóc y tế các nhiễm khuẩn đa kháng tại Bệnh viện Đại học Y Dược Thành Phố Hồ Chí Minh“. Tạp chí Y học Dự phòng 32, Nr. 4 Phụ bản (27.06.2022): 58–64. http://dx.doi.org/10.51403/0868-2836/2022/719.
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Nghiên cứu mô tả hồi cứu nhằm xác định chi phí chăm sóc y tế các nhiễm khuẩn đa kháng tại Bệnh viện Đại học Y Dược Thành Phố Hồ Chí Minh từ 06/2018 đến 09/2019. Đối tượng tham gia là người bệnh ICU nhiễm MRSA hoặc CRE và người bệnh không có vi khuẩn đa kháng thuốc như một nhóm được so sánh. Kết quả có 227 người bệnh, với 37 người bệnh nhiễm MRSA, 97 người bệnh nhiễm CRE và 93 người bệnh không nhiễm Multidrug - resistant organisms (MDRO), đã được tuyển chọn. Chi phí trung bình tăng thêm cho một đợt điều trị của một ca nhiễm khuẩn CRE (367,7 triệu đồng) và cho một ca nhiễm MRSA (139,1 triệu đồng) cao hơn 3,8 lần (p < 0,001) và cao hơn 1,5 lần (p < 0,001), tương ứng, so với chi phí trung bình cho một trường hợp không nhiễm MDRO (94,8 triệu đồng). Trong nhóm nhiễm MDRO, nguồn lực cho mỗi đợt nhiễm CRE cao hơn so với trường hợp MRSA, với ngày điều trị kháng sinh dài hơn (tăng 13,4 ngày) và thời gian nằm viện (LOS) lớn hơn (tăng 15,8 ngày) và chi phí cao hơn (tăng 228,6 triệu đồng). Nghiên cứu cho thấy nhiễm khuẩn đa kháng thuốc tạo ra gánh nặng kinh tế nặng nề cho quốc gia có thu nhập trung bình thấp như Việt Nam. Chi phí tăng chủ yếu do điều trị kháng sinh lâu hơn và tăng LOS.
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Afroz, Shireen, Tahmina Ferdous, Tania Sharmin und Nasir Hossain. „Aetiology and outcome of Hypernatremia in Post Diarrhoeal Acute Kidney Injury in Children An Experience in Dhaka Medical College Hospital“. Northern International Medical College Journal 8, Nr. 2 (14.05.2017): 224–27. http://dx.doi.org/10.3329/nimcj.v8i2.32555.
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Background : Hypernatremia (serum sodium 150mmol/L) is one of the most life-threatening complications of childhood diarrhoea, Acute kidney injury(AKI) when associated with hypernatremia results increased mortality and long term morbidity.Objectives : Our objective was to find out the aetiology and outcome of hypernatremia in post diarrhoeal AKI in children in a teaching hospital in Bangladesh.Methods : This prospective observational study was conducted over 06 months in the Paediatric Nephrology Department of Dhaka Medical College Hospital. A total of 15 children withpost diarrhoeal AKI withhypernatremia were evaluated.AKI staging was done by pRIFLE criteria. Hypernatremia was classified into mild, moderate and severe gradings. All patients were treated conservatively and with Intermittent Peritoneal Dialysis (IPD) as needed. Fluid adjustment was done according to serum sodium level.At the end of the study, samples were divided in to survive and death groups depending on outcome.Results : Age of the children ranged from 2 months to 18months. Ninety three percent cases were under 1 year.Forty seven percent patients were in Failure stage of AKI, 47%in Injury and 1 patient in Risk stage.Out of 15 cases 93% had severe hypernatremia. In 67% casesthe causes of hypernatremia were intake of concentrated oral rehydration solution (ORS) and found more in winter season. Regardless of cause overall 47% survived with normal renal functions and 53% died.Conclusion : Intake of concentrated ORS and diarrhoea during winter seasona are the most important cause of hypernatremia in infancy. Hypernatremia with AKI stage III (Failure) had poorest outcome.Northern International Medical College Journal Vol.8(2) January 2017: 224-227
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Sharmin, Saida, Zobayed Sultan und Kazi Mahbubul Haque. „Socio-Economic Status and Health Seeking Behaviour Among the People of Rural Areas of Pangsha Upazila ofRajbari District, Bangladesh“. International Journal of Human and Health Sciences (IJHHS) 6, Nr. 2 (31.03.2022): 188. http://dx.doi.org/10.31344/ijhhs.v6i2.444.
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Background: Health seeking behaviour is an important factor in health management. Socioeconomic status is having greater impact on health care utilization especially in developing countries.Objective: To identify the socioeconomic factors of rural community people and their health care seeking behaviour.Methods: The descriptive, cross-sectional study was conducted in Pangsha upazila of Rajbari district in Bangladesh, between January 2018 and February 2018. A total of 317 purposively selected people were interviewed face to face using a pre-tested semi-structured questionnaire.Results: In this study, majority 98 (30.91%) of the respondents were within the age group of below 31 years (41.47±15.12). More than two-thirdsi.e. 218 (68.76%) of the respondent was male and majority 205 (64.50%) belonged to nuclear family. Most of the respondents were married 283 (89.00%) and 227 (71.40%) of the respondents were Muslim. Majority 149 (47.00%) of the respondents’ monthly income was between 10000 and 20000 Bangladeshi Taka. Among all respondents, majority 60 (18.92%) people sought treatment for fever. 193 (60.89%) used to visit private health facility. 181 (56.9%) people took treatment by MBBS doctor and 205 (64.50%) of the respondents choose the specific health facility for the reason of better treatment.Conclusion: Health seeking behaviour of people in this study was appreciable. In this study, people received treatment from private health facility. The perception of the people has to be changed to attract them more to government hospitals. It can be done through improving the quality of care, proper maintenance of facilities.Awareness raising activities, and education for health behaviour change are also recommended.International Journal of Human and Health Sciences Vol. 06 No. 02 April’22 Page: 188-192
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Payne, Martha E., Douglas R. McQuoid, David C. Steffens und John J. B. Anderson. „Elevated brain lesion volumes in older adults who use calcium supplements: a cross-sectional clinical observational study“. British Journal of Nutrition 112, Nr. 2 (01.05.2014): 220–27. http://dx.doi.org/10.1017/s0007114514000828.
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Recent studies have implicated Ca supplements in vascular risk elevation, and therefore these supplements may also be associated with the occurrence of brain lesions (or hyperintensities) in older adults. These lesions represent damage to brain tissue that is caused by ischaemia. In the present cross-sectional clinical observational study, the association between Ca-containing dietary supplement use and lesion volumes was investigated in a sample of 227 older adults (60 years and above). Food and supplemental Ca intakes were assessed with the Block 1998 FFQ; participants with supplemental Ca intake above zero were categorised as supplement users. Lesion volumes were determined from cranial MRI (1·5 tesla) scans using a semi-automated technique; volumes were log-transformed because they were non-normal. ANCOVA models revealed that supplement users had greater lesion volumes than non-users, even after controlling for food Ca intake, age, sex, race, years of education, energy intake, depression and hypertension (Ca supplement use: β = 0·34, se 0·10, F1,217= 10·98, P= 0·0011). The influence of supplemental Ca use on lesion volume was of a magnitude similar to that of the influence of hypertension, a well-established risk factor for lesions. Among the supplement users, the amount of supplemental Ca was not associated with lesion volume (β = − 0·000035, se 0·00 015, F1,139= 0·06, P= 0·81). The present study demonstrates that the use of Ca-containing dietary supplements, even low-dose supplements, by older adults may be associated with greater lesion volumes. Evaluation of randomised controlled trials is warranted to determine whether this relationship is a causal one.
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Groeneveld, Johanna M., Aranka V. Ballering, Kees van Boven, Reinier P. Akkermans, Tim C. Olde Hartman und Annemarie A. Uijen. „Sex differences in incidence of respiratory symptoms and management by general practitioners“. Family Practice 37, Nr. 5 (30.05.2020): 631–36. http://dx.doi.org/10.1093/fampra/cmaa040.
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Abstract Background Differences between women and men play an important role in lung physiology and epidemiology of respiratory diseases, but also in the health care processes. Objective To analyse sex differences in patients encountering their general practitioner (GP) with respiratory symptoms with regard to incidence, GP’s management and final diagnoses. Methods Retrospective cohort study, using data of the Dutch Practice Based Research Network. All patients who encountered their GP from 01-07-2013 until 30-06-2018 with a new episode of care starting with a reason for encounter in the respiratory category (R) of the ICPC-2 classification were included (n = 16 773). Multi-level logistic regression was used to analyse influence of patients’ sex on management of GPs with adjustment for possible confounders. Results We found a significant higher incidence of respiratory symptoms in women than in men: 230/1000 patient years [95% confidence interval (CI) 227–232] and 186/1000 patient years (95% CI 183–189), respectively. When presenting with cough, GPs are more likely to perform physical examination [odds ratio (OR) 1.22; 95% CI 1.11–1.35] and diagnostic radiology (OR 1.25; 95% CI 1.08–1.44), but less likely to prescribe medication (OR 0.88; 95% CI 0.82–0.95) in men. When visiting the GP with dyspnoea, men more often undergo diagnostic imaging (OR 1.32; 95% CI 1.05–1.66) and are more often referred to a specialist (OR 1.35; 95% CI 1.13–1.62). Conclusions Women encounter their GP more frequently with respiratory symptoms than men and GPs perform more diagnostic investigations in men. We suggest more research in general practice focussing on sex differences and possible confounders.
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Zietman, Anthony L., Kyounghwa Bae, Jerry D. Slater, William U. Shipley, Jason A. Efstathiou, John J. Coen, David A. Bush et al. „Randomized Trial Comparing Conventional-Dose With High-Dose Conformal Radiation Therapy in Early-Stage Adenocarcinoma of the Prostate: Long-Term Results From Proton Radiation Oncology Group/American College of Radiology 95-09“. Journal of Clinical Oncology 28, Nr. 7 (01.03.2010): 1106–11. http://dx.doi.org/10.1200/jco.2009.25.8475.
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Purpose To test the hypothesis that increasing radiation dose delivered to men with early-stage prostate cancer improves clinical outcomes. Patients and Methods Men with T1b-T2b prostate cancer and prostate-specific antigen ≤ 15 ng/mL were randomly assigned to a total dose of either 70.2 Gray equivalents (GyE; conventional) or 79.2 GyE (high). No patient received androgen suppression therapy with radiation. Local failure (LF), biochemical failure (BF), and overall survival (OS) were outcomes. Results A total of 393 men were randomly assigned, and median follow-up was 8.9 years. Men receiving high-dose radiation therapy were significantly less likely to have LF, with a hazard ratio of 0.57. The 10-year American Society for Therapeutic Radiology and Oncology BF rates were 32.4% for conventional-dose and 16.7% for high-dose radiation therapy (P < .0001). This difference held when only those with low-risk disease (n = 227; 58% of total) were examined: 28.2% for conventional and 7.1% for high dose (P < .0001). There was a strong trend in the same direction for the intermediate-risk patients (n = 144; 37% of total; 42.1% v 30.4%, P = .06). Eleven percent of patients subsequently required androgen deprivation for recurrence after conventional dose compared with 6% after high dose (P = .047). There remains no difference in OS rates between the treatment arms (78.4% v 83.4%; P = .41). Two percent of patients in both arms experienced late grade ≥ 3 genitourinary toxicity, and 1% of patients in the high-dose arm experienced late grade ≥ 3 GI toxicity. Conclusion This randomized controlled trial shows superior long-term cancer control for men with localized prostate cancer receiving high-dose versus conventional-dose radiation. This was achieved without an increase in grade ≥ 3 late urinary or rectal morbidity.
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Severyns, Mathieu, Renault Arthur und Stéphane Plawecki. „Meniscal tears and entrapment in intercondylar eminence fractures in children: a systematic review of the literature“. Orthopaedic Journal of Sports Medicine 10, Nr. 3_suppl (01.03.2022): 2325967121S0037. http://dx.doi.org/10.1177/2325967121s00371.
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Objectives: Although they may be related to ACL tears in adults, there are few publications on meniscal injuries after intercondylar eminence fractures in children. Methods: The main objective of this systematic review of the literature was to measure the incidence of meniscal injuries as well as concomitant tissue involvement in tibial eminence fractures (TEF) in children. The secondary objectives were to determine a diagnostic and therapeutic strategy to anticipate difficulties in reduction and to treat associated meniscal tears. The PubMed and Scopus database subject search included MeSH indexing terms: "intercondylar tibial fracture*" OR "tibial spine fracture*" OR “tibial spinal fracture” OR "tibial eminence fracture*" OR "intercondylar eminence fracture*". Only series of pediatric tibial eminence fractures with the presence of data on possible meniscal damage were selected. Case reports, mixed adult and child series and duplicates were excluded. Results: 789 references were chosen with 91 eligible articles. Only 26 articles reported on the rates of meniscal tears and entrapment after these fractures. Of a total of 997 cases, 227 (22.8%) had a concomitant injury (osteochondral, ACL, PCL and/or meniscal), including 180 cases of meniscal tears (18.1%). Meniscal or intermeniscal ligament entrapment was present in 20.1% (n = 201) of the patients. 2 groups of diagnostic analyses of these injuries were compared: during the arthroscopy, or previously on MRI imaging. Meniscal tears were present in 20.9% of the patients in the arthroscopy group, compared with 26.1% in the group with a prior MRI (p = .06), and the proportion of meniscal tears was 18.6% in the arthroscopy group alone compared to 17.1% in the MRI group (p = .55). However, statistically, the proportion of entrapment noted was significantly higher in the arthroscopy group (17.8% vs 6.2%; p <.0001). Conclusion: This review of the literature reports a high incidence of meniscal tears and tissue entrapment in children. Although it would appear that MRI tends to improve the assessment of associated injuries, the rate of meniscal or intermeniscal ligament entrapment is low compared to the rate reported by arthroscopic diagnosis.
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Brouwer-Brolsma, Elske M., Diewertje Sluik, Cecile M. Singh-Povel und Edith J. M. Feskens. „Dairy product consumption is associated with pre-diabetes and newly diagnosed type 2 diabetes in the Lifelines Cohort Study“. British Journal of Nutrition 119, Nr. 4 (28.02.2018): 442–55. http://dx.doi.org/10.1017/s0007114517003762.
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AbstractPrevious studies show associations between dairy product consumption and type 2 diabetes, but only a few studies conducted detailed analyses for a variety of dairy subgroups. Therefore, we examined cross-sectional associations of a broad variety of dairy subgroups with pre-diabetes and newly diagnosed type 2 diabetes (ND-T2DM) among Dutch adults. In total, 112 086 adults without diabetes completed a semi-quantitative FFQ and donated blood. Pre-diabetes was defined as fasting plasma glucose (FPG) between 5·6 and 6·9 mmol/l or HbA1c% of 5·7–6·4 %. ND-T2DM was defined as FPG ≥7·0 mmol/l or HbA1c ≥6·5 %. Logistic regression analyses were conducted by 100 g or serving increase and dairy tertiles (T1ref), while adjusting for demographic, lifestyle and dietary covariates. Median dairy product intake was 324 (interquartile range 227) g/d; 25 549 (23 %) participants had pre-diabetes; and 1305 (1 %) had ND-T2DM. After full adjustment, inverse associations were observed of skimmed dairy (OR100 g 0·98; 95 % CI 0·97, 1·00), fermented dairy (OR100 g 0·98; 95 % CI 0·97, 0·99) and buttermilk (OR150 g 0·97; 95 % CI 0·94, 1·00) with pre-diabetes. Positive associations were observed for full-fat dairy (OR100 g 1·003; 95 % CI 1·01, 1·06), non-fermented dairy products (OR100 g 1·01; 95 % CI 1·00, 1·02) and custard (ORserving/150 g 1·13; 95 % CI 1·03, 1·24) with pre-diabetes. Moreover, full-fat dairy products (ORT3 1·16; 95 % CI 0·99, 1·35), non-fermented dairy products (OR100 g 1·05; 95 % CI 1·01, 1·09) and milk (ORserving/150 g 1·08; 95 % CI 1·02, 1·15) were positively associated with ND-T2DM. In conclusion, our data showed inverse associations of skimmed and fermented dairy products with pre-diabetes. Positive associations were observed for full-fat and non-fermented dairy products with pre-diabetes and ND-T2DM.
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McIntosh, Rebecca R., Simon D. Goldsworthy, Peter D. Shaughnessy, Clarence W. Kennedy und Paul Burch. „Estimating pup production in a mammal with an extended and aseasonal breeding season, the Australian sea lion (Neophoca cinerea)“. Wildlife Research 39, Nr. 2 (2012): 137. http://dx.doi.org/10.1071/wr10222.
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Context The Australian sea lion population at Seal Bay Conservation Park, South Australia, was estimated to be declining at a rate of 1.14% per breeding season, on the basis of maximum counts of live pups in each of 13 breeding seasons (Shaughnessy et al. 2006). The reliability of the pup-production estimates used to identify this decline is uncertain. Aims Our aims were to obtain representative and repeatable estimates of pup production and to assess the current rate of decline. Methods We compared four estimates of pup abundance over five breeding seasons (2002–03, 2004, 2005–06, 2007, 2008–09), including the count of cumulative new births, the maximum live-pup count, the number of pups given passive integrated transponder (PIT) tags, and mark–recapture methods using the Petersen estimate. Key results A total of 90% of pup births occurred over a mean of 124 days (s.d. = 14). Final estimates of pup production (from the largest of the four estimation methods used) in the five seasons were 227 (CL 221–239), 288 (CL 273–302), 219 (NA), 260 (CL 254–272) and 268 (CL 268–269). The average estimate of pup mortality was 28.6% (s.d. = 6.3%). The decline in the population at Seal Bay over 17 breeding seasons on the basis of maximum counts of live pups was 0.51% per year or 0.76% per breeding season. However, this trend was not based on best estimates of pup production. On the basis of final estimates for the last five breeding seasons, there is no declining trend. Conclusions The count of cumulative new births was the most reliable measure of pup production; the Petersen mark–recapture estimate provided a check for accuracy and confidence limits about the estimate. Implications The actual rate of change and the expected trajectory of the Seal Bay population remain uncertain. Ongoing monitoring is a priority for this site, using the reliable methods of estimating pup production identified in the present study.
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Ortiz, Johana, John Van Camp, Sylviana Wijaya, Silvana Donoso und Lieven Huybregts. „Determinants of child malnutrition in rural and urban Ecuadorian highlands“. Public Health Nutrition 17, Nr. 9 (30.09.2013): 2122–30. http://dx.doi.org/10.1017/s1368980013002528.
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AbstractObjectiveTo identify and compare the sociodemographic determinants of stunting, wasting and overweight among infants of urban and rural areas in the Ecuadorian highlands.DesignCross-sectional study.SettingNabon (rural) and Cuenca (urban) cantons, Azuay Province, Ecuador.SubjectsA total of 703 children aged 0–24 months and their caregivers (227 rural and 476 urban) recruited during the period from June to September 2008.ResultsStunting prevalence was significantly higher in the rural area (37·4 %v. 17·7 %;P< 0·001) while wasting (7·1 %) and overweight (17·1 %) prevalence were more similar between areas. Determinants of stunting for the pooled sample were male gender (OR = 1·43; 95 % CI 1·06, 1·92;P= 0·02), preterm delivery (OR = 1·65; 95 % CI 1·14, 2·38;P= 0·008), child's age (OR = 1·04; 95 % CI 1·01, 1·07;P= 0·011), maternal education (OR = 0·95; 95 % CI 0·92, 0·99;P= 0·025) and facility-based delivery (OR = 0·57; 95 % CI 0·45, 0·74;P< 0·001). The latter was also a determinant of overweight (OR = 0·39; 95 % CI 0·25, 0·62;P< 0·001). Rural determinants of stunting were maternal height (OR = 0·004; 95 % CI 0·00004, 0·39;P= 0·018), diarrhoea prevalence (OR = 2·18; 95 % CI 1·13, 4·21;P= 0·02), socio-economic status (OR = 0·79; 95 % CI 0·64, 0·98;P= 0·030) and child's age (OR = 1·07; 95 % CI 1·02, 1·11;P= 0·005). Urban determinants were: maternal BMI for stunting (OR = 0·91; 95 % CI 0·84, 0·99;P= 0·027), cough prevalence (OR = 0·57; 95 % CI 0·34, 0·96;P= 0·036) and facility-based delivery (OR = 0·25; 95 % CI 0·09, 0·73;P= 0·011) for overweight, and hygiene for wasting (OR = 0·57; 95 % CI 0·36, 0·89;P= 0·013).ConclusionsInfant malnutrition was associated with different sociodemographic determinants between urban and rural areas in the Ecuadorian highlands, a finding which contributes to prioritize the determinants to be assessed in nutritional interventions.
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Sehl, Mary Elizabeth, Wenbin Guo, Colin Farrell, Natascia Marino, Jill E. Henry, Anna Maria Storniolo, Jeannette Papp et al. „Abstract P2-11-06: Differential gene expression patterns in healthy breast tissue exhibiting epigenetic age acceleration“. Cancer Research 82, Nr. 4_Supplement (15.02.2022): P2–11–06—P2–11–06. http://dx.doi.org/10.1158/1538-7445.sabcs21-p2-11-06.
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Abstract Introduction: Breast tissue age, measured with DNA methylation-based estimates, is accelerated in healthy women compared with matched peripheral blood samples. While we have shown that the degree of acceleration in breast epigenetic age is related to hormonal factors including elevated body mass index and earlier age at menarche, no prior work has examined alterations in gene expression that accompany breast epigenetic aging. In this study, we examine gene expression patterns associated with epigenetic age acceleration in healthy breast using six epigenetic clocks. Methods: Using the AllPrep (Qiagen) DNA/RNA Kit, we extracted DNA and RNA from the same breast tissue specimens from 192 healthy women aged 19-90 years who donated breast tissue to the Susan G. Komen Tissue Bank at the Indiana University Simon Comprehensive Cancer Center. Transcriptome analysis was performed using the QuantSeq 3’MRNA-SeqFWD kit to generate RNA sequencing libraries. DNA methylation was quantified using the Illumina EPIC 850K array platform, and methylation age was estimated using beta-values from these experiments. Age acceleration is defined using the residuals of a linear regression of methylation age on chronologic age, and samples with positive residuals were characterized as exhibiting epigenetic age acceleration. Differential gene expression analysis was performed using DESeq2 bioconductor software to estimate variance-mean dependence in count data and using a negative binomial distribution model to test for differential gene expression in samples with accelerated epigenetic age in 6 epigenetic clocks: the Horvath pan-tissue clock, Hannum Age, Phenotypic Age, Grim Age, Skin and Blood clock, and the Epigenetic Pacemaker clock (EPM) , a newly developed clock that accounts for curvilinearity in methylation-based estimates of age over time. Results: Principal components analysis revealed that a large proportion of the variance in gene expression was explained by the first two components (PC1 8.6%, PC2 8.2%). Using a false discovery rate cutoff of 0.05, we found 17 (pan-tissue), 909 (Hannum), 3573 (Phenotypic), 1459 (Grim), 3081 (Skin and Blood), and 227 (EPM) genes differentially expressed with the presence of epigenetic age acceleration for each clock. Examining overlap of these genes revealed distinct groups of genes differentially expressed with acceleration in each clock, with no genes in common for all clocks, Phenotypic and Skin and Blood clocks sharing 1137 genes; Phenotypic, Grim, and Skin and Blood clocks sharing 726 genes; and few genes shared by 5 out of 6 clocks (41 genes in all clocks except pan-tissue, 5 genes in all clocks except EPM). Gene set enrichment analysis revealed activation of pathways involved in cellular respiration, oxidative phosphorylation, energy derivation, organic acid metabolic processes, and immune response, and suppression of genes involved in embryonic epithelial morphogenesis, epidermal cell differentiation, chromatin organization, and lipoprotein transport. Conclusion: We identified significant alterations in gene expression patterns that accompany breast epigenetic acceleration in healthy female breast, with distinct patterns observed for six epigenetic clocks examined. Pathways involved include epithelial morphogenesis and differentiation, potentially representing a mechanistic link between breast accelerated aging and carcinogenesis. Citation Format: Mary Elizabeth Sehl, Wenbin Guo, Colin Farrell, Natascia Marino, Jill E. Henry, Anna Maria Storniolo, Jeannette Papp, Jingyi Jessica Li, Matteo Pellegrini, Steve Horvath, Patricia A. Ganz. Differential gene expression patterns in healthy breast tissue exhibiting epigenetic age acceleration [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P2-11-06.
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Friend, S. „227 INVITED From genes to drugs“. European Journal of Cancer Supplements 4, Nr. 12 (November 2006): 75. http://dx.doi.org/10.1016/s1359-6349(06)70232-4.
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Jairath, V., A. Armuzzi, R. K. Pai, D. Sun, Y. Li, M. Bassel, N. R. Brett und D. Bojic. „P772 Association of histological remission with long-term clinical outcomes in patients with ulcerative colitis: a multi-national retrospective study with centralized histological assessment“. Journal of Crohn's and Colitis 17, Supplement_1 (30.01.2023): i900—i903. http://dx.doi.org/10.1093/ecco-jcc/jjac190.0902.
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Abstract Background Histological remission (HR) is an achievable therapeutic target in ulcerative colitis (UC), however there is limited data on the association of HR with long-term clinical outcomes. We evaluated the association between HR and a composite outcome of colectomy, UC-related hospitalization, or intravenous (IV) corticosteroid use in patients with UC. Methods This was a multi-national retrospective study of adult patients with UC treated with a biologic or small molecule drug between 09/01/2005 and 06/30/2019 in Canada, Italy, Netherlands and United States. The study included biologic-naïve (bio-naïve) and biologic-experienced (bio-exp) patients. Biopsies taken during routine practice were procured and re-assessed for histological activity by blinded gastrointestinal pathologists in a central laboratory. HR was defined as the absence of neutrophilic inflammation (Nancy Histological Index ≤1 or Robarts Histological Index ≤3 plus Geboes subgrades 2B.0/3.0) at the most recent endoscopic evaluation within 3 to 9 months after treatment initiation. Cumulative risk of time-to-event outcome over 12 months from treatment initiation was evaluated using Kaplan-Meier (KM) methods and Cox proportional hazard analysis. Statistical significance was set as p-value <0.05. Results We included 227 patients with UC (bio-naïve and bio-exp) (Table 1); of whom, 132 (58%) were bio-naïve (Table 2). Of the bio-naïve patients, 62 (47%) achieved HR and 70 (53%) had histologic activity; 9 (6.8%) underwent colectomy, 16 (12.1%) had UC-related hospitalizations, and 8 (6.1%) received IV corticosteroid. Unadjusted time-to-event for the composite outcome was significantly greater in bio-naïve patients who achieved HR compared to those who did not (p=0.0023; Figure 1A). In multivariable analysis, the association of HR on the composite outcome in bio-naïve patients was not statistically significant (adjusted hazard ratio [aHR], 0.26; 95% CI, 0.02-4.42). In the overall patients (bio-naïve and bio-exp), unadjusted (p<0.001; Figure 1B) and multivariable (aHR, 0.32; 95% CI, 0.06-1.75) associations of HR and the composite outcome were similar to the bio-naïve patients. Conclusion We used central reading to evaluate the association of HR and clinical outcomes in patients with UC. While unadjusted KM curves showed that HR was associated with decreased risk of the composite outcome, the association was no longer significant after adjustment for covariates. The target sample size for this study was not achieved and the number of events was small, resulting in reduced statistical power. Future studies are warranted to explore the association further.
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Janni, Wolfgang, Thomas Friedl, Brigitte Rack, Peter A. Fasching, Andreas Hartkopf, Hans Tesch, Ralf Lorenz et al. „Abstract PS06-06: Analysis of ctDNA for the detection of minimal residual disease (MRD) using a tissue-free, multiomic assay in patients with early-stage breast cancer“. Cancer Research 84, Nr. 9_Supplement (02.05.2024): PS06–06—PS06–06. http://dx.doi.org/10.1158/1538-7445.sabcs23-ps06-06.
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Abstract Background: The detection of ctDNA in patients with early-stage breast cancer after completion of adjuvant therapy is associated with a high risk of recurrence. Current clinical guidelines do not recommend routine screening for metastatic disease unless there are clinical signs and symptoms in patients who completed adjuvant therapy. However, ctDNA may serve as an early biomarker of recurrence which may allow effective identification of patients with asymptomatic distant metastases or molecular relapse only, who could benefit from early treatment intervention. Herein, we utilized a tissue-free, multiomic assay for the sensitive and specific detection of MRD in patients with early-stage breast cancer. Methods: Plasma samples were collected from patients with stage I-III breast cancer who were enrolled in the SUCCESS-A phase 3 clinical trial (NCT02181101) between 2006 and 2007. All patients received adjuvant chemotherapy +/- endocrine therapy and/or anti-HER2 therapy. Samples were collected approximately two years after completion of adjuvant chemotherapy, and plasma samples selected for analysis were from patients without evidence of disease recurrence prior to sample collection. Presence of MRD was assessed using Guardant Reveal powered by Infinity, which evaluates the epigenomic signals associated with cancer versus normal DNA for the detection of ctDNA. Samples with the presence of ctDNA are characterized for somatic alterations with common sources of interference such as clonal hematopoiesis excluded. An analytically validated bioinformatics pipeline was used for the detection of breast cancer ctDNA. Samples were analyzed blinded to the clinical data. Median survival times were estimated using the Kaplan-Meier method and hazard ratios were calculated based on univariable cox regression models. Results: A total of 311 plasma samples from 311 patients were evaluable. ctDNA was detected in 34% (13/38) of patients who subsequently developed distant recurrence and in none (0/7) of the patients who had local or contralateral breast cancer recurrence. ctDNA was detected in 60% (9/15) of samples that were collected within one year before recurrence. In the ctDNA detected samples from patients who had disease recurrence, the median time from sample collection to recurrence was 7.9 months (range, 1.4-28.6 months). ctDNA was detected in 6 patients who did not have a documented disease recurrence, resulting in a specificity of 97.7% (260/266). In the overall cohort, ctDNA detection was prognostic for recurrence-free survival (RFS; HR 11.0, 95% CI 2.28-53.6; p< 0.0001), distant recurrence-free survival (D-RFS; HR 13.7, 95% CI 2.52-74.9; p< 0.0001), and overall survival (OS; HR 17.4, 95% CI 1.33-227; p< 0.0001). Conclusion: Detection of ctDNA after adjuvant chemotherapy was highly prognostic and demonstrated high specificity in an early-stage breast cancer cohort. Larger, prospective studies are needed to confirm the prognostic value of ctDNA in the post-treatment setting and assess the clinical utility of MRD detection in this population. Citation Format: Wolfgang Janni, Thomas Friedl, Brigitte Rack, Peter A. Fasching, Andreas Hartkopf, Hans Tesch, Ralf Lorenz, Georg Heinrich, Jens-Uwe Blohmer, Tanja Fehm, Volkmar Müller, Andreas Schneeweiss, Matthias Beckmann, Matthias Ruebner, Nadia Harbeck, Klaus Pantel, Derek Dustin, Mingyang Cai. Analysis of ctDNA for the detection of minimal residual disease (MRD) using a tissue-free, multiomic assay in patients with early-stage breast cancer [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PS06-06.
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Kochar, N., D. Tripathi, N. C. McAvoy, J. Leithead, H. Ireland, D. N. Redhead und P. C. Hayes. „227 Management of ectopic varices: The edinburgh experience“. Journal of Hepatology 44 (April 2006): S92. http://dx.doi.org/10.1016/s0168-8278(06)80228-x.
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Koizumi, Rie. „Rater Reliability in Speaking Assessment in a Japanese Senior High School: Case of Classroom Group Discussion and Debate 日本の高校におけるスピーキング評価の採点者信頼性—教室内グループ型のディスカッションとディベートの場合“. JALT Journal 44, Nr. 2 (01.11.2022): 281–322. http://dx.doi.org/10.37546/jaltjj44.2-5.
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高校の授業内スピーキングテストにおいて、シンプルなルーブリックを用い、詳細な採点者トレーニングを行わない場合に採点者信頼性が十分確保できるかを、グループ型のディスカッションとディベートで検証した。227名の高校生の発話をそれぞれ教員2名で採点し、多相ラッシュ分析・一般化可能性理論等で分析した。その結果、採点者間一致度・一貫性と採点者内一貫性の観点で十分な信頼性が満たされていることが示された。グループ型タスクの場合に、ルーブリックにやり取りの適切さでなく言語面の観点を入れる、生徒が話す時間を長めに設定する、生徒の役割や発言する順番を決める、共通認識がある教員で採点を行う等の信頼性を高める方法とその問題点が示唆された。 Securing rater reliability for classroom speaking tests can be difficult because teacher-raters typically do not have much time to engage in rater training to understand and discuss rubrics and scores. Furthermore, a teacher typically faces difficulties asking colleagues to help double mark each student’s performance. Intensive rater training and double scoring are typical procedures to maintain high reliability (Knoch et al., 2021) but are not well practiced in the classroom. However, in some cases, extensive training or double scoring is not necessary when teachers use a rubric with a few criteria and levels, which is simpler than conventional detailed rubrics (Koizumi & Watanabe, 2021). Thus, we use a group discussion and a debate to explore rater reliability when Japanese senior high school teachers use simple analytic rubrics without detailed rater training. We pose the following research questions (RQs): RQ1: To what degree are raters similar in terms of interrater consensus and consistency? RQ2: To what degree do raters score students’ responses consistently? RQ3: How many raters are required to maintain reliability? We analyzed ratings for two speaking tests administrated in September or November to 227 third-year students at a public senior high school. Each test, taken by a group of four students, included either a five-minute group discussion or a 21-minute group debate; the test administration and marking were conducted during the lesson time. An analytic rubric was developed for each task and consisted of three or four criteria with three levels (e.g., content, expression, and technique). Two of the three raters scored each student’s response during the test. Teachers had no time to discuss the rubrics in detail and engaged in only a 10-minute discussion about the rubrics before the tests. The ratings were analyzed separately for each test using weighted kappa statistics, Spearman’s rank-order correlations, many-facet Rasch measurement (MFRM), and multivariate generalizability theory (mG theory). The results indicated that the overall rater reliability was adequate, but some cases required careful training. For RQ1, the kappa statistics of two raters’ scores for each criterion ranged from poor to substantial agreement (-.06 to .84). Correlations between two raters’ scores ranged from negligible to strong (-.07 to .91) and there were not large differences in rater severity (i.e., differences in fair mean-based average values of 0.07 to 0.16 with full marks of 3). In addition, the overall agreement percentages from MFRM were higher than those predicted by MFRM (e.g., 72.9% > 71.6%). The intrarater consistency examined for RQ2 using Infit and Outfit mean squares from MFRM was also adequate (e.g., 0.86 to 1.35). The number of raters needed to maintain sufficient reliability (Φ = .70) for RQ3 was one at the overall test levels and one to three at the criterion levels. Using simple rubrics, a group discussion task, and a debate task, the results showed that rater reliability can be maintained without extensive rater training. Although the current results may have been affected by study contexts, such as procedures and students’ and raters’ characteristics, they provide pedagogical and methodological implications for developing speaking assessment tasks and procedures and reporting rater reliability statistics from multiple perspectives.
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Agapov, V., I. Yàkimenko, A. Grishin und I. Alexashina. „P.227 The complex examination of patients with lymphangiomas“. Journal of Cranio-Maxillofacial Surgery 34 (September 2006): 190–91. http://dx.doi.org/10.1016/s1010-5182(06)60735-x.
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Heluey, Camila, Alicia Lee und Andrew Crawford. „ODP075 A Rare Case of Intrathymic Parathyroid Adenoma“. Journal of the Endocrine Society 6, Supplement_1 (01.11.2022): A156—A157. http://dx.doi.org/10.1210/jendso/bvac150.319.
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Abstract BACKGROUND: Parathyroid adenomas are the main cause of primary hyperparathyroidism (PHPT). PHPT most often affects adults between ages 50-60 and is considered rare in children and adolescents, representing less than 5% of cases1. It is more common among females than among males in the proportion 3 to 1. During embryogenesis, both the superior and inferior parathyroid glands detach from their pharyngeal origin and migrate towards their final location, posteriorly to the thyroid gland. Migration can be faulty and ectopic glands can appear along the path of embryologic descent2. We present a case of an adolescent male who presented with symptomatic PHPT in the setting of an intrathymic parathyroid adenoma. CASE PRESENTATION: 17-year-old male with no significant past medical history developed symptoms of anxiety, nausea and fatigue. Laboratory values revealed calcium 14.3 mg/dL (8.6-10.3), PTH 227 pg/mL (15-65), 25-dihydroxyvitamin D (vit-D) 8.31 ng/mL (30-100), and phosphorus 1.5 mg/dL (2.5-5. 0). He denied any personal history of bone fractures or nephrolithiasis. CT parathyroid scan showed an enhancing oblong 1.7×0.6 cm lesion in the left upper mediastinal space suggestive of a parathyroid adenoma. Focal sestamibi uptake confirmed a 1.7×0.6 cm enhancing nodule in the left upper anterior mediastinum within the thymus. He was instructed to take 2,000 IU of vit-D daily. Repeat blood work one month later showed that his serum calcium decreased to 13.4 mg/dL and PTH decreased to 122 pg/mL. Additional labs revealed vit-D 16.81 ng/mL, 1,25-dihydroxyvitamin D (calcitriol) 160 pg/mL (19.9-79.3) and 24-hour urine calcium excretion of 409 mg (0-320). Patient underwent successful excision of an intrathymic hyperplastic parathyroid gland adenoma with a >50% drop in peak PTH levels intraoperatively at 10 minutes post excision, later confirmed by pathology. CONCLUSION: This case highlights an adolescent with symptomatic primary hyperparathyroidism due to an intrathymic parathyroid adenoma. Ectopic adenomas have been reported in approximately 4 to 16% of patients with hyperparathyroidism2. When embryological development of the parathyroid glands is defective, it can predispose to the formation of ectopic glands, which is an important cause of failed parathyroid exploration. Unfortunately, PHPT has greater morbidity in the younger age group since most of these patients develop complications from the hypercalcemia, such as kidney stones, hypercalciuria, bone disease and symptoms of abdominal pain/vomiting. This case emphasizes the importance for clinicians to be aware of ectopic parathyroid adenoma in adolescents who present with symptoms and labs consistent with primary hyperparathyroidism. References 1. Roizen J, Levine MA. Primary hyperparathyroidism in children and adolescents. J Chin Med Assoc. 2012;75(9): 425-434. doi: 10.1016/j. jcma.2012. 06. 0122. Chang, B. A., Sharma, A. & Anderson, D. W. Ectopic parathyroid adenoma in the soft palate: a case report. J of Otolaryngol - Head & Neck Surg 45, 53 (2016). doi.org/10.1186/s40463-016-0165-z Presentation: No date and time listed
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Ferrard-Sasson, Gisele, Sylvain Dubucquoi, Eric Hachulla, Lionel Prin, Pierre-Yves Hatron, Jenny Goudemand, Marie-Claire Boffa, Claudine Caron und Marc Lambert. „Diluted Russell viper-venom time improves identification of antiphospholipid syndrome in a lupus anticoagulant-positive patient population“. Thrombosis and Haemostasis 101, Nr. 03 (2009): 577–81. http://dx.doi.org/10.1160/th08-06-0410.
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SummaryThe objective of this retrospective study was to evaluate the potential ability of diluted Russell viper-venom time (dRVVT) to identify antiphospholipid syndrome (APS) in a lupus anticoagulant (LA)-positive patient population, already selected by other LA clotting tests. Our cohort of positive LA patients was first identified in our outpatients population by the following sensitive LA-detecting tests: Rosner index, diluted prothrombin time (dPT) and Rosove index. Then the 227 consecutive LA-positive patients were tested for dRVVT with the same blood sample. Anticardiolipin (aCL) and anti-β2-glycoprotein-I (β2GPI) autoantibodies assays were also performed. APS using Sapporo clinical criteria revised at Sydney, was found in 116 of these 227 consecutive LA-positive patients. Results of the different tests were analysed statistically. Using univariate analysis, dRVVT, dPT, IgG aCL and IgG anti-β2GPI autoantibodies were significantly associated with APS. The receiver operating-characteristics (ROC) curve defined the best cut-off value for dRVVT ratio at 1.61 with a good specificity (78%) and a lower sensitivity (53%). A multivariate analysis using a binary logistic procedure, retained the dRVVT ratio (≥ 1.61) and IgG anti-β2GPI autoantibodies (> 15 USG) as being associated with APS (p = 0.018; odds ratio [OR] 2.39; 95% confidence interval [CI] 1.2–4.7, and p = 0.0001; OR 3.2; 95% CI 1.5–6.5, respectively). To conclude, these results agree with the need for LA criteria favouring specificity over sensitivity. The use of a threshold around 1.6 for dRVVT ratio should help discriminate APS from non-APS patients.
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Ro, Knut. „Sjur Brækhus: Omsetning og kreditt 1. Universitetsforlaget, 1985. 227 s. Kr. 192“. Lov og Rett 26, Nr. 05 (01.05.1987): 318–20. http://dx.doi.org/10.18261/issn1504-3061-1987-05-06.
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KARAGIANNIS, S., J. BAX, A. ELHENDY, H. FERINGA, D. COKKINOS, R. VANDOMBURG, M. SIMOONS und D. POLDERMANS. „227 Detection of coronary artery disease during recovery phase of stress echocardiography“. European Journal of Echocardiography 7 (Dezember 2006): S21. http://dx.doi.org/10.1016/s1525-2167(06)60077-2.
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Saso, Y., T. Seki, S. Chono und K. Morimoto. „An HFA 227-based metered dose inhaler containing furosemide coated with lecithin“. Journal of Drug Delivery Science and Technology 16, Nr. 2 (2006): 147–50. http://dx.doi.org/10.1016/s1773-2247(06)50022-x.
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Shillington, C. „Thermal ecology of male tarantulas (Aphonopelma anax) during the mating season“. Canadian Journal of Zoology 80, Nr. 2 (01.02.2002): 251–59. http://dx.doi.org/10.1139/z01-227.
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During the mating season, male tarantulas abandon their burrows and actively search for widely distributed females, which remain fossorial. As a result, males are exposed to larger fluctuations in environmental conditions without the protection of a permanent retreat. Body temperatures (Tb) of active male tarantulas (Aphonopelma anax) encountered fortuitously in the field ranged from 24.7 to 35.1°C and preferred Tb's measured in a laboratory thermal gradient ranged from 22.1 to 31.3°C. The thermal options available to males at random points in their environment varied substantially throughout the day but temperatures typically exceeded 40°C. In comparison, temperatures within burrows remained below 40°C. Indices calculated from these temperature data suggested that males thermoregulated effectively during the day, while environmental temperatures were within their preferred Tb range at night and so active regulation of Tb was unnecessary. In addition, I determined the exact times that males ceased locomotory activity in the morning (retreat) and when they started activity in the evening (emergence). Data from 23 radio-tagged males indicated that they retreated into temporary burrows between 06:47 and 10:53 CST. Activity commenced again between 16:36 and 20:53 CST as temperatures approached their preferred or selected Tb range.
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Ahmadiani, A., und P. Hassanzadeh. „227 PTIO AND QUERCETIN PREVENT DEVELOPMENT OF DARK NEURONS INDUCED BY INFLAMMATORY PAIN“. European Journal of Pain 10, S1 (September 2006): S62. http://dx.doi.org/10.1016/s1090-3801(06)60230-9.
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Field, C., W. Parulekar, E. Elliott, S. Hunt, L. Pho, S. Schellenberoer, V. Frouhar und J. Palta. „227 Electronic submission and review of radiotherapy planning data for NCIC CTG protocols“. Radiotherapy and Oncology 78 (März 2006): S80. http://dx.doi.org/10.1016/s0167-8140(06)80704-8.
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Stea, S., E. Sarti, L. Lancellotti und M. Moretti. „O.227 A new project for medical rapid prototyping technologies in maxillofacial surgery“. Journal of Cranio-Maxillofacial Surgery 34 (September 2006): 64. http://dx.doi.org/10.1016/s1010-5182(06)60254-0.
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Hoelzer, Dieter, Wolfgang Hiddemann, Anita Baumann, Hartmut Döhner, Ulrich Dührsen, Rainer Fietkau, Martin-Leo Hansmann et al. „High Survival Rate in Adult Burkitt’s Lymphoma/Leukemia and Diffuse Large B-Cell Lymphoma with Mediastinal Involvement.“ Blood 110, Nr. 11 (16.11.2007): 518. http://dx.doi.org/10.1182/blood.v110.11.518.518.
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Abstract With short intensive chemotherapy mainly based on HDMTX, fractionated alkylators and HDAC outcome of Burkitt’s NHL and mature B-ALL (B-ALL) in adults could be improved substantially to CR rates of 80% and overall survival (OS) of 50–70% (Hoelzer et al, Blood, 1996). Further intensification - namely increase of MTX dose - failed to improve these results. Therefore the German Multicenter Study Group for Adult ALL (GMALL) invented in 2002 a new protocol for mature B-ALL/Burkitt and other high-grade NHL, namely primary mediastinal (med) DLBCL, including 6x Rituximab® 375 mg/m2 before each chemo cycle and two R maintenance cycles. In addition 2 cycles based on HDAC 2 g /m2 were included. HDMTX was 1,5 g/m2 in the protocol for younger pts (<55 yrs). Older pts (>55 yrs) received a dose reduced regimen without HDAC and with MTX at 500 mg/m2. 227 pts with Burkitt (27=Burkitt-like), B-ALL or med DLBCL aged between 16 and 78 enrolled between 09/02 and 12/06 were evaluable for response after the first two cycles. The median age was 36 yrs for Burkitt, 46 for B-ALL and 35 for med DLBCL; 18%, 41% and 12% were older than 55 yrs respectively. The subgroups were characterised as follows: 115 Burkitt (stage III–IV 52%, extranodal inv. 78%, aaIPI >1 47%), 70 B-ALL, 42 med DLBCL (stage III–IV 55%, extranodal inv. 71%, aaIPI >1 61%). The CR rate was 90% in Burkitt, 83% in B-ALL and 69% in med DLBCL; death under therapy occurred in 3%, 11% and 0% respectively. The overall survival at 3 yrs was 91% for Burkitt, 79% for B-ALL and 90% for med DLBCL in pts at the age of 15–55 yrs and 84%, 39% and 67% (N=5) respectively in pts >55 yrs. CNS relapses were observed in 3 out of 22 older CR patients with B-ALL whereas in younger pts the CNS relapse rate was 0. CNS relapses are among the reasons for inferior outcome in elderly B-ALL in contrast to elderly pts with Burkitt or med DLBCL. CNS relapse rate may hopefully be reduced by inclusion of an intermediate dose ARAC cycle in the elderly B-ALL. There was no difference in OS between pts with Burkitt (92%) vs Burkitt-like NHL (86%). Since no prognostic factors could be identified in younger pts, there was no need for SCT in CR1. Major grade III/IV toxicity was hematological (28–37%) and mucositis (36%, 37%, 28% in cycles A1, B1, C1 respectively). Compared to the previous GMLL trial B-NHL90 (without Rituximab) with 270 pts the OS of 272 patients (including LBL, LCAL, DLBCL) at 3 yrs improved significantly from 54% to 80% (p<.0001) overall, 56% to 85% (p<.0001) in younger and 39% to 65% (p=.01) in older pts. In this largest prospective study of adult Burkitt’s lymphoma/leukemia and med DLBCL the combination of Rituximab and 6 short intensive chemo cycles was feasible and lead to an OS of 90% in NHL and 79% in mature B-ALL in the younger patient cohort. Even in older pts with Burkitt’s NHL survival was 84%. The further aim is now to reduce toxicity, namely mucositis.
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Kashirina, N. M., P. N. Rutkevich, E. V. Yanushevskaya, M. M. Peklo, M. A. Slinkin, T. N. Vlasik und A. Y. Shevelev. „Mo-P3:227 Easy-to-use system for testing efficiency of targets for RNA interference“. Atherosclerosis Supplements 7, Nr. 3 (Januar 2006): 96. http://dx.doi.org/10.1016/s1567-5688(06)80361-2.
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Tang, C. K., X. Y. Dai, X. Ou, J. H. Yang, D. L. Cao, X. R. Hao, G. H. Yi, Z. Wang, L. S. Liu und Y. Z. Yang. „Th-P15:227 Alteration of ATP binding cassette transporter A1 on liver in atherosclerotic minipigs“. Atherosclerosis Supplements 7, Nr. 3 (Januar 2006): 543. http://dx.doi.org/10.1016/s1567-5688(06)82186-0.
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Schuler, D., C. Geidel, K. Weber, P. Bittner-Dersch und H. Lindemann. „227 Early detection of exacerbation of allergic bronchopulmonary aspergillosis in Cystic Fibrosis by lung function testing“. Journal of Cystic Fibrosis 5 (2006): S53. http://dx.doi.org/10.1016/s1569-1993(06)80209-2.
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Protsenko, Sergey A., und Evgeny V. Tsaplin. „PERSONAL AND INTELLECTUAL CHARACTERISTICS OF THE REPUTATION OF AN EMPLOYEE IN THE CIVIL SERVICE AS AN ELEMENT OF HUMAN CAPITAL“. SCIENTIFIC REVIEW. SERIES 2. HUMAN SCIENCES, Nr. 1-2 (2022): 71–91. http://dx.doi.org/10.26653/2076-4685-2022-1-2-06.
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The article presents a study that examines the factors of intelligence and personality of employees that affect their reputation. Respondents: 1,047 municipal employees. Evaluation objects: 227 managers. The sociometry method was used to study the reputation of employees. The factors of intelligence were investigated by the method of "Standardized Intellectual Potential Test" (TIPS). Personal factors were investigated by the method of "11 personal factors" (11LF). The data were processed by the t-Student criterion. Differences in the severity of intellectual and personal factors among managers with different reputations were revealed. Recommendations on the introduction of reputation management technologies in the public service are given.
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Gaudy, C., S. Aymond, L. D'Alteroche, Y. Bacq, F. Barin, A. Goudeau und F. Dubois. „P.227 Natural history of hepatitis C in twenty patients detected at the early stage of infection“. Journal of Clinical Virology 36 (Januar 2006): S132. http://dx.doi.org/10.1016/s1386-6532(06)80407-5.
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Kaas, R., J. L. Peterse, S. H. Muller, A. A. M. Hart und E. J. T. Rutgers. „227 ORAL Stage of tumors detected in the surveillance of women at high risk for breast cancer“. European Journal of Surgical Oncology (EJSO) 32 (November 2006): S67—S68. http://dx.doi.org/10.1016/s0748-7983(06)70662-x.
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Crawley, Melissa Ann, Matthew K. Stein, Kruti Patel und Michael G. Martin. „Clinical Trial Availability in Adolescent and Young Adult Patients with Non-Hodgkin Lymphoma“. Blood 128, Nr. 22 (02.12.2016): 5937. http://dx.doi.org/10.1182/blood.v128.22.5937.5937.
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Abstract Introduction Incidence of non-Hodgkin lymphoma (NHL) in adolescent and young adults (AYAs) has increased over the last 25 years. Diffuse large B-cell lymphoma (DLBCL), Burkitt lymphoma, anaplastic large cell lymphoma, lymphoblastic lymphoma, and primary mediastinal B-cell lymphoma are the most common subtypes in patients between the ages of 15 and 19; follicular lymphoma has increased incidence in AYAs who are at least 20 years old.1 Additionally, AYAs with non-Hodgkin lymphoma have increased relapse rates and increased mortality compared to both their childhood and adult counterparts.2 Clinical trials of novel agents often exclude subjects under the age of 18. Because of this, we hypothesized that treatment in adult centers may be associated with increased availability of clinical trials studying novel agents in these at-risk patients. Methods A keyword search of "Non-Hodgkin Lymphoma" in the database maintained by ClinicalTrials.govwas performed on May 1, 2016. Age groups, sample size, information on the studied agents, and lymphoma subtypes were collected, as well as whether study sites were members of the Children's Oncology Group. Seventeen categories of novel agents were identified; data was collected on any novel agent contained within a trial protocol. Results Of the 726 trials in the initial data set, 404 trials were included in our analysis; studies were excluded from the analysis if the study regimen did not contain a novel pharmacologic agent, or if they focused solely on a transplant conditioning regimen. Sixty-one studies (15%) of novel agents were open to enrollment for subjects under the age of 18 (Table 1). Twenty-five (25) of these trials of these utilized cellular therapy (CAR-T cells, donor lymphocytes, and cytotoxic T lymphocytes). Trials of tyrosine kinase inhibitors (7), novel small molecules (7), monoclonal antibodies (5) were the next-most common agents utilized in clinical trials with the remaining agent classes further detailed in Table 2. Of the 343 trials that were limited to patients who were at least 18 years old, 227 (66%) trials allowed the enrollment of subjects with DLBCL, Burkitt lymphoma, anaplastic large cell lymphoma, lymphoblastic lymphoma, follicular lymphoma, and primary mediastinal B cell lymphoma. All agent classes were represented in trials open to patients who were at least 18 years old; however, three agent classes were excluded from clinical trials in the under-18 subset: BiTE immunotherapy, PI3K inhibitors, and pleiomorphic pathway modifiers. Additionally, 178 of 343 trials (51%) included in the analysis that excluded patients under 18 years old had at least one study site which was a member of the Children's Oncology Group. Conclusions Adolescent and young adult patients with non-Hodgkin lymphoma have higher relapse rates and lower survival rates than both their pediatric and older adult counterparts. The vast majority of trials study novel agents in the NHL subtypes that most commonly affect the adolescent and young adult population. Half of the trials that exclude patients under 18 years old take place at Children's Oncology Group member sites. While this suggests that adolescent and young adult patients treated at Children's Oncology Group member sites may have access to trials studying novel agents, the extent to which AYAs are being enrolled in these trials requires further study. [1]Hochberg, J., Waxman, I.M., Kelly, K.M., Morris, E. & Cairo, M.S. (2009) Adolescent NHL and Hodgkin lymphoma: state of the science. Br J Haematol, 144, 24-40. [2] Bleyer A, O'Leary M, Barr R, Ries LAG (eds): Cancer Epidemiology in Older Adolescents and Young Adults 15 to 29 Years of Age, Including SEER Incidence and Survival: 1975-2000. National Cancer Institute, NIH Pub. No. 06-5767. Bethesda, MD 2006. Table 1 Age Groups in Clinical Trials for Non-Hodgkin Lymphoma. Table 1. Age Groups in Clinical Trials for Non-Hodgkin Lymphoma. Table 2 Clinical trial enrollment and COG availability by agent class Table 2. Clinical trial enrollment and COG availability by agent class Disclosures No relevant conflicts of interest to declare.
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Yamanaka, Junko, Valentijn Bon, André Schrauder, Christina Peters, Günter Henze und Arend von Stackelberg. „Risk Factors, Treatment and Outcome of 2nd Relapse of Acute Lymphoblastic Leukemia in Children. Results of the ALL-REZ BFM Registry“. Blood 120, Nr. 21 (16.11.2012): 668. http://dx.doi.org/10.1182/blood.v120.21.668.668.
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Abstract Abstract 668 Introduction: Children with second relapse of acute lymphoblastic leukemia (ALL) are largely considered as non-curable and eligible for early clinical phase I /II trials. Nearly no data are available on the outcome of this patient group with conventional intensive therapy, and there is lack of a reliable comparator for the efficacy of new agents. Aim: Aim of the study was to define suitable prognostic factors for children with 2ndALL relapse and to determine an effective standard therapy which could be recommended at least for curative subgroups. Furthermore we aimed to develop a rationale for a standard chemotherapy backbone for future phase I/II combination trials with new agents. Patients and Methods: We retrospectively analysed treatment and outcome of patients with a first relapse of ALL registered at the ALL-REZ BFM trial centre since July 1995 until October 2010 who suffered a subsequent relapse. Out of these, we selected the patients who were re-registered for the treatment at second relapse. Patients were treated individually at the discretion of the treating centre. However, the ALL-REZ BFM study centre provided treatment recommendations including modified ALL-REZ BFM elements, replacing anthracyclines with liposomal daunorubicin (DNX) at equivalent doses. Allogeneic hematopoietic stem-cell transplantation (HSCT) was recommended if a 3rdCR could be achieved. In case of non-response to induction therapy, individual interventional and intensified chemotherapy courses were recommended. Results: A total of 536 patients who had been registered and treated with a 1st relapse of ALL within ALL-REZ BFM trials suffered a subsequent relapse, among those 385 after chemo/radiotherapy and 151 after HSCT. Of these, 258 patients (48%) were re-registered, 227 with 2nd relapse after chemo/radiotherapy and 31 after allogeneic HSCT. The risk profile of the re-registered group was favourable compared to the total group with 2nd relapse with respect to timepoint of the 2nd relapse. Re-registered patients who relapsed after chemo/radiotherapy demonstrated significantly superior probability of 5-year overall survival (pOS=.27±.03) compared with those who relapsed after HSCT (pOS=.04±.04, p=.024). In univariate analysis, time-point (very early, n=110, pEFS=.06±.02; early, n=56, pEFS=.14±.05; late, n=92, pEFS=.39±.05, p<.001) of and age at 2nd relapse were significantly associated to pEFS. In multivariate Cox Regression analysis, the time point of 2ndrelapse and SCT as time dependent covariate were the only independent significant prognostic covariates. Comparing induction therapies of patients who relapsed after chemotherapy, those who received ALL-REZ BFM protocol like therapy (Protocol II-DNX or F1/F2 courses, n=120, pEFS=.33 ± .04) showed significantly better prognosis than patients who received intensive non-protocol like induction therapy (Clofarabine containing regimens, DNX-FLA, FLAMSA, HAM, others; n=67, pEFS=.02±.02) or non-curative induction therapy (maintenance therapy, HSCT without pre-treatment; n=24, pEFS =.04±.04; p<.001). Best fared 60 patients with protocol-like induction, protocol-like consolidation and HSCT in CR3 with pEFS of .46±.07. Conclusion: Children with a 2nd relapse of ALL post allogeneic HSCT or with very early 2nd relapse post chemo/radiotherapy have a dismal prognosis with intensive conventional antileukemic treatment and may be considered as candidates for single drug phase I/II trials. Patients with early or late 2nd relapse of ALL post chemo/radiotherapy have a curative perspective with conventional induction/consolidation therapy, if HSCT in CR3 is performed. For this patient group phase I/II trials should be integrated into a curative treatment strategy. Conventional 4-drug induction therapy with dexamethasone, vincristine, anthracycline, and asparaginase such as Protocol II-DNX, or with dexamethasone, vincristine, HD-MTX and HD-ARA-C (F1/F2) are effective induction elements for children with 2nd ALL relapse that can be considered as a backbone for phase I/II combination trials or as comparators for randomized phase II/III trials with new agents. Disclosures: No relevant conflicts of interest to declare.
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Aggarwal, A. K., J. Fitzpatrick und N. Aggarwal. „AB1192 RESPONSE TO VISCOSUPPLEMENTATION WITH DIFFERENT TYPES OF INTRA-ARTICULAR HYALURONIC ACIDS IN OSTEOARTHRITIS OF THE KNEE – A RETROGRADE INDIAN COHORT STUDY OF MORE THAN 15 YEARS LONGITUDINAL DATA“. Annals of the Rheumatic Diseases 82, Suppl 1 (30.05.2023): 1825.2–1826. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2660.
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BackgroundKnee osteoarthritis (OA) is a progressive degenerative condition resulting in functional loss, pain and discomfort. [1] The current aim of treatment is alleviation of symptoms, improvement of function and joint preservation.Viscosupplementation (VS) with Intra-articular hyaluronic acid (IAHA) injection has been shown to have protective physiochemical functions and may confer disease-modifying, long term effects in OA. [2][3] However, conflicting guidelines, pooling of results for different molecular weight products, and a paucity of long-term clinical studies has resulted in lack of confidence in the results of IAHA.ObjectivesTo determine the primary and sustained response to VS with different types if IAHA in Bilateral Knee OA.To identify whether the response is different for subgroups which are:Type of IAHA,Gender - Males (M) or Females (F), andGrade of OA treated.MethodsWe did a retrospective analysis of a 15-year cohort from a single Indian centre.The inclusion criteria were adults with bilateral knee OA with functional reduction and radiological KL Grade of III and IV, treated with Non-Animal Stabilized Hyaluronic Acid (NASHA) origin IAHA injections.Subjects were stratified into two groups based on the molecular weight of the hyaluronic acid used:High Molecular Weight - 6-8 mg/ml – 6ml single injections (HMW-HA), orVery high Molecular weight – 20 mg/ml – 3 ml injections (VHMW-HA).The primary outcome measure was responder rates determined by those with improvement in total WOMAC scores of > 30% from baseline versus non-responders.Responders with sustained response of at least 12 months or more were determined.ResultsA total of 2037 (F 1467 (72%) & M 570 (28%)) patients were treated.The overall responder rate was 1496 (73.4%) (F 1099 (74.9%) & M 397 (69.6%)).The Primary responder rate was similar for VHMW-HA (73.5% in Gr III OA & 77.0% in Gr IV OA) and HMW-HA (71.0% in Gr III OA & 68.6% in Gr IV OA).The Sustained response in VHMW-HA was greater (60.5% in Gr III OA & 68.5% in Gr IV OA) versus HMW-HA (47.3% in Gr III OA & 46.7% in Gr IV OA).Table 1.The results are summarized in Table -1: -INTERVENTION TYPEVHMW-HAVHMW-HAHMW-HAHMW-HATOTALRATEGRADE OF OAGrade III OAGrade IV OAGrade III OAGrade IV OAN%TOTAL PATIENTS TREATEDTotal (%)684 (33.6%)631 (31.0%)480 (23.6%)242 (11.9%)2037Females509418352188146772.0%Males1752131285457028.0%PRIMARY RESPONDERSTotal (%)503 (73.5%)486 (77.0%)341 (71.0%)166 (68.6%)149673.4%Females394330251124109974.9%Males109156904239769.6%SUSTAINED RESPONDERSTotal (%)414 (60.5%)432 (68.5%)227 (47.3%)113 (46.7%)118658.2%Females3112861668484777.1%Males103146612933985.4%NON RESPONDERSTotal (%)181 (26.5%)145 (23.0%)139 (29.0%)76 (31.4%)54126.6%Females115881016436825.1%Males6657381217330.4%Primary responders – Total WOMAC scores improvement of > 30% from baseline, Sustained responders - Sustained WOMAC improvement for >=12 mts., Non-responders - WOMAC change < 30% or Lost to follow up.OA-Osteoarthritis Knees, Grade III and IV OA - radiological KL Grade, VHMW-HA - Very high Molecular weight hyaluronic acid, HMW-HA -High molecular weight hyaluronic acid.ConclusionThe responders to treatment of 73.4% justify treatment outcome.The primary response to treatment was similar in all the subgroups – Type of IAHA, Grade of OA and Gender.However, the sustained response for 12 months or more was far greater in VHMW-HA versus HMW-HA.References[1]Mathers CD, Bernard C, Iburg KM, et al. Global programme on evidence for health policy. Discussion paper no. 54. 2003.http://www.who.int/healthinfo/paper54.pdf. Accessed 06 June 2019[2]Henrotin Y, Raman R, Richette P, et al. Consensus statement on Viscosupplementation with hyaluronic acid for the management of osteoarthritis. Semin Arthritis Rheum. 2015;45(2):140–149. [PubMed] [Google Scholar][3]du Souich P. Absorption, distribution and mechanism of action of SYSADOAS. Pharmacol Ther. 2014;142(3):362–374. [PubMed] [Google Scholar]Acknowledgements:NIL.Disclosure of InterestsAnish Kumar Aggarwal Speakers bureau: Novartis Healthcare, Pfizer Ltd., Johnson & Johnson, Cipla Ltd., Zydus Lifesciences Ltd., Emcure Pharma Ltd., Lupin Ltd, Intas Pharmaceuticals Ltd., Torrent Pharmaceuticals Ltd. and RPG lifesciences Ltd., JANE FITZPATRICK Consultant of: Bioventus Inc., NAKUL AGGARWAL: None declared.
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Kan, Zhengyan, Ji Wen, Jennifer Webster, Vinicius Bonato, Whijae Roh, Xinmeng Jasmine Mu, Paul Rejto und Jadwiga Bienkowska. „Abstract PO1-14-08: Real-world clinical genomics study of HR+/HER2- metastatic breast cancers treated by CDK4/6i plus endocrine therapies revealed a drug resistant tumor segment characterized by ER independence“. Cancer Research 84, Nr. 9_Supplement (02.05.2024): PO1–14–08—PO1–14–08. http://dx.doi.org/10.1158/1538-7445.sabcs23-po1-14-08.
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Abstract Background CDK4/6 inhibitors (CDK4/6i) plus endocrine therapies (ET) are the standard-of-care for hormone receptor–positive/human epidermal receptor 2–negative metastatic breast cancer (HR+/HER2− mBC). However, drug resistance remains a major unmet need. Investigations of drug resistance mechanisms has been hampered by a dearth of tumor molecular profiling data from the post-treatment setting. To address this challenge, we have conducted a real-world clinical genomics study to better understand the molecular mechanism of CDK4/6i resistance as well as to stratify patients based on integrated multi-omics profiles. Methods We retrospectively analyzed a multi-omics dataset of 400 HR+/HER2- mBC patients who had received CDK4/6i plus ET and developed progressive disease (PD) from the de-identified Tempus database. Pre-treatment and post-progression biopsies were taken 1 year prior to starting the CDK4/6i treatment or following PD respectively. Tempus xT next-generation sequencing (DNA-seq of 648 genes) and RNA sequencing assays were performed on 427 tumor FFPE samples, including 200 pre-treatment, 227 post-progression and 26 longitudinal pairs. Results The median age of the patients was 57 (54.9-57.4) and median progression free survival (PFS) is 379 (341-433) days. Two genes were found to harbor a significant increase in genomic alteration frequencies (GAF) after adjusting for FDR at post-progression vs. pre-treatment – ESR1 (41.9% vs. 15%, p=5.4e-10), RB1 (13.2% vs. 3%, p=8.5e-05). ESR1 and RB1 also harbored high frequencies of acquired genomic alterations among 26 paired samples at 34.6% and 11.5% respectively. TP53 mutation at baseline was significantly associated with shorter PFS at baseline (p=4.23e-05, HR=2.081) and TP53 GAF significantly increased after PD (37% vs. 28.5%, p=0.039). BRCA1/2 pathogenic mutations (p=1.63e-04, HR=3.066), APOBEC mutation signature S13 (p=0.0125, HR=1.55) and CCNE1 gene expression (p=0.024, HR=1.46) were significantly associated with shorter PFS. APOBEC signature (p=0.0035) and CCNE1 expression (p=1.33e-06) also significantly increased post-progression. Among the top molecular features associated with longer PFS were markers of estrogen signaling such as PGR gene expression (p=6.76e-04, HR=0.565) and the Hallmark estrogen response signature (p=0.021, HR=0.679). Applying a multi-omics pattern recognition algorithm, we identified a molecularly distinct cluster (IC1) characterized by down-regulation of estrogen signaling. IC1 is significantly associated with shorter PFS (p=3.72e-05, HR=0.22) and increased from 4% pre-treatment to 23% post-progression (p=7.3e-08). Further, IC1 is strongly enriched in markers previously implicated in CDK4/6i resistance including CCNE1 expression, RB1 mutation and MYC/E2F activation. We then developed machine learning models to predict gene-level dependency trained on cancer cell line expression and CRISPR-KO screen data. These models predicted decreased dependency on ESR1 and CDK4 and increased dependency on CDK2 in IC1, strengthening the association between ER independence and CDK4/6i resistance. Conclusions Our real-world clinical genomics study identified a comprehensive list of biomarkers associated with resistance to CDK4/6i plus ET and estimated patient prevalence for these markers in the post-treatment setting. Integrated and machine-learning analyses identified a subset of aggressive tumors with estrogen independence characteristics that are implicated in CDK4/6i resistance and suggested new therapeutic strategies. Citation Format: Zhengyan Kan, Ji Wen, Jennifer Webster, Vinicius Bonato, Whijae Roh, Xinmeng Jasmine Mu, Paul Rejto, Jadwiga Bienkowska. Real-world clinical genomics study of HR+/HER2- metastatic breast cancers treated by CDK4/6i plus endocrine therapies revealed a drug resistant tumor segment characterized by ER independence [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO1-14-08.
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Cecchi, E., R. Marcucci, S. Poli, G. Ciuti, D. Poli, S. Ferrini, E. Antonucci, R. Abbate, G. F. Gensini und L. Mannini. „We-P11:227 Hyperviscosity as a possible risk factor for cerebral ischemic complications in nonvalvular atrial fibrillation patients“. Atherosclerosis Supplements 7, Nr. 3 (Januar 2006): 396. http://dx.doi.org/10.1016/s1567-5688(06)81580-1.
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Rahmawati, Farida. „Meningkatkan Hasil Belajar Siswa Materi Pemanasan Global: Penggunaan Media Pembelajaran Puzzle Maker“. Indonesian Journal of Action Research 2, Nr. 1 (10.05.2023): 43–48. http://dx.doi.org/10.14421/ijar.2023.21-06.
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Tujuan – Tujuan penelitian ini untuk mengetahui efektivitas pembelajaran dengan menggunakan media puzzle maker dalam meningkatkan hasil belajar siswa pada materi pemanasan global siswa kelas X MAN 2 Kulon Progo Tahun Ajaran 2022/2023. Metode – Penelitian eksperimen ini menggunakan One-Group Pretest-Posttest Design dengan 57 siswa yang dipilih melalui random sampling dari kelas X-B dan X-C dari populasi 227 siswa. Kelas X-B menerima perawatan sementara Kelas X-C tidak. Data dikumpulkan dengan menggunakan teknik dokumentasi, tes, dan observasi. Analisis data meliputi analisis butir uji, analisis data awal dengan uji normalitas, dan analisis data akhir dengan uji t sisi kanan dan uji gain. Tujuan penelitian adalah untuk mengetahui efektivitas media pembelajaran Puzzle Maker dalam meningkatkan hasil belajar siswa terhadap pemanasan global di Kelas X MAN 2 Kulon Progo. Hasil – Berdasarkan hasil penelitian dan pembahasan, dapat diperoleh simpulan bahwa penggunaan media pembelajaran Puzzle Maker efektif dalam meningkatkan hasil belajar siswa materi pengukuran dalam kegiatan kerja ilmiah pada siswa kelas X di MAN 2 Kulon Progo. Ada perbedaan hasil belajar antara kelompok eksperimen yang diajarkan menggunakan media pembelajaran Puzzle Maker dengan kelompok control yang diajar tanpa menggunakan media pembelajaran yaitu sebesar 0,67. Oleh karena itu, diharapkan penelitian ini dapat menjadi bahan rujukan untuk guru sebagai media pembelajaran yang dapat digunakan dalam pembelajaran serta untuk peneliti dalam mengembangkan penelitian selanjutnya.
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Huang, S. H., B. O'Sullivan, G. Lockwood, T. Michaelson, J. Waldron, A. Bayley, B. Cummings, L. Dawson, J. Kim und J. Ringash. „227 Prospectively recording outcomes at point-of-care for head and neck cancer: Integrating quality assurance and clinical practice“. Radiotherapy and Oncology 80 (September 2006): S66. http://dx.doi.org/10.1016/s0167-8140(06)80968-0.
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Gelaidan, Hamid Mahmood, und Aliyu Olayemi Abdullateef. „Entrepreneurial intentions of business students in Malaysia“. Journal of Small Business and Enterprise Development 24, Nr. 1 (20.02.2017): 54–67. http://dx.doi.org/10.1108/jsbed-06-2016-0078.
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Purpose The purpose of this paper is to empirically examine the effects of relational support, educational support and self-confidence on entrepreneurial intentions of undergraduate business students in a university. Design/methodology/approach To empirically validate the conceptual model and test the hypothesised relationships, the authors collected data from 227 business students at an AACSB-accredited university in Malaysia through random sampling. Findings The results were based on analyses from structural equation modelling using the SmartPLS software. The findings show that entrepreneurial intention of business students is significantly influenced by educational and relational support; however, the moderating effects of self-confidence in the relationship between educational support, relational support and entrepreneurial intention are not significant. The paper clearly shows that relational and educational supports are two important factors that can influence the entrepreneurial intention of university students. Originality/value This research contributes to literature on entrepreneurial motivations and intentions through its empirical findings of the hypothesised relationships. It theoretically contributes to existing knowledge by integrating relevant themes from entrepreneurial motivations theory and the theory of planned behaviour. Finally, it offers alternative recommendations to university authorities and policymakers about business students’ entrepreneurship intention.
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Sreedharan, Slim. „Bird Ringing Data and Field Notes from The Kelabit Highlands: 1993 to 2010“. Sarawak Museum Journal LXXIII, Nr. 94 (01.12.2014): 123–320. http://dx.doi.org/10.61507/smj22-2014-qzp6-06.
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The initial bird surveys of Sarawak, from 1985 to 1992, covered a few National Parks, and several other lowland sites. From January 1993, until November 2010, a new survey began, to explore a wide expanse of the Kelabit Highlands, including parts of the Pulong Tau National Park. During this eighteen-year period, the sites selected ranged from lower montane areas of the Kelabit plateau close to its border with Kalimantan to the higher montane slopes of Mount Murud massif to the north. The duration of these surveys, largely self-funded, ranged from short-term ones, of ten to fourteen days each, to several extended ones that lasted as long as three continuous months at the same location. A large volume of data, on 227 species, was collected during this time. A small part of it has been analysed to support a series of short papers previously published in The Sarawak Museum Journal. Much of it, however, especially the ringing data, remains unpublished. It is now released into public domain for use by other workers. The data collected in the lowland surveys will be published in a separate paper.