Zeitschriftenartikel zum Thema „2016 b-720“

Abstract Background To assess the associations between family characteristics and influenza vaccination coverage among children. Methods Data were used from the National Health Interview Survey 2011–2016. Results The number of children ranged from 10 720 to 12 991 per year from 2011 to 2016. After adjustment for the high-risk status of influenza complications, sex, age, region, race and office visits of children, children of adults who received influenza vaccination were 3.83–4.79 times (the lowest and the highest odds ratios from 2011 to 2016) more likely to be immunized for influenza. Health insurance (1.36–1.61) was also associated with vaccination in children. However, the education level of family adults (0.59–0.79) and marital status of being widowed/divorced/separated (0.74–0.79) were negatively associated with vaccination uptake in children. The following characteristics were not major concerns with influenza vaccination in children: class of worker, years on the job, physical activity, drinking, smoking, hepatitis B immunization, number of family members aged ≥65 years and the ratio of family income to the poverty threshold. Overall, results from the pooled analysis (2011–2016) were consistent with the above-mentioned findings. Conclusions Promoting parental influenza immunization and access to health insurance may be the most effective tools to promote the coverage of influenza vaccine among children.

Abstract Background As indications for testing for influenza broaden, influenza is increasingly being diagnosed in association with hospitalization in adults. We report data on the burden of illness associated with laboratory confirmed influenza requiring hospitalization (LCI-H) in Toronto, Canada from 2010–2011 to 2015–2016. Methods TIBDN has performed population-based surveillance for LCI-H in adults (≥15years) in Toronto and Peel Region, Canada since 2005. All positive tests for influenza are reported, patients are approached for consent and data collected by chart review and patient/physician interview. Death within 30 days of hospitalization was considered associated with influenza. Population data were obtained from Statistics Canada, with data by underlying condition obtained from literature review and provincial health administrative data. Results Over 6 seasons, 5,591 LCI-H episodes were identified: 1,094 (20%) H1N1, 2,847 (51%) H3N2, 415 (7%) A(not typed), 1A(H3N2 and H1N1) and 1,235 (22%) B. The median age of patients was 71.4 years, with 69.3% of patients over 65 years of age; 3,015 (53.4%) were female, 2,618 (46.8%) had been vaccinated against influenza, and 683 (12.2%) were admitted from nursing homes. Incidence by age, influenza subtype and season is shown in Figures 1 and 2. The average annual incidence in healthy adults was 5 per 100,000, compared with 0.8 per 1,000 in adults with COPD or diabetes, 1.7 per 1,000 in adults with cardiac disease, and >2 per 1,000 in those with underlying kidney disease or immunosuppression. Overall, 12.8% of patients had a significant non-respiratory complication (eg. myocarditis, stroke, C. difficile infection). 720 (12.9%) required ICU admission, and 414 (7.4%) required mechanical ventilation. The median hospital length of stay was 9.58 days (IQR 3-11). None of 226 cases aged <30 years died; the case fatality rate increased from 1.8% in those aged 30–39 to 14.5% in those aged 90+ (Figure 3). Conclusion Despite vaccination programs, influenza is a very common cause of hospitalization and death in our adult population. While surveillance for LCI-H underestimates the overall burden of influenza, it may nonetheless help to appropriately prioritize preventive programs. Disclosures J. Powis, Merck: Grant Investigator, Research grant. GSK: Grant Investigator, Research grant. Roche: Grant Investigator, Research grant. Synthetic Biologicals: Investigator, Research grant. A. Mcgeer, Hoffman La Roche: Investigator, Research grant. GSK: Investigator, Research grant. sanofi pasteur: Investigator, Research grant.

This article examines impoliteness in political TV debates in Lithuania. Study adopts qualitative and quantitative content analysis method to analyze 720 minutes of political debates broadcasted before the 2016 Lithuanian Parliamentary elections. Current paper presents theoretical approach to impoliteness, which is later used in empirical analysis to address 2 main objectives: a) to study impoliteness in terms of directness/indirectness and b) to reveal how face threatening acts (FTAs) are expressed. The results of the study have revealed that impoliteness during political TV debates is almost equally expressed directly and indirectly. Direct impoliteness during political debates can be expressed using all functional types of the sentences. Indirect impoliteness in debates can be modified internally and externally using various language resources: inclusive we form, official addressing words, irony, parantheses. This suggests that impoliteness in the context of political TV debates is a unique phenomenon specified by various creative ways of using the language in order to publicly belittle political opponents.

1. Batanov O. V. Tendentsii rozvytku munitsypalnykh prav liudyny v umovakh hlobalizatsii. Chasopys Kyivskoho universytetu prava. 2016. № 4. S. 47–52. URL: http://nbuv.gov.ua/UJRN/Chkup_2016_4_12 2. Zahalna deklaratsiia prav liudyny: pryiniata ta proholoshena v rezoliutsii 217 A(III) Heneralnoi Asamblei vid 10.12.1948 r. URL: https://zakon.rada.gov.ua/laws/show/995_015?Lang =ru#Text 3. Kuchynska O. P., Ivanov M. S. Zahalnoteoretychne ta prakseolohichne rozuminnia prav liudyny. Visnyk kryminalnoho sudochynstva, 2017. № 1. S. 142–148. 4. Mahnovskyi I. Y. Zahalnoteoretychni aspekty kontseptu pryrodnykh prav liudyny v konteksti pryrodnoho prava. Prava liudyny v period zbroinykh konfliktiv: Zb. materialiv Mizhnarodnoi naukovo-praktychnoi konferentsii prysviach. 25-richchiu Natsionalnoho universytetu «Odeska yurydychna akademiia» (m. Odesa, 18 lystopada 2022 r.) / Nats. un-t «Odeska yurydychna akademiia»; kaf. mizhnarodnoho ta yevropeiskoho prava NU «OIuA»: u 2 t. Odesa, 2022. S. 37–41. 5. Rabinovych P. M. Prava liudyny i hromadianyna: navch. posib. Kyiv: Atika, 2004. 464 s. 6. Rabinovych P. Osnovopolozhni prava liudyny: termino-poniattievyi instrumentarii doslidzhennia ta vykladannia). Pravo Ukrainy. 2015. № 1. S. 9–23. 7. Sotsialno-pravovyi zakhyst ditei v Ukraini: monohrafiia / za red. B. I. Andrusyshyna. Kyiv: Vyd-vo NPU imeni M. P. Drahomanova, 2017. 264 s. 8. Khrystokin H. V. Ideia prav liudyny: poshuk novykh pidkhodiv obgruntuvannia v dobu hlobalnykh transformatsii. Filosofski ta metodolohichni problemy prava. 2021. № 1. S. 92–98. 9. Chetverte pokolinnia prav liudyny: osoblyvosti pravovoho rehuliuvannia, problemy ta perspektyvy rozvytku v sferi okhorony zdorovia: monohrafiia / za zah. red.: d.iu.n., prof. S. B. Buletsy; d.iu.n., dots. M. V. Mendzhul. Uzhhorod: Vyd-vo UzhNU «Hoverla», 2020. 444 s. 10. Yurydychna entsyklopediia: v 6 t. / Yu. S. Shemshuchenko (holova redkol.) ta in. Kyiv: Ukr. entsykl. T. 4: N‒P. 2002. 720 s

Purpose of StudyMore than 100,000 pelvic surgeries to remove ovarian masses (BOM) are performed yearly in the USA only 8% of those remove ovarian cancer. Circulating microRNA are biomarkers for disease detection. Purpose of study:1. To analyze patterns of microRNAs in women with BOM vs. OvCa2. Discover pathway involved malignant transformation.Methods UsedPlasma from 32 women OvCa, 24 controls 32 (BOM) was analyzed using ABI Taqman OpenArray MicroRNA pools A and B to measure the expression of 754 known miRNAs .Real-time PCR was performed on the Taqman Open Array MicroRNA arrays using the Applied Biosystem Open Array Real-Time PCR system. Data were processed using the OpenArray Real-Time qPCR Analysis software and exported for analysis using the Applied Biosystems DataAssist Software Data analysis was done with the R programming language. A cutoff for Ct values at 30 was used. MiRNAs with Ct values higher than 30 were considered not detected. Data was normalized using a mean-centering restricted (MCR), a modification of the traditional delta Ct method and uses miRNAs which are expressed in all samples for data normalization. Statistical analysis was performed via custom scripts based on the R/Bioconductor package LIMMA (Linear Models for Microarray).Summary of ResultsBOM had higher expression (2–14 fold higher) of miRs −195, −126, −139-5p, −27b, −127, −152, −28, −106b, −17, −363, −181a, −192 relative to OvCa (p<0.0006). OvCa over-expressed of miRs −1274a, −720 and −625-3p (p<0.0007). Reactome pathway analysis detected involvement of miRs into pathways of activation of BAD, PI3/AKT signaling in CD28 and activation of BH3 in BOM these pathways were not detected in OvCa (p<0.000596).ConclusionsBOM patients have immune recognition and pro-apoptotic protective circulating microRNAs. It is unknown whether miRs originate in ovary or another tissue. Recent work shows that BH3 mimetics are very effective in inducing cancer cell death.

Green manuring can increase biological activity of the soil, enrich it with organic matter, nutrients and improve its agrophysical and agrochemical properties. The aim of the research was to establish the influence of green manure crops species composition on the productivity of agrophytocenoses and the input of soil organic matter under various hydrothermal conditions. The studies were conducted in 2016–2019 on the experimental fields of the Research Institute of Agriculture of Crimea. Soil – chernozems southern low-humus. Average daily air temperature was: in 2016 – 11.8 °С; in 2017 – 12.7 °С; in 2018 – 12.5 °С; in 2019 – 12.6 °С (average long-term values – 10.8 °С). The amount of precipitation over the years was at the level of 162, 67, 129, 108 % of the norm. The experiments were laid according to B. A. Dospekhov “Methods of field research”. Position of the variants is systematic, triple replication. Fields square – 720 m2. The research subject is green manure crops agrocenoses. The object of the research is the process of forming the productivity of green manure crops. On average, over the years of research, the highest yield of green mass was formed by sweet clover and sainfoin (29.1 and 27.1 t/ha, respectively), winter triticale (24.5 t/ha) and winter rye (25.8 t/ha). T. pratense and P. tanacetifolia were low-yielding. The largest amount of accumulated soil organic matter was detected when rye, triticale, sainfoin and sweet clover were used as green manure; it was 5.88, 5.72, 5.56 and 5.52 t/ha, respectively. We established an average correlation (at 5 % significance level) between the amount of precipitation for the period “sowing – ripeness” in 2016–2017 and the yield of green mass of green manure crops (r = 0.52), as well as dry matter yield (r = 0.59). A negative correlation of average strength was also established between the average daily temperature of the period “sowing – ripeness” in 2017–2018 and yield of green mass (r = –0.66), as well as organic matter yield (r = –0.64).

Rapid urbanization rates impact significantly on the nature of Land Cover patterns of the environment, which has been evident in the depletion of vegetal reserves and in general modifying the human climatic systems (Henderson, et al., 2017; Kumar, Masago, Mishra, & Fukushi, 2018; Luo and Lau, 2017). This study explores remote sensing classification technique and other auxiliary data to determine LULCC for a period of 50 years (1967-2016). The LULCC types identified were quantitatively evaluated using the change detection approach from results of maximum likelihood classification algorithm in GIS. Accuracy assessment results were evaluated and found to be between 56 to 98 percent of the LULC classification. The change detection analysis revealed change in the LULC types in Minna from 1976 to 2016. Built-up area increases from 74.82ha in 1976 to 116.58ha in 2016. Farmlands increased from 2.23 ha to 46.45ha and bared surface increases from 120.00ha to 161.31ha between 1976 to 2016 resulting to decline in vegetation, water body, and wetlands. The Decade of rapid urbanization was found to coincide with the period of increased Public Private Partnership Agreement (PPPA). Increase in farmlands was due to the adoption of urban agriculture which has influence on food security and the environmental sustainability. The observed increase in built up areas, farmlands and bare surfaces has substantially led to reduction in vegetation and water bodies. The oscillatory nature of water bodies LULCC which was not particularly consistent with the rates of urbanization also suggests that beyond the urbanization process, other factors may influence the LULCC of water bodies in urban settlements. Keywords: Minna, Niger State, Remote Sensing, Land Surface Characteristics References Akinrinmade, A., Ibrahim, K., & Abdurrahman, A. (2012). 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Financial performance is an achievement achieved by a company that can be seen through financial statements. Financial statements can be used as a control, a source of financial information and a representation of the company's performance. The results of financial statement analysis with various sizes of financial ratios can be used as material for evaluating company performance This study aims to determine the effect of family ownership, institutional ownership, and funding decisions on financial performance as measured by the Piotroski F-Score method. The number of samples in this study were 360 companies from the manufacturing sector with sub-sector basic and chemical industry, various industrial sectors and consumer goods listed on the Indonesia Stock Exchange during the period 2017 - 2019. The results of this study indicate that the data can be pooled for 3 years, all classical assumption tests are met and the results of the regression test show that family ownership > 0.05, institutional ownership and funding decisions < 0.05. So it can be concluded that there is not enough evidence of family ownership to have a positive effect on financial performance. Meanwhile, there is sufficient evidence that institutional ownership and funding decisions have a negative effect on financial performance. Keywords: family ownership, institutional ownership, funding decisions, financial performance and Piotroski F-Score. References: Agatha, B. R., Nurlaela, S., & Samrotun, Y. C. (2020). Kepemilikan Manajerial, Institusional, Dewan Komisaris Independen, Komite Audit dan Kinerja Keuangan Perusahaan Food and Beverage. E-Jurnal Akuntansi, Vol. 30 No. 7, 1811. Aprianingsih, A., & Yushita, A. N. (2016). 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Background:Complement is strongly implicated in the pathogenesis of autoimmune diseases like systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Its component C1q plays a dualistic role, triggering the inflammatory cascade on one hand and directing the clearance of immune complexes on the other. Homozygous genetic deficiency of C1q is strongly associated with SLE and SLE-like phenotype as almost 90% of C1q deficient individuals develop SLE or similar disease. Nevertheless, there are few and inconsistent studies exploring the single nucleotide polymorphisms (SNPs) of the C1q gene cluster in relation to the pathogenesis of SLE and RA.Objectives:The aim of the study was to evaluate the possible association of five SNPs – rs292001, rs172378, rs294179, rs665691 and rs682658 in complement C1q gene cluster with susceptibility to SLE and RA in Bulgarian cohort.Methods:Fifty patients with SLE, sixty-one patients with RA and sixty-seven healthy controls were genotyped for the five SNPs by TaqMan allelic discrimination assay.Results:Frequency of genotypes and alleles of rs294179, rs665691 and rs682658 SNPs was similar between patients with SLE, RA and healthy controls. For rs172378 SNP, the minor G allele (OR = 2.73; 95% CI, 1.59-4.67, p=0.0003) and GG genotype (OR = 5.12; 95% CI, 1.60-16.49, p=0.006) were associated with susceptibility to RA. In our cohort in accordance with others, AA rs292001 SNP genotype was associated with increased risk for RA (OR = 3.32; 95% CI, 1.19-9.20, p=0.021). For SLE patients, AA rs292001 SNP genotype was low presented and did not associate with disease.Conclusion:GG genotype of rs172378 SNP in C1q gene cluster could be considered as a new risk factor for RA.References:[1]Diane Scott et al (2016). The paradoxical roles of C1q and C3 in autoimmunity. Immunobiology, 719-25. doi:10.1016/j.imbio.2015.05.001.[2]Giles JL et al (2015). Functional analysis of a complement polymorphism (rs17611) associated with rheumatoid arthritis. J Immunol., 3029-34. doi:10.4049/jimmunol.1402956.[3]Holers, V. M. (2018). Complement in the Initiation and Evolution of Rheumatoid Arthritis. Frontiers in immunology, 1057. doi:10.3389/fimmu.2018.01057.[4]Lintner, K. E. (2016). Early Components of the Complement Classical Activation Pathway in Human Systemic Autoimmune Diseases. Frontiers in immunology, 36. doi:10.3389/fimmu.2016.00036.[5]Lu, J. &. (2017). C1 Complex: An Adaptable Proteolytic Module for Complement and Non-Complement Functions. Frontiers in immunology, 592. doi:10.3389/fimmu.2017.00592.[6]Manderson, A. P. (2004). The role of complement in the development of systemic lupus erythematosus. Annual review of immunology, 431-456. doi:10.1146/annurev.immunol.22.012703.104549.[7]Martens, H. A. (2009). Analysis of C1q polymorphisms suggests association with systemic lupus erythematosus, serum C1q and CH50 levels and disease severity. Annals of the rheumatic diseases, 715–720. doi:10.1136/ard.2007.085688.[8]Namjou B, G.-M. C. (2009). Evaluation of C1q genomic region in minority racial groups of lupus. Genes Immun., 517-24. doi:10.1038/gene.2009.33.[9]Radanova M et al(2015). Association of rs172378 C1q gene cluster polymorphism with lupus nephritis in Bulgarian patients. Lupus, 280-9. doi:10.1177/0961203314555173.[10]Rafiq S et al (2010). Assessing association of common variation in the C1Q gene cluster with systemic lupus erythematosus. Clin Exp Immunol., 284-9. doi:10.1111/j.1365-2249.2010.04185.x.[11]Schejbel L et al (2011). Molecular basis of hereditary C1q deficiency-revisited: identification of several novel disease-causing mutations. Genes Immun., 626-634.[12]Trouw LA et al (2013). Genetic variants in the region of the C1q genes are associated with rheumatoid arthritis. Clin Exp Immunol., 76-83. doi:10.1111/cei.12097.[13]Trouw L. A. (2017). The complement system as a potential therapeutic target in rheumatic disease. Nature reviews. Rheumatology, 538–547. doi:10.1038/nrrheum.2017.125.[14]Walport M. J. (2002). Complement and systemic lupus erythematosus. Arthritis research, S279–S293. doi:10.1186/ar586.Disclosure of Interests:None declared

Research suggests that child independence is more popular in countries with greater wealth and a higher percentage of the educated population. Various research implications expect children's independence and compliance to increase over time in developing countries. This study aims to describe the independence of early childhood who comes from low-income families or at low socioeconomic environment. Using quantitative descriptive, data collection techniques are carried out through a questionnaire. The study population was 30 respondents from the ECE institution who were included in the list of low-income families in 2018, using an area sampling technique. Overall, the teacher stated that all indicators of dependence on children from low-income families had reached the high category, which was 75%. The implication of further research is that aspects of independence in physical abilities, self-confidence, responsibility, discipline, sociability, sharing, and independence in terms of emotional control in early childhood can develop better in a low socio-economic environment. Keywords: Early Childhood, Independence skills, low-socioeconomic environment References [BPS] Badan Pusat Statistik. (2019). Berita resmi statistik. Bps.Go.Id. Amini, M. (2018). Parental Involvement in Improving Independence in Early Childhood. Advances in Social Science, Education and Humanities Research (ASSEHR), 169(Icece 2017), 190–192. https://doi.org/10.2991/icece-17.2018.48 Blair, C., & Diamond, A. (2008). Biological processes in prevention and intervention: The promotion of self-regulation as a means of preventing school failure. Development and Psychopathology, 20(3), 899–911. https://doi.org/10.1017/S0954579408000436 Blair, C., & Raver, C. C. (2015). School Readiness and Self-Regulation: A Developmental Psychobiological Approach. Annual Reviews Psychology, 3(66), 711–731. https://doi.org/10.1146/annurev-psych-010814-015221.School Bridgett, D. J., Burt, N. M., Edwards, E. S., & Deater-deckard, K. (2015). Supplemental Material for Intergenerational Transmission of Self-Regulation: A Multidisciplinary Review and Integrative Conceptual Framework. Psychological Bulletin, 141(3), 602–654. https://doi.org/10.1037/a0038662.supp Brophy-Herb, H. E., Stansbury, K., Bocknek, E., & Horodynski, M. A. (2012). Modeling maternal emotion-related socialization behaviors in a low-income sample: Relations with toddlers’ self-regulation. Early Childhood Research Quarterly, 27(3), 352–364. https://doi.org/10.1016/j.ecresq.2011.11.005 Buckner, J. C., Mezzacappa, E., & Beardslee, W. R. (2009). Self-Regulation and Its Relations to Adaptive Functioning in Low Income Youths. American Journal of Orthopsychiatry, 79(1), 19–30. https://doi.org/10.1037/a0014796 Charilaos, Z., Anastasia, C., Artemis, G., & Dimitrios, S. (2018). The Relationship Between Performance of Neuromuscular Junction and Social Skills (Co-Operation, Interaction, Independence). European Journal of Physical Education and Sport Science, 4(12), 1–20. https://doi.org/10.5281/zenodo.1455997 Cirino, P. T., Miciak, J., Gerst, E., Barnes, M. A., Vaughn, S., Child, A., Huston-Warren, E., Coelho, V., Cadima, J., Pinto, A. I., Guimarães, C., Dark-Freudeman, A., West, R. L., Eisenberg, N., Sulik, M. J., Huh, Y., Reigeluth, C. M., Kim, S., Holloway, S. D., … Cheah, C. S. L. (2018). Attachment and self-regulation. Personality and Social Psychology Bulletin,16(2), 450–467. https://doi.org/10.1177/0022219415618497 Eisenberg, N., Valiente, C., & Eggum, N. D. (2010). Self-regulation and school readiness. Early Education and Development, 21(5), 681–698. https://doi.org/10.1080/10409289.2010.497451 Ellis, B. J., Boyce, W. T., Belsky, J., Bakermans-Kranenburg, M. J., & Van Ijzendoorn, M. H. (2011). Differential susceptibility to the environment: An evolutionary- neurodevelopmental theory. Development and Psychopathology, 23(1), 7–28. https://doi.org/10.1017/S0954579410000611 Evans, G. W., & Kim, P. (2013). Childhood Poverty, Chronic Stress, Self-Regulation, and Coping. Child Development Perspectives, 7(1), 43–48. https://doi.org/10.1111/cdep.12013 Fay-Stammbach, T., Hawes, D. J., & Meredith, P. (2014). Parenting Influences on Executive Function in Early Childhood: A Review. Child Development Perspectives, 8(4), 258–264. https://doi.org/10.1111/cdep.12095 Havighurst, S. S., Wilson, K. R., Harley, A. E., Prior, M. R., & Kehoe, C. (2010). Tuning in to Kids: Improving emotion socialization practices in parents of preschool children-findings from a community trial. Journal of Child Psychology and Psychiatry and Allied Disciplines. https://doi.org/10.1111/j.1469-7610.2010.02303.x Jimenez-Gomez, C., Haggerty, K., & Topçuoǧlu, B. (2020). Wearable activity schedules to promote independence in young children. Journal of Applied Behavior Analysis, 9999(9999), 1–20. https://doi.org/10.1002/jaba.756 Julian, M. M., Leung, C. Y. Y., Rosenblum, K. L., LeBourgeois, M. K., Lumeng, J. C., Kaciroti, N., & Miller, A. L. (2019). Parenting and Toddler Self-Regulation in Low-Income Families: What Does Sleep Have to do with it? Infant Ment Health J., 40(4), 479–495. https://doi.org/doi:10.1002/imhj.21783 Kaya, İ., & Deniz, M. E. (2020). The effects of life skills education program on problem behaviors and social skills of 4-year-old preschoolers. Elementary Education Online, 19(2), 612–623. https://doi.org/10.17051/ilkonline.2020.692983 Lengua, L. J., Moran, L., Zalewski, M., Ruberry, E., Kiff, C., & Thompson, S. (2015). Relations of Growth in Effortful Control to Family Income, Cumulative Risk, and Adjustment in Preschool-age Children. Journal of Abnormal Child Psychology,43(4), 705–720. https://doi.org/10.1007/s10802-014-9941-2 Meylia, K. N., Siswati, T., Paramashanti, B. A., & Hati, F. S. (2020). Fine motor, gross motor, and social independence skills among stunted and non-stunted children. Early Child Development and Care, 0(0), 1–8. https://doi.org/10.1080/03004430.2020.1739028 Nahar, B., Hossain, M., Mahfuz, M., Islam, M. M., Hossain, M. I., Murray-Kolb, L. E., Seidman, J. C., & Ahmed, T. (2020). Early childhood development and stunting: Findings from the MAL-ED birth cohort study in Bangladesh. Maternal and Child Nutrition, 16(1). https://doi.org/10.1111/mcn.12864 Park, H., & Lau, A. S. (2016). Socioeconomic Status and Parenting Priorities: Child Independence and Obedience Around the World. Journal of Marriage and Family, 78(1), 43–59. https://doi.org/10.1111/jomf.12247 Rhoades, B. L., Greenberg, M. T., Lanza, S. T., & Blair, C. (2011). Demographic and familial predictors of early executive function development: Contribution of a person-centered perspective. Journal of Experimental Child Psychology, 108(3), 638–662. https://doi.org/10.1016/j.jecp.2010.08.004 Schmitt, S. A., Mcclelland, M. M., Tominey, S. L., & Acock, A. C. (2014). a self-regulation intervention. Early Childhood Research Quarterly, 1–12. https://doi.org/10.1016/j.ecresq.2014.08.001

Objective: This study aimed to detect rifampicin-resistant tuberculosis cases and assess the frequency of missing probes in different study populations in Azad Jammu and Kashmir (AJK), Pakistan. Methodology: The study was conducted at the State TB Reference Laboratory, District Headquarters Teaching Hospital, Mirpur, AJK. A total of 2,790 specimens collected between March 2016 to August 2019 were analyzed. Pulmonary TB (PTB) accounted for 94% of the cases, while 6% were classified as extra-pulmonary cases. All respiratory and non-respiratory samples underwent fluorescence smear microscopy (AFB) and a real-time PCR test (Xpert MTB/RIF assay) to detect Mycobacterium tuberculosis (MTB) and rifampicin resistance. Results: Among the 2,790 suspected MTB patients, 734 (26%) were confirmed to have MTB using the Xpert MTB/RIF assay, while 564 (20%) tested positive by fluorescence microscopy. Of the MTB-positive patients, 720 (98%) were diagnosed with pulmonary TB, and 14 (2%) had extra-pulmonary TB. Rifampicin resistance (RR) was detected in 66 (9%) cases, with 97% of the resistant cases being pulmonary and 3% extra-pulmonary. The most frequently missing probe was E (Codon 529-533), accounting for 34% of the cases, followed by probe D (Codon 523-529) at 26%. The least frequently missing probe was C (Codon 523-529), observed in 3% of the cases. Probe B (Codon 512-518) was missing in 15.4% of cases, while probe A (Codon 518-523) was missing in 9.4% of cases. Conclusion: The utilization of molecular diagnostic techniques, such as the Xpert MTB/RIF assay, enables rapid identification of MTB and detection of rifampicin resistance. This study provides valuable baseline data on the prevalence of 81 bp mutations in the rpoB gene, highlighting the need for further evaluation of mutation patterns in AJK.

Ключові слова: пам’ять, ідентичність, національна ідентичність, комеморація, кмеморативні практики. Анотація Національна ідентичність, з одного боку, є однією з фундаментальних ідентичностей, тобто, вона може служити орієнтиром для людини навіть тоді, коли інші (професійні, родинні, класові) швидко змінюються внаслідок трансформації суспільства. З іншого боку, зміни суспільства, його соціальних інститутів (як агентів впливу) змінюють зміст і форми національної ідентичності членів суспільства. Відтак усталення тієї чи іншої моделі ідентичності здійснюється в певному соціальному контексті, який задає не тільки спектр альтернатив, але й набір різних комеморативних практик. У статті обґрунтовується взаємообумовленість смислоконституювання пам’яттєвого та ідентичнісного дискурсів, із урахуванням того, що пам’яттєвий дискурс, з одного боку, віддзеркалює характерні риси національної ідентичності, а з іншого – формує своєрідну смислову основу останньої, моделює її, впливаючи на зміни з різним ступенем інтенсивності. Доведено, що національна ідентичність формується за допомогою колективної пам’яті та комеморативних практик. Посилання Anderson, 2001 – Anderson B. Voobrazhaemыe soobshchestva. Razmыshlenyia ob ystokakh y rasprostranenyy natsyonalyzma [Imaginary communities. Reflections on the origins and spread of nationalism]. M. : Kanon-press, 2001. 288 s. [in Russian] Assman, 2012 – Assman A. Prostory spohadu. Formy ta transformatsii kulturnoi pam’iati [Spaces of memory . Forms and transformations of cultural memory] / per. z nim. K. Dmytrenko, L. Doronicheva, O. Yudin. K.: Nika-Tsentr, 2012. 440 s. (Seriia «Zmina paradyhmy». Vyp. 15). 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Kommemoratsyia ystorycheskykh sobytyi kak ynstrument symvolycheskoi polytyky: Vozmozhnosty sravnytelnoho analyza [Commemorating Historical Events as a Tool of Symbolic Politics: Possibilities for Comparative Analysis] // Polytyia. 2017. № 4 (87). S. 6-11. [in Russian] Malynova, 2018 – Malynova O.Yu. Kommemoratsyia stoletyia revoliutsyy(i) 1917 hoda v RF: analyz stratehyi kliuchevykh mnemonycheskykh aktorov [Commemoration of the centenary of the revolution (s) of 1917 in the Russian Federation: analysis of the strategies of key mnemonic actors] // Polys. Polytycheskye yssledovanyia. 2018. № 1. S. 9–25. [in Russian] Mehyll, 2007 – Mehyll A. Ystorycheskaia epystemolohyia [Historical epistemology] / Perevod Kukartsevoi M., Kashchaeva V., Tymonyna V. M.: «Kanon+»; ROOY «Reabylytatsyia», 2007. 480 s. [in Russian] Nahorna, 2005 – Nahorna L. Identychnist natsionalna [National identity] // Entsyklopediia istorii Ukrainy: T. 3: E-I / Redkol.: V.A. Smolii (holova) ta in. NAN Ukrainy. 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La vigilancia, prevención y control de la rabia es una prioridad para la salud pública, especialmente, la rabia transmitida por perros (variante 1) y la rabia silvestre. El objetivo de esta investigación fue describir el comportamiento epidemiológico del evento entre 2012-2016 en el departamento de Casanare-Colombia. El estudio fue descriptivo, retrospectivo a partir de la notificación de casos al Sistema Nacional de Vigilancia en Salud PúblicaSivigila. Variables a estudio: a) características sociodemográficas, b) agresión/contacto, c) exposición, d) inmunización y e) tratamiento. Aplicación de estadística descriptiva y cálculo de indicadores de vigilancia. Datos analizados con el paquete estadístico Epi-Info 7.2.2.2TM. El 98.5% (6036/6131) de casos procedentes de Casanare, distribuidos en 2012 (1229; 20.4 %), 2013 (1180;19.5 %), 2014 (1227; 20.3 %); 2015 (1153;19.1 %), 2016 (1247; 20.7 %); del 72.5 % del área urbana; 55.4 % del sexo masculino; edad promedio 24.3(± 20.7) valor mínimo 0.01 y valor máximo 97 años; 40.7 % de 5-19 años; 37.5 % estudiantes, 13.3 % amas de casa, 5.4 % menores de edad, 19.4 % con registro de ocupación, de ellos, 29.8 % (349/1172) agricultores; 1.5 % hospitalizados; todos vivos. El 80.6 % (721/894) de exposición leve tuvieron tratamiento adecuado, 4.3 % (37/894) se aplicó suero antirrábico; 91.1 % (653/717) de exposición grave con tratamiento adecuado; 26.7 % (1611/6036) de los casos estuvieron expuestos al virus de la rabia. Incidencia por 100.000 habitantes de exposición rábica: 2012-2016 (344.8); tasa de hospitalización 11.5/100 000. Se evidencia el incumplimiento del indicador de tratamiento adecuado, es decir, en los casos clasificados como exposición leve, aplicar únicamente cinco dosis de vacuna antirrábica (esquema de vacunación completo); y, en exposición grave, aplicar el esquema de vacunación completo y suero antirrábico. Se recomienda continuar/mantener las actividades de vigilancia del evento y los esfuerzos para evitar la transmisión de la rabia humana

ALTURA DE PLANTAS E DIÂMETRO DE COLMOS DE SORGO FORRAGEIRO IRRIGADO EM FUNÇÃO DE CORTES JARDEL HENRIQUE KIRCHNER1; ADROALDO DIAS ROBAINA2; MARCIA XAVIER PEITER3; ROGÉRIO RICALDE TORRES4; WELLINGTON MEZZOMO5 E RICARDO BENETTI ROSSO6 1 Eng. Agrônomo, Doutor, Professor do Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Sul, Rua Nelsi Ribas Fritsch, nº 1111, bairro Esperança, Ibirubá, RS, Brasil, CEP: 98200-000, jardel.kirchner@ibiruba.ifrs.edu.br. 2 Eng. Agrônomo, Doutor, Professor Titular do Departamento de Engenharia Rural, UFSM, Avenida Roraima, nº 1000, bairro Camobi, Santa Maria, RS, Brasil, CEP: 97195-000, diasrobaina@gmail.com. 3 Eng. Agrônoma, Doutora, Professora Associada do Departamento de Engenharia Rural, UFSM, Avenida Roraima, nº 1000, bairro Camobi, Santa Maria, RS, Brasil, CEP: 97195-000, mpeiter@gmail.com. 4 Eng. Agrônomo, Doutor, Professor do Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Sul, Rua Eng. João Viterbo de Oliveira, nº 3061, Zona Rural, Vacaria, RS, Brasil, CEP: 95219-899, rogerio.torres@vacaria.ifrs.edu.br. 5 Eng. Agrônomo, Mestre, Doutorando no Programa de Pós-Graduação em Engenharia Agrícola, UFSM, Avenida Roraima, nº 1000, bairro Camobi, Santa Maria, RS, Brasil, CEP: 97195-000, wmezzomo@hotmail.com. 6 Eng. Agrônomo, Doutor, Professor no Instituto Federal Catarinense, Rodovia SC 283 - km 17, Concórdia, SC, Brasil, CEP: 89703-720, ricardo.rosso @ifc.edu.br. 1 RESUMO A obtenção de elevadas produtividades de pastagens é essencial para a manutenção dos níveis alimentares de rebanhos bovinos. A altura de plantas e o diâmetro de colmos caracterizam-se como determinantes no sucesso produtivo da pastagem pela quantidade de massa produzida. Um dos fatores que alteram esses índices são as precipitações irregulares, tornando necessária a reposição da demanda através da irrigação. O objetivo do trabalho foi avaliar o diâmetro de colmos e a altura de plantas sob diferentes condições hídricas e cortes no sorgo forrageiro, em dois anos agrícolas no estado do Rio Grande do Sul. Foram conduzidos dois experimentos nos anos agrícolas de 2015/2016 e 2016/2017 em Santa Maria (RS), e foram avaliadas as alturas de plantas e os diâmetros de colmos em seis condições hídricas (não irrigado, 25, 50, 75, 100 e 125 % da ETo), em três períodos de cortes (50, 80 e 110 dias após a semeadura) em delineamento blocos ao acaso. Foram encontradas diferenças estatisticamente significativas para a variação da altura de plantas e também do diâmetro de colmos, tanto conforme a lâmina de irrigação, quanto na sequência de cortes. Palavras chave: pastagem irrigada, capacidade de rebrote, irrigação. KIRCHNER, J. H.; ROBAINA, A. D.; PEITER, M. X.; TORRES, R. R.; MEZZOMO, W.; ROSSO, R. B. HEIGHT OF PLANTS AND DIAMETER OF STEMS OF SORGHUM FORAGE IRRIGATED BY CUTS 2 ABSTRACT Achieving high pasture yields is essential for maintaining feed levels in cattle herds. Plant height and stem diameter are determinants of pasture production success by the amount of mass produced. One of the factors that change these rates is irregular rainfall, making it necessary to replenish demand through irrigation. The objective of this work was to evaluate stem diameter and plant height under different water conditions and forage sorghum cuts in two agricultural years in the state of Rio Grande do Sul. Two experiments were conducted in the agricultural years of 2015/2016 and 2016/2017 in Santa Maria / RS, and plant heights and stem diameters were evaluated in six water conditions (non-irrigated, 25, 50, 75, 100 and 125% of ETo), in three cutting periods (50, 80 and 110 days after sowing) in a randomized block design. Statistically significant differences were found for plant height and stem diameter variation, both according to irrigation depth and cut sequence. Keywords: irrigated pasture, regrowth capacity, irrigation.

We discuss here a possibility of generation of steerable states in asymmetric chains comprising three Kerr-like nonlinear oscillators. We show that steering between modes can be generated in the system and it strongly depends on the asymmetry of internal couplings in our model. We can lead to the appearance of new steering effects, which were not present in symmetric models already studied in the literature. Full Text: PDF ReferencesE. Schrödinger, "Discussion of Probability Relations between Separated Systems", Math. Proc. Camb. Phil. Soc. 31, 555 (1935). CrossRef M.D. Reid, "Demonstration of the Einstein-Podolsky-Rosen paradox using nondegenerate parametric amplification", Phys. Rev. A 40, 913 (1989). CrossRef E.G. Cavalcanti, M.D. Reid, "Uncertainty relations for the realization of macroscopic quantum superpositions and EPR paradoxes", Journal of Modern Optics 54, 2373 (2007). CrossRef S.P. Walborn, A. Salles, R.M. Gomes, F. Toscano, P.H. Souto Ribeiro, "Revealing Hidden Einstein-Podolsky-Rosen Nonlocality", Phys. Rev. Lett. 106, 130402 (2011). CrossRef H.M. Wiseman, S.J. Jones, A.C. Doherty, "Steering, Entanglement, Nonlocality, and the Einstein-Podolsky-Rosen Paradox", Phys. Rev. Lett. 98, 140402 (2007). CrossRef S.J. Jones, H.M. Wiseman, A.C. Doherty, "Entanglement, Einstein-Podolsky-Rosen correlations, Bell nonlocality, and steering", Phys. Rev. A 76, 052116 (2007). CrossRef J.K. Kalaga, W. Leoński, "Quantum steering borders in three-qubit systems", Quantum Inf Process 16, 175 (2017). CrossRef Q. He, Z. Ficek, "Einstein-Podolsky-Rosen paradox and quantum steering in a three-mode optomechanical system", Phys. Rev. A 89, 022332 (2014). CrossRef S. Kiesewetter, Q.Y. He, P.D. Drummond, M.D. Reid, "Scalable quantum simulation of pulsed entanglement and Einstein-Podolsky-Rosen steering in optomechanics", Phys. Rev. A 90, 043805 (2014). CrossRef K. Bartkiewicz, A. Cernoch, K. Lemr, A. Miranowicz, F. Nori, "Experimental temporal quantum steering", Scientific Reports 6, 38076 (2016). CrossRef A. Barasiński, B. Brzostowski, R. Matysiak, P. Sobczak, D. Woźniak, In: R. Wyrzykowski, J. Dongarra, K. Karczewski, J. Wasniewski editor, Parallel Processing and Applied Mathematics (PPAM 2013), Lecture Notes in Computer Science, vol 8385. Springer, Berlin, Heidelberg (2014). CrossRef A. Drzewiński, J. Sznajd, "On the real-space renormalization-group study of some 2D quantum spin systems", Physica A 170, 415 (1991). CrossRef G.J. Milburn, C.A. Holmes, "Quantum coherence and classical chaos in a pulsed parametric oscillator with a Kerr nonlinearity", Phys. Rev. A 44, 4704 (1991). CrossRef W. Leoński, "Quantum and classical dynamics for a pulsed nonlinear oscillator", Physica A 233, 365 (1996). CrossRef A. Kowalewska-Kudłaszyk, J.K. Kalaga, W. Leoński, "Long-time fidelity and chaos for a kicked nonlinear oscillator system", Physics Letters A 373, 1334 (2009). CrossRef J.K. Kalaga, W. Leoński, "Two proposals of quantum chaos indicators related to the mean number of photons: pulsed Kerr-like oscillator case", Proc. SPIE 10142, 101421L (2016). CrossRef A. Barasiński, W. Leoński, T. Sowiński, "Ground-state entanglement of spin-1 bosons undergoing superexchange interactions in optical superlattices", J. Opt. Soc. Am. B 31, 1845 (2014). CrossRef A. Barasiński, W. Leoński, "Symmetry restoring and ancilla-driven entanglement for ultra-cold spin-1 atoms in a three-site ring", Quantum Inf Process 16, 6 (2017). CrossRef D. Woźniak, A. Drzewiński, G. Kamieniarz, "Relaxation Dynamics in the Spin-1 Heisenberg Antiferromagnetic Chain after a Quantum Quench of the Uniaxial Anisotropy", Acta Physica Polonica A 130, 1395 (2016). CrossRef R. Szczęśniak, D. Szczęśniak, E.A. Drzazga, "Superconducting state in the atomic metallic hydrogen just above the pressure of the molecular dissociation", Solid State Communications 152, 2023 (2012). CrossRef A. P. Durajski, R. Szczęśniak, M.W. Jarosik, "Properties of the superconducting state in compressed sulphur", Phase Transitions 85, 727 (2012). CrossRef R. Szczęśniak, A. P. Durajski, "The thermodynamic properties of the high-pressure superconducting state in the hydrogen-rich compounds", Solid State Sciences 25, 45 (2013). CrossRef X. Wang, A. Miranowicz, H.R. Li, F. Nori, "Multiple-output microwave single-photon source using superconducting circuits with longitudinal and transverse couplings", Phys. Rev. A 94, 053858, (2016). CrossRef Y.X. Liu, X.W. Xu, A. Miranowicz, F. Nori, "From blockade to transparency: Controllable photon transmission through a circuit-QED system", Phys. Rev. A 89, 043818 (2014). CrossRef M.K. Olsen, "Spreading of entanglement and steering along small Bose-Hubbard chains", Phys. Rev. A 92, 033627 (2015). CrossRef E.G. Cavalcanti, Q.Y. He, M.D. Reid, H.M. Wiseman, "Unified criteria for multipartite quantum nonlocality", Phys. Rev. A 84, 032115 (2011). CrossRef

Методом синхротронной спектроскопии ближней тонкой структуры края рентгеновского поглощения (X-ray Absorption Near Edge Structure – XANES) проведена диагностика массивов столбиков никеля, случайным образом распределенных в слое SiO2 на подложке кремния. Столбики никеля были получены методом электрохимического осаждения металла в поры матрицы диоксида кремния, сформированные трековым методом. Латентные треки формировались путем облучения слоя SiO2 тяжелыми ионами золота на ускорителе института Хан-Майтнер (Берлин, Германия). Методом растровой электронной микроскопии установлены особенности заполнения пор металлом, показана специфика образования столбиков Ni, их морфология (поверхность и сколы). Для исследований электронно-энергетического строения массивов Ni столбиков методом XANES использовалось высокоинтенсивное синхротронное излучение ультрамягкого рентгеновского диапазона накопительного кольца BESSY II Гельмгольц Центра Берлин. Путем анализа локального окружения атомов никеля и кислорода по данным синхротронного метода XANES изучена специфика фазового состава поверхностных слоев, включая интерфейс столбик-матрица. Возможное образование фазы силицида никеля показано лишь при определенных режимах формирования массивов столбиков, в случае частичного разрушения матрицы диоксида кремния и при контакте металла с подложкой Si. Изучена специфика естественного окисления поверхности гетероструктуры столбик никеля - диоксид кремния. ИСТОЧНИК ФИНАНСИРОВАНИЯ Исследование выполнено при поддержке гранта РФФИ (проект №18-32-01046 мол_а) и при частичной поддержке Миниcтеpcтва обpазования и науки Pоccийcкой Федеpации в pамкаx гоcудаpcтвенного задания ВУЗам в cфеpе научной деятельности на 2017–2020 гг. – пpоект № 16.8158.2017/8.9. 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Numerical literacy is the ability needed to use number ideas and arithmetic skills in everyday situations as well as the ability to analyze quantitative data around children. This study aims to determine the effect of the intervention of singing favorite food songs on children's numerical literacy. Using a pretest-posttest experimental design with a control group, this study involved 20 children as research objects, consisting of 10 experimental class children and 10 control class children. The results of the study showed that singing activities with the theme of favorite food influenced the numerical literacy of kindergarten children. This singing activity attracts children's interest, thus showing a significant difference between the experimental class and the control class. Therefore, for further research, it is suggested that early childhood educators can always take advantage of artistic activities such as singing to attract children's interest in any learning. 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Introduction/Objective. In August 2010, World Health Organization declared the beginning of the postpandemic phase of influenza surveillance. The aim of this study was to evaluate the epidemiological and virological characteristics of influenza and correlation between the influenza occurrence and weather conditions. Methods. We used surveillance reports of influenza and laboratory data from October 2010 to May 2015. Data for the analysis were collected through sentinel surveillance of influenza-like illness (ILI), severe acute respiratory illness (SARI), acute respiratory distress syndrome, and by virological surveillance. The nasal and throat swabs from all influenza cases were performed by the PCR laboratory method. Results. During the observed period, the highest rates of ILI were registered during the 2010/11 and 2012/13 seasons, with influenza A (H1N1)pdm09 and influenza B being predominant, respectively. The highest weekly age-specific rates of ILI were registered in school-age children (ages 5?14). Out of 1,466 samples collected, 720 (49.1%) were laboratory confirmed as influenza, and influenza A virus was more frequently detected than influenza B. Among confirmed cases of influenza, participation of patients with SARI or ILI was nearly equal (46% vs. 44.1%). There was a weak correlation observed between the decrease in temperature and rainfall and the increase in influenza detection (? = -0.04214 vs. ? = -0.01545, respectively, p > 0.05). Conclusion. There is a need for continuous surveillance in order to predict seasonal trends and prepare for a timely response to influenza outbreak.

Статья посвящена предварительной публикации набора артефактов из грунтового могильника у с. Комаровка Ульяновской области. Предметы происходят из разрушенного несанкционированными раскопками погребения, совершенного по обряду кремации с преднамеренным повреждением погребального инвентаря. В состав анализируемого комплекса входят длинный однолезвийный клинок, наконечник копья и боевой нож, а также предметы конского снаряжения, украшения и детали костюма. Вероятная датировка комплекса - середина - вторая половина VI в. н.э. Наличие клинкового оружия и особенности погребального обряда делают публикуемый комплекс уникальным для именьковской культуры. Аналогии составляющим его артефактам обнаруживаются в материалах Северного Кавказа и Подунавья, а также Западной Сибири. Появление их в Среднем Поволжье может быть связано с культурными взаимодействиями периода формирования Аварского и Тюркского каганатов. 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Starting from the experimental data referring to the main parameters of the fracture surfaces of some 300-grade maraging steel reported by the classical work published in Nature 308, 721–722(1984), this work studied (a) the multifractal scaling by the main parameters of the slit islands of fracture surfaces produced by a uniaxial tensile loading and (b) the dependence of the impact energy to fracture and of the fractal dimensional increment on the temperature of the studied steels heat treatment, for the fracture surfaces produced by Charpy impact. The obtained results were analyzed, pointing out the spectral (size) distribution of the found slit islands in the frame of some specific clusters (fractal components of the multifractal scaling) of representative points of the logarithms of the slit islands areas and perimeters, respectively.

Background Neisseria meningitidis serogroup B remains a prominent cause of invasive meningococcal disease (IMD) in Brazil. Because two novel protein-based vaccines against serogroup B are available, the main purpose of this study was to provide data on the diversity and distribution of meningococcal vaccine antigen types circulating in Brazil. Methodology Genetic lineages, vaccine antigen types, and allele types of antimicrobial-associated resistance genes based on whole-genome sequencing of a collection of 145 Neisseria meningitidis serogroup B invasive strains recovered in Brazil from 2016 to 2018 were collected. Results A total of 11 clonal complexes (ccs) were identified among the 145 isolates, four of which were predominant, namely, cc461, cc35, cc32, and cc213, accounting for 72.0% of isolates. The most prevalent fHbp peptides were 24 (subfamily A/variant 2), 47 (subfamily A/variant 3), 1 (subfamily B/variant 1) and 45 (subfamily A/variant 3), which were predominantly associated with cc35, cc461, cc32, and cc213, respectively. The NadA peptide was detected in only 26.2% of the isolates. The most frequent NadA peptide 1 was found almost exclusively in cc32. We found seven NHBA peptides that accounted for 74.5% of isolates, and the newly described peptide 1390 was the most prevalent peptide exclusively associated with cc461. Mutated penA alleles were detected in 56.5% of the isolates, whereas no rpoB and gyrA mutant alleles were found. Conclusion During the study period, changes in the clonal structure of circulating strains were observed, without a predominance of a single hyperinvasive lineage, indicating that an epidemiologic shift has occurred that led to a diversity of vaccine antigen types in recent years in Brazil.

Abstract Background A nationwide survey was conducted in Japan from 2018–2019 to investigate the antimicrobial susceptibility of pathogens isolated from surgical site infections (SSI). Methods The resulting data were compared with that obtained in earlier surveys, conducted in 2010, 2014–2015, and 2018-2019. Results Seven main organisms were collected, and in total 2081 isolates were studied. Although a significant increase of extended-spectrum β-lactamase (ESBL) producing organisms among Enterobacteriaceae was demonstrated in 2014–15 (13.5%) compared with 2010 (5.3%), the incidence remained 6.6% in 2018–19. Only one carbapenemase-producing Enterobacteriaceae isolates were identified in the 2018–2019 study. The geometric mean (GM) MICs for ESBL producing isolates in 2018–2019 were 0.08 µg/mL for meropenem, 2.67 µg/mL for tazobactam/piperacillin, 0.40 µg/mL for tazobactam/ceftolozane, 6.35 µg/mL for cefoxitin, and 1.12 µg/mL for gentamycin. Antibiotic susceptible rate in Pseudomonas aeruginosa was 95.5% in meropenem, 93.9% in piperacillin/tazobactam, 100% in tazobactam/ceftolozane, 97.0% in cefepime, 90.9% in ciprofloxacin, and 86.4% in gentamycin. There was no significant difference in methicillin resistance rate of Staphylococcus aureus isolates among 3 study periods (72.0% in 2010, 53.4% in 2014–2015, and 63% in 2018-19). MRSA isolates with a vancomycin MIC of 2μg/mL accounted for 9.7% in 2010, 1.2% in 2014–2015, and 3.1% in 2018-19. GM MICs for MRSA isolates were 2.09 µg/mL for linezolid, 0.32 µg/mL for tedizolid, and 0.61 µg/mL for daptomycin. GM MICs in linezolid and daptomycin for the isolates in 2018–19 tended to be increased compared with isolates in 2010 (1.74 to 2.09 and 0.35 to 0.61 µg/mL, respectively). More than 90% of isolates belonging to the Bacteroides fragilis group remained susceptible to tazobactam/piperacillin, meropenem, and metronidazole. In contrast, lower levels of susceptibility were observed for moxifloxacin (65.3%), cefmetazole (47.2%) and clindamycin (38.9%). In cefoxitin, non-fragilis Bacteroides isolates had lower rates of antibiotic susceptibility compared with B. fragilis. (51.3% vs. 81.8%). Conclusion Overall, the surveillance data clarified trends in antimicrobial susceptibility for organisms commonly associated with SSI. Disclosures Yoshio Takesue, M.D, Ph.D, Astellas Pharma Inc (Speaker’s Bureau)MSD Japan (Speaker’s Bureau)Sumitomo Dainippon Pharma Co. Ltd. (Grant/Research Support) Hiroshige Mikamo, M.D, Ph.D, Astellas Pharma Inc. (Grant/Research Support, Speaker’s Bureau)MSD Japan (Grant/Research Support, Speaker’s Bureau)Pfizer Japan Inc. (Grant/Research Support)Sumitomo Dainippon Pharma Co., Ltd (Grant/Research Support, Speaker’s Bureau)

Background/Aim. After pandemic 2009/10 influenza season, influenza A (H1N1)pdm09, A(H3N2) and B viruses have continued to circulate in the population. The aim of this study was to describe the epidemiological and virological characteristics of influenza and evaluate values of proposed case definitions of influenza like illness (ILI), severe acute respiratory illness (SARI) and acute respiratory distress syndrome (ARDS) for detecting laboratory-confirmed influenza cases in Vojvodina. Methods. We conducted a descriptive epidemiological study using surveillance reports and laboratory data from October 2010 to May 2015 (five surveillance seasons). Results. Out of 1,466 samples collected, 720 (49.1%) were laboratory confirmed as influenza. Influenza A infection was more frequently detected than influenza B infection. Using the case definition of ILI was a good predictor for influenza confirmation (p < 0.05) during 5 influenza seasons. The predominant age-range of patients with confirmed influenza A (42.2%) and B (43.0%) infections was 30 to 64, but the patients aged from 15 to 29 years were more likely to have influenza A (p = 0.0168). In the period from December to January, influenza A (17.8%) was more frequently registered than influenza B (7.6%). The highest number of deaths (19/38) and hospitalized patients (128/402) was registered during the last influenza season (2014/15). The immunosuppressed patients with confirmed influenza infection were more likely to have influenza B than influenza A (p = 0.0110). Conclusion. Our results indicate that influenza surveillance should be continued and expanded in order to fully assess the burden of the disease in given population.

The paper presents an improved algorithm based on Bhaskara Rao and Ramesh Babu’s algorithm to invert magnetic anomalies of three-dimensional basement structures. The magnetic basement is approximated by an ensemble of juxtaposed vertical prisms whose bottom surface coincides with Curie surface with the known depth. The computer program operating with the proposed algorithm is built in Matlab environment. Test applications show that the proposed method can perform computations with fast and stable convergence rate where the results also coincide well with the actual model structure. The effectiveness of the method is demonstrated by inverting magnetic anomalies of the southeast part of Vietnam continental shelf. The calculated magnetic basement relief of the study area provides useful additional information for studies in the aim of dealing with the geological structure of the area.References Beiki M., 2010. 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Asterosiphon Dangeard (1940: 720) presents a monospecific genus of xanthophytes, which can be easily distinguished from other genera in having filamentous siphons and exclusively asexual reproduction. Asterosiphon species forms macroscopic rosette of a few millimeters in diameter consisting of green procumbent and dichotomously branched siphons which are attached to wet soil by scarcely branched colorless rhizoids. The green filaments normally form the chains of akinetes germinating into the new siphons instantly or produce numerous aplanospores. Both ways of reproduction have been thoroughly investigated by Dangeard (1940, 1942) and subsequently by Rieth (1962a, b), who established identity of Asterosiphon siphons with Gongrosira-like stage of thalli ascribed previously to some representatives of the genus Vaucheria de Candolle (1801: 20) (Stahl 1879). The published records of Asterosiphon species are very scarce and concern to a few countries of Europe (Dangeard 1942, Rieth 1962b, Christensen 1986, Langangen 1994, Kusel-Fetzmann 1999, Cambra-Sánchez 2010, Carter & John 2012), Algeria (Gauthier-Lièvre 1954), India (Gupta 2012), China (Liu et al. 1994), and Argentina (Lacoste de Díaz 1981, cit. ex Cambra-Sánchez 2010).

This study aims to determine the differences of learning outcomes between students that were performed using inquiry and student who were applied using problem based learning in classes of X SMA 2 Plakat Tinggi. This study also purposes to examine the effectiveness comparison between problem based learning and inquiry method. The research engages quantitative research with quasi-experimental type. Subject selection conducts match design. The population of this study were students of class X IPS in SMA 2 Plakat Tinggi which composed of three classes. The sample selection in this study engaged purposive sampling, hereby X IPS 3 was elected as experimental group 1 (Problem based learning) and class X IPS 1 as the experimental group 2 (Inquiry) class. Data collection technique performed in this study was learning outcomes in the form of written test. Data analysis technique was engaging independent sample t-test, which was followed by N increased and effect size extent. The findings are differences of learning outcomes improvement between students who studied utilizing inquiry method and students who were taught using problem based learning method. Problem based learning is more effective than inquiry in promoting Geography learning outcomes. This is indicated through calculation result upon effect size extent, where students who were taught using problem based learning method obtain a value of 4.185, larger compared to those who were treated using inquiry method which obtain a value of 3.462. Keywords: Inquiry, problem based learning, Geography References Agustini, D. M. (2017). PBL untuk Meningkatkan Hasil Belajar IPA Siswa Tunarungu Kelas IV A SLBN 2 Bantul. Widia Ortodidaktika, 6(4), 427-437. Alberta. (2004). Focus on Inquiry: A Teacher’s Guide to Implementing Inquiry Based Learning. Canada: Learning Resources Centre. Barret, T., & Moore, S. (2010). New Approaches to: Problem based learning Reveitalising Your Practice in Higher Education. New York: Routledge. Blessinger, P., & Carfora, J. M. (Eds.). (2014). Inquiry-based learning for the arts, humanities and social sciences: A conceptual and practical resource for educators. Emerald Group Publishing. Bridges, S., McGrath, C., & Whitehill, T. L. (Eds.). (2012). Problem-based learning in clinical education: The next generation (Vol. 8). Springer Science & Business Media. Chu, S. K. W., Reynolds, R. B., Tavares, N. J., Notari, M., & Lee, C. W. Y. (2017). 21st Century Skills Development Through Inquiry-Based Learning. doi:10.1007/978-981-10-2481-8 Cohen J. (1988). Statistical Power Analysis for the Behavioral Sciences. New York, NY: Routledge Academic. Duran, M., & Dokme, L. (2016). The Effect of the Inquiry Based Learning Approach on Student’s Critical Thinking Skills. Eurasia Journal of Mathematics, Science & Technology Education, 12(12), 2887-2908. https://doi.org/10.12973/eurasia.2016.02311a. Friesen, S., & David, S. (2013). Inquiry Based Learning Review. Calgary: University of Calgary. Retrieved from https://www.researchgate.net/publication/312592892_Inquiry-Based_Learning_A_Review_of_the_Research_Literature. Goodman, D. (2018). Problem-Based Learning in the MPA Curiculum. Journal of Public Affrairs Education, 14(2), 253-270. Retrieved from http://www.jstor.org/stable/40215813. Grady, G.O., Elaine H.J.Y., Karen, P.L.G., & Henk, G.S. (2012).One Day One Problem an Approach to Problem Based Learning. Singapore: Springer. Handoyono, N.A. (2016). Pengaruh Inquiry Learning Dan Problem-Based Learning terhadap Hasil Belajar PKKR Ditinjau dari Motivasi Belajar. Jurnal Pendidikan Vokasi, 6(1). http://dx.doi.org/10.21831/jpv.v6i1.8114. Hmelo-Silver, C. E. (2004). Problem-based learning: What and how do students learn?. Educational psychology review, 16(3), 235-266. McKeown, T. R., Abrams, L. M., Slattum, P. W., & Kirk, S. V. (2015). Enhancing Teacher Beliefs through an Inquiry-Based Professional Development Program. 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Can Inquiry-Based Learning Strengthen the Links between Teaching and Disciplinary Research? Studies in Higher Education, 35(6), 723-740. https://doi.org/10.1080/03075070903315502. Sumaatmadja, N. (2001). Metode Pengajaran Geografi. Jakarta: BumiAksara. Suprijono, A. (2015). Cooperative Learning Teori & Aplikasi Paikem. Yogyakarta: Pustaka Pelajar Trianto. (2010). Model Pembelajaran Terpadu: Konsep, Strategi, dan Implementasinya dalamKurikulum Tingkat Satuan Pendidikan (KTSP). Jakarta: Bumi Aksara. Unver, A.O., & Sertac, A. (2011).Ovierviews on Inquiry Based and Problem Based Learning Methods. Western Anatolia Journal of Educational Science, 303-309. Retrieved from http://webb.deu.edu.tr/baed/giris/baed/ozel_sayi/303-310.pdf. Warner, R.M. (2008). Applied Statistic. USA: Sage Publications. Westwood, P.S. (2008).What the Teacher Need to Know About Teaching Methods. Camberwell, V: Acer Press. Whitcombe S.W. (2013) Problem-based Learning Students’ Perceptions of Knowledge and Professional Identity: Occupational Therapists as ‘Knowers’, British Journal of Occupational Therapy,76(1), 37-42 Wijayanti, A., & Wulandari, T. (2016). Efektivitas Model CTL dan Model PBL terhadap Hasil Belajar IPS. Harmoni Sosial: Jurnal Pendidikan IPS, 3(2), 112. doi:10.21831/hsjpi.v3i2.7908 Yew, E.H.J., & Karen, G. (2016). Problem-Based Learning: An Overview of its Process and Impact on Learning. Journal Health Professions Education, 2(2), 75-79. https://doi.org/10.1016/j.hpe.2016.01.004\. Yuniawati. (2016). Peningkatan Kualitas Pembelajaran PPKN Melalui Penerapan Problem Based Learning di SMP. Jurnal Pendidikan IPS. Retrieved from https://journal.uny.ac.id/index.php/hsjpi/article/view/7947/8576. Copyright (c) 2019 Geosfera Indonesia Journal and Department of Geography Education, University of Jember This work is licensed under a Creative Commons Attribution-Share A like 4.0 International License

A relação entre água, energia e alimento é um tema que tem recebido atenção no meio acadêmico. Diante da escassez dos recursos naturais, da degradação que tem ocorrido não somente no Brasil, mas no mundo todo, os recursos naturais têm sérios riscos de esgotarem. E há que se pensar em uma gestão que possibilite a recuperação do meio ambiente de forma eficiente e sustentável. Compreendendo que o debate de nexo envolve um conjunto de inter-relações entre os recursos naturais utilizados como insumo para os serviços básicos da vida humana, neste sentido, a presente pesquisa objetivou analisar se há possibilidade de integrar a floresta ao nexo água-energia-alimentos, com vistas a não comprometer as demandas futuras e como isso pode contribuir para alcançar os Objetivos de Desenvolvimento Sustentável (ODS). Os objetivos específicos são identificar a interligação entre água, energia, alimento e floresta; apontar a necessidade de integrar a floresta ao nexo tradicional visando alcançar um desenvolvimento mais sustentável e controlar, prevenir as consequências dos impactos ambientais. A metodologia da revisão literária ocorreu com o levantamento por termos previamente identificados nas bases de dados Scopus, Web of Science e Periódico Capes, sendo a pesquisa classificada com abordagem qualitativa e método dedutivo. Os resultados apontaram que a floresta possui relação direta com os elementos água-energia-alimentos, sendo possível contribuir com as seguranças hídrica, energética e alimentar. Concluiu-se que vincular as florestas ao nexo existente, proporcionará uma maior preocupação para garantir a sustentabilidade e o equilíbrio ambiental. Referências ALROY, John. Efeitos da perturbação do habitat na biodiversidade da floresta tropical. 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Abstract Background: Type 2 diabetes (T2D) has been associated with increased risk of breast cancer. However, the role of metformin, the first-line anti-diabetic drug, in breast cancer carcinogenesis has not been elucidated completely. We aimed to examine further the association between the use of metformin and other anti-diabetic medication and breast cancer incidence within two large prospective cohort studies. Methods: We followed 184,437 women who participated in the Nurses’ Health Study (NHS;1994-2016) and the NHSII (1995-2017), with the baseline tied to the date metformin was introduced into the United States market. Information on T2D diagnosis, metformin, and other anti-diabetic medication, and other covariates were self-reported at baseline and repeatedly assessed by follow-up questionnaires every two to four years. Breast cancer cases were self-reported and confirmed by medical record review. Multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between metformin/other anti-diabetic medication use and breast cancer incidence were estimated using Cox proportional hazards regression models. Results: During 3,412,366 person-years of follow-up, we ascertained 9,442 incident invasive breast cancer cases, of which 720 were among women with T2D. Compared with women without T2D (n=168,498), similar risks of developing breast cancer were observed among those who ever used metformin (HR =0.95; 95%CI=0.79-1.13) and among those who received medications other than metformin (HR =1.11; 95%CI=0.91-1.37). Among women with T2D (n=15,939), compared with never metformin users, ever use of metformin overall was not associated with breast cancer (HR =0.90; 95%CI=0.72-1.13), but a lower risk of breast cancer was observed among past metformin users (HR =0.72; 95%CI=0.52-0.99). Longer duration of metformin use was not associated with risk of breast cancer (each 2-year interval: HR =0.98; 95%CI=0.93-1.03, p-trend=0.32). However, among women with substantial weight increase since age 18 (&gt;25 kg), greater than 5 years of metformin use was associated with a lower risk of breast cancer (HR =0.62; 95%CI=0.43-0.89). Conclusion: Although we observed inverse associations among past metformin users, similar associations were not found among current users. Overall, metformin use was not strongly associated with the risk of developing breast cancer among the general cohort population or among women with T2D. Citation Format: Tengteng Wang, Jae H. Kang, Boyang Chai, Wendy Y. Chen, Michelle D. Holmes, Jennifer Erdrich, Edward L. Giovannucci, Frank B. Hu, Bernard A. Rosner, Rulla M. Tamimi, Walter C. Willett, A. Heather Eliassen. Metformin and other anti-diabetic medication use and breast cancer incidence in the Nurses’ Health Studies [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5902.

Background: Evaluate the Tuberculosis (TB) surveillance system in the Ga West Municipality to determine if it is achieving its objectives, and to assess its attributes and usefulness.Design: Descriptive analysis of primary and secondary dataData source: Stakeholder interviews and record reviews on the objectives and operation of the surveillance system at all levels of the system.Intervention: We evaluated the system’s operation from 2011-2015 using the Centers for Disease Control and Prevention (CDC) updated guidelines for evaluating public health surveillance systems and the World Health Organisation (WHO) TB surveillance checklist for assessing the performance of national surveillance systems.Results: The TB surveillance system in the municipality was functional and operated at all levels for timely detection of cases, accurate diagnosis, and case management. The system improved management of TB/HIV co-infections. The average time taken to confirm a suspected TB case was one day. The registration of a confirmed case and subsequent treatment happen immediately after confirmation. The municipality detected 109 of 727 TB cases in 2015 (case detection rate=15%). The positive predictive value (PPV) was 6.4%. There was one diagnostic centre in the municipality. Private facilities involvement in TB surveillance activities was low (1/15).Conclusion: The Tuberculosis surveillance system in the Ga West Municipality is well structured but partially meeting its objectives. The system is timely, stable and acceptable by most stakeholders and useful at all levels. It has no major data quality issues. Private health facilities in the municipality should be well incorporated into TB surveillance.Keywords: tuberculosis, evaluation, surveillance system, system attributes, Ga WestFunding: This work was supported by Ghana Field Epidemiology and Laboratory Training Program (GFELTP), University of Ghana through the support of the West Africa Health Organization (Ref.: Prog/A17IEpidemSurveillN°57212014/mcrt) to B-YA

Увеличение поголовья сельскохозяйственных животных в РФ влечет за собой образование большого количества навоза. При нарушении условий утилизации навоз приобретает статус отхода. Внедрение в технологический процесс переработки данных отходов альтернативных механизмов, позволяющих ускорить процесс его переработки, является новаторским и актуальным, но требует дополнительных научных исследований. Технология Bedding Recovery Unit (BRU) позволяет ускорить процесс переработки и снизить количество образующихся отходов. Объектом исследования явилась твердая фракция навоза крупного рогатого скота после фильтрационно-сушильной установки BRU FAN 720, используемая в качестве подстилочного материала для животных дойного стада молочной фермы. Исследования включали изучение физико-химических и микробиологических свойств восстановленной подстилки крупного рогатого скота. Технология рециклинга навоза коров при производстве подстилки включала разделение навоза на твердую и жидкую фракции с последующей аэробной обработкой твердой фракции во вращающихся барабанах (биореакторах) при температуре 65–75°C, что способствует значительному сокращению общего числа микроорганизмов. Однако в восстановленной подстилке в значительных количествах присутствует Capnocytophaga ochracea, сохраняют жизнеспособность Staphylococcus epidermidis, Escherichia coli, а также дрожжевые грибы рода Candida. Химический состав восстановленной подстилки близок к составу бесподстилочного навоза, однако восстановленная подстилка имеет более высокий уровень рН. Содержание тяжелых металлов в восстановленной подстилке, за исключением Fe и Zn, незначительно. Внедрение технологии рециклинга навоза крупного рогатого скота с производством подстилочного материала можно рассматривать в качестве перспективного направления ускоренной утилизации соответствующего вторичного продукта, однако необходимо исключить экологические риски, в том числе для здоровья животных и обслуживающего персонала, которые могут возникнуть при внедрении данной технологии в промышленное животноводство. Список литературы Брюханов А.Ю., Попов В.Д., Васильев Э.В., Шалавина Е.В., Уваров Р.А. Анализ и решения экологических проблем в животноводстве // Сельскохозяйственные машины и технологии. 2021. Т. 15,№ 4. С. 48– doi: 10.22314/2073-7599-2021-15-4-48-55. Брюханов А.Ю., Уваров Р.А., Белова Л.М. Предпосылки к формированию санитарно-гигиенических требований к подстилке для крупного рогатого скота // Техника и оборудование для села. 2020. №2. С. 30–34. doi: 33267/2072-9642-2020-2-30-34. Епанчинцева О.С., Трухачев В.И., Никитин В.Я., Гордиенко Л.Н., Семеруненко С.О. Оценка эффективности средств фармакопрофилактики лактационного мастита у коров // Вестник АПК Ставрополья. Ветеринария. 2016. №1. С. 61–65. Койнова А.Н. Отходы в доходы // Эффективное животноводство. Техника и оборудование для животноводства. 2019. №6. С. 40–43. Комякова Е.М., Антонова О.И. Состав навоза крс и свиней, особенности использования и перспективы переработки // Вестник АГАУ. 2020. №6. С. 63–68. Ленченко Е.М., Сачивкина Н.П. Исследование биоплeнок и фенотипических признаков грибов рода Candida // Ветеринария сегодня. 2020. №2. С. 132–138. doi: 10.29326/2304-196X-2020-2-33-132-138. Методические рекомендации по технологическому проектированию систем удаления и подготовки к использованию навоза и помёта. РД-АПК 1.10.15.02-17. М., 2017. 166 с. Оболенский Н.В., Мартьянычев А.В., Вандышева М.С. Биогаз и удобрения из отходов // Экономика и предпринимательство. 2015. №3-2. С.816– Пилип Л.В., Козвонин В.А., Сырчина Н.В., Колеватых Е.П., Ашихмина Т.Я. Влияние подкисления навозных стоков на их микробиологические характеристики // Теоретическая и прикладная экология. 2020. №3. С. 161–167. doi: 25750/1995-4301-2020-3-161-167. Пилип Л.В., Сырчина Н.В. Экологическая проблема отрасли свиноводства // Аграрная наука-сельскому хозяйству / Материалы XIV Международной научно-практической конференции. Барнаул: Алтайский государственный аграрный университет, 2019. С. 193–196. Позывайло О.П., Котович И.В., Копать Н.В., Зайцев С.Ю. Динамика показателей минерального обмена у коров-первотелок в течение лактационного периода // Веснік МДПУ імя І. П. Шамякіна. 2016. №1. С. 68– Сергиенко А.Г., Псюкало С.П., Луханин В.А., Усова Е.В. Исследование свойств подстилочного материала для животных Северо-Кавказского региона // Научный журнал КубГАУ. №109. 2015. С. 597– Сырчина Н.В., Кантор Г.Я., Пугач В.Н., Ашихмина Т.Я. Вклад углекислого газа и воды в парниковый эффект // Теоретическая и прикладная экология. 2021. №4. С. 218–223. doi: 10.25750/1995-4301-2021-4-218-223. Сырчина Н.В., Пилип Л.В., Ашихмина Т.Я. Контроль запахового загрязнения атмосферного воздуха (обзор) // Теоретическая и прикладная экология. 2022. № 2. С. 26–34. doi: 25750/1995-4301-2022-2-026-034. Тарасов С.И., Кравченко М.Е., Бужина Т.А. Влияние длительного регулярного применения бесподстилочного навоза на плодородие, экологическую безопасность дерново-подзолистой супесчаной почвы // Техника и технологии в животноводстве. 2020. №2. С. 90– Antezack А., Boxberger М., La Scola В., Monnet-Corti Isolation and Characterization of Capnocytophaga bilenii sp. nov., a Novel Capnocytophaga Species Detected in a Gingivitis Subject // Pathogens. 2021. No 10(5). P. 547. doi: 10.3390/pathogens10050547. Bromley B., Oultram J.W.H. Are recycled manure solids an appropriate bedding material for dairy cattle compared to traditional materials? // Cattle practice. 2019. Vol. 27 (1). P. 26– Font-Palma C. 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BackgroundStaphylococcus aureus bacteremia (SAB) has high mortality and rheumatoid arthritis (RA) patients are at increased risk,[1] however, the role of anti-rheumatic treatments and disease activity is unclear.[2,3]ObjectivesTo explore the impact of treatment with glucocorticoids and biologic disease-modifying anti-rheumatic drugs (bDMARDs) and disease activity on the risk of SAB in RA patients.MethodsNested case control study in a nationwide cohort of RA patients (DANBIO) with no history of SAB. Cases had a first-time microbiologically verified SAB between 2010-2018. Controls were incidence density matched (age and sex) at time of SAB (index date). We linked data from DANBIO (e.g. disease activity, anti-rheumatic treatment) to other national registries (comorbidities, prescriptions, socioeconomic status, etc). Treatments were redeemed prescriptions or registrations in DANBIO (oral glucocorticoids, bDMARDs) 0-2 years before the index date. Dose of oral glucocorticoids was retrieved from either DANBIO or estimated from the latest prescription. Risk associated with treatment and disease activity was assessed by multivariate conditional logistic regression. For treatments, excess cases/10,000 exposed/year were calculated by multiplying the fully adjusted OR (95%CI) with the incidence rate in the cohort. Missing data was handled by multiple imputation.ResultsWe identified 180 cases in 30,479 RA patients (IR 106.7/100,000 person-years) and matched 720 controls (53% women, median age 73 years, IQR 65;80). For cases, orthopedic implants were frequent (53%/34% for cases/controls), many had recent surgery (38%/5%), longstanding RA (13 years (6;21)/8 (4;14)), joint erosions (48%/39%), moderate (29%/16%) or high (10%/7%) disease activity, and used glucocorticoids (41%/19%) and bDMARDs (31%/20%). Adjusted ORs were high for current use of oral glucocorticoids, especially for doses >10mg/day (OR=14.5 (4.0; 52.2)). For bDMARDs, adjusted OR was 1.9 (1.1; 3.2). Correspondingly, the treatments increased risk with 144 and 9 excess cases/10,000/year, respectively (Table 1). For disease activity, adjusted ORs were >1 (non-significant) for moderate and high disease activity compared with remission (Figure 1).Figure 1.Disease activity and risk of Staphylococcus aureus bacteremiaTable 1.Use of oral glucocorticoids and biologic disease-modifying anti-rheumatic drugs (bDMARDs) 0-2 years before the index date and risk of Staphylococcus aureus bacteremia (SAB)SAB cases,n=180Controls, n=720OR (95% CI)*Number of excess cases/10,000 exposed/year (confidence limits)Glucocorticoidsn (%)n (%)No67 (37)450 (63)refYes113 (63)270 (38)2.4 (1.5; 3.8)15 (6; 30) Former usera39 (22)133 (19)1.7 (0.9; 3.0)NA Current userb74 (41)137 (19)3.2 (1.9; 5.3)23 (9; 46)Current daily dose >0-5 mg44 (24)108 (15)2.1 (1.1; 3.8)11 (1; 30) >5-10mg18 (10)26 (4)3.5 (1.4; 8.6)26 (4; 81) >10mg12 (7)8 (1)14.5 (4.0; 52.2)144 (32; 46)bDMARDsNo111 (62)558 (78)refYes69 (38)162 (23)1.9 (1.1; 3.2)10 (1; 24) Former usera14 (8)18 (3)2.1 (0.8; 5.8)NA Current userb55 (31)144 (20)1.9 (1.1; 3.2)9 (1; 23)a >3 to 24 months before (rituximab >12 to 24 months), b 0-3 months before (rituximab 0-12 months)*adjusted for sex, age, comorbidities, implants, recent surgery, RA disease duration, time since entry, csDMARDs, socioeconomic-, sero-, erosive-, functional- and smoking status, body mass index, and disease activity (high/low/moderate/remission)ConclusionOral glucocorticoids and bDMARDs increased relative risk of SAB, with number of excess cases being high for oral glucocorticoids (>10 mg/day) and low for bDMARDs. Disease activity had minor impact on the risk. This emphasizes that high dose glucocorticoids should be used with caution.References[1] Dieperink SS, resubmitted after revision Jan 2022[2]Smit J et al. 2016 doi:10.1016/j.mayocp.2016.04.023[3]Sams M et al. 2015 doi:10.1007/s00296-015-3239-8AcknowledgementsWe wish to acknowledge the valuable inputs from patient representative Pia Lüchau Pedersen who participated in the initial brainstorming phase that led to the hypotheses being tested in this studyDisclosure of InterestsNone declared

7524 Background: The survival of chronic lymphocytic leukemia (CLL) patients has progressively improved after the approval of new targeted therapy for first-line treatment and relapsed disease. We performed a corresponding analysis from the U.S. population-based SEER database (1973–2017) to explore the trend of survival and the effect of advanced CLL treatment on overall survival in CLL patients. Methods: Data were extracted from SEER*Stat for all patients 15 years or older with a primary diagnosis of CLL with or without subsequent cancers. A period analysis was performed to estimate the 5- and 10-year relative survival rates for patients diagnosed (dx) during different calendar periods from 1985 to 2017, based on gender and age at time of diagnosis (15–44, 45–54, 55–64, 65–74, 75–84, 85 years or older). A mixture cure model was used to examine the proportion of long-term survivors per gender and age category among CLL patients diagnosed between 1985 and 2015. Cox proportional hazard modeling was used to calculate the hazard ratios (HRs) of death adjusted for gender and age at diagnosis for two cohorts: (a) diagnosed in 2000–2003 and followed to 2012; (b) 2004–2007 and followed to 2015. Results: For males, the 5-year age-adjusted relative survival rate improved progressively from 72.0% (dx 1985-1989) to 88.2% (dx 2010-2014); for females, from 76.8% (dx 1985-1989) to 90.8% (dx 2010-2014). The corresponding 10-year age-adjusted relative survival rates were 47.3% (dx 1985-1989) and 72.5% (dx 2005-2009) for males; and 58.2% (dx 1985-1989) and 78.7% (dx 2005-2009) for females. The table below shows the proportions of long-term survivors for the 1985–2017 cohort as estimated in the mixed cure model. The HRs (95%CI) of death for cohort (b) in comparison to cohort (a) were 0.58 (0.43–0.78), 0.58 (0.48–0.70), 0.57 (0.49–0.67), 0.68 (0.54–0.85); and 0.83 (0.68–1.02) for age categories of 45–54, 55–64, 65–74, 75–84, and 85 years or old. Conclusions: Survival is significantly improved by calendar period among patients diagnosed after 2004 and treated in the era of advanced therapies. Females and younger patients had a higher probability of long term survival. Future studies should consider such covariates as treatment type, disease stage and genetics.[Table: see text]

Seismic status in Bangladesh has been investigated using earthquake data recorded by the global network of USGS during 1980 to 2016. Seismicity parameters such as magnitude completeness Mc, b-value and a-value are being estimated. It has observed that the overall b-value in and around Bangladesh is of 0.84 which is seemed to be seismically active zone. As, reliable b-value assessment can lead to better seismic hazard analysis, reliable magnitude of completeness Mc can lead to b-value assessment of an area, this work has dealt and estimated magnitude of completeness Mc using various techniques for the whole region for a reliable estimation. Estimated Mc is obtained to be around 3.9-4.7, which lead to b-value of 0.93. Spatial variations of Mc and b-value have been investigated for 1ox1o horizontal and vertical rectangular regions for the study area between 18-29°N and 84-95°E. Estimated Mc and b-value along with b-value are then averaged for the common regions in the pair of horizontal and vertical regions. Results are then being presented in the form of maps. The findings resemble as, the Mc is low at the border line of N-W Bangladesh, and a line from Cox’s bazaar to Sylhet through Hill tracts. Remain parts belong to the Mc value of 4.1-4.2, thus the b-value obtained is varying from 0.68 to 1.2, where, the value is higher at region in Chittagong and Barisal division that extends toward north through part of Dhaka to Sylhet and lower at Rajshahi, Rangpur and part of Khulna division, while a-value is varying from 5.0 to 7.2 mostly from west to east.ReferencesAbercrombie R.E., and Brune J.N., 1994. Evidence for a constant b-value above magnitude 0 in the southern San Andreas, San Jacinto, and San Miguel fault zones and at the Long Valley caldera, California. Geophys. Res. Lett., 21(15), 1647-1650.Aki K., 1965. Maximum likelihood estimate of b in the formula log N=a-b M and its confidence limits. Bull. Earthquake Res Inst., Tokyo Univ., 43, 237-239.Aki S., 1987. On nonparametric tests for symmetry. Ann. Inst. Statist. Math., 39, 457-472.Al-Hussaini T.M., 2006. Seismicity and Seismic Hazard Assessment in Bangladesh: Reference to Code Provisions. Meeting on Seismic Hazard in Asia ICTP, Trieste, Dec. 4-8.Amorese D., 2007. Applying a change-point detection method on frequency-magnitude distributions. Bull. Seismol. Soc. Am., 97(5), 1742-1749. Doi:10.1785/0120060181.Banglapedia, 2012. The National Encyclopedia of Bangladesh. http://en.banglapedia.org/index.php?title=Tectonic_Framework, retrieved on 31 Aug 2017.Cao A.M., and Gao S.S., 2002. Temporal variations of seismic b-values beneath northeastern Japan island arc. Geophys. Res. Lett., 29(9), 481-483. Doi:10.1029/2001GL013775.Das R., Wason H.R., and Sharma M.L., 2012. Temporal and spatial variations in the magnitude of completeness for homogenized moment magnitude catalogue for northeast India. J. Earth Syst. Sci., 121(1), 19-28.Felzer K.R., 2008. Simulated aftershock sequences for a M 7.8 earthquake on the southern San Andreas fault. Seismol. Res. Lett., 80, 21-25.GSB, 2018. Seismic Zone Map of Bangladesh. http://gsb.portal.gov.bd/sites/default/files/files/gsb.portal.gov.bd/common_document/a6e75ad2_5acd_4fe3_911d_c9d25a7e349e/BD_Sciesmic-zonemap(NBC).pdf, retrieved on 31 March 2018.Gutenberg B., and Richter C.F., 1944. Frequency of earthquakes in California, Bull. Seismol. Soc. Am., 34, 184-188.Gutenberg B., and Richter C.F., 1956. Earthquake magnitude, intensity, energy and acceleration (second paper). Bull. Seismol Soc. Am., 46(2), 105-145.Hafiez H.E.A., 2015. Estimating the magnitude of completeness for assessing the quality of earthquake catalogue of the ENSN. Egypt. Arab J. Geosci., 8(1), 9315-9323. Doi:10.1007/s12517-015-1929-x.Hunting Geology and Geophysics Ltd., (1981), Interpretation and Operations report on an aeromagnetic survey in Bangladesh, Borehamwood, Hertfordshire, England.Iwata T., 2008. Low detection capability of global earthquakes after the occurrence of large earthquakes: investigation of the Harvard cmt catalogue. Geophys. J. Int., 174(3), 849-856. Doi:10.1111/j.1365-246X.2008.03864.x.Kagan Y.Y., 2002. Seismic moment distribution revisited: I. statistical results. Geophys. J. Int., 148(3), 520-541. Doi: 10.1046/j.1365-246x.2002.01594.x.Khan P.K., Ghosh M., Chakraborty P.P., and Mukherjee D., 2011. Seismic b-Value and the Assessment of Ambient Stress in Northeast India. Pure Appl. Geophys., 168(10), 1693-1706. Doi:10.1007/s00024-010-0194-x.Kolathayar S., Sitharam T.G., and Vipin K.S., 2012. Spatial variation of seismicity parameters across India and adjoining areas. Nat Hazards, 60(3), 1365-1379. Doi:10.1007/s11069-011-9898-1.Lomnitz-Adler J., and Lomnitz C., 1979. A modified form of the Gutenberg-Richter magnitude-frequency relation. Bull. Seism. Soc. Am., 69(4), 1209-1214.Marsan D., 2003. Triggering of seismicity at short timescales following Californian earthquakes. J. Geophys. Res., 108, B5, 2266. Doi:10.1029/2002JB001946.Mignan A., 2011. Retrospective on the Accelerating Seismic Release (ASR) hypothesis: Controversy and new horizons. Tectonophysics, 505(1), 1-16. Doi:10.1016/j.tecto.2011.03.010.Mignan A., and Woessner J., 2012. Estimating the magnitude of completeness for earthquake catalogs, Community Online Resource for Statistical Seismicity Analysis. Swiss Seismological Service, ETH Zurich, 145p. Doi:10.5078/corssa-00180805. Available at http://www.corssa.org.Naylor M., Orfanogiannaki, K., and Harte D., 2010. Exploratory data analysis: magnitude, space, and time. Community Online Resource for Statistical Seismicity Analysis, 42p. Doi:10.5078/corssa-92330203. Available at http://www.corssa.org.Ogata Y., and Katsura K., 1993. Analysis of temporal and spatial heterogeneity of magnitude frequency distribution inferred from earthquake catalogues. Geophys. J. Int., 113(3), 727-738. Doi:10.1111/j.1365-246X.1993.tb04663.x.Ogata Y., and Katsura K., 2006. Immediate and updated forecasting of aftershock hazard. Geophys. Res. Lett., 33, 10, L10305. Doi:10.1029/2006GL025888.Rashid H., 1991. Geography of Bangladesh, University Press Ltd, Bangladesh; 2nd edition, 545p.Reimann K.U., 1993. Geology of Bangladesh. Gerbruder Bornt Ramerg, Berlin, Germany, 160p.Siddique S., 2015. Gutenberg-Richter recurrence law to seismicity analysis of Bangladesh. IABSE-JSCE Joint Conference on Advances in Bridge Engineering-III, August 21-22, Dhaka, Bangladesh.Shi Y., and Bolt B.A., 1982. The standard error of the magnitude-frequency b-value. Bull. Seismol. Soc. Am., 72(5), 1667-1687.USGS, 2012. Earthquake Hazards Program. https://earthquake.usgs.gov/earthquakes/search/, USA, retrieved on 20 April 2017.Utsu T., 1999. Representation and analysis of the earthquake size distribution: a historical review and some new approaches. Pure Appl. Geophys., 155(2), 509-535.Wiemer S., and Wyss M., 2000. Minimum magnitude of complete reporting in earthquake catalogs: examples from Alaska, the western United States, and Japan. Bull. Seismol. Soc. Am., 90, 859-869. Doi:10.1785/0119990114.Woessner J., and Wiemer S., 2005. Assessing the quality of earthquake catalogues: Estimating the magnitude of completeness and its uncertainty. Bull. Seismol. Soc. Am., 95(2), 684-698. Doi:10.1785/012040007.Wyss M., Hasegawa A., Wiemer S., and Umino N., 1999. Quantitative mapping of precursory seismic quiescence before the 1989, M7.1 off-Sanriku earthquake, Japan. Annali Di Geoflsica, 42(5), 851-869.Zuniga F.R., and Wyss M., 1995. Inadvertent changes in magnitude reported in earthquake catalogs: Their evaluation through b-value estimates. Bull. Seismol. Soc. Am., 85, 1858-1866..Zuniga F.R., and Wiemer S., 1999. Seismicity patterns: Are they always related to natural causes? Pure Appl. Geophys., 155(2), 713-726.

Abstract The aim of the study was to assess the distribution of Anaplasma phagocytophilum, Borrelia burgdorferi sensu lato, and Babesia canis in adult females and males of Ixodes ricinus and Dermacentor reticulatus ticks, inhabiting meadows near large forest complexes throughout the Lubelskie Voivodship (eastern region of Poland). Ticks were collected using the flagging method. Among 720 ticks collected, 506 were identified as D. reticulatus, and 214 as I. ricinus. DNA of B. canis and B. burgdorferi s.l. was detected in 21.3% and 0.6% of D. reticulatus ticks, respectively. In I. ricinus ticks, DNA specific to B. burgdorferi s.l. and A. phagocytophilum was detected in 5.6% and 10.3%, respectively. Co-infections of B. burgdorferi s.l. and A. phagocytophilum were found in two I. ricinus ticks. These results indicate that the Lublin region is an area at risk of tick-borne diseases of humans and animals, which must be considered in clinical practice.

BackgroundVisual involvement is the most feared complication of Giant Cell Arteritis (GCA) (1-5). Permanent visual loss (PVL) may be preceded by transient visual loss. Once blindness is established, the prognosis is poor. Most of the series of predictive factors of visual involvement in GCA are old and with a small number of patients.ObjectivesTo assess the predictive factors of visual involvement and PVL in GCA.MethodsMulticenter observational study of 471 patients with GCA. The diagnosis of GCA was performed between 2016 and 2021 according to: a) ACR criteria, and/or b) temporal artery biopsy, and/or c) imaging techniques.From the 471 patients, we selected patients who developed a) visual involvement at any time during GCA and b) PVL. PVL was defined as partial or complete visual loss of >24 hours. Predictive factors were identified by multivariate analysis.ResultsVisual involvement was observed in 122 cases and PVL in 60 (Table 1). The ischemic and systemic manifestations set of variables associated with visual involvement were headache, and jaw claudication, whereas large-vessel involvement was a protective variable (Figure 1). The area under the curve (AUC) for the model was 0.72 (95%CI 0.67-0.77; p<0.0001).Figure 1.Forest plot of multivariate analysis.Table 1.Main features of the patientsOverall (n= 471)GCA without visual involvement (n=349)GCA with visual involvement (n= 122)GCA with PVL (n=60)P visual vs non visual involvementP PVL vs non visual involvementAge at diagnosis of GCA (mean±SD)72±971±975±875±90.0010.001Female/Male (% of female)342/129 (73)265/84 (76)77/45 (63)41/19 (68)0.0060.21Positive TAB, n (%)201 (43)146 (42)55 (45)33 (55)0.530.34Cardiovascular risk factorsHigh blood pressure, n (%)272 (58)189 (54)83 (68)40 (67)0.0130.058Dyslipidemia, n (%)241 (51)175 (50)66 (54)32 (53)0.610.63Diabetes, n (%)81 (17)50 (14)31 (25)16 (27)0.0070.016Previous or current smoking history, n (%)47 (10)31 (9)16 (13)8 (13)0.210.27CHADS2 score, median [IQR]1 [1-2]1 [0-2]2 [1-2]2 [1-2]0.0010.004Ischemic manifestationsHeadache, n (%)259 (55)167 (48)92 (75)42 (70)0.0000.002Jaw claudication, n (%)112 (24)63 (18)49 (40)26 (43)0.0000.000Systemic manifestationsFever, n (%)57 (12)47 (13)10 (8)4 (7)0.120.20Constitutional syndrome, n (%)175 (37)132 (38)43 (35)20 (33)0.550.47PmR, n (%)284 (60)218 (62)66 (54)29 (48)0.0940.022Large-vessel involvement, n (%)254 (54)211 (60)43 (35)20 (33)0.0000.000ESR, mm/1st hour, median [IQR]32 [12-57]30 [11-54]34 [15-67]42 [12-67]0.220.28CRP (mg/dL), median [IQR]1.5 [0.5-3.4]1.4 [0.5-3.0]1.5 [0.4-4.7]1.5 [0.4-3.6]0.0420.30In the same line, the set of variables associated with PVL were headache, and jaw claudication. By contrast, polymyalgia rheumatica (PmR), and large-vessel involvement were protective factors (Figure 1). The AUC for this model was 0.77 (95%CI 0.71-0.83; p<0.0001).ConclusionHeadache, and jaw claudication seem to be associated with visual involvement in GCA, while large vessel involvement seems to be a protective factor. PmR also appears to be a protective factor for the development of PVL.References[1]Calderón-Goercke M, et al. Semin Arthritis Rheum. 2019; 49: 126-135. PMID: 30655091[2]Baalbaki H, et al. Clin Rheumatol. 2021; 40: 3207-3217. PMID: 33580374[3]González-Gay MA, et al. Arthritis Rheum. 1998; 41: 1497-1504. PMID: 9704651[4]Prieto-Peña D, et al. Semin Arthritis Rheum. 2019; 48: 720-727. PMID: 29903537[5]Martínez-Rodríguez I, et al. Semin Arthritis Rheum. 2018; 47: 530-537. PMID: 28967430AcknowledgementsTocilizumab in Giant Cell Arteritis Spanish Collaborative Group.Disclosure of InterestsLara Sanchez-Bilbao: None declared, Javier Loricera Speakers bureau: Roche, Novartis, UCB Pharma, Celgene, and Grünenthal, Clara Moriano: None declared, Santos Castañeda Speakers bureau: UAM-Roche, EPID- Future chair, Department of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., Iván Ferraz-Amaro: None declared, J. Narváez: None declared, Vicente Aldasoro: None declared, Olga Maiz: None declared, Rafael Melero: None declared, Ignacio Villa-Blanco: None declared, Paloma Vela-Casasempere: None declared, Susana Romero-Yuste: None declared, Jose Luis Callejas-Rubio: None declared, Eugenio de Miguel: None declared, E. Galíndez-Agirregoikoa: None declared, Francisca Sivera: None declared, Carlos Fernández-López: None declared, Carles Galisteo: None declared, Julio Sanchez-Martin: None declared, Monica Calderón-Goercke: None declared, J. Luis Hernández: None declared, Miguel A González-Gay Speakers bureau: Abbvie, Pfizer, Roche, Sanofi, Lilly, Celgene, and MSD., Grant/research support from: AbbVie, MSD, Jansen, and Roche,, Ricardo Blanco Speakers bureau: Abbvie, Pfizer, Roche, Bristol-Myers, Lilly, Janssen, and MSD., Grant/research support from: Abbvie, MSD, and Roche

We disclose the use of a suitable pair of phase-only masks for generating sinusoidal phase gratings, or sinusoidal phase zone plates, with tunable optical path delays. We show that these gratings can have either 1-D structure or a 2-D radial structure. Full Text: PDF ReferencesB. Berge and J. Peseux, "Variable focal lens controlled by an external voltage: An application of electrowetting", Eur. Phys. J. E 3, 159-163 (2000). CrossRef H. W. Ren, Y. H. Fan, S. Gauza, and S. T. Wu, "Tunable-focus flat liquid crystal spherical lens", Appl. Phys. Lett. 84, 4789-4791 (2004). CrossRef T. Martinez, D. V. Wick, D. M. Payne, J. T. Baker, and S. R. Restaino, "Non-mechanical zoom system", Proc. SPIE 5234, 375-378 (2004). CrossRef D. Y. Zhang, N. Justis, and Y. H. Lo, "Fluidic adaptive zoom lens with high zoom ratio and widely tunable field of view", Opt. Commun. 249, 175-182 (2005). CrossRef B. H. W. Hendriks, S. Kuiper, M. A. J. Van As, C. A. Renders and T. W. Tukker, "Electrowetting-Based Variable-Focus Lens for Miniature Systems", Opt. Rev. 12, 255-259 (2005). CrossRef M. Duocastella and C. B. Arnold, "Enhanced depth of field laser processing using an ultra-high-speed axial scanner", Appl. Phys. Lett. 102, 06113-1--06113-3 (2013). CrossRef Jorge Ojeda-Casta-eda, José Enrique A. Landgrave and Cristina M. Gómez-Sarabia, "Conjugate phase plate use in analysis of the frequency response of imaging systems designed for extended depth of field", Appl. Opt. 47, E99 (2008). CrossRef A.W. Lohmann, British Patent 998, 191 (May 29, 1964).A.W. Lohmann, Republic Française 1, 398, 351 (June 10, 1964).A.W. Lohmann, Italy Patent 727, 848 (June 19, 1964).A.W Lohmann, "A New Class of Varifocal Lenses", Appl. Opt. 9, 1669 (1970). CrossRef L.W. Alvarez, U.S. patent 3,305,294 (21 February 1967).L.W. Alvarez , W. E. Humphrey, U.S. patent 3,507,565 (21 April, 1970).L.W. Alvarez, J. Am. Optometric Assoc. 49, 24 (1978).S. Bernet and M. Ritsch-Marte, U.S. patent application 20100134869 A1 (June 3, 2010).Jorge Ojeda-Castaneda, S. Ledesma, and C. M. Gómez-Sarabia, "Tunable apodizers and tunable focalizers using helical pairs", Phot. Lett. Poland 5, 20 (2013). CrossRef J. Ojeda-Casta-eda, C. M. Gómez-Sarabia, and S. Ledesma, "Novel free-form optical pairs for tunable focalizers", J. Opt. 43, 85 (2014). CrossRef J. Ojeda-Castaneda, A. L. Barragán-Chávez, and C. M. Gómez-Sarabia, "Aberration generators in tandem", Phot. Lett. Poland 7, 8 (2015). CrossRef Adolf W. Lohmann and Donald A. Silva, "An interferometer based on the Talbot effect", Optics Comm. 2, 413 (1971). CrossRef S. Yokozeki and T. Suzuki, "Shearing Interferometer Using the Grating as the Beam Splitter", Appl. Opt. 10, 1575 (1971). CrossRef Jason Geng, "Structured-light 3D surface imaging: a tutorial", Adv. Opt. Phot. 3, 128 (2011). CrossRef Jorge Ibarra and J. Ojeda-Casta-eda, "Talbot interferometry: a new geometry", Opt. Commun. 96, 294 (1993). CrossRef J. Ojeda-Castaneda, C.M. Gómez-Sarabia, S. Ledesma, "Novel zoom systems using a vortex pair", Asian J. Phys. 23, 415 (2014). DirectLink J. Ojeda-Castaneda, C.M. Gómez-Sarabia, S. Ledesma, Asian J. Phys. 23, 535 (2014). DirectLink J. Ojeda-Casta-eda and Cristina M. Gómez-Sarabia, "Nonconventional optical systems using varifocal lenses", Phot. Lett. Poland 7, 14 (2015). CrossRef

The existence of exact coherent structures in stably stratified plane Couette flow (gravity perpendicular to the plates) is investigated over Reynolds–Richardson number ($Re$–$Ri_{b}$) space for a fluid of unit Prandtl number $(Pr=1)$ using a combination of numerical and asymptotic techniques. Two states are repeatedly discovered using edge tracking – EQ7 and EQ7-1 in the nomenclature of Gibson & Brand (J. Fluid Mech., vol. 745, 2014, pp. 25–61) – and found to connect with two-dimensional convective roll solutions when tracked to negative $Ri_{b}$ (the Rayleigh–Bénard problem with shear). Both these states and Nagata’s (J. Fluid Mech., vol. 217, 1990, pp. 519–527) original exact solution feel the presence of stable stratification when $Ri_{b}=O(Re^{-2})$ or equivalently when the Rayleigh number $Ra:=-Ri_{b}Re^{2}Pr=O(1)$. This is confirmed via a stratified extension of the vortex wave interaction theory of Hall & Sherwin (J. Fluid Mech., vol. 661, 2010, pp. 178–205). If the stratification is increased further, EQ7 is found to progressively spanwise and cross-stream localise until a second regime is entered at $Ri_{b}=O(Re^{-2/3})$. This corresponds to a stratified version of the boundary region equations regime of Deguchi, Hall & Walton (J. Fluid Mech., vol. 721, 2013, pp. 58–85). Increasing the stratification further appears to lead to a third, ultimate regime where $Ri_{b}=O(1)$ in which the flow fully localises in all three directions at the minimal Kolmogorov scale which then corresponds to the Osmidov scale. Implications for the laminar–turbulent boundary in the ($Re$–$Ri_{b}$) plane are briefly discussed.

We develop the BRST approach to construct the general off-shell local Lorentz covariant cubic interaction vertices for irreducible massless and massive higher spin fields on d-dimensional Minkowski space. We consider two different cases for interacting higher spin fields: with one massive and two massless; two massive, both with coinciding and with different masses and one massless field of spins s1,s2,s3. Unlike the previous results on cubic vertices we extend our earlier result in (Buchbinder, I.L.; et al. Phys. Lett. B 2021, 820, 136470) for massless fields and employ the complete BRST operator, including the trace constraints, which is used to formulate an irreducible representation with definite integer spin. We generalize the cubic vertices proposed for reducible higher spin fields in (Metsaev, R.R. Phys. Lett. B 2013, 720, 237) in the form of multiplicative and non-multiplicative BRST-closed constituents and calculate the new contributions to the vertex, which contains the additional terms with a smaller number of space-time derivatives. We prove that without traceless conditions for the cubic vertices in (Metsaev, R.R. Phys. Lett. B 2013, 720, 237) it is impossible to provide the noncontradictory Lagrangian dynamics and find explicit traceless solution for these vertices. As the examples, we explicitly construct the interacting Lagrangians for the massive spin of the s field and the massless scalars, both with and without auxiliary fields. The interacting models with different combinations of triples higher spin fields: massive spin s with massless scalar and vector fields and with two vector fields; massless helicity λ with massless scalar and massive vector fields; two massive fields of spins s, 0 and massless scalar is also considered.

Can Gio mangrove forest (CGM) is located downstream of Ho Chi Minh City (HCMC), situated between an estuarine system of Dong Nai - Sai Gon river and a part of Vam Co river. The CGM is the largest restored mangrove forest in Vietnam and the UNESCO’s Mangrove Biosphere Reserve. The CGM has been gradually facing to numeric challenges of global climate change, environmental degradation and socio-economic development for the last decades. To evaluate sediment quality in the CGM, we collected 13 cores to analyze for sediment grain size, organic matter content, and trace element concentration of Cd, Cr, Cu, Ni, Pb, Zn. Results showed that trace element concentrations ranged from uncontaminated (Cd, Cu, and Zn) to very minor contaminated (Cr, Ni, and Pb). The concentrations were gradually influenced by suspended particle size and the mangrove plants.ReferencesAnh M.T., Chi D.H., Vinh N.N., Loan T.T., Triet L.M., Slootenb K.B.-V., Tarradellas J., 2003. 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The hydrogen fuel cell is a promising technology that supports the development of sustainable energy systems and zero emission vehicles. One of the key technical challenges for the use of fuel cells in the transportation sector is the high durability requirements 1–3. One of the key components that control the overall life time of a hydrogen fuel cell is the ionomer membrane that conducts the protons and allows the separation between the anode and the cathode. During fuel cell operation, the membrane is subjected to two categories of degradation: mechanical and chemical. These degradations lead to reduction in the performance, crossover of reactants between anode and cathode and ultimately total failure of the fuel cell. The mechanical degradation occurs when the membrane swells and shrinks under the variation of the local hydration level. This leads to fatigue of the ionomer structure and ultimately irreversible damage. However, under pure mechanical degradation the damage takes a very long time to occur 4,5. Sadeghi et al. 5 observed failure of the membrane after 20,000 of accelerated mechanical stress testing. This translates into a longer lifetime in comparison to what is observed in field operation 6. The chemical degradation on the other hand is caused by the presence of harmful chemicals such as OH radicals that attack the side chains and the main chains of the ionomer 7,8. Such attacks weaken the structural integrity of the membrane and make it prone to severe mechanical damage. Hence understanding the effect of combining both categories of membrane degradation is the key to accurate prediction of the time to failure of the fuel cell. In this work we propose a novel model that represents accurately the structural properties of the membrane and couples the chemical and the mechanical degradations to estimate when the ultimate failure is initiated. The model is based on a network of agglomerated fibrils corresponding to the basic building block of the membrane structure 9–11. The mechanical and chemical properties are defined for each fibril and probability functions are used to evaluate the likelihood of a fibril to break under certain operating conditions. The description of the fundamentals behind the approach will be presented. Two set of simulations will be presented and discussed. The first one corresponding to standard testing scenarios that were used to validate the model. The second set of results will highlight the impact of coupling both degradation mechanisms on the estimation of the failure initiation time. The main strengths of the model and the future development will be discussed as well. T. Sinigaglia, F. Lewiski, M. E. Santos Martins, and J. C. Mairesse Siluk, Int. J. Hydrogen Energy, 42, 24597–24611 (2017). T. Jahnke et al., J. Power Sources, 304, 207–233 (2016). P. Ahmadi and E. Kjeang, Int. J. Energy Res., 714–727 (2016). X. Huang et al., J. Polym. Sci. Part B Polym. Phys., 44, 2346–2357 (2006). A. Sadeghi Alavijeh et al., J. Electrochem. Soc., 162, F1461–F1469 (2015). N. Macauley et al., J. Power Sources, 336, 240–250 (2016). K. H. Wong and E. Kjeang, J. Electrochem. Soc., 161, F823–F832 (2014). K. H. Wong and E. Kjeang, ChemSusChem, 8, 1072–1082 (2015). P.-É. A. Melchy and M. H. Eikerling, J. Phys. Condens. Matter, 27, 325103–6 (2015). J. A. Elliott et al., Soft Matter, 7, 6820 (2011). L. Rubatat, G. Gebel, and O. Diat, Macromolecules, 37, 7772–7783 (2004).

In this paper, heavy metal oxide glasses co-doped with erbium and holmium ions have been synthesized. Glass composition, based on the bismuth and germanium oxides, has been selected in terms of high thermal stability (delta T = 125 °C), high refractive index (n = 2.19) and low maximum phonon energy (hvmax = 724 cm-1). Up-conversion luminescence spectra under the 980 nm laser diode excitation have been observed as a result of radiative transitions within the quantum energy level structures of Er3+ and Ho3+ ions. Optimization of rare earth ions content has been conducted, the highest emission intensity in the visible wavelength range has been observed in glass co-doped with molar concentration 0.5 Er2O3 / 0.5 Ho2O3. Full Text: PDF ReferencesF. Zhang, Z. Bi, A. Huang, Z. Xiao, "Visible luminescence properties of Er3+?Pr3+ codoped fluorotellurite glasses", Opt. Materials 41, 112 (2014). CrossRef S. Li, S. Ye, T. Liu, H. Wang, D. Wang, "Enhanced up-conversion emissions in ZnO-LiYbO2:RE3+ (RE = Er or Ho) hybrid phosphors through surface modification", J. All. Comp. 658, 85 (2016). CrossRef J. Fu, X. Zhang, Z. Chao, Z. Li, J. Liao, D. Hou, H. Wen, X. Lu, X. Xie, "Enhanced upconversion luminescence of NaYF4:Yb, Er microprisms via La3+ doping", Opt. Laser Tech. 88, 280 (2017). CrossRef Y. Tian, R. Xu, L. Hu, J. Zhang, "2.7 ?m fluorescence radiative dynamics and energy transfer between Er3+ and Tm3+ ions in fluoride glass under 800 nm and 980 nm excitation", J. Quant. Spec. Rad. Tra. 113, 87 (2012). CrossRef M. Zhang, A. Yang, Y. Peng, B. Zhang, H. Ren, W. Guo, Y. Yang, C. Zhai, Y. Wang, Z. Yang, D. Tang, "Dy3+-doped Ga?Sb?S chalcogenide glasses for mid-infrared lasers", Mat. Res. Bul. 70, 55 (2015). CrossRef G. Yang, T. Li, "Broadband 1.53 ?m emission in Er3+-doped Ga-Bi-Pb-Ge heavy metal oxide glasses", J. Rare Earths 26, 924 (2008). CrossRef Y. Guo, Y. Tian, L. Zhang, L. Hu, J. Zhang, "Erbium doped heavy metal oxide glasses for mid-infrared laser materials", J. Non-Cryst. Solids 377, 119 (2013). CrossRef Z. Hou, Z. Xue, F. Li, M. Wang, X. Hu, S. Wang, "Luminescence and up-conversion mechanism of Er3+/Ho3+ co-doped oxyfluoride tellurite glasses and glass?ceramics", J. All. Comp. 577, 523 (2013). CrossRef X. Li, Q. Nie, S. Dai, T. Xu, L. Lu, X. Zhang, "Energy transfer and frequency upconversion in Ho3+/Yb3+ co-doped bismuth-germanate glasses", J. All. Comp. 454, 510 (2008). CrossRef S.S. Rojas, J.E. De Souza, M.R.B. Andreeta, A.C. Hernandes, "Influence of ceria addition on thermal properties and local structure of bismuth germanate glasses", J. Non-Cryst. Solids 356, 2942 (2010). CrossRef M.S. Ebrahim, Irina, Mid-infrared coherent sources and applications, Springer (2008). CrossRef T. Ragin, J. Zmojda, M. Kochanowicz, P. Miluski, P. Jelen, M. Sitarz, D. Dorosz, "Enhanced mid-infrared 2.7 ?m luminescence in low hydroxide bismuth-germanate glass and optical fiber co-doped with Er3 +/Yb3 + ions", J. Non-Cryst. Solids 457, 169 (2017). CrossRef K. Biswas, A.D. Sontakke, R. Sen, K. Annapurna, "Enhanced 2 ?m broad-band emission and NIR to visible frequency up-conversion from Ho3+/Yb3+ co-doped Bi2O3?GeO2?ZnO glasses", Spectr. Acta. Part A, Mol. Biomol. Spectr. 112, 301-308 (2013). CrossRef R.S. Romaniuk, D. Dorosz, J. Żmojda, M. Kochanowicz, W. Mazerski, "Upconversion luminescence in tellurite glass codoped with Yb3+/Ho3+ ions", Proc. of SPIE 8903, 890307 (2013). CrossRef

BACKGROUND: Perinatal transmission of hepatitis B virus (HBV) can occur despite postexposure prophylaxis (PEP). Recent literature suggests that antiviral treatment during pregnancy when maternal HBV DNA levels are elevated can further decrease vertical transmission. However, HBV DNA screening is not routinely performed antenatally.OBJECTIVE: To determine the rates of HBV prevalence and perinatal transmission in an antenatal cohort.METHODS: A retrospective review of public health records (December 2008 to December 2010) was performed for both mothers and newborns.RESULTS: A total of 725 mother-infant pairs were included. Of these, 574 of 715 (80%) women had antenatal hepatitis B e antigen (HBeAg) testing performed, and 127 of 574 (22%) were HBeAg positive (HBeAg+). Of babies born to hepatitis B surface antigen-positive (HBsAg+) mothers, only 573 of 725 (79%) received complete PEP. In addition, 172 of 725 (24%) infants did not receive post-PEP blood testing or were lost to follow-up. Of the 552 infants with results available, seven cases (1.3%) of mother-to-child HBV transmission were observed, six of which involved infants born to HBeAg+ women.CONCLUSIONS: Our findings suggest that routine HBeAg screening could identify a subset of mother-infant pairs among HBsAg+ pregnant women who are at higher risk for vertical HBV transmission. Determination of viral load in expectant HBeAg+ mothers may provide more precise insight into HBV transmission to their infants.

This study aims to determine the development of scientific publications, mapping the scope and theme of publications related to obesity in early childhood published in Scopus-indexed journals from 2013-2023. This study uses the Scopus database which is retrieved using the publish or perish application. From the results of data extraction, 200 articles were obtained with keywords in the article titled Childhood Obesity. This research uses keyword co-occurrence analysis to identify and explore the main fields and topics that appear in publications. The application used to analyze the data is Vos Viewer. Based on the results of the analysis, 7 clusters were obtained. This study provides information to researchers, especially researchers in Indonesia about publication trends related to Childhood obesity. It is hoped that this research can be a foundation for further research, scientific development, and implementation in the fields of early childhood, health, and physical education. Keywords: childhood obesity, early childhood education, bibliometrics. References: An, R. (2020). Projecting the impact of the coronavirus disease-2019 pandemic on childhood obesity in the United States: A microsimulation model. Journal of Sport and Health Science, 9(4), 302–312. https://doi.org/10.1016/j.jshs.2020.05.006 Biro, F. M., & Wien, M. (2010). Childhood obesity and adult morbidities. The American Journal of Clinical Nutrition, 91(5), 1499S-1505S. Cunningham, S. A., Kramer, M. R., & Narayan, K. M. V. (2014). Incidence of Childhood Obesity in the United States. New England Journal of Medicine, 370(5), 403–411. https://doi.org/10.1056/nejmoa1309753 Famelia, R., Tsuda, E., Bakhtiar, S., & Goodway, J. D. (2018). Relationships among perceived and actual motor skill competence and physical activity in Indonesian preschoolers. Journal of Motor Learning and Development, 6, S403–S423. https://doi.org/10.1123/jmld.2016-0072 Gao, Z., Zeng, N., Pope, Z. C., Wang, R., & Yu, F. (2019). Effects of exergaming on motor skill competence, perceived competence, and physical activity in preschool children. Journal of Sport and Health Science, 8(2), 106–113. https://doi.org/10.1016/j.jshs.2018.12.001 Genin, P. M., Lambert, C., Larras, B., Pereira, B., Toussaint, J. F., Baker, J. S., Tremblay, A., Thivel, D., & Duclos, M. (2021). How did the COVID-19 confinement period affect our physical activity level and sedentary behaviors? Methodology and first results from the French national ONAPS survey. Journal of Physical Activity and Health, 18(3), 296–303. https://doi.org/10.1123/JPAH.2020-0449 Giles, L. C., Whitrow, M. J., Davies, M. J., Davies, C. E., Rumbold, A. R., & Moore, V. M. (2015). Growth trajectories in early childhood, their relationship with antenatal and postnatal factors, and development of obesity by age 9 years: Results from an Australian birth cohort study. International Journal of Obesity, 39(7), 1049–1056. https://doi.org/10.1038/ijo.2015.42 Huang, S. Y., Hogg, J., Zandieh, S., & Bostwick, S. B. (2012). A ballroom dance classroom program promotes moderate to vigorous physical activity in elementary school children. American Journal of Health Promotion, 26(3), 160–165. https://doi.org/10.4278/ajhp.090625-QUAN-203 Ji, C. Y., & Cheng, T. O. (2008). Prevalence and geographic distribution of childhood obesity in China in 2005. In International journal of cardiology (Vol. 131, Issue 1, pp. 1–8). Elsevier. Jia, P., Xue, H., Zhang, J., & Wang, Y. (2017). Time trend and demographic and geographic disparities in childhood obesity prevalence in China—evidence from twenty years of longitudinal data. International Journal of Environmental Research and Public Health, 14(4). https://doi.org/10.3390/ijerph14040369 Kawuki, J., Ghimire, U., Papabathini, S. S., Obore, N., & Musa, T. H. (2021). A bibliometric analysis of childhood obesity research from China indexed in Web of Science. Journal of Public Health and Emergency, 5(February). https://doi.org/10.21037/jphe-20-95 Kesehatan RI, K. (2021). Epidemi Obesitas. In Epidemi Obesitas (pp. 1–8). Milliken, S., Allen, R. M., & Lamont, R. F. (2019). The role of antimicrobial treatment during pregnancy on the neonatal gut microbiome and the development of atopy, asthma, allergy and obesity in childhood. Expert Opinion on Drug Safety, 18(3), 173–185. Min, J., Fang Yan, A., & Wang, Y. (2018). Mismatch in Children’s Weight Assessment, Ideal Body Image, and Rapidly Increased Obesity Prevalence in China: A 10‐Year, Nationwide, Longitudinal Study. Obesity, 26(11), 1777–1784. Ogden, C. L., Carroll, M. D., Kit, B. K., & Flegal, K. M. (2014a). Prevalence of childhood and adult obesity in the United States, 2011-2012. Jama, 311(8), 806–814. https://doi.org/10.1001/jama.2014.732 Ogden, C. L., Carroll, M. D., Kit, B. K., & Flegal, K. M. (2014b). Prevalence of childhood and adult obesity in the United States, 2011-2012. Jama, 311(8), 806–814. https://doi.org/10.1001/jama.2014.732 Osunsan, O. K., Ijjo, A. T., Mugisha, J. F., Samuel, P., & Muhwezi, M. (2022). Publish or Perish’: A Systematic Review. Journal of Social Sciences and Management, 1. Ranjani, H., Mehreen, T. S., Pradeepa, R., Anjana, R. M., Garg, R., Anand, K., & Mohan, V. (2016). Epidemiology of childhood overweight & obesity in India: A systematic review. In Indian Journal of Medical Research (Vol. 143, Issue FEBRUARY, pp. 160–174). https://doi.org/10.4103/0971-5916.180203 Reyes-Olavarría, D., Latorre-Román, P. Á., Guzmán-Guzmán, I. P., Jerez-Mayorga, D., Caamaño-Navarrete, F., & Delgado-Floody, P. (2020). Positive and negative changes in food habits, physical activity patterns, and weight status during covid-19 confinement: Associated factors in the chilean population. International Journal of Environmental Research and Public Health, 17(15), 1–14. https://doi.org/10.3390/ijerph17155431 Russell, C. G., & Russell, A. (2019). A biopsychosocial approach to processes and pathways in the development of overweight and obesity in childhood: Insights from developmental theory and research. Obesity Reviews, 20(5), 725–749. Simmonds, M., Llewellyn, A., Owen, C. G., & Woolacott, N. (2016). Predicting adult obesity from childhood obesity: A systematic review and meta-analysis. Obesity Reviews, 17(2), 95–107. https://doi.org/10.1111/obr.12334 World Health Organisation. (2021). WHO releases guidelines to address overweight and obesity in. Zhang, X., Zhang, F., Yang, J., Yang, W., Liu, W., Gao, L., Peng, Z., & Wang, Y. (2018). Prevalence of overweight and obesity among primary school-aged children in Jiangsu Province, China, 2014-2017. PLoS One, 13(8), e0202681. World Health Organisation. (2021). WHO releases guidelines to address overweight and obesity in.

Abstract 60 Background: Infections by certain viruses, bacteria, and parasites have been identified as risk factors for some cancers. In 2008, there were 12.7 million new cancer cases worldwide. About 2 million of these new cases were attributable to infections, which represent 16.1% of new cancer cases. The majority of these cancers occurred in less-developed regions of the world, where the Population Attributable Fraction (PAF) was estimated to be 23%. We carried out this study to evaluate the numbers of cancers in Nigeria from 2012-2014 that are attributable to infections using data from Population Based Cancer Registries (PBCR) in Nigeria. Methods: We considered cancers associated with Epstein-Barr virus (EBV), Human Papilloma Virus (HPV), Hepatitis B and C Virus (HBV/HCV), Human Immunodeficiency Virus and Human Herpes Virus 8 (HIV/HHV8), Helicobacter pylori, and Schistosoma haematobium that have been classified as oncogenic by IARC. We obtained data on the infection-associated cancers from registry databases of 3 PBCRs in Nigeria: Abuja, Enugu, and Calabar cancer registries. We used PAF for infectious agents associated cancers in developing countries, which were calculated using prevalence data and relative risk estimates in previous studies: EBV and Nasopharyngeal (90%), and Hodgkin's Lymphoma (80%); HPV and Cervical (100%), Vulval and Vaginal (40%), Anal (90%) and Oropharyngeal cancer (12%) in women; Penile (40%), Anal (90%) and Oropharyngeal cancer (12%) in men; HBV/HCV and Liver (92%), HIV/HHV8 and Kaposi sarcoma (100%), Non Hodgkin Lymphoma (100%); H. pylori and stomach (74%) and S. haematobium and Bladder cancer (56.6%). Results: The 3 PBCRs reported 4,861 cancer cases from 2012-2014: 1,875 male cases and 2,986 female cases. There were 412 infection-associated cancers in males accounting for 22% of total cancers in males, and 351 (85%) of these were attributable to infections. In females, there were 727 infection-associated cancers accounting for 24% of total cancers in females, and 674 (93%) of these were attributable to infections. Cancers of the Cervix (n=430), Liver (n=152), and Non-Hodgkin's Lymphoma (n=129) were the most common infection-associated cancers in both sexes. The most common infectious agents associated with cancers were HPV (n=453), HIV/HHV8 (n=199), HBV/HCV (n=143) and EBV (n=125). Conclusion: Our findings suggest that 85% of infection-associated cancers in males and 93% infection-associated cancers in females in Nigeria can be prevented with vaccination, safer risk behaviors, or anti-infective treatments. AUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST: Michael Kolawole Odutola No relationship to disclose Elima Jedy-Agba No relationship to disclose Emmanuel Oga No relationship to disclose Festus Igbinoba Travel, Accommodations, Expenses: AstraZeneca Theresa Otu No relationship to disclose Emmanuel Ezeome Honoraria: Roche Travel, Accommodations, Expenses: Roche Ima-Obong Ekanem No relationship to disclose Ramatu Hassan No relationship to disclose Clement Adebamowo Speakers' Bureau: Merck

ABSTRAK Pesatnya perkembangan perbankan syariah di Indonesia menimbulkan tantangan baru bagi bank syariah untuk lebih mendiversifikasi kegiatannya. Penelitian ini bermaksud untuk menganalisis dampak diversifikasi dan karakteristik bank pada profitabilitas bank umum syariah di Indonesia tahun 2015-2019 secara parsial maupun simultan. Diversifikasi diproksikan dengan diversifikasi pembiayaan berdasarkan akad dan diversifikasi pendapatan yang diukur menggunakan 1 - HHI (Herfindahl-Hirschman Index), sedangkan karakteristik bank diproksikan dengan non-performing financing dan ukuran bank. Menggunakan pendekatan kuantitatif dengan metode regresi data panel. Hasil menunjukkan secara parsial diversifikasi pembiayaan dan risiko pembiayaan berdampak signifikan negatif, ukuran bank berdampak positif signifikan, sedangkan diversifikasi pendapatan tidak berdampak signifikan terhadap profitabilitas BUS di Indonesia. Secara simultan diversifikasi dan karakteristik bank berpengaruh signifikan terhadap profitabilitas BUS di Indonesia. Kata Kunci: Profitabilitas, diversifikasi pembiayaan, diversifikasi pendapatan, risiko pembiayaan, ukuran bank. ABSTRACT The rapid development of Islamic banking in Indonesia creates a new challenge for sharia banks to diversify. This study aims to investigate the impact of diversification and bank characteristics on the profitability of sharia commercial banks in Indonesia in 2015-2019 partially and simultaneously. In this study, diversification was proxied by financing diversification based on contracts and revenue diversification measured using 1 - HHI (Herfindahl-Hirschman Index), while bank characteristics were proxied by non-performing financing and bank size. Using a quantitative approach with panel data regression analysis. This study uses purposive sampling. The results show that partially, diversification and financing risk has a significant negative impact, bank size has a significant positive impact, while income diversification does not have a significant impact on the profitability of sharia commercial banks in Indonesia. Simultaneously, diversification and bank characteristics have a significant effect on the profitability of sharia commercial banks in Indonesia. Keywords: Profitability, financing diversification, income diversification, financing risk, and bank size. DAFTAR PUSTAKA Al-Harbi, A. (2019). The determinants of conventional banks profitability in developing and underdeveloped OIC countries. Journal of Economics, Finance and Administrative Science, 24(47), 4–28. https://doi.org/10.1108/JEFAS-05-2018-0043 Alkhouri, R., & Arouri, H. (2018). The effect of diversification on risk and return in banking sector Evidence from the Gulf Cooperation Council countries. 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Analisis laporan keuangan. Bandung: CV. Alfabeta. Hermawan, D., & Fitria, S. (2019). Pengaruh CAR, NPF, FDR, dan BOPO terhadap profitabilitas dengan variabel kontrol size (Studi kasus pada PT. Bank Muamalat Indonesia periode 2010-2017). Diponegoro Journal of Management, 8, 59–68. Jumingan. (2006). Analisis laporan keuangan. Jakarta: PT. Bumi Aksara. Kabir, M. N., Worthington, A., & Gupta, R. (2015). Comparative credit risk in Islamic and conventional bank. Pacific Basin Finance Journal, 34, 327–353. https://doi.org/10.1016/j.pacfin.2015.06.001 Lam, T., & Nguyen, A. (2018). Diversification and bank efficiency in six ASEAN countries. Global Finance Journal, 37, 57–78. https://doi.org/10.1016/j.gfj.2018.04.004 Lee, S. P., & Isa, M. (2017). Determinants of bank margins in a dual banking system. Managerial Finance, 43(6), 630-645. https://doi.org/10.1108/MF-07-2016-0189 Lestari, W. A., Tanuatmodjo, H., & Cakhyaneu, A. (2020). Diversification of financing as an effort to increase profitability at Islamic comercial banks in Indonesia. Review of Islamic Economics and Finance, 3(1), 17–28. https://doi.org/10.20414/iqtishaduna.v11i1.1131 Masruroh, M. (2018). Diversifikasi pembiayaan sebagai upaya peningkatan profitabilitas di bank syariah. Al-Tijary, 3(2), 117. https://doi.org/10.21093/at.v3i2.1102 Menicucci, E., & Paolucci, G. (2016). The determinants of bank profitability: Empirical evidence from European banking sector. Journal of Financial Reporting and Accounting, 14(1), 86-115. https://doi.org/10.1108/JFRA-05-2015-0060 Meslier, C., Tacneng, R., & Tarazi, A. (2014). Is bank income diversification beneficial ? Evidence from an emerging economy. Journal of International Financial Markets, Institutions & Money, 31, 97–126. https://doi.org/10.1016/j.intfin.2014.03.007 Meyrantika, D. N., & Haryanto, M. (2017). 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Faktor-faktor yang mempengaruhi profitabilitas bank umum syariah di Indonesia. Jurnal Ecodemica, 2(1), 74-85. Samad, A. (2016). Are Islamic banks’ non-bank deposits shock resistant ? A comparison with conventional banks: Evidence from Bahrain. Journal of Applied Finance & Banking, 6(5), 107–117. Sari, I. A., & Wiratno, A., Suyono, E. (2014). Pengaruh strategi diversifikasi dan karakteristik perusahaan terhadap kinerja perusahaan. Journal of Auditing, Finance, and Forensic Accounting, 2(1), 13–22. https://doi.org/10.21107/jaffa.v2i1.757 Setiawan, R., & Shabrina, A. (2018). Diversifikasi pendapatan, kepemilikan pemerintah, kinerja dan risiko bank. Jurnal Dinamika Ekonomi & Bisnis, 15(1), 49–59. https://doi.org/10.34001/jdeb.v15i1.917 Siyoto, S., & Sodik, M. A. (2015). Dasar metodologi penelitian. Yogyakarta: Literasi Media Publishing. Tjiptono. (2001). Manajemen pemasaran dan analisa perilaku konsumen. Yogyakarta: BPFE. Trinugroho, I., Risfandy, T., & Doddy, M. (2018). Competition, diversification, and bank margins: Evidence from Indonesian Islamic rural banks. Borsa Istanbul Review, 18(4), 349-358. https://doi.org/10.1016/j.bir.2018.07.006 Wu, J., Chen, L., Chen, M., & Nam, B. (2020). Diversification, efficiency and risk of banks: Evidence from emerging economies. 45(December 2020). https://doi.org/10.1016/j.ememar.2020.100720 Yusuf, M. (2017). Dampak indikator rasio keuangan terhadap profitabilitas bank umum syariah di Indonesia. Jurnal Keuangan dan Perbankan, 13(2), 141–151.

ABSTRAK Pesatnya perkembangan perbankan syariah di Indonesia menimbulkan tantangan baru bagi bank syariah untuk lebih mendiversifikasi kegiatannya. Penelitian ini bermaksud untuk menganalisis dampak diversifikasi dan karakteristik bank pada profitabilitas bank umum syariah di Indonesia tahun 2015-2019 secara parsial maupun simultan. Diversifikasi diproksikan dengan diversifikasi pembiayaan berdasarkan akad dan diversifikasi pendapatan yang diukur menggunakan 1 - HHI (Herfindahl-Hirschman Index), sedangkan karakteristik bank diproksikan dengan non-performing financing dan ukuran bank. Menggunakan pendekatan kuantitatif dengan metode regresi data panel. Hasil menunjukkan secara parsial diversifikasi pembiayaan dan risiko pembiayaan berdampak signifikan negatif, ukuran bank berdampak positif signifikan, sedangkan diversifikasi pendapatan tidak berdampak signifikan terhadap profitabilitas BUS di Indonesia. Secara simultan diversifikasi dan karakteristik bank berpengaruh signifikan terhadap profitabilitas BUS di Indonesia. Kata Kunci: Profitabilitas, diversifikasi pembiayaan, diversifikasi pendapatan, risiko pembiayaan, ukuran bank. ABSTRACT The rapid development of Islamic banking in Indonesia creates a new challenge for sharia banks to diversify. This study aims to investigate the impact of diversification and bank characteristics on the profitability of sharia commercial banks in Indonesia in 2015-2019 partially and simultaneously. In this study, diversification was proxied by financing diversification based on contracts and revenue diversification measured using 1 - HHI (Herfindahl-Hirschman Index), while bank characteristics were proxied by non-performing financing and bank size. Using a quantitative approach with panel data regression analysis. This study uses purposive sampling. The results show that partially, diversification and financing risk has a significant negative impact, bank size has a significant positive impact, while income diversification does not have a significant impact on the profitability of sharia commercial banks in Indonesia. Simultaneously, diversification and bank characteristics have a significant effect on the profitability of sharia commercial banks in Indonesia. Keywords: Profitability, financing diversification, income diversification, financing risk, and bank size. DAFTAR PUSTAKA Al-Harbi, A. (2019). The determinants of conventional banks profitability in developing and underdeveloped OIC countries. Journal of Economics, Finance and Administrative Science, 24(47), 4–28. https://doi.org/10.1108/JEFAS-05-2018-0043 Alkhouri, R., & Arouri, H. (2018). The effect of diversification on risk and return in banking sector Evidence from the Gulf Cooperation Council countries. International Journal of Managerial Finance, 15(1), 100-128. https://doi.org/10.1108/IJMF-01-2018-0024 Azmat, S., Skully, M., & Brown, K. (2015). Can Islamic banking ever become Islamic? Pacific Basin Finance Journal, 34, 253–272. https://doi.org/10.1016/j.pacfin.2015.03.001 Bougatef, K., & Korbi, F. (2018). The determinants of intermediation margins in Islamic and conventional banks. Managerial Finance, 44(6), 704–721. https://doi.org/10.1108/MF-11-2016-0327 Brigham, E. F., & Houston, J. F. (2010). Dasar-dasar manajemen keuangan. Jakarta: Salemba Empat. Chowdhury, M. A. F., & Rasid, M. E. S. M. (2017). Determinants of performance of Islamic banks in GCC countries: Dynamic GMM approach. Advances in Islamic Finance, Marketing, and Management, 49–80. https://doi.org/10.1108/9781786358981 Elsas, R., Hackethal, A., & Holzhäuser, M. (2010). The anatomy of bank diversification. Journal of Banking and Finance, 34(6), 1274–1287. https://doi.org/10.1016/j.jbankfin.2009.11.024 Fahmi, I. (2017). Analisis laporan keuangan. Bandung: CV. Alfabeta. Hermawan, D., & Fitria, S. (2019). Pengaruh CAR, NPF, FDR, dan BOPO terhadap profitabilitas dengan variabel kontrol size (Studi kasus pada PT. Bank Muamalat Indonesia periode 2010-2017). Diponegoro Journal of Management, 8, 59–68. Jumingan. (2006). Analisis laporan keuangan. Jakarta: PT. Bumi Aksara. Kabir, M. N., Worthington, A., & Gupta, R. (2015). Comparative credit risk in Islamic and conventional bank. Pacific Basin Finance Journal, 34, 327–353. https://doi.org/10.1016/j.pacfin.2015.06.001 Lam, T., & Nguyen, A. (2018). Diversification and bank efficiency in six ASEAN countries. Global Finance Journal, 37, 57–78. https://doi.org/10.1016/j.gfj.2018.04.004 Lee, S. P., & Isa, M. (2017). Determinants of bank margins in a dual banking system. Managerial Finance, 43(6), 630-645. https://doi.org/10.1108/MF-07-2016-0189 Lestari, W. A., Tanuatmodjo, H., & Cakhyaneu, A. (2020). Diversification of financing as an effort to increase profitability at Islamic comercial banks in Indonesia. Review of Islamic Economics and Finance, 3(1), 17–28. https://doi.org/10.20414/iqtishaduna.v11i1.1131 Masruroh, M. (2018). Diversifikasi pembiayaan sebagai upaya peningkatan profitabilitas di bank syariah. Al-Tijary, 3(2), 117. https://doi.org/10.21093/at.v3i2.1102 Menicucci, E., & Paolucci, G. (2016). The determinants of bank profitability: Empirical evidence from European banking sector. Journal of Financial Reporting and Accounting, 14(1), 86-115. https://doi.org/10.1108/JFRA-05-2015-0060 Meslier, C., Tacneng, R., & Tarazi, A. (2014). Is bank income diversification beneficial ? Evidence from an emerging economy. Journal of International Financial Markets, Institutions & Money, 31, 97–126. https://doi.org/10.1016/j.intfin.2014.03.007 Meyrantika, D. N., & Haryanto, M. (2017). Analisis permodalan, penyaluran dana, diversifikasi pendapatan, NIM dan risiko kredit terhadap kinerja keuangan perbankan (Studi empiris BUSN yang terdaftar di BEI periode 2012-2015). Diponegoro Journal of Management, 6, 1–13. Moudud-Ul-Huq, S. (2019). Can BRICS and ASEAN-5 emerging economies benefit from bank diversification? Journal of Financial Regulation and Compliance, 27(1), 43–69. https://doi.org/10.1108/JFRC-02-2018-0026 Muhammad. (2016). Manajemen keuangan syariah: Analisis fiqh & keuangan. Yogyakarta: UPP STIM YKPN. Paltrinieri, A., Dreassi, A., Rossi, S., & Khan, A. (2020). Risk-adjusted profitability and stability of Islamic and conventional banks: Does revenue diversification matter ? Global Finance Journal, July 2018. https://doi.org/10.1016/j.gfj.2020.100517 Purnamandari, N. P. A. L., & Badera, D. N. (2015). Kemampuan prediksi rasio keuangan dan ukuran bank pada risiko gagal bank. E-Jurnal Akuntasi Universitas Udayana, 2(12), 172–187. Ristia, H. Y. (2018). Faktor-faktor yang mempengaruhi profitabilitas bank umum syariah di Indonesia. Jurnal Ecodemica, 2(1), 74-85. Samad, A. (2016). Are Islamic banks’ non-bank deposits shock resistant ? A comparison with conventional banks: Evidence from Bahrain. Journal of Applied Finance & Banking, 6(5), 107–117. Sari, I. A., & Wiratno, A., Suyono, E. (2014). Pengaruh strategi diversifikasi dan karakteristik perusahaan terhadap kinerja perusahaan. Journal of Auditing, Finance, and Forensic Accounting, 2(1), 13–22. https://doi.org/10.21107/jaffa.v2i1.757 Setiawan, R., & Shabrina, A. (2018). Diversifikasi pendapatan, kepemilikan pemerintah, kinerja dan risiko bank. Jurnal Dinamika Ekonomi & Bisnis, 15(1), 49–59. https://doi.org/10.34001/jdeb.v15i1.917 Siyoto, S., & Sodik, M. A. (2015). Dasar metodologi penelitian. Yogyakarta: Literasi Media Publishing. Tjiptono. (2001). Manajemen pemasaran dan analisa perilaku konsumen. Yogyakarta: BPFE. Trinugroho, I., Risfandy, T., & Doddy, M. (2018). Competition, diversification, and bank margins: Evidence from Indonesian Islamic rural banks. Borsa Istanbul Review, 18(4), 349-358. https://doi.org/10.1016/j.bir.2018.07.006 Wu, J., Chen, L., Chen, M., & Nam, B. (2020). Diversification, efficiency and risk of banks: Evidence from emerging economies. 45(December 2020). https://doi.org/10.1016/j.ememar.2020.100720 Yusuf, M. (2017). Dampak indikator rasio keuangan terhadap profitabilitas bank umum syariah di Indonesia. Jurnal Keuangan dan Perbankan, 13(2), 141–151.

Introduction: Influenza infection is a viral disease with significant morbidity and mortality during the cold months. Clinical presentation typically includes cough, fever, and pain. Influenza disease is hardly diagnosed only on the basis of clinical symptoms due to similar clinical presentation of other diseases such as a typical cold or other flu-like diseases. We evaluated patients with proven influenza who presented at an emergency department of internal medicine in a university hospital according to the clinical presentation and different age groups. Materials and Methods: From October 2017 to April 2018, 723 reverse transcription-polymerase chain reaction (RT-PCR) tests for influenza were performed in the emergency department on patients with suspected influenza diagnosed clinically. A total of 240 influenza-positive patients were retrospectively assessed for documented main symptoms, vital parameters, risk factors for an unfavorable course, hospitalization, and death. Results: The mean age of influenza patients was 65 years. Overall, 30 patients were aged 18 to 39 years, 48 patients 40 to 59 years, and 162 patients ⩾60 years. Influenza B in 168 (70%) was predominant to 72 influenza A (mostly H1N1). In only 30% of the patients all three typical symptoms (cough, fever, and headache/myalgia) were documented. Headache or myalgia (with 34%) was rather uncommon in influenza B. Sudden onset was cited in only 5.4%; 57% of all influenza patients were in hospital for a mean of 7.1 days, and 5.8% of all influenza patients died. Patients aged above 60 years had more risk factors, showed typical symptoms less frequently, and were hospitalized longer than younger patients (<60 and <40 years). Conclusions: At an emergency department of internal medicine, influenza-diseased patients are of higher age, show an increased number of comorbidities, and are more likely to have milder symptoms documented. Elderly patients with influenza have a higher hospitalization rate with a longer hospital stay as compared with younger patients.

ABSTRAK Penelitian ini bertujuan untuk mengetahui peran dari store image terhadap repurchase intention pada Karita Muslim Square Surabaya yang di mediasi dengan customer satisfaction. Sampel yang digunakan yaitu 131 responden yang pernah melakukan pembelian di Karita Muslim Square Surabaya. Pengujian menggunakan SEM-PLS dengan konstruk pertama yang menunjukkan hasil yang tidak valid, sehingga pengujian dilanjutkan dengan pengujian konstruk kedua dengan mengeliminasi beberapa indikator, sehingga hasil evaluasi menunjukkan bahwa antar variabel dalam konstruk secara langsung memiliki pengaruh yang positif signifikan. Sedangkan secara tidak langsung customer satisfaction menunjukkan hubungan yang positif signifikan dalam memediasi store image terhadap repurchase intention. Sehingga customer satisfaction memiliki peran partial mediation dalam peneltian ini. Penelitian ini diharapkan memiliki manfaat bagi perusahaan terkait maupun sejenis agar mampu melihat segala peluang yang ada disekitar dengan memanfaatkan setiap komponen maupun dimensi citra toko agar dapat dimanfaatkan secara maksimal untuk mencapai tujuan dari tiap-tiap perusahaan. Kata Kunci: Store Image, Customer satisfaction, Repurchase intention, Islamic Retail. ABSTRACT This study aims to determine the role of store image on repurchase intention at Karita Muslim Square Surabaya which is mediated by customer satisfaction. The sample used is 131 respondents who have purchased at Karita Muslim Square Surabaya. The test uses SEM-PLS with the first construct showing invalid results, so the test is continued with the second construct testing by eliminating several indicators, the evaluation results show that the variables in the construct directly have a significant positive effect. Meanwhile, customer satisfaction indirectly shows a significant positive relationship in mediating store image on repurchase intention. So customer satisfaction has a partial mediation role in this research. This research is expected to have benefits for related and similar companies so they are able to see all the opportunities that exist by utilizing every component and dimension of the store image so they can be utilized optimally to achieve the goals of each company. Keywords: Store Image, Customer satisfaction, Repurchase intention, Islamic retail. DAFTAR PUSTAKA Akter, S., & Ashraf, E. (2016). Factors affecting repurchase intention of customers: In the context of retail chain store industry in Bangladesh. European Journal of Business and Management, 8(32), 40–47. Bray, J. (2008). Consumer behaviour theory: Approaches and models. Unpublished Discussion paper. 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There is a lack of information about the methods used for bovine platelet-rich plasma (PRP)/platelet-rich gel (PRG) procurement, including information on platelet (PLT), white blood cell (WBC) in PRP, and growth factor release from PRG supernatants. The aims of this study were to compare and to correlate the PLT, WBC, transforming growth factor beta-1 (TGF-β1), and platelet-derived growth factor BB (PDGF-BB) concentrations in bovine whole blood, plasma, and four PRP layers and their respective PRG supernatants: A and B (obtained by a single centrifugation tube method at 720g/5 min) and C and D (obtained by a double centrifugation tube method, by using two centrifugation episodes at 720g/5 min). PLT and WBC counts were significantly higher in PRP-C, followed by whole blood, PRP-A, PRP-B, and PRP-D. TGF-β1 concentrations were significantly higher in PRG-B supernatants and its correspondent PRP-B lysate when compared to the other PRG supernatants and plasma. Supernatants from PRG-A, PRG-B, and PRG-D had equivalent TGF-β1 concentrations. PDGF-BB concentrations were not statistically different between the hemoderivatives. Significant Pearson correlations were noted between PLT counts and WBC counts (0.8) and between PLT counts and PLT distribution width (0.6). Further studies should be performed to assess the potential clinical applications of these PRPs.