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Samuthpongtorn, Chatpol, Long H. Nguyen, Olivia I. Okereke, Dong D. Wang, Mingyang Song, Andrew T. Chan und Raaj S. Mehta. „Consumption of Ultraprocessed Food and Risk of Depression“. JAMA Network Open 6, Nr. 9 (20.09.2023): e2334770. http://dx.doi.org/10.1001/jamanetworkopen.2023.34770.
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Khan, Yasmee, Arati Lalchandani und AC Gupta. „A Study Of Prevalence Of Chronic Kidney Disease In Patients With Metabolic Syndrome In Urban Population Attending A Tertiary Care Center In India: A Hospital-Based Prospective Cross-Sectional Observational Study“. Recent Advances in Biology and Medicine 8, Nr. 4 (27.10.2022): 1–7. http://dx.doi.org/10.18639/rabm.2022.9800027.
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The study aims to determine the prevalence of Chronic Kidney Disease (CKD) and its risk factors in patients with Metabolic Syndrome in a tertiary care center in India. It was a hospital-based prospective observational study where NCEP ATP III CRITERIA was used to diagnose patients with Metabolic Syndrome, and CKD was defined according to KDIGO Guidelines. Out of 172 patients with Metabolic Syndrome, CKD was seen in 52 patients, of which 29 were males and 23 were females, so the prevalence of CKD in Metabolic Syndrome patients was about 30.23%. (52/172) P Value = 0.0000204. In our study, the prevalence of hyperglycemia in CKD patients with Metabolic Syndrome was 24.41% (42/172) P Value = .0011. The prevalence of obesity was 19.18% (33/172) P Value = .00844. The prevalence of hypertension was 28.48% (49/172) P Value = 2.72. The prevalence of hypertriglyceridemia was 26.12% (45\172) P Value = 0.000002086. The prevalence of hyperglycemia, obesity, and hypertriglyceridemia was significantly high in males. The prevalence of CKD in Metabolic Syndrome is 30.23% which is quite high, and since the prevalence of CKD is rising in India, we need more studies to look into this aspect of Metabolic Syndrome.
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Albano, Domenico, Carmelo Messina, Angelo Gambino, Martina Gurgitano, Carmelo Sciabica, Giordano Remo Oliveira Pavan, Salvatore Gitto und Luca Maria Sconfienza. „Segmented lordotic angles to assess lumbosacral transitional vertebra on EOS“. European Spine Journal 29, Nr. 10 (11.08.2020): 2470–76. http://dx.doi.org/10.1007/s00586-020-06565-7.
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Abstract Purpose To test the vertical posterior vertebral angles (VPVA) of the most caudal lumbar segments measured on EOS to identify and classify the lumbosacral transitional vertebra (LSTV). Methods We reviewed the EOS examinations of 906 patients to measure the VPVA at the most caudal lumbar segment (cVPVA) and at the immediately proximal segment (pVPVA), with dVPVA being the result of their difference. Mann–Whitney, Chi-square, and ROC curve statistics were used. Results 172/906 patients (19%) had LSTV (112 females, mean age: 43 ± 21 years), and 89/172 had type I LSTV (52%), 42/172 type II (24%), 33/172 type III (19%), and 8/172 type IV (5%). The cVPVA and dVPVA in non-articulated patients were significantly higher than those of patients with LSTV, patients with only accessory articulations, and patients with only bony fusion (all p < .001). The cVPVA and dVPVA in L5 sacralization were significantly higher than in S1 lumbarization (p < .001). The following optimal cutoff was found: cVPVA of 28.2° (AUC = 0.797) and dVPVA of 11.1° (AUC = 0.782) to identify LSTV; cVPVA of 28.2° (AUC = 0.665) and dVPVA of 8° (AUC = 0.718) to identify type II LSTV; cVPVA of 25.5° (AUC = 0.797) and dVPVA of − 7.5° (AUC = 0.831) to identify type III–IV LSTV; cVPVA of 20.4° (AUC = 0.693) and dVPVA of − 1.8° (AUC = 0.665) to differentiate type II from III–IV LSTV; cVPVA of 17.9° (AUC = 0.741) and dVPVA of − 4.5° (AUC = 0.774) to differentiate L5 sacralization from S1 lumbarization. Conclusion The cVPVA and dVPVA measured on EOS showed good diagnostic performance to identify LSTV, to correctly classify it, and to differentiate L5 sacralization from S1 lumbarization.
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Akhtar, Kashif, Weiyu Wang, Ivica Djalovic, P. V. Vara Prasad, Guangxin Ren, Noor ul Ain, Muhammad Riaz, Yongzhong Feng, Gaihe Yang und Ronghui Wen. „Combining Straw Mulch with Nitrogen Fertilizer Improves Soil and Plant Physio-Chemical Attributes, Physiology, and Yield of Maize in the Semi-Arid Region of China“. Plants 12, Nr. 18 (19.09.2023): 3308. http://dx.doi.org/10.3390/plants12183308.
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Mulching and nitrogen (N) fertilization are the main drivers for sustainable crop production. The sole use of nitrogen fertilizer threatened both the physiology and production of maize in rain-fed areas. Therefore, we proposed that wheat straw mulching with N fertilization would increase maize yield by improving soil fertility, physiology, and nitrogen use efficiency. A two-year field study evaluated the effects of CK (control), N (nitrogen application at 172 kg ha−1), HS (half wheat straw mulch, 2500 kg ha−1), HS+N (half wheat straw, 2500 kg ha−1 plus 172 kg N ha−1), FS (full wheat straw, 5000 kg ha−1), and FS+N (full wheat straw, 5000 kg ha−1 plus 172 kg N ha−1) on maize growth, physiology, and biochemistry. Compared with the control, the FS+N treatment resulted in the increase of 56% photosynthetic efficiency, 9.6% nitrogen use efficiency, 60% nitrogen uptake, 80% soluble sugar, 59% starches, 48% biomass, and 29% grain yield of maize. In addition, the FS+N regime increased 47%, 42%, and 106% of soil organic carbon and available P and N content in comparison with the control. Maize grain and biomass yields were positively correlated with N uptake, photosynthesis, soil organic carbon, and soil available N and P contents. Conclusively, the use of wheat straw at 5000 kg ha−1, along with 172 kg N ha−1, is a promising option for building a sustainable wheat–maize cropping system to achieve optimal crop yield and improved plant and soil health in a semi-arid region of China.
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Bruchhaus Steinert, Helke. „Was hat die Liebe in der Paartherapie zu suchen?“ Familiendynamik 42, Nr. 03 (Juli 2017): 172–81. http://dx.doi.org/10.21706/fd-42-3-172.
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Hanamori, T., K. Hirota und N. Ishiko. „Receptive fields and gustatory responsiveness of frog glossopharyngeal nerve. A single fiber analysis.“ Journal of General Physiology 95, Nr. 6 (01.06.1990): 1159–82. http://dx.doi.org/10.1085/jgp.95.6.1159.
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Receptive fields and responsiveness of single fibers of the glossopharyngeal (IXth) nerve were investigated using electrical, gustatory (NaCl, quinine HCl, acetic acid, water, sucrose, and CaCl2), thermal, and mechanical stimulation of the single fungiform papillae distributed on the dorsal tongue surface in frogs. 172 single fibers were isolated. 58% of these fibers (99/172) were responsive to at least one of the gustatory stimuli (taste fibers), and the remaining 42% (73/172) were responsive only to touch (touch fibers). The number of papillae innervated by a single fiber (receptive field) was between 1 and 17 for taste fibers and between 1 and 10 for touch fibers. The mean receptive field of taste fibers (X = 6.6, n = 99) was significantly larger than that of touch fibers (X = 3.6, n = 73) (two-tailed t test, P less than 0.001). In experiments with natural stimulation of single fungiform papillae, it was found that every branch of a single fiber has a similar responsiveness. Taste fibers were classified into 14 types (Type N, Q, A, NA, NCa, NCaA, NCaW, NCaAW, NCaWS, NQ, NQA, NQAS, NQWarm, Multiple) on the basis of their responses to gustatory and thermal stimuli. The time course of the response in taste fibers was found to be characteristic of their types. For example, the fibers belonging to Type NQA showed phasic responses, those in Type NCa showed tonic responses, etc. These results indicate that there are several groups of fibers in the frog IXth nerve and that every branch of an individual fiber has a similar responsiveness to the parent fiber.
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Iannone, Giovanni, Clelia Tripaldi, Antonino Chindemi, Lorenzo Piscitelli, Antonio Mastrorocco, Silvano Palazzo und Luigi Esposito. „Long-Term Neuropsychological Outcome in Preterm Twins“. Scientific World JOURNAL 6 (2006): 899–907. http://dx.doi.org/10.1100/tsw.2006.175.
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Few long-term studies have yet described neuropsychological outcome in preterm twins. Our aim was to assess, by long-term evaluation, neuropsychological outcome in preterm twins in order to define a correct follow-up program. Our study was a cohort one, with an index and a comparison group. Neonatal medical records of all preterm newborns admitted to our centre between 1991 and 1997 were reviewed and selected patients were recalled. The sample population included two matched groups of children aged 6—12 years, 86 twins and 86 singletons, submitted to paediatric, neurological, psychological, and ophthalmological examinations. Inclusion criteria were twin pregnancy and gestational age 27—36 weeks for index group; same gestational age, but single pregnancy, for the comparison group. All children underwent paediatric and neuropsychiatric examinations, cognitive assessment, and psychological evaluation by standardized tests for screening of learning specific disorders and language difficulties, and finally, ophthalmological examination. In order to study their role in predicting neuropsychological outcome, we examined some perinatal prognostic factors by statistical analysis. Unfavourable neuropsychological outcome was observed in 55/172 (32%) children, with different prevalence in the two groups, 42/172 (24%) in twins and 13/172 (8%) in singletons. Statistical analysis performed for examined prognostic factors showed significant differences in neuropsychological outcome with regard only to gestational age < 32 weeks, low birth weight, intraventricular haemorrhage, and periventricular leukomalacia. The incidence of neuropsychological diseases in the two groups showed significant difference about language and learning difficulties. Our data suggest that preterm twins represent a particular high-risk category of premature babies, mostly regarding the risk of so-called “minimal brain dysfunction”, so a careful follow-up is recommended.
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Lorenzo-González, Cristina, Elena Atienza-Sánchez, David Reyes-Umpierrez, Priyathama Vellanki, Georgia M. Davis, Francisco J. Pasquel, Saumeth Cardona, Maya Fayfman, Limin Peng und Guillermo E. Umpierrez. „SAFETY AND EFFICACY OF DPP-4 INHIBITORS FOR THE MANAGEMENT OF HOSPITALIZED GENERAL MEDICINE AND SURGERY PATIENTS WITH TYPE 2 DIABETES“. Endocrine Practice 26, Nr. 7 (Juli 2020): 722–28. http://dx.doi.org/10.4158/ep-2019-0481.
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Objective: DPP-4 inhibitors (DPP-4i) have been shown to be effective for the management of inpatient diabetes. We report pooled data from 3 prospective studies using DPP-4i in general medicine and surgery patients with type 2 diabetes (T2D). Methods: We combined data from 3 randomized studies comparing DPP-4i alone or in combination with basal insulin or a basal-bolus insulin regimen. Medicine (n = 266) and surgery (n = 319) patients admitted with a blood glucose (BG) between 140 and 400 mg/dL, treated with diet, oral agents, or low-dose insulin therapy were included. Patients received DPP-4i alone (n = 144), DPP-4i plus basal insulin (n = 158) or basal-bolus regimen (n = 283). All groups received correctional doses with rapid-acting insulin for BG >140 mg/dL. The primary endpoint was differences in mean daily BG between groups. Secondary endpoints included differences in hypoglycemia and hospital complications. Results: There were no differences in mean hospital daily BG among patients treated with DPP-4i alone (170 ± 37 mg/dL), DPP-4i plus basal (172 ± 42 mg/dL), or basalbolus (172 ± 43 mg/dL), P = .94; or in the percentage of BG readings within target of 70 to 180 mg/dL (63 ± 32%, 60 ± 31%, and 64 ± 28%, respectively; P = .42). There were no differences in length of stay or complications, but hypoglycemia was less common with DPP-4i alone (2%) compared to DPP-4i plus basal (9%) and basal-bolus (10%); P = .004. Conclusion: Treatment with DPP-4i alone or in combination with basal insulin is effective and results in a lower incidence of hypoglycemia compared to a basal-bolus insulin regimen in general medicine and surgery patients with T2D. Abbreviations: BG = blood glucose; BMI = body mass index; CI = confidence interval; DPP-4i = dipeptidyl peptidase-4 inhibitors; HbA1c = hemoglobin A1c; OR = odds ratio; T2D = type 2 diabetes
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Sambyalova, A. Yu, T. A. Bairova, T. L. Manaenkova, A. V. Belskikh, Yu K. Plotnikova und L. V. Rychkov. „Virological failure of antiretroviral therapy and associated social and clinical factors in children and adolescents living with HIV“. Journal Infectology 14, Nr. 5 (31.12.2022): 51–59. http://dx.doi.org/10.22625/2072-6732-2022-14-5-51-59.
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According to the World Health Organization, sustained virological suppression of 90 % should be achieved among children and adolescents living with HIV / AIDS, which makes it important to assess the prevalence of virological failure of antiretroviral therapy. The aim of this study was to determine the prevalence of virological failure and the clinical factors associated with it, as well as therapeutic drug monitoring in groups divided by the viral load level among children and adolescents with HIV. Materials and Methods: A retrospective analysis of the medical records of 184 children and adolescents receiving antiretroviral therapy and registered at the Irkutsk Regional Center for the Prevention and Control of AIDS and Infectious Diseases, Irkutsk, was carried out. The study included 172 children aged 1-18 years with perinatal HIV infection. Patients were divided into groups depending on the level of viral load: group 1 – 21 patients with viral load > 1000 copies/ml of plasma, group 2 – 42 patients with viral load 50– 1000 copies/ml of plasma, group 3 – 109 patients with undetectable viral load (< 50 copies/ml). All patients underwent standard tests in accordance with clinical guidelines for the treatment of HIV infection in children, as well as therapeutic drug monitoring. Results. Against the background of ongoing antiretroviral therapy, a significant number of patients 21 / 172 (12,2 %) experienced virological failure. The proportion of children and adolescents with incomplete suppression of HIV replication is 42 / 172 (24,4 %). Statistically significant differences were obtained by changing the ART regimen (p = 0,031). In the first group, the proportion of patients who changed the therapy regimen is 7 / 21 (33,3 %), which is two times less than in the group with a zero viral load of 70 / 109 (64,2 %). There are differences in the proportion of children and adolescents with zero concentrations of ritonavir and lopinavir (p = 0,020 and p = 0,012) in the three compared groups. The distribution of patients with zero concentrations was as follows: for ritonavir in the first group 3 / 17 (17,6 %), in the second – 8/37 (21,6 %), in the third group – 4/80 (5 %); for lopinavir – 4/17 (23,5 %), 6/36 (16,7 %), 3/80 (3,8 %), respectively. Conclusion. This study demonstrates that the prevalence of virological failure among children and adolescents receiving ART remains high. To achieve sustained virological suppression in children and adolescents taking a protease inhibitor regimen, adherence to therapy must be increased. As one of the methods for assessing adherence, therapeutic drug monitoring can be used.
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Gorgoraptis, Nikos, Joanna Zaw-Linn, Claire Feeney, Carmen Tenorio Jimenez, Mari Niemi, Aysa Malik, Timothy Ham, David Baxter, Anthony Goldstone und David Sharp. „THE IMPACT OF TRAUMATIC BRAIN INJURY ON PATIENT-REPORTED PHYSICAL AND MENTAL HEALTH“. Journal of Neurology, Neurosurgery & Psychiatry 86, Nr. 11 (14.10.2015): e4.114-e4. http://dx.doi.org/10.1136/jnnp-2015-312379.26.
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Traumatic Brain Injury (TBI) is a major cause of disability, with staggering social consequences, but little is known on what determines the impact of TBI from the patient's perspective.In an audit of 240 patients (172 males, median age: 42 years, range: 20–89 years) who attended our multidisciplinary TBI clinic, we examined the impact of cognitive function, depression, sleep, history of substance abuse, age, injury severity (172 moderate-severe, 68 possible-mild TBI) and time since injury (median: 4 months, range: 20 days–28 years) on two patient-reported measures of quality of life: SF–36 Health Survey and Nottingham Health Profile (NHP).Worse outcomes in NHP and both Mental and Physical sub-scores of SF–36 were associated with poorer cognitive performance, as measured by ACE–R. Depression, examined using BDI–II, showed a strong negative correlation with both quality of life measures. Sleep-related symptoms were also strongly associated with worse patient-reported outcomes. Patients reported poorer outcomes in both SF-36 and NHP when examined at a later time since their injury, and this effect could not be attributed to older age.Impairments in cognition, mood and sleep following TBI may have a significant impact on patients' perception of their physical and mental well-being.
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MOTT, TAMÍ, MIGUEL TREFAUT RODRIGUES und MARCO ANTÔNIO DE FREITAS. „Amphisbaena uroxena Mott, Rodrigues, De Freitas and Silva 2008 (Squamata, Amphisbaenidae) shows sexual dimorphism in precloacal pores“. Zootaxa 3043, Nr. 1 (28.09.2011): 33. http://dx.doi.org/10.11646/zootaxa.3043.1.3.
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In 2008, Mott, Rodrigues, De Freitas and Silva (Journal of Herpetology 42: 172) described as a new species Amphisbaena uroxena, characterized among other features by the presence of conic tubercles concentrated in a circle on the dorsal surface of the tail, an unique feature among South American amphisbaenids. At that time, based only on the three specimens of the type series, all without precloacal pores, they speculated that the absence of pores could be a sex-based difference. In fact, in other amphisbaenid species, the absence of pores in females has been either reported (A. dubia and A. heathi, Vanzolini 2002; A.hiata, Montero & Céspedez 2002) or noticed (A. anaemariae, observed by TM).
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Rose, K., G. Turcatti, P. Graber, S. Pochon, P. O. Regamey, K. U. Jansen, E. Magnenat, N. Aubonney und J. Y. Bonnefoy. „Partial characterization of natural and recombinant human soluble CD23“. Biochemical Journal 286, Nr. 3 (15.09.1992): 819–24. http://dx.doi.org/10.1042/bj2860819.
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The purification to homogeneity of an active soluble 25 kDa fragment of CD23, produced in insect cells using the baculovirus expression system, is described. Peptide mapping and analysis by Edman degradation and mass spectrometry permitted partial characterization of the protein. A total of 165 out of 172 residues, including N-terminal and C-terminal regions, were mapped. The positions of the two disulphide bonds in the IgE-binding region were also determined: residue 110 is joined to residue 124, and residue 42 to residue 133. Natural CD23 25 kDa fragment was also analysed and found to possess the same disulphide bond arrangement. These results extend the previously noted sequence similarity with lectins to elements of secondary structure.
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Dedic Plavetic, Natalija, Katarina Čular, Dora Gudelj, Kristina Kaceljak, Marija Križić, Marina Popovic, Stela Bulimbašić, Maja Sirotković-Skerlev, Sanda Bubanović und Tajana Silovski. „Real-world comparison of the efficacy of three CDK4/6 inhibitors (CDK4/6i) in the first-line treatment of endocrine-sensitive advanced breast cancer (aBC): Single institution experience.“ Journal of Clinical Oncology 42, Nr. 16_suppl (01.06.2024): e13080-e13080. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e13080.
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e13080 Background: The combination of CDK4/6i and endocrine therapy (ET) is the standard of care in the first-line treatment of hormone receptor positive (HR+), HER2- aBC. In registrational studies, the progression-free survival (PFS) of all three CDK4/6i ranged from 23.8 to 28.12 months and overall survival (OS) from 53.9 to 66.8. In Croatia, both ribociclib and palbociclib were approved for clinical use in August 2018 and abemaciclib in November 2019. Methods: This retrospective study included patients with endocrine-sensitive HR+, HER2- aBC treated with aromatase inhibitor (AI) and CDK4/6i in the first-line setting between August 2018 and October 2023 at University Hospital Centre Zagreb. Ethics committee approval was obtained before the study was commenced. Patient demographics, clinical presentation, tumor characteristics and treatment data were collected. Real-world PFS (rwPFS) and OS analyses were done with the final data cut-off date of December 31, 2023, using type 1 right censoring. Data were analyzed using the Kaplan-Meier method. Results: Of the 274 patients treated with a combination of CDK4/6i and ET in the first-line setting, 172 with endocrine-sensitive tumors (98 de novo metastatic and 74 with treatment-free interval longer than 12 months) were eligible for the study, of which 41.86% (72/172) received ribociclib, 44.19% (76/172) palbociclib, and 13.95% (24/172) abemaciclib. Overall rwPFS was 48 months (95% CI:35-53). In the abemaciclib group, median rwPFS and OS were not reached in the follow-up period. The rwPFS was 48 (95% CI:27-53) for ribociclib and 47 (95% CI:30-49) for palbociclib. The overall OS was 62 months (95% CI:47-62). Median OS in the ribociclib group was 62 months (95% CI:40-62) and in the palbociclib group 52 (95% CI:42-54) months. Conclusions: The PFS and OS results for palbociclib and ribociclib in this retrospective real-world study correlate with results from randomized clinical trials, confirming some inferiority of palbociclib compared to ribociclib in the context of OS. Due to the later availability of the drug, larger sample size and longer follow-up will be needed to make definitive conclusions on the efficacy of abemaciclib.
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Saunders, Craig D. „LUKAN PARABLES OF RECKLESS LIBERALITY. By AmandaBrobst‐Renaud. New Testament Monographs 42. Sheffield: Sheffield Phoenix, 2021. Pp. xii + 172. Cloth, $80.00.“ Religious Studies Review 50, Nr. 1 (März 2024): 168. http://dx.doi.org/10.1111/rsr.16944.
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Singhal, Pankaj, und Shashikant Lele. „Intraperitoneal Chemotherapy for Ovarian Cancer: Where Are We Now?“ Journal of the National Comprehensive Cancer Network 4, Nr. 9 (Oktober 2006): 941–46. http://dx.doi.org/10.6004/jnccn.2006.0077.
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Patients with advanced epithelial ovarian cancer are conventionally treated with intravenous (IV) platinum- and taxane-based chemotherapy to try to eradicate residual disease after optimal cytoreductive surgery, resulting in a median overall survival of 49 months. The Gynecologic Oncology Group (GOG) conducted 3 large randomized, phase III clinical trials of intraperitoneal (IP) chemotherapy (GOG 104, 114, and 172) that clearly showed superior progression-free and overall survival with IP chemotherapy compared with IV chemotherapy. All 3 clinical trials investigated IP cisplatin, with the last one adding IP paclitaxel. The most recent study (GOG 172) resulted in a median survival of 66 months for patients in the IP arm versus 50 months for those in the IV arm. Fewer patients in the IP arm than in the IV arm completed all 6 treatment cycles (42% vs. 83%, respectively) because of the toxic effects of chemotherapy and IP catheter-related complications. Initially, patients in the IP arm reported significantly worse quality of life than those in the IV arm. However, at 12-month follow-up, the groups experienced no difference in quality of life, except that paresthesias were more likely to persist at moderate levels among patients in the IP arm. Based on these clinical trials, the National Cancer Institute issued a clinical announcement recommending that women with stage III ovarian cancer who undergo optimal surgical cytoreduction be considered for IP chemotherapy.
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Cavattoni, Irene, Enrico Morello, Elena Oldani, Tamara Intermesoli, Ernesta Audisio, Claudia Minotto, Elisabetta Terruzzi et al. „Outcome of Adult AML at First Relapse Following a Risk-Oriented Strategy: An Update of the Northern Italy Leukemia Group (NILG) Experience“. Blood 112, Nr. 11 (16.11.2008): 4385. http://dx.doi.org/10.1182/blood.v112.11.4385.4385.
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Abstract INTRODUCTION The impact on post-relapse survival of selected prognostic factors and salvage therapy (finalized to perform an allo-SCT) was retrospectively analyzed in 172 patients (patients) with relapsed non-APL AML, who had been initially treated with standard induction and risk-adapatiented consolidation. The aim was to identify factors associated with a better outcome at first relapse. METHODS All 172 patients were at first recurrence following consolidation of CR1 with high-dose Ara-C (HiDAC) multicycle therapy supported by blood stem cells (standard risk, as defined by mixed clinical-cytogenetic criteria) or allo-SCT in case of high-risk prognostic profile. Median age at relapse was 55 y (range 21–70). CR1 duration was <6 months in 50 patients (29%), ranging from 0.6 to 52,7 mo (median 9,1). High risk patients were 128/172 (74%) and 43/172 patients (25%) had an unfavourable cytogenetics (CG). One hundred-eleven patients (64%) received HiDAC and 24 (14%) an allo-SCT according to study design. RESULTS 140 patients (81%) received salvage treatment. The remaining 32 patients (19%) received palliation and all of them died. The median OS was 17.1 mo, with a 2yOS of 34%. Favorable prognostic factors identified by univariate analisys were: favourable or intermediate CG (p=0,007), standard risk category according to first line protocol (p=0.004), availibility of a HLA matched donor (p= 0.048), achievement of an early CR1(p=0,000), HiDAC as first line therapy(p=0,000), alloHSCT perfomed at relapse (p=0,000) and a DFS from CR1>12 mo (p=0,000). In multivariate analysis favourable or intermediate CG and DFS >12 mo were confirmed as independent prognostic factors (p=0,036 and p=0,001 respectively). Among the 140 patients, 50 received an allo-SCT following relapse (36%, group 1), and the remaining 90 (64%, group 2) received high dose chemotherapy alone (85), autologous SCT (2), or DLI (3, in case of previous alloSCT). Both groups were comparable regarding age >55 y, prior allo-SCT and risk class at diagnosis. After salvage therapy, 44 patients(88%) in the group 1 achieved CR2, compared to 26 patients (29%) in the group 2. The median duration of CR2 was 9 mo (range 2–64) and 3 mo (range 1–34) in group 1 and 2 respectively. NRM was 17/140: 12 patients (24%) in the allo-SCT group and 5 (6%) in group 2. The 2yOS was 57% and 23% respectively (p=0,000). Moreover, among 50 alloSCT patients, survival was affected by risk category at diagnosis: 2yOS of 19 (38%) standard risk patients was 83% compared to 42% in 31 high risk patients (62%) (p=0.01). This risk stratification has no impact on OS in the group 2. CONCLUSIONS DFS > 12 mo and standard risk category at diagnosis, according to NILG protocol, are the most important independent positive prognostic factors impacting OS of AML relapsed patients. The availibility of a HLA matched donor and a subsequent intensification with alloSCT may offer substantial salvage rates and its outcome is affected by the risk stratification at diagnosis. Nevertheless, high risk patients could benefit from alloSCT, reaching an 2yOS of 42%.
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Sáez de la Fuente Aldama, Izaskun. „El hecho nacional en la desmembración de la URSS“. Estudios de Deusto 42, Nr. 1 (29.01.2015): 123. http://dx.doi.org/10.18543/ed-42(1)-1994pp123-172.
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Introducción. I. Marx y Engels. II. El postmarxismo y la cuestión nacional. III. Configuración de la Unión de Repúblicas Socialistas Soviéticas (URSS). IV. El Estado soviético. V. La cuestión nacional. VI. Posición de la URSS ante la ONU: La reformulación de Starushenko. VII. Política exterior. VIII. Gorbachov y su proyecto reformista. IX. El resurgimiento de los nacionalismos. X. El golpe de Estado. XI. El desmembramiento de la URSS.
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Kornyat, Iryna. „Digitization of Internal Control and Information Support for the Management of Transport Enterprises“. Central Ukrainian Scientific Bulletin. Economic Sciences, Nr. 9(42) (2023): 163–72. http://dx.doi.org/10.32515/2663-1636.2023.9(42).163-172.
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The effective functioning of the smart city creates prerequisites not only for automating the collection of accounting information about economic processes in transport, but also for comprehensive control over transport, passenger and cash flows. The use of modern computer and communication technologies in the smart city ensures the digitization of internal control for the purposes of effective management of transport enterprises, which determines the relevance of the topic of the article and makes it possible to form a goal. The main aim of the article is to improve the methodology of internal control and information support for the management of passenger carriers in the context of the use of modern computer and communication technologies. The article proves the importance of establishing the relationship between accounting, internal control and management of the transport enterprises activities. The methodology of internal control and information support of the management regarding the movement of vehicles in the city space, the performance of official duties by employees, the behavior of passengers and the circulation of funds has been improved. The procedure for digitalization of management decisions in the transport sector of the smart city based on accounting information, the reliability and relevance of which is confirmed by the internal control of passenger carriers, has been specified. The expediency of using a video surveillance system for the movement of transport, the performance of official duties by employees and the behavior of passengers in order to control and record the damage caused to the rolling stock of passenger carriers, other road users, passengers and employees, and the transport infrastructure of the smart city has been substantiated. The use of the developed information scheme of the control environment ensures the minimization of time and money spent by passengers, transport companies, municipal and state budgets for the provision of services for moving residents of the smart city.
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Clave, Emmanuel, Vanderson Rocha, Kimmo Talvensaari, Marc Busson, Corinne Douay, Marie-Lorraine Appert, Claire Rabian et al. „Prognostic value of pretransplantation host thymic function in HLA-identical sibling hematopoietic stem cell transplantation“. Blood 105, Nr. 6 (15.03.2005): 2608–13. http://dx.doi.org/10.1182/blood-2004-04-1667.
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Abstract Thymic function is critical for immune reconstitution after hematopoietic stem cell transplantation (HSCT). We evaluated recipient thymic function before HSCT by quantifying T-cell receptor excision circles (TRECs) in pretransplantation peripheral blood lymphocytes from 102 patients who received HSCs from an HLA-identical sibling for malignant (n = 87) or nonmalignant diseases (n = 15). Median TREC value before transplantation was 257 TRECs per 150 000 CD3+ cells (range, 0-42 746). We assessed 172 TRECs per 150 000 CD3+ cells as the most discriminating TREC value for survival in a first cohort of patients (n = 62). This cut-off was validated in a second independent prospective group of 40 patients. In the 102 patients, a TREC value greater than or equal to 172 was associated with a better survival (P < .000 01), a decreased incidence of grade II-IV acute graft-versus-host disease (GVHD; P = .017), chronic GVHD (P = .023), and bacterial (P = .003) and cytomegalovirus (CMV) infection (P = .024). In a multivariate analysis, low pretransplantation TREC values were associated with a higher incidence of CMV infection (hazard ratio [HR] = 2.0, P = .06) and severe bacterial infections (HR = 2.8, P = .036). Finally, high TREC values (HR = 6.6, P = .002) and ABO compatibility (HR = 2.7, P = .02) were associated with a better survival. Therefore, recipient host thymic function assessment could be helpful in predicting HSCT outcome and identifying patients who require a close immunologic monitoring.
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Kober, Daniel, Colin Kluender und Thomas Brett. „P4-172: BIOPHYSICAL INVESTIGATION OF THE TREM2 INTERACTIONS WITH APOE AND AMYLOID BETA1-42 REVEAL TWO DISTINCT BINDING SURFACES AND A POTENTIAL ROLE FOR STREM2 AS AN INHIBITOR OF AMYLOID BETA1-42 POLYMERIZATION“. Alzheimer's & Dementia 15 (Juli 2019): P1340. http://dx.doi.org/10.1016/j.jalz.2019.06.3834.
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Matia, Graciele De, Aline Ferreira, Jane Melissa Webler, Juliana Ollé Mendes da Silva und Leandro Rozin. „Adesão aos cinco momentos de higienização das mãos em unidades de terapia intensiva de um hospital pediátrico“. Espaço para a Saúde - Revista de Saúde Pública do Paraná 18, Nr. 2 (17.12.2017): 96. http://dx.doi.org/10.22421/1517-7130.2017v18n2p96.
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O objetivo do estudo foi avaliar a adesão dos profissionais de saúde nos cinco momentos da higienização das mãos nas Unidades de Terapia Intensiva de um hospital pediátrico por meio de informações obtidas no banco de dados da instituição. O método utilizado foi o exploratório, descritivo, de base documental e abordagem quantitativa, entre os profissionais que prestavam assistência aos pacientes. Foram incluídos os fisioterapeutas com maior adesão à Higienização das Mãos (HM), antes do contato com o paciente (100%). Os técnicos de enfermagem 138 de 312 (44,2%), médicos 55 de 172 (32%) e enfermeiros 42 de 135 (31,1%), foram os que menos realizaram a HM antes do contato com o paciente. Nota-se que a capacitação com a equipe multidisciplinar deve ser realizada continuamente com o intuito de conscientizar dos riscos e prevenir a infecção hospitalar que os pacientes estão expostos.
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Phillips, Susan, Timothy C. Granade, Chou-Pong Pau, Debra Candal, Dale J. Hu und Bharat S. Parekh. „Diagnosis of Human Immunodeficiency Virus Type 1 Infection with Different Subtypes Using Rapid Tests“. Clinical Diagnostic Laboratory Immunology 7, Nr. 4 (01.07.2000): 698–99. http://dx.doi.org/10.1128/cdli.7.4.698-699.2000.
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ABSTRACT We evaluated six rapid tests for their sensitivity and specificity in diagnosing human immunodeficiency virus type 1 (HIV-1) infection using 241 specimens (172 HIV-1 positive, 69 HIV-1 negative) representing different HIV-1 subtypes (A [n = 40], B [n = 47], C [n = 28], E [n = 42], and F [n = 7]). HIVCHEK, Multispot, RTD and SeroStrip were 100% sensitive and specific. Capillus failed to identify two of eight subtype C specimens (overall sensitivity of 98.85%), while the SUDS test (the only test approved by the Food and Drug Administration) gave false-positive results for 5 of 69 seronegative specimens (specificity of 93.24%). Our results suggest that although rapid tests perform well in general, it may be prudent to evaluate a rapid test for sensitivity and specificity in a local population prior to its widespread use.
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VILLAMARIN MENZA, SAMUEL. „PREVALENCIA DE SOBREPESO Y OBESIDAD EN NIÑAS Y NIÑOS ESCOLARES DE 11 A 15 AÑOS DEL MUNICIPIO DE GALAPA, ATLÁNTICO“. REVISTA EDUCACIÓN FÍSICA, DEPORTE Y SALUD 3, Nr. 5 (09.02.2022): 115–31. http://dx.doi.org/10.15648/redfids.5.2020.3169.
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El objetivo de esta investigación es conocer la prevalencia de sobrepeso y obesidad en una institución educativa del Municipio de Galapa, Atlántico. La metodología contempla un estudio de tipo descriptivo, de corte transversal y de enfoque mixto; se midieron 133 niñas y 172 niños para un total de 305 escolares, de 11 a 15 años, a quienes se les midió el peso corporal, la talla y se calculó en IMC. Como resultados de la investigación se halló que 23 mujeres y 9 hombres tienen sobrepeso y 6 mujeres y 4 hombres tienen obesidad, para un total de 42 sujetos, es decir el 10.49% de la muestra tiene sobrepeso y 3.28% de la muestra tiene obesidad. Esto puede calificarse como una prevalencia baja de sobrepeso y obesidad, comparada con los indicadores nacionales e internacionales que muestran una mayor magnitud del problema
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Sasmal, Prakash Kumar, Kallol Kumar Das Poddar, Tushar Subhadarshan Mishra und Pankaj Kumar. „Surgical Site Infections in Patients of Periampullary Carcinoma Undergoing Delayed Bile Duct Division (COMBILAST) in Whipple’s Procedure: A Prospective Cohort Study“. Pathogens 12, Nr. 3 (13.03.2023): 448. http://dx.doi.org/10.3390/pathogens12030448.
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Surgical site infections (SSIs) following a pancreaticoduodenectomy have been a significant cause of morbidity and even mortality. A modified sequence of the Whipple procedure, using the COMBILAST technique, may reduce SSIs and the patient’s hospital stay. This prospective cohort study included 42 patients undergoing Whipple’s pancreaticoduodenectomy for a periampullary malignancy. The modified sequence pancreaticoduodenectomy technique, COMBILAST, was used to estimate the incidence of SSI and explore other advantages. Of the 42 patients, seven (16.7%) developed superficial SSIs, and two patients (4.8%) had an additional deep SSI. Positive intraoperative bile culture had the strongest association with SSI (OR: 20.25, 95% CI: 2.12, 193.91). The mean operative duration was 391.28 ± 67.86 min, and the mean blood loss was 705 ± 172 mL. A total of fourteen (33.3%) patients had a Clavien–Dindo grade of III or higher. Three (7.1%) patients died of septicemia. The average length of a hospital stay was 13.00 ± 5.92 days. A modified sequence of the Whipple procedure, using the COMBILAST technique, seems promising in reducing SSIs and the patient’s hospital stay. As the approach is only a modification of the operative sequence, it does not compromise the oncological safety of the patient. Moreover, it has an added surgical advantage in reducing the chance of injury to the aberrant or accessory right hepatic artery.
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Faloon, Jordan, Karly Bishop, Wendy Craig und Julia Brock. „Characterizing the use of osteopathic manipulative medicine in the obstetric population by trimester and indications for use“. Journal of Osteopathic Medicine 121, Nr. 1 (01.01.2021): 85–96. http://dx.doi.org/10.1515/jom-2019-0204.
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Abstract Context Osteopathic manipulative medicine (OMM) has been shown to successfully alleviate some pregnancy-related pain. However, most of the published data focuses on the third trimester and postpartum period or musculoskeletal indications. Objective To explore OMM use among obstetrical providers and determine the frequency of use by trimester and by clinical indications across multiple types of women’s healthcare practices in Southern and Central Maine. Methods An anonymous, 43-item survey, presented in English, was emailed to 172 eligible providers (physicians, nurse practitioners, and certified nurse midwives with obstetrics privileges at one of two main delivery centers in southern and central Maine) via an encrypted database system in January 2018. Follow-up email reminders were sent weekly for three weeks. Questions addressed use of OMM for specific indications, knowledge of OMM, and perceived barriers use of OMM. Results The survey response rate was 73 of 172 (42%); 95% of respondents were physicians (n=69). Due to the low response rate of non-physicians, only data from physicians was included in the study. Data were summarized descriptively as frequencies (n [%]). The highest rates of OMM utilization were during the third trimester (35 [51.5%]) and postpartum (41 [60.3%]) periods, while the lowest rates of utilization were in the intrapartum (eight [11.9%]) and first trimester periods (26 [38.3%]). Osteopathic physicians (n=19) used OMM more frequently in the first, second, and third trimesters, as well as the intrapartum period (10 [52.6%]; 11 [57.9%]; 14 [73.7%]; and six [31.6%], respectively) compared with their allopathic physician (n=50) counterparts (nine [8%]; 15 [30%]; 21 [42%]; and two [4%], respectively). While osteopathic physicians reported higher frequencies of OMM use and referral for non-musculoskeletal indications such as constipation, edema, and nasal congestion (13 [68.4%]; 11 [57.9%]; 10 [52.6%], respectively), musculoskeletal complaints were the most frequently cited indication for OMM use among both osteopathic and allopathic physicians (low back, 67 [97.1%]; pelvis, 65 [94.2%]; coccyx, 50 [72.5%]; and head, 49 [71%]). Conclusion These results suggest that more education is needed about OMM use in the obstetric population, particularly during early trimesters and the intrapartum period, as well as for visceral and lymphatic complaints of pregnancy.
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Combs, Stephanie E., Christoph Thilmann, Lutz Edler, Jürgen Debus und Daniela Schulz-Ertner. „Efficacy of Fractionated Stereotactic Reirradiation in Recurrent Gliomas: Long-Term Results in 172 Patients Treated in a Single Institution“. Journal of Clinical Oncology 23, Nr. 34 (01.12.2005): 8863–69. http://dx.doi.org/10.1200/jco.2005.03.4157.
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Purpose To evaluate the efficacy of fractionated stereotactic radiotherapy (FSRT) performed as reirradiation in 172 patients with recurrent low- and high-grade gliomas. Patients and Methods Between 1990 and 2004, 172 patients with recurrent gliomas were treated with FSRT as reirradiation in a single institution. Seventy-one patients suffered from WHO grade 2 gliomas. WHO grade 3 gliomas were diagnosed in 42 patients, and 59 patients were diagnosed with glioblastoma multiforme (GBM). The median time between primary radiotherapy and reirradiation was 10 months for GBM, 32 months for WHO grade 3 tumors, and 48 months for grade 2 astrocytomas. FSRT was performed with a median dose of 36 Gy in a median fractionation of 5 × 2 Gy/wk. Results Median overall survival after primary diagnosis was 21 months for patients with GBM, 50 months for patients with WHO grade 3 gliomas, and 111 months for patients with WHO grade 2 gliomas. Histologic grading was the strongest predictor for overall survival, together with the extent of neurosurgical resection and age at primary diagnosis. Median survival after reirradiation was 8 months for patients with GBM, 16 months for patients with grade 3 tumors, and 22 months for patients with low-grade gliomas. Only time to progression and histology were significant in influencing survival after reirradiation. Progression-free survival after FSRT was 5 months for GBM, 8 months for WHO grade 3 tumors, and 12 months for low-grade gliomas. Conclusion FSRT is well tolerated and may be effective in patients with recurrent gliomas. Prospective studies are warranted for further evaluation.
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Lee, John Y., Ryan A. Gallo und Chrisfouad R. Alabiad. „Evaluating the Effectiveness of Small-Group Training in Teaching Medical Students Integral Clinical Eye Examination Skills“. Journal of Academic Ophthalmology 12, Nr. 01 (Januar 2020): e79-e86. http://dx.doi.org/10.1055/s-0040-1712175.
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Abstract Objective The aim of this study is to evaluate the effectiveness of an interactive, small-group ophthalmology clinical training session by assessing medical students' self-confidence with eye examination skills and long-term retention of direct ophthalmoscopy skills. Methods The second-year medical students participated in a one-time small-group clinical training session that taught essential components of the eye examination. Students reported their confidence with each component in pre- and postsession surveys. Eight months later, direct ophthalmoscopy skills were reassessed by having students visualize the optic nerves of standardized patients and identify the matching optic nerve photograph in a multiple-choice quiz. Results Among 197 second-year medical students who participated in the training session, 172 students completed the presession survey (87.3% response rate) and 108 students completed the postsession survey (54.8% response rate). Following the training session, students reported increased self-confidence (p < 0.01) overall. A total of 107 (107/108; 99.1%) students reported that they visualized the optic nerve head, and 80 out of 85 (94.1%) students stated that they preferred the PanOptic ophthalmoscope over the traditional direct ophthalmoscope. Students reported greater self-confidence using the PanOptic ophthalmoscope (p < 0.01). In the 8-month follow-up assessment, 42 medical students (42/197; 21.3%) completed the exercise. A total of 41 (41/42; 97.6%) students stated that they saw the optic nerve with the PanOptic ophthalmoscope; 24 (24/42; 57.1%) students identified the correct optic nerve image using the PanOptic ophthalmoscope on a standardized patient; 14 (14/42; 33.3%) students stated that they saw the optic nerve with the traditional direct ophthalmoscope; and 4 (4/42; 9.1%) students from the same cohort identified the correct optic nerve image with the traditional direct ophthalmoscope on a standardized patient. Conclusion Our comprehensive, one-time eye examination skills training session seeks to prepare students to incorporate these skills in future patient care. Students' overall confidence improved in each aspect of the eye examination that was covered. A follow-up assessment on students' direct ophthalmoscopy skills suggests that the PanOptic ophthalmoscope allows for superior skills retention as compared with the traditional direct ophthalmoscope. We believe that the PanOptic ophthalmoscope should be further integrated into medical education and clinical practice.
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Sasaki, Hidefumi, Meiru Dai, Daniel Auclair, Masahiro Kaji, Ichiro Fukai, Masanobu Kiriyama, Yosuke Yamakawa, Yoshitaka Fujii und Lan Bo Chen. „Corrigendum to “Serum level of the periostin, a homologue of an insect cell adhesion molecule, in thymoma patients” [Cancer Letters 172 (2001) 37–42]“. Cancer Letters 202, Nr. 1 (Dezember 2003): 117. http://dx.doi.org/10.1016/s0304-3835(03)00217-9.
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Bichuetti, Denis Bernardi, Alessandra Billi Falcão, Fernanda de Castro Boulos, Marilia Mamprim de Morais, Claudia Beatriz de Campos Lotti, Manuela de Oliveira Fragomeni, Maria Fernanda Campos, Nilton Amorim de Souza und Enedina Maria Lobato Oliveira. „The profile of patients followed at the Neuroimmunology Clinic at UNIFESP: 20 years analysis“. Arquivos de Neuro-Psiquiatria 73, Nr. 4 (April 2015): 304–8. http://dx.doi.org/10.1590/0004-282x20150004.
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Objective To describe the clinical activities at the Neuroimmunology Clinic of the Universidade Federal de São Paulo (UNIFESP) from 1994 to 2013. Method The final diagnosis of all patients that attended the center was reviewed and established upon specific guidelines for each disease. The number of total appointments and extra clinical activities (reports and prescriptions) were also analyzed, as are part of routine activities. Results 1,599 patients attended the Clinic from 1994 to 2013: 816 with multiple sclerosis (MS), 172 with clinical isolated syndromes, 178 with neuromyelitis optica (NMO), 216 with other demyelinating disease, 20 with metabolic disorder, 42 with a vascular disease and 155 with other or undetermined diagnosis. A mean 219 outpatient visits and 65 extra clinical activities were performed monthly. Conclusion We identified that 15% of patients seen have NMO. As patients with NMO have a more severe disease than MS, this data may be important for planning local health care policies.
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Laçin, Nihat, Emre Aytuğar und İlknur Veli. „Cone-beam computed tomography evaluation of bifid mandibular canal in a Turkish population“. International Dental Research 8, Nr. 2 (27.08.2018): 78–83. http://dx.doi.org/10.5577/intdentres.2018.vol8.no2.5.
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Aim: The aim of the study was to examine the prevalence of bifid mandibular canals (BMC) in a Turkish population, using cone-beam computed tomography (CBCT).
Methodology: The CBCT images of 350 untreated patients (178 male, 172 female ranging in age between 18 and 65,) were included in this study. The presence or absence of BMC was determined in axial, sagittal, and coronal planes by considering gender and side. For statistical evaluation, a chi‑square test was used to determine any differences in the prevalence of BMC with significance set at 5%.
Results: BMCs were observed in 129 out of 700 sides (18.42%) and 97 out of 350 patients (27.71%), of which, 55 were in males and 42 in females. Regardless of gender, the right side was more frequently affected (73%). Male patients showed higher prevalence (15.71%) than the female patients (12%).
Conclusion: BMC was observed in 27.71% of examined Turkish subjects and detected more frequently in males and on the right side.
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Lenferink, Lonneke I. M., Angela Nickerson, Jos de Keijser, Geert E. Smid und Paul A. Boelen. „Reciprocal Associations Among Symptom Levels of Disturbed Grief, Posttraumatic Stress, and Depression Following Traumatic Loss: A Four-Wave Cross-Lagged Study“. Clinical Psychological Science 7, Nr. 6 (23.09.2019): 1330–39. http://dx.doi.org/10.1177/2167702619858288.
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Disturbed grief, operationalized as persistent complex bereavement disorder (PCBD), correlates with yet differs from posttraumatic stress disorder (PTSD) and depression symptoms. However, knowledge about temporal associations among these symptoms is limited. We aimed to enhance our understanding of the etiology of loss-related distress by examining temporal associations among PCBD, PTSD, and depression symptom levels. Dutch people ( N = 172) who lost significant other(s) in a plane disaster completed questionnaires for PCBD, PTSD, and depression 11, 22, 31, and 42 months after the disaster. Cross-lagged analyses revealed that changes in PCBD symptom levels have a greater impact on changes in symptom levels of PTSD and depression than vice versa. Our findings contradict the notion that PTSD and depression symptoms should be addressed before grief in treatment. Pending replication of our findings in clinical samples, we tentatively conclude that screening and treatment of grief symptoms has potential value in preventing long-lasting distress.
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Sixt, Sebastian, Aljoscha Rastan, Dierk Scheinert, Hans Krankenberg, Hermann Steinkamp, Andrej Schmidt, Horst Sievert et al. „The 1-Year Clinical Impact of Rotational Aspiration Atherectomy of Infrainguinal Lesions“. Angiology 62, Nr. 8 (08.05.2011): 645–56. http://dx.doi.org/10.1177/0003319711403300.
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The present study was carried out to provide information about outcome of the Jetstream atherectomy device for treatment of infrainguinal arteries. From February 2006 to February 2007, 172 patients with Rutherford class 1 to 5 lower limb ischemia were enrolled at 9 study sites. The endpoints were evaluation of quality of life according to the walking impairment questionnaire (WIQ) besides technical parameters. In the total study cohort, the WIQ scale maintained improved up to 12-month follow-up. Furthermore, target lesion revascularization rate was 26% (42/162), ankle-brachial index (ABI) increased from 0.59 ± 0.21 at baseline to 0.82 ± 0.27 ( P < 0.05), and mean Rutherford class dropped from 3.0 ± 0.9 at baseline to 1.5 ± 1.3 at 1 year ( P < .05). The results of this prospective, multicenter, clinical study demonstrate that the Jetstream atherectomy device is a potential treatment alternative for the endovascular management to improve clinical outcome in patients with peripheral arterial occlusive disease.
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Elstrom, Rebecca, Liang Guan, Gary Baker, Khozaim Nakhoda, Jo-Anne Vergilio, Hongming Zhuang, Stephanie Pitsilos et al. „Utility of FDG-PET scanning in lymphoma by WHO classification“. Blood 101, Nr. 10 (15.05.2003): 3875–76. http://dx.doi.org/10.1182/blood-2002-09-2778.
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Abstract We retrospectively evaluated 18fluoro-2-deoxyglucose positron emission tomography (FDG-PET) scans in 172 patients with lymphoma and correlated results with pathologic diagnosis using the World Health Organization (WHO) classification system. In total, FDG-PET detected disease in at least one site in 161 patients (94%) and failed to detect disease in 11 patients (6%). The most frequent lymphoma diagnoses were diffuse large B-cell lymphoma (LBCL; n = 51), Hodgkin lymphoma (HL; n = 47), follicular lymphoma (FL; n = 42), marginal zone lymphoma (MZL; n = 12), mantle cell lymphoma (MCL; n = 7), and peripheral T-cell lymphoma (PTCL; n = 5). FDG-PET detected disease in 100% of patients with LBCL and MCL and in 98% of patients with HL and FL. In contrast, FDG-PET detected disease in only 67% of MZL and 40% of PTCL. Comparison with bone marrow biopsies showed that FDG-PET was not reliable for detection of bone marrow involvement in any lymphoma subtype.
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Suvedi, B. K. „A Report On Knowledge, Attitude, Use-Pattern And Availability Of Jeevan Jal(Pre-Packaged Oral Rehydration Slts) In Baitadi“. Journal of Nepal Medical Association 26, Nr. 1 (01.01.2003): 19–28. http://dx.doi.org/10.31729/jnma.1579.
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A Study regarding the knowledge, altitude, use pattern and availabity of Jeevan Jal JJ was undertaken in the remote hilly district of Baitadi of Far Western Development Region of Nepal. The study shows that the females are less aware(38.7% about Jeevan Jal than the males (76%). 57.3% of the total respondents had knowledge about Jeevan Jal, 42% know the use of it and 28.3% consider it should be given in diarrhoes accordingly as recommended. 64.5% of those, who have seen JJ (116/172) had prepared its solution, but only 27.6% (32/116) can make it correctly, (and the males leading again-17.3% versus 4% females, that is only 10.6% of the total,) and 62.9% know that it must be used within24 hours of preparation of the solution. 98% of the respondents found it is not available in the village panchayat office or worker (31.2%) and/or centrally located home in the village(29.5%).
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Rosen, Michael R., Harrison Lakehomer, Connor S. Kasik und Kyle Stephenson. „Suture and anchors may be retained during treatment of deep infection after rotator cuff repair: a systematic review“. Journal of ISAKOS: Joint Disorders & Orthopaedic Sports Medicine 4, Nr. 2 (13.02.2019): 108–12. http://dx.doi.org/10.1136/jisakos-2018-000241.
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ImportanceRotator cuff repairs (RCRs) are one of the most common orthopaedic surgeries performed, and infection is a rare but serious complication. It is important to know the ideal management of infection after RCR.ObjectiveTo systematically review the literature regarding deep infection following RCR to characterise the success and failure rates of irrigation and debridement (I & D), with particular attention focused on potential predictors of failure, retention of suture anchor hardware and the necessity for serial I & Ds.Evidence reviewFour databases (Embase, PubMed, Google Scholar and EBSCOHost) were screened for clinical studies involving the treatment of infection after RCR. A full-text review of eligible studies was conducted. Inclusion and exclusion criteria were applied to the searched studies. Data from the selected studies were combined for comparative analysis to elucidate factors associated with the success of I & D.FindingsWe identified 11 eligible studies involving 172 patients. These studies described the number of I & D procedures necessary for successful treatment of infection after RCR. The mean number of I & Ds while retaining suture anchors and suture material was 2.3, compared with 2.2 I & Ds when removing all hardware. Propionibacterium acnes was the most common organism cultured, seen in 75 of 172 (43.6%) patients. Staphylococcus aureus and S. epidermidis accounted for 40 (23.3%) and 42 (24.4%) cases, respectively.Conclusions and relevanceIn managing infection following RCR, the current literature supports retaining suture anchors and suture material when the prior repair is found intact at the initial I & D. Further studies are necessary to strengthen the evidence for retaining hardware and ensuring there is not a statistically significant difference between the number of I & Ds needed to eradicate infection with the routine retention versus removal of suture anchors in this setting.Level of evidenceLevel IV, systematic review of Level III and IV studies.
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Bolotov, V. V., und V. A. Sachkov. „The influence of oxygen as impurity substitution defects on the electronic structure of binary graphene“. Omsk Scientific Bulletin, Nr. 172 (2020): 42–46. http://dx.doi.org/10.25206/1813-8225-2020-172-42-46.
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Averchev, O., O. Shablia und N. Avercheva. „FEATURES OF PRODUCTION AND MARKETING OF MELON IN THE WORLD AND UKRAINE“. Scientific papers OF DMYTRO MOTORNYI TAVRIA STATE AGROTECHNOLOGICAL UNIVERSITY (ECONOMIC SCIENCES) 42 (2020): 164–72. http://dx.doi.org/10.31388/2519-884x-2020-42-164-172.
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Pinigin, V. G. „Media Competencies of Secondary School Teachers and Their Areas of Application“. Review of Omsk State Pedagogical University. Humanitarian research, Nr. 42 (2024): 169–72. http://dx.doi.org/10.36809/2309-9380-2024-42-169-172.
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The article discusses the issue of media competence of modern teachers, which is a dynamically developing set of skills in the use of interactive technologies, means of working with information, methods of transmitting educational material and testing its mastery. The media competencies of teachers are directly related to the field of audiovisual communication, which includes SMM channels, social networks, and special educational electronic platforms. The article also raises the question of the areas of application of pedagogical media competencies and their effectiveness of use.
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Edgington, Steve, Alan G. Buddie, Lukasz Tymo, David J. Hunt, Khuong B. Nguyen, Andrés I. France, Loreto M. Merino und Dave Moore. „Steinernema australe n. sp. (Panagrolaimomorpha: Steinernematidae), a new entomopathogenic nematode from Isla Magdalena, Chile“. Nematology 11, Nr. 5 (2009): 699–717. http://dx.doi.org/10.1163/156854108x399326.
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Abstract A new species of entomopathogenic nematode, Steinernema australe n. sp., was isolated from a soil sample taken close to the beach on Isla Magdalena, an island in the Pacific Ocean, 2 km from mainland Chile. Morphologically the new species belongs to the glaseri-group and is characterised by morphometrics of the infective juvenile which has a very long body of 1316 (1162-1484) μm, excretory pore located far posterior to the anterior extremity (110 (95-125) μm), exceptionally long tail of 103 (92-114) μm, H% = 51 (42-61), E% = 107 (94-122) and a ratio = 35 (31-38). The first generation male has 72 (55-78) μm long spicules, a 45 (36-51) μm long gubernaculum and SW% = 172 (118-196). The first generation female can be recognised by well developed double epiptygmata, the lack of a prominent postanal swelling, a mucron on the tail tip and (in 60% of individuals) one to two subsidiary mucrons. Sequences of the ITS and D2D3 regions of the ribosomal DNA confirm that S. australe n. sp. is a valid species.
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Carder, Paula, Lindsey Smith, Taylor Bucy, Jaclyn Winfree, Wenhan Zhang und Kali Thomas. „Variation in Assisted Living Regulations Within and Across States“. Innovation in Aging 4, Supplement_1 (01.12.2020): 715–16. http://dx.doi.org/10.1093/geroni/igaa057.2523.
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Abstract Assisted living (AL) regulations have been long recognized as being highly variable across states. A new approach developed by our team, Health Services Regulatory Analysis, allows for a more granular identification of within-state variation in AL regulation. We identified 172 licensing classifications from the 50 states and DC representing 58 primary license types, 48 sub-types, and 66 designations that can modify a primary or sub-license. Over two-thirds (72%) of dementia-specific classifications require that all staff receive initial dementia training, compared to only one-third (33%) of general AL classifications. This trend is similarly reflected in cognitive-screening requirements, present in 67% of dementia-specific classifications and 42% of general AL classifications. Regulatory theory describes how licensing agencies respond to various forces and values. Within-state AL regulatory variation reflects a combination of oversight mandates, population-specific needs (e.g., people with dementia), historic policies, and provider influence, with implications for consumers, policy-makers and researchers. Part of a symposium sponsored by Assisted Living Interest Group.
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Duan, Hongfei, Guan Liu, Xiaobo Wang, Yuhong Fu, Qian Liang, Yuanyuan Shang, Naihui Chu und Hairong Huang. „Evaluation of the Ribosomal Protein S1 Gene (rpsA) as a Novel Biomarker forMycobacteriumSpecies Identification“. BioMed Research International 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/271728.
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Objectives. To evaluate the resolution and reliability of therpsAgene, encoding ribosomal protein S1, as a novel biomarker for mycobacteria species identification.Methods. A segment of therpsAgene (565 bp) was amplified by PCR from 42 mycobacterial reference strains, 172 nontuberculosis mycobacteria clinical isolates, and 16M. tuberculosiscomplex clinical isolates. The PCR products were sequenced and aligned by using the multiple alignment algorithm in the MegAlign package (DNASTAR) and the MEGA program. A phylogenetic tree was constructed by the neighbor-joining method.Results. Comparative sequence analysis of therpsAgene provided the basis for species differentiation within the genusMycobacterium. Slow- and rapid-growing groups of mycobacteria were clearly separated, and each mycobacterial species was differentiated as a distinct entity in the phylogenetic tree. The sequences discrepancy was obvious betweenM. kansasiiandM. gastri, M. chelonaeandM. abscessus, M. aviumandM. intracellulare, andM. szulgaiandM. malmoense, which cannot be achieved by 16S ribosomal DNA (rDNA) homologue genes comparison. 183 of the 188 (97.3%) clinical isolates, consisting of 8 mycobacterial species, were identified correctly byrpsAgene blast.Conclusions. Our study indicates thatrpsAsequencing can be used effectively for mycobacteria species identification as a supplement to 16S rDNA sequence analysis.
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Mielcarek, Marco, Barry Storer, Paul J. Martin, Stephen J. Forman, Robert S. Negrin, Mary E. Flowers, Yoshihiro Inamoto et al. „Long-term outcomes after transplantation of HLA-identical related G-CSF–mobilized peripheral blood mononuclear cells versus bone marrow“. Blood 119, Nr. 11 (15.03.2012): 2675–78. http://dx.doi.org/10.1182/blood-2011-12-396275.
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Abstract Between 1996 and 1999, 172 patients (median age, 42 years) with hematologic malignancies were randomly assigned to receive either HLA-identical related bone marrow or G-CSF–mobilized peripheral blood mononuclear cells (G-PBMCs) after myeloablative conditioning. Early results showed that transplantation of G-PBMCs, compared with marrow, was associated with significantly superior 2-year disease-free survival (DFS) and overall survival. Ten-year follow-up showed a sustained DFS benefit associated with G-PBMCs (mortality or relapse hazard ratio, 0.64; 95% confidence interval, 0.4-1.0; P = .03), although the likelihood of overall survival was not significantly different between the 2 groups (mortality hazard ratio, 0.75; 95% confidence interval, 0.5-1.2; P = .20). The 10-year cumulative incidence of chronic GVHD and the duration of systemic immunosuppression were similar in the 2 groups. In summary, transplantation of HLA-identical related G-PBMCs, compared with marrow, was associated with superior short-term and long-term DFS, and there was no evidence that this benefit was outweighed by GVHD-related late mortality.
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Maitra, Tapash Kumar, Mahmud Ekram Ullah, Faruquzzaman und Samiran Kumar Mondol. „Operative and Postoperative Complications of Laparoscopic Cholecystectomy: Experience from a Tertiary Care Hospital of Bangladesh“. Bangladesh Critical Care Journal 5, Nr. 1 (11.05.2017): 11–16. http://dx.doi.org/10.3329/bccj.v5i1.32536.
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Background: The technique of laparoscopic surgery has rapidly become popular because of its several advantages over conventional open surgery. The reduction of postoperative pain provided positive human impact, and the reduction of length of hospital stay as well as the earlier return to work generated a positive socioeconomic impact. However, in spite of being a minimally invasive technique, this procedure has different peroperative and postoperative complications which cannot be disregarded.Objective: To evaluate the complications of laparoscopic cholecystectomy in symptomatic and asymptomatic cholelithiasis and other benign gall bladder diseases.Methodology: 172 patients who underwent laparoscopic cholecystectomy were included in this prospective study on the basis of non-randomized convenient sampling from a period of September 30, 2014 to September 30, 2016 in BIRDEM General Hospital, Dhaka, Bangladesh. Data of the patients regarding outcomes and complications were analyzed.Result: Results of this study suggests that 35.5% cases were male and 64.5% patients were female. In male group, most of the patients (18.0%) were in 41-50 years of age group followed by 9.9% in 51-60 years age group, whereas among the female patients these were 33.1% and 15.7% respectively. Mean±SD of age were46±1.7 and 42±1.3 years in case of male and female patients respectively.In 119 (69.2%) out of total 172 cases, laparoscopic cholecystectomy was done for chronic cholecystitis and in 18.6% (32 out of total 172) cases, it was performed for acute cholecystitis. Intra-operative bile leak(11.0%) was found to be the most frequent complications during laparoscopic cholecystectomy. The incidence rates of perforation of gall bladder, stone spillage were 9.3% and 5.2% respectively. Trocar site, vascular, and hepatic bed hemorrhages were 7.0%, 4.7% and 4.0% respectively. Open conversion was done in 17 cases (9.9%). Port site infection and post cholecystectomy syndrome developed in 5.2% and 4.7% cases respectively. The overall mortality was approximately 1.1%. Serious complications likebowel injury and bile duct injury were recorded in 0.6% and 1.2% cases respectively.The results of this study suggest that gender, age, co-morbidities, previous abdominal surgery, acute cholecystitis, obesity, thickened gall bladder wall on ultrasound, history of preoperative ERCPare probablyimportant and clinically significant relevant factors for open conversion of laparoscopic cholecystectomy.Conclusion: In our study, complications of laparoscopic cholecystectomy were similar to those of different centres in western countries. We found laparoscopic cholecystectomy as a safe and effective procedure in almost all patients with cholelithiasis. Proper preoperative work up, awareness of possible complications and adequate training on laparoscopic technique make this operation a safe procedure with favorable result and lesser complications.Bangladesh Crit Care J March 2017; 5(1): 11-16
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Helissey, Carole, Sophie Cavallero, Nathalie Guitard, Hélène Thery, Charles Parnot, Antoine Schernberg, Stanislas Mondot et al. „Urinary proteome as a prognostic factor in the deterioration of the quality of life of patients with localized prostate cancer during radiotherapy: Radiotoxicity Bladder Biomarkers (RABBIO) prospective trial.“ Journal of Clinical Oncology 41, Nr. 6_suppl (20.02.2023): 344. http://dx.doi.org/10.1200/jco.2023.41.6_suppl.344.
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344 Background: Despite improvements in radiation techniques, pelvic radiotherapy is responsible for acute and delayed bladder adverse events, defined as radiation cystitis (CysR). About 50% of irradiated patients present acute symptoms and experience a significant decrease in their quality of life (QOL). The pathophysiology of CysR is not well understood, which limits our ability to study this process and develop treatments. The RABBIO study evaluates the correlation of urinary biomarkers with the intensity of acute CysR and the QOL of patients, assessed with the digital telemonitoring platform Cureety. Methods: Patients with intermediate-risk localized prostate cancer eligible for localized radiotherapy were included. Urinary biomarkers were analyzed before the start of radiotherapy, and at weeks (W) 4, 12 and 48 of irradiation. Between sample collection visits, patients completed various questionnaires related to radiation cystitis symptoms and QOL using a digital remote monitoring platform. Upon receipt of the questionnaires, an algorithm processed the information and classify patients according to the severity of symptoms and adverse events reported according to CTCAE. We also collected FACT-P questionnaires at baseline, W4 and W12. We correlated the levels of urinary biomarkers with the severity of acute CysR symptoms and patient-reported QOL. Results: The study started in March 2022, with 15 patients included to date. The median age was 76 (range 65-99). 80% (15/17) presented a localized prostate cancer de novo and 20% presented a biochemical recurrence. The compliance was 100% at baseline, 93% at W4 and 100% at W12. We collected a total of 172 AE questionnaires over the duration of the study so far, of which 61.0% (105/172) indicated a correct health status and 31.4% (54/172) a compromised status. The mean (range) FACT-P score at baseline for all patients was 33.9 (24 – 40), which changed to 29.8 (20 – 35) at W4, and 38.7 (37 – 42) at W12. Elevated SHBG (p=0.019, r=-0.93) and decreased IL8 (p=0.034, r=0.91) at baseline correlated with worse FACT-P score at W4. Conclusions: This prospective study is the first to explore the overexpression of inflammatory proteins in fluid biopsies from patients with symptoms of acute CysR. Our first results revealed that an elevated SHBG and a decreased IL8 in urine at baseline were a prognostic factor in the deterioration of QOL for localized prostate cancer patients during radiotherapy. The results of this study will allow us to develop strategies to limit radiation damage to the bladder and improve the QOL of patients. Clinical trial information: NCT05246774 .
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Tomasevic, Zoran, Zorica Tomasevic, Ivana Minic und Daniela Kolarevic. „Characteristics of HER2 3+ metastatic breast cancer patients with long-term benefit of trastuzumab.“ Journal of Clinical Oncology 35, Nr. 15_suppl (20.05.2017): e12523-e12523. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e12523.
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e12523 Background: Because there is no cumulative dose, trastuzumab could be given until disease progression. However, characteristics of patients with long term benefit of trastuzumab treatment are seldom reported. Methods: Trastuzumab become available for HER2 3+ MBC at November 2005 at the Institute for Oncology and Radiology of Serbia. Since then, we have registered 42 patients with HER2 3+ MBC and/or inoperable loco-regional recurrent BC treated with first line trastuzumab for at least 24 months (range 24-123+). Results: Median age was 53 years (range 35-76). 30/42 patients (71%) had ER/PR positive BC. MBC was initial presentation in 14 patients (33%), and as relapse in 28 (67%) patients. Only 7/28 (25%) patients received neoadjuvant/adjuvant trastuzumab, therefore majority have been trastuzumab naive (83.3%). Metastases were present in the liver (9), lungs (9), bones (16), soft tissue (6), CNS (1), while 20 (48%) patients had multiple metastatic sites. After antracyclines based chemotherapy, patients have been treated with first line weekly taxane concurrently with three weekly trastuzumab. After taxanes (up to 24 doses), trastuzumab was continued +/-hormonal therapy. Objective response was achieved in 29 (69%) patients with 17 patients (40%) achieving complete response. Median duration of response was 32+ months; 11 patients are still in remission 5 years after trastuzumab initiation. The longest complete remission duration is 123+ months, in patient with initially inoperable BC and solitary cerebellar metastasis. During observational period 10 patients stopped trastuzumab predominantly because of disease progression (8/42 19%) and 2 (4.8%) because of decreased ejection fraction (EF≤ 50%) that occurred as a rather late effect, after 34 and 49 months of continuous trastuzumab treatment. Three patients are lost from follow-up (7%); 39 (93%) patients included in this analysis are alive, still receiving trastuzumab for median 37 cycles (range 29-172+). Conclusions: A subgroup of patient with HER2 3+ MBC has a long-term benefit of trastuzumab treatment. In this analysis majority (71%) had also ER/PR positive MBC and majority have not been treated with neoadjuvant/adjuvant trastuzumab (83.3%).
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Davis, Jennifer C., Chun Liang Hsu, Cindy Barha, Deborah A. Jehu, Patrick Chan, Cheyenne Ghag, Patrizio Jacova et al. „Comparing the cost-effectiveness of the Otago Exercise Programme among older women and men: A secondary analysis of a randomized controlled trial“. PLOS ONE 17, Nr. 4 (20.04.2022): e0267247. http://dx.doi.org/10.1371/journal.pone.0267247.
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Objective Using stratified analyses, we examined the cost-effectiveness of the Otago Exercise Programme (OEP), from a health care system perspective, among older women and men who have previously fallen. Methods This study was a secondary stratified analysis (by women and men), of a 12-month prospective economic evaluation of a randomized clinical trial (OEP compared with usual care). Three hundred and forty four community-dwelling older adults (≥70; 172 OEP (110 women; 62 men), 172 usual care (119 women; 53 men)) who sustained a fall in the past 12 months and received a baseline assessment at the Vancouver Falls Prevention Clinic, Canada were included. A gender by OEP/usual care interaction was examined for the falls incidence rate ratio (IRR). Outcome measures stratified by gender included: falls IRR, incremental cost-per fall prevented (ICER), incremental cost per quality adjusted life year (QALY, ICUR) gained, and mean total health care resource utilization costs. Results Men were frailer than women at baseline. Men incurred higher mean total healthcare costs $6794 (SD: $11906)). There was no significant gender by OEP/usual care interaction on falls IRR. The efficacy of the OEP did not vary by gender. The adjusted IRR for the OEP group demonstrated a 39% (IRR: 0.61, CI: 0.40–0.93) significant reduction in falls among men but not women (32% reduction (IRR: 0.69, CI: 0.47–1.02)). The ICER showed the OEP was effective in preventing falls and less costly for men, while it was costlier for women by $42. The ICUR showed the OEP did not impact quality of life. Conclusion Future studies should explore gender factors (i.e., health seeking behaviours, gender related frailty) that may explain observed variation in the cost-effectiveness of the OEP as a secondary falls prevention strategy. Trial registrations ClinicalTrials.gov Protocol Registration System Identifier: NCT01029171; URL: https://clinicaltrials.gov/ct2/show/NCT01029171 Identifier: NCT00323596; URL: https://clinicaltrials.gov/ct2/show/NCT00323596
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Jackson, M., D. Mattair, H. Lin, A. M. Gutierrez-Barrera, N. Elsayegh, J. K. Litton, G. N. Hortobagyi und B. Arun. „Identifying genomic rearrangements in BRCA1 and BRCA2 in high-risk individuals for hereditary breast and ovarian cancer.“ Journal of Clinical Oncology 29, Nr. 27_suppl (20.09.2011): 163. http://dx.doi.org/10.1200/jco.2011.29.27_suppl.163.
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163 Background: Germline mutations in the BRCA1 and BRCA2 genes are responsible for the majority of hereditary breast and ovarian cancer (HBOC). Comprehensive gene sequencing detects ~87% of BRCA mutations, and large genomic rearrangement testing (BART) accounts for ~3%. Criteria have been established to capture individuals who most likely have a BART mutation, however, recent data shows that some individuals have BART mutations and do not meet the criteria. We conducted a single-institution study to evaluate the sufficiency of BART criteria to determine if new criteria are warranted. Methods: During 2006-2008, 172 individuals underwent BRCA sequencing and BART at M. D. Anderson Cancer Center. A retrospective, IRB-approved chart review of a prospectively maintained database was conducted to determine BART criteria eligibility, personal/family history of breast and ovarian cancer and tumor characteristics. Univariate and multivariate analysis was performed to test the significance of each variable in relation to BRCA1/BRCA2 positivity. Results: Of 172 individuals, 12/34 (35%) had BRCA1 BART mutations, and 7/11 (64%) had BRCA2 BART mutations. Of the 19 individuals who tested positive for BART mutations, only 8 (42%) met BART criteria and 11 (58%) did not and proceeded with BART for various reasons (family history, insurance covered, and patient request). Individuals who were BRCA1 positive (sequencing or BART) were more likely to have ER/PR negative breast cancer (p<0.0001) and a personal (p=0.0215)/family history of ovarian cancer (p=0.0001) compared to non-carriers and individuals who had no family history Individuals who were BRCA1 sequencing positive were more likely to meet BART criteria than BRCA1 BART positive (p=0.0151) individuals. Conclusions: Given that no significant differences in family history/tumor characteristics between individuals who have sequencing and BART mutations were identified, and a majority of individuals who were BART positive do not meet BART criteria, it appears that these criteria may be insufficient. BART testing should be considered for all individuals who undergo BRCA sequencing; however, large scale collaboration studies should be conducted.
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Gumz, Jonathan, und Diego Castro Fettermann. „Benefícios e barreiras para aceitação de medidores inteligentes residenciais“. Revista Produção Online 21, Nr. 1 (15.03.2021): 131–56. http://dx.doi.org/10.14488/1676-1901.v21i1.4179.
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Programas de implantação de medidores inteligentes nas residências são fundamentais para se atingirem as metas de modernização da rede elétrica e uso racional das fontes de energia. Porém, além da implantação dos aparelhos nas residências é necessária a aceitação dos consumidores, que possuem papel fundamental na redução do uso de energia elétrica. O objetivo deste estudo é investigar na literatura quais fatores influenciam positivamente (benefícios) e negativamente (barreiras) para a aceitação. Para isso, foi realizada uma revisão sistemática da literatura usando o método PRISMA (Preferred Research Items for Systematic Review and Meta-Analyses). Foram analisados 172 artigos, dos quais 42 são estudos aplicados. Os resultados sugerem 26 fatores diferentes que influenciam a aceitação, sendo os benefícios mais importantes “melhor gerenciamento de energia através do feedback”, “eco-preocupação” e “expectativa de ganho financeiro”, já as barreiras mais relevantes são “segurança ameaçada”, “falta de familiaridade” e “custos associados”. As pesquisas de aceitação estão ainda muito concentradas na Europa, EUA e Austrália, sendo necessário que países em desenvolvimento, que lideram a expansão do uso de fontes renováveis em suas matrizes energéticas, também considerem investigar a aceitação local de medidores para obter sucesso em suas implementações.
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Kerimli, Elʹvin Gadzhi ogly, Adilya Novruz kyzy Aleskerova und Siradzheddin Veli ogly Serkerov. „SESQUITERPENE LACTONS FROM AERIAL PARTS OF ARTEMISIA CAMPESTRIS (var. MARSCHALLIANA) SPRENG.“ chemistry of plant raw material, Nr. 2 (10.06.2022): 129–35. http://dx.doi.org/10.14258/jcprm.20220210567.
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About 500 species of wormwood are known in the world. In the flora of Azerbaijan, this genus is represented by 42 taxa. The main chemicals in wormwood are shown to be sesquiterpene lactones, coumarins, steroids, and essential oils. From the aerial parts of Artemisia campestris (var. Marschalliana) Spreng., collected during the phenological phase of budding, an acetone extract was obtained, which, after removal of the solvent, was subjected to the column chromatography in neutral alumina oxide (II degree of activity) and eluted graduality with hexane, benzene, chloroform and their mixtures of increasing polarity. As a result of chromatographic separation, two sesquiterpene lactones of the eudesmann type were isolated - α-santonin (substance I) with m.p. 170–172 °С and artemisin (substance II) m.p. 201–203 °С. Moreover, an acetyl derivative of artemisin (substance III) with m.p. 196–198°C, the identification of which was carried out on the basis of physicochemical and spectral data (UV, IR, and 1H, 13C, 13C Dept 45, 13C Dept 90, 13C Dept 135 NMR spectra was obtained. Substances I and II are isolated from Artemisia campestris (var. Marschalliana) Spreng. for the first time.
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Martins, Mila Ferraz de Oliveira, Mariane Aparecida Nickele, Rodrigo Machado Feitosa, Marcio Roberto Pie und Wilson Reis-Filho. „Species list of ground-dwelling ants (Hymenoptera: Formicidae) in the Nhecolândia, Pantanal, Mato Grosso do Sul, Brazil“. Papéis Avulsos de Zoologia 61 (27.09.2021): e20216181. http://dx.doi.org/10.11606/1807-0205/2021.61.81.
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This study provides a list of the ground-dwelling ant species in Nhecolândia, Pantanal, Mato Grosso Sul, Brazil. The Pantanal is the largest tropical wetland in the world and is currently under strong anthropic pressure. Ground-dwelling ants were collected in three sites: (1) a forest regeneration area; (2) a pasture area; and (3) an area of secondary native vegetation. In each site, 120 samples were collected using pitfall traps in the dry and rainy seasons of 2016. Additional samplings were performed with Winkler extractors (30 leaf-litter samples) and manually, also in dry and rainy seasons of 2016. In total, we collected 172 species, which, summed with the additional records from literature, raise the number of ant species recorded in Nhecolândia to 184 in 42 genera and nine subfamilies. Eleven species were recorded for the first time in the state of Mato Grosso do Sul. Also, the survey adds two new species records to Brazil. Besides contributing to the inventory of the ant species present in the Pantanal biome, the present study provides an important resource for future conservation plans for this threatened ecoregion.