Zeitschriftenartikel: „128/.3“

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Leidlein, Sabryn, Jo-Ann Rammal, Howard Klausner und Jeffrey Johnson. „The Characterization of Trauma Patients Utilizing Private Vehicle Transport (PVT) to the Emergency Department (ED)“. Prehospital and Disaster Medicine 38, S1 (Mai 2023): s174. http://dx.doi.org/10.1017/s1049023x2300451x.

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Introduction:Existing studies have identified the national rate of PVT for severely injured patients to be 9-16%, our ED has displayed a PVT incidence of 35.4%, suggesting a substantial difference in ED arrival. This study aims to explore descriptive demographics and injury characteristics of patients who arrived by PVT to our ED.Method:A prospective, single-center observational study conducted in Detroit, Michigan. Included patients aged 15 ≥ years who arrived at the ED by PVT for blunt or penetrating trauma. The sample population consisted of 128 patients from August 2019-April 2021. Each subject completed a survey regarding their injury and prehospital care. A retrospective chart review was conducted to acquire information on their injuries.Results:The mean age was 44.3 ± 20.3 years old, range 15-93. 51/128 female, 77/128 male. Patients comprised 93/128 African American, 19/128 Caucasian, 4/128 Asian, 4/128 Hispanic/Latino, and 8/128 other. The most common insurance was Medicaid, comprising 63/128 patients, 25/128 of patients had Medicare and 38/128 had private coverage. Utilizing ESI indices to evaluate severity levels, 73/128 arrived at the ED with an ESI level of 3, 47/128 level of 2, 5/128 level of 4, and 3/128 level of 1, the most severe. Majority of patients 36/128, presented with trauma-related injuries due to a fall. 25/128 presented with a laceration, and 22/128 presented after a motor vehicle crash. The upper extremities were the most common location of trauma 38/128 followed by the lower extremities 23/128. The mean ED length of stay was 11.18 hours.Conclusion:Overall, the findings from this study allowed us to characterize our population of PVT trauma patients through their demographics and injury characteristics. We were able to establish some descriptive characteristics that delineate the population of patients at our ED in Detroit, which is the first step in identifying why trauma patients choose varying modes of transportation.

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Liu, Shinan, Shuai Gao, Zhaoyu Yang und Peng Zhang. „miR-128-3p reduced acute lung injury induced by sepsis via targeting PEL12“. Open Medicine 16, Nr. 1 (01.01.2021): 1109–20. http://dx.doi.org/10.1515/med-2021-0258.

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Abstract Objective Acute lung injury (ALI) caused by sepsis is clinically a syndrome, which is featured by damage to the alveolar epithelium and endothelium. In this study, we employed mice models of cecal ligation and puncture (CLP) and primary mice pulmonary microvascular endothelial cells (MPVECs) in vitro to investigate the effect of miR-128-3p in ALI caused by sepsis. Methods miR-128-3p agomir or randomized control were injected into adult male C57BL/6 mice 1 week before the CLP surgery. We used miR-128-3p agomir or scrambled control to transfect MPVECs and then employed lipopolysaccharide (LPS) stimulation on the cells. Pellino homolog 2 (PELI2) was predicted to be a direct target of miR-128-3p via luciferase reporter assay. MPVECs were cotransfected with lentiviral vector that expressed PELI2 (or empty vector) as well as miR-128-3p-mimics 1 day before LPS stimulation in rescue experiment. Transcriptional activity of caspase-3, cell apoptosis rate, and the expression levels of miR-128-3p, interleukin-1β (IL-1β), interleukin-6 (IL-6), and PELI2 were analyzed. Results Compared with the sham group, the lung of mice in the CLP group showed pulmonary morphological abnormalities, and the expression of IL-6 and IL-1β, caspase-3 activity, and apoptosis rate were significantly upregulated in the CLP group. Inflammatory factor levels and apoptosis rate were also significantly induced by LPS stimulation on MPVECs. Upregulation of miR-128-3p effectively inhibited sepsis-induced ALI, apoptosis as well as inflammation. miR-128-3p also played a role in antiapoptosis and anti-inflammation in MPVECs with LPS treatment. PEL12 upregulation in MPVECs alleviated miR-128-3p-induced caspase-3 activity inhibition and pro-inflammatory factor production. Conclusions miR-128-3p enabled to alleviate sepsis-induced ALI by inhibiting PEL12 expression, indicating a novel treatment strategy of miR-128-3p for sepsis-induced ALI.

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Lehtonen, S., V. P. Plessky, J. Koskela und M. M. Salomaa. „Second-harmonic reflectors on 128/spl deg/ LiNbO/sub 3/“. IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control 50, Nr. 8 (August 2003): 972–78. http://dx.doi.org/10.1109/tuffc.2003.1226541.

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LIÑÁN-CEMBRANO, G., S. ESPEJO, R. DOMÍNGUEZ-CASTRO und A. RODRÍGUEZ-VÁZQUEZ. „AN IMPROVED ELEMENTARY PROCESSING UNIT FOR HIGH-DENSITY CNN-BASED MIXED-SIGNAL MICROPROCESSORS FOR VISION“. Journal of Circuits, Systems and Computers 12, Nr. 06 (Dezember 2003): 675–90. http://dx.doi.org/10.1142/s0218126603001100.

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This paper presents the architecture of the Elementary Processing Unit — EPU — which has been employed to design a CNN-Based 128×128 Focal Plane Mixed-Signal Microprocessor for vision. The EPU contains the required building blocks to implement, on chip, vision algorithms based on the execution of linear 3×3 convolution masks,1 or information propagative CNN templates.2 Using this EPU, we have designed a prototype, called ACE16k, which contains an array of 128×128 EPUs and a completely digital interface, in a standard fully-digital 0.35 μm CMOS technology. The estimation results forecast 300 GOPS, 3.23 GOPS/mm2 and 100 GOP/J.

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Wrobbel, Sibylle, und Wolfgang Walker. „Rezension von: Walker, Wolfgang (Hrsg.), Schwäbischer Heimatkalender 2017“. Schwäbische Heimat 67, Nr. 4 (03.02.2022): 516. http://dx.doi.org/10.53458/sh.v67i4.1684.

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Liu, Yuanqin, Qinglu Zhang, Lingchong Liu, Cuiling Li, Rongwei Zhang und Guangcun Liu. „The Effect of Deep Learning-Based QSM Magnetic Resonance Imaging on the Subthalamic Nucleus“. Journal of Healthcare Engineering 2021 (15.09.2021): 1–7. http://dx.doi.org/10.1155/2021/8554182.

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In order to study the influence of quantitative magnetic susceptibility mapping (QSM) on them. A 2.5D Attention U-Net Network based on multiple input and multiple output, a method for segmenting RN, SN, and STN regions in high-resolution QSM images is proposed, and deep learning realizes accurate segmentation of deep nuclei in brain QSM images. Experimental results show data first cuts each layer of 0 100 case data, based on the image center, from 384 × 288 to the size of 128 × 128. Image combination: each layer of the image in the layer direction combines with two adjacent images into a 2.5D image, i.e., (It − m It; It + i), where It represents the layer i image. At this time, the size of the image changes from 128 × 128 to 128 × 128 × 3, in which 3 represents three consecutive layers of images. The SNR of SWP I to STN is twice that of SWI. The small deep gray matter nuclei (RN, SN, and STN) in QSM images of the brain and the pancreas with irregular shape and large individual differences in abdominal CT images can be automatically segmented.

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Chen, Shujun, und Bo Li. „MiR-128-3p Post-Transcriptionally Inhibits WISP1 to Suppress Apoptosis and Inflammation in Human Articular Chondrocytes via the PI3K/AKT/NF-κB Signaling Pathway“. Cell Transplantation 29 (01.01.2020): 096368972093913. http://dx.doi.org/10.1177/0963689720939131.

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In osteoarthritis (OA), the synthesis and decomposition of the extracellular matrix (ECM) are imbalanced. High expression levels of Wnt1-inducible signaling pathway protein 1 (WISP1) promote the synthesis of matrix metalloproteinases and induce the degradation of cartilage, which aggravates the OA. The aim of this study was to explore the role of miR-128-3p in the development of OA. In the present study, the expression of WISP1 and miR-128-3p in osteoarthritic tissues and chondrocytes was detected using quantitative reverse transcription PCR (RT-qPCR) and Western blotting. Then we predicted that WISP1 might be a potential target gene of miR-128-3p by TargetScan and verified using luciferase reporter gene assay. The effect of miR-128-3p or WISP1 on chondrocytes was evaluated by cell proliferation assay, apoptosis, and caspase-3 activity assay. To further reveal the molecular mechanisms of miR-128-3p in osteoarthritic development, the degradation of chondrocyte matrix and production of proinflammatory cytokines in osteoarthritic chondrocyte model were detected by ELISA. To mimic the osteoarthritic microenvironment in vitro studies, chondrocytes were stimulated with interleukin (IL)-1β, and then we found that the expression of miR-128-3p was downregulated. Overexpression of WISP1 inhibited the proliferation of chondrocytes, which induced apoptosis, degradation of chondrocyte matrix, production of proinflammatory cytokines, and activated the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt)/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway. Then, we identified that miR-128-3p was a negative regulator of WISP1 by directly targeting its 3′-untranslated region (UTR). Moreover, the PI3K allosteric activator 740 Y-P abolished the inhibition of miR-128-3p in apoptosis, degradation of chondrocyte matrix, and inflammation. Our results showed that miR-128-3p targets WISP1 to regulate chondrocyte proliferation, apoptosis, degradation of chondrocyte matrix, and production of proinflammatory cytokines via the PI3K/Akt/NF-κB pathway, which plays a suppressed role in OA.

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Brasseur, K., V. Leblanc, F. Fabi, S. Parent, C. Descôteaux, G. Bérubé und E. Asselin. „ERα-Targeted Therapy in Ovarian Cancer Cells by a Novel Estradiol-Platinum(II) Hybrid“. Endocrinology 154, Nr. 7 (15.05.2013): 2281–95. http://dx.doi.org/10.1210/en.2013-1083.

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Abstract As we previously showed, we have synthesized a new family of 17β-estradiol-platinum(II) hybrids. Earlier studies revealed the VP-128 hybrid to show high efficiency compared with cisplatin toward hormone-dependent breast cancer cells. In the present research, we have studied the antitumor activity of VP-128 in vitro and in vivo against ovarian cancer. In nude mice with ovarian xenografts, VP-128 displayed selective activity toward hormone-dependent tumors and showed higher efficiency than cisplatin to inhibit tumor growth. Similarly, in vitro, transient transfection of estrogen receptor (ER)-α in ERα-negative A2780 cells increased their sensitivity to VP-128-induced apoptosis, confirming the selectivity of VP-128 toward hormone-dependent tumor cells. In agreement, Western blot analysis revealed that VP-128 induced higher caspase-9, caspase-3, and poly (ADP-ribose) polymerase cleavage compared with cisplatin. The activation of caspase-independent apoptosis was also observed in ERα-negative A2780 cells, in which VP-128 rapidly induced the translocation of apoptosis-inducing factor to the nucleus. Conversely, subcellular localization of apoptosis-inducing factor was not modified in ERα-positive Ovcar-3 cells. We also discovered that VP-128 induces autophagy in ovarian cancer cells because of the formation of acidic vesicular organelles (AVOs) and increase of Light Chain 3B-II protein responsible for the formation of autophagosomes; pathways related to autophagy (AKT and mammalian target of rapamycin) were also down-regulated, supporting this mechanism. Finally, the inhibition of autophagy using chloroquine increased VP-128 efficiency, indicating a possible combination therapy. Altogether these results highlight the beneficial value of VP-128 for the treatment of hormone-dependent ovarian cancers and provide preliminary proof of concept for the efficient targeting of ERα- by 17β-estradiol-Pt(II)-linked chemotherapeutic hybrids in these tumors.

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Lehtonen, S., V. P. Plessky, N. Bereux und M. M. Salomaa. „Minimum-loss short reflectors on 128/spl deg/ LiNbO/sub 3/“. IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control 51, Nr. 10 (Oktober 2004): 1203–5. http://dx.doi.org/10.1109/tuffc.2004.1350945.

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Filby, A., M. Mitchell, A. Georgiou und M. Lane. „128. A ROLE FOR SIRTUIN 3 IN THE DEVELOPING MAMMALIAN EMBRYO“. Reproduction, Fertility and Development 21, Nr. 9 (2009): 47. http://dx.doi.org/10.1071/srb09abs128.

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Pre-implantation embryo development relies critically on the balance between cytoplasmic and mitochondrial metabolism for the generation of metabolic intermediates such as NAD+. SIRT3 is a mitochondrial sirtuin with NAD+-dependant deacetylase activity that, targets glutamate dehydrogenase (GDH). In this study we characterised SIRT3 mRNA, protein and activity through pre-implantation development and determined whether modulation of SIRT3 activity influenced GDH activity. Embryos (zygotes, 2-cell, 8-cell and blastocyst stages) were recovered from female CBA/C57Bl6 mice following ovarian stimulation and mating with CBA/C57Bl6 males. Expression of SIRT3 mRNA was measured using real-time RTPCR, protein localisation examined using immunohistochemistry and SIRT3 activity measured using a Fluor-de-Lys SIRT3 fluorescentassay. Functional GDH activity was assessed in 2-cell embryos indirectly by measuring glutamine oxidation, following culture from zygote to 2-cell in the presence of nicotinamide, (a sirtuin inhibitor), G1.2 media, or simpleG1 media, compared to in vivo controls. SIRT3 mRNA was detected at all stages of development, with significantly greater levels expressed in the blastocyst. SIRT3 protein was localised predominantly around the nucleus of zygote and 2-cell embryos, and was mainly cytoplasmic in 8-cell embryos and blastocysts. SIRT3 activity remained constant throughout pre-implantation development, and tended to increase at the blastocyst stage. Glutamine oxidation was reduced for embryos cultured in G1.2 media relative to in vivo controls (0.14 pmol/e/hr vs 0.21pmol/e/hr), and this was further reduced by the addition of nicotinamide (0.07pmol/e/hr). Embryo culture in perturbing simpleG1 increased glutamine metabolism (0.33pmol/e/hr). In conclusion, SIRT3 mRNA, protein and activity was detected throughout pre-implantation development. Modulation of sirtuins by nicotinamide decreased glutamine metabolism, likely as a result of decreased deacetylation, thus decreased activity of GDH. SIRT3 can translocate to the mitochondria during cellular stress, thus the increased glutamine metabolism in simpleG1 conditions may be caused by translocation of SIRT3 to mitochondria, potentially increasing GDH deacetylation and enzymatic activity.

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Song, Junghwan, Kwanhyung Lee und Hwanjin Lee. „Biclique Cryptanalysis on the Full Crypton-256 and mCrypton-128“. Journal of Applied Mathematics 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/529736.

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Biclique cryptanalysis is an attack which reduces the computational complexity by finding a biclique which is a kind of bipartite graph. We show a single-key full-round attack of the Crypton-256 and mCrypton-128 by using biclique cryptanalysis. In this paper, 4-round bicliques are constructed for Crypton-256 and mCrypton-128. And these bicliques are used to recover master key for the full rounds of Crypton-256 and mCrypton-128 with the computational complexities of 2253.78and 2126.5, respectively. This is the first known single-key full-round attack on the Crypton-256. And our result on the mCrypton-128 has superiority over known result of biclique cryptanalysis on the mCrypton-128 which constructs 3-round bicliques in terms of computational time complexity.

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Schreiber, Sandra, Patrick Daum, Heike Danzer, Manuela Hauke, Hans-Martin Jäck und Jürgen Wittmann. „Identification of miR-128 Target mRNAs That Are Expressed in B Cells Using a Modified Dual Luciferase Vector“. Biomolecules 13, Nr. 10 (13.10.2023): 1517. http://dx.doi.org/10.3390/biom13101517.

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MicroRNAs (miRNAs) are 21–25 nucleotide long non-coding ribonucleic acids that modulate gene expression by degrading transcripts or inhibiting translation. The miRNA miR-128, originally thought to be brain-specific, was later also found in immune cells. To identify a valuable immune cell model system to modulate endogenous miR-128 amounts and to validate predicted miR-128 target mRNAs in B cells, we first investigated miR-128 expression using Northern blot analysis in several cell lines representing different stages of B cell development. The results showed that only primary brain cells showed significant levels of mature miR-128. To study the function of miR-128 in immune cells, we modified dual luciferase vectors to allow easy transfer of 3′ UTR fragments with predicted miR-128 binding sites from widely used single to dual luciferase vectors. Comparison of in silico predicted miR-128-regulated mRNAs in single and dual luciferase constructs yielded similar results, validating the dual luciferase vector for miRNA target analysis. Furthermore, we confirmed miR-128-regulated mRNAs identified in silico and in vivo using the Ago HITS-CLIP technique and known to be expressed in B cells using the dual luciferase assay. In conclusion, this study provides new insights into the expression and function of miR-128 by validating novel target mRNAs expressed in B cells and identifying additional pathways likely controlled by this miRNA in the immune system.

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Pistilli, Barbara, Hans Wildiers, Erika Paige Hamilton, Ana Alexandra Ferreira, Florence Dalenc, Maria Vidal, Joaquín Gavilá et al. „Clinical activity of MCLA-128 (zenocutuzumab) in combination with endocrine therapy (ET) in ER+/HER2-low, non-amplified metastatic breast cancer (MBC) patients (pts) with ET-resistant disease who had progressed on a CDK4/6 inhibitor (CDK4/6i).“ Journal of Clinical Oncology 38, Nr. 15_suppl (20.05.2020): 1037. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.1037.

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1037 Background: MCLA-128 (zenocutuzumab) is an ADCC-enhanced humanized bispecific antibody targeting HER2 and HER3 and potently blocking HER3-ligand induced receptor dimerization. Upregulation of Her2:Her 3 pathway is a means of resistance to ET in HR+ breast cancer, indicating a potential role for MCLA-128. In preclinical studies, the combination of MCLA-128 with ET in breast cancer xenografts outperformed single drug treatments. The current study explores the use of MCLA-128 to rescue pts with ET-resistant MBC who have progressed on a CDK4/6i. Methods: This phase II, open-label trial planned for up to 40 evaluable women with HR+, HER2 low (IHC 1+/IHC 2+ with negative FISH) MBC, who had progressed on a CDK4/6i and up to 3 lines of ET, who had received ≤ 2 chemotherapy regimens in the metastatic setting. Pts received MCLA-128 (750 mg, 2h IV, flat dose) q3w combined with last ET on which the pt had previously progressed immediately prior to study entry. Disease control rate (DCR; RECIST 1.1, per investigator), best overall response (BOR), overall response rate (ORR), safety, and PK, are evaluated. Data cut off was 14Nov2019. Results: 48 pts were treated, all of whom had progressed on a CDK4/6i. Pts had received a median 2 prior ET lines (range 1-5) and 1 line (range 1-3) of chemotherapy. Pts had a median number of 3 metastatic sites (range 1-6) and 42 (88%) had visceral involvement. Among 42 pts evaluable for efficacy, DCR was 45% (90% CI 32-59) with 2 pts having unconfirmed PR and 19 pts SD as BOR. Common related AEs (all grades; G3-4) were asthenia/fatigue (27%; 2%), diarrhea (25%; 0), nausea (21%; 0). No clinically significant LVEF decline was seen. At the end of cycle 1, mean trough level of MCLA-128 was 15.5 µg/mL, and mean terminal half-live was 102 h (n = 19-21). Data on the primary endpoint, clinical benefit rate at 24 weeks, and biomarkers will be provided. Conclusions: The addition of MCLA-128 to the last line of ET showed clinical activity after ET+CDK4/6i failure and a favorable safety profile. Clinical trial information: NCT03321981 .

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Yang, Fengzhen, Qi Zhao, Lipeng Wang, Jinying Wu, Lihua Jiang, Li Sheng, Leyan Zhang, Zhaoping Xue und Maoli Yi. „Diminished Susceptibility to Cefoperazone/Sulbactam and Piperacillin/Tazobactam in Enterobacteriaceae Due to Narrow-Spectrum β-Lactamases as Well as Omp Mutation“. Polish Journal of Microbiology 71, Nr. 2 (01.06.2022): 251–56. http://dx.doi.org/10.33073/pjm-2022-023.

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Abstract Cefoperazone/sulbactam (CSL) and piperacillin/tazobactam (TZP) are commonly used in clinical practice in China because of their excellent antimicrobial activity. CSL and TZP-nonsusceptible Enterobacteriaceae are typically resistant to extended-spectrum cephalosporins such as ceftriaxone (CRO). However, 11 nonrepetitive Enterobacteriaceae strains, which were resistant to CSL and TZP yet susceptible to CRO, were collected from January to December 2020. Antibiotic susceptibility tests and whole-genome sequencing were conducted to elucidate the mechanism for this rare phenotype. Antibiotic susceptibility tests showed that all isolates were amoxicillin/clavulanic-acid resistant and sensitive to ceftazidime, cefepime, cefepime/tazobactam, cefepime/zidebactam, ceftazidime/avibactam, and ceftolozane/tazobactam. Whole-genome sequencing revealed three of seven Klebsiella pneumoniae strains harbored bla SHV-1 only, and four harbored bla SHV-1 and bla TEM-1B. Two Escherichia coli strains carried bla TEM-1B only, while two Klebsiella oxytoca isolates harbored bla OXY-1-3 and bla OXY-1-1, respectively. No mutation in the β-lactamase gene and promoter sequence was found. Outer membrane protein (Omp) gene detection revealed that numerous missense mutations of OmpK36 and OmpK37 were found in all strains of K. pneumoniae. Numerous missense mutations of OmpK36 and OmpK35 and OmpK37 deficiency were found in one K. oxytoca strain, and no OmpK gene was found in the other. No Omp mutations were found in E. coli isolates. These results indicated that narrow spectrum β-lactamases, TEM-1, SHV-1, and OXY-1, alone or in combination with Omp mutation, contributed to the resistance to CSL and TZP in CRO-susceptible Enterobacteriaceae. Antibiotic susceptibility tests Antibiotics Breakpoint, (μg/ml) Klebsiella pneumoniae Escherichia cou Klebriehd axyoca E1 E3 E4 E7 E9 E10 E11 E6 E8 E2 E5 CRO ≤1≥4 ≤0.5 ≤0.5 ≤0.5 ≤0.5 1 ≤0.5 1 ≤0.5 ≤0.5 1 1 CAZ 4 ≥16 1 2 1 4 4 4 4 2 4 1 1 FEP ≤2 216 1 1 0.25 1 2 2 2 0.5 2 1 1 AMC ≤8 ≥32 ≥128 ≥128 ≥128 ≥128 ≥128 ≥128 ≥128 ≥128 ≥128 ≥128 ≥128 CSL ≤16 ≥64 64 64 64 64 ≥128 128 ≥128 64 128 128 ≥128 TZP ≤16 ≥128 ≥256 ≥256 ≥256 ≥256 2256 2256 ≥256 ≥256 ≥256 ≥256 ≥256 FPT ≤2 ≥16 1 0.5 0.06 0.125 2 1 2 0.25 1 0.125 0.25 FPZ ≤2 216 0.25 0.25 0.06 0.125 0.25 0.25 1 0.125 0.25 0.125 0.125 CZA ≤8 216 1 0.5 0.25 0.25 1 0.25 1 0.5 0.5 0.5 0.25 CZT ≤2 28 2 1 0.5 1 2 2 2 1 1 2 2 CROceftriaxone, CAZceftazidime, FEPcefepime, AMC:amoxicillin clavulanic-acid, CSLcefoperazone/sulbactam, TZP:piperadllin/tazobactam, FPT:cefepime tazobactam, FPZ:cefepime/zidebactam, CZA:ceftazidime/avibactam, CZTceftolozane/tazobactam Gene sequencing results Number Strain ST p-Lactamase gene Promoter sequence mutation Omp mutation El Kpn 45 blaSHV-1, blaTEM-lB none OmpK36, OmpK3 7 E3 Kpn 45 blaSHV-1, blaTEM-lB none OmpK36. OmpK3 7 E4 Kpn 2854 blaSHV-1 none OmpK36, OmpK3 7 E7 Kpn 2358 blaSHV-1 - blaTEM-lB none OmpK36, OmpK3 7 E9 Kpn 2358 blaSHV-1. blaTEM-lB none OmpK36. OmpK3 7 E10 Kpn 18 9 blaSHV-1 none OmpK36. OmpK3 7 Ell Kpn 45 blaSHV-1 none OmpK36, OmpK3 7 E6 Eco 88 blaTEM-lB none none ES Eco 409 blaTEM-1B none none E2 Kox 194 blaOXY-1-3 none OmpK36 mutations. OmpK35 and OmpK 37 deficiency E5 Kox 11 blaOXY-1-1 none no OmpK (OmpK3 5, OmpK36 and OmpK37) gene found

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Yang, Peng, Jianhua Han, Shigeng Li, Shaoning Luo, Xusheng Tu und Zhiqiang Ye. „miR-128-3p inhibits apoptosis and inflammation in LPS-induced sepsis by targeting TGFBR2“. Open Medicine 16, Nr. 1 (01.01.2021): 274–83. http://dx.doi.org/10.1515/med-2021-0222.

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Abstract Background Sepsis is a systemic inflammatory response that can lead to the dysfunction of many organs. The aberrant expression of miRNAs is associated with the pathogenesis of sepsis. However, the biological functions of miR-128-3p in sepsis remain largely unknown, and its mechanism should be further investigated. This study aimed to determine the regulatory network of miR-128-3p and TGFBR2 in lipopolysaccharide (LPS)-induced sepsis. Methods The expression levels of miR-128-3p and transforming growth factor beta receptors II (TGFBR2) were detected by quantitative polymerase chain reaction (qPCR). The protein levels of TGFBR2, Bcl-2, Bax, cleaved caspase 3, Smad2, and Smad3 were measured by western blot. Cell apoptosis was analyzed by flow cytometry. Cytokine production was detected by enzyme-linked immunosorbent assay (ELISA). The binding sites of miR-128-3p and TGFBR2 were predicted by Targetscan online software and confirmed by dual-luciferase reporter assay and RNA immunoprecipitation (RIP) assay. Results The level of miR-128-3p was decreased, and TGFBR2 expression was increased in serum samples of sepsis patients and LPS-induced HK2 cells. Overexpression of miR-128-3p or knockdown of TGFBR2 ameliorated LPS-induced inflammation and apoptosis. Moreover, TGFBR2 was a direct target of miR-128-3p, and its overexpression reversed the inhibitory effects of miR-128-3p overexpression on inflammation and apoptosis in LPS-induced HK2 cells. Besides, overexpression of miR-128-3p downregulated TGFBR2 to suppress the activation of the Smad signaling pathway. Conclusion miR-128-3p could inhibit apoptosis and inflammation by targeting TGFBR2 in LPS-induced HK2 cells, which might provide therapeutic strategy for the treatment of sepsis.

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Hamilton, Erika Paige, Thierry Petit, Barbara Pistilli, Anthony Goncalves, Ana Alexandra Ferreira, Florence Dalenc, Fatima Cardoso et al. „Clinical activity of MCLA-128 (zenocutuzumab), trastuzumab, and vinorelbine in HER2 amplified metastatic breast cancer (MBC) patients (pts) who had progressed on anti-HER2 ADCs.“ Journal of Clinical Oncology 38, Nr. 15_suppl (20.05.2020): 3093. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.3093.

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3093 Background: MCLA-128 (zenocutuzumab ), a HER3 pathway inhibitor, is a humanized bispecific full-length IgG1 antibody targeting both HER2 and HER3 with enhanced ADCC activity. The unique Dock & Block mechanism inhibits HER3 from interacting with its ligands and targets HER2 at a different epitope than trastuzumab, blocking HER2/HER3 dimerization and downstream PI3K/AKT/mTOR signaling. In MBC, HER3 overexpression and/or HER3 ligand upregulation are important drivers leading to trastuzumab resistance, indicating a role for MCLA-128. Preclinical activity was seen in HER2+ breast models when MCLA-128 was combined with trastuzumab. Furthermore, single agent MCLA-128 showed consistent antitumor activity in heavily pretreated HER2+ MBC pts. A phase 2, open-label study explored the MCLA-128/trastuzumab plus vinorelbine triplet in an MBC population. Methods: This open-label trial planned for up to 40 evaluable women with HER2+/amplified MBC progressing on up to 5 anti-HER2 lines including trastuzumab, pertuzumab and an anti-HER2 ADC. Pts received MCLA-128 (750 mg, 2h IV), trastuzumab (8 mg/kg loading, then 6 mg/kg) and vinorelbine (25 mg/m², D1 and 8), q3w. A safety run-in of MCLA-128 + trastuzumab ± chemotherapy was performed. Disease control rate (DCR; RECIST 1.1, per investigator), best overall response (BOR), overall response rate (ORR), safety, and PK are evaluated. Data cutoff was 14Nov2019. Results: 28 pts with a median 3 lines (range 2-5) of anti-HER2 therapy (metastatic setting) and 3 (range 1-6) metastatic sites, received a median of 5 (range 1-17) MCLA-128 cycles. Among 26 pts evaluable for efficacy, 20 patients had CR/PR/SD as BOR; DCR was 77% (90%CI: 60-89) with 1 confirmed CR and 4 PRs (2 unconfirmed). Common related AEs (all grades; G3-4) were neutropenia/neutrophil count decrease (61%; 46%), diarrhea (61%; 4%), asthenia/fatigue (46%; 0), nausea (29%; 0). No clinically significant LVEF decline was seen. At the end of cycle 1, mean trough levels of MCLA-128 was 19.1 µg/mL, and mean terminal half-life was 112 h (n = 8-11). Data on the primary endpoint, clinical benefit rate at 24 weeks, and biomarkers will be provided. Conclusions: The triplet MCLA-128-based combination is active in heavily pretreated pts with HER2+/amplified MBC. The regimen is safe and well tolerated with a manageable AE profile mostly related to the chemotherapy component. Clinical trial information: NCT03321981 .

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Mou, Tong, Yunhai Luo, Zuotian Huang, Daofeng Zheng, Xingyu Pu, Ai Shen, Junliang Pu et al. „Inhibition of microRNA-128-3p alleviates liver ischaemia–reperfusion injury in mice through repressing the Rnd3/NF‐κB axis“. Innate Immunity 26, Nr. 6 (02.06.2020): 528–36. http://dx.doi.org/10.1177/1753425920928449.

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Although liver ischaemia–reperfusion (I/R) injury remains the primary underlying reason for liver transplant failure or post-transplantation liver dysfunction, the underlying mechanism is still largely elusive. MicroRNAs (miRNA) are involved in multiple physiological and pathological processes, including inflammation. Here, we identified that the miR-128-3p/Rho family GTPase 3 (Rnd3)/NF‐κB axis might play a critical role in liver I/R injury. Our results demonstrated that the level of miR-128-3p was negatively correlated with the Rnd3 level during liver I/R. Dual luciferase reporter assay results proved that Rnd3 mRNA was a direct target of miR-128-3p. Additionally, Western blotting and quantitative RT-PCR analyses revealed that knock-down of miR-128-3p could up-regulate Rnd3 mRNA and protein levels, thereby suppressing the NF-κB pathway through down-regulating NF‐κB p65. Consequently, the serum levels of NF-κB–associated inflammatory factors and aspartate aminotransferase/alanine aminotransferase were decreased. Moreover, overexpression of Rnd3 could reverse the activation of NF-κB caused by miR-128-3p agomir during liver I/R injury. Overall, our study results suggest that repression of miR-128-3p can alleviate liver I/R injury through the miR-128-3p/Rnd3/NF‐κB axis and may facilitate the development of novel protective approaches against liver I/R injury.

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Soeetomenggolo, Taslim S. „Blood Bilirubin Content in Neonatal Tetanus Patient with Hyperbilirubinemia during Treatment with Intravenous Diazepam“. Paediatrica Indonesiana 32, Nr. 3-4 (28.01.2019): 59–64. http://dx.doi.org/10.14238/pi32.3-4.1992.59-64.

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An evaluation on 128 neonatal tetanus patients with hyperbilirubinemia was done at the Department of Child Health, Dr. Cipto Mangunkusumo General Hospital, Jakarta. The patients were treated with high dosages of diazepam intravenously. This drug is potential to cause the increase of blood bilirubin, and in turn this latter condition is potential to cause kernicterus. Of the 128 patients there were 70 males and 58 females. The age of the patients were mostly (79.6 %) 4- 7 days. Fourteen of the 128 patients showed the increase of their blood bilirubin content during the second day of treatment, but after that it declined gradually during the next 3 days. The mortality of the 14 patients was 8 (57.1 %), so far no kernicterus was recorded among them. Among the 128 patients, 114 patients showed the decrease of their blood bilirubin content during the treatment. During 3 days the blood bilirubin content became less than 10 mg/dL. No kernicterus was recorded among those patients. It was concluded that intravenous diazepam is not dangerous in patients with mild and moderate hyperbilirubinemia, and no kernicterus was recorded during evaluation.

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Serrano-Gotarredona, Teresa, und Bernabé Linares-Barranco. „A 128$\,\times$128 1.5% Contrast Sensitivity 0.9% FPN 3 µs Latency 4 mW Asynchronous Frame-Free Dynamic Vision Sensor Using Transimpedance Preamplifiers“. IEEE Journal of Solid-State Circuits 48, Nr. 3 (März 2013): 827–38. http://dx.doi.org/10.1109/jssc.2012.2230553.

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Editorial, Article. „Erratum: E. A. Sokova et al., Risk factors and characteristics of adverse reactions associated with the use of beta-lactam antibiotics in older patients“. Safety and Risk of Pharmacotherapy 9, Nr. 4 (03.12.2021): 218. http://dx.doi.org/10.30895/2312-7821-2021-9-4-218-218.

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Sоkоvа Е.А., Arkhipov V.V., Demidova O.A., Mazerkina I.A., Alexandrova T.V., Zhuravleva M.V. Risk factors and characteristics of adverse reactions associated with the use of beta-lactam antibiotics in older patients. Bezopasnost’ i risk farma koterapii = Safety and Risk of Pharmacotherapy. 2021;9(3):128–135. https://doi.org/10.30895/2312-7821-2021-9-3-128-135Dear readers, a technical error was made on page 134, issue 3 of the Safety and Risk of Pharmacotherapy, 2021 (2021;9(3):128–135). The following statement:“Acknowledgements. The study reported in this publication was carried out as part of a publicly funded research project No. 056-00005-21-00 and was supported by the Scientific Centre for Expert Evaluation of Medicinal Products (R&D public accounting No. 121021800098-4)”should read:“Acknowledgements. The study reported in this publication was carried out as part of a publicly funded research project No. 056-00005-21-00 and was supported by the Scientific Centre for Expert Evaluation of Medicinal Products (R&D public accounting No. 121022000154-2)”.The correction did not have any effect on the conclusions made by the authors.The text of the online version of the journal was corrected accordingly.

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Caggiano, Rocco, Fabio Cattaneo, Ornella Moltedo, Giovanni Esposito, Cinzia Perrino, Bruno Trimarco, Rosario Ammendola und Raffaella Faraonio. „miR-128 Is Implicated in Stress Responses by Targeting MAFG in Skeletal Muscle Cells“. Oxidative Medicine and Cellular Longevity 2017 (2017): 1–13. http://dx.doi.org/10.1155/2017/9308310.

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MAFG (v-Maf avian musculoaponeurotic fibrosarcoma oncogene homolog G) is a bZIP-type transcriptional regulator that belongs to the small MAF (sMAFs) protein family. By interacting with other bZIP transcription factors, sMAFs can form homo- and heterodimers governing either repressive or activating transcriptional functions. As heterodimeric partner of Nrf2, MAFG positively influences the ARE-dependent antioxidant/xenobiotic pathways, at least in condition of a correct MAFG:Nrf2 balance. MicroRNAs (miRs) participate to different regulatory networks being involved as fine-tuning regulators of gene expression. However, the connections between cellular surveillance to stresses mediated by MAFG:Nrf2 and miR regulations are not well understood. Here, we explored the impact of miR-128 in expression of genes related to stress response. Bioinformatic predictions coupled with functional analysis revealed the presence of miR-128 binding site in the 3′UTR of MAFG. Ectopic miR-128 expression correlated with reduced expression of endogenous MAFG-dependent genes and negatively affected ARE-mediated molecular phenotype based on Nrf2 activity. Indeed, miR-128 impairs redox-dependent pathways induced in response to oxidative stress. Moreover, in condition of hypoxia, MAFG induction correlated with reduced levels of miR-128. This lead to increased mRNA levels of HMOX-1 and x-CT for blunting stress. Overall, these findings identify MAFG as novel direct target of miR-128.

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El Hadj Youssef, Wajih, Ali Abdelli, Fethi Dridi und Mohsen Machhout. „Hardware Implementation of Secure Lightweight Cryptographic Designs for IoT Applications“. Security and Communication Networks 2020 (29.11.2020): 1–13. http://dx.doi.org/10.1155/2020/8860598.

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The recent expansion of the Internet of Things is creating a new world of smart devices in which security implications are very significant. Besides the claimed security level, the IoT devices are usually featured with constrained resources, such as low computation capability, low memory, and limited battery. Lightweight cryptographic primitives are proposed in the context of IoT while considering the trade-off between security guarantee and good performance. In this paper, we present optimized hardware, lightweight cryptographic designs, of 32-bit datapath, LED 64/128, SIMON 64/128, and SIMECK 64/128 algorithms, for constrained devices. Our proposed designs are investigated on Spartan-3, Spartan-6, and Zynq-7000 FPGA platforms in terms of area, speed, efficiency, and power consumption. The proposed designs achieved a high throughput up to 891.99 Mbps, 838.95 Mbps, and 210.13 Mbps for SIMECK 64/128, SIMON 64/128, and LED 64/128 on Zynq-7000, respectively. A deep comparison between our three proposed designs is elaborated on different FPGA families for adequate FPGAs-based application deployment. Test results and security analysis show that not only can our proposed designs achieve good encryption results with high performance and a low reduced cost but also they are secure enough to resist statistical attacks.

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Lachowski, Jerzy. „Przestępstwo wywierania wpływu na czynności urzędowe konstytucyjnego organu RP (art. 128 §3 kk)- wybrane zagadnienia sporne“. Studia z zakresu nauk prawnoustrojowych. Miscellanea IX (19.12.2019): 167–83. http://dx.doi.org/10.5604/01.3001.0013.7201.

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Przestępstwo wywierania wpływu na konstytucyjne organy RP, stypizowane w art. 128§3kk zwraca uwagę zwłaszcza w kontekście takich wydarzeń, jak choćby blokowanie mównicy sejmowej przez posłów opozycji podczas 33. posiedzenia Sejmu i zmuszenie Marszałka Sejmu do przeniesienia obrad do sali kolumnowej. Rodzi się również pytanie, czy blokowanie możliwości wyjazdu z terenu sejmu realizuje znamiona opisane w ww. przepisie. Kwestie te można rozstrzygnąć po przeanalizowaniu strony przedmiotowej przestępstwa z art. 128§3kk, zwłaszcza po rozważeniu czy zachowania takie realizują znamię przemocy. Trzeba jednak wskazać, że nie tylko ten element rzeczonego przestępstwa wywołuje wątpliwości i spory w doktrynie prawa karnego. Nie jest wszak jasne, czy do istoty groźby bezprawnej, charakteryzującej sposób zachowania sprawcy przestępstwa z art. 128§3kk należy obiektywne wywołanie obawy jej spełnienia. Wątpliwości budzi także sam charakter prawny tego przestępstwa, nie ma bowiem zgody w literaturze co do materialnego czy też formalnego jego charakteru. Wreszcie spory dotyczą także przedmiotu czynności na gruncie tego przepisu, który raz ujmowany jest szerzej, a raz węziej.

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Wei, Wei, Yang Jie Zhou, Ju Lian Shen, Lu Lu, Xin Ru Lv, Tao Tao Lu, Pei Tao Xu und Xie Hua Xue. „The Compatibility of Alisma and Atractylodes Affects the Biological Behaviours of VSMCs by Inhibiting the miR-128-5p/p21 Gene“. Evidence-Based Complementary and Alternative Medicine 2022 (07.07.2022): 1–13. http://dx.doi.org/10.1155/2022/7617258.

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Objective. The compatibility of Alisma and Atractylodes (AA) has been estimated to exhibit antiatherosclerotic effects, but the mechanism remains unclear. This study aimed to identify the role of AA in oxidized low-density lipoprotein (ox-LDL)-induced vascular smooth muscle cell (VSMC) behaviours and to explore the effects of microRNAs (miRNAs). Methods. A scratch wound-healing assay was used to detect the migration of VSMCs, and immunocytochemistry and western blotting for SM22ɑ were used to evaluate phenotypic transformation. Bromodeoxyuridine (BrdU) immunocytochemistry and flow cytometry were applied to detect the proliferation of VSMCs. miRNA microarray profiling was performed using Lianchuan biological small RNA sequencing analysis. VSMCs were transfected with the miR-128-5p mimic and inhibitor, and the migration, phenotypic modulation, and proliferation of VSMCs were investigated. The 3′UTR-binding sequence site of miR-128-5p on the p21 gene was predicted and assessed by luciferase assays. Result. AA and the extracellular regulated protein kinase 1/2 (ERK1/2) blocker U0126 markedly inhibited migration, elevated smooth muscle 22α (SM22α) expression, repressed VSMC proliferation, elevated miR-466f-3p and miR-425-3p expression, and suppressed miR-27a-5p and miR-128-5p expression in ox-LDL-induced VSMCs. miR-128-5p targets the tissue inhibitor of metalloproteinases (TIMPs), silent information regulator 2 (SIRT2), peroxisome proliferator-activated receptor (PPAR), and p21 genes, which are linked to the behaviours of VSMCs. The miR-128-5p mimic promoted the migration and proliferation of VSMCs and suppressed p21, p27, and SM22ɑ expression. The inhibitor increased p21, p27, and SM22ɑ expression and repressed the migration, phenotypic transformation, and proliferation of VSMCs. miR-128-5p directly targeted the 3′UTR-binding sequences of the p21 gene, negatively regulated p21 expression, and supported the proliferation of VSMCs. Conclusion. Our research showed that the migration, phenotypic transformation, and proliferation of ox-LDL-induced VSMCs were repressed by AA through inhibiting miR-128-5p by targeting the p21 gene, which may provide an effective option for the treatment of atherosclerosis.

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Ногай, А., С. Стефанович, Ж. Салиходжа und А. Ногай. „Проводящие и диэлектрические свойства Na 3 Sc 2 (PO 4 ) 3“. BULLETIN OF THE L.N. GUMILYOV EURASIAN NATIONAL UNIVERSITY PHYSICS. ASTRONOMY SERIES 128, Nr. 3 (05.07.2022): 128–37. http://dx.doi.org/10.32523/2616-6836-2019-128-3-128-137.

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В данной статье изучены проводящие и диэлектрические свойства поликристалла Na 3 Sc 2 (PO 4 ) 3 , который имеет три полиморфные α –, β –, γ – фазы.Уточнены особенности строения кристалла α –Na 3 Sc 2 (PO 4 ) 3 , а также дипольного упорядочения и релаксационной поляризации в α и β –фазах. Возникновение дипольного упорядочения в α – фазе и частичного разупорядочения в β –Na 3 Sc 2 (PO 4 ) 3 , а также высокой ионной проводимости в β –, γ – фазах кристалла Na 3 Cr 2 (PO 4 ) 3 связано фазовыми превращениями α → β , β → γ , приводящими к структурным изменениям ромбоэдрического кристаллического каркаса {[M 2 (PO 4 ) 3 ] 3− } 3∞ . Предложена модель, поясняющая проводящие и диэлектрические свойства Na 3 Sc 2 (PO 4 ) 3 .

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Wrobbel, Sibylle, und Wolfgang Walker. „Rezension von: Walker, Wolfgang (Hrsg.), Schwäbischer Heimatkalender 2009“. Schwäbische Heimat 59, Nr. 4 (14.07.2022): 490–91. http://dx.doi.org/10.53458/sh.v59i4.3376.

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Schwäbischer Heimatkalender 2009. Herausgegeben von Wolfgang Walker. 120. Jahrgang. W. Kohlhammer Verlag Stuttgart 2008. 128 Seiten mit zahlreichen Abbildungen. Kartoniert € 9,90. ISBN 978-3-17-020190-3

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Lu, Weiqun, Jia Wang, Guohua Yang, Nanrong Yu, Zhiliang Huang, Houwei Xu, Jianchang Li et al. „Posttranscriptional regulation of Galectin-3 by miR-128 contributes to colorectal cancer progression“. Oncotarget 8, Nr. 9 (27.01.2017): 15242–51. http://dx.doi.org/10.18632/oncotarget.14839.

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Jaklin, Martina. „Anmerkung zu OLG Zweibrücken, Beschl. v. 21.1.2016 – 3 W 128/15 (AG Mainz)“. Medizinrecht 34, Nr. 10 (Oktober 2016): 801. http://dx.doi.org/10.1007/s00350-016-4410-2.

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Van Themsche, Céline, Sophie Parent, Valérie Leblanc, Caroline Descôteaux, Anne-Marie Simard, Gervais Bérubé und Eric Asselin. „VP-128, a novel oestradiol-platinum(II) hybrid with selective anti-tumour activity towards hormone-dependent breast cancer cells in vivo“. Endocrine-Related Cancer 16, Nr. 4 (Dezember 2009): 1185–95. http://dx.doi.org/10.1677/erc-09-0113.

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We have previously reported the synthesis of VP-128, a new 17β-oestradiol (E2)-linked platinum(II) hybrid with high affinity for oestrogen receptor α (ERα). In the present study, we have investigated the anti-tumour activity of VP-128 towards breast cancer cells in vitro and in vivo. We used human ERα-positive (MCF-7) and -negative (MDA-MB-468) cells as a model for treatment with increasing doses of VP-128, cisplatin or E2 in vitro and for xenograft experiments in nude mice in vivo. Compared with cisplatin, VP-128 showed markedly improved in vitro and in vivo anti-tumour activity towards ERα-positive MCF-7 breast cancer cells, without increased systemic toxicity. In these caspase-3-deficient cells, treatment with VP-128 overcame weak cellular sensitivity to cisplatin in vitro and in vivo. In these cells, only the hybrid induced apoptosis in an ERα-dependent manner, inactivated both X-linked inhibitor of apoptosis protein and Akt, and induced selective nuclear accumulation of ERα and the expression of ER-regulated genes c-myc and tff1, which was blocked by ERα-specific antagonist ICI 282 780. In the case of ERα-negative MDA-MB-468 cells, VP-128, but not cisplatin, induced nuclear accumulation of apoptosis-inducing factor and inhibited c-myc expression. However, VP-128 did not show enhanced in vivo anti-tumour activity compared with cisplatin. These results reveal two different modes of action for VP-128 in ERα-positive and -negative breast cancer cells, and highlight the promising therapeutic value of this unique E2-platinum hybrid for selective targeting of hormone-dependent cancers.

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Desai, Nirav, und Parag Shukla. „Performance of Deep Learning in Land Use Land Cover Classification of Indian Remote Sensing (IRS) LISS – III Multispectral Data“. International Journal on Recent and Innovation Trends in Computing and Communication 11, Nr. 3 (04.04.2023): 128–34. http://dx.doi.org/10.17762/ijritcc.v11i3.6329.

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Identification of land use land cover is a very important task. However, methods existing for the above mention purpose are labor incentives, time-consuming, and costly. Remote sensing plays very important role in the mappings. classification of land cover features and offers very noteworthy and sensed information. The present study shows the semantic segmentation of Indian remote sensing (IRS) LISS-III multispectral image and the comparison of three algorithms U-Net, Deeplabv3+and Tiramisu. The deep neural network was used to perform the study. We present total 3 innovative datasets, built on these LISS-III images that has 4 different spectral bands (Band – 2 (Blue), Band-3 (Green), Band-4(Red), and Band-5 (Nearly Infrared), FCC (false color composite) images and the ground truth mask images. Dataset has 13500 labelled images. A fully-convolutional network (FCN) with skip connections is trained to take an input image of size 128 X 128 X 3 and outputs a matrix of shape 128 X 128 X 4 i.e., a one-hot encoded version of the mask. The experiment identifies 4 classes successfully (Water Bodies, Vegetation, Uncultivated Land, and Residential areas). The experiment showed that the U-Net algorithm has a very good capability for the classification of LISS -III images for land use land cover class detection then Tiramisu and Deeplabv3+. U-Net achieved accuracy 84%, Deelabv3+ achieved 29% whereas Tiramisu achieved accuracy 33%.

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Resende, Geraldo M. de, Jony E. Yuri, José H. Mota, Rovilson J. de Souza, Silvio A. C. de Freitas und Juarez C. Rodrigues Junior. „Efeitos de tipos de bandejas e idade de transplantio de mudas sobre o desenvolvimento e produtividade da alface americana“. Horticultura Brasileira 21, Nr. 3 (September 2003): 558–63. http://dx.doi.org/10.1590/s0102-05362003000300029.

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Avaliou-se a influência de tipos de bandeja e idade de transplantio das mudas de alface (Lactuca sativa L.) tipo americana em ensaio, realizado de março a junho de 2002 no município de Três Pontas, MG. Utilizou-se o delineamento experimental em blocos ao acaso em esquema fatorial 3 x 5, compreendendo três tipos de bandejas (128; 200 e 288 células), cinco idades de transplantio (22; 26; 30; 34 e 38 dias após a semeadura) e 3 repetições. Mudas produzidas em bandejas de poliestireno expandido com 128 células e transplantadas com 38 dias de idade apresentaram maior massa fresca e seca, número de folhas e altura de plantas. A maior produtividade comercial foi obtida com as mudas produzidas em bandejas de 128 células, seguida da bandeja com 200 células, sendo o pior desempenho apresentado pelas mudas produzidas em bandejas com 288 células. A idade de transplantio das mudas variou em função do tipo de bandeja utilizado, podendo as mudas serem transplantadas de 22-38 dias da semeadura quando são utilizadas as bandejas com 128 e 200 células, com preferência para os períodos menores (22-30 dias). Para a bandeja com 288 células, as mudas devem ser transplantadas mais tardiamente, aos 38 dias da semeadura.

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Guan, Steven, Ko-Tsung Hsu und Parag V. Chitnis. „Fourier Neural Operator Network for Fast Photoacoustic Wave Simulations“. Algorithms 16, Nr. 2 (19.02.2023): 124. http://dx.doi.org/10.3390/a16020124.

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Simulation tools for photoacoustic wave propagation have played a key role in advancing photoacoustic imaging by providing quantitative and qualitative insights into parameters affecting image quality. Classical methods for numerically solving the photoacoustic wave equation rely on a fine discretization of space and can become computationally expensive for large computational grids. In this work, we applied Fourier Neural Operator (FNO) networks as a fast data-driven deep learning method for solving the 2D photoacoustic wave equation in a homogeneous medium. Comparisons between the FNO network and pseudo-spectral time domain approach were made for the forward and adjoint simulations. Results demonstrate that the FNO network generated comparable simulations with small errors and was orders of magnitude faster than the pseudo-spectral time domain methods (~26× faster on a 64 × 64 computational grid and ~15× faster on a 128 × 128 computational grid). Moreover, the FNO network was generalizable to the unseen out-of-domain test set with a root-mean-square error of 9.5 × 10−3 in Shepp–Logan, 1.5 × 10−2 in synthetic vasculature, 1.1 × 10−2 in tumor and 1.9 × 10−2 in Mason-M phantoms on a 64 × 64 computational grid and a root mean squared of 6.9 ± 5.5 × 10−3 in the AWA2 dataset on a 128 × 128 computational grid.

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LAUWERS, P. G., und T. WITTLICH. „INVERSION OF THE FERMION MATRIX IN LATTICE QCD BY MEANS OF PARALLEL-TRANSPORTED MULTIGRID (PTMG)“. International Journal of Modern Physics C 04, Nr. 03 (Juni 1993): 609–20. http://dx.doi.org/10.1142/s0129183193000586.

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The standard PTMG method, invented and tested for the inversion of the fermion matrix (Dirac-operator) in the case of U(1) and SU(2) lattice gauge theories with staggered fermions, has now been generalized to SU(3). A crucial ingredient of the new algorithm is the way SU(3) link elements are averaged in the generation of the coarse grid link elements. Numerical results are presented for the two-dimensional case. For 128 × 128 lattices and physically relevant values of the coupling constant β and of the quark mass mq, the new algorithm is an order of magnitude faster in CPU time than its leading competitor, the Conjugate-Gradient algorithm.

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Boland, Rochelle E., Laura Nardo und Stuart B. Hooper. „Cortisol pretreatment enhances the lung growth response to tracheal obstruction in fetal sheep“. American Journal of Physiology-Lung Cellular and Molecular Physiology 273, Nr. 6 (01.12.1997): L1126—L1131. http://dx.doi.org/10.1152/ajplung.1997.273.6.l1126.

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We have investigated whether cortisol pretreatment of sheep fetuses will result in a greater liquid accumulation within the lung and a greater lung growth response to obstruction of the fetal trachea. Chronically catheterized fetal sheep received either 1) a cortisol infusion at an increasing dose (1.5–4.0 mg/day) from days 118 to 127 of gestation; the fetal trachea was then obstructed from days 128 to 131 of gestation ( n = 4); 2) a saline infusion from days 118 to 127 of gestation; the fetal trachea was then obstructed from days 128 to 131 of gestation ( n = 4); or 3) a saline infusion from days 118 to 127 of gestation with no period of tracheal obstruction (control; n = 4). Fetal tracheal pressures were measured from days 128 to 131 of gestation, whereas lung liquid secretion rates and volumes were measured on days 118, 128, and 131 of gestation. On day 131 of gestation, all fetuses were given an intravenous injection of [3H]thymidine and were killed 8 h later. Cortisol pretreatment increased the volume of liquid that accumulated within the fetal lung from 69.5 ± 4.1 to 96.1 ± 14.1 ml/kg after 3 days of tracheal obstruction. Similarly, cortisol pretreatment significantly enhanced the increase in lung DNA content from 257.4 ± 11.0 to 309.1 ± 16.3 mg/kg after 3 days of tracheal obstruction. We conclude that pretreatment of fetuses with cortisol increases the volume of liquid that accumulates after tracheal obstruction and, as a result, increases the fetal lung growth response to tracheal obstruction.

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Zisovska, Elizabeta, und Bratica Lazovska. „The Importance of Down Syndrome Phenocopies in the Newborns in Tertiary Obstetric Hospital“. Open Access Macedonian Journal of Medical Sciences 1, Nr. 1 (15.12.2013): 32–37. http://dx.doi.org/10.3889/oamjms.2013.007.

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Background: A phenotype is the composite of the observable characteristics, and in some cases it is not representative for identification of recognized genetic structure. Aim: The aims of the study were to present the incidence and clinical features of dismorphia in newborn children, and to investigate the prevalence of phenocopies among them. Material and Methods: Newborns born at the University Clinic for Gynecology & Obstetrics, having at least 3 minor anomalies (mm) specific for Down syndrome were investigated. Patients’ histories, observation, cytogenetic analysis of peripheral blood samples were analysed. Results: Among 17835 liveborns during 5 years’ period, 128 were detected having at least 3 mm, calculated incidence of dysmorphia 0.83% (1:139). Cytogenetic analysis was not performed in 3.1% (4/128) due to immediate death or transfers elsewhere, 30.5% (39/128) were confirmed Down syndrome. Cytogenetic analysis showed trisomy 21 in 97.4%; Robertsonian translocation had one newborn (2.6%); normal cytogenetic structure had 66.4% (85/128) of the newborns. Conclusons: Other studies didn’t highlight the proportion of phenocopies of Down syndrome in unselected population of newborns, mainly investigating sick children, disabled, or older-aged. As more the critical role of phenocopy emerges, the more the initial difficulty in detecting gene-gene interactions is amplified. Neglecting the possible presence of phenocopies in complex traits, heavily affects the analysis of their genetic data.

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Shan, Li-Qun, Hong-Wang Yan, Hui Lin, Hong-Xi Yu, Bo Zhang, Ming-Dong Li und Shuai Zhang. „Effects of miR-128 on the Proliferation and Apoptosis of Lung Cancer of Non-Small Cell by Regulating Reversion-Inducing Cysteine-Rich Protein with Kazal Motifs (RECK)“. Journal of Biomaterials and Tissue Engineering 10, Nr. 8 (01.08.2020): 1102–8. http://dx.doi.org/10.1166/jbt.2020.2371.

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The study was aimed to analyse the effects of miR-128 on the proliferation and apoptosis of lung cancer cells of non-small cell by regulating RECK. The expression of miR-128 in non-small cell lung cancer (NSCLC) and its paracancerours tissues was analyzed by sequencing. miR-128 expression level in NSCLC and its paracancerours tissues was detected by qPCR. We over expressed miR-128 by mimics in A549 NSCLC cell line. Establish blank and negative control group. miR-128 and RECK expression level in each group was detected by qPCR. Use MTT assay to test the proliferation ability of each group. The apoptosis level and the level of ROS in each group were tested by hoechst 33258. The expression level of apoptosis-related protein and p38 NF- B signal pathway-related protein in each group was tested by Western blot. The results of sequencing and qPCR showed that compared with the blank control group, the expression level of miR-128 mRNA was significantly higher in the adjacent tissues than in the adjacent tissues (P < 0 05). The expression levels of miR128 mRNA and RECK mRNA in the overexpression group were significantly increased (P <0 05); the cell proliferation ability in the overexpression group was significantly reduced (P < 0 05), and the level of apoptosis was significantly increased (P < 0 05). Overexpression group Caspase-3, Bcl2/Bax, P-p38, NF-B expression levels were significantly increased (P < 0 05). MiR-128 increases ROS level in NSCLC cells, inhibits cell proliferation and promotes cell apoptosis by regulating RECK and acting on p38 NF-κB signaling pathway.

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Werner, Karel. „Vividharatnakarandaka. Festgabe für Adelheid Mette. Edited by Christine Chojnacki, Jens-Uwe Hartmann and Volker M. Tschannerl.“ Buddhist Studies Review 19, Nr. 1 (21.01.2002): 79–83. http://dx.doi.org/10.1558/bsrv.v19i1.14428.

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Vividharatnakarandaka. Festgabe für Adelheid Mette. Edited by Christine Chojnacki, Jens-Uwe Hartmann and Volker M. Tschannerl. (Indica et Tibetica 37) Indica et Tibetica Verlag, Swisttal-Odendorf 2000. 540 pp. DM 128. ISBN 3-923776-37-3.

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Langner, Bernd, und Hans Offenwanger. „Rezension von: Offenwanger, Hans, Grünkraut anno 1900“. Schwäbische Heimat 70, Nr. 4 (21.12.2021): 502–3. http://dx.doi.org/10.53458/sh.v70i4.1297.

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Hans Offenwanger: Grünkraut anno 1900. Hrsg. von der Gemeinde Grünkraut. Biberacher Verlagsdruckerei 2018. 128 Seiten mit ca. 220 teils farbigen Fotos, Karten und Plänen. Kartoniert € 15,–. ISBN 978-3-947348-21-3 (Erhältlich bei der Gemeinde)

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Molinet-Medina, Xabier. „Inteligencia ARTificial y Educación Artística“. Arte, Individuo y Sociedad 35, Nr. 4 (06.10.2023): 1513–14. http://dx.doi.org/10.5209/aris.90282.

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Ton That Huu, Dat, Ha Tran Phuong, Phan Thi Diem Tran, Bakeo Souvannalath, Hieu Le Trung, Duc Viet Ho und Cuong Le Canh Viet. „Secondary Metabolites From the Grasshopper-Derived Entomopathogenic Fungus Aspergillus Tamarii NL3 and Their Biological Activities“. Natural Product Communications 17, Nr. 12 (Dezember 2022): 1934578X2211415. http://dx.doi.org/10.1177/1934578x221141548.

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Chromatographic purification of the ethyl acetate extract of the entomopathogenic fungus Aspergillus tamarii NL3 culture broth led to the isolation of griseofulvin (1), isogriseofulvin (2), cytochalasin J (3), solamargine (4), and solasonine (5). The chemical structures of these compounds were identified by HRESIMS and NMR spectra, as well as by comparison with literature data. This is the first report on the isolation of 1-4 from the Aspergillus genus and compound 5 from A tamarii. Compounds 1 and 2 exhibited antifungal activity against the reference fungi with MICs of 16 to 128 µg/mL. Compound 3 displayed weak antimicrobial activity against most of the tested microorganisms with MICs ≥ 128 µg/mL, except for Bacillus subtilis and Aspergillus niger with MICs of 64 µg/mL. Compounds 4 and 5 showed activity against a wide spectrum of the reference microorganisms with MICs of 16 to 128 µg/mL but showed stronger antifungal than antibacterial activity. Furthermore, all isolates exhibited weak ABTS and DPPH scavenging activities with scavenging rates of 18.92% to 32.64% and 24.62% to 31.06%, respectively, at the concentration of 100 µg/mL.

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Williams, Meghan Todt. „Entrepreneurial Music Education: Professional Learning in Schools and the Industry, Kristina Kelman (2020)“. Journal of Popular Music Education 4, Nr. 3 (01.11.2020): 389–92. http://dx.doi.org/10.1386/jpme_00037_5.

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Review of: Entrepreneurial Music Education: Professional Learning in Schools and the Industry, Kristina Kelman (2020) Cham: Palgrave Macmillan, 251 pp., ISBN 978-3-03037-128-9, h/bk, €83.19 ISBN 978-3-03037-129-6, ebook, €67.40

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Vélez Upegui, Mauricio. „De de sobremesa“. Íkala, Revista de Lenguaje y Cultura 3, Nr. 1 (22.03.1998): 95–128. http://dx.doi.org/10.17533/udea.ikala.8067.

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43

Grünenwald, Elisabeth, und Werner Dettelbacher. „Rezension von: Dettelbacher, Werner, Zwischen Neckar und Donau“. Württembergisch Franken 61 (03.04.2024): 169. http://dx.doi.org/10.53458/wfr.v61i.11121.

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Lu, Weiqun, Jia Wang, Guohua Yang, Nanrong Yu, Zhiliang Huang, Houwei Xu, Jianchang Li et al. „Correction: Posttranscriptional regulation of Galectin-3 by miR-128 contributes to colorectal cancer progression“. Oncotarget 9, Nr. 15 (23.02.2018): 12535. http://dx.doi.org/10.18632/oncotarget.24558.

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Bihan, H., G. Nguyen, R. Cohan, C. Menu, K. Soufi, G. Reach und H. LeClésiau. „P2-128 - Association score de précarité épices, mesure en 3 dimensions et paramètres métaboliques“. Annales d'Endocrinologie 67, Nr. 5 (Oktober 2006): 519. http://dx.doi.org/10.1016/s0003-4266(06)72959-6.

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Fila, L., J. Brazova und J. Musil. „128 Supplementation with n-3 PUFA in CF patients: analysis of exhaled breath condensate“. Journal of Cystic Fibrosis 6 (Juni 2007): S32. http://dx.doi.org/10.1016/s1569-1993(07)60117-9.

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T. Hashim, Ashwaq. „Type-3 Feistel Network of The 128-bits Block Size Improved Blowfish Cryptographic Encryption“. Engineering and Technology Journal 27, Nr. 2 (01.01.2009): 235–46. http://dx.doi.org/10.30684/etj.27.2.2.

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Gerber, Helmut, und Rainer Redies. „Rezension von: Redies, Rainer, 200 Jahre Cannstatter Wasen“. Zeitschrift für Württembergische Landesgeschichte 78 (25.01.2022): 617. http://dx.doi.org/10.53458/zwlg.v78i.1581.

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Wrobbel, Sibylle, und Wolfgang Walker. „Rezension von: Walker, Wolfgang (Hrsg.), Schwäbischer Heimatkalender 2018“. Schwäbische Heimat 68, Nr. 4 (13.01.2022): 514–15. http://dx.doi.org/10.53458/sh.v68i4.1458.

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Friker, Lea L., Thomas Perwein, Andreas Waha, Evelyn Dörner, Rebecca Klein, Mirjam Blattner-Johnson, Julian P. Layer et al. „HGG-26. MLH1, MSH2, MSH6, AND PMS2 IMMUNOHISTOCHEMISTRY REPRESENTS A HIGHLY SENSITIVE SCREENING METHOD FOR MISMATCH REPAIR DEFICIENCY SYNDROMES IN PEDIATRIC HIGH-GRADE GLIOMA“. Neuro-Oncology 26, Supplement_4 (18.06.2024): 0. http://dx.doi.org/10.1093/neuonc/noae064.310.

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Abstract BACKGROUND Pediatric central nervous system (CNS) tumors can occur as first manifestations of cancer predisposition syndromes (CPS) resulting from pathogenic variants in DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, and PMS2. Early detection of MMR deficiencies (MMRD) may warrant the therapeutic use of checkpoint inhibitors and enable genetic consulting for the patient’s families. METHODS We prospectively screened 128 pediatric high-grade gliomas (pedHGG) for MMR protein expression by immunohistochemistry (IHC) as part of the HIT-HGG-2013 clinical trial. We compared IHC results to independently collected patient information on CPS including MMRD to test the method’s efficiency in screening for Lynch syndrome and Constitutional MMRD syndrome CMMRD. RESULTS From 128 successfully tested tumors, ten cases (10/128, 7.8%), showed loss of expression of at least one of the MMR proteins. In seven of the ten affected patients (7/128, 5.5%), genetic testing uncovered heterozygous (6/10) or homozygous (1/10) pathogenic germline variants in MMR genes (MLH1, MSH2 or MSH6) confirming the diagnosis of Lynch syndrome respectively CMMRD. In three cases (3/128 2.3%), MMR alterations were restricted to tumor tissue. The group of diffuse midline gliomas, H3 K27-altered, (67/128, 52.3%) did not show MMR alterations, while either somatic or germline MMR mutations were detected in two of eight patients with diffuse hemispheric glioma, H3 G34-mutant. In 88 patients (88/128, 68.8%) either clinical or molecular-genetic information on CPS could be provided. All ten patients with signs of MMRD were successfully detected by IHC from tumor tissue. CONCLUSIONS IHC for MMR proteins represents a highly sensitive screening method for MMRD in pedHGG. Considering the occurrence of at least 11.5% (7/61) of MMRD in pediatric patients with diffuse high-grade glioma excluding DMG, MMRD IHC should be part of routine diagnostics as cost-effective, broadly available and robust screening method.

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